National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1699

TDMS Study 05102-06 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       BENZETHONIUM CHLORIDE


NTP Experiment-Test: 05102-06                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  121-54-0

       Lock Date:  01/22/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8            7           10            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10            4            8           13                                     
    Natural Death                                      3           15            9            7                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           34           31           34                                     
  Other                                                                          2                                                  
  Animals Examined Microscopically                    60           60           58           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)                                   (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Large, Rectum                            (60)                                   (59)                                   
      Liposarcoma, Metastatic, Skeletal Muscle                                                1 (2%)                                
   Intestine Large, Cecum                             (60)                                   (59)                                   
   Intestine Small, Jejunum                           (60)                                   (58)                                   
      Carcinoma                                        1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
   Liver                                              (60)                                   (60)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
      Hepatocellular Carcinoma                         7 (12%)                               10 (17%)                               
      Hepatocellular Carcinoma, Multiple               5 (8%)                                 1 (2%)                                
      Hepatocellular Adenoma                          10 (17%)                               13 (22%)                               
      Hepatocellular Adenoma, Multiple                11 (18%)                                6 (10%)                               
      Hepatocholangiocarcinoma, Multiple                                                      1 (2%)                                
      Histiocytic Sarcoma                              3 (5%)                                                                       
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                      1 (2%)                                                                       
   Mesentery                                          (10)                                   (9)                                    
      Hemangioma                                       1 (10%)                                                                      
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (11%)                               
      Histiocytic Sarcoma                              1 (10%)                                                                      
      Myxosarcoma, Metastatic, Skin                    1 (10%)                                                                      
   Pancreas                                           (60)                                   (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (2%)                                
   Salivary Glands                                    (60)                                   (60)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Forestomach                               (59)                                   (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)                                   (60)                                   
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)                                   (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Pituitary Gland                                    (60)                                   (55)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pars Distalis, Adenoma                           6 (10%)                                5 (9%)                                
   Thyroid Gland                                      (60)                                   (60)                                   
      Follicular Cell, Adenoma                         3 (5%)                                 1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (60)                                   (58)                                   
      Cystadenoma                                      3 (5%)                                 2 (3%)                                
      Hemangioma                                                                              1 (2%)                                
      Histiocytic Sarcoma                              2 (3%)                                                                       
   Uterus                                             (60)                                   (59)                                   
      Carcinoma                                                                               1 (2%)                                
      Histiocytic Sarcoma                              3 (5%)                                 1 (2%)                                
      Leiomyosarcoma                                                                          1 (2%)                                
      Polyp Stromal                                    1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                                     (1)                                    
   Bone Marrow                                        (60)                                   (59)                                   
      Hemangiosarcoma, Metastatic, Spleen                                                     3 (5%)                                
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
                                                             Page   3                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
           Spleen                                      1 (2%)                                                                       
   Lymph Node                                         (7)                                    (3)                                    
      Lumbar, Histiocytic Sarcoma                      1 (14%)                                                                      
      Mediastinal, Histiocytic Sarcoma                 1 (14%)                                                                      
      Pancreatic, Hepatocholangiocarcinoma,                                                                                         
          Metastatic, Liver                                                                   1 (33%)                               
   Lymph Node, Mandibular                             (60)                                   (60)                                   
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                              3 (5%)                                                                       
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                      1 (2%)                                                                       
   Lymph Node, Mesenteric                             (57)                                   (54)                                   
      Histiocytic Sarcoma                              3 (5%)                                                                       
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                      1 (2%)                                                                       
   Spleen                                             (60)                                   (59)                                   
      Hemangiosarcoma                                  1 (2%)                                 3 (5%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
   Thymus                                             (49)                                   (51)                                   
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (59)         (58)         (59)                                   
      Subcutaneous Tissue, Fibrosarcoma                2 (3%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
   Skin, Inguinal                                                  (2)          (1)          (1)                                    
   Skin, Site of Application-No Mass                  (5)          (10)         (9)          (27)                                   
      Subcutaneous Tissue, Hemangioma                  1 (20%)                                                                      
   Skin, Site of Application-Mass                     (1)                                    (1)                                    
      Subcutaneous Tissue, Myxosarcoma, Multiple       1 (100%)                                                                     
      Subcutaneous Tissue, Sarcoma                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)                                   (59)                                   
      Liposarcoma, Metastatic, Skeletal Muscle                                                1 (2%)                                
   Skeletal Muscle                                                                           (4)                                    
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (25%)                               
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (25%)                               
      Liposarcoma                                                                             1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Spinal Cord                                                                               (2)                                    
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)                                   (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                 2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                 1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      5 (8%)                                 3 (5%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Liposarcoma, Metastatic, Skeletal Muscle                                                1 (2%)                                
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (44)                                   (35)                                   
      Adenoma                                          2 (5%)                                 2 (6%)                                
      Carcinoma                                        2 (5%)                                 1 (3%)                                
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Histiocytic Sarcoma                              3 (5%)                                                                       
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Spleen                                      1 (2%)                                                                       
   Urinary Bladder                                    (58)                                   (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(58)        *(60)                                   
      Histiocytic Sarcoma                              3 (5%)                                 1 (2%)                                
      Leukemia Lymphocytic                                                                    1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)                    2 (3%)                                
      Lymphoma Malignant Mixed                         5 (8%)                                 3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42           1           1          43                                       
     Total Primary Neoplasms                           75           1           1          63                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29                                  29                                       
     Total Benign Neoplasms                            40                                  34                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27           1           1          27                                       
     Total Malignant Neoplasms                         35           1           1          29                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9                                   8                                       
     Total Metastatic Neoplasm                         16                                  16                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9            9           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            8            4            9                                     
    Natural Death                                      4            4            4            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           38           42           39                                     
  Other                                                             1            1                                                  
  Animals Examined Microscopically                    60           59           59           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (60)                                   (60)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Duodenum                          (60)                                   (60)                                   
      Adenoma                                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (60)                                   (60)                                   
   Liver                                              (60)                                   (60)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  2 (3%)                                                                       
      Hemangiosarcoma, Multiple                        1 (2%)                                 2 (3%)                                
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Hepatoblastoma                                                                          1 (2%)                                
      Hepatocellular Carcinoma                        10 (17%)                               14 (23%)                               
      Hepatocellular Carcinoma, Multiple               2 (3%)                                 2 (3%)                                
      Hepatocellular Adenoma                          15 (25%)                               16 (27%)                               
      Hepatocellular Adenoma, Multiple                13 (22%)                               13 (22%)                               
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Mesentery                                          (5)                                    (5)                                    
      Hemangioma                                       1 (20%)                                1 (20%)                               
      Histiocytic Sarcoma                                                                     1 (20%)                               
   Stomach, Glandular                                 (60)                                   (60)                                   
      Carcinoid Tumor Malignant                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)                                   (60)                                   
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)                                   (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Adrenal Medulla                                    (60)                                   (60)                                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (59)                                   (60)                                   
      Adenoma                                          2 (3%)                                 1 (2%)                                
   Pituitary Gland                                    (58)                                   (58)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thyroid Gland                                      (60)                                   (60)                                   
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)                                   (59)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Testes                                             (60)                                   (60)                                   
      Interstitial Cell, Adenoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)                                   (60)                                   
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (3)                                    (2)                                    
   Lymph Node, Mandibular                             (59)                                   (58)                                   
   Lymph Node, Mesenteric                             (57)                                   (57)                                   
   Spleen                                             (60)                                   (60)                                   
      Hemangiosarcoma                                                                         3 (5%)                                
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (41)                                   (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (59)         (59)         (60)                                   
      Melanoma Benign                                                                         1 (2%)                                
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma,                                                                                         
          Metastatic, Spleen                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)                                   (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)                                   (60)                                   
      Alveolar/Bronchiolar Adenoma                    11 (18%)                                7 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)                                 1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Multiple                                                2 (3%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                                 5 (8%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Nose                                               (60)                                   (60)                                   
      Glands, Carcinoma                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                    (2)                                    
      Fibrosarcoma                                     1 (100%)                               1 (50%)                               
   Harderian Gland                                    (43)                                   (38)                                   
      Adenoma                                          2 (5%)                                 3 (8%)                                
      Carcinoma                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(59)        *(59)        *(60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         1 (2%)                                 3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05102-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:39:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48                                  44                                       
     Total Primary Neoplasms                           72                                  81                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39                                  34                                       
     Total Benign Neoplasms                            49                                  47                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18                                  24                                       
     Total Malignant Neoplasms                         23                                  34                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                                   8                                       
     Total Metastatic Neoplasm                          8                                  11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.