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TDMS Study 05103-04 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL


NTP Experiment-Test: 05103-04                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 05/13/94
Route: DOSED FEED                                                                                                 Time: 14:35:48


                                                           CORE STUDY


       Facility:  Southern Research Institute

       Chemical CAS #:  3296-90-0

       Lock Date:  02/12/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25023 Missing
                               25009 Missing                           25019 Moribund Sacrifice
                               25020 Natural Death                     25006 Terminal Sacrifice
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    UNTREATD CONTROL
                               Include 004    0.0312%
                               Include 006    0.0625%
                               Include 008    0.125%
                               Include 001    UNTREATD CONTROL
                               Include 003    0.0312%
                               Include 005    0.0625%
                               Include 007    0.125%























                                                             Page   1
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|             
                                           | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    3                    2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Degeneration, Fatty                  |                                        1                                 |             
      Developmental Malformation           |                                                       X                  |             
      Eosinophilic Focus                   |          X                                               3           2   |             
      Hematopoietic Cell Proliferation     |    2                                      4  4     2  4     3           4|             
      Hyperplasia, Lymphoid                |                            2                          2           2      |             
      Inflammation, Subacute               |                1     2                                               1   |             
      Mixed Cell Focus                     |                                                                          |             
      Kupffer Cell, Hyperplasia            |                                           4  4     3        4           4|             
      Kupffer Cell, Pigmentation           |                      1                                            2      |             
      Lobules, Necrosis                    |                               1                                   3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                    +               |             
      Fat, Necrosis                        |                                     3                    2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          4               |             
      Cyst                                 |                                                          X               |             
      Acinar Cell, Cytoplasmic Alteration  |                                        4     4                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                             2                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                              2                           |             
      Mucosa, Hyperplasia                  |                                        1     3  1                    2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Edema                                |    2                                                                     |             
      Erosion                              |                                              2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|             
                                           | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  X                 X     X               |             
      Hematopoietic Cell Proliferation     |                                           2                 2            |             
      Hypertrophy, Focal                   |                                                                2         |             
      Capsule, Hyperplasia                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                    2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         3                                         3      |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia, Focal    |          3        3           2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                3        1                    2  2        1  1            |             
      Follicle, Cyst                       |             X                                                            |             
      Follicular Cell, Hyperplasia         |       2     2  1     2                                2  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |          2                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                2        3     3         |             
      Cyst                                 |       X     X  X                          X           X                  |             
      Inflammation, Suppurative            |    4                                      4  4     4        4           4|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |       2     3                 4                       3           4      |             
      Hyperplasia, Cystic                  |    2  3  3  3  2  3  3  3  3  3  2  3  3  2  1  3  1     3  2  3  3  2  1|             
      Inflammation, Suppurative            | 2  2        2                             3                 2  1        2|             
      Metaplasia, Squamous                 |    3                                                        2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|             
                                           | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |    2        3     2                       4  3     2  4     2           2|             
      Myelofibrosis                        | 2           3     2           2                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                      +  +     +        +           +|             
      Bronchial, Hyperplasia, Lymphoid     |                                           4                              |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                              3                           |             
      Iliac, Hyperplasia, Lymphoid         |    3                                      4  3     3                    3|             
      Mediastinal, Hyperplasia, Lymphoid   |                                              4                           |             
      Renal, Hyperplasia, Lymphoid         |    3                                      4        4        4           4|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Hyperplasia, Lymphoid                |                   3                          3                          3|             
      Pigmentation                         |                                        2        3     2                 3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2  3                           |             
      Hemorrhage                           |          2                                   1                       1   |             
      Hyperplasia, Lymphoid                |                   2  3                    2  2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                              +                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4                 2     3              4  4  2  4  4     4     2  3  4|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Pigmentation, Hemosiderin            |                                        2        3                        |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |          2                                                     2  2      |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Atrophy                              |                                                    3                     |             
      Ectopic Parathyroid Gland            |                         X                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                3                                                         |             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 0| 4| 8| 4| 4| 4| 4| 4| 4| 7|             
                                           | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 1| 5| 3| 4| 3| 3| 8| 3| 3| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                        +                                 |             
      Atrophy                              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                         1|             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Infiltration Cellular, Histiocyte    |                                              3                           |             
      Inflammation, Subacute               |                                                    2                     |             
      Thrombosis                           |                                                    1                     |             
      Alveolar Epithelium, Hyperplasia     |                            1                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +           +              +  +  +     +     +     +      |             
      Hyperplasia                          |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        | 1  1  1  1        1     1              1  1        1                    1|             
      Cyst                                 |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Hyperplasia, Lymphoid                |          2  2                          2                       2         |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Renal Tubule, Atrophy                |                                                 2                        |             
      Renal Tubule, Cytoplasmic Alteration |                                              2                           |             
      Renal Tubule, Dilatation             |                         1                                                |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |                1        1                 2                          1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         3|             
      Hyperplasia, Lymphoid                |                                                       2        2         |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|             
                                           | 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                2                                                         |             
      Degeneration, Fatty                  |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                                       1                  |             
      Hematopoietic Cell Proliferation     |    4                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |                                                 2              1         |             
      Mixed Cell Focus                     |                                                                      4   |             
      Kupffer Cell, Hyperplasia            |                                                             2            |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |                                                             1           4|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                    +                              |             
      Fat, Necrosis                        |                      3                    4                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |    3                                               3                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    3                                      2                              |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                      2                 2           2                     |             
      Mucosa, Hyperplasia                  |    1                 3                 2           2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                  X                                       |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          3               |             
      Inflammation, Subacute               |                2                                2                        |             
      Mucosa, Hyperplasia                  |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|             
                                           | 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |                      3                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X                                   2                              |             
      Hematopoietic Cell Proliferation     |    3                                                                     |             
      Hypertrophy, Focal                   |                                              2                           |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4                     |             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                             X  X         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      2                                                   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |             3  2     2                                      2  3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2           1                 1  1  1  2                              |             
      Follicle, Cyst                       |                            X                                      X      |             
      Follicular Cell, Hyperplasia         |             1     1           1        3                    1        1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        2                    2              4                    2      |             
      Cyst                                 |                   X        X        X     X                 X            |             
      Inflammation, Suppurative            |    4                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                      4            |             
      Hydrometra                           |       3     3        3                                   3           3   |             
      Hyperplasia, Cystic                  | 3  3  3  3  4  3  2  2     2  3     3  3  2  4  3     2  2  3  4  3  2  2|             
      Inflammation, Suppurative            |    2     1                                                               |             
      Metaplasia, Squamous                 |    3        2                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|             
                                           | 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |    4                                               2        2            |             
      Myelofibrosis                        |                            3     2                             1         |             
      Necrosis                             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                             +                                       |             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |    4                                                                     |             
      Mediastinal, Hyperplasia, Lymphoid   |    3                                                                     |             
      Renal, Hyperplasia, Lymphoid         |    4                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |    4                 2                                                   |             
      Pigmentation                         |                                           2                       2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                    3                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                1         |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4        3        3        2  2              3           4            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                         2                                                |             
      Lymphoid Follicle, Atrophy           |                                                    3                     |             
      Lymphoid Follicle, Hyperplasia       |       3     2                 3                       2  3               |             
      Red Pulp, Atrophy                    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia, Lobular                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 2|             
                                           | 0| 6| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hyperostosis                         |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3                                                |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +     +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                           2  2                           |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                     1                                2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                +     +        +  +  +        +      |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |    3                 1  1                    1              1  1  1      |             
      Cyst                                 |                      X                                                   |             
      Glomerulosclerosis                   |    3                                                                     |             
      Hyperplasia, Lymphoid                |    2  2                       2     2        2                           |             
      Metaplasia, Osseous                  |                                                          2               |             
      Mineralization                       |                                                    4                     |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Dilatation             |    3                                               2                     |             
      Renal Tubule, Pigmentation           |                                                             3            |             
      Renal Tubule, Regeneration           |    4                 1                                         1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mucosa, Hyperplasia                  |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    UNTREATD                               | 9| 9|                                                                    |      L     |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A                                                                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                                                                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +                                                                     |  52        |
      Edema                                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A                                                                     |  51        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A                                                                     |  49        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A                                                                     |  51        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      4  2.0|
      Hematopoietic Cell Proliferation     | 3                                                                        |      9  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Inflammation, Subacute               |                                                                          |      5  1.4|
      Mixed Cell Focus                     |                                                                          |      1  4.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      6  3.5|
      Kupffer Cell, Pigmentation           |                                                                          |      2  1.5|
      Lobules, Necrosis                    |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A                                                                     |  51        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      4  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A                                                                     |  51        |
      Ulcer                                | 2                                                                        |      5  2.0|
      Mucosa, Hyperplasia                  | 3                                                                        |      9  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A                                                                     |  51        |
      Ectopic Tissue                       |                                                                          |      1     |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    UNTREATD                               | 9| 9|                                                                    |      L     |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               | 3                                                                        |      3  2.3|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |  52        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  A                                                                     |  51        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      5  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Hypertrophy, Focal                   |                                                                          |      2  2.0|
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  A                                                                     |  51        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A                                                                     |  51        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  A                                                                     |  44        |
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A                                                                     |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.7|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A                                                                     |  51        |
      Degeneration, Cystic                 |                                                                          |     12  1.5|
      Follicle, Cyst                       |                                                                          |      3     |
      Follicular Cell, Hyperplasia         |                                                                          |     13  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +                                                                     |  52        |
      Ectasia                              | 3  3                                                                     |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +                                                                     |  51        |
      Angiectasis                          |                                                                          |      9  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    UNTREATD                               | 9| 9|                                                                    |      L     |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |     10     |
      Inflammation, Suppurative            |    4                                                                     |      8  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +                                                                     |  52        |
      Angiectasis                          |                                                                          |      2  3.0|
      Hydrometra                           |                                                                          |     10  3.1|
      Hyperplasia, Cystic                  | 1                                                                        |     46  2.6|
      Inflammation, Suppurative            |                                                                          |      9  1.9|
      Metaplasia, Squamous                 |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |  52        |
      Hypercellularity                     | 3                                                                        |     13  2.7|
      Myelofibrosis                        |                                                                          |      7  2.1|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   9        |
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  4.0|
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      6  3.3|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  3.5|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      6  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  A                                                                     |  48        |
      Atrophy                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  3.0|
      Pigmentation                         |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  A                                                                     |  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      4  1.3|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A                                                                     |  51        |
      Hematopoietic Cell Proliferation     | 4                                                                        |     20  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      3  2.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    UNTREATD                               | 9| 9|                                                                    |      L     |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoid Follicle, Hyperplasia       |                                                                          |      8  2.4|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  A                                                                     |  46        |
      Atrophy                              |                                                                          |      2  3.0|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                                                                     |  52        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Hyperplasia, Lobular                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |  52        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |  52        |
      Hyperostosis                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |  52        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |  52        |
      Hemorrhage                           |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |  52        |
      Exudate                              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A                                                                     |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +                                                                     |  18        |
      Hyperplasia                          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4|                                                                    |            |
                             DAY ON TEST   | 8| 0|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    UNTREATD                               | 9| 9|                                                                    |      L     |
     CONTROL                               | 4| 8|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  A                                                                     |  51        |
      Casts Protein                        |                                                                          |     17  1.1|
      Cyst                                 |                                                                          |      1     |
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      9  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Renal Tubule, Atrophy                |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |                                                                          |      3  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           |                                                                          |      7  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A                                                                     |  51        |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          1               |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                           3                              |             
      Hematopoietic Cell Proliferation     |                                                          2  3            |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Inflammation, Subacute               |                                                                1         |             
      Mixed Cell Focus                     |             3                                                            |             
      Centrilobular, Necrosis              |       3                                                                  |             
      Kupffer Cell, Hyperplasia            |                                                          3               |             
      Lobules, Necrosis                    | 1        3                             1                    4            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +  +                    +  +|             
      Fat, Necrosis                        |                                              3                       3  3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                     4   |             
      Cyst                                 |                                                                      X   |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Acinar Cell, Cytoplasmic Alteration  |                               3                             4            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2                          2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |          2                                                               |             
      Ulcer                                |                                                    2                     |             
      Mucosa, Hyperplasia                  |                         2                          2                    3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                      2   |             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | X                          X                                            X|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                   X               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                2  3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |          2  2              1                    2     2                  |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |             1  1        3           1  2  1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2     2                                 |             
      Cyst                                 |                            X     X           X                    X      |             
      Inflammation, Suppurative            |                                                          4               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       4                                                        2         |             
      Hydrometra                           |    2        4                                                            |             
      Hyperplasia, Cystic                  | 2     2  1     3  3  2  4  2     3  3  2  3  2  2  2  3  2  2  3  3      |             
      Inflammation, Suppurative            |                   2                                                      |             
      Metaplasia, Squamous                 |             2        2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |       2        3     3                    2              3  3            |             
      Myelofibrosis                        |                3     2  2           2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +     +                                +        +               |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Pancreatic, Necrosis                 |          4                                                               |             
      Renal, Hyperplasia, Lymphoid         |    3                                                     4               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |             2        3                                3                  |             
      Pigmentation                         |                                                          3  2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                                                   |             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Hemorrhage                           |                         2        1                                   2   |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |          +                                      +                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  4        2  2  3  1     3     3     3        1     4  4  2         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                   2     2                                                |             
      Lymphoid Follicle, Hyperplasia       |             2                          2  3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                      3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          1                                                               |             
      Hyperplasia, Lobular                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Subacute               |                                              3                           |             
      Inflammation, Suppurative            |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 3| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 6| 9| 8| 4| 4| 4| 3| 4| 7| 0| 4| 6| 4| 4| 5| 1| 4| 4| 3| 7| 4| 4| 7| 4|             
                                           | 3| 8| 2| 6| 3| 3| 3| 5| 3| 7| 6| 3| 9| 3| 3| 5| 3| 3| 3| 0| 9| 3| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0312%                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Lymphoid                |    2        3  2           2                                             |             
      Infiltration Cellular, Histiocyte    |                      2                    2                              |             
      Inflammation, Subacute               |                                                                          |             
      Thrombosis                           |                                                          X           X   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Cataract                             |                   2                                                      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +     +     +  +  +        +  +        +     +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |    2     1        1           2     1              1  1     1        1   |             
      Glomerulosclerosis                   |                                                                          |             
      Hyperplasia, Lymphoid                |    2        2           2     2                                          |             
      Metaplasia, Osseous                  |                                           2                              |             
      Renal Tubule, Cytoplasmic Alteration |                                                             3            |             
      Renal Tubule, Dilatation             |                               1                                          |             
      Renal Tubule, Regeneration           | 1  3                          3     1  1  1     1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    3                                                     2               |      3  2.0|
      Clear Cell Focus                     |       1                                                                  |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                4           3  2                    4                     |      6  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                      1   |      2  1.0|
      Mixed Cell Focus                     |                                                    2                     |      2  2.5|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Kupffer Cell, Hyperplasia            |                3     2     3                                             |      4  2.8|
      Lobules, Necrosis                    |                   1                                3           3         |      7  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                            +                     |   6        |
      Fat, Necrosis                        |       4                                            4                     |      5  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      4                                                   |      3  3.7|
      Cyst                                 |                      X                                                   |      2     |
      Hyperplasia, Lymphoid                |                                                                      2   |      2  2.0|
      Acinar Cell, Cytoplasmic Alteration  |                3                                                         |      3  3.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                        2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                2         |      2  2.0|
      Mucosa, Hyperplasia                  | 2                                                              2         |      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                   2      |      1  2.0|
      Mucosa, Hyperplasia                  |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                   +      |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                         X           X                                   X|      6     |
      Angiectasis                          |                                                          3               |      1  3.0|
      Cyst                                 |                X                                         X               |      2     |
      Degeneration, Fatty                  |                               3                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                2           3                                             |      2  2.5|
      Hypertrophy, Focal                   |          2                                                               |      1  2.0|
      Capsule, Hyperplasia                 |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Cyst                                 |                X                                                  X      |      4     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                      2                                                  3|      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |                                                                   3     3|      4  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                            2                                             |      6  1.8|
      Follicle, Cyst                       |                                              X        X           X      |      3     |
      Follicular Cell, Hyperplasia         | 4  3                          4           1  2  1     2  1           2   |     15  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +              +                              |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |             2                             3                    2         |      5  2.2|
      Cyst                                 |    X                             X  X           X  X        X  X        X|     12     |
      Inflammation, Suppurative            |                4                                                         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |          2  2  4                                         3               |      6  2.8|
      Hydrometra                           |                         3                          4                 3   |      5  3.2|
      Hyperplasia, Cystic                  |    3  3  3  2     2  3  2  2  3  3     3  3  4  3     1  2  2  3  2  2  2|     41  2.5|
      Inflammation, Suppurative            |                2                                                         |      2  2.0|
      Metaplasia, Squamous                 |                         3                                                |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                4  3     2  3  2           3        2           3  2      |     15  2.7|
      Myelofibrosis                        |                                                 2                        |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +     +  +           +        +           +         |  12        |
      Iliac, Hyperplasia, Lymphoid         |                               2                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                               2                                          |      1  2.0|
      Pancreatic, Necrosis                 |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
      Hyperplasia, Lymphoid                |                2              2                       3                  |      6  2.5|
      Pigmentation                         |                               2     2                       2            |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |             1                                                            |      4  1.5|
      Hyperplasia, Lymphoid                |                               2              2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                            +              +        +           +         |   6        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2           2  4        2  4  3           2     3  3     2     2     2   |     25  2.6|
      Hyperplasia, Lymphoid                |                                  2                          3            |      2  2.5|
      Pigmentation, Hemosiderin            |                         2                                                |      3  2.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                               3                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                2                                            2            |      3  1.7|
      Hyperplasia, Lobular                 |                                                          2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |             1                                                            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | X                             X                          X  X            |      4     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           3                              |      1  3.0|
      Foreign Body                         |                                                                   2      |      1  2.0|
      Hemorrhage                           |                3                                                         |      2  2.5|
      Hyperplasia, Lymphoid                |                         2                                                |      5  2.2|
      Infiltration Cellular, Histiocyte    |             4                                1                 1         |      5  2.0|
      Inflammation, Subacute               |                                                                   3      |      1  3.0|
      Thrombosis                           |                                  X                                       |      3     |
      Alveolar Epithelium, Hyperplasia     |                      1                    2  1                           |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                +         |   2        |
      Cataract                             |                                                                3         |      2  2.5|
      Inflammation, Chronic                |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +     +                 +  +  +     +     +        +     +         |  27        |
      Hyperplasia                          |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts Protein                        |             2           1  1  1  1     2        1        1               |     17  1.2|
      Glomerulosclerosis                   |                                        3                                 |      1  3.0|
      Hyperplasia, Lymphoid                |          3           2                 3                          2  2   |      9  2.2|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 4| 2| 4| 0| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4|            |
                                           | 7| 3| 3| 3| 3| 1| 9| 3| 3| 5| 6| 3| 7| 3| 8| 3| 3| 4| 4| 4| 4| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0312%                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Dilatation             |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |          1                       1     3                                 |     10  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |          2                                                               |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Edema                                |                2                       2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    1                                      4                              |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |             2                                                            |             
      Hematopoietic Cell Proliferation     |                         4                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |    2                                                     3               |             
      Mixed Cell Focus                     |                                                             3            |             
      Centrilobular, Necrosis              |                                                       2                  |             
      Kupffer Cell, Hyperplasia            | 2                 3     4                                   3            |             
      Kupffer Cell, Pigmentation           |                                                             1            |             
      Lobules, Necrosis                    |                   3                    2     3                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                                   +        +|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                            4                                   3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             4                                               4            |             
      Cyst                                 |    X        X                                               X            |             
      Acinar Cell, Cytoplasmic Alteration  | 4                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                   2                 2            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                  2                                       |             
      Inflammation, Suppurative            |                                              2                           |             
      Ulcer                                | 1                                                                        |             
      Mucosa, Hyperplasia                  | 1  2        1              1                 2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                        3                                 |             
      Inflammation, Subacute               |                                                          1               |             
      Mineralization                       |                                                             3            |             
      Mucosa, Hyperplasia                  |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    2                     |             
      Mineralization                       |                                                             4            |             
      Thrombosis                           |                                                    X                     |             
      Myocardium, Necrosis                 |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                           X  X     X           2        X|             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hypertrophy, Focal                   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                       1                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                         2        2     1     2        2     2        1   |             
      Ectopic Thymus                       |                                           X                              |             
      Follicle, Cyst                       |                   X                                                      |             
      Follicular Cell, Hyperplasia         | 1              1              1           3           1        3     1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                         2|             
      Inflammation, Chronic                |                         2                                                |             
      Inflammation, Suppurative            | 3                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2        4                 2              4  3  2        2     3  2   |             
      Cyst                                 |                            X              X     X        X  X            |             
      Inflammation, Suppurative            |                   4     4                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          4                 3                    3     4  3           4   |             
      Hydrometra                           |                3                 3                             3         |             
      Hyperplasia, Cystic                  | 2  3  2  2  2  3  3     2  3  3  2     3  2  2  3  2  2  3  3  2  3  2   |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                         3                                2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     | 3        4  3           3     2     3  3     3     3  2              3   |             
      Myelofibrosis                        |                                                 2     2     2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +           +                             +                  |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                       2                  |             
      Mediastinal, Hyperplasia, Lymphoid   |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3     1              2                                         2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        3                                 |             
      Hematopoietic Cell Proliferation     |                               1                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |       3                                         2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +        +              +                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3           3  3  3     4     2     2  4  2  4        4  2           3   |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  I  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                         1|             
      Hyperplasia, Lobular                 |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         3                                                |             
      Inflammation, Subacute               |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                  3              2                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                 X                        |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 1| 4| 9| 3| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| 2| 4| 7| 1| 4| 0| 4| 4| 4| 9|             
                                           | 9| 9| 4| 3| 9| 4| 5| 4| 0| 4| 4| 4| 3| 4| 4| 6| 4| 5| 1| 4| 9| 4| 4| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0625%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                   2                             2                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    M                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                          +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                        1           3                     |             
      Hyperplasia, Lymphoid                |       2        2                 2                       2               |             
      Infiltration Cellular, Histiocyte    |    2                             2                       1               |             
      Inflammation, Subacute               |                   3                                                      |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       1        1                       2              2  1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                             2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +        +                                 |             
      Cataract                             |                                                                          |             
      Phthisis Bulbi                       |                               3        3                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +           +     +  +     +  +  +     +  +  +     +  +           +     +|             
      Hyperplasia                          |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |    1           1                             1     1  1     1     1      |             
      Cyst                                 |                X                                                         |             
      Hyperplasia, Lymphoid                |       2                                         4                        |             
      Metaplasia, Osseous                  |                            2                                             |             
      Mineralization                       |                                                          1  4            |             
      Renal Tubule, Cytoplasmic Alteration |                         2                    3                           |             
      Renal Tubule, Dilatation             |                                              3                           |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |                                                       2                  |             
      Renal Tubule, Regeneration           |    4                       1           1     3              2        1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             3            |             
      Hyperplasia, Lymphoid                |       2                 2                                                |             
      Inflammation, Subacute               |                                                 2           2            |             
      Mucosa, Hyperplasia                  |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                                            2                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                                                    X                     |             
      Degeneration, Fatty                  |                         1                                                |             
      Eosinophilic Focus                   | 2     3                                                                  |             
      Hematopoietic Cell Proliferation     |                      3              2                                2   |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |    3           2                                                         |             
      Centrilobular, Necrosis              |                                     3                                    |             
      Kupffer Cell, Hyperplasia            |                      4           3                                   2   |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |                                  1              1                       2|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +        +                                          |             
      Inflammation, Chronic                |                      4                                                   |             
      Fat, Necrosis                        |             2                 3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                             2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                | 2     2                 2                                         2      |             
      Mucosa, Hyperplasia                  | 2     2     2           3                                2  2     2     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
      Erosion                              |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |                                                                          |             
      Mucosa, Hyperplasia                  |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Myocardium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X                                             |             
      Degeneration, Fatty                  |                                                                      2   |             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             2  2                    2                                   2|             
      Pars Distalis, Cyst                  | X                                                                        |             
      Pars Distalis, Hyperplasia, Focal    |                                     1                 2     3           2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             2                 1     2           1        1           2   |             
      Ectopic Thymus                       |                                                                          |             
      Follicle, Cyst                       |                                           X                              |             
      Follicular Cell, Hyperplasia         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3     2                 2                       4        2  3     4  2   |             
      Cyst                                 |       X        X  X                                      X        X     X|             
      Inflammation, Suppurative            |                      4           4                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  4           3        2     2  3           4     3           3     3|             
      Hydrometra                           |          3     4                                   3     4               |             
      Hyperplasia, Cystic                  | 3  2  3  2  2  2  3  3        3  2  2  2     3  3     3  2  3  3  3  3  2|             
      Inflammation, Granulomatous          |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                   2  2           1                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |       3              2           2                          2            |             
      Myelofibrosis                        |       3     2                 2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                                                  |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2           2     3                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                   3                                                      |             
      Hyperplasia, Lymphoid                |                   2                                                     2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +                          +                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3  3        2  4  2  3     4  4           4           2        3  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                    2                 3   |             
      Lymphoid Follicle, Hyperplasia       | 2                       3                                3  2           3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3  3                 3   |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                3                                                         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      X   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 4| 6| 1| 4| 4| 4| 4| 2| 8| 5| 6| 3| 0| 4| 7| 4| 3| 5| 4| 4| 4| 4| 4| 3| 4|             
                                           | 4| 9| 8| 4| 4| 4| 4| 9| 3| 7| 9| 9| 7| 4| 9| 4| 3| 2| 4| 4| 4| 4| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0625%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           4                              |             
      Hemorrhage                           |                                                                2         |             
      Hyperplasia, Lymphoid                |                   2           2                                          |             
      Infiltration Cellular, Histiocyte    |    2                    4                                                |             
      Inflammation, Subacute               |                      2        2                                          |             
      Mineralization                       |                                                                2         |             
      Thrombosis                           |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |                                        1     1                    3      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cataract                             |    2                                                                     |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +        +  +     +     +  +     +  +        +     +  +        +      |             
      Hyperplasia                          |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |          1  1              2                 1     1                 1   |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |    2        2                                                           2|             
      Metaplasia, Osseous                  |                                                       2                  |             
      Mineralization                       |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Dilatation             |                                                                      2   |             
      Renal Tubule, Necrosis               |                                                 1                    2   |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           | 1  1     1                 2                                      1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      3                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia                  |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.0625%                                | 1|                                                                       |      L     |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A                                                                        |  47        |
      Dilatation                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A                                                                        |  49        |
      Edema                                |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  50        |
      Basophilic Focus                     |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      2  2.5|
      Mixed Cell Focus                     |                                                                          |      3  2.7|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
      Kupffer Cell, Hyperplasia            |                                                                          |      7  3.0|
      Kupffer Cell, Pigmentation           |                                                                          |      1  1.0|
      Lobules, Necrosis                    |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A                                                                        |  49        |
      Atrophy                              |                                                                          |      2  4.0|
      Cyst                                 |                                                                          |      3     |
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Diverticulum                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  1.8|
      Mucosa, Hyperplasia                  |                                                                          |     13  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  49        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.0625%                                | 1|                                                                       |      L     |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
      Myocardium, Necrosis                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      6  2.0|
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  49        |
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  48        |
      Pars Distalis, Angiectasis           |                                                                          |      5  1.8|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Degeneration, Cystic                 |                                                                          |     13  1.6|
      Ectopic Thymus                       |                                                                          |      1     |
      Follicle, Cyst                       |                                                                          |      2     |
      Follicular Cell, Hyperplasia         |                                                                          |      9  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  51        |
      Ectasia                              | 2                                                                        |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.0625%                                | 1|                                                                       |      L     |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |     17  2.7|
      Cyst                                 |                                                                          |     11     |
      Inflammation, Suppurative            |                                                                          |      4  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Angiectasis                          |                                                                          |     16  3.1|
      Hydrometra                           |                                                                          |      7  3.3|
      Hyperplasia, Cystic                  |                                                                          |     43  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hypercellularity                     |                                                                          |     15  2.7|
      Myelofibrosis                        |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      8  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M                                                                        |  46        |
      Angiectasis                          |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |     25  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  2.5|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  46        |
      Atrophy                              |                                                                          |      4  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.0625%                                | 1|                                                                       |      L     |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                                                                          |      1  1.0|
      Hyperplasia, Lobular                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Hyperostosis                         |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Compression                          |                                                                          |      2     |
      Hemorrhage                           | 2                                                                        |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Necrosis                             | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      5  2.2|
      Inflammation, Subacute               |                                                                          |      3  2.3|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      8  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Exudate                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      1  2.0|
      Phthisis Bulbi                       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  27        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    0.0625%                                | 1|                                                                       |      L     |
                                           | 3|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Casts Protein                        |                                                                          |     13  1.1|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.4|
      Metaplasia, Osseous                  |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      2  2.5|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      2  2.5|
      Renal Tubule, Necrosis               |                                                                          |      2  1.5|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                          |     11  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Edema                                |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Subacute               |                                                                          |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                 2                 2      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             1            |             
      Degeneration, Fatty                  |                                  1        2     2                        |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                  2                                1      |             
      Hematopoietic Cell Proliferation     |    2  2     4     4                 2     2  2  3        4        2      |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Inflammation, Subacute               |             4                                                            |             
      Mixed Cell Focus                     |             4                                                            |             
      Centrilobular, Necrosis              |                         4                                               3|             
      Kupffer Cell, Hyperplasia            |          2  3     3  3                             2        2            |             
      Kupffer Cell, Pigmentation           |                                                    3                     |             
      Lobules, Necrosis                    |             3                    3                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +           +     +        +     +                        |             
      Fat, Necrosis                        |                3           3              4     4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4                                         3     3                    4   |             
      Cyst                                 | X                                         X     X                    X   |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                2                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                 2                        |             
      Mucosa, Hyperkeratosis               |                                        3                                 |             
      Mucosa, Hyperplasia                  |             2              1                    2                       2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            2                                             |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                         4                                                |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X                                                                     |             
      Hematopoietic Cell Proliferation     |             3     2                                                      |             
      Hyperplasia, Focal                   |                                                          3               |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Angiectasis           |                                                       2                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                   1  2                                2        2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             2                 2     2        2     3  1  2               |             
      Follicle, Cyst                       |                                  X                                       |             
      Follicular Cell, Hyperplasia         |                      2                 1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                          3               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2     3  3  3  2  3                                       |             
      Cyst                                 |                   X  X  X              X     X        X        X  X      |             
      Inflammation, Suppurative            |             4                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    4        2        2                    2  4  3     2     4  3     2  4|             
      Hydrometra                           |                                                             2           3|             
      Hyperplasia, Cystic                  |    1  2  2  2  3  3  3  1     2  3  2  2  2  2  2  3  3  3     4  2  3   |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |    3  3     4     4                 3  2  4  3  4  2     4  3  4  2     3|             
      Myelofibrosis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +        +                                             |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |             4                                                            |             
      Mediastinal, Hyperplasia, Lymphoid   |             4                                                            |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                   4                                                      |             
      Pancreatic, Hyperplasia, Lymphoid    |                   3                                                      |             
      Renal, Hyperplasia, Lymphoid         |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
      Hemorrhage                           |          3              1                                                |             
      Hyperplasia, Lymphoid                | 3           4     3                 2                             3      |             
      Pigmentation                         |          2              3                 2                             2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1                 3                                                      |             
      Hemorrhage                           | 1                                                                        |             
      Hyperplasia, Lymphoid                |             2     3                                   3                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  3  3  4  1  4  3  4     2  3  3  3  3  4  4  3     4  4  3  3     4|             
      Hemorrhage                           |          3                                                               |             
      Pigmentation, Hemosiderin            |                                                    3                     |             
      Lymphoid Follicle, Hyperplasia       |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  M  +  M  +  +  +  I  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                   3           3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  3                                       |             
      Inflammation, Suppurative            |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 5| 5| 6| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 5| 5| 7| 4| 4| 5| 6| 6| 4|             
                             DAY ON TEST   | 6| 4| 7| 3| 7| 0| 7| 3| 1| 4| 6| 7| 1| 4| 5| 6| 3| 3| 4| 5| 8| 2| 5| 6| 9|             
                                           | 9| 9| 2| 7| 5| 6| 6| 3| 0| 4| 9| 4| 9| 2| 4| 8| 4| 4| 4| 6| 3| 0| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.125%                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |          3                                                               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 3                                   2                          1         |             
      Inflammation, Subacute               |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          2     3     2     3     2     2                             3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                    +   |             
      Cataract                             |                                                                      2   |             
      Inflammation, Chronic                |                                                                          |             
      Phthisis Bulbi                       | X                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +        +  +  +        +  +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Lymphoid                |                   2                                3                     |             
      Metaplasia, Osseous                  |       2                                                                  |             
      Mineralization                       |                                                                          |             
      Renal Tubule, Dilatation             |                                           2                              |             
      Renal Tubule, Necrosis               |                         3                                                |             
      Renal Tubule, Pigmentation           |                                              2                           |             
      Renal Tubule, Regeneration           |                                        1  3  1  4  2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  I|  45        |
      Dilatation                           |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                   2           2                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                         3|      2  2.0|
      Degeneration, Fatty                  |                                                                          |      3  1.7|
      Developmental Malformation           |                                                    X                     |      1     |
      Eosinophilic Focus                   |                      2                                         2        2|      5  1.8|
      Hematopoietic Cell Proliferation     |    2                             3           2  1     2                  |     15  2.5|
      Hyperplasia, Lymphoid                |                                                                         2|      2  2.0|
      Inflammation, Subacute               |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                                                                          |      1  4.0|
      Centrilobular, Necrosis              |                                                                          |      2  3.5|
      Kupffer Cell, Hyperplasia            |    2                          2  3           3        3        2         |     12  2.5|
      Kupffer Cell, Pigmentation           |                                                                          |      1  3.0|
      Lobules, Necrosis                    |                3                             1                    1     1|      6  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   6        |
      Fat, Necrosis                        |          3                                                               |      5  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                     4                                    |      5  3.6|
      Cyst                                 |                                     X                                    |      5     |
      Focal Cellular Change                |                   2           2                    2                    2|      4  2.0|
      Hyperplasia, Lymphoid                |                                                                2         |      2  2.5|
      Acinar Cell, Cytoplasmic Alteration  |                                              3     3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                     2                          2         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                    1                     |      1  1.0|
      Ulcer                                |                                        2                          2      |      3  2.0|
      Mucosa, Hyperkeratosis               |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                        3                          2      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                       2                  |      2  2.0|
      Mineralization                       |                            2                                             |      1  2.0|
      Ulcer                                |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
      Mineralization                       |                                                                          |      1  4.0|
      Thrombosis                           |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |       X                    X                                            2|      4  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Hypertrophy, Focal                   |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2                                                     2     2|      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                X         |      1     |
      Pars Distalis, Hyperplasia, Focal    |       1           2           1                             1            |      8  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 | 2  1           2  2     2                          1        1            |     14  1.8|
      Follicle, Cyst                       |                                              X                           |      2     |
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |       2        4     3                          2                    3   |     11  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |       X                 X  X           X           X        X  X        X|     16     |
      Inflammation, Suppurative            |    4     3                       4        4           4                  |      6  3.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 4  4           2        4                          4                 1   |     17  3.0|
      Hydrometra                           |                                                    3     3               |      4  2.8|
      Hyperplasia, Cystic                  | 3  3  3  2  2  2  2  3  2  2  2  3  2  2  2  2  2  2     3  2  2  2  3  2|     45  2.3|
      Inflammation, Granulomatous          |                               3                                          |      1  3.0|
      Inflammation, Suppurative            |    3                                                                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |    4     2  3  3        2        3        3  3  2     2                  |     25  3.0|
      Myelofibrosis                        |                2        2  2  2                                2  2      |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +           +              +  +        +                  |   9        |
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |    3                                                                     |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |    3                                                  3                  |      3  3.3|
      Mediastinal, Hyperplasia, Lymphoid   |                            2                          3                  |      3  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                       3                  |      1  3.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |    4                       4              4           3                  |      5  3.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     |    2                                                                     |      2  2.5|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                   3     2  2        2        3                 4         |     11  2.8|
      Pigmentation                         |    3                    2                       2                        |      7  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                2                                                         |      3  2.0|
      Hemorrhage                           |             4                                               1        1   |      4  1.8|
      Hyperplasia, Lymphoid                |                   2     2              2     3     3           3         |      9  2.6|
      Pigmentation                         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                            +                          +                  |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  4     2  3  4  2     3  2     3        4  3  3     4  3  1  4  2     3|     39  3.1|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                      2                                            2      |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoid Follicle, Hyperplasia       |                         3  3                                   3         |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  42        |
      Atrophy                              |                                                       3                  |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Hyperplasia, Cystic                  |                                              3        1                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                         2                                         2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                   2                                                      |      1  2.0|
      Hemorrhage                           |          2                                   1                           |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                2         |      1  2.0|
      Infiltration Cellular, Histiocyte    |                   2                                               2      |      5  2.0|
      Inflammation, Subacute               |                                  3        3                              |      2  3.0|
      Thrombosis                           |          X                                                               |      1     |
      Alveolar Epithelium, Hyperplasia     | 2  1  2     1              1           1                 1        3      |     15  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +              +  +  +                                          |   7        |
      Cataract                             |                         2                                                |      2  2.0|
      Inflammation, Chronic                |       3  3              3  3  2                                          |      5  2.8|
      Phthisis Bulbi                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +     +  +     +  +  +        +           +  +  +  +  +  +     +|  33        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 4| 5| 4| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 6| 5| 6| 4| 6| 4| 4| 4| 6| 0| 4| 4| 2| 5| 8| 8| 0| 1| 4| 4| 4| 4| 4|            |
                                           | 7| 7| 9| 1| 7| 4| 9| 4| 4| 9| 9| 2| 4| 4| 6| 1| 0| 6| 1| 5| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.125%                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Casts Protein                        |       1  1                                               1              1|      4  1.0|
      Hydronephrosis                       |                            3                                             |      1  3.0|
      Hyperplasia, Lymphoid                |                            3                                   4         |      4  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                                     1                                    |      1  1.0|
      Renal Tubule, Dilatation             |                            3                                             |      2  2.5|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                         2|      6  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |             2                                                            |      1  2.0|
      Hyperplasia, Lymphoid                |                            2                                      2      |      3  2.0|
      Inflammation, Subacute               |             2                                                            |      1  2.0|
      Mucosa, Hyperplasia                  |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|             
                                           | 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                3                                                         |             
      Clear Cell Focus                     |                            2  3     3  2                 4               |             
      Eosinophilic Focus                   |                                           2        2                     |             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Inflammation, Subacute               |                         1                                                |             
      Mixed Cell Focus                     |                                                             X        3   |             
      Kupffer Cell, Hyperplasia            |                                                                         3|             
      Kupffer Cell, Pigmentation           |                                                                         2|             
      Lobules, Necrosis                    |          3                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Fat, Necrosis                        |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                             |             
      Cyst                                 |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                                                    4                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                    2              1      |             
      Mucosa, Hyperplasia                  |                                                    2     2        1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                2         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                 +  +                 +        +      |             
      Dysplasia                            |                   3                 2  2                 2        2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              X              X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|             
                                           | 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   | 2                                1        1           2  2  1  1         |             
      Capsule, Hyperplasia                 |    2                          2        2                    2            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2     2     2           3        4  2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                  3     2                 1  1            |             
      Follicle, Cyst                       |                X                                                         |             
      Follicular Cell, Hyperplasia         |    1           1        2                 1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
      Cyst                                 |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                    +                     |             
      Dilatation                           |                                                    4                     |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                    X                     |             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  3                 3                     |             
      Ectasia                              | 3                 3  3  3           3        3              3  4  2     3|             
      Inflammation, Chronic                |             2     3     4  3     3           4     2     4           2   |             
      Inflammation, Suppurative            |                      2              3                    4               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    3                    3           3              4     3  3     3      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |    3        2                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                    1                    2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                  3        2                             2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +  +                                    |             
      Inguinal, Hyperplasia, Lymphoid      |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|             
                                           | 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Pigmentation               |                                  2                                       |             
      Renal, Hemorrhage                    |                                     1                                    |             
      Renal, Hyperplasia, Lymphoid         |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  A  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                            2              2           2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   1        1     1  3  2  1     2  3  2        1     2   |             
      Hyperplasia, Lymphoid                |             2                       2           3                        |             
      Pigmentation                         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             3                             3                             4|             
      Lymphoid Follicle, Atrophy           |                                                    3                     |             
      Lymphoid Follicle, Hyperplasia       |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2     2                           |             
      Infiltration Cellular, Histiocyte    |                                        3  2  2  2                        |             
      Thrombosis                           | X                                                                        |             
      Alveolar Epithelium, Hyperplasia     | 2                                            2           1           2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
      Foreign Body                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +        +     +     +  +  +                 +     +           +     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 7|             
                                           | 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     CONTROL                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Casts Protein                        |    1        1        1                    2                             3|             
      Cyst                                 |                      X        X        X  X           X        X         |             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       | 2  3           1  2  2  3  2  2  1  3  1        2  2     2  2     3  1   |             
      Renal Tubule, Atrophy                |                                           1                              |             
      Renal Tubule, Dilatation             |                                                 1                    1   |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Regeneration           | 2  1     1  2  1  1  1  1  1  2  1  1  2  2  2  2  1  1  2  2  1  2  1  3|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
      Concretion                           |                                                    3                     |             
      Inflammation, Subacute               |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                    3                     |             
      Hyperplasia, Lymphoid                |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |    2                                   2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Peyer's Patch, Hyperplasia           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |    2                          3                                          |      3  2.7|
      Clear Cell Focus                     |          2                                                               |      6  2.7|
      Eosinophilic Focus                   |          3           3                                                   |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Subacute               |          2                 1                                             |      3  1.3|
      Mixed Cell Focus                     |          3                             2                       2         |      5  2.5|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           |                                                                          |      1  2.0|
      Lobules, Necrosis                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                   +     +|   3        |
      Fat, Necrosis                        |                                                                   2     3|      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                      X                                                   |      1     |
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      2  1.5|
      Mucosa, Hyperplasia                  |                                                                      1   |      4  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +        +        +                          +           +  +     +  +|  13        |
      Dysplasia                            |    3        2        3                          2           2  3     2  2|     13  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2     |
      Hyperplasia, Focal                   |                                     2        3              2            |      3  2.3|
      Hypertrophy, Focal                   |                   1                 2              1  2  3  2     1      |     14  1.6|
      Capsule, Hyperplasia                 |                                                                3         |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 3  3        3        3  2                          4        4  3         |     14  2.9|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                  X                                       |      2     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                     1                    3     2     2   |      8  1.9|
      Follicle, Cyst                       |                                     X                                    |      2     |
      Follicular Cell, Hyperplasia         |                   1                 1                                    |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |    +                                                                     |   2        |
      Dilatation                           |    3                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hypospermia                          |                                                                          |      1     |
      Spermatocele                         |                                                          X               |      1     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      2  3.0|
      Ectasia                              |    3  3     2     2  2  2  4  3     2     3        2     2        2  3   |     24  2.7|
      Inflammation, Chronic                | 2  3  2  3  4        4  3           4  2     2     2     2     3         |     22  2.9|
      Inflammation, Suppurative            |                      3  2  2  2                                3         |      8  2.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           | 4  4        3        4              3           3           3  4         |     15  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |    3                                                        2            |      2  2.5|
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Seminiferous Tubule, Atrophy         |                            2                                             |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hypercellularity                     |                                                                      3   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |   3        |
      Inguinal, Hyperplasia, Lymphoid      |                      2                                                   |      2  2.0|
      Inguinal, Pigmentation               |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                                     2                                    |      1  2.0|
      Pigmentation                         |                   2     2              2                                 |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |    2     2           2              3        1  3                        |     17  1.9|
      Hyperplasia, Lymphoid                |                                        2                                 |      4  2.3|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                         2     3  2     1                             2   |      8  2.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia, Lymphoid                |                                     4                                    |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 9| 6| 6| 6| 6| 6| 4| 6| 9| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     CONTROL                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                            1                                             |      1  1.0|
      Hyperplasia, Lymphoid                |                   1                                                      |      3  1.7|
      Infiltration Cellular, Histiocyte    |    3                    2                                                |      6  2.3|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                          1           1   |      6  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Exudate                              |    2                                                                     |      1  2.0|
      Foreign Body                         |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +  +  +  +  +     +     +  +     +                 +            |  22        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Casts Protein                        |                                  1                                       |      6  1.5|
      Cyst                                 |             X        X                          X     X     X           X|     12     |
      Hyperplasia, Lymphoid                |                2                                                        2|      3  2.0|
      Metaplasia, Osseous                  | 2                                                                        |      1  2.0|
      Mineralization                       | 3  2     2  1  2  2  3     2     2  2  1  1  2        2  2     2     1  2|     35  1.9|
      Renal Tubule, Atrophy                |                                                                          |      1  1.0|
      Renal Tubule, Dilatation             |                                                                          |      2  1.0|
      Renal Tubule, Necrosis               |                                           3                              |      1  3.0|
      Renal Tubule, Regeneration           | 1  2     1  1  2  2  3     1     2  2        1  1  1  1  1  2  1  1     2|     43  1.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Concretion                           |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |       3                                                                  |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                                                         |             
      Clear Cell Focus                     |          2        3           3  1                                   X   |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |          2     X                                                  X  3   |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |       3                                                                  |             
      Thrombosis                           |                                                                          |             
      Hepatocyte, Nuclear Alteration       |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                            2                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             
      Acinar Cell, Cytoplasmic Alteration  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                         3|             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                            2                                             |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                 +   |             
      Dysplasia                            |    2                                                                 3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X                       X                     |             
      Hyperplasia, Focal                   |                                  1                                       |             
      Hypertrophy, Focal                   |          1  3  1  1           3     3                    1  1            |             
      Vacuolization Cytoplasmic            |          3                                                               |             
      Capsule, Hyperplasia                 |       3                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     3     4     2                       2                       2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      X                             X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             3  2                 2                                       |             
      Follicle, Cyst                       |                                                                X         |             
      Follicular Cell, Hyperplasia         | 1                             2     2                    2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                +                                                         |             
      Dilatation                           |                3                                                         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Ectasia                              |       3  2                 3  3     2     2           3              3  2|             
      Inflammation, Chronic                |       4           2                 2     3        4        4     2      |             
      Inflammation, Suppurative            | 4        3  2           3        1                       2  3        2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          3     3  3           3              3              3        4   |             
      Hemorrhage                           |                                                                         3|             
      Inflammation, Chronic                |                                                                         3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     | 3  2        2                             2           3                  |             
      Necrosis                             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                   3         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          3               |             
      Pigmentation                         |       2     2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                             |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hemorrhage                           | 1     2        2        1        2           3        3                  |             
      Hyperplasia, Lymphoid                | 3  3           2              3           2                              |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2        2           1        2     2  2  3  4     3           3      |             
      Lymphoid Follicle, Atrophy           |                            3                                   3         |             
      Red Pulp, Atrophy                    |                            3                                   3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                            3                                   3         |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    4                                                                     |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
      Necrosis                             |                                                 4                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                          1               |             
      Infiltration Cellular, Histiocyte    | 1                                      2        1  4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 1| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 2| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0312%                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1        2           2                 3                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  +     +  +        +  +  +  +  +           +               |             
      Hyperplasia                          |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |             2        1     1                          1  1              1|             
      Cyst                                 |                X  X           X                    X  X     X        X  X|             
      Hydronephrosis                       |             2                                   2                        |             
      Hyperplasia, Lymphoid                |    2        2                                3           2               |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |    2  1  2     2  2  2        2  2        2     2  1        2        1   |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Casts Protein          |                                                                         1|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Necrosis               |                                                 4                        |             
      Renal Tubule, Regeneration           | 1  2  1  2  3  2  2  2  1     2  3        1        1  1  1  2     1  1  1|             
      Transitional Epithelium, Hyperplasia |                                                 3                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Edema                                |    2  2     2                                                           2|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                 3                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             2                                            2               |             
      Clear Cell Focus                     |                      3                                                  2|             
      Congestion                           |                                     4                                    |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Inflammation, Subacute               |    1                                                                    3|             
      Mixed Cell Focus                     |                2                                                         |             
      Thrombosis                           | X                                                                        |             
      Hepatocyte, Nuclear Alteration       |             2                                                            |             
      Hepatocyte, Vacuolization Cytoplasmic|                                     4                                    |             
      Kupffer Cell, Hyperplasia            | 2                                                        3               |             
      Lobules, Necrosis                    |                                  1        4                          3   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                    +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                         1|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                          2               |             
      Erosion                              |                                                                          |             
      Mucosa, Hyperplasia                  |                                           2              2               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   2                             X                        |             
      Hyperplasia, Focal                   |                                                    2  1                  |             
      Hypertrophy, Focal                   |    2     2        3  1  2  1  3                 1                       1|             
      Vacuolization Cytoplasmic            |                                                                          |             
      Capsule, Hyperplasia                 |                            2  2                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3        2        3           2           2        3      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 3           1              1                                2     2      |             
      Follicle, Cyst                       |                                           X                              |             
      Follicular Cell, Hyperplasia         |                                                             3        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                      +   |             
      Dilatation                           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                X                                                        2|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                                                                          |             
      Ectasia                              |       2  3  3     2           3     3     3                 3            |             
      Inflammation, Chronic                |                   3     2     2              2  4  2  2     2     2      |             
      Inflammation, Suppurative            |             2     3                    2  2                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                         3                    3                       4   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     | 3                                3        2     3     3        3         |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hyperplasia, Lymphoid                |                                  2                    3                  |             
      Pigmentation                         |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  1                                   2                              |             
      Hemorrhage                           |    2  1  1           1        2           3        1                    1|             
      Hyperplasia, Lymphoid                |             2     2     3  2              2        4              2      |             
      Pigmentation                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4                 2  2           2     2  3  3                 4     3   |             
      Lymphoid Follicle, Atrophy           |                                                          2               |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       2     4                                3              1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 6| 4| 7| 4| 3| 3| 0| 2| 3| 8| 3| 3| 3|             
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 3| 8| 6| 7| 7| 5| 5| 7| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0312%                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |             3                                                            |             
      Alveolar Epithelium, Hyperplasia     |       2           2                          3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                +                                       |             
      Cataract                             | 2                                                                        |             
      Inflammation, Chronic                | 2                                                                        |             
      Phthisis Bulbi                       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +              +  +  +  +  +           +  +     +        +         |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                            1     1     2  2              1               |             
      Cyst                                 |       X           X              X                 X  X                  |             
      Hydronephrosis                       |                                                                         2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                         2                                                |             
      Mineralization                       |       2  2  2  2  2     2  1        1     2  2  2  2  3  2        2     1|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Casts Protein          |                                                                          |             
      Renal Tubule, Dilatation             |                                                                      1   |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Regeneration           |    2  2  2  1  2  1  2  2  1  1  2  3  3  3  2  2  1  2     1     2  2  1|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE MALE                        | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    0.0312%                                | 1|                                                                       |      L     |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M                                                                        |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  49        |
      Edema                                |                                                                          |      4  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M                                                                        |  48        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Basophilic Focus                     |                                                                          |      3  2.0|
      Clear Cell Focus                     |                                                                          |      7  2.3|
      Congestion                           |                                                                          |      1  4.0|
      Eosinophilic Focus                   |                                                                          |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Subacute               |                                                                          |      2  2.0|
      Mixed Cell Focus                     |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1     |
      Hepatocyte, Nuclear Alteration       |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  4.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      2  2.5|
      Lobules, Necrosis                    |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Atrophy                              |                                                                          |      1  2.0|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Diverticulum                         |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Dysplasia                            |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE MALE                        | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    0.0312%                                | 1|                                                                       |      L     |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      4  2.0|
      Hyperplasia, Focal                   |                                                                          |      3  1.3|
      Hypertrophy, Focal                   |                                                                          |     17  1.8|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Capsule, Hyperplasia                 |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |     12  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  48        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M                                                                        |  46        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Degeneration, Cystic                 |                                                                          |      8  2.0|
      Follicle, Cyst                       |                                                                          |      2     |
      Follicular Cell, Hyperplasia         |                                                                          |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
      Dilatation                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  51        |
      Spermatocele                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Ectasia                              | 2                                                                        |     18  2.6|
      Inflammation, Chronic                |                                                                          |     16  2.6|
      Inflammation, Suppurative            | 2                                                                        |     13  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  51        |
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE MALE                        | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    0.0312%                                | 1|                                                                       |      L     |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  51        |
      Dilatation                           |                                                                          |     10  3.2|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hypercellularity                     | 2                                                                        |     12  2.6|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   3        |
      Iliac, Hyperplasia, Lymphoid         | 3                                                                        |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  49        |
      Atrophy                              |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
      Pigmentation                         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  1.8|
      Hemorrhage                           |                                                                          |     15  1.7|
      Hyperplasia, Lymphoid                |                                                                          |     12  2.5|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hematopoietic Cell Proliferation     | 2                                                                        |     20  2.6|
      Lymphoid Follicle, Atrophy           | 3                                                                        |      4  2.8|
      Red Pulp, Atrophy                    |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  48        |
      Atrophy                              | 2                                                                        |      4  2.5|
      Congestion                           | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Ulcer                                | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE MALE                        | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    0.0312%                                | 1|                                                                       |      L     |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Hyperostosis                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           | 3                                                                        |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      8  2.3|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Exudate                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Phthisis Bulbi                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |  25        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Casts Protein                        |                                                                          |     11  1.3|
      Cyst                                 |                                                                          |     13     |
      Hydronephrosis                       |                                                                          |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |     29  1.8|
      Papilla, Necrosis                    | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 2|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE MALE                        | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    0.0312%                                | 1|                                                                       |      L     |
                                           | 6|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Casts Protein          |                                                                          |      1  1.0|
      Renal Tubule, Dilatation             |                                                                          |      1  1.0|
      Renal Tubule, Necrosis               |                                                                          |      1  4.0|
      Renal Tubule, Regeneration           |                                                                          |     41  1.7|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0625%                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    3                     |             
      Inflammation, Chronic                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             2           X                                                |             
      Clear Cell Focus                     | 3                                                              2         |             
      Cyst                                 |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                      2              2                    3           2  X|             
      Inflammation, Subacute               | 3  1  1                       2                                          |             
      Mineralization                       |                                                 2                        |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Hepatocyte, Nuclear Alteration       |                         2                                      2         |             
      Kupffer Cell, Hyperplasia            |                                                                         3|             
      Kupffer Cell, Pigmentation           |                                                                         3|             
      Lobules, Necrosis                    | 1                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Fat, Necrosis                        |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  2     2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                    1                     |             
      Mucosa, Hyperplasia                  |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +        +         |             
      Dysplasia                            |                                                       2        2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0625%                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia, Focal                   |                                  1                    2                  |             
      Hypertrophy, Focal                   |                1                    2        1  2     3     2  1  1  2   |             
      Capsule, Hyperplasia                 |                3           3           3                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                 3  2           2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    1  2                          1                 2                    1|             
      Follicle, Cyst                       |          X                                                               |             
      Follicular Cell, Hyperplasia         |                1                 1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |          4                                                               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                               3                                          |             
      Ectasia                              |    2  3  2  3  2  2  3  3        3  3     2     2  2     3        3  3  2|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    2           4              4              4     2        2  3  2  4   |             
      Inflammation, Suppurative            |       3     3  3  3  4  2                 3              3     3  2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2                                                                     |             
      Inflammation, Suppurative            |                   1                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3  2           3                       3              3        2     3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0625%                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                   2                             3  2     2           2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                +         |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Pigmentation                         |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2  3                                                   |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hemorrhage                           |                1     2  2        1  1  3           4        3     2     3|             
      Hyperplasia, Lymphoid                |    3                                                        3  2  3  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          3  3     2  3  3                 3              2              4|             
      Lymphoid Follicle, Hyperplasia       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |          X                                                               |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                   4                                                      |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     2                                1   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         3              2                                2|             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                          2              2           1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0625%                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Cornea, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +  +  +        +  +  +  +  +     +     +  +     +        +      |             
      Hyperplasia                          | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        | 1           3  1     3  3                                1              1|             
      Cyst                                 |                            X  X                                         X|             
      Hydronephrosis                       |                         2                                                |             
      Hyperplasia, Lymphoid                |             2        2           2           2                           |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |       3                                                                 2|             
      Mineralization                       | 2  2  2        2           1  2  2  2  2     2     1  2     2  3  1  2   |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Dilatation             |                                                             1            |             
      Renal Tubule, Pigmentation           |                                                                         3|             
      Renal Tubule, Regeneration           | 2  1  2     3  1  1  3  3  2  1  1  2  2     1  1  1  2  1  2  2  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6|            |
                                           | 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.0625%                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |             3                                                            |      3  2.5|
      Clear Cell Focus                     |                                                                         2|      3  2.3|
      Cyst                                 |          X                                                               |      1     |
      Developmental Malformation           |          X                                                               |      1     |
      Eosinophilic Focus                   | 2              2                                                         |      7  2.2|
      Inflammation, Subacute               |                                  1                                       |      5  1.6|
      Mineralization                       |             1                                                            |      2  1.5|
      Mixed Cell Focus                     | 2                                                                        |      1  2.0|
      Necrosis                             |                                                                   4      |      1  4.0|
      Hepatocyte, Nuclear Alteration       |                                     2                                    |      3  2.0|
      Kupffer Cell, Hyperplasia            |          3                                                               |      2  3.0|
      Kupffer Cell, Pigmentation           |                                                                2         |      2  2.5|
      Lobules, Necrosis                    |                                                          2     1     4   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinar Cell, Cytoplasmic Alteration  |          2        3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                    2                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                   2        3                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6|            |
                                           | 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.0625%                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                            +            |   4        |
      Dysplasia                            |                3                                            2            |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                      4   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       X                                      X                    X      |      3     |
      Hyperplasia, Focal                   |                         3     2                 2                 2     1|      7  1.9|
      Hypertrophy, Focal                   |                      1           2     1     3     2              1     1|     16  1.6|
      Capsule, Hyperplasia                 |                      3                 2                                 |      5  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2     2                       2                    2     2     2     2  2|     12  2.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                X                                   X                     |      4     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |       X                                            X                     |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |             2  1                             1              1     2      |     10  1.4|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |       1        1                                                         |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  4.0|
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                 3                        |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                   2     3                       3  2        3  2  3      |     24  2.5|
      Hyperplasia                          |                                                    3                     |      1  3.0|
      Inflammation, Chronic                | 3  2        4              2     2              3  3  2  2  2  2         |     20  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6|            |
                                           | 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.0625%                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            | 3                                      2           3        2     3      |     15  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                   3                             3  3        3            |     11  2.8|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |          2        3                       2                       2  2   |     10  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +        +                                      +      |   5        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         |          2                       2                       2     2  2      |      6  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     | 2                                                                    3   |      3  2.3|
      Hemorrhage                           | 2                    1              1                 1              4  1|     16  2.0|
      Hyperplasia, Lymphoid                |                                                       3     3            |      7  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                   +        +                                      +      |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |          3     1              1     2                          3  2  3   |     15  2.5|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +  M  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                2        1|      2  1.5|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Subacute               |                                                                1         |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Ulcer                                |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 0| 7| 7| 7| 6| 5| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 6| 3| 3| 7| 3| 3| 6| 3| 4| 3| 3| 3| 6| 3| 3| 6| 3| 6| 6|            |
                                           | 7| 8| 9| 7| 8| 8| 2| 8| 8| 2| 8| 8| 9| 8| 5| 8| 8| 8| 9| 6| 8| 8| 8| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.0625%                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                           X                              |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |       2                                                                  |      1  2.0|
      Infiltration Cellular, Histiocyte    |       2                    3                                             |      5  2.4|
      Thrombosis                           |                                     X                                    |      1     |
      Alveolar Epithelium, Hyperplasia     |       3                                                                  |      5  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +        +                             +  +                  |   4        |
      Cataract                             |             2                                                            |      1  2.0|
      Inflammation, Chronic                |             2        4                                3                  |      3  3.0|
      Cornea, Hyperplasia                  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +     +     +  +     +     +     +  +           +     +           +  +  +|  28        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts Protein                        |          1                                         1           2         |     10  1.7|
      Cyst                                 |                      X  X     X              X     X                     |      8     |
      Hydronephrosis                       |                                                                         2|      2  2.0|
      Hyperplasia, Lymphoid                |                                                    2                     |      5  2.0|
      Inflammation, Suppurative            |                                           3                              |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      2  2.5|
      Mineralization                       | 1     2     2  2  1  2  2  2  1  2  2  2     2  1  2  2  2  2     1  1  2|     37  1.8|
      Renal Tubule, Atrophy                |                                                                   2      |      1  2.0|
      Renal Tubule, Dilatation             |             1                                                     2      |      3  1.3|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           | 1  1  1  2  2  1  1  2  2  1  1  1  2  2     1  1  2  2  2  2  2  2     1|     45  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Edema                                |    2                                                        2        2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             2           3                                                |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                         2                                                |             
      Hematopoietic Cell Proliferation     |                      3                       4                           |             
      Hemorrhage                           |                                              1                           |             
      Inflammation, Subacute               |                                                             1            |             
      Mineralization                       |          1     3                                                         |             
      Mixed Cell Focus                     |                   3           3                                          |             
      Necrosis                             |                                                                          |             
      Kupffer Cell, Hyperplasia            |          3           2                                               3   |             
      Kupffer Cell, Pigmentation           |          1                                                           2   |             
      Lobules, Necrosis                    |             3        4                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                       +                           |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4                                                         |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Ulcer                                |                                           1                              |             
      Mucosa, Hyperplasia                  |       1                                               1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Ectopic Tissue                       | X                                                                        |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
      Dysplasia                            | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1        2     4                                                         |             
      Thrombosis                           |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                             X            |             
      Hyperplasia, Focal                   |                                        2                             2   |             
      Hypertrophy, Focal                   |    1                                   3  3           2  1     1         |             
      Capsule, Hyperplasia                 |    3              2                       3        2                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              1                           |             
      Hyperplasia                          |                         3                    1                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Pars Distalis, Cyst                  |                               X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       2                                      2                           |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                          |             
      Inflammation, Chronic                | 2                                                                        |             
      Spermatocele                         |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Ectasia                              |    3     3           4     2           4  3  2           3     2        3|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |             2     4     3     2     2              3                     |             
      Inflammation, Granulomatous          |                               2                                          |             
      Inflammation, Suppurative            |    2                 3                 3                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3              3                                            3     3      |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                   3  4  2     3        2     3                       2   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +                                                   |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                      2                                                   |             
      Inguinal, Hyperplasia, Lymphoid      |                   3  2                                                   |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                      3                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hyperplasia, Lymphoid                |    2                 2                             3                     |             
      Pigmentation                         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              3                       2   |             
      Hemorrhage                           | 2  2     3     2  2           2           1                       3  2   |             
      Hyperplasia, Lymphoid                |                                           4                              |             
      Pigmentation                         |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                2  2  4                 1     4  3                    2   |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      3                                                  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 7| 5| 7| 6| 4| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 2|             
                             DAY ON TEST   | 6| 3| 3| 8| 0| 3| 9| 3| 6| 4| 3| 6| 3| 2| 3| 6| 9| 2| 3| 3| 3| 1| 3| 3| 4|             
                                           | 9| 8| 8| 9| 3| 8| 2| 8| 9| 5| 8| 5| 8| 5| 8| 9| 3| 5| 8| 8| 8| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.125%                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |    2                       2                 1                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                2     2        2           2                              |             
      Thrombosis                           |             X                                                            |             
      Alveolar Epithelium, Hyperplasia     |       3        3  2                                      2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                           2                       2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                    +                          +        +            |             
      Cataract                             |    3                                                                     |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +     +  +  +     +  +        +     +     +     +  +  +  +        +  +|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                                 1                    1   |             
      Cyst                                 |          X     X     X        X                                      X   |             
      Hydronephrosis                       |                                           2                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization                       | 1  1  1  2  1           2     3  2  1  1  2           2  2               |             
      Renal Tubule, Atrophy                |                4                                                         |             
      Renal Tubule, Dilatation             |                                                                   1      |             
      Renal Tubule, Hyperplasia            |                                                          2               |             
      Renal Tubule, Regeneration           |    1  1        1     1  1     2  1  1           1  1  1  2  1     2  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  +  M  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                2                       2  2           2              2   |      8  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                            3                                             |      3  2.7|
      Clear Cell Focus                     |       2        2                                                         |      2  2.0|
      Eosinophilic Focus                   |       X           3                                                      |      3  2.5|
      Hematopoietic Cell Proliferation     |                                        3     2                           |      4  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Subacute               |    2                                                           1         |      3  1.3|
      Mineralization                       |                                                                          |      2  2.0|
      Mixed Cell Focus                     |                                                                          |      2  3.0|
      Necrosis                             |                                                          4               |      1  4.0|
      Kupffer Cell, Hyperplasia            |                            3                                2            |      5  2.6|
      Kupffer Cell, Pigmentation           |                                                                          |      2  1.5|
      Lobules, Necrosis                    |    1                                                                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   3        |
      Fat, Necrosis                        |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  4.0|
      Acinar Cell, Cytoplasmic Alteration  |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ulcer                                | 1                          4                                             |      3  2.0|
      Mucosa, Hyperplasia                  |                            4                             2               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectopic Tissue                       |                                                                          |      1     |
      Mucosa, Hyperplasia                  |                                           2                       3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                 +                                                |   3        |
      Dysplasia                            |       2                 2                                                |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      3  2.3|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                         X|      2     |
      Hyperplasia, Focal                   |          1                                                               |      3  1.7|
      Hypertrophy, Focal                   |                         3                 2                             1|      9  1.9|
      Capsule, Hyperplasia                 |                                                    2                     |      5  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia                          |       3           2     2                          2                     |      6  2.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Cyst                  |       X                                                           X      |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                   3                 2  2                                1|      6  2.0|
      Follicular Cell, Hyperplasia         |    1                                                              2      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hypospermia                          |                      X                                                   |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Spermatocele                         |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              | 4        2        3        4        3  3  2           2  2  3           3|     21  2.9|
      Hyperplasia                          |                            3                                             |      1  3.0|
      Inflammation, Chronic                |                   2              2              2        2  2           4|     12  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                4           4  3        3  3           3     2           3|     11  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |       3  3                       4                                4      |      8  3.3|
      Fibrosis                             |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Seminiferous Tubule, Atrophy         |                      3                                                   |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hypercellularity                     |    3                          3        4     2              4  2         |     13  2.8|
      Necrosis                             |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +           +           +                                 |   6        |
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                3                                                         |      3  2.7|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     |                                        2                                 |      2  2.5|
      Hyperplasia, Lymphoid                |                               2                          2               |      5  2.2|
      Pigmentation                         |                                        2                             2   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                              2                          2|      2  2.0|
      Hematopoietic Cell Proliferation     |                                           1           2  2               |      5  2.0|
      Hemorrhage                           |    3  2  2     3        3        3  1     1        2  3  1     2        1|     22  2.1|
      Hyperplasia, Lymphoid                |                   3  3        2                                          |      4  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                        +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                            3  1        4  1  4        3  2  3  2     1   |     17  2.5|
      Infiltration Cellular, Mast Cell     |                                                                         3|      1  3.0|
      Lymphoid Follicle, Atrophy           | 2                                                                        |      1  2.0|
      Lymphoid Follicle, Hyperplasia       |                      2                                                   |      1  2.0|
      Red Pulp, Atrophy                    | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +|  42        |
      Atrophy                              | 2                                      3                                 |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                        4                                 |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperostosis                         |                                                    3     3           3   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          | X                                                                        |      1     |
      Cyst                                 |                                     X                                    |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                         3|      1  3.0|
      Infiltration Cellular, Histiocyte    |                   2           2     4           2                       2|      9  2.2|
      Thrombosis                           |                                           X                              |      2     |
      Alveolar Epithelium, Hyperplasia     |                                     3     1        1  1                  |      8  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Exudate                              |                                                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                 +                          +  +     +               |   9        |
      Cataract                             |                                                 2                        |      2  2.5|
      Inflammation, Chronic                |    2                 2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +     +     +  +        +        +  +  +  +     +  +     +  +  +|  32        |
      Hyperplasia                          |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Casts Protein                        |                                              1                       2   |      4  1.3|
      Cyst                                 |                   X     X     X     X        X     X                     |     11     |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                   2                                                  2   |      2  2.0|
      Mineralization                       | 1  2  2        2  3     2  1        1  1        2  1  1  1  2  1  2     2|     30  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05103-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/13/94  
Route: DOSED FEED                                                                                                 Time: 14:35:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 9| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 8| 8| 8| 0| 8| 8| 9| 8| 2| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 1| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.125%                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Atrophy                |                                                          1               |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                      2                                                   |      2  2.0|
      Renal Tubule, Regeneration           | 1  1  3  2     1  2  1        1  2  1  1  1  1  1  1  1  3     1  1  3  2|     36  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                           3                              |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
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                             ----------              END OF REPORT             ----------                                           
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