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TDMS Study 05107-05 Pathology Tables

NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15

                                                          Core Animals




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  09/30/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 5| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 7| 6| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 1| 7| 1| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 6| 3| 1| 3| 7| 3| 3| 3| 6| 3|             
                                           | 0| 0| 7| 8| 3| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 3| 2| 3| 1| 4| 0| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|             
                                           | 1| 2| 3| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X     X  X        X           X  X        X           X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma NOS                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                X                                 |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |       X              X        X  X  X           X  X     X              X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 5| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 7| 6| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 1| 7| 1| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 6| 3| 1| 3| 7| 3| 3| 3| 6| 3|             
                                           | 0| 0| 7| 8| 3| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 3| 2| 3| 1| 4| 0| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|             
                                           | 1| 2| 3| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                      X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                       X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                    +  +                              |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                   X                    X  X                              |             
      Renal, Leukemia Mononuclear          |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X           X           X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X        X           X  X        X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  +  M  +  +  I  +  +  +  +  +  I  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                    X  X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X     X  X        X           X  X  X     X           X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                               X                                          |             
      Fibroadenoma                         | X  X        X  X     X              X     X              X              X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pinna, Fibrosarcoma                  |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 5| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 7| 6| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 1| 7| 1| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 6| 3| 1| 3| 7| 3| 3| 3| 6| 3|             
                                           | 0| 0| 7| 8| 3| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 3| 2| 3| 1| 4| 0| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    0.0MG/M3                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|             
                                           | 1| 2| 3| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                X                                                         |             
      Leukemia Mononuclear                 |       X  X     X  X        X           X  X        X           X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Nephroblastoma                       |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X     X  X        X           X  X  X     X           X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6| 7| 7| 5| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9| 2| 2| 7| 2| 7|             
                                           | 0| 1| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6| 9| 9| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 2| 3| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  M  I  +  +  +  +  +  I  +  M  +  +  +  M  +  M  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X        X                       X     X  X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X        X               |             
      Schwannoma NOS                       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Pheochromocytoma Malignant           |                            X                                             |             
      Pheochromocytoma Benign              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X        X               |             
      Pars Distalis, Adenoma               |       X  X        X        X  X  X  X  X  X  X              X        X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X              X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6| 7| 7| 5| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9| 2| 2| 7| 2| 7|             
                                           | 0| 1| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6| 9| 9| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 2| 3| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X           X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +                       +|             
      Iliac, Leukemia Mononuclear          |                                                 X                        |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                         X                       X     X  X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X        X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X        X                       X     X  X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         | X        X     X  X     X     X  X        X        X              X  X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pinna, Fibrosarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6| 7| 7| 5| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9| 2| 2| 7| 2| 7|             
                                           | 0| 1| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6| 9| 9| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 2| 3| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |    X  X     X           X                       X     X  X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Nephroblastoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X        X                       X     X  X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 3|                                                                 |            |
                                           | 1| 7| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0.0MG/M3                               | 3| 3| 4|                                                                 |     L      |
                                           | 5| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         18 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Schwannoma NOS                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               | X     X                                                                  |         24 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Adenoma                      |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 3|                                                                 |            |
                                           | 1| 7| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0.0MG/M3                               | 3| 3| 4|                                                                 |     L      |
                                           | 5| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Granulosa Cell Tumor Benign          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Polyp Stromal                        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  44        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  46        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         | X  X                                                                     |         22 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Pinna, Fibrosarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 3|                                                                 |            |
                                           | 1| 7| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0.0MG/M3                               | 3| 3| 4|                                                                 |     L      |
                                           | 5| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         16 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Nephroblastoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         19 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1| 3|             
                                           | 0| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 1| 2| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  M  +  +  +  +  +  I  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X        X           X  X  X           X     X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Squamous Cell Carcinoma     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Schwannoma NOS                       |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X  X                           |             
      Pheochromocytoma Benign              |                            X     X           X        X                  |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X        X  X  X  X  X                    X     X  X     X  X        X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X                                               X   |             
      C-Cell, Carcinoma                    |                                        X                       X         |             
      Follicular Cell, Carcinoma           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                         +|             
      Mediastinum, Leukemia Mononuclear    |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1| 3|             
                                           | 0| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 1| 2| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Lung                |                                                                         X|             
      Thoracic, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Lung                |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa-Theca Tumor Benign         |          X                                                               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Polyp Stromal                        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                      +   |             
      Schwannoma Malignant                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X        X           X  X  X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                    X     X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                          X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                          X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                    X     X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X        X           X  X  X           X     X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                       X                  |             
      Fibroadenoma                         | X  X                       X        X                 X  X        X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1| 3|             
                                           | 0| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
    MG/M3                                  | 1| 2| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Tooth                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Tooth                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                       X                        |             
      Leukemia Mononuclear                 |                      X  X     X           X  X  X                        |             
      Squamous Cell Carcinoma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X  X     X           X  X  X           X     X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 4| 3| 2| 5| 0| 2| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9| 8| 0| 7| 2| 6| 9|             
                                           | 9| 1| 7| 2| 6| 9| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5| 1| 9| 8| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 3| 4| 5| 6| 7| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  A  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X           X  X  X                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
      Gingiva, Squamous Cell Carcinoma     |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X                                                |             
      Schwannoma NOS                       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pheochromocytoma Benign              |             X                                      X                     |             
      Bilateral, Pheochromocytoma Benign   |                            X                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pars Distalis, Adenoma               | X           X  X  X     X  X     X     X  X     X     X  X     X  X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                 X        X               |             
      C-Cell, Carcinoma                    |                            X                                             |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Mediastinum, Leukemia Mononuclear    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 4| 3| 2| 5| 0| 2| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9| 8| 0| 7| 2| 6| 9|             
                                           | 9| 1| 7| 2| 6| 9| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5| 1| 9| 8| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 3| 4| 5| 6| 7| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Lung                |                                                                          |             
      Thoracic, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Lung                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                                |             
      Carcinoma                            |                                  X        X              X               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa-Theca Tumor Benign         |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
      Polyp Stromal                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +              +                                                |             
      Inguinal, Leukemia Mononuclear       |                         X                                                |             
      Pancreatic, Leukemia Mononuclear     |          X                                                               |             
      Renal, Leukemia Mononuclear          |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |       X  X              X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X  X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X              X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X           X  X  X                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                         X|             
      Fibroadenoma                         |       X     X                          X                    X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 4| 3| 2| 5| 0| 2| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9| 8| 0| 7| 2| 6| 9|             
                                           | 9| 1| 7| 2| 6| 9| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5| 1| 9| 8| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 3| 4| 5| 6| 7| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Tooth                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Tooth                           |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                             X            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                   X     X                           |             
      Leukemia Mononuclear                 |          X              X                                                |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X           X  X  X                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 3| 3|                                                                 |            |
                                           | 8| 5| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 7| 7| 8|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  M                                                                  |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Gingiva, Squamous Cell Carcinoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Schwannoma NOS                       |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pheochromocytoma Benign              |                                                                          |          6 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +                                                                  |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X     X                                                                  |         30 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |                                                                          |          4 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 3| 3|                                                                 |            |
                                           | 8| 5| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 7| 7| 8|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Mediastinum, Leukemia Mononuclear    |                                                                          |          1 |
      Mediastinum, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Lung                |                                                                          |          1 |
      Thoracic, Squamous Cell Carcinoma,   |                                                                          |            |
           Metastatic, Lung                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Granulosa-Theca Tumor Benign         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   3        |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +                                                                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  I  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  I  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  18                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 3| 3|                                                                 |            |
                                           | 8| 5| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 7| 7| 8|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Carcinoma                            | X                                                                        |          3 |
      Fibroadenoma                         |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Fibrosarcoma                         |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Tooth                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Tooth                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Astrocytoma NOS                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  19                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 3| 3|                                                                 |            |
                                           | 8| 5| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 7| 7| 8|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |         18 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  20                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|             
                                           | 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X     X  X           X  X     X           X  X              X     X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X     X           X              X                       X  X            |             
      Bilateral, Pheochromocytoma Benign   |    X     X     X     X     X        X     X     X  X           X  X     X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               |                   X     X  X     X  X  X  X     X                    X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |       X              X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|             
                                           | 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Polyp Stromal                        |                         X                             X  X               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X              X                                            X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +           +                    +                 +     +      |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |       X              X                    X                       X      |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X                    X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X                                   X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 | X     X              X        X           X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X     X              X        X           X  X                    X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|             
                                           | 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X     X  X           X  X     X           X  X              X     X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                            X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         | X                 X        X        X                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Keratoacanthoma                      |                                                             X            |             
      Pinna, Fibrosarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |             
      Alveolar/Bronchiolar Carcinoma       |                X                                X              X         |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                      X                                                   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X                                            X                    X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X              X        X                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  23                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 3| 2| 4| 3| 3| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6| 3| 2| 0| 3|             
                                           | 3| 2| 3| 1| 9| 1| 1| 5| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3| 1| 9| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/M3                                  | 1| 2| 4| 6| 7| 8| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X     X  X           X  X     X           X  X              X     X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  24                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|             
                                           | 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    MG/M3                                  | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  I  M  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X                 X        X  X        X  X     X                 X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X        X                          X     X|             
      Pheochromocytoma Malignant           | X                                                                        |             
      Pheochromocytoma Benign              | X  X                 X                             X           X         |             
      Bilateral, Pheochromocytoma Benign   |       X                 X  X     X  X  X  X           X     X     X     X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                          X     X|             
      Pars Distalis, Adenoma               | X                       X        X              X                       X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      C-Cell, Adenoma                      |                         X           X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  25                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|             
                                           | 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    MG/M3                                  | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Polyp Stromal                        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                        X                          X     X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +        +                                +|             
      Axillary, Leukemia Mononuclear       |                               X                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                        X                                 |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                        X                                 |             
      Inguinal, Leukemia Mononuclear       |                               X                                          |             
      Pancreatic, Leukemia Mononuclear     |                               X        X                                X|             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Leukemia Mononuclear          |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X        X                                X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                            X  X        X                          X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X  X        X  X     X                       X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  +  +  I  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X        X                                X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|             
                                           | 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    MG/M3                                  | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X                 X     X  X  X        X  X     X                 X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X        X                                X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |       X                 X           X  X           X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Pinna, Fibrosarcoma                  |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                             X        X                           |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X        X                          X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                               X        X                          X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 3| 8| 2| 2| 3| 3| 6|             
                                           | 9| 0| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 1| 1| 9| 9| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    MG/M3                                  | 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X                 X     X  X  X        X  X     X                 X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 9| 8| 2|                                                                 |            |
                                           | 4| 2| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1.0                                    | 1| 1| 1|                                                                 |     L      |
    MG/M3                                  | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  M                                                                  |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         21 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          6 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |    X                                                                     |         12 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |         24 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  29                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 9| 8| 2|                                                                 |            |
                                           | 4| 2| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1.0                                    | 1| 1| 1|                                                                 |     L      |
    MG/M3                                  | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pars Distalis, Adenoma               |       X                                                                  |         15 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Adenoma                      |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Thoracic, Alveolar/Bronchiolar       |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Cystadenoma                          |                                                                          |          1 |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Polyp Stromal                        |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |  10        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Histiocytic Sarcoma           |    X                                                                     |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          7 |
      Renal, Histiocytic Sarcoma           |    X                                                                     |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  50        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  30                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 9| 8| 2|                                                                 |            |
                                           | 4| 2| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1.0                                    | 1| 1| 1|                                                                 |     L      |
    MG/M3                                  | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  47        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         22 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Fibroadenoma                         | X                                                                        |         10 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Pinna, Fibrosarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         | X                                                                        |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  31                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 9| 8| 2|                                                                 |            |
                                           | 4| 2| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1.0                                    | 1| 1| 1|                                                                 |     L      |
    MG/M3                                  | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         22 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  32                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|             
                             DAY ON TEST   | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|             
                                           | 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
                                           | 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  I  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                          X               |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |       X        X     X  X  X     X  X  X        X     X  X  X  X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                            X                          X     X            |             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
      Squamous Cell Papilloma              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X           X        X              X         |             
      Mesothelioma NOS                     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                    X              X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|             
                             DAY ON TEST   | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|             
                                           | 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
                                           | 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                      X                 X                                X|             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                                                  |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                                             |             
      Pars Distalis, Adenoma               |    X     X  X  X                          X        X              X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      C-Cell, Adenoma                      |             X     X                                                      |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +              +            |             
      Mediastinum, Leukemia Mononuclear    |                                                             X            |             
      Thoracic, Fibrosarcoma               |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +        +  +     +  +     +  +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|       X           X     X  X     X  X  X        X     X  X  X  X  X     X|             
      Interstitial Cell, Adenoma           |          X                    X           X                              |             
      Tunic, Mesothelioma NOS              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X     X        X  X              X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
      Axillary, Leukemia Mononuclear       |                                                             X            |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|             
                             DAY ON TEST   | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|             
                                           | 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
                                           | 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                             X            |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                    X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                    X     X  X  X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                    X     X  X  X  X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |                      X     X                          X     X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X  X  X     X  X  X        X     X  X  X  X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  I  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                                          |             
      Fibroma                              |                               X                                          |             
      Keratoacanthoma                      |       X                    X        X                                    |             
      Squamous Cell Papilloma              |                                                                          |             
      Pinna, Keratoacanthoma               |                                                                          |             
      Pinna, Squamous Cell Papilloma       |                                                                   X      |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                                                            |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Tail, Fibroma                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Astrocytoma Benign                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  I  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 5| 5| 5| 7| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 6| 6| 7| 2| 7|             
                             DAY ON TEST   | 6| 0| 3| 7| 9| 6| 3| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 8| 3| 5| 0|             
                                           | 1| 8| 6| 8| 4| 5| 3| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 7| 3| 6| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
                                           | 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                                          |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |       X        X     X  X  X        X  X        X     X  X  X  X        X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +              +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X     X                          X  X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |       X        X  X  X  X  X     X  X  X        X     X  X  X  X        X|             
      Mesothelioma NOS                     |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|             
                             DAY ON TEST   | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|             
                                           | 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |             X  X                                X                        |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X              X  X     X     X  X  X  X  X  X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Leukemia Mononuclear                 |                                     X        X        X                  |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X        X     X  X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X        X                  |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X        X        X  X  X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|             
                             DAY ON TEST   | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|             
                                           | 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Complex             |                      X                                                   |             
      Pheochromocytoma Benign              | X  X        X     X                    X  X  X           X     X         |             
      Bilateral, Pheochromocytoma Benign   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X        X     X  X                  |             
      Pars Distalis, Adenoma               |          X     X        X        X     X        X     X     X  X     X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |             X                                         X                  |             
      C-Cell, Carcinoma                    |                                           X                    X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Leukemia Mononuclear    |                                                                          |             
      Thoracic, Fibrosarcoma               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +     +  +  +  +  +  +  +  +     +     +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                      X                                      X            |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X     X        X        X  X              X  X  X  X  X     X|             
      Interstitial Cell, Adenoma           |    X                 X  X     X  X        X  X     X                     |             
      Tunic, Mesothelioma NOS              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X        X     X  X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +  +        +                  |             
      Axillary, Leukemia Mononuclear       |                                              X                           |             
      Iliac, Leukemia Mononuclear          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|             
                             DAY ON TEST   | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|             
                                           | 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                              X        X                  |             
      Renal, Leukemia Mononuclear          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X     X        X  X  X  X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                               X     X        X     X  X  X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X              X  X     X  X  X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                     X        X        X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X              X  X     X     X  X  X  X  X  X  X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Leukemia Mononuclear                 |             X                       X        X     X  X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                             X            |             
      Fibroma                              |                                           X                              |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                               X                                          |             
      Pinna, Keratoacanthoma               |                X                                                         |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                        X                                 |             
      Tail, Fibroma                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteosarcoma                |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
      Astrocytoma Benign                   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 5| 7| 5| 7| 5| 6| 6| 5| 7| 6| 7| 6| 7| 6| 5| 5| 7| 6| 6| 7| 5| 7|             
                             DAY ON TEST   | 5| 1| 9| 2| 1| 7| 3| 5| 3| 7| 4| 3| 7| 3| 9| 0| 3| 7| 9| 3| 3| 5| 3| 3| 3|             
                                           | 9| 5| 9| 1| 3| 4| 3| 3| 4| 8| 2| 3| 1| 7| 9| 1| 5| 2| 6| 7| 9| 1| 6| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                             X            |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |             X                 X     X     X  X     X  X  X  X            |             
      Osteosarcoma, Metastatic, Bone       |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X        X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +           +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X        X        X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X     X              X  X     X     X  X  X  X  X  X  X            |             
      Mesothelioma NOS                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  40                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 6| 2| 3|                                                                 |            |
                                           | 5| 8| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0.0MG/M3                               | 6| 6| 7|                                                                 |     L      |
                                           | 7| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  51        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  51        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Adenoma               |                                                                          |          4 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |         24 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          6 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |          9 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  41                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 6| 2| 3|                                                                 |            |
                                           | 5| 8| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0.0MG/M3                               | 6| 6| 7|                                                                 |     L      |
                                           | 7| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          6 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |          9 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |         12 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          6 |
      Pars Distalis, Adenoma               | X  X                                                                     |         20 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          4 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Mediastinum, Leukemia Mononuclear    |                                                                          |          1 |
      Thoracic, Fibrosarcoma               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +     +                                                                  |  39        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Penis                                   |    +  +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  42                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 6| 2| 3|                                                                 |            |
                                           | 5| 8| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0.0MG/M3                               | 6| 6| 7|                                                                 |     L      |
                                           | 7| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Interstitial Cell, Adenoma|                                                                          |         28 |
      Interstitial Cell, Adenoma           |                                                                          |         11 |
      Tunic, Mesothelioma NOS              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   5        |
      Axillary, Leukemia Mononuclear       |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |       X                                                                  |          4 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |         28 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  49        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Preputial     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Fibroma                              |                                                                          |          2 |
      Keratoacanthoma                      |    X                                                                     |          4 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Pinna, Keratoacanthoma               |                                                                          |          1 |
      Pinna, Squamous Cell Papilloma       |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  43                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 6| 2| 3|                                                                 |            |
                                           | 5| 8| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0.0MG/M3                               | 6| 6| 7|                                                                 |     L      |
                                           | 7| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Tail, Fibroma                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Cranium, Osteosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Astrocytoma Benign                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Preputial     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |         23 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |       X                                                                  |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |         28 |
      Mesothelioma NOS                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  44                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9| 3|             
                                           | 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X  X        X     X  X  X     X  X     X  X  X           X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X                 X                 X  X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X        X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X     X  X  X     X        X                    X            |             
      Pheochromocytoma Malignant           | X                                                                        |             
      Pheochromocytoma Benign              | X     X  X     X        X     X  X              X        X  X     X  X  X|             
      Bilateral, Pheochromocytoma Benign   |                   X        X                                   X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                 X        X                                             |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X              X                           |             
      Pars Distalis, Adenoma               |                X                    X        X        X  X     X  X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                           X     X                        |             
      C-Cell, Carcinoma                    |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9| 3|             
                                           | 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                X         |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X     X  X           X     X     X  X  X                 X  X     X  X|             
      Interstitial Cell, Adenoma           |       X        X     X     X     X              X                 X      |             
      Tunic, Mesothelioma NOS              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X  X        X        X  X                 X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +     +     +        +  +  +                           |             
      Axillary, Leukemia Mononuclear       |                                        X  X  X                           |             
      Deep Cervical, Leukemia Mononuclear  |                                        X  X                              |             
      Iliac, Leukemia Mononuclear          |                   X                    X  X  X                           |             
      Pancreatic, Leukemia Mononuclear     |                   X     X     X        X  X                              |             
      Renal, Leukemia Mononuclear          | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                   X  X        X        X  X  X           X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X  X     X        X  X  X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X     X     X        X  X  X              X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                X         |             
      Leukemia Mononuclear                 |    X        X     X  X  X     X        X  X  X           X  X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X  X     X  X     X  X  X           X  X            |             
      Mesothelioma NOS, Metastatic         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |    X        X     X  X  X     X        X  X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  46                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9| 3|             
                                           | 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +|             
      Fibroadenoma                         |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Fibroma                              |                X                                                         |             
      Keratoacanthoma                      |                                                                          |             
      Tail, Squamous Cell Papilloma        | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Oligodendroglioma NOS                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                    X                                                   |             
      Alveolar/Bronchiolar Carcinoma       |                                                             X  X         |             
      Leukemia Mononuclear                 | X  X              X  X  X     X        X  X  X           X  X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                    +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X              X     X     X           X                              |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                       +                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X        X                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X  X     X  X     X  X  X           X  X            |             
      Mesothelioma NOS                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  47                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 6| 7| 7| 7| 6| 6| 4| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 9| 6| 3| 2| 3| 3| 3| 5| 3| 5| 0| 3| 3| 3| 3| 3| 4| 1| 6| 3| 3| 1| 3| 9|             
                                           | 9| 5| 9| 8| 4| 6| 6| 6| 0| 9| 5| 1| 3| 3| 6| 8| 7| 2| 3| 1| 6| 3| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/M3                                  | 0| 2| 3| 4| 7| 9| 0| 1| 4| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X  X     X  X        X  X  X              X     X  X  X  X     X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X           X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                            X                       X  X  X               |             
      Pheochromocytoma Malignant           |                                  X                                       |             
      Pheochromocytoma Benign              | X                 X           X  X     X  X     X        X     X         |             
      Bilateral, Pheochromocytoma Benign   |                X        X                                   X     X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Carcinoma                            |          X                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                    X                          X  X                  |             
      Pars Distalis, Adenoma               |    X                 X  X              X  X     X     X     X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  48                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 6| 7| 7| 7| 6| 6| 4| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 9| 6| 3| 2| 3| 3| 3| 5| 3| 5| 0| 3| 3| 3| 3| 3| 4| 1| 6| 3| 3| 1| 3| 9|             
                                           | 9| 5| 9| 8| 4| 6| 6| 6| 0| 9| 5| 1| 3| 3| 6| 8| 7| 2| 3| 1| 6| 3| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/M3                                  | 0| 2| 3| 4| 7| 9| 0| 1| 4| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X        X     X  X  X  X     X  X  X     X           X  X  X  X  X  X|             
      Interstitial Cell, Adenoma           |       X  X     X              X           X     X  X  X                  |             
      Tunic, Mesothelioma NOS              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X        X  X                          X  X        X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +              +  +  +           +        +           +     +|             
      Axillary, Leukemia Mononuclear       |                                                       X                  |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                         X|             
      Pancreatic, Leukemia Mononuclear     |    X        X              X                                      X     X|             
      Renal, Leukemia Mononuclear          |                            X                 X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X                 X     X  X  X        X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                       X  X           X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X                 X     X  X  X        X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |                            X              X  X     X  X  X        X     X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X  X     X  X  X  X           X  X     X  X  X  X  X  X     X|             
      Mesothelioma NOS, Metastatic         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                 X     X  X  X        X     X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 6| 7| 7| 7| 6| 6| 4| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 4| 9| 6| 3| 2| 3| 3| 3| 5| 3| 5| 0| 3| 3| 3| 3| 3| 4| 1| 6| 3| 3| 1| 3| 9|             
                                           | 9| 5| 9| 8| 4| 6| 6| 6| 0| 9| 5| 1| 3| 3| 6| 8| 7| 2| 3| 1| 6| 3| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/M3                                  | 0| 2| 3| 4| 7| 9| 0| 1| 4| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                             X            |             
      Fibroma                              | X                                                                        |             
      Keratoacanthoma                      |                X     X              X        X                           |             
      Tail, Squamous Cell Papilloma        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Oligodendroglioma NOS                |                                                                         X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                                                                        |             
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |             
      Leukemia Mononuclear                 |    X  X     X  X           X  X              X     X  X  X        X     X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +           +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                          X           X      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X  X     X  X  X  X           X  X     X  X  X  X  X  X     X|             
      Mesothelioma NOS                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 7| 3| 3|                                                                 |            |
                                           | 0| 3| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 0| 0| 1|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +                                                                  |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Adenoma               | X                                                                        |          1 |
      Leukemia Mononuclear                 |                                                                          |         27 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |         13 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |       X                                                                  |         23 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          4 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +                                                                  |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  51                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 7| 3| 3|                                                                 |            |
                                           | 0| 3| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 0| 0| 1|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               | X     X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Thoracic, Alveolar/Bronchiolar       |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +                                                                  |  47        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  53        |
      Bilateral, Interstitial Cell, Adenoma|    X                                                                     |         30 |
      Interstitial Cell, Adenoma           |                                                                          |         15 |
      Tunic, Mesothelioma NOS              |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  M  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  16        |
      Axillary, Leukemia Mononuclear       |                                                                          |          4 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          5 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |         10 |
      Renal, Leukemia Mononuclear          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         16 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  52                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 7| 3| 3|                                                                 |            |
                                           | 0| 3| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 0| 0| 1|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +                                                                  |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         19 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         32 |
      Mesothelioma NOS, Metastatic         |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
      Leukemia Mononuclear                 |                                                                          |         15 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M                                                                  |  48        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Fibroma                              |                                                                          |          2 |
      Keratoacanthoma                      |                                                                          |          4 |
      Tail, Squamous Cell Papilloma        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  M  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Oligodendroglioma NOS                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |         23 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  53                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 7| 3| 3|                                                                 |            |
                                           | 0| 3| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.15                                   | 0| 0| 1|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         32 |
      Mesothelioma NOS                     |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  54                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 9| 4| 4| 1| 9| 5| 3| 3| 0| 2| 7| 0| 3| 5| 2| 3| 6| 2| 3| 3| 3| 0| 3| 2| 3|             
                                           | 0| 3| 8| 1| 4| 2| 6| 3| 3| 3| 8| 3| 6| 9| 7| 6| 3| 3| 3| 3| 3| 9| 3| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    MG/M3                                  | 2| 3| 4| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Testes     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                      X  X                             X                  |             
      Leukemia Mononuclear                 | X  X  X     X  X     X  X  X  X  X           X  X  X  X        X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |          +                                                               |             
      Squamous Cell Papilloma              |          X                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Squamous Cell Carcinoma     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X  X        X                    X  X              X  X  X   |             
      Pheochromocytoma Malignant           |          X                 X     X           X                           |             
      Pheochromocytoma Benign              | X        X     X           X     X           X                          X|             
      Bilateral, Pheochromocytoma Malignant|                   X                 X                 X     X            |             
      Bilateral, Pheochromocytoma Benign   |    X  X     X        X  X     X                 X        X        X  X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X     X                                 |             
      Carcinoma                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X                                         X      |             
      Pars Distalis, Adenoma               |             X     X              X     X  X                 X  X     X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  55                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 9| 4| 4| 1| 9| 5| 3| 3| 0| 2| 7| 0| 3| 5| 2| 3| 6| 2| 3| 3| 3| 0| 3| 2| 3|             
                                           | 0| 3| 8| 1| 4| 2| 6| 3| 3| 3| 8| 3| 6| 9| 7| 6| 3| 3| 3| 3| 3| 9| 3| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    MG/M3                                  | 2| 3| 4| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                            X     X                          X           X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Fibrosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                 +                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|          X        X           X              X  X           X            |             
      Interstitial Cell, Adenoma           | X  X        X  X        X  X     X  X     X        X     X           X  X|             
      Tunic, Fibrosarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X              X     X        X        X  X  X  X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +     +                          +                        |             
      Axillary, Leukemia Mononuclear       |                                                 X                        |             
      Iliac, Fibrosarcoma, Metastatic,     |                                                                          |             
           Testes                          |                                                                          |             
      Iliac, Leukemia Mononuclear          |                      X                          X                        |             
      Pancreatic, Leukemia Mononuclear     |                X     X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X     X        X              X  X  X                 X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X     X                 X  X              X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X     X  X           X           X  X           X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Leukemia Mononuclear                 |       X        X     X     X  X     X        X  X  X                 X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X     X  X  X  X  X  X     X  X  X  X  X        X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X                          X  X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  56                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 9| 4| 4| 1| 9| 5| 3| 3| 0| 2| 7| 0| 3| 5| 2| 3| 6| 2| 3| 3| 3| 0| 3| 2| 3|             
                                           | 0| 3| 8| 1| 4| 2| 6| 3| 3| 3| 8| 3| 6| 9| 7| 6| 3| 3| 3| 3| 3| 9| 3| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    MG/M3                                  | 2| 3| 4| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  I  +  +  M  +  +  +  +  +  +  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Fibroma                              |                                           X           X                  |             
      Keratoacanthoma                      |                                                             X            |             
      Nose, Squamous Cell Papilloma        |                      X                                                   |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Osteosarcoma                |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                      X   |             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                              X           X               |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |       X                                      X                    X      |             
      Chordoma, Metastatic, Tissue NOS     |                                  X                                       |             
      Fibrosarcoma, Metastatic, Testes     |                                                                          |             
      Leukemia Mononuclear                 | X  X           X     X     X  X     X           X  X  X        X     X   |             
      Osteosarcoma, Metastatic, Bone       |                                                    X                     |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X     X  X  X  X  X  X     X  X  X  X  X        X  X  X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  57                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 3| 3| 5| 7| 2| 4| 6| 3| 3| 1| 0| 3| 3| 3| 9| 6| 3| 6| 3| 2| 3| 0|             
                                           | 4| 1| 8| 6| 3| 0| 7| 1| 2| 3| 7| 3| 6| 7| 7| 6| 7| 5| 4| 6| 0| 1| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MG/M3                                  | 4| 5| 6| 7| 8| 0| 1| 3| 5| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Testes     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X  X  X                 X  X  X     X     X     X     X  X        X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Gingiva, Squamous Cell Carcinoma     |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                           |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X        X     X           X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                 X  X  X     X                 X  X               |             
      Pheochromocytoma Malignant           |                               X        X                                 |             
      Pheochromocytoma Benign              |          X     X     X  X     X        X           X                     |             
      Bilateral, Pheochromocytoma Malignant|                                                                      X   |             
      Bilateral, Pheochromocytoma Benign   |    X        X              X     X  X     X  X  X        X  X  X  X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X        X                                          |             
      Carcinoma                            |                X                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Pars Distalis, Adenoma               |                   X  X                 X     X     X              X  X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  58                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 3| 3| 5| 7| 2| 4| 6| 3| 3| 1| 0| 3| 3| 3| 9| 6| 3| 6| 3| 2| 3| 0|             
                                           | 4| 1| 8| 6| 3| 0| 7| 1| 2| 3| 7| 3| 6| 7| 7| 6| 7| 5| 4| 6| 0| 1| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MG/M3                                  | 4| 5| 6| 7| 8| 0| 1| 3| 5| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X           X     X        X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Abdominal, Fibrosarcoma              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X     X                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X     X|             
      Bilateral, Interstitial Cell, Adenoma|       X        X              X     X     X     X        X     X         |             
      Interstitial Cell, Adenoma           |          X  X                    X     X     X              X        X   |             
      Tunic, Fibrosarcoma                  |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X           X     X     X                 X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                          +                          +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Fibrosarcoma, Metastatic,     |                                                                          |             
           Testes                          |                   X                                                      |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                       X     X     X     X                       X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                 X           X           X                       X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                       X                          X              X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |    X  X                       X     X     X     X                       X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                 X  X  X  X  X     X  X  X     X  X  X     X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                       X           X     X                       X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  59                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 3| 3| 5| 7| 2| 4| 6| 3| 3| 1| 0| 3| 3| 3| 9| 6| 3| 6| 3| 2| 3| 0|             
                                           | 4| 1| 8| 6| 3| 0| 7| 1| 2| 3| 7| 3| 6| 7| 7| 6| 7| 5| 4| 6| 0| 1| 6| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MG/M3                                  | 4| 5| 6| 7| 8| 0| 1| 3| 5| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                         X                                                |             
      Fibroma                              |                               X                                          |             
      Keratoacanthoma                      |                                                                          |             
      Nose, Squamous Cell Papilloma        |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Osteosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
      Leukemia Mononuclear                 |       X                                               X  X               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                                               X     X         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                  X                                       |             
      Alveolar/Bronchiolar Carcinoma       |    X     X  X                                                     X      |             
      Chordoma, Metastatic, Tissue NOS     |                                                                          |             
      Fibrosarcoma, Metastatic, Testes     |                   X                                                      |             
      Leukemia Mononuclear                 |    X  X                 X  X  X     X     X     X     X  X              X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                         X     X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                       X           X     X     X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                 X  X  X  X  X     X  X  X     X  X  X     X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  60                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 8| 0| 6|                                                                 |            |
                                           | 4| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.0                                    | 4| 4| 5|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M                                                                  |  52        |
      Fibrosarcoma, Metastatic, Testes     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |         30 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Gingiva, Squamous Cell Carcinoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         18 |
      Pheochromocytoma Malignant           |                                                                          |          6 |
      Pheochromocytoma Benign              |                                                                          |         14 |
      Bilateral, Pheochromocytoma Malignant|                                                                          |          5 |
      Bilateral, Pheochromocytoma Benign   |    X                                                                     |         23 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  61                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 8| 0| 6|                                                                 |            |
                                           | 4| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.0                                    | 4| 4| 5|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pars Distalis, Adenoma               | X     X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |       X                                                                  |          9 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Abdominal, Fibrosarcoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +                                                                  |  48        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma|    X                                                                     |         15 |
      Interstitial Cell, Adenoma           |                                                                          |         20 |
      Tunic, Fibrosarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         16 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Iliac, Fibrosarcoma, Metastatic,     |                                                                          |            |
           Testes                          |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |         12 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  62                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 8| 0| 6|                                                                 |            |
                                           | 4| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.0                                    | 4| 4| 5|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |         17 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         35 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M                                                                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          9 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  43        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Fibroma                              |                                                                          |          3 |
      Keratoacanthoma                      |                                                                          |          1 |
      Nose, Squamous Cell Papilloma        |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Maxilla, Osteosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Astrocytoma NOS                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          7 |
      Chordoma, Metastatic, Tissue NOS     |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Testes     |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         23 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  63                                                               
NTP Experiment-Test: 05107-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:46:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5|                                                                 |            |
                             DAY ON TEST   | 8| 0| 6|                                                                 |            |
                                           | 4| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.0                                    | 4| 4| 5|                                                                 |     L      |
    MG/M3                                  | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Adrenal Medulla      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         35 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  64                                                               
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                                  ----------              END OF REPORT             ----------                                      
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