National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1781

TDMS Study 05103-04 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL


NTP Experiment-Test: 05103-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 19:06:50




       Facility:  Southern Research Institute

       Chemical CAS #:  3296-90-0

       Lock Date:  02/12/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8           10            9           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           14           14           29                                     
    Natural Death                                      6            6           11           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           30           26           11                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (56)         (57)         (55)         (55)                                   
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Intestine Large, Colon                             (60)         (60)         (58)         (59)                                   
      Hemangioma                                                                              1 (2%)                                
   Intestine Large, Rectum                            (58)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Large, Cecum                             (60)         (60)         (58)         (60)                                   
      Hemangioma                                                                 1 (2%)                                             
   Intestine Small, Jejunum                           (57)         (59)         (58)         (57)                                   
   Liver                                              (59)         (60)         (59)         (59)                                   
      Hepatocellular Carcinoma                         4 (7%)       8 (13%)      5 (8%)       1 (2%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                                 2 (3%)                                
      Hepatocellular Adenoma                          13 (22%)      9 (15%)      4 (7%)      14 (24%)                               
      Hepatocellular Adenoma, Multiple                 3 (5%)       3 (5%)       2 (3%)       3 (5%)                                
      Histiocytic Sarcoma                                           2 (3%)       2 (3%)       1 (2%)                                
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Mesentery                                          (4)          (7)          (8)          (8)                                    
      Sarcoma                                                                                 1 (13%)                               
      Yolk Sac Carcinoma, Metastatic, Ovary                                      1 (13%)                                            
   Pancreas                                           (59)         (60)         (58)         (58)                                   
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (59)         (60)         (60)         (59)                                   
      Squamous Cell Papilloma                                       1 (2%)       5 (8%)       4 (7%)                                
   Stomach, Glandular                                 (59)         (60)         (58)         (59)                                   
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Tongue                                                          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (60)         (59)                                   
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
      Capsule, Carcinoma                                            1 (2%)                                                          
   Adrenal Medulla                                    (59)         (60)         (60)         (59)                                   
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (60)         (58)         (59)                                   
      Adenoma                                          1 (2%)       3 (5%)       2 (3%)       2 (3%)                                
   Pituitary Gland                                    (58)         (58)         (57)         (56)                                   
      Pars Distalis, Adenoma                           4 (7%)       8 (14%)      3 (5%)       5 (9%)                                
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (59)         (60)         (60)         (59)                                   
      Follicular Cell, Adenoma                         3 (5%)       1 (2%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (59)         (60)         (57)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                                               1 (2%)                                
      Granulosa Cell Tumor Benign                                                1 (2%)       1 (2%)                                
      Luteoma                                                                    2 (3%)                                             
      Yolk Sac Carcinoma                                                         1 (2%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Carcinoma                                                     1 (2%)       2 (3%)       2 (3%)                                
      Deciduoma Benign                                              1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Polyp Adenomatous                                             1 (2%)                                                          
      Polyp Stromal                                    3 (5%)       1 (2%)                    1 (2%)                                
      Sarcoma Stromal                                               1 (2%)                    2 (3%)                                
   Vagina                                                                                    (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Lymph Node                                         (9)          (12)         (6)          (9)                                    
      Mediastinal, Sarcoma, Metastatic, Skin                                     1 (17%)                                            
      Renal, Histiocytic Sarcoma                                    1 (8%)                                                          
      Renal, Sarcoma, Metastatic, Skin                                                        1 (11%)                               
   Lymph Node, Mandibular                             (56)         (56)         (59)         (56)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (57)         (58)         (55)         (58)                                   
      Histiocytic Sarcoma                                           3 (5%)       2 (4%)       1 (2%)                                
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Spleen                                             (59)         (60)         (59)         (60)                                   
      Hemangioma                                                                              1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (54)         (57)         (55)         (52)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (60)         (59)         (59)                                   
      Adenoacanthoma                                                                          1 (2%)                                
      Carcinoma                                                                  1 (2%)       2 (3%)                                
      Carcinoma, Multiple                                                                     1 (2%)                                
   Skin                                               (59)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                       1 (2%)                    1 (2%)                                
      Sebaceous Gland, Carcinoma                       1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                                    2 (3%)                                
      Subcutaneous Tissue, Sarcoma                                               4 (7%)      11 (18%)                               
      Subcutaneous Tissue, Sarcoma, Multiple                        1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                     1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (1)          (1)          (1)          (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     3 (5%)       3 (5%)       7 (12%)     17 (28%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                    2 (3%)       2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       2 (3%)       5 (8%)       4 (7%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       2 (3%)       3 (5%)       1 (2%)                                
      Carcinoma, Metastatic, Mammary Gland                                                    1 (2%)                                
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       2 (3%)       1 (2%)                                             
      Histiocytic Sarcoma                                           2 (3%)       2 (3%)       1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (22)         (32)         (31)         (40)                                   
      Adenoma                                          3 (14%)      7 (22%)      8 (26%)     18 (45%)                               
      Carcinoma                                        1 (5%)       6 (19%)      5 (16%)      7 (18%)                               
      Bilateral, Adenoma                                                                      1 (3%)                                
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Urinary Bladder                                    (59)         (60)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)       4 (7%)       2 (3%)       1 (2%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Lymphoma Malignant Lymphocytic                   2 (3%)                    1 (2%)       1 (2%)                                
      Lymphoma Malignant Mixed                         3 (5%)       7 (12%)      7 (12%)      3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell                      3 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          43          46          49                                       
     Total Primary Neoplasms                           54          80          78         120                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28          30          31          41                                       
     Total Benign Neoplasms                            37          43          41          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          32          31          36                                       
     Total Malignant Neoplasms                         17          37          37          48                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           6           7           4                                       
     Total Metastatic Neoplasm                          4           8           8           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            3            4            5                                     
    Moribund Sacrifice                                 3           12           11           13                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           36           35           30                                     
  Missing                                                                                     1                                     
  Animals Examined Microscopically                    60           60           60           59                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (58)         (53)         (59)         (52)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                                                          
   Intestine Large, Cecum                             (59)         (58)         (58)         (58)                                   
   Intestine Small, Duodenum                          (59)         (59)         (59)         (56)                                   
   Intestine Small, Jejunum                           (59)         (58)         (59)         (58)                                   
      Carcinoma                                                                               2 (3%)                                
   Intestine Small, Ileum                             (58)         (57)         (57)         (58)                                   
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (59)         (60)         (59)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hemangioma                                                    1 (2%)                    1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       2 (3%)                    2 (3%)                                
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                        11 (19%)     15 (25%)     14 (24%)      9 (15%)                               
      Hepatocellular Carcinoma, Multiple                            2 (3%)       1 (2%)                                             
      Hepatocellular Adenoma                          16 (27%)     19 (32%)     12 (20%)     12 (20%)                               
      Hepatocellular Adenoma, Multiple                 6 (10%)      5 (8%)       8 (14%)      9 (15%)                               
      Histiocytic Sarcoma                                           2 (3%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        2 (3%)                                
   Mesentery                                          (3)          (2)          (1)          (4)                                    
      Hemangiosarcoma                                                                         1 (25%)                               
      Hepatoblastoma, Metastatic, Liver                             1 (50%)                                                         
      Histiocytic Sarcoma                                           1 (50%)                                                         
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (25%)                               
                                                             Page   8                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Pancreas                                           (59)         (60)         (59)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Pharynx                                                                      (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Stomach, Forestomach                               (59)         (60)         (60)         (58)                                   
      Squamous Cell Carcinoma                                                    1 (2%)       2 (3%)                                
      Squamous Cell Papilloma                                       3 (5%)       2 (3%)       3 (5%)                                
   Stomach, Glandular                                 (59)         (60)         (59)         (58)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (60)         (60)         (59)                                   
      Adenoma                                                       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Capsule, Adenoma                                 1 (2%)                                                                       
   Adrenal Medulla                                    (59)         (59)         (60)         (59)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (59)         (59)         (59)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
   Pituitary Gland                                    (57)         (54)         (59)         (54)                                   
      Pars Distalis, Carcinoma                                                                1 (2%)                                
   Thyroid Gland                                      (59)         (60)         (59)         (59)                                   
      Follicular Cell, Adenoma                                      3 (5%)                    4 (7%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Preputial Gland                                    (58)         (58)         (59)         (58)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
   Seminal Vesicle                                    (59)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
   Testes                                             (59)         (60)         (60)         (59)                                   
      Hemangioma                                                                              1 (2%)                                
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)         (59)                                   
      Hemangiosarcoma                                               2 (3%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (3)          (3)          (5)          (7)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (20%)                                            
   Lymph Node, Mandibular                             (56)         (58)         (59)         (55)                                   
   Lymph Node, Mesenteric                             (58)         (58)         (59)         (58)                                   
      Histiocytic Sarcoma                                           2 (3%)                                                          
   Spleen                                             (59)         (60)         (59)         (59)                                   
      Hemangiosarcoma                                               3 (5%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (53)         (57)         (50)         (52)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (59)                                   
      Mast Cell Tumor Benign                                                                  1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                               2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                       (1)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (100%)                              
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Adenoma                    14 (23%)      5 (8%)      12 (20%)     11 (19%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     4 (7%)      10 (17%)                               
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       6 (10%)      8 (13%)      9 (15%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                    3 (5%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                 1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       5 (8%)       3 (5%)       3 (5%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Nose                                               (59)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (26)         (31)         (33)         (36)                                   
      Adenoma                                          3 (12%)      6 (19%)     12 (36%)     12 (33%)                               
      Carcinoma                                        1 (4%)       1 (3%)       4 (12%)      3 (8%)                                
      Bilateral, Adenoma                                                         1 (3%)       9 (25%)                               
      Bilateral, Carcinoma                                                                    1 (3%)                                
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
      Renal Tubule, Adenoma                                                      3 (5%)       2 (3%)                                
   Urinary Bladder                                    (59)         (60)         (59)         (59)                                   
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(59)                                   
      Histiocytic Sarcoma                                           2 (3%)                                                          
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
      Lymphoma Malignant Mixed                         2 (3%)       2 (3%)       6 (10%)      3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05103-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:06:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.0312%      0.0625%      0.125%                                    
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          47          51          53                                       
     Total Primary Neoplasms                           63          90          92         116                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          33          44          49                                       
     Total Benign Neoplasms                            42          47          56          77                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          32          24          33                                       
     Total Malignant Neoplasms                         21          43          36          39                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           6           4           7                                       
     Total Metastatic Neoplasm                          5          11           4          19                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.