TDMS Study 05100-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95
EXPERIMENT: 05100 TEST: 03 TIME: 14:18:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45050 ROUTE: DOSED FEED NTP C#: 10277D
PATHOLOGIST: M. RYAN CAS: 1330-78-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRICRESYL PHOSPHATE DATE: 11/09/95
EXPERIMENT: 05100 TEST: 03 TIME: 14:18:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45050 ROUTE: DOSED FEED NTP C#: 10277D
PATHOLOGIST: M. RYAN CAS: 1330-78-5
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 19 CENSORED DEATHS 44 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 87 478 486 500 558 572 592 625 647 647 |
| 673 680 683 690 701 701 702 722 725 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 96 96 96 96 96 273 273 273 273 273 |
| 273 273 273 273 278 278 278 278 278 455 |
| 455 455 455 455 455 455 455 455 455 457 |
| 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 20 CENSORED DEATHS 45 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 263 455 498 537 586 590 611 614 614 635 |
| 640 648 652 662 690 691 699 701 702 725 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 96 96 96 96 96 273 273 273 273 273 |
| 273 273 273 273 273 278 278 278 278 278 |
| 455 455 455 455 455 455 455 455 455 455 |
| 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 15 CENSORED DEATHS 45 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 269 454 488 491 529 553 614 618 624 638 |
| 682 701 711 722 722 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 96 96 96 96 96 273 273 273 273 273 |
| 273 273 273 273 273 278 278 278 278 278 |
| 455 455 455 455 455 455 455 455 455 455 |
| 457 457 457 457 457 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 22 CENSORED DEATHS 45 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 498 542 578 589 605 614 614 618 628 631 |
| 638 640 656 662 670 670 691 697 702 705 |
| 711 712 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 96 96 96 96 96 273 273 273 273 273 |
| 273 273 273 273 273 278 278 278 278 278 |
| 455 455 455 455 455 455 455 455 455 455 |
| 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM 23 STOP |
| ---------------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 0 CENSORED DEATHS 95 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 96 96 96 96 96 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 273 273 273 273 273 |
| 273 273 273 273 273 278 278 278 278 278 |
| 455 455 455 455 455 455 455 455 455 455 |
| 457 457 457 457 457 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 98.9 98.9 98.9 98.9 98.9 97.0 93.0 87.1 81.1 63.3 |
| | |
| | |
|75 PPM | 100.0 100.0 98.8 98.8 98.8 97.2 93.2 89.1 72.9 60.8 |
| | |
| | |
|150 PPM | 100.0 100.0 98.8 98.8 98.8 97.2 91.1 89.1 81.0 70.9 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 72.0 56.0 |
| | |
| | |
|600 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 23 STOP| |
| | |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 75 PPM 150 PPM 300 PPM 600 |
| PPM 23 STOP |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.3% 60.8% 70.9% 56.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.908 P=0.868 P=0.604N P=0.606 P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.6 610.7 587.7 639.6 . |
|NATURAL DEATHS (C) | (34.0) (24.1) (32.5) (12.0) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 493.5 488.9 491.5 493.1 217.5 |
|(STANDARD ERROR) | (24.8) (24.4) (24.7) (24.2) (11.9) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 17 CENSORED DEATHS 44 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 134 412 488 502 537 553 557 564 578 592 |
| 619 638 652 667 675 712 722 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 97 97 97 97 97 274 274 274 274 274 |
| 274 274 274 274 274 278 278 278 278 278 |
| 456 456 456 456 456 456 456 456 456 457 |
| 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 15 CENSORED DEATHS 42 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 204 222 285 397 464 558 620 624 653 687 |
| 701 705 705 707 712 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 97 97 97 97 97 274 274 274 274 274 |
| 274 274 274 274 274 278 278 278 278 456 |
| 456 456 456 456 456 456 456 457 457 457 |
| 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 20 CENSORED DEATHS 45 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 372 592 611 619 624 637 642 653 666 670 |
| 670 697 704 705 705 705 705 712 722 724 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 97 97 97 97 97 274 274 274 274 274 |
| 274 274 274 274 274 278 278 278 278 278 |
| 456 456 456 456 456 456 456 456 456 456 |
| 457 457 457 457 457 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 23 CENSORED DEATHS 46 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 24 353 546 550 558 564 592 620 625 653 |
| 659 667 670 687 687 691 698 699 703 704 |
| 712 722 722 |
| CENSORED DEATHS |
| 2 92 92 92 92 92 92 93 93 93 |
| 93 93 97 97 97 97 274 274 274 274 |
| 274 274 274 274 274 274 278 278 278 278 |
| 278 456 456 456 456 456 456 456 456 456 |
| 456 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM 23 STOP |
| ---------------------------- |
| |
| TOTAL 95 UNCENSORED DEATHS 1 CENSORED DEATHS 94 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 422 |
| CENSORED DEATHS |
| 92 92 92 92 92 93 93 93 93 93 |
| 97 97 97 97 97 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 166 166 166 166 166 |
| 166 166 166 166 166 274 274 274 274 274 |
| 274 274 274 274 274 278 278 278 278 278 |
| 456 456 456 456 456 456 456 456 456 457 |
| 457 457 457 457 |
| |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 98.8 98.8 98.8 97.2 97.2 91.3 81.3 75.4 67.4 |
| | |
| | |
|75 PPM | 100.0 100.0 97.5 96.0 94.5 92.5 92.5 90.6 84.8 73.2 |
| | |
| | |
|150 PPM | 100.0 100.0 100.0 100.0 98.5 98.5 98.5 96.5 84.4 60.3 |
| | |
| | |
|300 PPM | 98.9 98.9 98.9 97.4 97.4 97.4 97.4 87.0 78.7 53.9 |
| | |
| | |
|600 | 100.0 100.0 100.0 100.0 93.3 0.0 0.0 0.0 0.0 0.0 |
|PPM 23 STOP| |
| | |
==================================================================================
TRICRESYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 75 PPM 150 PPM 300 PPM 600 |
| PPM 23 STOP |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 67.4% 73.2% 60.3% 53.9% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.190 P=0.681N P=0.877 P=0.357 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 564.8 549.6 656.8 613.3 422.0 |
|NATURAL DEATHS (C) | (33.5) (48.3) (17.5) (32.1) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 487.5 496.2 498.8 478.3 217.4 |
|(STANDARD ERROR) | (24.6) (25.3) (24.7) (25.1) (11.8) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRICRESYL PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
75 PPM = 2
150 PPM = 3
300 PPM = 4
600 PPM 23 STOP = 5
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 23 2 1 4
| 2 11 2 4
| 131 24 4 4
| 31 32 1 2 4 4
90 + 3 31 1 2 1 42
| 1 331
| 431 1
| 2 323
80 + 221 11 3
| 22 33
| 4 2 2 11 3 3
| 24 1 1
P 70 + 22 3 3
E | 4 421 1
R | 444
C | 2 1 1
E 60 + 44 2 2
N |
T | 4 4
|
S 50 +
U |
R |
V |
I 40 +
V |
A |
L |
30 +
|
|
|
20 +
|
|
|
10 +
|
|
|
0 + 5
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 43 obs hidden.
TRICRESYL PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
75 PPM = 2
150 PPM = 3
300 PPM = 4
600 PPM 23 STOP = 5
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 1 2 2 4 3 1 5
| 2 2 4 3 1 1 4 3 3
| 2 2 2 1 1 44 33
| 5 2 1 1 12 33
90 + 114 4 233
| 11 4 2233 2
| 1 1 44 2 3 2
| 1 1 14 4 2 2
80 + 1 1 4 4
| 1 1 43 33
| 1 1 4 22
| 11 1 2
P 70 + 1 1
E | 4433 1 1
R | 443 3
C |
E 60 + 44 3 3
N | 4 4
T | 4 4
|
S 50 +
U |
R |
V |
I 40 +
V |
A |
L |
30 +
|
|
|
20 +
|
|
|
10 +
|
|
|
0 + 5
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 27 obs hidden.