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TDMS Study 05106-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Hazelton, MD                                           DIETHYLPHTHALATE                                   DATE: 05/19/95       
EXPERIMENT: 05106 TEST: 03                                                                                     TIME: 21:47:27       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-45036                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60048B       
PATHOLOGIST: R. CARDY                        S. EUSTIS                                                         CAS: 84-66-2         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Hazelton, MD                                           DIETHYLPHTHALATE                                   DATE: 05/19/95       
EXPERIMENT: 05106 TEST: 03                                                                                     TIME: 21:47:27       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-45036                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60048B       
PATHOLOGIST: R. CARDY                        S. EUSTIS                                                         CAS: 84-66-2         


                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Gland
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Hazelton, MD                                           DIETHYLPHTHALATE                                   DATE: 05/19/95       
EXPERIMENT: 05106 TEST: 03                                                                                     TIME: 21:47:27       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-45036                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60048B       
PATHOLOGIST: R. CARDY                        S. EUSTIS                                                         CAS: 84-66-2         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF DIETHYLPHTHALATE
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Cortex                Adenoma
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Spleen                        Hemangiosarcoma
              All Organs                    Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                             Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
                                            Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous Tumor
                                             (malignant or NOS), or Carcinoma
              Spleen                        Hemangiosarcoma
              Thyroid Gland: Follicular Cell
                                            Carcinoma or Adenoma
              Uterus                        Sarcoma Stromal or Polyp Stromal
              All Organs                    Malignant Lymphoma And Histiocytic Sarcoma
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   1
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)   5/49 (10%)   2/49 (4%)    4/60 (7%)  |  2/60 (3%)    1/51 (2%)    1/50 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  18.6%        12.2%         4.4%         9.3%      |   4.9%         2.6%         2.7%         2.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  8/43 (19%)   5/41 (12%)   2/45 (4%)    4/43 (9%)  |  2/41 (5%)    1/38 (3%)    1/37 (3%)    1/36 (3%)  |
|FIRST INCIDENCE (DAYS) |   730 (T)      730 (T)      730 (T)      730 (T)   |   730 (T)      730 (T)      730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.110N     P=0.306N     P=0.040N*    P=0.177N   |  P=0.449N     P=0.527N     P=0.536N     P=0.545N   |
|INCIDENTAL TUMOR       |  P=0.110N     P=0.306N     P=0.040N*    P=0.177N   |  P=0.449N     P=0.527N     P=0.536N     P=0.545N   |
|LOGISTIC REGRESSION    |  P=0.110N     P=0.306N     P=0.040N*    P=0.177N   |  P=0.449N     P=0.527N     P=0.536N     P=0.545N   |
|COCHRAN-ARMITAGE       |  P=0.114N                                          |  P=0.401N                                          |
|FISHER EXACT           |               P=0.422N     P=0.089N     P=0.181N   |               P=0.561N     P=0.569N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/50 (0%)    1/49 (2%)    0/60 (0%)  |  4/60 (7%)    0/51 (0%)    0/50 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.2%         0.0%      |   9.3%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    1/45 (2%)    0/43 (0%)  |  3/41 (7%)    0/38 (0%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          730 (T)      ---       |   662          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.697        (e)        P=0.509        (e)      |  P=0.026N*    P=0.076N     P=0.081N     P=0.082N   |
|INCIDENTAL TUMOR       |  P=0.697        (e)        P=0.509        (e)      |  P=0.021N*    P=0.079N     P=0.082N     P=0.063N   |
|LOGISTIC REGRESSION    |  P=0.697        (e)        P=0.509        (e)      |  P=0.023N*    P=0.076N     P=0.078N     P=0.069N   |
|COCHRAN-ARMITAGE       |  P=0.692                                           |  P=0.023N*                                         |
|FISHER EXACT           |                 (e)        P=0.450        (e)      |               P=0.081N     P=0.084N     P=0.059N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   2
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/53 (4%)    3/51 (6%)    0/60 (0%)  |  1/60 (2%)    1/55 (2%)    4/53 (8%)    0/60 (0%)  |
|ADJUSTED (b)           |   1.7%         4.4%         6.5%         0.0%      |   2.4%         2.6%        10.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    3/46 (7%)    0/43 (0%)  |  1/41 (2%)    1/38 (3%)    4/37 (11%)   0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   450 (I)      590          730 (T)      ---       |   730 (T)      730 (T)      730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.327N     P=0.361      P=0.171      P=0.500N   |  P=0.488N     P=0.745      P=0.150      P=0.526N   |
|INCIDENTAL TUMOR       |  P=0.341N     P=0.362      P=0.171      P=0.500N   |  P=0.488N     P=0.745      P=0.150      P=0.526N   |
|LOGISTIC REGRESSION    |  P=0.329N     P=0.514      P=0.166      P=0.535N   |  P=0.488N     P=0.745      P=0.150      P=0.526N   |
|COCHRAN-ARMITAGE       |  P=0.334N                                          |  P=0.440N                                          |
|FISHER EXACT           |               P=0.453      P=0.250      P=0.500N   |               P=0.730      P=0.146      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/53 (4%)    3/51 (6%)    0/60 (0%)  |  1/60 (2%)    1/55 (2%)    5/53 (9%)    0/60 (0%)  |
|ADJUSTED (b)           |   1.7%         4.4%         6.5%         0.0%      |   2.4%         2.6%        13.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    3/46 (7%)    0/43 (0%)  |  1/41 (2%)    1/38 (3%)    5/37 (14%)   0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   450 (I)      590          730 (T)      ---       |   730 (T)      730 (T)      730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.327N     P=0.361      P=0.171      P=0.500N   |  P=0.522N     P=0.745      P=0.081      P=0.526N   |
|INCIDENTAL TUMOR       |  P=0.341N     P=0.362      P=0.171      P=0.500N   |  P=0.522N     P=0.745      P=0.081      P=0.526N   |
|LOGISTIC REGRESSION    |  P=0.329N     P=0.514      P=0.166      P=0.535N   |  P=0.522N     P=0.745      P=0.081      P=0.526N   |
|COCHRAN-ARMITAGE       |  P=0.334N                                          |  P=0.469N                                          |
|FISHER EXACT           |               P=0.453      P=0.250      P=0.500N   |               P=0.730      P=0.077      P=0.500N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   3
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/49 (0%)    0/50 (0%)    0/60 (0%)  |  2/60 (3%)    0/51 (0%)    0/50 (0%)    0/59 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.9%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/40 (0%)    0/46 (0%)    0/43 (0%)  |  2/41 (5%)    0/38 (0%)    0/37 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.129N     P=0.255N     P=0.261N     P=0.274N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.129N     P=0.255N     P=0.261N     P=0.274N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.129N     P=0.255N     P=0.261N     P=0.274N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.121N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.290N     P=0.295N     P=0.252N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/53 (2%)    0/51 (0%)    2/60 (3%)  |  0/60 (0%)    1/55 (2%)    1/53 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.1%         2.4%         0.0%         4.7%      |   0.0%         2.6%         2.6%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    1/41 (2%)    0/46 (0%)    2/43 (5%)  |  0/41 (0%)    1/38 (3%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   558          730 (T)      ---          730 (T)   |   ---          730 (T)      675          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.373      P=0.750      P=0.492N     P=0.500    |  P=0.611N     P=0.485      P=0.476        (e)      |
|INCIDENTAL TUMOR       |  P=0.368      P=0.755      P=0.718N     P=0.500    |  P=0.550N     P=0.485      P=0.464        (e)      |
|LOGISTIC REGRESSION    |  P=0.378      P=0.737      P=0.752N     P=0.500    |  P=0.597N     P=0.485      P=0.476        (e)      |
|COCHRAN-ARMITAGE       |  P=0.377                                           |  P=0.590N                                          |
|FISHER EXACT           |               P=0.720      P=0.541N     P=0.500    |               P=0.478      P=0.469        (e)      |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   4
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)  13/53 (25%)  10/51 (20%)  14/60 (23%) |  7/60 (12%)  12/55 (22%)  14/53 (26%)  11/60 (18%) |
|ADJUSTED (b)           |  15.4%        29.1%        21.1%        30.3%      |  14.3%        30.6%        35.5%        26.1%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/3 (67%)    1/1 (100%)   2/10 (20%) |  3/10 (30%)   0/4 (0%)     0/3 (0%)     1/10 (10%) |
|TERMINAL (d)           |  6/43 (14%)  10/41 (24%)   9/46 (20%)  12/43 (28%) |  4/41 (10%)  11/38 (29%)  12/37 (32%)   7/36 (19%) |
|FIRST INCIDENCE (DAYS) |   450 (I)      450 (I)      450 (I)      450 (I)   |   450 (I)      675          586          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.141      P=0.039 *    P=0.194      P=0.073    |  P=0.189      P=0.067      P=0.018 *    P=0.171    |
|INCIDENTAL TUMOR       |  P=0.139      P=0.040 *    P=0.194      P=0.073    |  P=0.243      P=0.065      P=0.023 *    P=0.273    |
|LOGISTIC REGRESSION    |  P=0.127      P=0.062      P=0.197      P=0.076    |  P=0.249      P=0.114      P=0.040 *    P=0.227    |
|COCHRAN-ARMITAGE       |  P=0.125                                           |  P=0.267                                           |
|FISHER EXACT           |               P=0.062      P=0.186      P=0.074    |               P=0.113      P=0.038 *    P=0.222    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    4/53 (8%)    6/51 (12%)   8/60 (13%) |  4/60 (7%)    5/55 (9%)    6/53 (11%)   4/60 (7%)  |
|ADJUSTED (b)           |   9.0%         8.9%        12.8%        16.0%      |   8.8%        11.7%        14.4%         8.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     1/10 (10%) |  0/10 (0%)    0/4 (0%)     0/3 (0%)     1/10 (10%) |
|TERMINAL (d)           |  3/43 (7%)    1/41 (2%)    5/46 (11%)   3/43 (7%)  |  2/41 (5%)    2/38 (5%)    2/37 (5%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   635          576          714          450 (I)   |   591          560          644          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.121      P=0.616      P=0.414      P=0.195    |  P=0.540      P=0.449      P=0.313      P=0.604    |
|INCIDENTAL TUMOR       |  P=0.109      P=0.637      P=0.366      P=0.178    |  P=0.433N     P=0.592      P=0.473      P=0.581N   |
|LOGISTIC REGRESSION    |  P=0.108      P=0.575      P=0.375      P=0.173    |  P=0.464N     P=0.533      P=0.457      P=0.566N   |
|COCHRAN-ARMITAGE       |  P=0.113                                           |  P=0.537N                                          |
|FISHER EXACT           |               P=0.570      P=0.273      P=0.181    |               P=0.445      P=0.295      P=0.641N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   5
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)  16/53 (30%)  15/51 (29%)  20/60 (33%) | 10/60 (17%)  16/55 (29%)  19/53 (36%)  14/60 (23%) |
|ADJUSTED (b)           |  21.7%        34.5%        31.2%        40.1%      |  20.1%        37.8%        45.0%        31.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/3 (67%)    1/1 (100%)   2/10 (20%) |  3/10 (30%)   0/4 (0%)     0/3 (0%)     2/10 (20%) |
|TERMINAL (d)           |  8/43 (19%)  11/41 (27%)  13/46 (28%)  14/43 (33%) |  5/41 (12%)  12/38 (32%)  14/37 (38%)   7/36 (19%) |
|FIRST INCIDENCE (DAYS) |   450 (I)      450 (I)      450 (I)      450 (I)   |   450 (I)      560          586          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.055      P=0.058      P=0.131      P=0.035 *  |  P=0.220      P=0.061      P=0.012 *    P=0.195    |
|INCIDENTAL TUMOR       |  P=0.052      P=0.054      P=0.112      P=0.030 *  |  P=0.316      P=0.070      P=0.021 *    P=0.323    |
|LOGISTIC REGRESSION    |  P=0.044 *    P=0.070      P=0.113      P=0.030 *  |  P=0.288      P=0.086      P=0.018 *    P=0.255    |
|COCHRAN-ARMITAGE       |  P=0.043 *                                         |  P=0.300                                           |
|FISHER EXACT           |               P=0.069      P=0.085      P=0.028 *  |               P=0.086      P=0.017 *    P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)  16/53 (30%)  15/51 (29%)  20/60 (33%) | 10/60 (17%)  16/55 (29%)  19/53 (36%)  14/60 (23%) |
|ADJUSTED (b)           |  21.7%        34.5%        31.2%        40.1%      |  20.1%        37.8%        45.0%        31.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/3 (67%)    1/1 (100%)   2/10 (20%) |  3/10 (30%)   0/4 (0%)     0/3 (0%)     2/10 (20%) |
|TERMINAL (d)           |  8/43 (19%)  11/41 (27%)  13/46 (28%)  14/43 (33%) |  5/41 (12%)  12/38 (32%)  14/37 (38%)   7/36 (19%) |
|FIRST INCIDENCE (DAYS) |   450 (I)      450 (I)      450 (I)      450 (I)   |   450 (I)      560          586          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.055      P=0.058      P=0.131      P=0.035 *  |  P=0.220      P=0.061      P=0.012 *    P=0.195    |
|INCIDENTAL TUMOR       |  P=0.052      P=0.054      P=0.112      P=0.030 *  |  P=0.316      P=0.070      P=0.021 *    P=0.323    |
|LOGISTIC REGRESSION    |  P=0.044 *    P=0.070      P=0.113      P=0.030 *  |  P=0.288      P=0.086      P=0.018 *    P=0.255    |
|COCHRAN-ARMITAGE       |  P=0.043 *                                         |  P=0.300                                           |
|FISHER EXACT           |               P=0.069      P=0.085      P=0.028 *  |               P=0.086      P=0.017 *    P=0.247    |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   6
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   2/50 (4%)    7/50 (14%)   7/60 (12%) |  2/60 (3%)    6/51 (12%)   4/50 (8%)    1/60 (2%)  |
|ADJUSTED (b)           |  13.1%         4.9%        14.9%        15.4%      |   4.9%        15.0%        10.0%         2.8%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/0          0/0          1/10 (10%) |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  5/43 (12%)   2/41 (5%)    6/46 (13%)   6/43 (14%) |  2/41 (5%)    5/38 (13%)   3/37 (8%)    1/36 (3%)  |
|FIRST INCIDENCE (DAYS) |   450 (I)      730 (T)      714          450 (I)   |   730 (T)      560          521          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.291      P=0.236N     P=0.428      P=0.500    |  P=0.280N     P=0.114      P=0.298      P=0.545N   |
|INCIDENTAL TUMOR       |  P=0.304      P=0.236N     P=0.448      P=0.500    |  P=0.249N     P=0.130      P=0.453      P=0.545N   |
|LOGISTIC REGRESSION    |  P=0.278      P=0.188N     P=0.433      P=0.503    |  P=0.239N     P=0.102      P=0.272      P=0.545N   |
|COCHRAN-ARMITAGE       |  P=0.279                                           |  P=0.228N                                          |
|FISHER EXACT           |               P=0.203N     P=0.361      P=0.500    |               P=0.089      P=0.257      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    6/50 (12%)   4/50 (8%)    3/60 (5%)  |  2/60 (3%)    3/51 (6%)    2/50 (4%)    1/60 (2%)  |
|ADJUSTED (b)           |  11.6%        14.6%         8.7%         7.0%      |   4.8%         6.5%         4.9%         2.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  5/43 (12%)   6/41 (15%)   4/46 (9%)    3/43 (7%)  |  1/41 (2%)    0/38 (0%)    1/37 (3%)    1/36 (3%)  |
|FIRST INCIDENCE (DAYS) |   730 (T)      730 (T)      730 (T)      730 (T)   |   727          481          632          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.212N     P=0.466      P=0.458N     P=0.356N   |  P=0.341N     P=0.474      P=0.656      P=0.548N   |
|INCIDENTAL TUMOR       |  P=0.212N     P=0.466      P=0.458N     P=0.356N   |  P=0.211N     P=0.552N     P=0.653N     P=0.484N   |
|LOGISTIC REGRESSION    |  P=0.212N     P=0.466      P=0.458N     P=0.356N   |  P=0.300N     P=0.390      P=0.649      P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.216N                                          |  P=0.306N                                          |
|FISHER EXACT           |               P=0.373      P=0.615N     P=0.359N   |               P=0.423      P=0.619      P=0.500N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   7
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/60 (15%)   7/50 (14%)  10/50 (20%)  10/60 (17%) |  4/60 (7%)    9/51 (18%)   6/50 (12%)   2/60 (3%)  |
|ADJUSTED (b)           |  20.0%        17.1%        21.3%        22.2%      |   9.5%        20.6%        14.7%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/0          0/0          1/10 (10%) |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  8/43 (19%)   7/41 (17%)   9/46 (20%)   9/43 (21%) |  3/41 (7%)    5/38 (13%)   4/37 (11%)   2/36 (6%)  |
|FIRST INCIDENCE (DAYS) |   450 (I)      730 (T)      714          450 (I)   |   727          481          521          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.401      P=0.540N     P=0.459      P=0.500    |  P=0.192N     P=0.102      P=0.317      P=0.401N   |
|INCIDENTAL TUMOR       |  P=0.413      P=0.540N     P=0.477      P=0.500    |  P=0.111N     P=0.235      P=0.497      P=0.357N   |
|LOGISTIC REGRESSION    |  P=0.396      P=0.484N     P=0.470      P=0.507    |  P=0.145N     P=0.067      P=0.286      P=0.394N   |
|COCHRAN-ARMITAGE       |  P=0.398                                           |  P=0.142N                                          |
|FISHER EXACT           |               P=0.551N     P=0.330      P=0.500    |               P=0.067      P=0.262      P=0.340N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  3/59 (5%)    4/51 (8%)    2/49 (4%)    2/59 (3%)  |
|ADJUSTED (b)           |                                                    |   7.5%        10.5%         5.4%         5.4%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |                                                    |  3/40 (8%)    4/38 (11%)   2/37 (5%)    1/36 (3%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   730 (T)      730 (T)      730 (T)      725       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.365N     P=0.472      P=0.536N     P=0.550N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.339N     P=0.472      P=0.536N     P=0.502N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.359N     P=0.472      P=0.536N     P=0.540N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.312N                                          |
|FISHER EXACT           |                                                    |               P=0.419      P=0.588N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   8
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)    0/47 (0%)    0/48 (0%)    0/59 (0%)  |  6/59 (10%)   4/48 (8%)    4/50 (8%)    1/59 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  13.9%        10.6%        10.0%         2.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  0/42 (0%)    0/38 (0%)    0/45 (0%)    0/42 (0%)  |  4/41 (10%)   3/36 (8%)    3/37 (8%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   675          682          521          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.068N     P=0.445N     P=0.436N     P=0.088N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.036N*    P=0.427N     P=0.283N     P=0.049N*  |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.050N*    P=0.237N     P=0.440N     P=0.069N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.046N*                                         |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.508N     P=0.480N     P=0.057N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  0/60 (0%)    0/55 (0%)    0/53 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  0/41 (0%)    0/38 (0%)    0/37 (0%)    2/36 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.040 *      (e)          (e)        P=0.210    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.040 *      (e)          (e)        P=0.210    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.040 *      (e)          (e)        P=0.210    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.051                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)          (e)        P=0.248    |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE   9
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  1/60 (2%)    5/55 (9%)    0/53 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%        11.2%         0.0%         4.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  1/41 (2%)    2/38 (5%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      365          ---          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.524N     P=0.094      P=0.520N     P=0.475    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.439N     P=0.196      P=0.520N     P=0.531    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.485N     P=0.082      P=0.520N     P=0.498    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.493N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.084      P=0.531N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  1/60 (2%)    2/55 (4%)    0/53 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%         4.7%         0.0%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  1/41 (2%)    1/38 (3%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      509          ---          648       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.524N     P=0.478      P=0.520N     P=0.736    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.425N     P=0.745      P=0.520N     P=0.732N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.493N     P=0.469      P=0.520N     P=0.758    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.495N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.467      P=0.531N     P=0.752N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  10
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  1/60 (2%)    5/55 (9%)    0/53 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%        11.2%         0.0%         4.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  1/41 (2%)    2/38 (5%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      365          ---          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.524N     P=0.094      P=0.520N     P=0.475    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.439N     P=0.196      P=0.520N     P=0.531    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.485N     P=0.082      P=0.520N     P=0.498    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.493N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.084      P=0.531N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  0/60 (0%)    0/55 (0%)    0/53 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.3%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/43 (2%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  0/41 (0%)    0/38 (0%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   536          ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.113N     P=0.252N     P=0.230N     P=0.240N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.173N     P=0.245N     P=0.487N     P=0.314N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.126N     P=0.261N     P=0.354N     P=0.240N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.120N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.280N     P=0.290N     P=0.248N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  11
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  0/60 (0%)    2/55 (4%)    0/53 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         4.2%         0.0%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  0/41 (0%)    0/38 (0%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          365          ---          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.537      P=0.225        (e)        P=0.500    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.563      P=0.290        (e)        P=0.500    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.550      P=0.197        (e)        P=0.503    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.542                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.227        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous Tumor                                                           |
|     (malignant or NOS), or Carcinoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  0/60 (0%)    0/55 (0%)    0/53 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  0/41 (0%)    0/38 (0%)    0/37 (0%)    2/36 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.040 *      (e)          (e)        P=0.210    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.040 *      (e)          (e)        P=0.210    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.040 *      (e)          (e)        P=0.210    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.051                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)          (e)        P=0.248    |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  12
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   0/50 (0%)    5/50 (10%)   2/60 (3%)  |  0/60 (0%)    0/51 (0%)    3/50 (6%)    3/60 (5%)  |
|ADJUSTED (b)           |  13.4%         0.0%        10.3%         4.4%      |   0.0%         0.0%         7.8%         6.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  5/43 (12%)   0/41 (0%)    3/46 (7%)    1/43 (2%)  |  0/41 (0%)    0/38 (0%)    2/37 (5%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   536          ---          663          675       |   ---          ---          675          645       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.225N     P=0.022N*    P=0.455N     P=0.138N   |  P=0.032 *      (e)        P=0.105      P=0.113    |
|INCIDENTAL TUMOR       |  P=0.212N     P=0.021N*    P=0.544N     P=0.148N   |  P=0.068        (e)        P=0.101      P=0.186    |
|LOGISTIC REGRESSION    |  P=0.221N     P=0.027N*    P=0.584N     P=0.133N   |  P=0.040 *      (e)        P=0.101      P=0.120    |
|COCHRAN-ARMITAGE       |  P=0.226N                                          |  P=0.042 *                                         |
|FISHER EXACT           |               P=0.023N*    P=0.627N     P=0.136N   |                 (e)        P=0.091      P=0.122    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  0/60 (0%)    2/55 (4%)    0/53 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         5.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  0/41 (0%)    2/38 (5%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          730 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.430N     P=0.222        (e)          (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.430N     P=0.222        (e)          (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.430N     P=0.222        (e)          (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.404N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.227        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  13
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  1/60 (2%)    2/55 (4%)    0/53 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%         5.3%         0.0%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  1/41 (2%)    2/38 (5%)    0/37 (0%)    2/36 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      730 (T)      ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.429      P=0.473      P=0.520N     P=0.455    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.429      P=0.473      P=0.520N     P=0.455    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.429      P=0.473      P=0.520N     P=0.455    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.475                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.467      P=0.531N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  1/60 (2%)    0/55 (0%)    0/53 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%         0.0%         0.0%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  1/41 (2%)    0/38 (0%)    0/37 (0%)    2/36 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      ---          ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.221      P=0.515N     P=0.520N     P=0.455    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.221      P=0.515N     P=0.520N     P=0.455    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.221      P=0.515N     P=0.520N     P=0.455    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.254                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.522N     P=0.531N     P=0.500    |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  14
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/50 (2%)    3/50 (6%)    0/60 (0%)  |  1/60 (2%)    5/51 (10%)   1/50 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.4%         2.4%         6.5%         0.0%      |   2.3%        12.8%         2.7%         2.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  1/43 (2%)    1/41 (2%)    3/46 (7%)    0/43 (0%)  |  0/41 (0%)    4/38 (11%)   1/37 (3%)    1/36 (3%)  |
|FIRST INCIDENCE (DAYS) |   558          730 (T)      730 (T)      ---       |   675          718          730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.236N     P=0.516N     P=0.528      P=0.240N   |  P=0.358N     P=0.091      P=0.735      P=0.741    |
|INCIDENTAL TUMOR       |  P=0.244N     P=0.511N     P=0.432      P=0.240N   |  P=0.301N     P=0.080      P=0.728      P=0.732N   |
|LOGISTIC REGRESSION    |  P=0.235N     P=0.564N     P=0.418      P=0.239N   |  P=0.332N     P=0.083      P=0.734      P=0.755    |
|COCHRAN-ARMITAGE       |  P=0.239N                                          |  P=0.306N                                          |
|FISHER EXACT           |               P=0.569N     P=0.414      P=0.248N   |               P=0.070      P=0.705      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/50 (2%)    3/50 (6%)    0/60 (0%)  |  1/60 (2%)    6/51 (12%)   1/50 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.4%         2.4%         6.5%         0.0%      |   2.3%        15.4%         2.7%         2.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/0          0/0          0/10 (0%)  |  0/10 (0%)    0/0          0/0          0/10 (0%)  |
|TERMINAL (d)           |  1/43 (2%)    1/41 (2%)    3/46 (7%)    0/43 (0%)  |  0/41 (0%)    5/38 (13%)   1/37 (3%)    1/36 (3%)  |
|FIRST INCIDENCE (DAYS) |   558          730 (T)      730 (T)      ---       |   675          718          730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.236N     P=0.516N     P=0.528      P=0.240N   |  P=0.308N     P=0.050      P=0.735      P=0.741    |
|INCIDENTAL TUMOR       |  P=0.244N     P=0.511N     P=0.432      P=0.240N   |  P=0.259N     P=0.043 *    P=0.728      P=0.732N   |
|LOGISTIC REGRESSION    |  P=0.235N     P=0.564N     P=0.418      P=0.239N   |  P=0.283N     P=0.044 *    P=0.734      P=0.755    |
|COCHRAN-ARMITAGE       |  P=0.239N                                          |  P=0.258N                                          |
|FISHER EXACT           |               P=0.569N     P=0.414      P=0.248N   |               P=0.035 *    P=0.705      P=0.752N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  15
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tissue NOS                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/53 (0%)    0/51 (0%)    0/60 (0%)  |  1/60 (2%)    1/55 (2%)    2/53 (4%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%         2.6%         5.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  1/41 (2%)    1/38 (3%)    1/37 (3%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      730 (T)      675          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.396N     P=0.745      P=0.462      P=0.526N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.358N     P=0.745      P=0.455      P=0.526N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.378N     P=0.745      P=0.466      P=0.526N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.365N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.730      P=0.453      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  3/60 (5%)    1/55 (2%)    1/53 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   6.6%         2.6%         2.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/41 (2%)    1/38 (3%)    1/37 (3%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   662          730 (T)      730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.088N     P=0.334N     P=0.352N     P=0.143N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.064N     P=0.351N     P=0.356N     P=0.081N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.078N     P=0.335N     P=0.343N     P=0.124N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.076N                                          |
|FISHER EXACT           |                                                    |               P=0.343N     P=0.357N     P=0.122N   |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  16
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  4/60 (7%)    1/55 (2%)    1/53 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   8.7%         2.6%         2.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/41 (2%)    1/38 (3%)    1/37 (3%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   662          730 (T)      730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.044N*    P=0.207N     P=0.224N     P=0.081N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.026N*    P=0.214N     P=0.218N     P=0.029N*  |
|LOGISTIC REGRESSION    |                                                    |  P=0.037N*    P=0.206N     P=0.214N     P=0.065N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.037N*                                         |
|FISHER EXACT           |                                                    |               P=0.210N     P=0.223N     P=0.059N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)   1/53 (2%)    6/51 (12%)   4/60 (7%)  |  1/60 (2%)    2/55 (4%)    4/53 (8%)    4/60 (7%)  |
|ADJUSTED (b)           |  21.9%         2.4%        12.1%         9.0%      |   2.4%         5.3%        10.5%         9.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  8/43 (19%)   1/41 (2%)    3/46 (7%)    3/43 (7%)  |  1/41 (2%)    2/38 (5%)    3/37 (8%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   536          730 (T)      633          675       |   730 (T)      730 (T)      675          645       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.140N     P=0.008N**   P=0.179N     P=0.080N   |  P=0.100      P=0.473      P=0.151      P=0.164    |
|INCIDENTAL TUMOR       |  P=0.138N     P=0.007N**   P=0.306N     P=0.085N   |  P=0.166      P=0.473      P=0.148      P=0.264    |
|LOGISTIC REGRESSION    |  P=0.128N     P=0.009N**   P=0.288N     P=0.075N   |  P=0.113      P=0.473      P=0.150      P=0.175    |
|COCHRAN-ARMITAGE       |  P=0.145N                                          |  P=0.124                                           |
|FISHER EXACT           |               P=0.007N**   P=0.324N     P=0.077N   |               P=0.467      P=0.146      P=0.182    |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  17
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)   2/53 (4%)    6/51 (12%)   5/60 (8%)  |  2/60 (3%)    2/55 (4%)    4/53 (8%)    4/60 (7%)  |
|ADJUSTED (b)           |  21.9%         4.9%        12.1%        11.3%      |   4.9%         5.3%        10.5%         9.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  8/43 (19%)   2/41 (5%)    3/46 (7%)    4/43 (9%)  |  2/41 (5%)    2/38 (5%)    3/37 (8%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   536          730 (T)      633          675       |   730 (T)      730 (T)      675          645       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.206N     P=0.021N*    P=0.179N     P=0.137N   |  P=0.184      P=0.667      P=0.291      P=0.305    |
|INCIDENTAL TUMOR       |  P=0.204N     P=0.020N*    P=0.306N     P=0.144N   |  P=0.275      P=0.667      P=0.287      P=0.441    |
|LOGISTIC REGRESSION    |  P=0.192N     P=0.025N*    P=0.288N     P=0.130N   |  P=0.206      P=0.667      P=0.290      P=0.327    |
|COCHRAN-ARMITAGE       |  P=0.211N                                          |  P=0.223                                           |
|FISHER EXACT           |               P=0.025N*    P=0.324N     P=0.135N   |               P=0.657      P=0.282      P=0.340    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/53 (2%)    0/51 (0%)    0/60 (0%)  |  0/60 (0%)    3/55 (5%)    1/53 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         2.0%         0.0%         0.0%      |   0.0%         7.2%         2.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  0/10 (0%)    0/4 (0%)     0/3 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/43 (0%)    0/41 (0%)    0/46 (0%)    0/43 (0%)  |  0/41 (0%)    2/38 (5%)    0/37 (0%)    0/36 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          378          ---          ---       |   ---          484          586          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.560N     P=0.468        (e)          (e)      |  P=0.387N     P=0.113      P=0.483        (e)      |
|INCIDENTAL TUMOR       |  P=0.707N     P=0.500        (e)          (e)      |  P=0.321N     P=0.222      P=0.682        (e)      |
|LOGISTIC REGRESSION    |  P=0.658N     P=0.629        (e)          (e)      |  P=0.361N     P=0.105      P=0.463        (e)      |
|COCHRAN-ARMITAGE       |  P=0.562N                                          |  P=0.365N                                          |
|FISHER EXACT           |               P=0.469        (e)          (e)      |               P=0.106      P=0.469        (e)      |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  18
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/53 (8%)    0/51 (0%)    3/60 (5%)  |  7/60 (12%)  15/55 (27%)   9/53 (17%)   8/60 (13%) |
|ADJUSTED (b)           |   7.0%         8.4%         0.0%         6.7%      |  15.2%        34.1%        20.9%        18.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  1/10 (10%)   0/4 (0%)     0/3 (0%)     1/10 (10%) |
|TERMINAL (d)           |  3/43 (7%)    1/41 (2%)    0/46 (0%)    1/43 (2%)  |  4/41 (10%)  10/38 (26%)   4/37 (11%)   3/36 (8%)  |
|FIRST INCIDENCE (DAYS) |   730 (T)      378          ---          698       |   450 (I)      273          568          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.444N     P=0.456      P=0.110N     P=0.659N   |  P=0.472N     P=0.031 *    P=0.271      P=0.424    |
|INCIDENTAL TUMOR       |  P=0.480N     P=0.485      P=0.110N     P=0.603N   |  P=0.307N     P=0.050      P=0.330      P=0.561    |
|LOGISTIC REGRESSION    |  P=0.459N     P=0.445      P=0.110N     P=0.659N   |  P=0.386N     P=0.030 *    P=0.429      P=0.492    |
|COCHRAN-ARMITAGE       |  P=0.446N                                          |  P=0.382N                                          |
|FISHER EXACT           |               P=0.431      P=0.154N     P=0.660N   |               P=0.029 *    P=0.295      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/53 (6%)    0/51 (0%)    3/60 (5%)  |  7/60 (12%)  13/55 (24%)   8/53 (15%)   8/60 (13%) |
|ADJUSTED (b)           |   7.0%         6.6%         0.0%         6.7%      |  15.2%        30.3%        19.1%        18.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     0/10 (0%)  |  1/10 (10%)   0/4 (0%)     0/3 (0%)     1/10 (10%) |
|TERMINAL (d)           |  3/43 (7%)    1/41 (2%)    0/46 (0%)    1/43 (2%)  |  4/41 (10%)   9/38 (24%)   4/37 (11%)   3/36 (8%)  |
|FIRST INCIDENCE (DAYS) |   730 (T)      397          ---          698       |   450 (I)      273          568          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.510N     P=0.628      P=0.110N     P=0.659N   |  P=0.525N     P=0.072      P=0.363      P=0.424    |
|INCIDENTAL TUMOR       |  P=0.499N     P=0.646      P=0.110N     P=0.603N   |  P=0.373N     P=0.078      P=0.388      P=0.561    |
|LOGISTIC REGRESSION    |  P=0.511N     P=0.604      P=0.110N     P=0.659N   |  P=0.446N     P=0.075      P=0.407      P=0.492    |
|COCHRAN-ARMITAGE       |  P=0.512N                                          |  P=0.437N                                          |
|FISHER EXACT           |               P=0.600      P=0.154N     P=0.660N   |               P=0.074      P=0.397      P=0.500    |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  19
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 19/60 (32%)  20/53 (38%)  24/51 (47%)  23/60 (38%) | 24/60 (40%)  26/55 (47%)  26/53 (49%)  17/60 (28%) |
|ADJUSTED (b)           |  39.5%        43.1%        49.9%        49.2%      |  48.1%        61.8%        62.9%        40.5%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   2/3 (67%)    1/1 (100%)   3/10 (30%) |  4/10 (40%)   0/4 (0%)     0/3 (0%)     1/10 (10%) |
|TERMINAL (d)           | 15/43 (35%)  15/41 (37%)  22/46 (48%)  20/43 (47%) | 16/41 (39%)  22/38 (58%)  22/37 (59%)  12/36 (33%) |
|FIRST INCIDENCE (DAYS) |   450 (I)      450 (I)      450 (I)      450 (I)   |   450 (I)      560          521          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.282      P=0.247      P=0.115      P=0.280    |  P=0.169N     P=0.210      P=0.156      P=0.240N   |
|INCIDENTAL TUMOR       |  P=0.281      P=0.241      P=0.101      P=0.280    |  P=0.078N     P=0.185      P=0.235      P=0.097N   |
|LOGISTIC REGRESSION    |  P=0.263      P=0.318      P=0.095      P=0.287    |  P=0.080N     P=0.278      P=0.240      P=0.133N   |
|COCHRAN-ARMITAGE       |  P=0.254                                           |  P=0.070N                                          |
|FISHER EXACT           |               P=0.316      P=0.072      P=0.283    |               P=0.275      P=0.218      P=0.124N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 19/60 (32%)  14/53 (26%)  15/51 (29%)  17/60 (28%) | 18/60 (30%)  27/55 (49%)  23/53 (43%)  20/60 (33%) |
|ADJUSTED (b)           |  41.1%        29.5%        30.0%        33.8%      |  35.4%        53.7%        47.8%        39.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/3 (0%)     0/1 (0%)     1/10 (10%) |  1/10 (10%)   0/4 (0%)     0/3 (0%)     2/10 (20%) |
|TERMINAL (d)           | 16/43 (37%)   8/41 (20%)  11/46 (24%)  10/43 (23%) |  9/41 (22%)  15/38 (39%)  12/37 (32%)   6/36 (17%) |
|FIRST INCIDENCE (DAYS) |   536          378          633          450 (I)   |   193          273          393          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.433N     P=0.273N     P=0.209N     P=0.420N   |  P=0.458      P=0.050      P=0.131      P=0.330    |
|INCIDENTAL TUMOR       |  P=0.440N     P=0.229N     P=0.331N     P=0.395N   |  P=0.268N     P=0.121      P=0.277      P=0.517N   |
|LOGISTIC REGRESSION    |  P=0.388N     P=0.337N     P=0.304N     P=0.371N   |  P=0.465N     P=0.027 *    P=0.098      P=0.424    |
|COCHRAN-ARMITAGE       |  P=0.438N                                          |  P=0.472N                                          |
|FISHER EXACT           |               P=0.343N     P=0.481N     P=0.421N   |               P=0.028 *    P=0.100      P=0.422    |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05106 TEST: 03                                                 PAGE  20
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIETHYLPHTHALATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |   0 MICROL     7.5 MICR     15 MICRO     30 MICRO  |
|                       |   ITERS        OLITERS      LITERS       LITERS    |   ITERS        OLITERS      LITERS       LITERS    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/60 (50%)  28/53 (53%)  34/51 (67%)  32/60 (53%) | 36/60 (60%)  41/55 (75%)  38/53 (72%)  31/60 (52%) |
|ADJUSTED (b)           |  60.6%        55.9%        66.7%        61.2%      |  65.1%        81.9%        77.5%        60.4%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   2/3 (67%)    1/1 (100%)   3/10 (30%) |  5/10 (50%)   0/4 (0%)     0/3 (0%)     3/10 (30%) |
|TERMINAL (d)           | 24/43 (56%)  19/41 (46%)  29/46 (63%)  23/43 (53%) | 22/41 (54%)  29/38 (76%)  26/37 (70%)  16/36 (44%) |
|FIRST INCIDENCE (DAYS) |   450 (I)      378          450 (I)      450 (I)   |   193          273          393          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.398      P=0.427      P=0.217      P=0.438    |  P=0.303N     P=0.087      P=0.131      P=0.449N   |
|INCIDENTAL TUMOR       |  P=0.368      P=0.445      P=0.100      P=0.446    |  P=0.047N*    P=0.198      P=0.323      P=0.136N   |
|LOGISTIC REGRESSION    |  P=0.365      P=0.456      P=0.106      P=0.437    |  P=0.095N     P=0.073      P=0.141      P=0.238N   |
|COCHRAN-ARMITAGE       |  P=0.351                                           |  P=0.089N                                          |
|FISHER EXACT           |               P=0.456      P=0.057      P=0.428    |               P=0.072      P=0.134      P=0.231N   |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   450
          Female interim sacrifices(days): 450
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.