National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1777

TDMS Study 05103-04 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL


NTP Experiment-Test: 05103-04                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 19:06:50




       Facility:  Southern Research Institute

       Chemical CAS #:  3296-90-0

       Lock Date:  02/12/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8           10            9           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           14           14           29                                     
    Natural Death                                      6            6           11           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           30           26           11                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (59)         (59)         (58)                                   
      Mucosa, Hyperplasia                                                                     1 (2%)                                
   Gallbladder                                        (56)         (57)         (55)         (55)                                   
      Dilatation                                                                 2 (4%)       1 (2%)                                
   Intestine Large, Cecum                             (60)         (60)         (58)         (60)                                   
      Edema                                            3 (5%)       1 (2%)       4 (7%)       4 (7%)                                
   Intestine Small, Duodenum                          (59)         (60)         (56)         (59)                                   
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (57)         (59)         (58)         (57)                                   
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Small, Ileum                             (59)         (60)         (56)         (57)                                   
      Amyloid Deposition                                            1 (2%)                                                          
   Liver                                              (59)         (60)         (59)         (59)                                   
      Basophilic Focus                                 1 (2%)       4 (7%)       2 (3%)       2 (3%)                                
      Clear Cell Focus                                              1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Degeneration, Fatty                              1 (2%)                    1 (2%)       3 (5%)                                
      Developmental Malformation                       1 (2%)                                 1 (2%)                                
      Eosinophilic Focus                               4 (7%)       2 (3%)       3 (5%)       6 (10%)                               
      Hematopoietic Cell Proliferation                 9 (15%)      6 (10%)      4 (7%)      15 (25%)                               
      Hyperplasia, Lymphoid                            3 (5%)       1 (2%)       1 (2%)       2 (3%)                                
      Inflammation, Subacute                           7 (12%)      3 (5%)       2 (3%)       2 (3%)                                
      Mixed Cell Focus                                 1 (2%)       2 (3%)       3 (5%)       1 (2%)                                
      Centrilobular, Necrosis                                       1 (2%)       2 (3%)       2 (3%)                                
      Kupffer Cell, Hyperplasia                        6 (10%)      4 (7%)       7 (12%)     12 (20%)                               
      Kupffer Cell, Pigmentation                       2 (3%)                    1 (2%)       1 (2%)                                
      Lobules, Necrosis                                4 (7%)       7 (12%)      6 (10%)      6 (10%)                               
   Mesentery                                          (4)          (7)          (8)          (8)                                    
      Inflammation, Chronic                                                      2 (25%)                                            
      Fat, Necrosis                                    4 (100%)     6 (86%)      4 (50%)      7 (88%)                               
   Pancreas                                           (59)         (60)         (58)         (58)                                   
      Atrophy                                          1 (2%)       3 (5%)       3 (5%)       5 (9%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst                                             1 (2%)       2 (3%)       3 (5%)       5 (9%)                                
      Focal Cellular Change                                         1 (2%)                    4 (7%)                                
      Hyperplasia, Lymphoid                                         2 (3%)                    2 (3%)                                
      Acinar Cell, Cytoplasmic Alteration              4 (7%)       3 (5%)       2 (3%)       2 (3%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia, Lymphoid                            4 (7%)       4 (7%)       6 (10%)      5 (8%)                                
   Stomach, Forestomach                               (59)         (60)         (60)         (59)                                   
      Diverticulum                                                  1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)       1 (2%)                                
      Ulcer                                            5 (8%)       2 (3%)       7 (12%)      6 (10%)                               
      Mucosa, Hyperkeratosis                                                                  1 (2%)                                
      Mucosa, Hyperplasia                             10 (17%)      5 (8%)      16 (27%)      9 (15%)                               
   Stomach, Glandular                                 (59)         (60)         (58)         (59)                                   
      Ectopic Tissue                                   1 (2%)                                                                       
      Edema                                            1 (2%)                    1 (2%)       2 (3%)                                
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Subacute                           3 (5%)       1 (2%)       1 (2%)                                             
      Mineralization                                                             1 (2%)       1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
      Mucosa, Hyperplasia                              1 (2%)       1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Inflammation, Subacute                           1 (100%)                                                                     
   Heart                                              (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Mineralization                                                             1 (2%)       1 (2%)                                
      Thrombosis                                                    1 (2%)       1 (2%)       1 (2%)                                
      Myocardium, Necrosis                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (60)         (59)                                   
      Accessory Adrenal Cortical Nodule                5 (8%)       6 (10%)      6 (10%)      6 (10%)                               
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                                          2 (3%)                                                          
      Degeneration, Fatty                                           1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (5%)       2 (3%)       2 (3%)       2 (3%)                                
      Hyperplasia, Focal                                                                      1 (2%)                                
      Hypertrophy, Focal                               2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Capsule, Hyperplasia                             1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (59)         (60)         (60)         (59)                                   
      Atrophy                                          1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
   Islets, Pancreatic                                 (59)         (60)         (58)         (59)                                   
      Hyperplasia                                      2 (3%)       2 (3%)                    3 (5%)                                
   Parathyroid Gland                                  (52)         (54)         (58)         (56)                                   
      Cyst                                             2 (4%)       4 (7%)       3 (5%)                                             
      Ectopic Tissue                                   1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (58)         (58)         (57)         (56)                                   
      Pars Distalis, Angiectasis                       3 (5%)       2 (3%)       5 (9%)       1 (2%)                                
      Pars Distalis, Cyst                              1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                9 (16%)      4 (7%)       5 (9%)       8 (14%)                               
   Thyroid Gland                                      (59)         (60)         (60)         (59)                                   
      Degeneration, Cystic                            12 (20%)      7 (12%)     14 (23%)     14 (24%)                               
      Ectopic Thymus                                                             1 (2%)                                             
      Follicle, Cyst                                   3 (5%)       4 (7%)       2 (3%)       2 (3%)                                
      Follicular Cell, Hyperplasia                    13 (22%)     15 (25%)      9 (15%)      3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (58)         (60)         (60)                                   
      Ectasia                                          9 (15%)      9 (16%)     10 (17%)     11 (18%)                               
      Inflammation, Chronic                            2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Pigmentation                                                               2 (3%)                                             
   Ovary                                              (59)         (59)         (60)         (57)                                   
      Angiectasis                                      9 (15%)      5 (8%)      18 (30%)     12 (21%)                               
      Cyst                                            11 (19%)     13 (22%)     11 (18%)     17 (30%)                               
      Inflammation, Suppurative                        8 (14%)      2 (3%)       4 (7%)       6 (11%)                               
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                      2 (3%)       6 (10%)     16 (27%)     17 (28%)                               
      Hydrometra                                      10 (17%)      6 (10%)      8 (13%)      5 (8%)                                
      Hyperplasia, Cystic                             53 (88%)     51 (85%)     52 (87%)     55 (92%)                               
      Inflammation, Granulomatous                                                1 (2%)       1 (2%)                                
      Inflammation, Suppurative                       11 (18%)      3 (5%)       6 (10%)      3 (5%)                                
      Metaplasia, Squamous                             4 (7%)       3 (5%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hypercellularity                                13 (22%)     15 (25%)     15 (25%)     26 (43%)                               
      Myelofibrosis                                    7 (12%)      5 (8%)       6 (10%)      7 (12%)                               
      Necrosis                                         1 (2%)                                                                       
   Lymph Node                                         (9)          (12)         (6)          (9)                                    
      Bronchial, Hyperplasia, Lymphoid                 1 (11%)                                                                      
      Iliac, Hematopoietic Cell Proliferation          1 (11%)                   1 (17%)      1 (11%)                               
      Iliac, Hyperplasia, Lymphoid                     6 (67%)      1 (8%)                    3 (33%)                               
      Inguinal, Hyperplasia, Lymphoid                               1 (8%)                                                          
      Mediastinal, Hyperplasia, Lymphoid               2 (22%)                   1 (17%)      3 (33%)                               
      Mediastinal, Inflammation, Suppurative                                                  1 (11%)                               
      Pancreatic, Hematopoietic Cell Proliferation                                            1 (11%)                               
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (11%)                               
      Pancreatic, Necrosis                                          1 (8%)                                                          
      Renal, Hyperplasia, Lymphoid                     6 (67%)      2 (17%)                   5 (56%)                               
   Lymph Node, Mandibular                             (56)         (56)         (59)         (56)                                   
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                    2 (4%)                                
      Hemorrhage                                                                 1 (2%)       2 (4%)                                
      Hyperplasia, Lymphoid                            5 (9%)       7 (13%)      8 (14%)     11 (20%)                               
      Pigmentation                                     6 (11%)      5 (9%)                    7 (13%)                               
   Lymph Node, Mesenteric                             (57)         (58)         (55)         (58)                                   
      Angiectasis                                      1 (2%)       1 (2%)       2 (4%)                                             
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       1 (2%)       3 (5%)                                
      Hemorrhage                                       4 (7%)       4 (7%)       1 (2%)       4 (7%)                                
      Hyperplasia, Lymphoid                            6 (11%)      4 (7%)       4 (7%)       9 (16%)                               
      Pigmentation                                                                            1 (2%)                                
   Spleen                                             (59)         (60)         (59)         (60)                                   
      Hematopoietic Cell Proliferation                20 (34%)     25 (42%)     26 (44%)     41 (68%)                               
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       2 (3%)       1 (2%)                                             
      Pigmentation, Hemosiderin                        3 (5%)       3 (5%)       2 (3%)       4 (7%)                                
      Lymphoid Follicle, Atrophy                       1 (2%)                                                                       
      Lymphoid Follicle, Hyperplasia                   8 (14%)      3 (5%)       6 (10%)      5 (8%)                                
      Red Pulp, Atrophy                                1 (2%)                                                                       
   Thymus                                             (54)         (57)         (55)         (52)                                   
      Atrophy                                          2 (4%)       3 (5%)       4 (7%)       4 (8%)                                
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (60)         (59)         (59)                                   
      Hyperplasia, Cystic                              1 (2%)       3 (5%)       1 (2%)       2 (3%)                                
      Hyperplasia, Lobular                             1 (2%)       2 (3%)       1 (2%)                                             
   Skin                                               (59)         (60)         (60)         (60)                                   
      Acanthosis                                                    1 (2%)                                                          
      Edema                                                                      1 (2%)       1 (2%)                                
      Inflammation, Subacute                                        1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                     2 (3%)                    3 (5%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                                   4 (7%)       2 (3%)                                             
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                                                      2 (3%)                                             
      Necrosis                                                                   1 (2%)                                             
   Peripheral Nerve                                   (1)          (1)          (1)          (1)                                    
      Atrophy                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)       1 (2%)                                             
      Foreign Body                                                  1 (2%)                    1 (2%)                                
      Hemorrhage                                       2 (3%)       2 (3%)       3 (5%)       3 (5%)                                
      Hyperplasia, Lymphoid                            3 (5%)       5 (8%)       7 (12%)      1 (2%)                                
      Infiltration Cellular, Histiocyte                2 (3%)       5 (8%)       5 (8%)       5 (8%)                                
      Inflammation, Subacute                           1 (2%)       1 (2%)       3 (5%)       2 (3%)                                
      Mineralization                                                             1 (2%)                                             
      Thrombosis                                       1 (2%)       3 (5%)       2 (3%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (3%)       3 (5%)       8 (13%)     15 (25%)                               
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                          3 (5%)                    2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)          (3)          (7)                                    
      Cataract                                                      2 (100%)     1 (33%)      2 (29%)                               
      Inflammation, Chronic                                         1 (50%)                   5 (71%)                               
      Phthisis Bulbi                                                             2 (67%)      1 (14%)                               
   Harderian Gland                                    (22)         (32)         (31)         (40)                                   
      Hyperplasia                                      1 (5%)       1 (3%)       3 (10%)      1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (60)         (59)                                   
      Casts Protein                                   19 (32%)     22 (37%)     16 (27%)      8 (14%)                               
      Cyst                                             2 (3%)                    2 (3%)       1 (2%)                                
      Glomerulosclerosis                               1 (2%)       1 (2%)                                                          
      Hydronephrosis                                                                          1 (2%)                                
      Hyperplasia, Lymphoid                            9 (15%)     11 (18%)      7 (12%)      4 (7%)                                
      Metaplasia, Osseous                              1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Mineralization                                   1 (2%)                    2 (3%)       1 (2%)                                
      Renal Tubule, Atrophy                            1 (2%)                                                                       
      Renal Tubule, Cytoplasmic Alteration             1 (2%)       1 (2%)       2 (3%)                                             
      Renal Tubule, Dilatation                         3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
      Renal Tubule, Necrosis                                                     2 (3%)       1 (2%)                                
      Renal Tubule, Pigmentation                       1 (2%)                    1 (2%)       1 (2%)                                
      Renal Tubule, Regeneration                       7 (12%)     11 (18%)     11 (18%)      7 (12%)                               
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
   Urinary Bladder                                    (59)         (60)         (59)         (60)                                   
      Edema                                            1 (2%)                    2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (3%)       3 (5%)       3 (5%)       3 (5%)                                
      Inflammation, Subacute                                                     2 (3%)       1 (2%)                                
      Mucosa, Hyperplasia                              1 (2%)                    2 (3%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            3            4            5                                     
    Moribund Sacrifice                                 3           12           11           13                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           36           35           30                                     
  Missing                                                                                     1                                     
  Animals Examined Microscopically                    60           60           60           59                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (58)         (59)         (59)         (55)                                   
      Edema                                                                      1 (2%)                                             
   Intestine Large, Rectum                            (58)         (59)         (58)         (58)                                   
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Large, Cecum                             (59)         (58)         (58)         (58)                                   
      Edema                                            3 (5%)       4 (7%)       1 (2%)       8 (14%)                               
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (58)         (59)         (58)                                   
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Small, Ileum                             (58)         (57)         (57)         (58)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Peyer's Patch, Hyperplasia                       2 (3%)                                                                       
   Liver                                              (59)         (60)         (59)         (59)                                   
      Basophilic Focus                                 3 (5%)       3 (5%)       4 (7%)       3 (5%)                                
      Clear Cell Focus                                 6 (10%)      7 (12%)      3 (5%)       3 (5%)                                
      Congestion                                                    1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Developmental Malformation                                                 1 (2%)                                             
      Eosinophilic Focus                               4 (7%)       4 (7%)       7 (12%)      3 (5%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)                    4 (7%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Subacute                           3 (5%)       2 (3%)       6 (10%)      3 (5%)                                
      Mineralization                                                             2 (3%)       2 (3%)                                
      Mixed Cell Focus                                 5 (8%)       2 (3%)       1 (2%)       2 (3%)                                
      Necrosis                                                                   1 (2%)       1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
      Hepatocyte, Nuclear Alteration                                1 (2%)       3 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Vacuolization Cytoplasmic                         1 (2%)                                                          
      Kupffer Cell, Hyperplasia                        1 (2%)       2 (3%)       2 (3%)       5 (8%)                                
      Kupffer Cell, Pigmentation                       1 (2%)                    2 (3%)       2 (3%)                                
      Lobules, Necrosis                                1 (2%)       4 (7%)       4 (7%)       3 (5%)                                
   Mesentery                                          (3)          (2)          (1)          (4)                                    
      Fat, Necrosis                                    3 (100%)                  1 (100%)     2 (50%)                               
   Pancreas                                           (59)         (60)         (59)         (59)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Acinar Cell, Cytoplasmic Alteration              1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
   Salivary Glands                                    (59)         (60)         (59)         (59)                                   
      Hyperplasia, Lymphoid                            2 (3%)       1 (2%)       3 (5%)       1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (59)         (60)         (60)         (58)                                   
      Diverticulum                                                  1 (2%)                                                          
      Ulcer                                            2 (3%)                    1 (2%)       3 (5%)                                
      Mucosa, Hyperplasia                              4 (7%)       1 (2%)       4 (7%)       4 (7%)                                
   Stomach, Glandular                                 (59)         (60)         (59)         (58)                                   
      Ectopic Tissue                                                                          1 (2%)                                
      Edema                                                         1 (2%)       1 (2%)                                             
      Erosion                                                       1 (2%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Mucosa, Hyperplasia                                           2 (3%)                    2 (3%)                                
   Tooth                                              (13)         (2)          (4)          (3)                                    
      Dysplasia                                       13 (100%)     2 (100%)     4 (100%)     3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (59)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Mineralization                                                             1 (2%)       3 (5%)                                
      Thrombosis                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (60)         (60)         (59)                                   
      Accessory Adrenal Cortical Nodule                3 (5%)       4 (7%)       3 (5%)       2 (3%)                                
      Cyst                                                                       1 (2%)                                             
      Hyperplasia, Focal                               4 (7%)       4 (7%)       7 (12%)      3 (5%)                                
      Hypertrophy, Focal                              14 (24%)     20 (33%)     17 (28%)     10 (17%)                               
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Capsule, Hyperplasia                             5 (9%)       4 (7%)       5 (8%)       5 (8%)                                
   Adrenal Medulla                                    (59)         (59)         (60)         (59)                                   
      Hyperplasia                                      1 (2%)       2 (3%)                                                          
   Islets, Pancreatic                                 (59)         (59)         (59)         (59)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                     17 (29%)     16 (27%)     12 (20%)      8 (14%)                               
   Parathyroid Gland                                  (57)         (56)         (56)         (58)                                   
      Cyst                                             2 (4%)       2 (4%)       6 (11%)      1 (2%)                                
   Pituitary Gland                                    (57)         (54)         (59)         (54)                                   
      Pars Distalis, Cyst                              2 (4%)       3 (6%)       2 (3%)       3 (6%)                                
      Pars Distalis, Hyperplasia, Focal                1 (2%)                                                                       
   Thyroid Gland                                      (59)         (60)         (59)         (59)                                   
      Degeneration, Cystic                            10 (17%)      9 (15%)     12 (20%)      6 (10%)                               
      Follicle, Cyst                                   2 (3%)       3 (5%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                     6 (10%)      6 (10%)      4 (7%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Cyst                                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)          (2)                                                              
      Dilatation                                       2 (100%)     2 (100%)                                                        
   Epididymis                                         (59)         (60)         (60)         (59)                                   
      Atypia Cellular                                                            1 (2%)                                             
      Granuloma Sperm                                                            1 (2%)                                             
      Hypospermia                                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Spermatocele                                     1 (2%)       2 (3%)                    2 (3%)                                
   Preputial Gland                                    (58)         (58)         (59)         (58)                                   
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Atrophy                                          2 (3%)                    1 (2%)                                             
      Ectasia                                         28 (48%)     23 (40%)     30 (51%)     28 (48%)                               
      Hyperplasia                                                                1 (2%)       1 (2%)                                
      Inflammation, Chronic                           25 (43%)     19 (33%)     22 (37%)     14 (24%)                               
      Inflammation, Granulomatous                                                             1 (2%)                                
      Inflammation, Suppurative                        8 (14%)     13 (22%)     15 (25%)     11 (19%)                               
   Prostate                                           (59)         (60)         (60)         (57)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
   Seminal Vesicle                                    (59)         (60)         (60)         (59)                                   
      Dilatation                                      15 (25%)     10 (17%)     11 (18%)      8 (14%)                               
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                       2 (3%)       1 (2%)                                                          
      Inflammation, Chronic                            2 (3%)       1 (2%)                                                          
   Testes                                             (59)         (60)         (60)         (59)                                   
      Granuloma Sperm                                               1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
      Seminiferous Tubule, Atrophy                     3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)         (59)                                   
      Hypercellularity                                 5 (8%)      12 (20%)     11 (18%)     13 (22%)                               
      Necrosis                                                      1 (2%)                    1 (2%)                                
   Lymph Node                                         (3)          (3)          (5)          (7)                                    
      Bronchial, Hyperplasia, Lymphoid                                                        1 (14%)                               
      Iliac, Hyperplasia, Lymphoid                                  1 (33%)                                                         
      Inguinal, Hematopoietic Cell Proliferation                                              1 (14%)                               
      Inguinal, Hyperplasia, Lymphoid                  2 (67%)      2 (67%)      1 (20%)      3 (43%)                               
      Inguinal, Pigmentation                           1 (33%)                                                                      
      Mediastinal, Hematopoietic Cell Proliferation                                           1 (14%)                               
      Mediastinal, Hyperplasia, Lymphoid                                                      1 (14%)                               
      Renal, Hemorrhage                                1 (33%)                                                                      
      Renal, Hyperplasia, Lymphoid                     1 (33%)                                                                      
   Lymph Node, Mandibular                             (56)         (58)         (59)         (55)                                   
      Atrophy                                                       2 (3%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)                    2 (4%)                                
      Hyperplasia, Lymphoid                            1 (2%)       3 (5%)       1 (2%)       5 (9%)                                
      Pigmentation                                     6 (11%)      3 (5%)       6 (10%)      3 (5%)                                
   Lymph Node, Mesenteric                             (58)         (58)         (59)         (58)                                   
      Angiectasis                                                                2 (3%)       2 (3%)                                
      Atrophy                                                       1 (2%)                                                          
      Hematopoietic Cell Proliferation                              4 (7%)       3 (5%)       5 (9%)                                
      Hemorrhage                                      19 (33%)     15 (26%)     18 (31%)     22 (38%)                               
      Hyperplasia, Lymphoid                            4 (7%)      12 (21%)      8 (14%)      4 (7%)                                
      Pigmentation                                     1 (2%)       1 (2%)                    1 (2%)                                
   Spleen                                             (59)         (60)         (59)         (59)                                   
      Hematopoietic Cell Proliferation                10 (17%)     22 (37%)     16 (27%)     19 (32%)                               
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Lymphoid Follicle, Atrophy                       1 (2%)       4 (7%)                    1 (2%)                                
      Lymphoid Follicle, Hyperplasia                   1 (2%)                    1 (2%)       1 (2%)                                
      Red Pulp, Atrophy                                             2 (3%)                    1 (2%)                                
   Thymus                                             (53)         (57)         (50)         (52)                                   
      Atrophy                                                       4 (7%)                    4 (8%)                                
      Congestion                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (59)                                   
      Acanthosis                                                    1 (2%)       2 (3%)                                             
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Ulcer                                                         1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (59)                                   
      Hyperostosis                                                  2 (3%)                    3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (59)                                   
      Compression                                                                             1 (2%)                                
      Cyst                                             1 (2%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (59)                                   
      Congestion                                                    1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       3 (5%)       3 (5%)                                
      Hyperplasia, Lymphoid                            3 (5%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                6 (10%)      8 (13%)      5 (8%)      10 (17%)                               
      Inflammation, Subacute                                        1 (2%)                                                          
      Thrombosis                                       1 (2%)                    1 (2%)       2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 7 (12%)      7 (12%)      6 (10%)     11 (19%)                               
   Nose                                               (59)         (60)         (60)         (59)                                   
      Exudate                                          1 (2%)       1 (2%)       1 (2%)       3 (5%)                                
      Foreign Body                                     1 (2%)                                                                       
      Mucosa, Hyperplasia                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)          (4)          (9)                                    
      Cataract                                                      1 (50%)      1 (25%)      2 (22%)                               
      Inflammation, Chronic                                         1 (50%)      3 (75%)      2 (22%)                               
      Phthisis Bulbi                                                1 (50%)                                                         
      Cornea, Hyperplasia                                                        1 (25%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05103-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Harderian Gland                                    (26)         (31)         (33)         (36)                                   
      Hyperplasia                                                   1 (3%)       2 (6%)       3 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (60)         (59)                                   
      Casts Protein                                    7 (12%)     14 (23%)     10 (17%)      5 (8%)                                
      Cyst                                            13 (22%)     13 (22%)     10 (17%)     12 (20%)                               
      Hydronephrosis                                   1 (2%)       4 (7%)       2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                            3 (5%)       4 (7%)       5 (8%)       2 (3%)                                
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Metaplasia, Osseous                              1 (2%)       1 (2%)       2 (3%)                                             
      Mineralization                                  41 (69%)     35 (58%)     41 (68%)     33 (56%)                               
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Atrophy                            1 (2%)                    1 (2%)       2 (3%)                                
      Renal Tubule, Casts Protein                                   1 (2%)                                                          
      Renal Tubule, Dilatation                         2 (3%)       1 (2%)       3 (5%)       1 (2%)                                
      Renal Tubule, Hyperplasia                                                               2 (3%)                                
      Renal Tubule, Necrosis                           1 (2%)       1 (2%)                                                          
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
      Renal Tubule, Regeneration                      50 (85%)     47 (78%)     53 (88%)     44 (75%)                               
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
   Urethra                                            (1)                                                                           
      Concretion                                       1 (100%)                                                                     
      Inflammation, Subacute                           1 (100%)                                                                     
   Urinary Bladder                                    (59)         (60)         (59)         (59)                                   
      Dilatation                                       2 (3%)                                                                       
      Edema                                                         1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mucosa, Hyperplasia                                           1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.