National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1849

TDMS Study 05107-06 Pathology Tables

NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:13:12

                                                          69 Week SSAC




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     01/18/90 - 01/18/90

       Treatment Groups:       Include All


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:13:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |     A      |
    0.0MG/M3                               | 1| 1| 2| 2| 3| 4| 4| 5|                                                  |     L      |
    LUNG TOX                               | 1| 3| 2| 6| 3| 0| 3| 7|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    M  +  +  +     +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +                                                      |   5        |
      Hemangioma                           |                   X                                                      |          1 |
      Hepatocellular Adenoma               |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M  +  +     I                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     M                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  M     +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    M  +  +  +     +                                                      |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:13:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |     A      |
    0.0MG/M3                               | 1| 1| 2| 2| 3| 4| 4| 5|                                                  |     L      |
    LUNG TOX                               | 1| 3| 2| 6| 3| 0| 3| 7|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  M  M  M     M                                                      |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +  M  +     +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +     +                                                      |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +     +                                                      |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:13:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|                                            |     A      |
    0.6MG/M3                               | 5| 5| 6| 6| 7| 8| 8| 8| 1| 1|                                            |     L      |
    LUNG TOX                               | 2| 9| 0| 5| 0| 2| 7| 9| 6| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +     M                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  M  M     +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M     M  M  M     M                                                      |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:13:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|                                            |     A      |
    0.6MG/M3                               | 5| 5| 6| 6| 7| 8| 8| 8| 1| 1|                                            |     L      |
    LUNG TOX                               | 2| 9| 0| 5| 0| 2| 7| 9| 6| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +     M                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +     +                                                      |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +     +                                                      |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +     +                                                      |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +     +                                                      |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:13:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |     A      |
    1.2MG/M3                               | 0| 0| 1| 2| 3| 4| 6| 7|                                                  |     L      |
    LUNG TOX                               | 4| 5| 1| 8| 1| 9| 9| 2|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  M  +  +     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +     +                                                   |   5        |
      Hemangiosarcoma                      |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M  +  +  +     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  +  M  +     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  +  +     +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:13:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |     A      |
    1.2MG/M3                               | 0| 0| 1| 2| 3| 4| 6| 7|                                                  |     L      |
    LUNG TOX                               | 4| 5| 1| 8| 1| 9| 9| 2|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       M  +  M  M     M                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +  +  +  +     M                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +  +     +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +  +  +  +     +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.