National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1801

TDMS Study 05106-03 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          DIETHYLPHTHALATE


NTP Experiment-Test: 05106-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  03/16/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            8            7            5                                     
    Moribund Sacrifice                                 4            5            5            8                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Natural Death                                                   1            1                                                  
    Terminal Sacrifice                                41           37           36           36                                     
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    60           55           53           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (58)         (44)         (50)         (58)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Intestine Small, Ileum                             (57)         (44)         (49)         (57)                                   
      Abscess                                          1 (2%)                                                                       
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Liver                                              (60)         (55)         (53)         (60)                                   
      Basophilic Focus                                 2 (3%)       3 (5%)       6 (11%)      2 (3%)                                
      Clear Cell Focus                                 2 (3%)                    3 (6%)       1 (2%)                                
      Clear Cell Focus, Multiple                                    1 (2%)                                                          
      Cyst                                                          1 (2%)       1 (2%)                                             
      Eosinophilic Focus                               1 (2%)       4 (7%)       3 (6%)       3 (5%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       3 (5%)                                                          
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Inflammation, Chronic, Focal                    15 (25%)     13 (24%)     13 (25%)     10 (17%)                               
      Mixed Cell Focus                                 1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Necrosis, Focal                                  1 (2%)       6 (11%)      3 (6%)       2 (3%)                                
      Centrilobular, Degeneration                                   1 (2%)                                                          
      Centrilobular, Hypertrophy                                    1 (2%)                                                          
      Centrilobular, Necrosis                                                    1 (2%)                                             
      Centrilobular, Vacuolization Cytoplasmic                                                1 (2%)                                
      Hepatocyte, Hyperplasia, Focal                                1 (2%)       1 (2%)                                             
   Mesentery                                                                                 (3)                                    
      Fat, Necrosis                                                                           2 (67%)                               
   Pancreas                                           (59)         (51)         (50)         (59)                                   
      Abscess                                                       1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                                 1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Edema                                                                      1 (2%)       1 (2%)                                
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Polyarteritis                                                 1 (2%)                                                          
      Duct, Ectasia                                    1 (2%)                                 1 (2%)                                
   Salivary Glands                                    (60)         (51)         (50)         (60)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (51)         (50)         (60)                                   
      Erosion                                          1 (2%)       1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                                                          
      Muscularis, Mineralization                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (51)         (50)         (60)                                   
      Cardiomyopathy                                   1 (2%)       1 (2%)       2 (4%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Atrium, Thrombosis                                                                      1 (2%)                                
      Myocardium, Necrosis, Focal                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (51)         (50)         (60)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Cyst                                             2 (3%)       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)       1 (2%)                                
      Hyperplasia, Focal                               1 (2%)                    5 (10%)      3 (5%)                                
      Hypertrophy, Focal                               2 (3%)       2 (4%)                                                          
      Pigmentation                                                  1 (2%)                                                          
      Capsule, Hyperplasia                            57 (95%)     51 (100%)    50 (100%)    58 (97%)                               
   Adrenal Gland                                      (48)         (42)         (46)         (48)                                   
      Corticomedullary Junction, Congestion            5 (10%)      6 (14%)      3 (7%)       7 (15%)                               
      Corticomedullary Junction, Degeneration         41 (85%)     39 (93%)     44 (96%)     46 (96%)                               
      Corticomedullary Junction, Hemorrhage            3 (6%)       3 (7%)       7 (15%)      2 (4%)                                
      Corticomedullary Junction, Pigmentation         13 (27%)     14 (33%)      8 (17%)     13 (27%)                               
   Adrenal Medulla                                    (60)         (51)         (50)         (60)                                   
      Hyperplasia, Focal                               1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (57)         (48)         (47)         (60)                                   
      Cyst                                             1 (2%)                    4 (9%)       1 (2%)                                
   Pituitary Gland                                    (59)         (48)         (50)         (59)                                   
      Angiectasis                                                                1 (2%)                                             
      Cyst                                             1 (2%)       2 (4%)       4 (8%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                4 (7%)      10 (21%)      9 (18%)      9 (15%)                               
   Thyroid Gland                                      (60)         (51)         (50)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
      C-Cell, Hyperplasia                              5 (8%)       2 (4%)       1 (2%)       2 (3%)                                
      Follicle, Cyst                                   1 (2%)                    4 (8%)       1 (2%)                                
      Follicle, Dilatation                                                                    1 (2%)                                
      Follicle, Necrosis                                                                      1 (2%)                                
      Follicular Cell, Hyperplasia                     9 (15%)     12 (24%)      5 (10%)      8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (51)         (49)         (59)                                   
      Atrophy                                         38 (64%)     36 (71%)     42 (86%)     37 (63%)                               
      Congestion                                       1 (2%)                                                                       
      Cyst                                            21 (36%)     23 (45%)     20 (41%)     16 (27%)                               
      Cyst Dermoid                                                                            1 (2%)                                
      Hematocyst                                       7 (12%)     16 (31%)      6 (12%)     15 (25%)                               
      Pigmentation                                     1 (2%)                                 1 (2%)                                
   Uterus                                             (60)         (51)         (49)         (60)                                   
      Dilatation                                                    3 (6%)       2 (4%)       1 (2%)                                
      Endometrium, Hyperplasia, Cystic                59 (98%)     49 (96%)     47 (96%)     60 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (51)         (50)         (60)                                   
      Sternal, Myelofibrosis                          45 (75%)     45 (88%)     43 (86%)     46 (77%)                               
   Lymph Node                                         (7)          (7)          (5)          (8)                                    
      Hyperplasia, Lymphoid                            1 (14%)                                1 (13%)                               
      Hemal, Necrosis                                               1 (14%)                                                         
      Mediastinal, Pigmentation                                                               1 (13%)                               
      Pancreatic, Hyperplasia, Lymphoid                                          1 (20%)                                            
      Pancreatic, Inflammation, Chronic                1 (14%)                                                                      
      Pancreatic, Lymphatic, Ectasia                                                          1 (13%)                               
      Renal, Pigmentation                                                                     1 (13%)                               
      Thoracic, Hyperplasia                            1 (14%)                                                                      
   Lymph Node, Mandibular                             (56)         (47)         (47)         (57)                                   
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (45)         (48)         (60)                                   
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Spleen                                             (60)         (51)         (50)         (60)                                   
      Hematopoietic Cell Proliferation                43 (72%)     44 (86%)     47 (94%)     44 (73%)                               
      Hyperplasia, Lymphoid                            6 (10%)      1 (2%)       3 (6%)       3 (5%)                                
      Hyperplasia, Reticulum Cell                                                             1 (2%)                                
      Infarct                                          1 (2%)                                                                       
      Capsule, Fibrosis                                1 (2%)                                                                       
      Vein, Dilatation                                 1 (2%)                                                                       
   Thymus                                             (51)         (40)         (35)         (55)                                   
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (46)         (50)         (54)                                   
      Hyperplasia                                      1 (2%)       1 (2%)       3 (6%)       2 (4%)                                
   Skin                                               (60)         (51)         (50)         (60)                                   
      Acanthosis, Focal                                             1 (2%)                                                          
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Edema                                                         1 (2%)       1 (2%)                                             
      Exudate                                                       1 (2%)                                                          
      Control, Edema                                                             1 (2%)                                             
      Site of Application-No Mass, Exudate                          1 (2%)                                                          
      Site of Application-No Mass, Ulcer               1 (2%)                                                                       
      Subcutaneous Tissue, Control, Inflammation                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (51)         (50)         (60)                                   
      Vertebra, Fracture                                                                      1 (2%)                                
   Skeletal Muscle                                    (1)          (1)          (1)          (4)                                    
      Hemorrhage, Focal                                                          1 (100%)                                           
      Abdominal, Pigmentation                                                                 1 (25%)                               
      Diaphragm, Pigmentation                                                                 1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (51)         (50)         (60)                                   
      Compression                                      1 (2%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Hydrocephalus                                                 1 (2%)                                                          
      Mineralization, Focal                           42 (70%)     34 (67%)     36 (72%)     35 (58%)                               
      Brain Stem, Hemorrhage                                                     1 (2%)                                             
   Spinal Cord                                                                  (2)          (2)                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Hemorrhage                                                                 1 (50%)      1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (51)         (50)         (60)                                   
      Adenomatosis, Focal                              1 (2%)                    1 (2%)                                             
      Congestion                                       4 (7%)       5 (10%)      2 (4%)       2 (3%)                                
      Hemorrhage, Focal                                1 (2%)                    1 (2%)       1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Infarct                                                                                 1 (2%)                                
      Infiltration Cellular, Multifocal, Lymphocyte                                           1 (2%)                                
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       2 (4%)       1 (2%)       4 (7%)                                
      Alveolar Epithelium, Hyperplasia, Focal                                    1 (2%)       4 (7%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       2 (4%)       1 (2%)       3 (5%)                                
      Peribronchial, Hyperplasia, Lymphoid            28 (47%)     15 (29%)     11 (22%)     15 (25%)                               
   Nose                                               (60)         (50)         (50)         (60)                                   
      Hemorrhage                                                                              1 (2%)                                
   Trachea                                            (60)         (51)         (50)         (60)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)                                                 
      Cornea, Inflammation, Subacute                                             1 (100%)                                           
      Cornea, Necrosis                                 1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (50)         (60)                                   
      Metaplasia, Focal, Osseous                                    1 (2%)                    1 (2%)                                
      Metaplasia, Osseous                              2 (3%)                                                                       
      Nephropathy                                      9 (15%)     18 (35%)     15 (30%)     10 (17%)                               
      Capsule, Inflammation, Focal                                  1 (2%)                                                          
      Cortex, Atrophy, Focal                           2 (3%)       4 (8%)       3 (6%)       3 (5%)                                
      Cortex, Cyst                                     1 (2%)       1 (2%)                                                          
      Cortex, Metaplasia, Focal, Osseous                            1 (2%)                                                          
      Pelvis, Crystals                                 1 (2%)                                                                       
      Pelvis, Dilatation                               1 (2%)       2 (4%)       1 (2%)       2 (3%)                                
      Proximal Convoluted Renal Tubule,                                                                                             
          Cytoplasmic Alteration                                    2 (4%)       1 (2%)                                             
      Renal Tubule, Mineralization, Focal              1 (2%)       2 (4%)       3 (6%)       2 (3%)                                
   Urinary Bladder                                    (59)         (47)         (49)         (58)                                   
      Infiltration Cellular, Focal, Lymphocyte                                                1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                                                   1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            4            2            6                                     
    Moribund Sacrifice                                 2            3            2            1                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           41           46           43                                     
  Missing                                                           1                                                               
  Animals Examined Microscopically                    60           53           51           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (57)         (49)         (48)         (56)                                   
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Intestine Small, Ileum                             (57)         (48)         (48)         (56)                                   
      Congestion                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
   Liver                                              (60)         (53)         (51)         (60)                                   
      Basophilic Focus                                              1 (2%)       9 (18%)      3 (5%)                                
      Clear Cell Focus                                 2 (3%)       2 (4%)       2 (4%)       3 (5%)                                
      Clear Cell Focus, Multiple                                    1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)                                 2 (3%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage, Focal                                                                       1 (2%)                                
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic, Focal                                  1 (2%)                    3 (5%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mixed Cell Focus                                                           1 (2%)                                             
      Necrosis, Focal                                  4 (7%)       1 (2%)       2 (4%)       3 (5%)                                
      Bile Duct, Hyperplasia, Focal                                              1 (2%)                                             
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Sinusoid, Dilatation                             1 (2%)                                                                       
      Vein, Dilatation                                 1 (2%)                                                                       
   Mesentery                                          (2)          (2)          (2)                                                 
      Hemorrhage                                                                 1 (50%)                                            
      Fat, Necrosis                                    2 (100%)     1 (50%)      1 (50%)                                            
   Pancreas                                           (60)         (49)         (50)         (60)                                   
      Atrophy, Focal                                                                          1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Edema                                                         1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hypertrophy, Focal                               1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Duct, Ectasia                                    1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (50)         (50)         (58)                                   
      Hyperkeratosis, Focal                            1 (2%)                                                                       
      Hyperplasia, Squamous                                                      1 (2%)                                             
   Stomach, Glandular                                 (59)         (50)         (50)         (58)                                   
      Erosion                                                                                 2 (3%)                                
      Inflammation, Focal, Subacute                                              1 (2%)                                             
   Tooth                                                                                     (1)                                    
      Abscess                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
      Cardiomyopathy                                   2 (3%)       2 (4%)                    1 (2%)                                
      Polyarteritis                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (49)         (49)         (60)                                   
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia                                                                2 (4%)                                             
      Hyperplasia, Focal                              20 (33%)     23 (47%)     21 (43%)     18 (30%)                               
      Hypertrophy                                                                2 (4%)       2 (3%)                                
      Hypertrophy, Focal                              18 (30%)     10 (20%)      4 (8%)      13 (22%)                               
      Necrosis                                                                                1 (2%)                                
      Capsule, Hyperplasia                            53 (88%)     44 (90%)     43 (88%)     48 (80%)                               
      Extra Adrenal Tissue, Necrosis                   1 (2%)                                                                       
   Adrenal Gland                                                   (2)          (2)          (1)                                    
      Corticomedullary Junction, Degeneration                                    1 (50%)      1 (100%)                              
      Corticomedullary Junction, Pigmentation                       2 (100%)     1 (50%)                                            
   Adrenal Medulla                                    (60)         (50)         (49)         (60)                                   
      Degeneration                                     1 (2%)                                                                       
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Focal                                                                      1 (2%)                                
   Islets, Pancreatic                                 (60)         (49)         (50)         (60)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (58)         (47)         (48)         (59)                                   
      Cyst                                             1 (2%)       1 (2%)       1 (2%)       3 (5%)                                
      Pars Distalis, Hyperplasia, Focal                2 (3%)                    1 (2%)                                             
   Thyroid Gland                                      (60)         (50)         (50)         (60)                                   
      Hyperplasia                                                                1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Follicle, Cyst                                                1 (2%)       2 (4%)                                             
      Follicular Cell, Hyperplasia                     7 (12%)      9 (18%)      6 (12%)     13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)                                    (1)                                    
      Inflammation                                     1 (100%)                                                                     
      Inflammation, Suppurative                                                               1 (100%)                              
   Epididymis                                         (60)         (49)         (50)         (60)                                   
      Granuloma Sperm                                  2 (3%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Fat, Necrosis                                                              2 (4%)                                             
      Head, Inflammation, Chronic                                                1 (2%)                                             
   Penis                                              (1)          (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
   Preputial Gland                                    (1)          (1)                       (1)                                    
      Cyst                                                                                    1 (100%)                              
      Dilatation                                       1 (100%)     1 (100%)                                                        
   Prostate                                           (60)         (49)         (50)         (60)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Subacute                           1 (2%)                    1 (2%)       1 (2%)                                
   Seminal Vesicle                                    (60)         (49)         (50)         (60)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Testes                                             (60)         (49)         (50)         (60)                                   
      Atrophy                                                                    1 (2%)                                             
      Giant Cell                                                    2 (4%)                    2 (3%)                                
      Hypospermia                                                                1 (2%)                                             
      Interstitial Cell, Hyperplasia, Focal                         1 (2%)       1 (2%)                                             
      Seminiferous Tubule, Degeneration                2 (3%)       5 (10%)      2 (4%)       5 (8%)                                
      Seminiferous Tubule, Mineralization                           1 (2%)       1 (2%)       1 (2%)                                
      Tunic, Mineralization                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (48)         (50)         (60)                                   
      Sternal, Myelofibrosis                           1 (2%)                                                                       
   Lymph Node, Mesenteric                             (57)         (50)         (47)         (60)                                   
      Congestion                                                    1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                                                   1 (2%)                                
      Sinus, Congestion                                2 (4%)                                                                       
   Spleen                                             (60)         (50)         (50)         (60)                                   
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                45 (75%)     45 (90%)     46 (92%)     47 (78%)                               
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Capsule, Inflammation                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (50)         (50)         (60)                                   
      Acanthosis                                       1 (2%)                                                                       
      Edema                                                                                   1 (2%)                                
      Exudate                                          2 (3%)                                                                       
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Pigmentation, Melanin                            1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Control, Edema                                                             1 (2%)                                             
      Control, Infiltration Cellular, Focal, Mast                                                                                   
          Cell                                                                   1 (2%)                                             
      Head, Exudate                                                 1 (2%)                                                          
      Subcutaneous Tissue, Granuloma                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (48)         (50)         (60)                                   
      Femur, Fracture                                                            1 (2%)                                             
   Skeletal Muscle                                                 (1)          (1)          (1)                                    
      Diaphragm, Inflammation, Chronic                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Hemorrhage                                                    2 (4%)                                                          
      Mineralization, Focal                           50 (83%)     41 (82%)     46 (92%)     49 (82%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05106-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (50)         (60)                                   
      Adenomatosis, Focal                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Congestion                                       1 (2%)       1 (2%)       2 (4%)       6 (10%)                               
      Hemorrhage, Focal                                                                       1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic, Focal                     3 (5%)       1 (2%)       2 (4%)       1 (2%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          2 (3%)                    4 (8%)       6 (10%)                               
      Alveolus, Infiltration Cellular, Histiocyte      2 (3%)       3 (6%)       1 (2%)                                             
      Peribronchial, Hyperplasia, Lymphoid             3 (5%)       2 (4%)       1 (2%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Ulcer                                                                      1 (100%)                                           
   Eye                                                             (1)                                                              
      Cornea, Necrosis                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (50)         (60)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Hyperplasia, Tubular                                                       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Metaplasia, Focal, Osseous                                                 1 (2%)       1 (2%)                                
      Nephropathy                                     49 (82%)     41 (82%)     44 (88%)     44 (73%)                               
      Capsule, Inflammation, Chronic                                             1 (2%)                                             
      Cortex, Atrophy, Focal                                        2 (4%)       1 (2%)       1 (2%)                                
      Cortex, Cyst                                     3 (5%)                    2 (4%)       4 (7%)                                
      Cortex, Metaplasia, Focal, Osseous                            1 (2%)                                                          
      Pelvis, Dilatation                                                         2 (4%)                                             
      Perirenal Tissue, Necrosis                                                 1 (2%)                                             
      Renal Tubule, Mineralization, Focal             47 (78%)     40 (80%)     33 (66%)     38 (63%)                               
   Urinary Bladder                                    (60)         (49)         (50)         (60)                                   
      Hemorrhage, Focal                                                                       1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.