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TDMS Study 05102-05 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       BENZETHONIUM CHLORIDE


NTP Experiment-Test: 05102-05                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  121-54-0

       Lock Date:  01/24/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  9            7            9            7                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           11           13           13                                     
    Natural Death                                     14            9           12           16                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           33           26           24                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (2)                                                                           
      Ulcer                                            2 (100%)                                                                     
   Liver                                              (60)                                   (60)                                   
      Angiectasis                                      2 (3%)                                                                       
      Basophilic Focus                                26 (43%)                               33 (55%)                               
      Clear Cell Focus                                 2 (3%)                                 7 (12%)                               
      Eosinophilic Focus                              13 (22%)                               13 (22%)                               
      Hepatodiaphragmatic Nodule                       9 (15%)                               18 (30%)                               
      Hepatodiaphragmatic Nodule, Multiple             1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)                                
      Inflammation, Granulomatous                      8 (13%)                               11 (18%)                               
      Bile Duct, Hyperplasia                          11 (18%)                               13 (22%)                               
      Hepatocyte, Degeneration, Cystic                                                        2 (3%)                                
      Hepatocyte, Hypertrophy, Focal                                                          1 (2%)                                
      Hepatocyte, Necrosis                             1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            7 (12%)                                8 (13%)                               
   Mesentery                                          (4)                                    (4)                                    
      Fat, Inflammation, Chronic Active                3 (75%)                                4 (100%)                              
   Pancreas                                           (60)                                   (60)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Acinus, Atrophy                                 15 (25%)                               17 (28%)                               
   Stomach, Forestomach                               (6)                                    (8)                                    
      Acanthosis                                                                              3 (38%)                               
      Inflammation, Chronic Active                                                            1 (13%)                               
      Mineralization                                                                          1 (13%)                               
      Ulcer                                            6 (100%)                               5 (63%)                               
   Stomach, Glandular                                 (1)                                                                           
      Necrosis                                         1 (100%)                                                                     
   Tongue                                                                                    (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)                                   (60)                                   
      Degeneration, Chronic                           29 (48%)                               33 (55%)                               
      Atrium, Thrombosis                               3 (5%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (19)                                   (21)                                   
      Degeneration, Cystic                             1 (5%)                                 1 (5%)                                
      Hyperplasia                                      7 (37%)                               12 (57%)                               
      Hypertrophy                                                                             1 (5%)                                
      Necrosis                                         2 (11%)                                2 (10%)                               
      Vacuolization Cytoplasmic                        8 (42%)                                9 (43%)                               
   Adrenal Medulla                                    (10)                                   (2)                                    
      Hyperplasia                                      6 (60%)                                1 (50%)                               
   Parathyroid Gland                                  (56)                                   (53)                                   
      Hyperplasia                                     32 (57%)                               32 (60%)                               
   Pituitary Gland                                    (60)                                   (60)                                   
      Necrosis                                         1 (2%)                                                                       
      Craniopharyngeal Duct, Pars Distalis, Cyst                                              1 (2%)                                
      Pars Distalis, Cyst                             11 (18%)                               12 (20%)                               
      Pars Distalis, Hyperplasia                      17 (28%)                               20 (33%)                               
   Thyroid Gland                                      (60)                                   (60)                                   
      Bilateral, Ultimobranchial Cyst                                                         1 (2%)                                
      C-Cell, Hyperplasia                             24 (40%)                               17 (28%)                               
      Follicular Cell, Hyperplasia                                                            2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)                                   (59)                                   
      Hyperplasia                                      5 (8%)                                 4 (7%)                                
      Inflammation, Chronic Active                     2 (3%)                                 1 (2%)                                
      Duct, Cyst                                       1 (2%)                                                                       
      Duct, Ectasia                                    1 (2%)                                 2 (3%)                                
   Ovary                                              (60)                                   (60)                                   
      Follicle, Cyst                                   4 (7%)                                 7 (12%)                               
      Periovarian Tissue, Cyst                         8 (13%)                               13 (22%)                               
   Uterus                                             (60)                                   (60)                                   
      Endometrium, Hyperplasia, Cystic, Glandular      3 (5%)                                 3 (5%)                                
   Vagina                                             (1)                                                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Lumen, Hemorrhage                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
      Erythrocyte, Atypia Cellular                     1 (50%)                                                                      
   Bone Marrow                                        (60)                                   (59)                                   
      Femoral, Myelofibrosis                           1 (2%)                                                                       
   Lymph Node, Mandibular                             (7)                                    (3)                                    
      Thrombosis                                       1 (14%)                                                                      
   Lymph Node, Mesenteric                             (5)                                    (3)                                    
      Angiectasis                                                                             2 (67%)                               
   Spleen                                             (60)                                   (60)                                   
      Fibrosis                                         1 (2%)                                 2 (3%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                 2 (3%)                                
   Thymus                                             (54)                                   (56)                                   
      Angiectasis                                                                             1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Depletion Lymphoid                               8 (15%)                                9 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)                                   (60)                                   
      Hyperplasia, Cystic                             58 (97%)                               56 (93%)                               
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                                    2 (3%)       1 (2%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
   Skin, Control                                                   (1)          (1)                                                 
      Acanthosis                                                    1 (100%)     1 (100%)                                           
      Sebaceous Gland, Hyperplasia                                  1 (100%)     1 (100%)                                           
   Skin, Site of Application-No Mass                  (2)          (3)          (8)          (39)                                   
      Acanthosis                                       2 (100%)     3 (100%)     8 (100%)    38 (97%)                               
      Erosion, Focal                                                                          1 (3%)                                
      Ulcer                                                         2 (67%)      4 (50%)     23 (59%)                               
      Sebaceous Gland, Hyperplasia                     1 (50%)      3 (100%)     7 (88%)     36 (92%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)                                   (60)                                   
      Femur, Hyperostosis                              2 (3%)                                 2 (3%)                                
      Femur, Osteopetrosis                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)                                   (60)                                   
      Compression                                     21 (35%)                               17 (28%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                    8 (13%)                                6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)                                   (60)                                   
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)                                
      Alveolar Epithelium, Hyperplasia                                                        1 (2%)                                
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
   Nose                                               (60)                                   (60)                                   
      Mucosa, Inflammation, Chronic Active             4 (7%)                                 5 (8%)                                
      Sinus, Foreign Body                              3 (5%)                                 5 (8%)                                
      Submucosa, Inflammation, Chronic                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)                                    (4)                                    
      Phthisis Bulbi                                   1 (17%)                                                                      
      Lens, Cataract                                   5 (83%)                                4 (100%)                              
      Retina, Atrophy                                  5 (83%)                                4 (100%)                              
   Harderian Gland                                    (1)                                    (1)                                    
      Inflammation, Chronic Active                     1 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Cyst                                             1 (2%)                                                                       
      Mineralization                                   8 (13%)                                9 (15%)                               
      Nephropathy, Chronic                            48 (80%)                               53 (88%)                               
   Urinary Bladder                                    (60)                                   (60)                                   
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8            8            5            4                                     
  Early Deaths                                                                                                                      
    Natural Death                                     12            7           11           15                                     
    Moribund Sacrifice                                25           34           34           25                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                15           11            8           16                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                                                                 (3)                                    
      Dysplasia                                                                               1 (33%)                               
      Ulcer                                                                                   1 (33%)                               
   Intestine Small, Jejunum                           (2)                                    (1)                                    
      Inflammation, Chronic                            1 (50%)                                                                      
   Liver                                              (60)                                   (60)                                   
      Basophilic Focus                                 6 (10%)                                7 (12%)                               
      Clear Cell Focus                                 3 (5%)                                 3 (5%)                                
      Eosinophilic Focus                               4 (7%)                                 3 (5%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       6 (10%)                                4 (7%)                                
      Inflammation, Chronic Active                     3 (5%)                                 3 (5%)                                
      Inflammation, Granulomatous                      2 (3%)                                 3 (5%)                                
      Bile Duct, Cyst                                                                         1 (2%)                                
      Bile Duct, Hyperplasia                          37 (62%)                               38 (63%)                               
      Hepatocyte, Degeneration, Cystic                 4 (7%)                                 9 (15%)                               
      Hepatocyte, Hyperplasia                                                                 1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic           22 (37%)                               21 (35%)                               
   Mesentery                                          (8)                                    (8)                                    
      Artery, Inflammation, Chronic Active             1 (13%)                                1 (13%)                               
      Fat, Hemorrhage                                  1 (13%)                                                                      
      Fat, Inflammation, Chronic Active                3 (38%)                                6 (75%)                               
   Pancreas                                           (60)                                   (60)                                   
      Acinus, Atrophy                                 23 (38%)                               26 (43%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                                 1 (2%)                                
   Stomach, Forestomach                               (10)                                   (13)                                   
      Acanthosis                                       4 (40%)                                2 (15%)                               
      Inflammation, Chronic Active                     1 (10%)                                2 (15%)                               
      Mineralization                                   1 (10%)                                2 (15%)                               
      Ulcer                                            5 (50%)                                8 (62%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (13)                                   (11)                                   
      Dysplasia                                        2 (15%)                                                                      
      Hyperplasia                                                                             1 (9%)                                
      Mineralization                                   5 (38%)                                3 (27%)                               
      Necrosis                                         1 (8%)                                 2 (18%)                               
      Pigmentation, Hemosiderin                        1 (8%)                                                                       
      Ulcer                                            4 (31%)                                5 (45%)                               
   Tongue                                             (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Tooth                                              (2)                                                                           
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Aorta, Mineralization                            1 (100%)                               1 (100%)                              
   Heart                                              (59)                                   (60)                                   
      Degeneration, Chronic                           51 (86%)                               50 (83%)                               
      Mineralization                                   1 (2%)                                 2 (3%)                                
      Atrium, Thrombosis                               6 (10%)                                4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (29)                                   (24)                                   
      Hyperplasia                                     13 (45%)                                6 (25%)                               
      Hypertrophy                                      2 (7%)                                                                       
      Vacuolization Cytoplasmic                       22 (76%)                               20 (83%)                               
   Adrenal Medulla                                    (27)                                   (29)                                   
      Hyperplasia                                     24 (89%)                               21 (72%)                               
   Islets, Pancreatic                                 (60)                                   (60)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (58)                                   (58)                                   
      Hyperplasia                                     37 (64%)                               39 (67%)                               
   Pituitary Gland                                    (60)                                   (60)                                   
      Pars Distalis, Cyst                              7 (12%)                                                                      
      Pars Distalis, Hemorrhage                                                               2 (3%)                                
      Pars Distalis, Hyperplasia                      13 (22%)                               11 (18%)                               
      Pars Distalis, Vacuolization Cytoplasmic                                                2 (3%)                                
   Thyroid Gland                                      (59)                                   (60)                                   
      Ultimobranchial Cyst                                                                    1 (2%)                                
      C-Cell, Hyperplasia                             12 (20%)                               11 (18%)                               
      Follicle, Cyst                                                                          1 (2%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)                                   (60)                                   
      Aspermia                                                                                2 (3%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
   Preputial Gland                                    (60)                                   (60)                                   
      Inflammation, Chronic Active                    46 (77%)                               38 (63%)                               
      Duct, Ectasia                                    1 (2%)                                 2 (3%)                                
   Prostate                                           (60)                                   (60)                                   
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic Active                    30 (50%)                               26 (43%)                               
      Inflammation, Granulomatous                                                             1 (2%)                                
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Seminal Vesicle                                    (60)                                   (60)                                   
      Atrophy                                                                                 1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 2 (3%)                                
      Mineralization                                   1 (2%)                                                                       
   Testes                                             (60)                                   (60)                                   
      Cyst                                                                                    1 (2%)                                
      Germinal Epithelium, Degeneration               16 (27%)                               17 (28%)                               
      Interstitial Cell, Hyperplasia                  17 (28%)                               13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)                                   (60)                                   
      Femoral, Myelofibrosis                           4 (7%)                                 4 (7%)                                
   Lymph Node                                         (8)                                    (14)                                   
      Mediastinal, Congestion                                                                 1 (7%)                                
      Mediastinal, Inflammation, Chronic Active                                               1 (7%)                                
      Pancreatic, Angiectasis                          1 (13%)                                                                      
   Lymph Node, Mandibular                             (13)                                   (17)                                   
      Hyperplasia, Lymphoid                            1 (8%)                                                                       
      Infiltration Cellular, Plasma Cell                                                      1 (6%)                                
   Lymph Node, Mesenteric                             (9)                                    (14)                                   
      Angiectasis                                      1 (11%)                                                                      
      Hyperplasia, Lymphoid                                                                   1 (7%)                                
      Inflammation, Chronic Active                                                            1 (7%)                                
   Spleen                                             (60)                                   (60)                                   
      Fibrosis                                        14 (23%)                                7 (12%)                               
      Infarct                                                                                 1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Capsule, Thrombosis                                                                     1 (2%)                                
   Thymus                                             (52)                                   (51)                                   
      Depletion Lymphoid                               9 (17%)                                7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)                                   (53)                                   
      Hyperplasia, Cystic                             50 (91%)                               49 (92%)                               
      Duct, Cyst                                                                              1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                       3 (5%)       2 (3%)                    1 (2%)                                
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Hyperkeratosis                                   1 (2%)                    1 (2%)       1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Skin, Control                                      (3)          (3)          (2)          (1)                                    
      Acanthosis                                       3 (100%)     3 (100%)     1 (50%)      1 (100%)                              
      Hyperplasia, Basal Cell                                                    1 (50%)                                            
      Dermis, Inflammation, Chronic                                 1 (33%)                                                         
   Skin, Site of Application-No Mass                  (2)          (1)          (8)          (16)                                   
      Acanthosis                                       1 (50%)                   6 (75%)     14 (88%)                               
      Acanthosis, Multifocal                                                     1 (13%)                                            
      Cyst                                                                                    1 (6%)                                
   Skin, Site of Application-Mass                     (5)                       (3)          (4)                                    
      Cyst Epithelial Inclusion                        1 (20%)                                2 (50%)                               
   Skin, Site of Application-No Mass                  (2)          (1)          (8)          (16)                                   
      Hyperkeratosis                                                                          2 (13%)                               
      Ulcer                                                                                   1 (6%)                                
   Skin, Site of Application-Mass                     (5)                       (3)          (4)                                    
      Dermis, Fibrosis                                 3 (60%)                                1 (25%)                               
      Dermis, Mineralization                           2 (40%)                                                                      
   Skin, Site of Application-No Mass                  (2)          (1)          (8)          (16)                                   
      Sebaceous Gland, Hyperplasia                                               4 (50%)      4 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)                                   (60)                                   
      Tarsal, Fracture                                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)                                   (60)                                   
      Compression                                     14 (23%)                               13 (22%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                   10 (17%)                                6 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05102-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:13:29  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0MG/KG      .15MG/KG     0.5MG/KG     1.5MG/KG                                  
                                                                                                                                    
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)                                   (60)                                   
      Inflammation, Chronic Active                     3 (5%)                                 2 (3%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                                 2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                                                                       
   Nose                                               (60)                                   (59)                                   
      Lumen, Hemorrhage                                                                       1 (2%)                                
      Mucosa, Inflammation, Chronic Active             6 (10%)                                6 (10%)                               
      Mucosa, Ulcer                                                                           1 (2%)                                
      Sinus, Foreign Body                              6 (10%)                                2 (3%)                                
      Submucosa, Inflammation, Acute                   1 (2%)                                                                       
   Trachea                                            (59)                                   (60)                                   
      Submucosa, Inflammation, Chronic                                                        1 (2%)                                
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                                    (3)                                    
      Lens, Cataract                                   2 (100%)                               2 (67%)                               
      Retina, Atrophy                                  2 (100%)                               2 (67%)                               
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)                                   (60)                                   
      Cyst                                                                                    1 (2%)                                
      Nephropathy, Chronic                            60 (100%)                              60 (100%)                              
      Cortex, Cyst                                     1 (2%)                                                                       
      Cortex, Renal Tubule, Mineralization             1 (2%)                                                                       
   Urinary Bladder                                    (60)                                   (60)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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