National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1793

TDMS Study 05103-05 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL


NTP Experiment-Test: 05103-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 19:49:13




       Facility:  Southern Research Institute

       Chemical CAS #:  3296-90-0

       Lock Date:  02/18/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9            7            8                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           22           27           41                                     
    Natural Death                                                   2            3            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           23            5                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                                    1 (2%)      10 (17%)                               
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (60)         (59)         (60)         (60)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Multiple, Metastatic, Islets,                                                                                      
           Pancreatic                                  1 (2%)                                                                       
   Mesentery                                          (6)          (12)         (9)          (6)                                    
      Histiocytic Sarcoma                              1 (17%)                                                                      
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Pharynx                                            (1)          (1)          (1)          (2)                                    
      Palate, Squamous Cell Carcinoma                               1 (100%)     1 (100%)                                           
      Palate, Squamous Cell Papilloma                  1 (100%)                               1 (50%)                               
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Tongue                                             (1)          (3)          (6)          (6)                                    
      Squamous Cell Carcinoma                                                                 1 (17%)                               
      Squamous Cell Papilloma                          1 (100%)     2 (67%)      4 (67%)      4 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (60)         (60)         (60)                                   
      Pericardium, Histiocytic Sarcoma                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                                       2 (3%)       1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (58)         (60)         (59)         (59)                                   
      Pars Distalis, Adenoma                          16 (28%)     24 (40%)     24 (41%)     16 (27%)                               
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      C-Cell, Adenoma                                  6 (10%)      5 (8%)       7 (12%)      4 (7%)                                
      C-Cell, Carcinoma                                2 (3%)       3 (5%)                                                          
      Follicular Cell, Adenoma                                                   2 (3%)       4 (7%)                                
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (58)         (56)         (60)                                   
      Adenoma                                          3 (5%)       3 (5%)       7 (13%)      3 (5%)                                
      Carcinoma                                        1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                 1 (2%)                                
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Endometrium, Adenoma                                                       1 (2%)                                             
      Endometrium, Carcinoma                                                                  1 (2%)                                
      Endometrium, Polyp Stromal                       4 (7%)       8 (13%)      7 (12%)      6 (10%)                               
      Endometrium, Polyp Stromal, Multiple             1 (2%)                                 1 (2%)                                
      Endometrium, Sarcoma Stromal                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (16)         (11)         (15)         (19)                                   
      Histiocytic Sarcoma                              1 (6%)                                                                       
      Inguinal, Histiocytic Sarcoma                    1 (6%)                                                                       
   Lymph Node, Mandibular                             (59)         (57)         (60)         (58)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
   Thymus                                             (59)         (59)         (58)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenoma                                                       2 (3%)                                                          
      Carcinoma                                        3 (5%)       4 (7%)       3 (5%)       4 (7%)                                
      Carcinoma, Multiple                              1 (2%)                                                                       
      Fibroadenoma                                    20 (33%)      9 (15%)      6 (10%)      9 (15%)                               
      Fibroadenoma, Multiple                           6 (10%)     37 (62%)     40 (67%)     39 (65%)                               
   Skin                                               (60)         (60)         (60)         (60)                                   
      Keratoacanthoma                                                            2 (3%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          3 (5%)                    1 (2%)                                             
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       4 (7%)       1 (2%)       2 (3%)                                
      Subcutaneous Tissue, Fibrosarcoma                                                       2 (3%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                   2 (3%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                 2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                       (1)                                    
      Histiocytic Sarcoma                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (60)         (60)         (60)                                   
      Astrocytoma NOS                                                            1 (2%)       1 (2%)                                
      Oligodendroglioma NOS                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    2 (3%)                                
      Carcinoma, Multiple, Metastatic, Islets,                                                                                      
           Pancreatic                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Mediastinum, Histiocytic Sarcoma                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (2)          (2)          (1)                                    
      Adenoma                                                       1 (50%)                                                         
      Carcinoma                                                                  2 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Stromal Nephroma                                                           1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Transitional Epithelium, Papilloma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            15 (25%)     13 (22%)     19 (32%)     19 (32%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.25%        0.50%        1.00%                                     
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          52          56          57                                       
     Total Primary Neoplasms                           93         127         135         138                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          50          52          53                                       
     Total Benign Neoplasms                            66         103         106         102                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          22          27          31                                       
     Total Malignant Neoplasms                         26          24          28          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1           1                                       
     Total Uncertain Neoplasms                          1                       1           1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           60           60           60           70                        
  Scheduled Sacrifice                                 19            7            9            5           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           30           36           43           55                        
    Natural Death                                      1            3            2           11            5                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           20           13            1                                     
  Animals Examined Microscopically                    70           60           60           60           70                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (70)         (60)         (60)         (60)         (70)                      
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                    1 (2%)       5 (8%)                                
   Intestine Large, Colon                             (70)         (59)         (60)         (59)         (69)                      
      Carcinoma                                                                                            1 (1%)                   
      Carcinoma, Multiple                                                                                  1 (1%)                   
      Hemangioma                                                                              1 (2%)                                
      Leiomyoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Adenomatous                                                          3 (5%)       4 (7%)       8 (12%)                  
      Polyp Adenomatous, Multiple                                                                          1 (1%)                   
   Intestine Large, Rectum                            (70)         (59)         (59)         (58)         (69)                      
      Polyp Adenomatous                                                                                    1 (1%)                   
   Intestine Large, Cecum                             (70)         (59)         (60)         (59)         (69)                      
   Intestine Small, Duodenum                          (70)         (60)         (60)         (57)         (69)                      
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (1%)                   
   Intestine Small, Jejunum                           (70)         (59)         (60)         (58)         (69)                      
      Carcinoma                                                                               2 (3%)       2 (3%)                   
      Polyp Adenomatous                                                                                    1 (1%)                   
   Intestine Small, Ileum                             (70)         (59)         (60)         (58)         (69)                      
      Carcinoma                                                                                            1 (1%)                   
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (1%)                   
      Mucosa, Carcinoma                                                                                    1 (1%)                   
   Liver                                              (70)         (60)         (60)         (60)         (70)                      
      Hepatocellular Carcinoma                                                                             1 (1%)                   
      Hepatocellular Adenoma                                        1 (2%)                                                          
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
      Sarcoma                                                                                 1 (2%)                                
      Sarcoma, Metastatic, Spleen                                                             1 (2%)                                
   Mesentery                                          (16)         (20)         (21)         (23)         (30)                      
      Carcinoma, Metastatic, Seminal Vesicle                                                               1 (3%)                   
                                                             Page   7                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fibroma                                                       1 (5%)                                                          
      Hemangiosarcoma                                                            1 (5%)                                             
      Sarcoma                                                                                 2 (9%)                                
   Pancreas                                           (70)         (60)         (60)         (58)         (69)                      
      Sarcoma                                                                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (1%)                   
      Acinar Cell, Adenoma                             1 (1%)       2 (3%)       4 (7%)       2 (3%)       2 (3%)                   
      Acinar Cell, Adenoma, Multiple                                                          1 (2%)       1 (1%)                   
   Pharynx                                            (1)          (3)          (4)          (5)          (10)                      
      Palate, Squamous Cell Carcinoma                                                                      2 (20%)                  
      Palate, Squamous Cell Papilloma                               2 (67%)      3 (75%)      2 (40%)      7 (70%)                  
   Salivary Glands                                    (70)         (59)         (58)         (60)         (70)                      
   Stomach, Forestomach                               (70)         (60)         (60)         (60)         (69)                      
      Sarcoma                                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                                 1 (2%)       4 (6%)                   
      Mucosa, Squamous Cell Papilloma                                                                      1 (1%)                   
   Stomach, Glandular                                 (70)         (60)         (60)         (58)         (70)                      
      Sarcoma                                                                                 1 (2%)                                
   Tongue                                                          (2)          (5)          (13)         (9)                       
      Squamous Cell Papilloma                                       2 (100%)     5 (100%)     8 (62%)      5 (56%)                  
      Squamous Cell Papilloma, Multiple                                                                    1 (11%)                  
   Tooth                                              (1)                       (1)                       (2)                       
      Gingiva, Squamous Cell Carcinoma                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (60)         (60)         (60)         (70)                      
      Carcinoma, Metastatic, Seminal Vesicle                                                               1 (1%)                   
      Schwannoma NOS                                   1 (1%)       1 (2%)       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (60)         (60)         (59)         (70)                      
      Adenoma                                          1 (1%)       1 (2%)       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (1%)                   
   Adrenal Medulla                                    (70)         (60)         (60)         (59)         (70)                      
      Pheochromocytoma Malignant                       3 (4%)       3 (5%)       1 (2%)       1 (2%)                                
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          6 (9%)       9 (15%)      4 (7%)       4 (7%)                                
      Bilateral, Pheochromocytoma Benign               1 (1%)       3 (5%)                                                          
   Islets, Pancreatic                                 (70)         (60)         (60)         (60)         (69)                      
      Adenoma                                          1 (1%)       6 (10%)      1 (2%)                                             
      Carcinoma                                                     2 (3%)       1 (2%)                                             
   Parathyroid Gland                                  (68)         (57)         (58)         (58)         (68)                      
                                                             Page   8                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (69)         (58)         (59)         (58)         (67)                      
      Pars Distalis, Adenoma                           9 (13%)     10 (17%)      6 (10%)      6 (10%)      5 (7%)                   
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                         1 (1%)                                              1 (1%)                   
   Thyroid Gland                                      (70)         (60)         (60)         (60)         (69)                      
      Bilateral, C-Cell, Carcinoma                                                            1 (2%)                                
      C-Cell, Adenoma                                  7 (10%)      5 (8%)       4 (7%)       4 (7%)       4 (6%)                   
      C-Cell, Carcinoma                                1 (1%)       1 (2%)       1 (2%)       2 (3%)                                
      Follicular Cell, Adenoma                                      1 (2%)       2 (3%)       2 (3%)       7 (10%)                  
      Follicular Cell, Carcinoma                                    1 (2%)       4 (7%)       1 (2%)       2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (3)          (6)          (8)                       
      Pelvic, Chordoma                                                                        1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (60)         (60)         (59)         (70)                      
   Penis                                                           (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
   Preputial Gland                                    (70)         (59)         (60)         (60)         (70)                      
      Adenoma                                          3 (4%)       3 (5%)       4 (7%)       4 (7%)       4 (6%)                   
      Carcinoma                                        2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Duct, Squamous Cell Papilloma                    1 (1%)                                                                       
   Prostate                                           (70)         (60)         (60)         (60)         (70)                      
      Carcinoma, Metastatic, Seminal Vesicle                                                               1 (1%)                   
   Seminal Vesicle                                    (70)         (60)         (60)         (60)         (70)                      
      Adenoma                                                                                              1 (1%)                   
      Carcinoma                                                                                            1 (1%)                   
   Testes                                             (70)         (60)         (60)         (60)         (70)                      
      Bilateral, Interstitial Cell, Adenoma           52 (74%)     50 (83%)     56 (93%)     52 (87%)     52 (74%)                  
      Interstitial Cell, Adenoma                       5 (7%)       4 (7%)       4 (7%)       4 (7%)       7 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (60)         (60)         (60)         (70)                      
   Lymph Node                                         (25)         (23)         (36)         (27)         (31)                      
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                          1 (3%)                                             
   Lymph Node, Mandibular                             (68)         (59)         (58)         (60)         (69)                      
   Lymph Node, Mesenteric                             (69)         (60)         (60)         (60)         (70)                      
   Spleen                                             (70)         (60)         (60)         (59)         (70)                      
      Carcinoma, Metastatic, Seminal Vesicle                                                               1 (1%)                   
                                                             Page   9                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Fibroma                                                                                 1 (2%)                                
      Sarcoma                                          1 (1%)                                 1 (2%)                                
   Thymus                                             (67)         (60)         (58)         (57)         (67)                      
      Epithelial Cell, Thymoma Malignant                                                      1 (2%)                                
      Epithelial Cell, Thymoma NOS                                                                         1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (66)         (58)         (57)         (53)         (60)                      
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Fibroadenoma                                                  3 (5%)       4 (7%)       6 (11%)      4 (7%)                   
      Fibroadenoma, Multiple                                        1 (2%)       2 (4%)                    1 (2%)                   
   Skin                                               (70)         (60)         (60)         (59)         (69)                      
      Basal Cell Adenoma                                            1 (2%)                    3 (5%)       6 (9%)                   
      Basal Cell Carcinoma                                                       2 (3%)       2 (3%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Keratoacanthoma                                  2 (3%)       5 (8%)       9 (15%)     16 (27%)      9 (13%)                  
      Keratoacanthoma, Multiple                        1 (1%)                    2 (3%)                    1 (1%)                   
      Squamous Cell Carcinoma                                                                              1 (1%)                   
      Squamous Cell Papilloma                          1 (1%)       1 (2%)       2 (3%)       5 (8%)      10 (14%)                  
      Squamous Cell Papilloma, Multiple                                                       1 (2%)       1 (1%)                   
      Trichoepithelioma                                                                       1 (2%)       1 (1%)                   
      Pinna, Melanoma Malignant                                     1 (2%)                                                          
      Sebaceous Gland, Adenoma                                      1 (2%)                    2 (3%)       2 (3%)                   
      Subcutaneous Tissue, Carcinoma, Metastatic,                                                                                   
           Thyroid Gland                                                         1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (3%)       8 (13%)      7 (12%)      9 (15%)      7 (10%)                  
      Subcutaneous Tissue, Fibroma, Multiple                                     4 (7%)       6 (10%)                               
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                 1 (1%)                   
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               2 (3%)       2 (3%)       2 (3%)                   
      Subcutaneous Tissue, Sarcoma, Multiple                                                  1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                     2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (60)         (60)         (60)         (70)                      
      Osteosarcoma                                     1 (1%)                                                                       
   Skeletal Muscle                                                 (3)          (2)          (4)          (4)                       
      Hemangiosarcoma                                                                                      1 (25%)                  
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (25%)                  
      Thymoma Malignant, Metastatic                                                           1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (60)         (60)         (60)         (70)                      
      Astrocytoma NOS                                                            1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Oligodendroglioma NOS                                         1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (60)         (60)         (60)         (70)                      
      Alveolar/Bronchiolar Adenoma                     1 (1%)                    3 (5%)       1 (2%)       4 (6%)                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    2 (3%)       2 (3%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple                                                1 (2%)       1 (1%)                   
      Carcinoma, Multiple, Metastatic, Seminal                                                                                      
          Vesicle                                                                                          1 (1%)                   
      Carcinoma, Multiple, Metastatic, Thyroid                                                                                      
          Gland                                                                               1 (2%)                                
      Carcinoma, Multiple, Metastatic, Zymbal's                                                                                     
          Gland                                        1 (1%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                                                   2 (3%)       1 (1%)                   
      Chordoma, Metastatic, Tissue NOS                                                        1 (2%)                                
      Sarcoma                                                                                 1 (2%)                                
      Sarcoma, Metastatic, Tissue NOS                               1 (2%)                                                          
      Squamous Cell Carcinoma                                                                              3 (4%)                   
      Thymoma Malignant, Metastatic, Thymus                                                   1 (2%)                                
   Nose                                               (70)         (60)         (60)         (60)         (70)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (3)                       (1)                       
      Lids, Melanoma NOS                               1 (50%)                   1 (33%)                                            
   Zymbal's Gland                                     (2)          (1)          (5)          (5)          (15)                      
      Adenoma                                                                    1 (20%)      3 (60%)      2 (13%)                  
      Carcinoma                                        2 (100%)     1 (100%)     3 (60%)      2 (40%)     13 (87%)                  
      Bilateral, Carcinoma                                                                                 2 (13%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (60)         (60)         (60)         (69)                      
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (1%)                   
      Pelvis, Transitional Epithelium, Carcinoma                                              1 (2%)       1 (1%)                   
      Renal Tubule, Adenoma                                                      1 (2%)       3 (5%)       1 (1%)                   
   Urinary Bladder                                    (70)         (60)         (60)         (60)         (69)                      
      Transitional Epithelium, Carcinoma                                                      1 (2%)       1 (1%)                   
                                                             Page  11                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Papilloma                                         1 (2%)       3 (5%)       1 (1%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(60)        *(60)        *(60)        *(70)                      
      Leukemia Mononuclear                            28 (40%)     29 (48%)     40 (67%)     34 (57%)     25 (36%)                  
      Mesothelioma Malignant                                        4 (7%)       9 (15%)      9 (15%)     26 (37%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05103-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL                           Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 19:49:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.25%        0.50%        1.00%        2.00%                        
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          59          60          59          60                           
     Total Primary Neoplasms                          135         173         207         237         255                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 59          59          60          59          59                           
     Total Benign Neoplasms                            95         122         137         161         163                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          36          47          50          55                           
     Total Malignant Neoplasms                         38          49          67          76          91                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           1           6           4                           
     Total Metastatic Neoplasm                          1           4           2           8          16                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2           2           3                       1                           
     Total Uncertain Neoplasms                          2           2           3                       1                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.