Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/1715

TDMS Study 05102-05 Pathology Tables

NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  121-54-0

       Lock Date:  01/24/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|             
                                           | 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                1         |             
      Basophilic Focus                     | X        X  X  X              X  X  X     X  X     X              X     X|             
      Clear Cell Focus                     |                                     X                                    |             
      Eosinophilic Focus                   |                                           X           X              X   |             
      Hepatodiaphragmatic Nodule           |          X  X           X              X  X                       X      |             
      Hepatodiaphragmatic Nodule, Multiple |                      X                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                   1                                                      |             
      Bile Duct, Hyperplasia               |    3  2           1                                         2            |             
      Hepatocyte, Necrosis                 |    2                                                                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                     2     2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                             +                                 |             
      Fat, Inflammation, Chronic Active    |          3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1     2  1  2     1        1                                   2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                          +                                          |             
      Ulcer                                |    3                          3                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 1  2  2  1  2           1        1        1  2              2  1     1   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +     +  +                          +        +              +   |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |       2           2                          2        2              2   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 3        2     2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +        +                                                         |             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2     3  3  3        3     2                             2  2     2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|             
                                           | 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |             X              X           X           X                 X  X|             
      Pars Distalis, Hyperplasia           | 3           2                          2     2     2        3        2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  2     2           2        2  2        2           2  1        2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4                                                                     |             
      Inflammation, Chronic Active         |                                              2           3               |             
      Duct, Cyst                           |                                                          X               |             
      Duct, Ectasia                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |    X                                                        X            |             
      Periovarian Tissue, Cyst             | X                    X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Erythrocyte, Atypia Cellular         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +                                                     +            |             
      Thrombosis                           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                      2     2           2                 2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  3  2     3  3  2  3     3  3  2  2  2  3  2  2  3  2  2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                          |             
      Acanthosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 4| 6| 4| 5| 7| 7| 4| 7| 7| 1| 7| 6| 4| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 7| 5| 9| 5| 1| 3| 2| 5| 3| 3| 7| 3| 4| 5| 1| 4| 4| 3| 3|             
                                           | 1| 4| 8| 1| 1| 1| 2| 6| 6| 6| 9| 1| 4| 6| 1| 1| 6| 1| 9| 6| 0| 4| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    2  2  2        2     3     2  2  3     3                              |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                         2     2  2  2                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
      Perivascular, Inflammation, Chronic  |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |             3                                                        1   |             
      Sinus, Foreign Body                  |             2                                                            |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                       +     +|             
      Phthisis Bulbi                       |                                                                          |             
      Lens, Cataract                       |                                           4                       3     4|             
      Retina, Atrophy                      |                                           4                       4     4|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
      Inflammation, Chronic Active         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                      2     2                    2                        |             
      Nephropathy, Chronic                 | 2  4  3  3  2  2  2     3     2  2  3     3  3     3  2  1     1     3  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|             
                                           | 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                       +                  |             
      Ulcer                                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         3|             
      Basophilic Focus                     |       X  X        X              X  X     X              X  X  X        X|             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                X                 X  X     X        X           X        X|             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Inflammation, Granulomatous          |          2        2              2     2                             2  2|             
      Bile Duct, Hyperplasia               |       2     1           2     1                       2                  |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                2           4        4                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +        +                                          |             
      Fat, Inflammation, Chronic Active    |                      3        2                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2           1           1  1                          2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +        +                                    |             
      Ulcer                                |                            3        3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +                                             |             
      Necrosis                             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 1     1     2  1                 1  1           1        2  1  1        1|             
      Atrium, Thrombosis                   |                      X                                X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |             +  +           +                    +     +                  |             
      Degeneration, Cystic                 |                                                 2                        |             
      Hyperplasia                          |                                                 2                        |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |             2  4           2                          4                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |             +                                   +     +  +  +        +  +|             
      Hyperplasia                          |             2                                         2     2        2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3  2  2  3  2  3  1  2     2  3  2  3     1     2  2  2  3        2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|             
                                           | 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  | X                       X     X                                      X   |             
      Pars Distalis, Hyperplasia           |    3  2     2        3  3     2                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2     1  2                 3  2           2        3  2  2        2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2              3        2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                           X              X               |             
      Periovarian Tissue, Cyst             |          X     X                                         X        X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                              2        4                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
      Lumen, Hemorrhage                    |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Erythrocyte, Atypia Cellular         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  +                          +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +              +                                             |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +              +                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +|             
      Depletion Lymphoid                   | 2  2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  2  2  3  3  3  3  3  3  2  2  3  2  2  2  4  3  2  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                    +                     |             
      Acanthosis                           |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 3| 3| 5| 2| 3| 8| 9| 3| 3| 4| 3| 2| 3| 6| 1| 3| 3| 3| 5| 3| 3|             
                                           | 6| 6| 1| 1| 3| 1| 4| 0| 1| 5| 5| 1| 1| 5| 1| 6| 1| 7| 9| 1| 1| 1| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          2        2                 3  3  2        2           2         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                     3     2                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |             3                             3                              |             
      Sinus, Foreign Body                  |             3                             2                              |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +     +                                         +            |             
      Phthisis Bulbi                       |             X                                                            |             
      Lens, Cataract                       |                   4                                         4            |             
      Retina, Atrophy                      |                   4                                         4            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Mineralization                       | 3  2                                                              3      |             
      Nephropathy, Chronic                 | 1     4  3  2  3  2  3  1        1  2  3  2     1  2  2  2  3  3     2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 7| 6| 5| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1|                                            |            |
                                           | 8| 6| 1| 3| 2| 2| 5| 6| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                                               |   2        |
      Ulcer                                |          2                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |       X     X  X  X                                                      |     26     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |       X     X           X                                                |     13     |
      Hepatodiaphragmatic Nodule           |             X        X                                                   |      9     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Inflammation, Chronic Active         |                      2                                                   |      2  2.0|
      Inflammation, Granulomatous          |                   2                                                      |      8  1.9|
      Bile Duct, Hyperplasia               |                   1        2                                             |     11  1.7|
      Hepatocyte, Necrosis                 |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|          4                 3                                             |      7  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Inflammation, Chronic Active    |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |          2     1           1                                             |     15  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +                                                               |   6        |
      Ulcer                                | 3        3                                                               |      6  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Chronic                | 2     1     1  2  1     2                                                |     29  1.3|
      Atrium, Thrombosis                   |          X                                                               |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +  +           +  +                                             |  19        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |             2                                                            |      7  2.0|
      Necrosis                             |          3                 3                                             |      2  3.0|
      Vacuolization Cytoplasmic            |                         2                                                |      8  2.6|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                            +                                             |  10        |
      Hyperplasia                          |                                                                          |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 7| 6| 5| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1|                                            |            |
                                           | 8| 6| 1| 3| 2| 2| 5| 6| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M                                             |  56        |
      Hyperplasia                          |       3  3  3                                                            |     32  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Necrosis                             |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                      X                                                   |     11     |
      Pars Distalis, Hyperplasia           |                      2     2                                             |     17  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |       2  2                 2                                             |     24  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +                                             |  59        |
      Hyperplasia                          |                   2                                                      |      5  2.6|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicle, Cyst                       |                                                                          |      4     |
      Periovarian Tissue, Cyst             |    X     X                                                               |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Lumen, Hemorrhage                    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |          +              +                                                |   2        |
      Erythrocyte, Atypia Cellular         |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femoral, Myelofibrosis               |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                          +                                             |   7        |
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                          +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 7| 6| 5| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1|                                            |            |
                                           | 8| 6| 1| 3| 2| 2| 5| 6| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +                                             |  54        |
      Depletion Lymphoid                   |    2                 2                                                   |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  | 3  3  3  3  3  3  3  2  3  2                                             |     58  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                         +                                                |   2        |
      Acanthosis                           |                         1                                                |      2  2.0|
      Sebaceous Gland, Hyperplasia         |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |       2     3  3  3     2                                                |     21  2.4|
      Hemorrhage                           |             2                                                            |      1  2.0|
      Hydrocephalus                        |       2     3                                                            |      8  2.3|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |             2                                                            |      2  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Inflammation, Chronic Active |                                                                          |      4  2.5|
      Sinus, Foreign Body                  |                                                                          |      3  2.3|
      Submucosa, Inflammation, Chronic     |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
      Phthisis Bulbi                       |                                                                          |      1     |
      Lens, Cataract                       |                                                                          |      5  3.8|
      Retina, Atrophy                      |                                                                          |      5  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 6| 7| 6| 5| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 5| 3| 0| 2| 4| 1| 5| 0| 1|                                            |            |
                                           | 8| 6| 1| 3| 2| 2| 5| 6| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Mineralization                       |    2                 3                                                   |      8  2.4|
      Nephropathy, Chronic                 | 2  1  3  1  3  3  1     2  1                                             |     48  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 0| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3|             
                                           | 0| 1| 2| 6| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 9| 6| 0| 0| 6| 8| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .15                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
      Acanthosis                           |                                                                          |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |             +                                                        +   |             
      Acanthosis                           |             3                                                        4   |             
      Ulcer                                |             3                                                            |             
      Sebaceous Gland, Hyperplasia         |             3                                                        2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 4| 7| 7| 7| 3| 7| 7| 4| 7| 3| 6| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 9| 3| 3| 5| 3| 6| 1| 3| 3| 8| 8| 3| 5| 1| 3| 3| 5| 7| 5|             
                                           | 8| 0| 6| 0| 0| 0| 3| 0| 0| 6| 0| 6| 2| 3| 0| 0| 2| 0| 6| 2| 0| 1| 6| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .15                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                             +            |             
      Acanthosis                           |                                                             2            |             
      Sebaceous Gland, Hyperplasia         |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |       +                                                                  |             
      Acanthosis                           |       3                                                                  |             
      Ulcer                                |       2                                                                  |             
      Sebaceous Gland, Hyperplasia         |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 3| 3| 3| 1|                                            |            |
                                           | 1| 1| 7| 1| 4| 1| 1| 1| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .15                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |          4                                                               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   1        |
      Acanthosis                           |                                                                          |      1  2.0|
      Sebaceous Gland, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   3        |
      Acanthosis                           |                                                                          |      3  3.3|
      Ulcer                                |                                                                          |      2  2.5|
      Sebaceous Gland, Hyperplasia         |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 3| 3| 3| 1|                                            |            |
                                           | 1| 1| 7| 1| 4| 1| 1| 1| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .15                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 5| 7| 4| 6| 4| 5| 4| 6| 4| 7| 6| 2| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 4| 2| 2| 7| 2| 5| 8| 5| 3| 5| 7| 5| 2| 3| 9| 0| 1| 2| 2| 2| 3| 0| 1| 3|             
                                           | 9| 9| 9| 9| 9| 9| 6| 6| 6| 3| 6| 8| 6| 9| 2| 7| 8| 0| 9| 9| 9| 0| 6| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             3                                                            |             
      Hyperkeratosis                       |             4                                                            |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
      Acanthosis                           |                                                                          |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |       +                 +        +              +                        |             
      Acanthosis                           |       3                 1        2              3                        |             
      Ulcer                                |       3                                         3                        |             
      Sebaceous Gland, Hyperplasia         |       2                          1              2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 5| 7| 4| 6| 4| 5| 4| 6| 4| 7| 6| 2| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 4| 2| 2| 7| 2| 5| 8| 5| 3| 5| 7| 5| 2| 3| 9| 0| 1| 2| 2| 2| 3| 0| 1| 3|             
                                           | 9| 9| 9| 9| 9| 9| 6| 6| 6| 3| 6| 8| 6| 9| 2| 7| 8| 0| 9| 9| 9| 0| 6| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 4| 4| 6| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 5| 5| 8| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 9| 6| 8| 3| 3| 3| 7| 2| 0|             
                                           | 0| 6| 6| 6| 1| 0| 0| 0| 0| 0| 8| 0| 0| 4| 8| 0| 2| 5| 5| 0| 0| 0| 9| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                +         |             
      Acanthosis                           |                                                                2         |             
      Sebaceous Gland, Hyperplasia         |                                                                2         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +                                         +           +               |             
      Acanthosis                           |    3                                         3           4               |             
      Ulcer                                |    2                                                     4               |             
      Sebaceous Gland, Hyperplasia         |    2                                         2           2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 4| 4| 6| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 5| 5| 8| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 9| 6| 8| 3| 3| 3| 7| 2| 0|             
                                           | 0| 6| 6| 6| 1| 0| 0| 0| 0| 0| 8| 0| 0| 4| 8| 0| 2| 5| 5| 0| 0| 0| 9| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 4| 7| 7| 6| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3|                                            |            |
                                           | 5| 0| 6| 0| 0| 8| 5| 6| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.5                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   1        |
      Acanthosis                           |                                                                          |      1  2.0|
      Sebaceous Gland, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                            +                                             |   8        |
      Acanthosis                           |                            3                                             |      8  2.8|
      Ulcer                                |                                                                          |      4  3.0|
      Sebaceous Gland, Hyperplasia         |                            1                                             |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 4| 7| 7| 6| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 5| 3| 3| 6| 2| 5| 3| 3|                                            |            |
                                           | 5| 0| 6| 0| 0| 8| 5| 6| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.5                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|             
                                           | 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X        X     X     X        X  X              X  X  X   |             
      Clear Cell Focus                     | X        X                    X              X                           |             
      Eosinophilic Focus                   |                         X                             X  X     X         |             
      Hepatodiaphragmatic Nodule           |                   X     X        X                 X  X     X  X  X      |             
      Inflammation, Chronic Active         |                            2     2                                       |             
      Inflammation, Granulomatous          |             2                                      2  2              2   |             
      Bile Duct, Hyperplasia               | 2                    3              2     3                 2     2      |             
      Hepatocyte, Degeneration, Cystic     |                                                                          |             
      Hepatocyte, Hypertrophy, Focal       |                      3                                                   |             
      Hepatocyte, Vacuolization Cytoplasmic|                         2                 2     2     2        2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Inflammation, Chronic Active    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      | 2           2  2           2  1                 1              2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +                                +     +            |             
      Acanthosis                           |                                                       3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                      3                                      2            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Cyst                                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |    1  2  1  1  1        1        1  1  1     1  1  1  1        1  2  1  1|             
      Atrium, Thrombosis                   |                      X                    X                 X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +     +  +                 +                 +  +         |             
      Degeneration, Cystic                 |                                                             3            |             
      Hyperplasia                          | 2  2     2  2           2                                      2         |             
      Hypertrophy                          |                2                                                         |             
      Necrosis                             |                                           3                              |             
      Vacuolization Cytoplasmic            |             2        2                                         2         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                                           +                              |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
      Hyperplasia                          |    3  3        3     4        2     3     3  3  3     3  2     3  2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|             
                                           | 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                                                                          |             
      Pars Distalis, Cyst                  | X                 X           X           X     X           X            |             
      Pars Distalis, Hyperplasia           | 4        3                    2  3  2           3  2     2  2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Ultimobranchial Cyst      |                                                                          |             
      C-Cell, Hyperplasia                  | 3        2  2  2        2     2     2     2  2  3                        |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2        4                                                     2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Ectasia                        |                                           3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                     X                       X            |             
      Periovarian Tissue, Cyst             | X  X        X  X              X        X  X     X        X              X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +     +                                   +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                         +|             
      Angiectasis                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      3                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                   2        2           2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  2  2  3  2  2  3  3  3     3  3  2     4  3  3  3  4  2  2  3  3  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +     +  +  +  +  +  +  +  +     +     +  +  +     +     +  +  +   |             
      Acanthosis                           | 3  2  4     3  3  3  3  3  2  3  2     3     3  3  3     3     3  1  3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7| 4| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 2| 2| 5| 8| 2| 5| 2| 5| 2| 5| 3| 2| 2| 2| 4| 8| 4| 2| 9| 2| 2|             
                                           | 9| 8| 9| 9| 9| 9| 6| 7| 9| 6| 9| 6| 9| 6| 4| 9| 9| 9| 7| 0| 0| 9| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Erosion, Focal                       |                            2                                             |             
      Ulcer                                | 2     3     1  2              1  2     3     2  2  2                 2   |             
      Sebaceous Gland, Hyperplasia         | 2  2  2     2  2  2     2  2  2  2     2     2  2  2     2     2     2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                               X                                X         |             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 2  2     2                                   3        2        2  2  2   |             
      Hydrocephalus                        |                                                                2     2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                    +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                    +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |                                     3              2                     |             
      Sinus, Foreign Body                  |                                     2              2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                                         +      |             
      Lens, Cataract                       |                      3  4                                         3      |             
      Retina, Atrophy                      |                      4  4                                         4      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Inflammation, Chronic Active         |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   3        2     2     1                                 |             
      Nephropathy, Chronic                 | 2  2  3  2  3  1     1  1  1  2  2  2  1  2  3  3  2  2  2     4  3  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|             
                                           | 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X  X     X  X  X     X     X     X  X  X        X  X  X     X|             
      Clear Cell Focus                     |                                                             X  X         |             
      Eosinophilic Focus                   |       X                    X           X     X              X  X         |             
      Hepatodiaphragmatic Nodule           |          X  X                             X        X  X     X            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |    2           2     2                             2           2         |             
      Bile Duct, Hyperplasia               | 2     2                       2                 1        3              2|             
      Hepatocyte, Degeneration, Cystic     |                         2                                   2            |             
      Hepatocyte, Hypertrophy, Focal       |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                2     2                                   3               |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                  +  +            |             
      Fat, Inflammation, Chronic Active    |       3                                                  4  3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          4               |             
      Acinus, Atrophy                      |                2     2     2                       2     2        1     2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +                                         +        +  +   |             
      Acanthosis                           |                3                                         3               |             
      Inflammation, Chronic Active         |                3                                                         |             
      Mineralization                       |                                                                      2   |             
      Ulcer                                | 2              3                                                  3      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |    2  1     1           2  1           1           1  2     1  1        2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +              +  +  +                    +  +     +  +           +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |       2              2     2                       2                    2|             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                         3                                                |             
      Vacuolization Cytoplasmic            |                            2                    2        3  2           2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |                         +                                                |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2     2  3        4     2  2              3  2  2  3  3  2     2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|             
                                           | 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                                                                          |             
      Pars Distalis, Cyst                  | X                                      X        X           X            |             
      Pars Distalis, Hyperplasia           |       3  2              4              3     3              2  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Ultimobranchial Cyst      |          X                                                               |             
      C-Cell, Hyperplasia                  |                                        2        2                       2|             
      Follicular Cell, Hyperplasia         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Ectasia                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                   X              X                    X                 X|             
      Periovarian Tissue, Cyst             |                                     X                          X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                      2              3  2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +                                          |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          3               |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                X         |             
      Depletion Lymphoid                   |          2        2                 2     2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  3  2  3  3  2  2  3  3  3  2  3  3  3  2  2  1  3  2  3  3  2  2  3  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +     +     +  +           +  +        +  +     +  +  +     +     +  +|             
      Acanthosis                           |    2     3     2  2           3  1           3     3  3  2     2     2  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 4| 6| 6| 3| 7| 7| 7| 6| 4| 4| 7| 3| 5| 5| 6| 5| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 8| 1| 2| 5| 6| 3| 0| 2| 2| 2| 5| 8| 5| 2| 2| 9| 3| 3| 3| 2| 2| 2| 7| 3| 2|             
                                           | 7| 9| 9| 6| 7| 2| 3| 9| 9| 9| 8| 6| 6| 9| 2| 4| 3| 4| 7| 3| 9| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Erosion, Focal                       |                                                                          |             
      Ulcer                                |    2     2                    2              2     1  2              1  2|             
      Sebaceous Gland, Hyperplasia         |    2     2     2  1           2  2        1  2     2  2  2           2  2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    2        2  3           2                       3     2        2      |             
      Hydrocephalus                        |                2           2                       2              2      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +              +                                                         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +              +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |                                                 2  2                     |             
      Sinus, Foreign Body                  |                                                 1  2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Lens, Cataract                       |                                                    3                     |             
      Retina, Atrophy                      |                                                    4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2        2                 2     1                              |             
      Nephropathy, Chronic                 | 2  2  1  1  2  4     3  4  2  2  2     1     1     2  2  4  2  1  1  2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5|                                            |            |
                                           | 9| 3| 7| 0| 9| 9| 3| 6| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     | X        X  X  X                                                         |     33     |
      Clear Cell Focus                     |       X                                                                  |      7     |
      Eosinophilic Focus                   | X  X        X                                                            |     13     |
      Hepatodiaphragmatic Nodule           |    X           X  X        X                                             |     18     |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Inflammation, Granulomatous          |                2  1                                                      |     11  1.9|
      Bile Duct, Hyperplasia               |       1                                                                  |     13  2.1|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      2  2.0|
      Hepatocyte, Hypertrophy, Focal       |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      8  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Inflammation, Chronic Active    |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Acinus, Atrophy                      | 1              1     1                                                   |     17  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   8        |
      Acanthosis                           |                                                                          |      3  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Chronic                |       2  1           1  1  1                                             |     33  1.2|
      Atrium, Thrombosis                   |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +                                                            |  21        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hyperplasia                          |             2                                                            |     12  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  3.0|
      Vacuolization Cytoplasmic            |             2                                                            |      9  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5|                                            |            |
                                           | 9| 3| 7| 0| 9| 9| 3| 6| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Hyperplasia                          |    2  2           2                                                      |     32  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |            |
           Cyst                            |                      X                                                   |      1     |
      Pars Distalis, Cyst                  | X              X                                                         |     12     |
      Pars Distalis, Hyperplasia           |       3     2  2     3                                                   |     20  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Ultimobranchial Cyst      |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 2        2  2  2                                                         |     17  2.1|
      Follicular Cell, Hyperplasia         |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      4  2.5|
      Inflammation, Chronic Active         |          4                                                               |      1  4.0|
      Duct, Ectasia                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicle, Cyst                       |                            X                                             |      7     |
      Periovarian Tissue, Cyst             |                      X                                                   |     13     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  M  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   3        |
      Angiectasis                          |                   3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5|                                            |            |
                                           | 9| 3| 7| 0| 9| 9| 3| 6| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                      2                                                   |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Depletion Lymphoid                   |                      X     3                                             |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  | 3  2  2  3  3  3  2  3  2                                                |     56  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |    +     +     +  +  +  +                                                |  39        |
      Acanthosis                           |    3     3     3  2  3  3                                                |     38  2.7|
      Erosion, Focal                       |                                                                          |      1  2.0|
      Ulcer                                |    2     2           2  1                                                |     23  1.9|
      Sebaceous Gland, Hyperplasia         |    2     2     1  1  2  2                                                |     36  1.9|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                                                                          |      2     |
      Femur, Osteopetrosis                 |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |          2              3                                                |     17  2.2|
      Hydrocephalus                        |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 1              1                                                         |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Inflammation, Chronic Active |                            3                                             |      5  2.4|
      Sinus, Foreign Body                  |                            3                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Lens, Cataract                       |                                                                          |      4  3.3|
      Retina, Atrophy                      |                                                                          |      4  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 0| 7| 0| 2| 2| 1| 5| 6| 5|                                            |            |
                                           | 9| 3| 7| 0| 9| 9| 3| 6| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |                      2                                                   |      9  1.9|
      Nephropathy, Chronic                 | 2  3  1  3  4  1  2  1  1                                                |     53  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                        X                                 |             
      Clear Cell Focus                     |                      X                                                   |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                       X                 X  X         |             
      Inflammation, Chronic Active         |       1                                                                  |             
      Inflammation, Granulomatous          |                                              2                           |             
      Bile Duct, Hyperplasia               | 2  1        4     2  2     2  3        2        2  2  2  3  2     3     2|             
      Hepatocyte, Degeneration, Cystic     |                                                 2                        |             
      Hepatocyte, Vacuolization Cytoplasmic| 1                 2  2     4     3           2  2           2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +           +                       +  +                  |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Hemorrhage                      |                                                    2                     |             
      Fat, Inflammation, Chronic Active    |                            3                          2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1        1        2           3           1        1  2     2  2  2     2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                 +              +  +              +     +   |             
      Acanthosis                           |                                              3  3              3         |             
      Inflammation, Chronic Active         |                                              3                           |             
      Mineralization                       |                                                                          |             
      Ulcer                                |             3                 2                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                                      +              +     +|             
      Dysplasia                            |                                                                          |             
      Mineralization                       |                                                                         3|             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                    1                     |             
      Ulcer                                |             2                                                     3      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
      Inflammation, Chronic Active         |                               3                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 3  1  2     2     2  2  2  3  2  2  1  1  2     3  2  1     1     3  1  2|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |    X        X                                         X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +                 +     +        +  +  +     +  +  +     +     +  +     +|             
      Hyperplasia                          | 2                 2                          2  2                       2|             
      Hypertrophy                          |                                  1                                       |             
      Vacuolization Cytoplasmic            | 1                       1        1  2  2     2  2  2     2     2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +        +        +  +  +     +           +     +     +              +|             
      Hyperplasia                          |    1        2        2  2  2                 2     2     2              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3     2  3        3  3  3     2  2  3     3  4  2  2  2     4        4|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                          X  X            |             
      Pars Distalis, Hyperplasia           |                2        3     3        3                 2              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2                          2        2                 2               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2     2  2        2     3  2  2     2  2  2     2  2  2  1  2  3  2  2|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2     2  3              3        2     1     2     2  2  2  2  3  1   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   2      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |             2              3                 2  3     3  3     2        3|             
      Interstitial Cell, Hyperplasia       | 2     2        2  2                       2                 2        2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +                                   +        +            |             
      Pancreatic, Angiectasis              |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                    +     +        +           +     +               |             
      Hyperplasia, Lymphoid                |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +                    +                             +               |             
      Angiectasis                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 3                 2     3  3        2                    3        2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |       3           3                       3                 3        3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  2        1  2  2     1  2     1  2  3     3  3  2  3        3  1     1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        3                                 |             
      Hyperkeratosis                       |                4                                                         |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                   +      |             
      Acanthosis                           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                +                                                         |             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                            +                                             |             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Dermis, Fibrosis                     |                                                                          |             
      Dermis, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                +                                                         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 3        2                       2  2  2     2        3                  |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |          2                       2  2        2        2                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |             +                                +                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                             2                     |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 6| 5| 4| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 5| 6| 6| 4| 6| 7| 4| 7|             
                             DAY ON TEST   | 2| 5| 5| 3| 0| 1| 5| 3| 0| 3| 5| 3| 0| 3| 5| 0| 3| 5| 4| 5| 5| 9| 3| 5| 3|             
                                           | 6| 0| 6| 3| 3| 3| 6| 1| 6| 1| 3| 1| 6| 1| 6| 6| 1| 6| 7| 5| 6| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                             2            |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |                                     3  3                                 |             
      Sinus, Foreign Body                  |                                     3  2                                 |             
      Submucosa, Inflammation, Acute       |                                           2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Lens, Cataract                       |                            3                                             |             
      Retina, Atrophy                      |                            3                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  3  2  3  4  3  3  4  3  4  4  4  4  4  2  4  4  3  4  4  3  4  4  2  4|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Renal Tubule, Mineralization |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
      Inflammation, Chronic                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                       X  X                       X  X                  |             
      Clear Cell Focus                     |                                                       X                  |             
      Eosinophilic Focus                   |                            X                       X                 X  X|             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Hepatodiaphragmatic Nodule           |    X                                                                    X|             
      Inflammation, Chronic Active         |          1                             2                                 |             
      Inflammation, Granulomatous          |    2                                                                     |             
      Bile Duct, Hyperplasia               |             2  1     2        3     2     2  4  1  1  2  2           2  3|             
      Hepatocyte, Degeneration, Cystic     |                            2  2                                2         |             
      Hepatocyte, Vacuolization Cytoplasmic|    2  2  2     1        2  1        3  3                 2  2  4  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                +         |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Inflammation, Chronic Active    |                               2                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          2              2     3     3        1  2           2     2     2|             
      Artery, Inflammation, Chronic Active |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +                                +                    +               |             
      Acanthosis                           | 3                                                                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    2                                                                     |             
      Ulcer                                |                                     2                    3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +           +     +           +           +     +         |             
      Dysplasia                            |       2                    2                                             |             
      Mineralization                       |    3                             2                       1     3         |             
      Necrosis                             |                                              2                           |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                3                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
      Aorta, Mineralization                |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Degeneration, Chronic                | 3  3     1  3  2     2  1  2  1  3  2  2  2  2  2  2  2  2     2  2     2|             
      Mineralization                       |    3                                                                     |             
      Atrium, Thrombosis                   |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +     +           +  +  +  +  +           +              +  +     +|             
      Hyperplasia                          |    2        2           2     2     2                          2  2      |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |       3     2           2  1     1  2           2              1        1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +        +     +  +  +     +  +           +        +           +  +|             
      Hyperplasia                          |       2        2        2  2     2  2           2        2           1  3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Hyperplasia                          | 3  4  3     3  4     2  4  3     3  3        2  3     3  4     4        3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                               X           X         |             
      Pars Distalis, Hyperplasia           |    2                 3        2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      C-Cell, Hyperplasia                  |                            2  2     2        2        2                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 4  2     2  2  2  2  2     2     2  2     1  2  2  1  2  3     2  2  2  2|             
      Duct, Ectasia                        |                                                                      3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2              2  1  2     2  2     2     1     2     2            |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    3                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                2     3           3  3     3              3     3        2|             
      Interstitial Cell, Hyperplasia       |          2  2           2     2        2     2              2           2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |    4                                                     3     3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +              +                          +|             
      Pancreatic, Angiectasis              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +                                   +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +                                      +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2                 2                          1     2  3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Depletion Lymphoid                   |          3        3                    3                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2     3  3  3  3  3  3  1  2  3  2  3  1  2  2  3  3  2  3  3  2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     3                                    |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +                                +                                       |             
      Acanthosis                           | 3                                1                                       |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                         +|             
      Acanthosis                           |                                                                         1|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Dermis, Fibrosis                     |                                                                          |             
      Dermis, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                         +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       2           3                 3     2                       2      |             
      Hemorrhage                           |                   3                                                      |             
      Hydrocephalus                        |       2                          2  2                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                       +                          +               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                       +                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic Active         |    2                                                                     |             
      Inflammation, Suppurative            |                                                          2               |             
      Mineralization                       |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 4| 7| 6| 4| 7| 6| 7| 5| 6| 7| 4| 7| 5| 7| 7| 7| 6| 4| 7| 6| 5| 6|             
                             DAY ON TEST   | 7| 0| 5| 5| 3| 5| 0| 3| 3| 3| 9| 8| 1| 5| 1| 4| 3| 3| 3| 9| 3| 0| 3| 5| 1|             
                                           | 9| 9| 9| 6| 1| 3| 6| 1| 2| 1| 2| 9| 6| 6| 4| 9| 1| 1| 1| 1| 7| 9| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |                      3        3                 2                    2   |             
      Sinus, Foreign Body                  |                      3        2                 2                    2   |             
      Submucosa, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +        +                     |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Lens, Cataract                       | 3                                                                        |             
      Retina, Atrophy                      | 4                                                                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  4  4  2  4  4  2  4  4  4  4  4  4  2  4  3  4  4  4  4  2  4  4  4  3|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Renal Tubule, Mineralization |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2                                                                  |             
      Transitional Epithelium, Hyperplasia |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      6     |
      Clear Cell Focus                     | X                                                                        |      3     |
      Eosinophilic Focus                   |                                                                          |      4     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |    2  3  3  2  1  2  1  2  2                                             |     37  2.1|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      4  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                   2  2                                                   |     22  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +                                                   |   8        |
      Artery, Inflammation, Chronic Active |    4                                                                     |      1  4.0|
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |    2        2     3                                                      |     23  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  10        |
      Acanthosis                           |                                                                          |      4  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                         +                                                |  13        |
      Dysplasia                            |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      5  2.4|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Ulcer                                |                         2                                                |      4  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   2        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active                  |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Degeneration, Chronic                | 2  1  2  1  2  1  2  2  2  1                                             |     51  1.9|
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |       X                 X                                                |      6     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +        +        +                                                |  29        |
      Hyperplasia                          | 2                                                                        |     13  2.0|
      Hypertrophy                          |                         2                                                |      2  1.5|
      Vacuolization Cytoplasmic            |       2        3                                                         |     22  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +     +  +        +  +                                             |  27        |
      Hyperplasia                          | 2     2        2        2  2                                             |     24  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          | 3     3     2              3                                             |     37  2.9|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Cyst                  |                X           X                                             |      7     |
      Pars Distalis, Hyperplasia           | 3     3        3           2                                             |     13  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Hyperplasia                  | 2     2                 2                                                |     12  2.0|
      Follicular Cell, Hyperplasia         |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 2     3  2  1  2  2     2                                                |     46  2.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 1        2        2  4  4  2                                             |     30  2.1|
      Epithelium, Hyperplasia              |                            2                                             |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Germinal Epithelium, Degeneration    |                                                                          |     16  2.7|
      Interstitial Cell, Hyperplasia       |       2           2                                                      |     17  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Femoral, Myelofibrosis               |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   8        |
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +              +                                                |  13        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +              +                                                |   9        |
      Angiectasis                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             | 1  2                                                                     |     14  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Depletion Lymphoid                   |                   2                                                      |      9  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +                                             |  55        |
      Hyperplasia, Cystic                  | 3  4  1  2  1  1  2  3     2                                             |     50  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                         3                                                |      3  3.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   3        |
      Acanthosis                           |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   2        |
      Acanthosis                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |    +  +        +                                                         |   5        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Dermis, Fibrosis                     |    2  4        3                                                         |      3  3.0|
      Dermis, Mineralization               |    2  2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |    +  +        +                                                         |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 5| 4| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 4| 8| 5| 4| 1| 6|                                            |            |
                                           | 1| 1| 4| 5| 8| 3| 6| 7| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |          2           4                                                   |     14  2.4|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |          2           2                                                   |     10  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Inflammation, Chronic Active |                                                                          |      6  2.7|
      Sinus, Foreign Body                  |                                                                          |      6  2.3|
      Submucosa, Inflammation, Acute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      2  3.0|
      Retina, Atrophy                      |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy, Chronic                 | 4  4  4  3  3  3  2  4  4  3                                             |     60  3.5|
      Cortex, Cyst                         |                   X                                                      |      1     |
      Cortex, Renal Tubule, Mineralization |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 7| 3| 5| 2| 7| 6| 4| 7| 7| 6| 4| 6| 4| 6| 6| 4| 6| 7| 5| 6| 5| 4|             
                             DAY ON TEST   | 6| 6| 7| 3| 7| 4| 6| 1| 9| 5| 3| 3| 9| 5| 3| 5| 1| 3| 5| 3| 3| 9| 7| 4| 5|             
                                           | 4| 1| 9| 0| 9| 1| 4| 0| 1| 7| 0| 0| 8| 6| 8| 6| 2| 2| 6| 9| 0| 1| 0| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    .15                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            4                                4            |             
                                            __________________________________________________________________________|             
   Skin, Control                           |          +                                                  +            |             
      Acanthosis                           |          2                                                  1            |             
      Dermis, Inflammation, Chronic        |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 6| 6| 5| 4| 4| 5| 7| 5| 6| 7| 6| 4| 7| 6| 7| 6| 7| 6| 7| 6| 5| 6|             
                             DAY ON TEST   | 2| 5| 7| 7| 2| 9| 5| 9| 7| 2| 7| 0| 3| 6| 5| 3| 9| 3| 7| 3| 5| 3| 5| 5| 2|             
                                           | 3| 6| 9| 5| 6| 3| 6| 9| 8| 2| 6| 6| 0| 8| 6| 0| 8| 1| 1| 1| 9| 1| 9| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .15                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                          +               |             
      Acanthosis                           |                                                          2               |             
      Dermis, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 6| 7| 5| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2|                                            |            |
                                           | 1| 1| 1| 2| 0| 2| 6| 6| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    .15                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           |                                                                          |   3        |
      Acanthosis                           |                                                                          |      3  1.7|
      Dermis, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 6| 7| 5| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 1| 1| 1| 5| 1| 5| 2|                                            |            |
                                           | 1| 1| 1| 2| 0| 2| 6| 6| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    .15                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|             
                             DAY ON TEST   | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|             
                                           | 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |             +  +                       +              +        +         |             
      Acanthosis                           |             1  1                       1              1                  |             
      Acanthosis, Multifocal               |                                                                1         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                             +            |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |             +  +                       +              +        +         |             
      Sebaceous Gland, Hyperplasia         |                                                       2        2         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 7| 6| 4| 6| 7| 5| 5| 6| 4| 4| 6| 7| 6| 6| 5| 3| 7| 4| 6| 6| 4|             
                             DAY ON TEST   | 5| 0| 6| 8| 0| 4| 1| 7| 2| 2| 9| 6| 3| 5| 4| 1| 3| 9| 1| 6| 2| 5| 5| 4| 8|             
                                           | 6| 0| 4| 2| 7| 3| 6| 6| 9| 3| 9| 6| 7| 6| 8| 8| 2| 6| 1| 7| 9| 6| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|             
                                           | 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                       +                  |             
      Acanthosis                           |                                                       2                  |             
      Hyperplasia, Basal Cell              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +                                                                     |             
      Acanthosis                           |                                                                          |             
      Acanthosis, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +                                                                     |             
      Sebaceous Gland, Hyperplasia         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6| 0| 5| 7| 5| 6| 1| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 5| 8| 2| 2| 3| 3| 6| 7| 0| 2| 2| 1| 2| 3| 2| 2| 8| 9| 2| 0| 9| 2| 1|             
                                           | 7| 6| 6| 9| 9| 9| 5| 5| 2| 1| 5| 6| 7| 3| 5| 7| 9| 6| 3| 9| 1| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 6| 7| 5| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1|                                            |            |
                                           | 8| 2| 6| 3| 0| 5| 0| 0| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           |             +                                                            |   2        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperplasia, Basal Cell              |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |       +        +                                                         |   8        |
      Acanthosis                           |       2        1                                                         |      6  1.2|
      Acanthosis, Multifocal               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |          +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |       +        +                                                         |   8        |
      Sebaceous Gland, Hyperplasia         |                1                                                         |      4  1.8|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |          +                                                               |   3        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 6| 7| 5| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 5| 6| 3| 7| 3| 3| 5| 1|                                            |            |
                                           | 8| 2| 6| 3| 0| 5| 0| 0| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.5                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                         +              +           +                     |             
      Dysplasia                            |                                        2                                 |             
      Ulcer                                |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                      X   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X                                                                        |             
      Hepatodiaphragmatic Nodule           |                            X           X                       X         |             
      Inflammation, Chronic Active         |                                           1                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Bile Duct, Cyst                      |                            X                                             |             
      Bile Duct, Hyperplasia               |    3  2  4  1  4     2  2        2  2  2     2  2  3                 2  2|             
      Hepatocyte, Degeneration, Cystic     |                      2  2                                                |             
      Hepatocyte, Hyperplasia              |                                                                3         |             
      Hepatocyte, Vacuolization Cytoplasmic| 2                 2     3  3     2     3  1     2              2  2     3|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                               +                     |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Inflammation, Chronic Active    |    3                                               2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  3        2     2  1  2     2  2              2  3     2              2|             
      Artery, Inflammation, Chronic Active |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +              +  +                             +        +|             
      Acanthosis                           |                                  3                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 4                                                                        |             
      Ulcer                                |    3        3  3              3                                3        3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +     +           +                    +           +         |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       | 4                                                  2                     |             
      Necrosis                             |                                                                2         |             
      Ulcer                                |             3     2           3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 3  2  3     2  2  2  1  3  2  1  3  2  1  1  2     2  1  2     1  1  2   |             
      Mineralization                       | 4                                                                        |             
      Atrium, Thrombosis                   |          X     X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +           +  +  +  +  +  +           +     +                     |             
      Hyperplasia                          |                      2                                                   |             
      Vacuolization Cytoplasmic            |    2  2                 2  2  2  3           2     2                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +        +           +     +  +  +     +     +     +  +        +     +  +|             
      Hyperplasia                          | 2        2           2     2  2  2     2     2                       1  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3  3  2  2        2  4        2  3  4     3     4           3     2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hemorrhage            |                3                    4                                    |             
      Pars Distalis, Hyperplasia           |    2              2                                                  3   |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                             2     2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                1     2           2     2                          2  2   |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermia                             |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 4  2        4     3     2        2     1     2  1  2  3  2     2     2   |             
      Duct, Ectasia                        |                      3                                                  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    2  3     3  2        3     2  2  2     2  2           2  2  2  2      |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Germinal Epithelium, Degeneration    |    3  2                 3        3  2  3           2                     |             
      Interstitial Cell, Hyperplasia       |                                  2        3     2  2     2              2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Myelofibrosis               | 3                       2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +  +           +              +     +  +  +     +         |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +  +     +        +              +     +  +                 +|             
      Infiltration Cellular, Plasma Cell   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +  +           +  +              +     +  +        +        +|             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Inflammation, Chronic Active         |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         3              2     1                 4         |             
      Infarct                              |                                                                          |             
      Thrombosis                           |                                  X                                       |             
      Capsule, Thrombosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                 2           4     2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Cystic                  | 2  3  3  1  2  2  2     2  3  2     1     2  2     2  2  2  2  1  2     2|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                               4                                          |             
      Ulcer                                |                               3                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
      Acanthosis                           |                   1                 1     3     2                 1      |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                              +                           |             
      Cyst Epithelial Inclusion            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
      Hyperkeratosis                       |                                                                   2      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                              +                           |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
      Ulcer                                |                                           1                              |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                              +                           |             
      Dermis, Fibrosis                     |                                              2                           |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                   +                 +     +     +                 +      |             
      Sebaceous Gland, Hyperplasia         |                                           2     1                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 5| 6| 5| 7| 4| 7| 4| 6| 5| 4| 3| 7| 2| 7| 4|             
                             DAY ON TEST   | 9| 2| 3| 1| 3| 4| 6| 2| 2| 1| 3| 7| 5| 2| 5| 2| 5| 5| 9| 0| 6| 2| 9| 2| 6|             
                                           | 1| 2| 9| 0| 3| 9| 2| 6| 9| 3| 7| 9| 7| 9| 6| 9| 6| 9| 4| 8| 4| 9| 1| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Fracture                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         2        3     2                                 |             
      Hydrocephalus                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   2      |             
      Inflammation, Granulomatous          |                                  2                                       |             
      Mineralization                       | 4                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                                                                   3      |             
      Mucosa, Inflammation, Chronic Active |             3                          3     2              3     3      |             
      Mucosa, Ulcer                        |                                                                   3      |             
      Sinus, Foreign Body                  |                                        1                    3            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Inflammation, Chronic     |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                       +         |             
      Lens, Cataract                       |                                                                3         |             
      Retina, Atrophy                      |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 4  4  4  3  3  3  3  3  4  4  1  4  3  4  2  4  3  4  3  3  2  4  2  3  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
      Dysplasia                            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               X                 X        X        X     X|             
      Clear Cell Focus                     |       X                                                                 X|             
      Eosinophilic Focus                   |       X                                                           X      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |          2                                                               |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1     3  2  2  3  2  2     3     2  3        2              1  2  2  3  2|             
      Hepatocyte, Degeneration, Cystic     |       2           2  2     2                    3                       2|             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|          2        3                          2  3  4  2        2         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                  +        +     +      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                    3        3     2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2        2           1        2           2  2  1     2  2     1  1      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +        +                    +        +     +                  |             
      Acanthosis                           |                                        3                                 |             
      Inflammation, Chronic Active         |          2        3                                                      |             
      Mineralization                       |                                                 3                        |             
      Ulcer                                |                   2                                   3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +                    +     +     +                        |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                 3                        |             
      Necrosis                             |                                           2                              |             
      Ulcer                                |                3                    2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Aorta, Mineralization                |                                                 4                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 1     2     2     1  3  1  2  2  2     3     2  3  2  2     3  2  2  2  2|             
      Mineralization                       |                                                 4                        |             
      Atrium, Thrombosis                   |                X                    X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +     +  +     +           +  +  +     +  +  +  +     +     +      |             
      Hyperplasia                          |       2     2                    2     2                                 |             
      Vacuolization Cytoplasmic            |       2     2  2     2              2  2     2  1  4  2     2     2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +        +     +           +        +  +  +        +           +  +|             
      Hyperplasia                          |       4              3                    2  2  2                    2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2     2     4  2  3  3  2  2  3  4  3     4  2  3  3  2     3     3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                         3     3  3        2                              |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 2                             2                                      2  2|             
      Follicle, Cyst                       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermia                             |                                                                          |             
      Inflammation, Granulomatous          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2     2  2     2  4  2  2        3  4  2  2     2  2  2     2  2  2|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
      Inflammation, Chronic Active         |       2  2     2     1                       2  4           2     1  3   |             
      Inflammation, Granulomatous          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Germinal Epithelium, Degeneration    |       3  3              3     3  3     3           3                     |             
      Interstitial Cell, Hyperplasia       |                                  2                          1  2     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Myelofibrosis               |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                 +              +                          +   |             
      Mediastinal, Congestion              |          3                                                               |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +     +     +        +  +                       +   |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +                    +                          +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2                                            2                     |             
      Infarct                              |                            4                                             |             
      Thrombosis                           |                                                                          |             
      Capsule, Thrombosis                  |                                           X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                   2                                            2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  3  3  3  3  3  2  3  2  2     2        2  3     2  2  3     2  2  2|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                   4      |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                                                                          |             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
      Acanthosis                           |    1                             1     1                    3  2         |             
      Cyst                                 |                   1                                                      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                      +  +|             
      Cyst Epithelial Inclusion            |                                                                      2  X|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                      +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-Mass          |                                                                      +  +|             
      Dermis, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |    +              +              +     +                    +  +         |             
      Sebaceous Gland, Hyperplasia         |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 1| 7| 6| 6| 6| 6| 7| 6| 6| 7| 6| 6| 6| 5| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 0| 9| 4| 0| 2| 5| 1| 2| 1| 6| 8| 5| 2| 2| 4| 1| 5| 7| 5| 2| 2| 2|             
                                           | 9| 0| 9| 5| 2| 9| 9| 9| 5| 3| 9| 9| 2| 3| 1| 9| 2| 3| 0| 6| 5| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.5                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Fracture                     |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 3        3           2                 2        1  2        3     2      |             
      Hydrocephalus                        | 3        3                             2                          2      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                     +                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      1                                                   |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                 3                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                                                                          |             
      Mucosa, Inflammation, Chronic Active | 2                                                                        |             
      Mucosa, Ulcer                        |                                                                          |             
      Sinus, Foreign Body                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Inflammation, Chronic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Nephropathy, Chronic                 | 4  1  3  4  3  2  4  4  4  4  3  4  3  4  3  4  4  4  4  4  3  3  4  4  4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   3        |
      Dysplasia                            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |             X                                                            |      7     |
      Clear Cell Focus                     |             X                                                            |      3     |
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                   X                                                      |      4     |
      Inflammation, Chronic Active         |                2           2                                             |      3  1.7|
      Inflammation, Granulomatous          |          1  2                                                            |      3  1.7|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 3  2     2  2        4  4  2                                             |     38  2.3|
      Hepatocyte, Degeneration, Cystic     |    2                                                                     |      9  2.1|
      Hepatocyte, Hyperplasia              |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|          1     2           2                                             |     21  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +                                                            |   8        |
      Artery, Inflammation, Chronic Active |             4                                                            |      1  4.0|
      Fat, Inflammation, Chronic Active    |    3                                                                     |      6  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |       2     1     3                                                      |     26  1.8|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  13        |
      Acanthosis                           |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      2  3.5|
      Ulcer                                |                                                                          |      8  2.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  11        |
      Hyperplasia                          | 2                                                                        |      1  2.0|
      Mineralization                       |                                                                          |      3  3.0|
      Necrosis                             |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Chronic                | 2  2  2  1  1  2  2  1  2  2                                             |     50  1.9|
      Mineralization                       |                                                                          |      2  4.0|
      Atrium, Thrombosis                   |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +                                                            |  24        |
      Hyperplasia                          |             2                                                            |      6  2.0|
      Vacuolization Cytoplasmic            |                                                                          |     20  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +           +                                                |  29        |
      Hyperplasia                          | 2  2  2     2           2                                                |     21  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          | 2  3  4     2        3  2                                                |     39  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Hemorrhage            |                                                                          |      2  3.5|
      Pars Distalis, Hyperplasia           |    2        3  2        4                                                |     11  2.6|
      Pars Distalis, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 | X                                                                        |      1     |
      C-Cell, Hyperplasia                  | 2                                                                        |     11  1.9|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Aspermia                             |                3  3                                                      |      2  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 2  2  2     2  2  2  2                                                   |     38  2.2|
      Duct, Ectasia                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                2        1  2                                             |     26  2.1|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                   3                                                      |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Germinal Epithelium, Degeneration    |                2  3  3                                                   |     17  2.8|
      Interstitial Cell, Hyperplasia       |          2        2        2                                             |     13  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femoral, Myelofibrosis               |       2                                                                  |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  14        |
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +     +                                                |  17        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |  14        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |             2                                                            |      7  2.3|
      Infarct                              |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
      Capsule, Thrombosis                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  M  +  M  +                                             |  51        |
      Depletion Lymphoid                   |                2           2                                             |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Hyperplasia, Cystic                  | 2  2  1  3  2     2  3  3  2                                             |     49  2.2|
      Duct, Cyst                           |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  4.0|
      Cyst Epithelial Inclusion            |                            X                                             |      1     |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +                                                                        |   1        |
      Acanthosis                           | 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
      Acanthosis                           |          1     2  1        3                                             |     14  1.6|
      Cyst                                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |                      +                                                   |   4        |
      Cyst Epithelial Inclusion            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
      Hyperkeratosis                       |                   2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |                      +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
      Ulcer                                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-Mass          |                      +                                                   |   4        |
      Dermis, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       |          +     +  +        +                                             |  16        |
      Sebaceous Gland, Hyperplasia         |                            2                                             |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Tarsal, Fracture                     |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |          2                 2                                             |     13  2.2|
      Hydrocephalus                        |                            2                                             |      6  2.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  M                                             |  59        |
      Lumen, Hemorrhage                    |                                                                          |      1  3.0|
      Mucosa, Inflammation, Chronic Active |                                                                          |      6  2.7|
      Mucosa, Ulcer                        |                                                                          |      1  3.0|
      Sinus, Foreign Body                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Submucosa, Inflammation, Chronic     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05102-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BENZETHONIUM CHLORIDE                                   Date: 04/23/97  
Route: DERMAL,SOLUTION                                                                                            Time: 12:54:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 4| 3| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 4| 2| 5| 9| 6| 2| 2|                                            |            |
                                           | 9| 9| 5| 4| 9| 6| 6| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.5                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   3        |
      Lens, Cataract                       |             4                                                            |      2  3.5|
      Retina, Atrophy                      |             4                                                            |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy, Chronic                 | 4  4  4  4  3  3  2  3  3  2                                             |     60  3.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------