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TDMS Study 05106-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          DIETHYLPHTHALATE


NTP Experiment-Test: 05106-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: SKIN APPLICATION                                                                                           Time: 20:47:32




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           12           17                                                  
    Natural Death                                      9           10           10                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           28           21                                                  
    Natural Death                                                                2                                                  
  Animals Examined Microscopically                    60           52           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (58)         (47)         (58)                                                
   Liver                                              (59)         (52)         (60)                                                
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
   Mesentery                                          (3)          (3)          (1)                                                 
   Pancreas                                           (59)         (50)         (60)                                                
      Adenoma                                                                    1 (2%)                                             
   Salivary Glands                                    (59)         (50)         (60)                                                
   Stomach, Forestomach                               (59)         (50)         (60)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (59)         (50)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (51)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (60)                                                
      Adenoma                                          4 (7%)       4 (8%)       6 (10%)                                            
      Adenoma, Multiple                                                          1 (2%)                                             
   Adrenal Gland, Medulla                             (58)         (50)         (60)                                                
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)                                                          
      Pheochromocytoma Benign                          3 (5%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          3 (6%)       1 (2%)       3 (6%)                                             
      Carcinoma                                        2 (4%)       3 (6%)                                                          
   Parathyroid Gland                                  (54)         (50)         (57)                                                
      Adenoma                                                                    1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (59)         (50)         (58)                                                
      Pars Distalis, Adenoma                          42 (71%)     33 (66%)     35 (60%)                                            
      Pars Distalis, Carcinoma                         2 (3%)       2 (4%)       1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (59)         (50)         (60)                                                
      Adenoma                                          1 (2%)                                                                       
      C-Cell, Adenoma                                                            1 (2%)                                             
      C-Cell, Carcinoma                                6 (10%)      5 (10%)      2 (3%)                                             
      Follicular Cell, Carcinoma                       3 (5%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (2)          (2)                                                 
      Basosquamous Tumor Malignant                                  1 (50%)                                                         
      Fibrosarcoma                                     1 (50%)                                                                      
      Sarcoma                                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (39)         (50)                                                
      Adenoma                                          5 (9%)                    2 (4%)                                             
      Carcinoma                                        2 (4%)       1 (3%)       2 (4%)                                             
   Ovary                                              (59)         (50)         (60)                                                
      Carcinoma                                                                  1 (2%)                                             
   Uterus                                             (59)         (50)         (60)                                                
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                    2 (3%)       3 (6%)       6 (10%)                                            
      Sarcoma Stromal                                                            1 (2%)                                             
      Schwannoma Malignant                             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (59)         (50)         (60)                                                
   Lymph Node, Mandibular                             (59)         (50)         (60)                                                
   Lymph Node, Mesenteric                             (59)         (50)         (60)                                                
   Spleen                                             (60)         (52)         (60)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
   Thymus                                             (53)         (43)         (52)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (49)         (60)                                                
      Adenocarcinoma                                   5 (8%)       3 (6%)       3 (5%)                                             
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                    22 (37%)     11 (22%)      7 (12%)                                            
      Fibroadenoma, Multiple                           1 (2%)       1 (2%)                                                          
      Fibroma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (57)         (49)         (60)                                                
      Osteosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (50)         (60)                                                
      Carcinoma, Metastatic                            1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (50)         (60)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
   Trachea                                            (59)         (50)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)          (1)                                                 
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (60)                                                
      Carcinoma                                                     1 (2%)                                                          
   Urinary Bladder                                    (57)         (47)         (59)                                                
      Papilloma                                        1 (2%)                    1 (2%)                                             
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(52)        *(60)                                                
      Leukemia Monocytic                               1 (2%)                                                                       
      Leukemia Mononuclear                            18 (30%)     15 (29%)     17 (28%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            58          48          49                                                   
     Total Primary Neoplasms                          133          90          98                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 53          41          41                                                   
     Total Benign Neoplasms                            88          55          68                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          27          24                                                   
     Total Malignant Neoplasms                         45          35          30                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2                                                               
     Total Metastatic Neoplasm                          1           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10            9                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           38           26                                                  
    Natural Death                                     15            6           19                                                  
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                                            
    Terminal Sacrifice                                 3            6            6                                                  
  Animals Examined Microscopically                    60           56           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (51)         (47)         (53)                                                
      Adenocarcinoma                                                             2 (4%)                                             
   Liver                                              (60)         (50)         (60)                                                
      Hepatocellular Adenoma                           1 (2%)                    1 (2%)                                             
   Mesentery                                          (4)          (3)          (1)                                                 
   Pancreas                                           (60)         (50)         (59)                                                
      Fibrosarcoma                                                  1 (2%)                                                          
      Acinus, Adenoma                                  1 (2%)                                                                       
   Pharynx                                                         (1)                                                              
      Papilloma                                                     1 (100%)                                                        
   Salivary Glands                                    (58)         (50)         (59)                                                
      Fibrosarcoma                                                  1 (2%)                                                          
   Stomach, Forestomach                               (59)         (50)         (59)                                                
      Squamous Cell Papilloma                          2 (3%)       2 (4%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (50)         (59)                                                
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (59)         (50)         (57)                                                
      Pheochromocytoma Malignant                                    1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                         15 (25%)      8 (16%)      8 (14%)                                            
      Pheochromocytoma Benign, Multiple                             1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (49)                                                
                                                             Page   7                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                          7 (14%)     10 (20%)      7 (14%)                                            
      Adenoma, Multiple                                             1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
   Parathyroid Gland                                  (57)         (49)         (57)                                                
      Carcinoma, Metastatic                                                      1 (2%)                                             
   Pituitary Gland                                    (54)         (49)         (58)                                                
      Pars Distalis, Adenoma                          43 (80%)     41 (84%)     46 (79%)                                            
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (58)         (50)         (57)                                                
      C-Cell, Adenoma                                  3 (5%)       2 (4%)       2 (4%)                                             
      C-Cell, Carcinoma                                             1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (3)          (2)                                                 
      Fibroma                                                                    1 (50%)                                            
      Fibrosarcoma                                     1 (25%)      1 (33%)                                                         
      Hemangiosarcoma                                  1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)         (48)         (59)                                                
   Preputial Gland                                    (44)         (46)         (54)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)                                             
   Prostate                                           (58)         (50)         (58)                                                
   Seminal Vesicle                                    (58)         (50)         (58)                                                
   Testes                                             (60)         (50)         (59)                                                
      Bilateral, Interstitial Cell, Adenoma                                      1 (2%)                                             
      Interstitial Cell, Adenoma                       4 (7%)       3 (6%)       8 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (49)         (57)                                                
   Lymph Node                                         (60)         (50)         (59)                                                
      Mediastinal, Carcinoma, Metastatic                            1 (2%)                                                          
   Lymph Node, Mandibular                             (58)         (50)         (58)                                                
   Lymph Node, Mesenteric                             (54)         (50)         (55)                                                
   Spleen                                             (60)         (50)         (59)                                                
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (45)         (37)         (44)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (38)         (52)                                                
      Fibroadenoma                                                  1 (3%)                                                          
      Fibroma                                          2 (4%)       1 (3%)                                                          
      Sarcoma                                                       1 (3%)                                                          
   Skin                                               (59)         (56)         (60)                                                
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Face, Papilloma                                                            1 (2%)                                             
      Lip, Papilloma                                                             1 (2%)                                             
      Other, Fibroma                                                1 (2%)                                                          
      Site of Application-Mass, Adenoma                             1 (2%)                                                          
      Thoracic, Keratoacanthoma                                                  1 (2%)                                             
   Skin, Site of Application-No Mass                  (60)         (55)         (60)                                                
      Basal Cell Adenoma                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (59)                                                
      Astrocytoma Malignant                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (60)                                                
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Carcinoma, Metastatic                                         1 (2%)                                                          
   Nose                                               (60)         (50)         (58)                                                
      Adenoma                                                                    1 (2%)                                             
      Carcinoma, Metastatic                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (3)                                                 
      Papilloma                                                     1 (50%)      2 (67%)                                            
   Zymbal's Gland                                                  (3)                                                              
      Carcinoma                                                     1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (60)                                                
      Lipoma                                           1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       1 (2%)                                             
   Urethra                                            (1)                                                                           
      Transitional Epithelium, Carcinoma               1 (100%)                                                                     
   Urinary Bladder                                    (58)         (50)         (56)                                                
      Carcinoma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(56)        *(60)                                                
      Leukemia Mononuclear                             9 (15%)     12 (21%)     13 (22%)                                            
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Mesothelioma Benign                              2 (3%)                                                                       
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05106-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            52          49          55                                                   
     Total Primary Neoplasms                          102         101         109                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 51          47          52                                                   
     Total Benign Neoplasms                            85          78          85                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          21          23                                                   
     Total Malignant Neoplasms                         17          23          24                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                                   
     Total Metastatic Neoplasm                                      3           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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