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TDMS Study 05100-03 Pathology Tables

NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97
Route: DOSED FEED                                                                                                 Time: 12:16:39




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1330-78-5

       Lock Date:  12/30/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 0| 4| 4| 2| 0| 2| 4| 0| 4| 2| 4| 4| 2| 0| 2| 0| 2| 2| 0| 2| 4|             
                             DAY ON TEST   | 7| 9| 7| 7| 9| 5| 5| 7| 9| 7| 5| 9| 5| 7| 1| 5| 7| 9| 7| 9| 7| 7| 9| 7| 5|             
                                           | 4| 2| 4| 4| 2| 6| 6| 4| 7| 8| 7| 7| 6| 4| 2| 7| 4| 2| 4| 3| 4| 8| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                             X            |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Inflammation, Granulomatous          |                                                 1                        |             
      Mixed Cell Focus                     |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Fat, Necrosis                        |                                        2                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                      1                                      1            |             
      Acinus, Atrophy                      |                1  1                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Degeneration                         |                                                                          |             
      Myocardium, Degeneration             |                   1                 1     2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                        1                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 0| 4| 4| 2| 0| 2| 4| 0| 4| 2| 4| 4| 2| 0| 2| 0| 2| 2| 0| 2| 4|             
                             DAY ON TEST   | 7| 9| 7| 7| 9| 5| 5| 7| 9| 7| 5| 9| 5| 7| 1| 5| 7| 9| 7| 9| 7| 7| 9| 7| 5|             
                                           | 4| 2| 4| 4| 2| 6| 6| 4| 7| 8| 7| 7| 6| 4| 2| 7| 4| 2| 4| 3| 4| 8| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      C-Cell, Hyperplasia                  |                2  2                 2     2                             2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Cyst                                 |                   X                                                  X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Dilatation                           |    2                                                                     |             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 0| 4| 4| 2| 0| 2| 4| 0| 4| 2| 4| 4| 2| 0| 2| 0| 2| 2| 0| 2| 4|             
                             DAY ON TEST   | 7| 9| 7| 7| 9| 5| 5| 7| 9| 7| 5| 9| 5| 7| 1| 5| 7| 9| 7| 9| 7| 7| 9| 7| 5|             
                                           | 4| 2| 4| 4| 2| 6| 6| 4| 7| 8| 7| 7| 6| 4| 2| 7| 4| 2| 4| 3| 4| 8| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1        1     1  1                       1                 1        1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +              +  +  +     +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 2| 4| 2| 4| 0| 4| 4| 4| 2| 4| 0| 0| 0| 0| 2| 4| 0| 0| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 5| 7| 5| 7| 5| 9| 5| 5| 5| 7| 5| 9| 9| 9| 9| 7| 5| 9| 9| 3| 3| 2| 3| 3|             
                                           | 2| 6| 8| 7| 4| 7| 2| 6| 6| 6| 8| 6| 3| 3| 7| 3| 8| 7| 7| 7| 1| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Basophilic Focus                     |                      X                                                  X|             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                   X     X|             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Inflammation, Chronic                |             1                                                            |             
      Acinus, Atrophy                      |                      1     1                                1        1  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Inflammation, Chronic                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Degeneration                         |             1                                                            |             
      Myocardium, Degeneration             |    1                                                        2  1        1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Hyperplasia                          |                      1                                         2         |             
      Vacuolization Cytoplasmic            |                                                             1           1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 2| 4| 2| 4| 0| 4| 4| 4| 2| 4| 0| 0| 0| 0| 2| 4| 0| 0| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 5| 7| 5| 7| 5| 9| 5| 5| 5| 7| 5| 9| 9| 9| 9| 7| 5| 9| 9| 3| 3| 2| 3| 3|             
                                           | 2| 6| 8| 7| 4| 7| 2| 6| 6| 6| 8| 6| 3| 3| 7| 3| 8| 7| 7| 7| 1| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +        +     +  +  +  +     +  +  +     +              +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2                 2     2     2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                      1                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Prolapse                             |                                                                X         |             
      Endometrium, Hyperplasia             |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        M     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +     +  +  +  +     +  +  M     +              +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 2| 4| 2| 4| 0| 4| 4| 4| 2| 4| 0| 0| 0| 0| 2| 4| 0| 0| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 5| 7| 5| 7| 5| 9| 5| 5| 5| 7| 5| 9| 9| 9| 9| 7| 5| 9| 9| 3| 3| 2| 3| 3|             
                                           | 2| 6| 8| 7| 4| 7| 2| 6| 6| 6| 8| 6| 3| 3| 7| 3| 8| 7| 7| 7| 1| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|             
    0 PPM                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X     X                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Inflammation, Chronic Active         |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          |             1                                               2  1  2  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +     +  +  +  +     +  +  +     +              +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 7| 3| 3| 3| 3| 9|             
                                           | 2| 2| 7| 3| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 PPM                                  | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                 X  X     X                    X  X           X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                      X                                                   |             
      Degeneration, Cystic                 |    1                                                                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                    X           X     X                              |             
      Inflammation, Granulomatous          |                                        3                                 |             
      Mixed Cell Focus                     |          X        X                                            X         |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +           +                        |             
      Fat, Necrosis                        |                                     2           2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                            1     2           1     1     3        1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Myocardium, Degeneration             | 2  1  2  1  1  2           3     1  2  2  1  1  1     1  1     1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2     2              2     1     1     2     1  1        1|             
      Vacuolization Cytoplasmic            | 1     1     1  1                 1  1                    1              1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 7| 3| 3| 3| 3| 9|             
                                           | 2| 2| 7| 3| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 PPM                                  | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                1                                            1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     1           2  2        3  2        3  2  2  4     3  2  3  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                   4                                                      |             
      Hyperplasia                          |                      2                                            2      |             
      Inflammation, Chronic                |                                     2     2                    1         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                      3   |             
      Prolapse                             |                                                 X                        |             
      Endometrium, Hyperplasia             |                                        2              1                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                      +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                       +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Granulomatous          |                         2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 7| 3| 3| 3| 3| 9|             
                                           | 2| 2| 7| 3| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 PPM                                  | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |       X  X  X     X           X              X        X                 X|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      1           2                                1     1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Lens, Cataract                       |    4                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                          2               |             
      Nephropathy                          |    1  2     1  1  1     1     2  3  3     1  1     1  1  1  1  1  1  1  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 6| 1| 7| 7| 5| 7| 5| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 7| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3|              |            |
                                           | 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 8| 4| 2| 2| 7| 2| 2| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Ulcer                                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Basophilic Focus                     |    X           X     X  X  X  X     X  X     X        X  X               |     21     |
      Clear Cell Focus                     |                      X                                                   |      1     |
      Cyst                                 |                                                                          |      2     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                 X                        |      3     |
      Hepatodiaphragmatic Nodule           |                                              X                           |      7     |
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
      Mixed Cell Focus                     |             X                                            X               |      5     |
      Serosa, Inflammation, Chronic        |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +                                 |   4        |
      Fat, Necrosis                        |                                        2                                 |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Acinus, Atrophy                      |          1  1        1                 1                                 |     17  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Degeneration                         |                                                                          |      1  1.0|
      Myocardium, Degeneration             | 1  1     1  2  1  1  2  1     2        2  2  1     2  1                  |     37  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 6| 1| 7| 7| 5| 7| 5| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 7| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3|              |            |
                                           | 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 8| 4| 2| 2| 7| 2| 2| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |       1        1  3     1                          2  1  1               |     18  1.4|
      Vacuolization Cytoplasmic            |                   1                 1     1              1               |     15  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |                2        1                    2                           |      6  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  75        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |                         X                                                |      1     |
      Pars Distalis, Hyperplasia           |                2                                         2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      C-Cell, Hyperplasia                  | 3  3  3  1  3     2  3  3  3  2     2  2  2              2               |     37  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Abscess                              |                                                                          |      1  4.0|
      Hyperplasia                          |                                     2  2              2                  |      5  2.0|
      Inflammation, Chronic                |    2                    2                                                |      5  1.8|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Dilatation                           |                                                                          |      2  2.5|
      Prolapse                             |                                                                          |      2     |
      Endometrium, Hyperplasia             |    2              2     2                          1                     |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Fibrosis                             |                                        1                                 |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 6| 1| 7| 7| 5| 7| 5| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 7| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3|              |            |
                                           | 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 8| 4| 2| 2| 7| 2| 2| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  77        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +               |  77        |
      Hyperplasia, Cystic                  |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Osteopetrosis                        |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hypothalamus, Compression            |       X                    X  X     X                                    |     13     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
      Cyst                                 |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                    2                     |      5  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          | 2  1  4  1  1     1  1        2     1  1  1  1     3     1               |     46  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|             
                             DAY ON TEST   | 7| 7| 7| 5| 5| 7| 9| 7| 7| 9| 9| 5| 9| 7| 9| 5| 9| 5| 0| 9| 7| 9| 5| 9| 7|             
                                           | 4| 4| 8| 7| 6| 4| 3| 8| 4| 3| 2| 7| 7| 8| 2| 7| 2| 6| 4| 3| 4| 3| 6| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    75 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Inflammation, Necrotizing            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Peyer's Patch, Mineralization        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                       X  X  X            |             
      Inflammation, Granulomatous          |    1                    1                             1                 1|             
      Mixed Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Mucosa, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Myocardium, Degeneration             |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                    1                     |             
      Vacuolization Cytoplasmic            |                                                       1                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|             
                             DAY ON TEST   | 7| 7| 7| 5| 5| 7| 9| 7| 7| 9| 9| 5| 9| 7| 9| 5| 9| 5| 0| 9| 7| 9| 5| 9| 7|             
                                           | 4| 4| 8| 7| 6| 4| 3| 8| 4| 3| 2| 7| 7| 8| 2| 7| 2| 6| 4| 3| 4| 3| 6| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    75 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +        +  +  +     M  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      C-Cell, Hyperplasia                  |             2                                      2              2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                   1                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        M  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 2| 0| 2| 2| 0| 0| 4| 0| 2| 0| 4| 0| 4| 2| 0| 2| 0| 4| 0| 2|             
                             DAY ON TEST   | 7| 7| 7| 5| 5| 7| 9| 7| 7| 9| 9| 5| 9| 7| 9| 5| 9| 5| 0| 9| 7| 9| 5| 9| 7|             
                                           | 4| 4| 8| 7| 6| 4| 3| 8| 4| 3| 2| 7| 7| 8| 2| 7| 2| 6| 4| 3| 4| 3| 6| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    75 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axon, Degeneration                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +  +                                          |             
      Inflammation, Chronic Active         |                            1  1                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
      Nephropathy                          |             1  1                                                  1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +  +  +     +  +  +           +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 2| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 9| 5| 5| 5| 9| 5| 5| 7| 9| 5| 9| 2| 7| 7| 7| 5| 9| 7| 3| 3| 3| 3| 3|             
                                           | 7| 5| 7| 6| 7| 6| 7| 6| 6| 4| 3| 6| 2| 2| 8| 4| 4| 7| 2| 4| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
    75 PPM                                 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Peyer's Patch, Mineralization        |                                     1                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X           X                          X  X         |             
      Eosinophilic Focus                   |                                                                         X|             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                       X                  |             
      Inflammation, Granulomatous          |                                              1                           |             
      Mixed Cell Focus                     |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                1                                                     1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Mucosa, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Myocardium, Degeneration             |                2        1                                   3           1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 2| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 9| 5| 5| 5| 9| 5| 5| 7| 9| 5| 9| 2| 7| 7| 7| 5| 9| 7| 3| 3| 3| 3| 3|             
                                           | 7| 5| 7| 6| 7| 6| 7| 6| 6| 4| 3| 6| 2| 2| 8| 4| 4| 7| 2| 4| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
    75 PPM                                 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2     1     2           2                          2  2  3  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                1     1                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                         X                       X           X     X      |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                                                   X      |             
      Endometrium, Hyperplasia             |                                                             2     1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 0| 4| 4| 4| 0| 4| 4| 2| 0| 4| 0| 2| 2| 2| 2| 4| 0| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 9| 5| 5| 5| 9| 5| 5| 7| 9| 5| 9| 2| 7| 7| 7| 5| 9| 7| 3| 3| 3| 3| 3|             
                                           | 7| 5| 7| 6| 7| 6| 7| 6| 6| 4| 3| 6| 2| 2| 8| 4| 4| 7| 2| 4| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|             
    75 PPM                                 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axon, Degeneration                   |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                      1   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Hemorrhage                           |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Lens, Cataract                       |                                                                         3|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Nephropathy                          |    1                 1     1     1                             1  1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 3| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 9| 2| 3| 3|             
                                           | 7| 1| 1| 1| 1| 1| 9| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 3| 7| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    75 PPM                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                   3      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Mineralization        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X  X  X     X        X     X  X                    X            |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                           X  X           X  X     X      |             
      Inflammation, Granulomatous          |                                              2                           |             
      Mixed Cell Focus                     |                X                                   X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +                       +  +                 +         |             
      Fat, Necrosis                        |                   2                       3  3                 3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1           1                 1           1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Mineralization               |             2                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                         2                                                |             
      Myocardium, Degeneration             | 1        2  2  1  3  1  2     2     2  1  1  1  1  1     1        2  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2     2                             3  2        2  1           2  2   |             
      Vacuolization Cytoplasmic            |       1                 1                                1     3     1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                      3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 3| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 9| 2| 3| 3|             
                                           | 7| 1| 1| 1| 1| 1| 9| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 3| 7| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    75 PPM                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X        X        X   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                 2                       2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3  2     2  3  1              3  2        2  2     4  2  1  2  2  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                3        3                    2                          2|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia             |       2                                      1                       1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                         +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2                                                                     |             
      Inflammation, Granulomatous          |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 3| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 9| 2| 3| 3|             
                                           | 7| 1| 1| 1| 1| 1| 9| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 3| 7| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    75 PPM                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |    X                                                                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axon, Degeneration                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1     1                 2              1                       1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                        +     +   |             
      Hemorrhage                           |       3                                                                  |             
      Cornea, Inflammation, Chronic        |                                                                2         |             
      Lens, Cataract                       |                                                                      3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +                                                              +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    1        1  1  1        1  1  1     1  1        1  1        1        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 5| 0| 3| 3| 1| 3|              |            |
                                           | 1| 1| 0| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 1| 8| 1| 1| 1| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    75 PPM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Peyer's Patch, Mineralization        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Basophilic Focus                     | X              X        X     X     X  X              X  X               |     21     |
      Eosinophilic Focus                   |                X                    X                                    |      3     |
      Fatty Change                         |       2                                      3                           |      2  2.5|
      Hepatodiaphragmatic Nodule           |       X                          X                                       |     11     |
      Inflammation, Granulomatous          |                                                                          |      6  1.2|
      Mixed Cell Focus                     |                                     X                                    |      4     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +        +                           |   7        |
      Fat, Necrosis                        |                                     3                                    |      5  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Acinus, Atrophy                      | 1  1                 1  1                       1  1                     |     12  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Epithelium, Hyperplasia              |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Mucosa, Mineralization               |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
      Mucosa, Epithelium, Hyperplasia      |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
      Myocardium, Degeneration             | 1  1     2  3  2        2     1  1  1  1  1     1     1                  |     36  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 5| 0| 3| 3| 1| 3|              |            |
                                           | 1| 1| 0| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 1| 8| 1| 1| 1| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    75 PPM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          | 1                    2     2                          1                  |     14  1.8|
      Vacuolization Cytoplasmic            |    1     1  1                             1  1                           |     13  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Infarct                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  M               |  76        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Cyst                                 |             X                                                            |      5     |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           | 2        1              1                                3               |      6  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      C-Cell, Hyperplasia                  | 2  2  1     2  4  2  2  2  2  2     2  2  1     2     3  3               |     44  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Hyperplasia                          |             2                                         2                  |      2  2.0|
      Inflammation, Chronic                |                                                                          |      5  2.2|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Cyst                                 |                                        X              X                  |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Cervix, Cyst                         |                                        X                                 |      2     |
      Endometrium, Hyperplasia             |    1                                                                     |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Fibrosis                             |                                                    2                     |      2  2.0|
      Inflammation, Granulomatous          | 2                    1                                                   |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +               |  74        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 5| 0| 3| 3| 1| 3|              |            |
                                           | 1| 1| 0| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 1| 8| 1| 1| 1| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    75 PPM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Hyperplasia, Cystic                  |                               3           3        3                     |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Hypothalamus, Compression            |       X        X                    X     X                              |      5     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  93        |
      Axon, Degeneration                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Inflammation, Chronic                |                                                                          |      6  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   5        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
      Lens, Cataract                       |          3                                                               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
      Nephropathy                          | 1  2  2  1  1  1  1  1  1  1  1  1  1  1     1  1     1                  |     41  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  81        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|             
                             DAY ON TEST   | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|             
                                           | 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150 PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Parasite Metazoan                    |                                  X        X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Basophilic Focus                     |          X                                   X                           |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          | 1                                                                        |             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Acinus, Atrophy                      |                                              1                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Ulcer                                |                                                                          |             
      Mucosa, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Degeneration                         |                                                                          |             
      Myocardium, Degeneration             |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Vacuolization Cytoplasmic            |                                  1                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|             
                             DAY ON TEST   | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|             
                                           | 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150 PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +     +  +     +  +  M  +  M  M     +     +     +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Cyst                                 |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           |                               2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      C-Cell, Hyperplasia                  |          2  2        3                             2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Inflammation, Chronic                |                                  1  1                                    |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Cyst                                 |                                                                          |             
      Interstitium, Hyperplasia            |             1           1        1     1           1     1               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
      Wall, Hyperplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Anisocytosis                         |                                                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Congestion                           |                                                                          |             
      Erythrophagocytosis                  |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +  +     +  +     +  M  +  +  +  +     +     +     +         |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|             
                             DAY ON TEST   | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|             
                                           | 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150 PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Mediastinum, Necrosis           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Nephropathy                          | 1        1  1        2                    1        1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 9| 5| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 2| 2| 2| 7| 2|             
                                           | 6| 2| 6| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 9| 9| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|             
    150 PPM                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                                            X     X     X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                         X|             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X                 X                                       |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                X        X|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                1                                               1  1  1  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                      4   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                    1                     |             
      Myocardium, Degeneration             |                1                                            1  1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2              1     2   |             
      Mineralization                       |                                                       2                  |             
      Vacuolization Cytoplasmic            |                                              1     1  1                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 9| 5| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 2| 2| 2| 7| 2|             
                                           | 6| 2| 6| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 9| 9| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|             
    150 PPM                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pigmentation, Hemosiderin            |                            2                                             |             
      Pars Distalis, Cyst                  |                            X                                             |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2  2           2                                3  3  2  3  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |             2                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Interstitium, Hyperplasia            | 1        1           1                             1                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
      Wall, Hyperplasia                    |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Anisocytosis                         |                                                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +     +  +  +           +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Erythrophagocytosis                  |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 9| 5| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 2| 2| 2| 7| 2|             
                                           | 6| 2| 6| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 9| 9| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|             
    150 PPM                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                      2   |             
      Fat, Mediastinum, Necrosis           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1                          1     1              1           1  1  2  3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 7| 3| 3| 3| 6| 0| 1| 1| 3| 3| 0| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 9| 0| 2| 2| 0| 0| 0| 0| 6| 5| 9| 1| 0| 0| 5| 5| 0| 0| 7| 0| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    150 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X        X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X     X     X              X     X                 X     X  X   |             
      Clear Cell Focus                     |                                                                X         |             
      Degeneration, Cystic                 |                                                             1            |             
      Eosinophilic Focus                   |                                     X  X                                 |             
      Fatty Change                         |                                  3                                       |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |          X                                   X                           |             
      Pigmentation, Hemosiderin            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Fat, Necrosis                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                            1  2     1  1  3        1  1           1     1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         3                                                |             
      Mucosa, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Myocardium, Degeneration             | 1  2  1  1     1     3  2  2        1  2        2  2  1  2  1     2  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                          1        2        1        2  2           1   |             
      Mineralization                       |                                                                          |             
      Vacuolization Cytoplasmic            |                   1     1        1  1  1        1  1        1  1  1     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 7| 3| 3| 3| 6| 0| 1| 1| 3| 3| 0| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 9| 0| 2| 2| 0| 0| 0| 0| 6| 5| 9| 1| 0| 0| 5| 5| 0| 0| 7| 0| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    150 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X           X                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                               3  2     2     3           1           2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  3     2  2  2  3  2     3  1  2  2  2  2  3  3  2  1     3  2  2  3  4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                      2   |             
      Wall, Hyperplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
      Anisocytosis                         |                                  X                                       |             
      Polychromasia                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Erythrophagocytosis                  |                                  3                                       |             
      Pigmentation, Hemosiderin            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 7| 3| 3| 3| 6| 0| 1| 1| 3| 3| 0| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 9| 0| 2| 2| 0| 0| 0| 0| 6| 5| 9| 1| 0| 0| 5| 5| 0| 0| 7| 0| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    150 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              | 3                                                                        |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                             X  X        X|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2                                                         |             
      Fat, Mediastinum, Necrosis           |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1        1              1        1  1  1  1  1  2     1     1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 6| 5| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 0| 3| 3| 2| 7| 3| 9| 9| 3| 3| 3| 3| 0| 3|              |            |
                                           | 0| 2| 4| 0| 0| 0| 5| 0| 0| 4| 2| 0| 7| 2| 0| 0| 0| 0| 4| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    150 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Parasite Metazoan                    |                                     X                                    |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  78        |
      Parasite Metazoan                    |                                              X                           |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Basophilic Focus                     | X     X     X  X     X           X        X  X           X               |     25     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      3     |
      Fatty Change                         |                         2                                                |      2  2.5|
      Hepatodiaphragmatic Nodule           |                                  X           X                           |      4     |
      Inflammation, Granulomatous          |                   2                                                      |      2  1.5|
      Mixed Cell Focus                     |       X                                                                  |      5     |
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                +           +                  |   4        |
      Fat, Necrosis                        |          2                                2           2                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Acinus, Atrophy                      |    1              2        1     1  1  1              3                  |     22  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Ulcer                                |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                               2     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                                     2                                    |      2  2.5|
      Mucosa, Mineralization               |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Degeneration                         |                                                                          |      1  1.0|
      Myocardium, Degeneration             |    1     1  1     2  1  1        2  1  2  2  3  2        2               |     37  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |    1  2  3        1                 3           2  2  2                  |     18  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 6| 5| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 0| 3| 3| 2| 7| 3| 9| 9| 3| 3| 3| 3| 0| 3|              |            |
                                           | 0| 2| 4| 0| 0| 0| 5| 0| 0| 4| 2| 0| 7| 2| 0| 0| 0| 0| 4| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    150 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                         1  1  1     1  1                                 |     20  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  75        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |          X                          X                    X               |      5     |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      C-Cell, Hyperplasia                  | 3  3     2  3  3  3  2  3  1  2  1  2  1  3  3  1  3     2               |     52  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Inflammation, Chronic                |                                              2  2                        |      5  1.6|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |                                                 X                        |      1     |
      Interstitium, Hyperplasia            |                                                                          |     10  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Dilatation                           |                                        2                                 |      1  2.0|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
      Wall, Hyperplasia                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Anisocytosis                         |                                                                          |      1     |
      Polychromasia                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 6| 5| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 0| 3| 3| 2| 7| 3| 9| 9| 3| 3| 3| 3| 0| 3|              |            |
                                           | 0| 2| 4| 0| 0| 0| 5| 0| 0| 4| 2| 0| 7| 2| 0| 0| 0| 0| 4| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    150 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Congestion                           |                                                                          |      1  3.0|
      Erythrophagocytosis                  |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  77        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                  2                       2               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Osteopetrosis                        |                                                    3                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hypothalamus, Compression            |       X                                                                  |      6     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
      Cyst                                 |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Fat, Mediastinum, Necrosis           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Nephropathy                          | 2     2        1  1  2           1  1           1  2  1                  |     39  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 4| 2| 4| 0| 0| 2| 0| 2| 4| 0| 2| 0| 0| 4| 2| 2| 0| 0| 2| 0| 0| 4| 2|             
                             DAY ON TEST   | 7| 7| 5| 7| 5| 9| 9| 7| 9| 7| 5| 9| 7| 9| 9| 5| 7| 7| 0| 9| 7| 9| 9| 5| 7|             
                                           | 4| 4| 6| 4| 6| 3| 2| 4| 3| 4| 6| 7| 4| 3| 2| 6| 8| 4| 2| 2| 8| 7| 3| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Basophilic Focus                     |                      X                                                   |             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Inflammation, Chronic                |                                                    1                     |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Degeneration                         |                      1                             1                     |             
      Myocardium, Degeneration             |                         1     1              1                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Hyperplasia                          |                               1                                          |             
      Vacuolization Cytoplasmic            | 1  1  1  1  1  2  1  1  2  1  1     1  2  2  1     1     2        2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 4| 2| 4| 0| 0| 2| 0| 2| 4| 0| 2| 0| 0| 4| 2| 2| 0| 0| 2| 0| 0| 4| 2|             
                             DAY ON TEST   | 7| 7| 5| 7| 5| 9| 9| 7| 9| 7| 5| 9| 7| 9| 9| 5| 7| 7| 0| 9| 7| 9| 9| 5| 7|             
                                           | 4| 4| 6| 4| 6| 3| 2| 4| 3| 4| 6| 7| 4| 3| 2| 6| 8| 4| 2| 2| 8| 7| 3| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Pars Distalis, Cyst                  |                               X                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      C-Cell, Hyperplasia                  |             2                 2              3                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |             1                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Cyst                                 |                                     X                                    |             
      Follicle, Cyst                       |             X                                                            |             
      Interstitium, Hyperplasia            | 1  2  1  1  1  1  2  1  1  1  1     1  1  1  1     1     1        2      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Dilatation                           |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
      Wall, Hyperplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Depletion Lymphoid                   |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Abscess                              |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 4| 2| 4| 0| 0| 2| 0| 2| 4| 0| 2| 0| 0| 4| 2| 2| 0| 0| 2| 0| 0| 4| 2|             
                             DAY ON TEST   | 7| 7| 5| 7| 5| 9| 9| 7| 9| 7| 5| 9| 7| 9| 9| 5| 7| 7| 0| 9| 7| 9| 9| 5| 7|             
                                           | 4| 4| 6| 4| 6| 3| 2| 4| 3| 4| 6| 7| 4| 3| 2| 6| 8| 4| 2| 2| 8| 7| 3| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Gliosis                              |                                                                          |             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1  1  1  1  1                 1     1              1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 0| 0| 2| 4| 2| 4| 0| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 7| 7| 5| 9| 5| 5| 5| 5| 7| 5| 9| 5| 9| 9| 7| 5| 7| 5| 9| 5| 6| 7| 5| 0| 2|             
                                           | 8| 8| 7| 7| 6| 6| 6| 7| 4| 6| 3| 7| 7| 2| 4| 6| 4| 6| 2| 7| 7| 0| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|             
    300 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |             X                                                  X        X|             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                                                                         X|             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                         X|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                         1                 1                              |             
      Mixed Cell Focus                     |                                                    X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                             2        1  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Degeneration                         |                                                 1                        |             
      Myocardium, Degeneration             |                1           1                                      1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                2     2   |             
      Vacuolization Cytoplasmic            |             1  1  1     1  1  2        2  1  2  1  1  2     1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 0| 0| 2| 4| 2| 4| 0| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 7| 7| 5| 9| 5| 5| 5| 5| 7| 5| 9| 5| 9| 9| 7| 5| 7| 5| 9| 5| 6| 7| 5| 0| 2|             
                                           | 8| 8| 7| 7| 6| 6| 6| 7| 4| 6| 3| 7| 7| 2| 4| 6| 4| 6| 2| 7| 7| 0| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|             
    300 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +  +     +  +  +        +  +  +  +  +  M     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2  2  2        2                       1        2     3  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                1           2                       1                     |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Cyst                                 |                               X                                X         |             
      Follicle, Cyst                       |                                                                          |             
      Interstitium, Hyperplasia            |             1  1  1     1  1  2        2  1  1  1     3           1     1|             
                                            __________________________________________________________________________|             
   Uterus                                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Dilatation                           |                            1           2     2                           |             
      Cervix, Cyst                         |                            X                                             |             
      Endometrium, Hyperplasia             |                                                                          |             
      Wall, Hyperplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +  +  M     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 0| 0| 2| 4| 2| 4| 0| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 7| 7| 5| 9| 5| 5| 5| 5| 7| 5| 9| 5| 9| 9| 7| 5| 7| 5| 9| 5| 6| 7| 5| 0| 2|             
                                           | 8| 8| 7| 7| 6| 6| 6| 7| 4| 6| 3| 7| 7| 2| 4| 6| 4| 6| 2| 7| 7| 0| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|             
    300 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Hypothalamus, Compression            |                                                                         X|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          |             1  1           1              1                 1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 9| 8| 0| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 9| 2|             
                                           | 0| 8| 9| 7| 3| 9| 9| 9| 7| 4| 9| 9| 9| 9| 9| 9| 2| 5| 9| 9| 9| 4| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                    X     X     X     X  X  X              X     X  X  X|             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                            X     X     X                                 |             
      Fatty Change                         |                            2                                             |             
      Hepatodiaphragmatic Nodule           | X                    X              X              X        X            |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                                                                         2|             
      Mixed Cell Focus                     |                      X                                   X               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                            1        1                                2  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                             3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Myocardium, Degeneration             |    1  2  1  1  3     1     2     2  2  1           2     1           1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3           3  1  1           2     3        1        1  1  3            |             
      Vacuolization Cytoplasmic            | 1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1     1     1     1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 9| 8| 0| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 9| 2|             
                                           | 0| 8| 9| 7| 3| 9| 9| 9| 7| 4| 9| 9| 9| 9| 9| 9| 2| 5| 9| 9| 9| 4| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X           X                           |             
      Inflammation, Chronic                |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             2           2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1           2     4  2  2  3  2  2     3  3     2  2  1        2  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                3                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Follicle, Cyst                       |                                                                          |             
      Interstitium, Hyperplasia            | 1              1  2                    1  1        1        1     1      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                          2               |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
      Wall, Hyperplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                2         |             
      Inflammation, Granulomatous          |                                                                         2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Cystic                  | 4                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 9| 8| 0| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 9| 2|             
                                           | 0| 8| 9| 7| 3| 9| 9| 9| 7| 4| 9| 9| 9| 9| 9| 9| 2| 5| 9| 9| 9| 4| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                              2                           |             
      Hypothalamus, Compression            | X  X        X  X           X  X                       X                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    3                     |             
      Inflammation, Necrotizing            |    2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Synechia                             |                                              3                           |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 3           1  2  2  1        1     1  2                    1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|              |            |
                                           | 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Fibrosis                             |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  77        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Basophilic Focus                     | X           X  X           X  X  X     X     X                           |     23     |
      Degeneration, Cystic                 |          1                                                               |      1  1.0|
      Degeneration, Fatty                  |             1                                                            |      1  1.0|
      Eosinophilic Focus                   |             X  X              X                                          |      7     |
      Fatty Change                         |                   2                                                      |      2  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      7     |
      Hyperplasia                          |    3                                                                     |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      3  1.3|
      Mixed Cell Focus                     |             X                                                            |      4     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   4        |
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Fat, Necrosis                        |       2                                                                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Atrophy                      | 1                 2        1              1  1     2  2                  |     14  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst Epithelial Inclusion            |                                                 X                        |      1     |
      Ulcer                                |                   2                                                      |      1  2.0|
      Epithelium, Hyperplasia              |                      2     2                             3               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Degeneration                         |                                                                          |      3  1.0|
      Myocardium, Degeneration             |       1     1  2  1  2  1  2     1     2     1     2  1                  |     33  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|              |            |
                                           | 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |       2           2        2  1     3  2     2     2  2                  |     22  1.9|
      Vacuolization Cytoplasmic            | 1  1  1           1     1              1  1        1  1  1               |     66  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |                   2        2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +               |  73        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |    X  X           X                                                      |      5     |
      Inflammation, Chronic                |                                                          2               |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |             2                                                            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      C-Cell, Hyperplasia                  |    2     3           2     3  3  2  3     2     2  2  1                  |     39  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Inflammation, Chronic                |                            2              1                              |      3  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |                                                 X                        |      5     |
      Follicle, Cyst                       |                                                                          |      1     |
      Interstitium, Hyperplasia            |                1     1                 1  1     1                        |     44  1.2|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Dilatation                           |          2                                                               |      5  1.8|
      Cervix, Cyst                         |                                                                          |      1     |
      Endometrium, Hyperplasia             |                   2                                                      |      1  2.0|
      Wall, Hyperplasia                    |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                        +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|              |            |
                                           | 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Hyperplasia, Cystic                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Abscess                              |                                                       4                  |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Gliosis                              |                                                                          |      1  2.0|
      Hypothalamus, Compression            |                X                    X  X  X                              |     12     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  94        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  94        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                           1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   2        |
      Synechia                             |                                                                          |      1  3.0|
      Lens, Cataract                       |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Infarct                              |             2                                                            |      1  2.0|
      Nephropathy                          |    1                 1              1  1  1  1  1     1                  |     34  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 5| 9| 5| 2| 9| 1| 2| 4| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|              |            |
                                           | 9| 0| 1| 9| 9| 8| 2| 9| 6| 9| 9| 9| 9| 9| 3| 9| 9| 9| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    300 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|             
                             DAY ON TEST   | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|             
                                           | 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    23 STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Basophilic Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Myocardium, Degeneration             |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Hyperplasia                          |                      1                                                   |             
      Vacuolization Cytoplasmic            |                         2        2     1                 2     2         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +     +  M     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           | 1                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      C-Cell, Hyperplasia                  |          2  2        2                       3     2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Inflammation, Chronic                | 1                                                                        |             
      Inflammation, Chronic Active         |                      1                       1                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 2| 4| 4| 2| 0| 4| 0| 0| 2| 0| 0| 0| 2| 4| 0| 4| 4| 0| 2| 0| 4| 2| 0|             
                             DAY ON TEST   | 7| 5| 7| 5| 5| 7| 9| 5| 9| 9| 7| 9| 9| 9| 7| 5| 9| 5| 5| 9| 7| 9| 5| 7| 9|             
                                           | 4| 7| 8| 6| 6| 4| 7| 6| 3| 7| 4| 3| 3| 2| 4| 6| 7| 6| 7| 2| 8| 3| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    23 STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitium, Hyperplasia            | 1                       4     1  3  2  2                 3     3         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
      Nephropathy                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +     +  +     +  +  +  +  +  +     +     +     +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 1| 1| 1| 1| 1|             
                             DAY ON TEST   | 5| 9| 2| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 6| 6| 6| 6| 6|             
                                           | 6| 2| 2| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|             
    600 PPM                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 3| 3| 3| 3|             
    23 STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Basophilic Focus                     |       X                                                                  |             
      Hepatodiaphragmatic Nodule           |       3              X                                X                  |             
      Inflammation, Granulomatous          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Fat, Necrosis                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Myocardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | M  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Hyperplasia                          |       2     1                                                            |             
      Vacuolization Cytoplasmic            |    2     1           2                                   2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | M  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +     +     +  +  M           +  M  M  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                    1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      C-Cell, Hyperplasia                  | 1     1                    2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 0| 4| 4| 4| 0| 2| 4| 2| 2| 4| 0| 2| 2| 2| 2| 2| 0| 1| 1| 1| 1| 1|             
                             DAY ON TEST   | 5| 9| 2| 9| 5| 5| 5| 9| 7| 5| 7| 7| 5| 9| 7| 7| 7| 7| 7| 9| 6| 6| 6| 6| 6|             
                                           | 6| 2| 2| 2| 6| 6| 7| 2| 8| 6| 4| 4| 7| 7| 8| 4| 4| 4| 4| 3| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|             
    600 PPM                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 3| 3| 3| 3|             
    23 STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitium, Hyperplasia            |    2     3           2        1                 1        2               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Dilatation                           | 1                                                                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
      Inflammation                         |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Hyperplasia, Cystic                  |                2                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Inflammation, Chronic                |       3                                                                  |             
      Ulcer                                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  M  +     +     +  +  +           +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
      Nephropathy                          |                                  1           1  1  1  1                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +     +  +  +           +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    600 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    23 STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Myocardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    600 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    23 STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Nephropathy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
    23 STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  30        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  30        |
      Basophilic Focus                     |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      4  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  30        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  30        |
      Myocardium, Degeneration             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                                                                          |  29        |
      Hyperplasia                          |                                                                          |      3  1.3|
      Vacuolization Cytoplasmic            |                                                                          |      9  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                                                          |  29        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  30        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  30        |
      C-Cell, Hyperplasia                  |                                                                          |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
    23 STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  30        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  30        |
      Interstitium, Hyperplasia            |                                                                          |     14  2.1|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  30        |
      Dilatation                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  30        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  30        |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  30        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  29        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |  45        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  30        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
    23 STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  30        |
      Nephropathy                          |                                                                          |      6  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  30        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 0| 4| 4| 0| 4| 2| 0| 4| 4| 4| 0| 4| 2| 2| 2| 2| 4| 0| 0| 0| 2| 2| 0|             
                             DAY ON TEST   | 7| 7| 9| 5| 5| 9| 5| 7| 8| 5| 5| 5| 9| 5| 7| 7| 7| 7| 5| 9| 9| 9| 7| 7| 9|             
                                           | 3| 3| 2| 5| 5| 6| 7| 8| 7| 5| 5| 7| 3| 5| 8| 3| 3| 8| 5| 6| 2| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Venule, Parasite Metazoan            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Basophilic Focus                     |                               X                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |          1                                                               |             
      Eosinophilic Focus                   |          X  X                                                            |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                                                   1      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                             +                                          |             
      Inflammation, Chronic                | 1                                                                        |             
      Fat, Necrosis                        |                               2                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Inflammation, Chronic                |    1                                            2                        |             
      Acinus, Atrophy                      |             2                          1              1                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Degeneration                         | 2  1                                         2                       2   |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Intima, Hyperplasia                  |                                                                          |             
      Myocardium, Degeneration             |          1  1              1  1     1  2              2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 0| 4| 4| 0| 4| 2| 0| 4| 4| 4| 0| 4| 2| 2| 2| 2| 4| 0| 0| 0| 2| 2| 0|             
                             DAY ON TEST   | 7| 7| 9| 5| 5| 9| 5| 7| 8| 5| 5| 5| 9| 5| 7| 7| 7| 7| 5| 9| 9| 9| 7| 7| 9|             
                                           | 3| 3| 2| 5| 5| 6| 7| 8| 7| 5| 5| 7| 3| 5| 8| 3| 3| 8| 5| 6| 2| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +           M  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                       2                  |             
      Pars Distalis, Mineralization        |          1                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      C-Cell, Hyperplasia                  |          1  2              2  1        2              1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    1                                         1                       1   |             
      Inflammation, Chronic Active         |          1  2              2  1        1              1                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Inflammation, Chronic Active         |    1                                            1                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +           +  +  M     +  +     +  +     +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +           M  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Dermis, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 0| 4| 4| 0| 4| 2| 0| 4| 4| 4| 0| 4| 2| 2| 2| 2| 4| 0| 0| 0| 2| 2| 0|             
                             DAY ON TEST   | 7| 7| 9| 5| 5| 9| 5| 7| 8| 5| 5| 5| 9| 5| 7| 7| 7| 7| 5| 9| 9| 9| 7| 7| 9|             
                                           | 3| 3| 2| 5| 5| 6| 7| 8| 7| 5| 5| 7| 3| 5| 8| 3| 3| 8| 5| 6| 2| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X        X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Inflammation, Suppurative            |                         3                                                |             
      Nares, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Inflammation, Chronic                |                                                                          |             
      Lens, Cataract                       |                                        4                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
      Nephropathy                          | 1        1  1              2  1        1              2           1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +           +  +  +     +  +     +  +     +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 4| 2| 0| 4| 0| 0| 0| 4| 0| 0| 4| 2| 2| 2| 0| 4| 2| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 5| 5| 7| 9| 5| 9| 9| 9| 5| 9| 9| 5| 7| 7| 7| 9| 5| 7| 5| 7| 3| 3| 3| 3|             
                                           | 3| 5| 7| 3| 6| 7| 3| 2| 3| 7| 6| 2| 5| 8| 3| 8| 2| 5| 3| 5| 8| 1| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|             
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Venule, Parasite Metazoan            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  M|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                   1      |             
      Eosinophilic Focus                   |                                                                   X      |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |    1                                1                    1  2        2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Degeneration                         |          1                                1           1                  |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                                   X      |             
      Intima, Hyperplasia                  |                                                                          |             
      Myocardium, Degeneration             |                                  1              2        1  2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                       2  1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 4| 2| 0| 4| 0| 0| 0| 4| 0| 0| 4| 2| 2| 2| 0| 4| 2| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 5| 5| 7| 9| 5| 9| 9| 9| 5| 9| 9| 5| 7| 7| 7| 9| 5| 7| 5| 7| 3| 3| 3| 3|             
                                           | 3| 5| 7| 3| 6| 7| 3| 2| 3| 7| 6| 2| 5| 8| 3| 8| 2| 5| 3| 5| 8| 1| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|             
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                1     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Mineralization        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     1                       1     3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |          1                                            1                 2|             
      Inflammation, Chronic Active         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                                                     |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +        +  +  +        +  +     +     +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Dermis, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 4| 2| 0| 4| 0| 0| 0| 4| 0| 0| 4| 2| 2| 2| 0| 4| 2| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 5| 5| 7| 9| 5| 9| 9| 9| 5| 9| 9| 5| 7| 7| 7| 9| 5| 7| 5| 7| 3| 3| 3| 3|             
                                           | 3| 5| 7| 3| 6| 7| 3| 2| 3| 7| 6| 2| 5| 8| 3| 8| 2| 5| 3| 5| 8| 1| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 4|             
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nares, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Inflammation, Chronic                |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    1                                1              1  1  1  2  3  2  2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +        +  +  +        +  +     +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 4| 3| 2| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3|             
                                           | 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 1| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                 X                    X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Venule, Parasite Metazoan            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                            X                                             |             
      Degeneration, Cystic                 |                   1                 1              1     2               |             
      Eosinophilic Focus                   |                X  X        X     X                       X              X|             
      Fatty Change                         |                                                 2                        |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                1                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                             +                       +               |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |    3                                                     2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      | 1  1  2     2           1  1                 2  1     2  2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                 2                    3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                               3                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Atrium, Dilatation                   |             4                                                            |             
      Atrium, Thrombosis                   |                                                             X            |             
      Intima, Hyperplasia                  |                                        3                                 |             
      Myocardium, Degeneration             |    2  2  2  3  3  3  2  2        2  2  2  3  2     3  1  1  2  3  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                    1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 4| 3| 2| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3|             
                                           | 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 1| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2              2                    3        2        4               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      Pars Distalis, Hyperplasia           |                                  1  1                                    |             
      Pars Distalis, Mineralization        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  2        1  2        2     1  3           2  2     2  3     2     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
      Inflammation, Chronic                | 3                             2     2  2     2     3              2      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     3                                    |             
      Fibrosis                             |                   2     2                          2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Mineralization               |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 4| 3| 2| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3|             
                                           | 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 1| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0 PPM                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nares, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +        +        +                                                   |             
      Inflammation, Chronic                |             3                                                            |             
      Lens, Cataract                       | 4                    2                                                   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  1  3  2  1  3  1  1     1  3  1  2  2  2  2  4  2  1  1  2  2  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 5|              |            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 3| 4| 3| 3| 3| 0| 8| 8| 3| 3| 3| 7| 3| 0| 5|              |            |
                                           | 2| 5| 6| 2| 2| 2| 7| 2| 2| 2| 0| 3| 0| 2| 2| 2| 3| 2| 2| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  79        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Parasite Metazoan                    |             X        X                                   X               |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  78        |
      Venule, Parasite Metazoan            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Basophilic Focus                     |                         X  X                                             |      3     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |             1                                                            |      7  1.1|
      Eosinophilic Focus                   |                                                                          |      9     |
      Fatty Change                         |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                         X     X  X                                       |      5     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                            X                                             |      1     |
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   6        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Fat, Necrosis                        |                   2                                                      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Acinus, Atrophy                      |                      2  3  1  1           1  2     2  2                  |     26  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Degeneration                         |                                                                          |      7  1.4|
      Atrium, Dilatation                   |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      2     |
      Intima, Hyperplasia                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 5|              |            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 3| 4| 3| 3| 3| 0| 8| 8| 3| 3| 3| 7| 3| 0| 5|              |            |
                                           | 2| 5| 6| 2| 2| 2| 7| 2| 2| 2| 0| 3| 0| 2| 2| 2| 3| 2| 2| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Degeneration             |    1        3  2     3  2     1  2  2  1  2        1  2  3               |     48  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Hyperplasia                          | 2              3                       2              2  1               |      9  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Hyperplasia                          |    1                       2                                             |     11  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  M  M  +  +  M  +  M  +  +  +  +  +  +  +               |  73        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      3  1.3|
      Pars Distalis, Mineralization        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      C-Cell, Hyperplasia                  | 3  2  1        2        3     3        2     2  2        2               |     32  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                           2                              |     14  1.8|
      Inflammation, Chronic Active         |                                                                          |      7  1.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Atrophy                              |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                             +           +                        |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 5|              |            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 3| 4| 3| 3| 3| 0| 8| 8| 3| 3| 3| 7| 3| 0| 5|              |            |
                                           | 2| 5| 6| 2| 2| 2| 7| 2| 2| 2| 0| 3| 0| 2| 2| 2| 3| 2| 2| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  75        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Dermis, Mineralization               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hypothalamus, Compression            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
      Cyst                                 |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |    2                                   1                                 |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Suppurative            |                                              2                           |      2  2.5|
      Nares, Hemorrhage                    |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                +                                 |   8        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Lens, Cataract                       |                                        4                                 |      4  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Nephropathy                          | 1  1  1  2  1  2  1     2  1  1  3     1  2  1  2  1  2  3               |     62  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 2| 0| 4| 2| 4| 4| 0| 4| 4| 2| 4| 2| 2| 0| 2| 2| 0| 0| 0| 2| 4| 0|             
                             DAY ON TEST   | 9| 9| 9| 7| 9| 5| 7| 5| 5| 9| 5| 5| 7| 5| 7| 7| 9| 7| 7| 9| 9| 9| 7| 5| 9|             
                                           | 3| 6| 6| 3| 2| 5| 3| 7| 5| 2| 5| 7| 8| 7| 8| 3| 3| 8| 3| 6| 3| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    75 PPM                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                1        1     1                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Degeneration                         |          1        1                          1        1           1      |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             |                1        1     2                                1     1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 2| 0| 4| 2| 4| 4| 0| 4| 4| 2| 4| 2| 2| 0| 2| 2| 0| 0| 0| 2| 4| 0|             
                             DAY ON TEST   | 9| 9| 9| 7| 9| 5| 7| 5| 5| 9| 5| 5| 7| 5| 7| 7| 9| 7| 7| 9| 9| 9| 7| 5| 9|             
                                           | 3| 6| 6| 3| 2| 5| 3| 7| 5| 2| 5| 7| 8| 7| 8| 3| 3| 8| 3| 6| 3| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    75 PPM                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +  +     +  +  +              M  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Degeneration, Focal   |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2              2                                      2   |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1           1     1                          1        1     1            |             
      Inflammation, Chronic Active         |                3              1                                      1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |          1        1                          1                    1      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  M  M  +     +  +  +              +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 2| 0| 4| 2| 4| 4| 0| 4| 4| 2| 4| 2| 2| 0| 2| 2| 0| 0| 0| 2| 4| 0|             
                             DAY ON TEST   | 9| 9| 9| 7| 9| 5| 7| 5| 5| 9| 5| 5| 7| 5| 7| 7| 9| 7| 7| 9| 9| 9| 7| 5| 9|             
                                           | 3| 6| 6| 3| 2| 5| 3| 7| 5| 2| 5| 7| 8| 7| 8| 3| 3| 8| 3| 6| 3| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    75 PPM                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axon, Degeneration                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +  +     +  +  +              +  +     +     +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          |          1     2  1     1     2                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +  +     +  +  +              +  +     +     +  +  M  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 4| 2| 0| 4| 0| 0| 2| 4| 2| 4| 4| 4| 0| 2| 4| 4| 5| 5| 6| 7| 6|             
                             DAY ON TEST   | 7| 9| 7| 7| 5| 7| 9| 5| 9| 9| 7| 5| 7| 5| 5| 5| 9| 7| 5| 5| 9| 3| 1| 3| 9|             
                                           | 8| 3| 8| 3| 5| 3| 6| 5| 6| 2| 3| 7| 3| 5| 5| 5| 2| 3| 5| 7| 0| 7| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5|             
    75 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |             X                                                            |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                      X   |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Hyperplasia                          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                   4      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                    1                     |             
      Acinus, Atrophy                      |             1                                         1     2        1  2|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Degeneration                         |          1     1              2     1              1                     |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             |             2        2     1           1  1  1  1     1        1  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                       1           1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 4| 2| 0| 4| 0| 0| 2| 4| 2| 4| 4| 4| 0| 2| 4| 4| 5| 5| 6| 7| 6|             
                             DAY ON TEST   | 7| 9| 7| 7| 5| 7| 9| 5| 9| 9| 7| 5| 7| 5| 5| 5| 9| 7| 5| 5| 9| 3| 1| 3| 9|             
                                           | 8| 3| 8| 3| 5| 3| 6| 5| 6| 2| 3| 7| 3| 5| 5| 5| 2| 3| 5| 7| 0| 7| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5|             
    75 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +  +     M     +  +     +  +  +  +  +  +  +     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Degeneration, Focal   |                                                                          |             
      Pars Distalis, Hyperplasia           |                                        1                       1         |             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2                          2  2  2        2        2     2  2|             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              1                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Chronic                |          1     1                    1                          3         |             
      Inflammation, Chronic Active         |                      2                 1                                 |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Fibrosis                             |                                                                      3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  +     M     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 4| 2| 0| 4| 0| 0| 2| 4| 2| 4| 4| 4| 0| 2| 4| 4| 5| 5| 6| 7| 6|             
                             DAY ON TEST   | 7| 9| 7| 7| 5| 7| 9| 5| 9| 9| 7| 5| 7| 5| 5| 5| 9| 7| 5| 5| 9| 3| 1| 3| 9|             
                                           | 8| 3| 8| 3| 5| 3| 6| 5| 6| 2| 3| 7| 3| 5| 5| 5| 2| 3| 5| 7| 0| 7| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5|             
    75 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  M     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +  +     +     +  +     +  +  +  +  +  M  +     +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axon, Degeneration                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +              +            |             
      Lens, Cataract                       |                                                             4            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Infarct                              |                                                                2         |             
      Nephropathy                          |          1  1        2        1        2     1        1     2  1  1  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +     +     +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 0| 3| 3| 3| 3|             
                                           | 0| 6| 2| 5| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 5| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    75 PPM                                 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X     X        X                 X                           |             
      Clear Cell Focus                     |                   X                                                      |             
      Degeneration, Cystic                 |                                        1                                 |             
      Eosinophilic Focus                   |                         X                                      X         |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Hyperplasia                          |       3                                                                  |             
      Mixed Cell Focus                     |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +              +                       +|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                         3        2              3                       2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      | 1  1        2        2  1     2  1  1  2     1  2  1  1     2           1|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Artery, Inflammation, Chronic        |                3                                                         |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             | 2        2  1  3  2  3  3  3  3  2  2  3  1  2  1  2  3  2  3  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |       3  1  2     2        2     2           2           1  1            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3  4                                      2     3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 0| 3| 3| 3| 3|             
                                           | 0| 6| 2| 5| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 5| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    75 PPM                                 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X        X      |             
      Pars Distalis, Degeneration, Focal   |                                                                2         |             
      Pars Distalis, Hyperplasia           |                                  1           1     1                     |             
      Pars Distalis, Inflammation, Chronic |                                                                         1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     4  3  2  3     2  3  2  2     3  2  2  2  2           3  2  2  2  3|             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |             3        3  1     2        2        2              2         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                     4  4                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                 +     +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                           3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               3                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Infarct                              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 0| 3| 3| 3| 3|             
                                           | 0| 6| 2| 5| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 5| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    75 PPM                                 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                           3                              |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                          3               |             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axon, Degeneration                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2              1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Lens, Cataract                       |                                  4                                       |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 3  1  1  1  1  4  1  2     2  2  2  2  2  2  2  1  3  1  2  2  1  2  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3|              |            |
                                           | 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    75 PPM                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |  79        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |  79        |
      Ulcer                                |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Basophilic Focus                     |    X                 X                 X                                 |      8     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |             X                                                            |      4     |
      Fatty Change                         |                            2                                             |      1  2.0|
      Hepatodiaphragmatic Nodule           |                X     X                                   X               |      5     |
      Hyperplasia                          |                                                       2                  |      2  2.5|
      Mixed Cell Focus                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                          +              +                     |   8        |
      Inflammation, Chronic                |          2                                                               |      1  2.0|
      Fat, Necrosis                        |                                     3              2                     |      7  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Atrophy                      | 3              1                    1           1     2                  |     28  1.4|
      Acinus, Hyperplasia                  |    2                                   3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                               2                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Degeneration                         |                                                                          |     10  1.1|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                          X               |      1     |
      Myocardium, Degeneration             | 1     2  3  2  2     1     2  1  1  1  2  2  2  2     1  2               |     55  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3|              |            |
                                           | 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    75 PPM                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Hyperplasia                          |             2              1        1     1     2                        |     17  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |                                                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  72        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |                                                                          |      2     |
      Pars Distalis, Degeneration, Focal   |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                       2                  |      6  1.2|
      Pars Distalis, Inflammation, Chronic |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      C-Cell, Hyperplasia                  | 3  2  2  2  2  2        2           3     3  3  3  2                     |     42  2.3|
      Follicle, Dilatation                 |    3                       3                       3                     |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M               |  79        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |       2        1        2  2        2        2                           |     23  1.7|
      Inflammation, Chronic Active         |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Abscess                              |                   4                                                      |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Seminiferous Tubule, Atrophy         |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                             +                 +                        |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  79        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3|              |            |
                                           | 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    75 PPM                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Fibrosis                             |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |    1                                                                     |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M               |  77        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  75        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Abscess                              |                                                    3                     |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Infarct                              |                3                                                         |      1  3.0|
      Hypothalamus, Compression            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
      Axon, Degeneration                   |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                      1                    1                              |      4  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Suppurative            |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  79        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   4        |
      Lens, Cataract                       |          2                                                               |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 2| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7|              |            |
                             DAY ON TEST   | 0| 3| 3| 4| 3| 5| 6| 3| 1| 1| 9| 9| 3| 3| 3| 3| 3| 3| 5| 3|              |            |
                                           | 1| 1| 1| 8| 1| 5| 3| 1| 1| 4| 9| 8| 1| 1| 1| 1| 1| 1| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    75 PPM                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          | 2  1  1  2  1  1     3  2  2  3  1  2  3  3  2  1  4  1  3               |     61  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 4| 4| 4| 0| 4| 2| 0| 0| 2| 4| 4| 0| 4| 0| 0| 2| 0| 2| 2| 0| 0|             
                             DAY ON TEST   | 7| 9| 7| 7| 5| 5| 5| 9| 5| 7| 9| 9| 7| 5| 5| 9| 5| 9| 9| 7| 9| 7| 7| 9| 9|             
                                           | 3| 3| 8| 3| 7| 5| 5| 2| 5| 3| 6| 6| 8| 7| 7| 3| 5| 6| 3| 8| 3| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150 PPM                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Degeneration                         | 1        1                 1                                   2  1      |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             |    1           2        2                    1  2           1           1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 4| 4| 4| 0| 4| 2| 0| 0| 2| 4| 4| 0| 4| 0| 0| 2| 0| 2| 2| 0| 0|             
                             DAY ON TEST   | 7| 9| 7| 7| 5| 5| 5| 9| 5| 7| 9| 9| 7| 5| 5| 9| 5| 9| 9| 7| 9| 7| 7| 9| 9|             
                                           | 3| 3| 8| 3| 7| 5| 5| 2| 5| 3| 6| 6| 8| 7| 7| 3| 5| 6| 3| 8| 3| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150 PPM                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                1                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                3  2     2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Hypospermia                          |                                                                         X|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   1      |             
      Inflammation, Chronic Active         |                         2                       1                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1        1     1           1                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Hypospermia                          |                                                                         X|             
      Seminiferous Tubule, Atrophy         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 2| 2| 4| 4| 4| 0| 4| 2| 0| 0| 2| 4| 4| 0| 4| 0| 0| 2| 0| 2| 2| 0| 0|             
                             DAY ON TEST   | 7| 9| 7| 7| 5| 5| 5| 9| 5| 7| 9| 9| 7| 5| 5| 9| 5| 9| 9| 7| 9| 7| 7| 9| 9|             
                                           | 3| 3| 8| 3| 7| 5| 5| 2| 5| 3| 6| 6| 8| 7| 7| 3| 5| 6| 3| 8| 3| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150 PPM                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Inflammation, Suppurative            |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Ulcer                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
      Nephropathy                          |                2  1     2                       1              1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +     +  +  +  +  +                 +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 2| 4| 4| 0| 2| 2| 4| 4| 4| 4| 2| 0| 0| 0| 2| 2| 0| 4| 2| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 5| 7| 5| 5| 9| 7| 7| 5| 5| 5| 5| 7| 9| 9| 9| 7| 7| 9| 5| 7| 0| 5| 2| 2| 2|             
                                           | 5| 8| 5| 7| 2| 8| 3| 5| 5| 5| 7| 3| 6| 2| 3| 3| 3| 6| 5| 3| 1| 3| 9| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|             
    150 PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +     +  +  +  +     +     +  +  +  +     +  +  M  +  +  +  +|             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                             1            |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Hyperplasia                          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                             2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   1                                      2               |             
      Acinus, Atrophy                      | 1                       1                                            2  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                  X                                       |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Degeneration                         |                   1              2           1                           |             
      Atrium, Thrombosis                   |                                                             X            |             
      Myocardium, Degeneration             | 3     1     1        1  2  1                          2     3  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                             1                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 2| 4| 4| 0| 2| 2| 4| 4| 4| 4| 2| 0| 0| 0| 2| 2| 0| 4| 2| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 5| 7| 5| 5| 9| 7| 7| 5| 5| 5| 5| 7| 9| 9| 9| 7| 7| 9| 5| 7| 0| 5| 2| 2| 2|             
                                           | 5| 8| 5| 7| 2| 8| 3| 5| 5| 5| 7| 3| 6| 2| 3| 3| 3| 6| 5| 3| 1| 3| 9| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|             
    150 PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     2              3  3  2                          1           3  3  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +     +     +  +  +  +     +     M     +  +     +  +  M  +  +  +  +|             
      Inflammation, Chronic                |                                              1           1              3|             
      Inflammation, Chronic Active         | 1     2              1  1  1                          1                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             4        3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +     +     +  +  +  +     +     +  +  +  +     +  +  M  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 2| 4| 4| 0| 2| 2| 4| 4| 4| 4| 2| 0| 0| 0| 2| 2| 0| 4| 2| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 5| 7| 5| 5| 9| 7| 7| 5| 5| 5| 5| 7| 9| 9| 9| 7| 7| 9| 5| 7| 0| 5| 2| 2| 2|             
                                           | 5| 8| 5| 7| 2| 8| 3| 5| 5| 5| 7| 3| 6| 2| 3| 3| 3| 6| 5| 3| 1| 3| 9| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|             
    150 PPM                                | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Ulcer                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
      Nephropathy                          | 1     1              2  1  1     1           1  1     2     2  1  3  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +     +  +  +  +     +     +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 2| 3|             
                                           | 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 0| 4| 0| 0| 0| 0| 9| 0| 0| 0| 8| 2| 4| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    150 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X        X                 X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                 X  X        X  X               |             
      Clear Cell Focus                     |                                                    X                     |             
      Degeneration, Cystic                 |                                     1                                    |             
      Eosinophilic Focus                   |    X           X                    X  X                                 |             
      Fatty Change                         |                                                 3                        |             
      Hepatodiaphragmatic Nodule           |       X                                                                  |             
      Hyperplasia                          |                                                                   2     4|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                 +                                   +   |             
      Fat, Necrosis                        |                                  2                                   3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      | 2              2     2  1  1  2        2              1     2  2  2     2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                 4                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
      Epithelium, Hyperplasia              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Atrium, Thrombosis                   |                                                                      X   |             
      Myocardium, Degeneration             | 1     2  3  2     4  2  3  1  1  2     2     2  3  2  1  2  1  1     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2  2                                   1        2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 2| 3|             
                                           | 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 0| 4| 0| 0| 0| 0| 9| 0| 0| 0| 8| 2| 4| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    150 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |             3        4                 4           2  2        2     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    3  2        1  2  2     2  1  2  1  2  2  2  2  3  2     2  2  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2                       2  2  2              2     3     2         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +     +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                         2        3                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 2| 3|             
                                           | 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 0| 4| 0| 0| 0| 0| 9| 0| 0| 0| 8| 2| 4| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    150 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                  X              X                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Inflammation, Chronic                |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2           1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Ulcer                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    2  2  2  2  2  1  2  2  1  1  1  1  1  2  2  3  2  2  2  2  1  1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 6| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1|              |            |
                                           | 0| 0| 0| 0| 0| 0| 1| 9| 2| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    150 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
      Parasite Metazoan                    | X           X  X                       X                                 |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  78        |
      Ulcer                                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Basophilic Focus                     |                X                                                         |      6     |
      Clear Cell Focus                     |             X                                                            |      2     |
      Degeneration, Cystic                 |                               2  3     1        1     1                  |      7  1.4|
      Eosinophilic Focus                   |                X        X                          X                     |      7     |
      Fatty Change                         |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |       X              X                                X                  |      5     |
      Hyperplasia                          |                                                                          |      2  3.0|
      Mixed Cell Focus                     |                               X                                          |      1     |
      Necrosis                             |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +              +                        |   5        |
      Fat, Necrosis                        |                                  2              3                        |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Acinus, Atrophy                      | 1     1  1     2        2        3                 1     2               |     24  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Ulcer                                |                         3        3                                       |      3  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Degeneration                         |                                                                          |      8  1.3|
      Atrium, Thrombosis                   |                                                                          |      2     |
      Myocardium, Degeneration             | 2  1  3  3  2  2  2           4  3  2  3  2  2     2  2  2               |     54  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 6| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1|              |            |
                                           | 0| 0| 0| 0| 0| 0| 1| 9| 2| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    150 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |             3           4     2     1                                    |     10  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hyperplasia                          |       3     2                 2        2  1        3                     |      6  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  76        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Pars Distalis, Hyperplasia           |             2                                                            |     10  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      C-Cell, Hyperplasia                  | 3  2  2  2  2  2           2  3  2  2     3  2  2  2  2  1               |     48  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hypospermia                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  77        |
      Inflammation, Chronic                |                         3     2              3                           |     14  2.1|
      Inflammation, Chronic Active         |                                                                          |      8  1.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hypospermia                          |                                                                          |      1     |
      Seminiferous Tubule, Atrophy         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                  +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst                                 |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Fibrosis                             |                         2  2                                             |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 6| 8| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1|              |            |
                                           | 0| 0| 0| 0| 0| 0| 1| 9| 2| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    150 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|              |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  77        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +               |  75        |
      Hyperplasia, Cystic                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Cyst Epithelial Inclusion            |                                                       X                  |      1     |
      Ulcer                                |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Hypothalamus, Compression            |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  93        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  95        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Erythrophagocytosis                  |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Inflammation, Suppurative            |                                                    2                     |      4  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  79        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
      Pinna, Ulcer                         |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +                           |   1        |
      Phthisis Bulbi                       |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
      Nephropathy                          | 2  2  2  2  1  2        4  2  3  1  1  2  3  1  2     1  1               |     60  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  80        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 4| 0| 2| 4| 2| 4| 4| 2| 2| 2| 0| 4| 0| 0| 2| 2| 4| 4| 2| 0| 4| 2| 2|             
                             DAY ON TEST   | 9| 7| 5| 9| 7| 5| 7| 5| 5| 7| 7| 7| 9| 5| 9| 9| 7| 7| 5| 5| 7| 9| 5| 7| 7|             
                                           | 3| 3| 7| 3| 3| 5| 3| 5| 7| 3| 3| 8| 2| 5| 6| 6| 3| 3| 5| 5| 3| 3| 5| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                   X        X                             X  X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +     +            |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis                        |                                                       3     3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                   1                             1                        |             
      Acinus, Atrophy                      |                                                       1                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Degeneration                         |    1        1                 1                 1           1        2   |             
      Atrium, Dilatation                   |                                                                          |             
      Myocardium, Degeneration             |                1     3                 3              2  2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                1                                                     1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 4| 0| 2| 4| 2| 4| 4| 2| 2| 2| 0| 4| 0| 0| 2| 2| 4| 4| 2| 0| 4| 2| 2|             
                             DAY ON TEST   | 9| 7| 5| 9| 7| 5| 7| 5| 5| 7| 7| 7| 9| 5| 9| 9| 7| 7| 5| 5| 7| 9| 5| 7| 7|             
                                           | 3| 3| 7| 3| 3| 5| 3| 5| 7| 3| 3| 8| 2| 5| 6| 6| 3| 3| 5| 5| 3| 3| 5| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |                2     2                 2              2  2        2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +  +  +     +  +     +  M        +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |             1              1                       1                     |             
      Inflammation, Chronic Active         |                1     1                                   1        1      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                1  2                    1              1           1  1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Seminiferous Tubule, Atrophy         |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Fibrosis                             |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  M  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Abscess                              |                                                             3            |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 4| 0| 2| 4| 2| 4| 4| 2| 2| 2| 0| 4| 0| 0| 2| 2| 4| 4| 2| 0| 4| 2| 2|             
                             DAY ON TEST   | 9| 7| 5| 9| 7| 5| 7| 5| 5| 7| 7| 7| 9| 5| 9| 9| 7| 7| 5| 5| 7| 9| 5| 7| 7|             
                                           | 3| 3| 7| 3| 3| 5| 3| 5| 7| 3| 3| 8| 2| 5| 6| 6| 3| 3| 5| 5| 3| 3| 5| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    300 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nerve, Degeneration                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          |                1     1                 2              2  1        2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +     +  +     +  +        +  +  +  +  +  +  +  +   |             
      Mucosa, Ulcer                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 2| 4| 2| 0| 0| 0| 0| 0| 4| 0| 0| 4| 4| 2| 2| 4| 4| 4| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 9| 9| 7| 5| 7| 9| 9| 9| 9| 9| 5| 9| 9| 5| 5| 7| 7| 5| 5| 5| 8| 2| 2| 2| 9|             
                                           | 2| 3| 8| 5| 8| 6| 6| 2| 3| 6| 7| 2| 2| 7| 7| 8| 3| 5| 5| 5| 9| 9| 9| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 6| 6| 6| 6|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                X         |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                   2      |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             X     X      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                             2        2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                         2|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Cyst                                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Atrium, Dilatation                   |                                                                          |             
      Myocardium, Degeneration             | 1        2                       1  1              2  2  2  2     2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2  2         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 2| 4| 2| 0| 0| 0| 0| 0| 4| 0| 0| 4| 4| 2| 2| 4| 4| 4| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 9| 9| 7| 5| 7| 9| 9| 9| 9| 9| 5| 9| 9| 5| 5| 7| 7| 5| 5| 5| 8| 2| 2| 2| 9|             
                                           | 2| 3| 8| 5| 8| 6| 6| 2| 3| 6| 7| 2| 2| 7| 7| 8| 3| 5| 5| 5| 9| 9| 9| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 6| 6| 6| 6|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +     +           +  +        +  +           +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                          2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2                                         3  2  2        2  3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1                                1              1                        |             
      Inflammation, Chronic Active         |          2                                            1                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      2   |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +           +  +        +  +           +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 2| 4| 2| 0| 0| 0| 0| 0| 4| 0| 0| 4| 4| 2| 2| 4| 4| 4| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 9| 9| 7| 5| 7| 9| 9| 9| 9| 9| 5| 9| 9| 5| 5| 7| 7| 5| 5| 5| 8| 2| 2| 2| 9|             
                                           | 2| 3| 8| 5| 8| 6| 6| 2| 3| 6| 7| 2| 2| 7| 7| 8| 3| 5| 5| 5| 9| 9| 9| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 6| 6| 6| 6|             
    300 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                X         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nerve, Degeneration                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                             4     1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          |          1                                      1  1  1  1  1  4  3     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +           +  +        +  +           +  +  +  +  +  +  +  +  +|             
      Mucosa, Ulcer                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05100-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        TRICRESYL PHOSPHATE                                    Date: 04/24/97  
Route: DOSED FEED                                                                                                 Time: 12:16:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 4| 2| 2| 2| 2| 1| 1| 2| 3| 2| 2| 2| 3| 2| 7| 2| 7| 6| 2| 9| 2|             
                                           | 9| 5| 9| 9| 2| 9| 9| 9| 9| 4| 8| 9| 8| 9| 9| 9| 1| 9| 8| 9| 0| 2| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    300 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +