TDMS Study 05106-03 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DIETHYLPHTHALATE
NTP Experiment-Test: 05106-03 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: 03/16/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 9 10 10
Early Deaths
Natural Death 5 8 7 5
Moribund Sacrifice 4 5 5 8
Accidently Killed 1
Survivors
Natural Death 1 1
Terminal Sacrifice 41 37 36 36
Missing 1
Animals Examined Microscopically 60 55 53 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (58) (44) (50) (58)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (57) (44) (49) (57)
Abscess 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Liver (60) (55) (53) (60)
Basophilic Focus 2 (3%) 3 (5%) 6 (11%) 2 (3%)
Clear Cell Focus 2 (3%) 3 (6%) 1 (2%)
Clear Cell Focus, Multiple 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%) 4 (7%) 3 (6%) 3 (5%)
Hematopoietic Cell Proliferation 1 (2%) 3 (5%)
Hepatodiaphragmatic Nodule 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Focal 15 (25%) 13 (24%) 13 (25%) 10 (17%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%) 6 (11%) 3 (6%) 2 (3%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Hypertrophy 1 (2%)
Centrilobular, Necrosis 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%)
Hepatocyte, Hyperplasia, Focal 1 (2%) 1 (2%)
Mesentery (3)
Fat, Necrosis 2 (67%)
Pancreas (59) (51) (50) (59)
Abscess 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Edema 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%)
Polyarteritis 1 (2%)
Duct, Ectasia 1 (2%) 1 (2%)
Salivary Glands (60) (51) (50) (60)
Inflammation, Chronic 1 (2%)
Stomach, Glandular (60) (51) (50) (60)
Erosion 1 (2%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Muscularis, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (51) (50) (60)
Cardiomyopathy 1 (2%) 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Atrium, Thrombosis 1 (2%)
Myocardium, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (51) (50) (60)
Accessory Adrenal Cortical Nodule 1 (2%)
Cyst 2 (3%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%) 5 (10%) 3 (5%)
Hypertrophy, Focal 2 (3%) 2 (4%)
Pigmentation 1 (2%)
Capsule, Hyperplasia 57 (95%) 51 (100%) 50 (100%) 58 (97%)
Adrenal Gland (48) (42) (46) (48)
Corticomedullary Junction, Congestion 5 (10%) 6 (14%) 3 (7%) 7 (15%)
Corticomedullary Junction, Degeneration 41 (85%) 39 (93%) 44 (96%) 46 (96%)
Corticomedullary Junction, Hemorrhage 3 (6%) 3 (7%) 7 (15%) 2 (4%)
Corticomedullary Junction, Pigmentation 13 (27%) 14 (33%) 8 (17%) 13 (27%)
Adrenal Medulla (60) (51) (50) (60)
Hyperplasia, Focal 1 (2%) 1 (2%)
Parathyroid Gland (57) (48) (47) (60)
Cyst 1 (2%) 4 (9%) 1 (2%)
Pituitary Gland (59) (48) (50) (59)
Angiectasis 1 (2%)
Cyst 1 (2%) 2 (4%) 4 (8%)
Pigmentation 1 (2%)
Pars Distalis, Hyperplasia, Focal 4 (7%) 10 (21%) 9 (18%) 9 (15%)
Thyroid Gland (60) (51) (50) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 (2%)
C-Cell, Hyperplasia 5 (8%) 2 (4%) 1 (2%) 2 (3%)
Follicle, Cyst 1 (2%) 4 (8%) 1 (2%)
Follicle, Dilatation 1 (2%)
Follicle, Necrosis 1 (2%)
Follicular Cell, Hyperplasia 9 (15%) 12 (24%) 5 (10%) 8 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (59) (51) (49) (59)
Atrophy 38 (64%) 36 (71%) 42 (86%) 37 (63%)
Congestion 1 (2%)
Cyst 21 (36%) 23 (45%) 20 (41%) 16 (27%)
Cyst Dermoid 1 (2%)
Hematocyst 7 (12%) 16 (31%) 6 (12%) 15 (25%)
Pigmentation 1 (2%) 1 (2%)
Uterus (60) (51) (49) (60)
Dilatation 3 (6%) 2 (4%) 1 (2%)
Endometrium, Hyperplasia, Cystic 59 (98%) 49 (96%) 47 (96%) 60 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (51) (50) (60)
Sternal, Myelofibrosis 45 (75%) 45 (88%) 43 (86%) 46 (77%)
Lymph Node (7) (7) (5) (8)
Hyperplasia, Lymphoid 1 (14%) 1 (13%)
Hemal, Necrosis 1 (14%)
Mediastinal, Pigmentation 1 (13%)
Pancreatic, Hyperplasia, Lymphoid 1 (20%)
Pancreatic, Inflammation, Chronic 1 (14%)
Pancreatic, Lymphatic, Ectasia 1 (13%)
Renal, Pigmentation 1 (13%)
Thoracic, Hyperplasia 1 (14%)
Lymph Node, Mandibular (56) (47) (47) (57)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Lymph Node, Mesenteric (59) (45) (48) (60)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Spleen (60) (51) (50) (60)
Hematopoietic Cell Proliferation 43 (72%) 44 (86%) 47 (94%) 44 (73%)
Hyperplasia, Lymphoid 6 (10%) 1 (2%) 3 (6%) 3 (5%)
Hyperplasia, Reticulum Cell 1 (2%)
Infarct 1 (2%)
Capsule, Fibrosis 1 (2%)
Vein, Dilatation 1 (2%)
Thymus (51) (40) (35) (55)
Hyperplasia, Lymphoid 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (46) (50) (54)
Hyperplasia 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Skin (60) (51) (50) (60)
Acanthosis, Focal 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Edema 1 (2%) 1 (2%)
Exudate 1 (2%)
Control, Edema 1 (2%)
Site of Application-No Mass, Exudate 1 (2%)
Site of Application-No Mass, Ulcer 1 (2%)
Subcutaneous Tissue, Control, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (51) (50) (60)
Vertebra, Fracture 1 (2%)
Skeletal Muscle (1) (1) (1) (4)
Hemorrhage, Focal 1 (100%)
Abdominal, Pigmentation 1 (25%)
Diaphragm, Pigmentation 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (51) (50) (60)
Compression 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (2%)
Mineralization, Focal 42 (70%) 34 (67%) 36 (72%) 35 (58%)
Brain Stem, Hemorrhage 1 (2%)
Spinal Cord (2) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Hemorrhage 1 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (51) (50) (60)
Adenomatosis, Focal 1 (2%) 1 (2%)
Congestion 4 (7%) 5 (10%) 2 (4%) 2 (3%)
Hemorrhage, Focal 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 2 (4%) 1 (2%) 4 (7%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 4 (7%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%) 1 (2%) 3 (5%)
Peribronchial, Hyperplasia, Lymphoid 28 (47%) 15 (29%) 11 (22%) 15 (25%)
Nose (60) (50) (50) (60)
Hemorrhage 1 (2%)
Trachea (60) (51) (50) (60)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Inflammation, Subacute 1 (100%)
Cornea, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (51) (50) (60)
Metaplasia, Focal, Osseous 1 (2%) 1 (2%)
Metaplasia, Osseous 2 (3%)
Nephropathy 9 (15%) 18 (35%) 15 (30%) 10 (17%)
Capsule, Inflammation, Focal 1 (2%)
Cortex, Atrophy, Focal 2 (3%) 4 (8%) 3 (6%) 3 (5%)
Cortex, Cyst 1 (2%) 1 (2%)
Cortex, Metaplasia, Focal, Osseous 1 (2%)
Pelvis, Crystals 1 (2%)
Pelvis, Dilatation 1 (2%) 2 (4%) 1 (2%) 2 (3%)
Proximal Convoluted Renal Tubule,
Cytoplasmic Alteration 2 (4%) 1 (2%)
Renal Tubule, Mineralization, Focal 1 (2%) 2 (4%) 3 (6%) 2 (3%)
Urinary Bladder (59) (47) (49) (58)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 5 4 2 6
Moribund Sacrifice 2 3 2 1
Accidently Killed 1
Survivors
Terminal Sacrifice 43 41 46 43
Missing 1
Animals Examined Microscopically 60 53 51 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (57) (49) (48) (56)
Hyperplasia, Lymphoid 2 (4%)
Intestine Small, Ileum (57) (48) (48) (56)
Congestion 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Liver (60) (53) (51) (60)
Basophilic Focus 1 (2%) 9 (18%) 3 (5%)
Clear Cell Focus 2 (3%) 2 (4%) 2 (4%) 3 (5%)
Clear Cell Focus, Multiple 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 1 (2%) 2 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage, Focal 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 3 (5%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 4 (7%) 1 (2%) 2 (4%) 3 (5%)
Bile Duct, Hyperplasia, Focal 1 (2%)
Centrilobular, Necrosis 1 (2%)
Sinusoid, Dilatation 1 (2%)
Vein, Dilatation 1 (2%)
Mesentery (2) (2) (2)
Hemorrhage 1 (50%)
Fat, Necrosis 2 (100%) 1 (50%) 1 (50%)
Pancreas (60) (49) (50) (60)
Atrophy, Focal 1 (2%)
Cyst 1 (2%)
Edema 1 (2%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hypertrophy, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Duct, Ectasia 1 (2%)
Stomach, Forestomach (60) (50) (50) (58)
Hyperkeratosis, Focal 1 (2%)
Hyperplasia, Squamous 1 (2%)
Stomach, Glandular (59) (50) (50) (58)
Erosion 2 (3%)
Inflammation, Focal, Subacute 1 (2%)
Tooth (1)
Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (50) (60)
Cardiomyopathy 2 (3%) 2 (4%) 1 (2%)
Polyarteritis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (49) (49) (60)
Atrophy 1 (2%)
Hyperplasia 2 (4%)
Hyperplasia, Focal 20 (33%) 23 (47%) 21 (43%) 18 (30%)
Hypertrophy 2 (4%) 2 (3%)
Hypertrophy, Focal 18 (30%) 10 (20%) 4 (8%) 13 (22%)
Necrosis 1 (2%)
Capsule, Hyperplasia 53 (88%) 44 (90%) 43 (88%) 48 (80%)
Extra Adrenal Tissue, Necrosis 1 (2%)
Adrenal Gland (2) (2) (1)
Corticomedullary Junction, Degeneration 1 (50%) 1 (100%)
Corticomedullary Junction, Pigmentation 2 (100%) 1 (50%)
Adrenal Medulla (60) (50) (49) (60)
Degeneration 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (60) (49) (50) (60)
Hyperplasia 1 (2%)
Pituitary Gland (58) (47) (48) (59)
Cyst 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Pars Distalis, Hyperplasia, Focal 2 (3%) 1 (2%)
Thyroid Gland (60) (50) (50) (60)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Inflammation, Chronic, Focal 1 (2%)
Follicle, Cyst 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 7 (12%) 9 (18%) 6 (12%) 13 (22%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1)
Inflammation 1 (100%)
Inflammation, Suppurative 1 (100%)
Epididymis (60) (49) (50) (60)
Granuloma Sperm 2 (3%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Mineralization 1 (2%)
Fat, Necrosis 2 (4%)
Head, Inflammation, Chronic 1 (2%)
Penis (1) (1)
Inflammation, Suppurative 1 (100%)
Preputial Gland (1) (1) (1)
Cyst 1 (100%)
Dilatation 1 (100%) 1 (100%)
Prostate (60) (49) (50) (60)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%) 1 (2%)
Seminal Vesicle (60) (49) (50) (60)
Inflammation, Chronic 1 (2%)
Testes (60) (49) (50) (60)
Atrophy 1 (2%)
Giant Cell 2 (4%) 2 (3%)
Hypospermia 1 (2%)
Interstitial Cell, Hyperplasia, Focal 1 (2%) 1 (2%)
Seminiferous Tubule, Degeneration 2 (3%) 5 (10%) 2 (4%) 5 (8%)
Seminiferous Tubule, Mineralization 1 (2%) 1 (2%) 1 (2%)
Tunic, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (48) (50) (60)
Sternal, Myelofibrosis 1 (2%)
Lymph Node, Mesenteric (57) (50) (47) (60)
Congestion 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Sinus, Congestion 2 (4%)
Spleen (60) (50) (50) (60)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 45 (75%) 45 (90%) 46 (92%) 47 (78%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Capsule, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (50) (50) (60)
Acanthosis 1 (2%)
Edema 1 (2%)
Exudate 2 (3%)
Inflammation, Chronic, Focal 1 (2%)
Pigmentation, Melanin 1 (2%)
Ulcer 1 (2%)
Control, Edema 1 (2%)
Control, Infiltration Cellular, Focal, Mast
Cell 1 (2%)
Head, Exudate 1 (2%)
Subcutaneous Tissue, Granuloma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (48) (50) (60)
Femur, Fracture 1 (2%)
Skeletal Muscle (1) (1) (1)
Diaphragm, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (50) (60)
Hemorrhage 2 (4%)
Mineralization, Focal 50 (83%) 41 (82%) 46 (92%) 49 (82%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05106-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: DERMAL,SOLUTION Time: 21:33:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MICROL 7.5 MICR 15 MICRO 30 MICRO
ITERS OLITERS LITERS LITERS
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (50) (50) (60)
Adenomatosis, Focal 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%) 1 (2%) 2 (4%) 6 (10%)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic, Focal 3 (5%) 1 (2%) 2 (4%) 1 (2%)
Necrosis, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (3%) 4 (8%) 6 (10%)
Alveolus, Infiltration Cellular, Histiocyte 2 (3%) 3 (6%) 1 (2%)
Peribronchial, Hyperplasia, Lymphoid 3 (5%) 2 (4%) 1 (2%) 5 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Ulcer 1 (100%)
Eye (1)
Cornea, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (50) (50) (60)
Amyloid Deposition 1 (2%)
Hyperplasia, Tubular 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Focal, Osseous 1 (2%) 1 (2%)
Nephropathy 49 (82%) 41 (82%) 44 (88%) 44 (73%)
Capsule, Inflammation, Chronic 1 (2%)
Cortex, Atrophy, Focal 2 (4%) 1 (2%) 1 (2%)
Cortex, Cyst 3 (5%) 2 (4%) 4 (7%)
Cortex, Metaplasia, Focal, Osseous 1 (2%)
Pelvis, Dilatation 2 (4%)
Perirenal Tissue, Necrosis 1 (2%)
Renal Tubule, Mineralization, Focal 47 (78%) 40 (80%) 33 (66%) 38 (63%)
Urinary Bladder (60) (49) (50) (60)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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