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TDMS Study 05106-03 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          DIETHYLPHTHALATE


NTP Experiment-Test: 05106-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  03/16/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            8            7            5                                     
    Moribund Sacrifice                                 4            5            5            8                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Natural Death                                                   1            1                                                  
    Terminal Sacrifice                                41           37           36           36                                     
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    60           55           53           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (57)         (41)         (44)         (55)                                   
   Intestine Large, Cecum                             (58)         (45)         (48)         (60)                                   
      Leiomyoma                                                                  1 (2%)                                             
   Intestine Small, Duodenum                          (57)         (45)         (48)         (58)                                   
   Intestine Small, Jejunum                           (58)         (44)         (50)         (58)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (57)         (44)         (49)         (57)                                   
   Liver                                              (60)         (55)         (53)         (60)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Hepatocellular Carcinoma                         4 (7%)       5 (9%)       6 (11%)      3 (5%)                                
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Adenoma                           6 (10%)     10 (18%)     13 (25%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Histiocytic Sarcoma                                           3 (5%)       1 (2%)                                             
   Pancreas                                           (59)         (51)         (50)         (59)                                   
   Salivary Glands                                    (60)         (51)         (50)         (60)                                   
   Stomach, Forestomach                               (60)         (51)         (50)         (59)                                   
      Squamous Cell Carcinoma                                       2 (4%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                 2 (3%)                                
   Tongue                                                                                    (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (51)         (50)         (60)                                   
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (51)         (50)         (60)                                   
      Adenoma                                          2 (3%)                    1 (2%)       1 (2%)                                
      Capsule, Adenoma                                              1 (2%)                                                          
   Adrenal Medulla                                    (60)         (51)         (50)         (60)                                   
      Pheochromocytoma Benign                          4 (7%)                                                                       
   Islets, Pancreatic                                 (60)         (51)         (50)         (59)                                   
      Carcinoma                                        2 (3%)                                                                       
   Pituitary Gland                                    (59)         (48)         (50)         (59)                                   
      Pars Distalis, Adenoma                           6 (10%)      4 (8%)       4 (8%)       1 (2%)                                
   Thyroid Gland                                      (60)         (51)         (50)         (60)                                   
      Follicular Cell, Adenoma                         1 (2%)       5 (10%)      1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (2)          (1)                                    
      Hemangiosarcoma                                  1 (100%)     1 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (51)         (49)         (59)                                   
      Cystadenoma                                      3 (5%)       4 (8%)       2 (4%)       2 (3%)                                
      Granulosa Cell Tumor Malignant                   1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Luteoma                                                                    1 (2%)                                             
      Teratoma Malignant                               1 (2%)                                                                       
   Uterus                                             (60)         (51)         (49)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Polyp                                            3 (5%)                    1 (2%)                                             
      Polyp, Multiple                                               1 (2%)                                                          
      Sarcoma Stromal                                  1 (2%)                                                                       
      Cervix, Histiocytic Sarcoma                                   2 (4%)       1 (2%)                                             
      Cervix, Leiomyosarcoma                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (51)         (50)         (60)                                   
   Lymph Node                                         (7)          (7)          (5)          (8)                                    
      Sarcoma, Metastatic, Tissue NOS                               1 (14%)                                                         
      Axillary, Sarcoma, Metastatic, Tissue NOS                     1 (14%)                                                         
      Mediastinal, Histiocytic Sarcoma                              1 (14%)                                                         
   Lymph Node, Mandibular                             (56)         (47)         (47)         (57)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (59)         (45)         (48)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Spleen                                             (60)         (51)         (50)         (60)                                   
      Hemangiosarcoma                                                            3 (6%)       2 (3%)                                
      Hemangiosarcoma, Multiple                                                               1 (2%)                                
   Thymus                                             (51)         (40)         (35)         (55)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (46)         (50)         (54)                                   
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (60)         (51)         (50)         (60)                                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Abdominal, Mast Cell Tumor Benign                1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       2 (4%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue,                                                                                                          
          Hepatocholangiocarcinoma, Metastatic,                                                                                     
           Liver                                       1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (51)         (50)         (60)                                   
      Vertebra, Osteosarcoma                                                                  1 (2%)                                
   Skeletal Muscle                                    (1)          (1)          (1)          (4)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (51)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (51)         (50)         (60)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     2 (3%)       6 (12%)      4 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       3 (6%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       4 (8%)       3 (6%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Teratoma Malignant, Metastatic                   1 (2%)                                                                       
   Nose                                               (60)         (50)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (1)                                                 
      Fibrosarcoma                                                  1 (100%)     1 (100%)                                           
   Harderian Gland                                    (1)          (1)          (5)                                                 
      Adenocarcinoma                                                             1 (20%)                                            
      Adenoma                                          1 (100%)     1 (100%)     4 (80%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (50)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Ureter                                             (1)          (1)                                                              
   Urinary Bladder                                    (59)         (47)         (49)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(55)        *(53)        *(60)                                   
      Histiocytic Sarcoma                                           3 (5%)       1 (2%)                                             
      Leukemia Lymphocytic                             1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   2 (3%)       3 (5%)       2 (4%)       2 (3%)                                
      Lymphoma Malignant Mixed                         5 (8%)       8 (15%)      5 (9%)       6 (10%)                               
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          41          38          31                                       
     Total Primary Neoplasms                           55          69          62          42                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          26          26          17                                       
     Total Benign Neoplasms                            32          34          33          20                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          27          23          20                                       
     Total Malignant Neoplasms                         23          35          29          22                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           5           5           2                                       
     Total Metastatic Neoplasm                          8           6           5           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            4            2            6                                     
    Moribund Sacrifice                                 2            3            2            1                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           41           46           43                                     
  Missing                                                           1                                                               
  Animals Examined Microscopically                    60           53           51           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (57)         (49)         (48)         (56)                                   
   Intestine Small, Jejunum                           (57)         (49)         (48)         (56)                                   
   Intestine Small, Ileum                             (57)         (48)         (48)         (56)                                   
   Liver                                              (60)         (53)         (51)         (60)                                   
      Adenoma, Multiple                                1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Hemangiosarcoma, Multiple                        1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma                         3 (5%)       3 (6%)       5 (10%)      5 (8%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)       1 (2%)       3 (5%)                                
      Hepatocellular Adenoma                           6 (10%)     11 (21%)      7 (14%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)       2 (4%)       3 (6%)       4 (7%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (2)          (2)          (2)                                                 
      Hemangioma                                                    1 (50%)                                                         
   Pancreas                                           (60)         (49)         (50)         (60)                                   
      Acinus, Carcinoma                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (49)         (49)         (60)                                   
      Adenoma                                          6 (10%)      3 (6%)       2 (4%)       2 (3%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Capsule, Adenoma                                 3 (5%)       2 (4%)                    2 (3%)                                
   Adrenal Medulla                                    (60)         (50)         (49)         (60)                                   
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Pituitary Gland                                    (58)         (47)         (48)         (59)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
   Thyroid Gland                                      (60)         (50)         (50)         (60)                                   
      Follicular Cell, Adenoma                         2 (3%)       1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)          (1)          (2)          (1)                                    
      Hemangioma                                                                              1 (100%)                              
      Lipoma                                           1 (33%)                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (49)         (50)         (60)                                   
      Sarcoma                                          1 (2%)                                                                       
   Penis                                              (1)          (1)                                                              
   Prostate                                           (60)         (49)         (50)         (60)                                   
   Testes                                             (60)         (49)         (50)         (60)                                   
      Interstitial Cell, Adenoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (2)          (1)                       (1)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (50%)                                                                      
   Lymph Node, Mandibular                             (53)         (47)         (47)         (59)                                   
   Lymph Node, Mesenteric                             (57)         (50)         (47)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Spleen                                             (60)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                  4 (7%)                    5 (10%)      1 (2%)                                
      Hemangiosarcoma, Multiple                        2 (3%)                                 1 (2%)                                
   Thymus                                             (39)         (39)         (37)         (41)                                   
      Hemangiosarcoma                                  1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Paraganglioma Benign        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (48)         (50)         (60)                                   
      Vertebra, Osteosarcoma                                                     1 (2%)                                             
   Skeletal Muscle                                                 (1)          (1)          (1)                                    
      Diaphragm, Carcinoma, Metastatic, Pancreas                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (50)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     6 (10%)      1 (2%)       6 (12%)      6 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   5 (8%)       5 (10%)      4 (8%)       3 (5%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Carcinoma, Metastatic, Liver                                                            1 (2%)                                
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       2 (4%)       2 (4%)       4 (7%)                                
   Nose                                               (60)         (49)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (2)          (3)                                                 
      Adenoma                                          1 (100%)     2 (100%)     3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (50)         (60)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(53)        *(51)        *(60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)                    1 (2%)                                
      Lymphoma Malignant Mixed                         2 (3%)       2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05106-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 21:33:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MICROL     7.5 MICR     15 MICRO     30 MICRO                                  
                                                   ITERS        OLITERS      LITERS       LITERS                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          28          34          32                                       
     Total Primary Neoplasms                           52          40          45          45                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 19          20          24          23                                       
     Total Benign Neoplasms                            28          25          28          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          14          15          17                                       
     Total Malignant Neoplasms                         24          15          17          19                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           2           5                                       
     Total Metastatic Neoplasm                          2           5           2           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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