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TDMS Study 05107-06 Pathology Tables

NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04

                                                          Core Animals




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant                   |                                        X                                X|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |          X     X     X                    X  X           X     X     X   |             
      Hepatocellular Adenoma               |                                           X                    X         |             
      Hepatocellular Adenoma, Multiple     |                      X                 X                                 |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |       X     X           X                          X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                      X                                                   |             
      Follicular Cell, Carcinoma           |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                  X                                       |             
      Histiocytic Sarcoma                  |                                              X              X            |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                             +  +           +|             
      Axillary, Lymphoma Malignant         |                                                                         X|             
      Iliac, Hemangiosarcoma               |                                                          X               |             
      Iliac, Lymphoma Malignant            |                                                                         X|             
      Inguinal, Lymphoma Malignant         |                                                                         X|             
      Pancreatic, Lymphoma Malignant       |                                                                         X|             
      Renal, Histiocytic Sarcoma,          |                                                                          |             
          Metastatic, Uterus               |                                                             X            |             
      Renal, Lymphoma Malignant            |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                        X                                X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  +  M  +  M  M  M  M  I  M  M  +  M  M  +  +  I  +  +  M  M  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                        X                                X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenocarcinoma                       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pinna, Fibrosarcoma                  | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                   X                                                      |             
      Alveolar/Bronchiolar Adenoma         |                                                       X        X         |             
      Alveolar/Bronchiolar Carcinoma       |                                           X        X           X         |             
      Hepatocellular Carcinoma, Metastatic |                                           X                              |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                X     X                                                   |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8| 3| 9| 7|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 4| 3| 6| 9| 3| 4| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                      +   |             
      Adenoma                              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                   X                                                      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                X         |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X              X            |             
      Lymphoma Malignant                   |                                        X                                X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|             
                                           | 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  M  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|             
      Polyp Adenomatous                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                           X  X                           |             
      Hepatocellular Carcinoma             |          X     X     X                                                   |             
      Hepatocellular Adenoma               |                            X  X              X        X        X         |             
      Hepatocellular Adenoma, Multiple     | X        X                                                               |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Liver   |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|             
                                           | 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |       X                          X  X                             X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |    X                                                                     |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |          X  X                                                            |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                    +     +                                       |             
      Axillary, Lymphoma Malignant         |                                                                          |             
      Iliac, Hemangiosarcoma               |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                  X                                       |             
      Renal, Histiocytic Sarcoma,          |                                                                          |             
          Metastatic, Uterus               |                                                                          |             
      Renal, Lymphoma Malignant            |       X                          X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  I  I  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |       X                          X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|             
                                           | 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  M  M  M  M  M  M  +  M  M  M  +  +  M  M  M  +  +  M  M  +  M  M  M  M|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                           X                              |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pinna, Fibrosarcoma                  |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |       X                                         X                        |             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   8                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3| 6|             
                                           | 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Uterus                          |                                                                          |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |       X                          X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 7| 7|                                                  |            |
                             DAY ON TEST   | 3| 3| 0| 3| 8| 3| 3| 3|                                                  |            |
                                           | 3| 3| 0| 3| 5| 6| 5| 5|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |     A      |
    0.0MG/M3                               | 5| 5| 5| 5| 5| 5| 5| 6|                                                  |     L      |
                                           | 1| 2| 3| 4| 5| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  I  +  +  +  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  M  +  M  +  +  M  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  54        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +                                                   |  53        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +                                                   |  54        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Hepatocellular Carcinoma             |                                                                          |         11 |
      Hepatocellular Adenoma               |    X     X                                                               |          9 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          4 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   3        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  58        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  58        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 7| 7|                                                  |            |
                             DAY ON TEST   | 3| 3| 0| 3| 8| 3| 3| 3|                                                  |            |
                                           | 3| 3| 0| 3| 5| 6| 5| 5|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |     A      |
    0.0MG/M3                               | 5| 5| 5| 5| 5| 5| 5| 6|                                                  |     L      |
                                           | 1| 2| 3| 4| 5| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +                                                   |  58        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M                                                   |  52        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Pars Distalis, Adenoma               |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +                                                   |  58        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +                                                   |  55        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Cystadenoma                          |                                                                          |          2 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Polyp Stromal                        |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  57        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +        +                                                   |   9        |
      Axillary, Lymphoma Malignant         |                                                                          |          1 |
      Iliac, Hemangiosarcoma               |                                                                          |          1 |
      Iliac, Lymphoma Malignant            |                      X                                                   |          2 |
      Inguinal, Lymphoma Malignant         |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          2 |
      Renal, Histiocytic Sarcoma,          |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                      X                                                   |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 7| 7|                                                  |            |
                             DAY ON TEST   | 3| 3| 0| 3| 8| 3| 3| 3|                                                  |            |
                                           | 3| 3| 0| 3| 5| 6| 5| 5|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |     A      |
    0.0MG/M3                               | 5| 5| 5| 5| 5| 5| 5| 6|                                                  |     L      |
                                           | 1| 2| 3| 4| 5| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  I  +  +  +  +  +                                                   |  50        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +                                                   |  55        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  M  M  M                                                   |  15        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Fibrosarcoma                         |                                                                          |          1 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Lymphoma Malignant                   |                      X                                                   |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +                                                   |  57        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Pinna, Fibrosarcoma                  |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 7| 7|                                                  |            |
                             DAY ON TEST   | 3| 3| 0| 3| 8| 3| 3| 3|                                                  |            |
                                           | 3| 3| 0| 3| 5| 6| 5| 5|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1|                                                  |     A      |
    0.0MG/M3                               | 5| 5| 5| 5| 5| 5| 5| 6|                                                  |     L      |
                                           | 1| 2| 3| 4| 5| 8| 9| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  M                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          3 |
      Alveolar/Bronchiolar Carcinoma       | X                 X                                                      |          7 |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Uterus                          |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +                                                   |  56        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant                   |                      X                                                   |          5 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant                   |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant                   |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  M  M  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |       X                 X        X     X     X                           |             
      Hepatocellular Carcinoma, Multiple   |                                           X                              |             
      Hepatocellular Adenoma               |                                  X                             X  X      |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
      Histiocytic Sarcoma                  |          X                                                               |             
      Lymphoma Malignant                   |                X                                                  X      |             
      Sarcoma, Metastatic, Skeletal Muscle |                      X                                                   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +        +                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                      X                                                   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                X                                                  X      |             
      Sarcoma, Metastatic, Skeletal Muscle |                      X                                                   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                               X                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
      Lymphoma Malignant                   |                X                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
      Sarcoma, Metastatic, Skeletal Muscle |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                      X                                                   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                       X           X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |    X                                                                    X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +     +                       +                                 |             
      Histiocytic Sarcoma                  |          X                                                               |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                        X                                 |             
      Mediastinum, Hemangiosarcoma         |                                                                          |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |                                                          X               |             
      Lymphoma Malignant                   |                X                                                         |             
      Sarcoma, Metastatic, Skeletal Muscle |                      X                                                   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
      Teratoma Benign                      |                                                                          |             
      Teratoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |             
          NOS                              |                                                                          |             
      Lymphoma Malignant                   |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +              +                                   +      |             
      Axillary, Lymphoma Malignant         |                X                                                         |             
      Iliac, Lymphoma Malignant            |                X                                                  X      |             
      Inguinal, Lymphoma Malignant         |                X                                                         |             
      Lumbar, Lymphoma Malignant           |                X                                                         |             
      Pancreatic, Histiocytic Sarcoma      |          X                                                               |             
      Pancreatic, Lymphoma Malignant       |                X                                                         |             
      Pancreatic, Squamous Cell Carcinoma, |                                                                          |             
           Metastatic, Stomach, Forestomach|                               X                                          |             
      Popliteal, Lymphoma Malignant        |                X                                                         |             
      Renal, Lymphoma Malignant            |                X                                                  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
      Histiocytic Sarcoma                  |          X                                                               |             
      Lymphoma Malignant                   |                X                                                  X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                X                          X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Lymphoma Malignant                   |                X                                                  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  M  +  +  M  +  I  +  M  M  M  +  M  +  M  I  +  +  +  +  I  +|             
      Lymphoma Malignant                   |                X                                                  X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |             
          NOS                              |                                                                          |             
      Histiocytic Sarcoma                  |          X                                                               |             
      Lymphoma Malignant                   |                X                                                  X      |             
      Teratoma Malignant, Metastatic, Ovary|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
      Histiocytic Sarcoma                  |          X                                                               |             
      Lymphoma Malignant                   |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |       X                                                                 X|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                   +               |             
      Hemangiosarcoma                      |                                                          X               |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Sarcoma                              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Epithelium, Squamous Cell Carcinoma  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                  X     X  X  X                           |             
      Histiocytic Sarcoma                  |          X                                                               |             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Metastatic                       |                                                                   X      |             
      Lymphoma Malignant                   |                X                                                         |             
      Sarcoma, Metastatic, Skeletal Muscle |                      X                                                   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                X                                                  X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                               X                                          |             
      Teratoma Malignant, Metastatic, Ovary|                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                X                                                  X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X                                                               |             
      Lymphoma Malignant                   |                X                          X                       X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      | X                                                                        |             
      Hepatocellular Carcinoma             |                            X  X                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               | X     X  X                                                     X  X      |             
      Hepatocellular Adenoma, Multiple     |                                     X                                    |             
      Histiocytic Sarcoma                  |    X                                                                     |             
      Lymphoma Malignant                   |                X                 X                 X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Lymphoma Malignant                   |                                                    X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant                   |                X                 X                 X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Lymphoma Malignant                   |                                  X                 X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Adenoma                              |                                                       X                  |             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  I|             
      Pars Distalis, Adenoma               |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                 X                 X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Hemangiosarcoma         |                                                                          |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant                   |                   X              X                 X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
      Teratoma Benign                      |                                                                         X|             
      Teratoma Malignant                   |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |    X                                                                     |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |             
          NOS                              |                                                                          |             
      Lymphoma Malignant                   |                                  X                 X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +              +     +           +              +      |             
      Axillary, Lymphoma Malignant         |                   X              X                 X                     |             
      Iliac, Lymphoma Malignant            |                   X              X                 X                     |             
      Inguinal, Lymphoma Malignant         |                                  X                 X                     |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                X  X              X                 X                     |             
      Pancreatic, Squamous Cell Carcinoma, |                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Popliteal, Lymphoma Malignant        |                                                                          |             
      Renal, Lymphoma Malignant            |                X  X              X                 X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                   X              X                 X                     |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                   X              X                 X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                       X                  |             
      Lymphoma Malignant                   |                X  X              X                 X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  M  +  +  +  M  M  +  M  +  +  I  M  M  M  +  +  I  M  M  M  +  M|             
      Lymphoma Malignant                   |                X  X              X                 X                     |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                       X                  |             
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |             
          NOS                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                X  X              X                 X                     |             
      Teratoma Malignant, Metastatic, Ovary|                                                             X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                  X                 X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |       X                                                                  |             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                       X                  |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
      Epithelium, Squamous Cell Carcinoma  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                            X                                             |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Metastatic                       |                                                                          |             
      Lymphoma Malignant                   |                                  X                 X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                X  X              X                 X                     |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
      Teratoma Malignant, Metastatic, Ovary|                                                             X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |    X                                                                     |             
      Lymphoma Malignant                   |                X  X              X                 X                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  23                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  A  +  +                                             |  51        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +                                             |  55        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  A  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  A  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |    X                                                                     |          8 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          8 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          5 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  M  +  +  +  A  +  +                                             |  56        |
      Lymphoma Malignant                   |                                                                          |          5 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +                                             |  58        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  24                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Lymphoma Malignant                   |                                                                          |          2 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  M  +  +  +  A  +  +                                             |  56        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Pars Distalis, Adenoma               |          X        X                                                      |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Adenoma             |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   4        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinum, Hemangiosarcoma         |       X                                                                  |          1 |
      Thoracic, Alveolar/Bronchiolar       |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  A  +  +                                             |  58        |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  25                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
      Teratoma Benign                      |                                                                          |          1 |
      Teratoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Polyp Stromal                        |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |            |
          NOS                              |       X                                                                  |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |  12        |
      Axillary, Lymphoma Malignant         |                                                                          |          4 |
      Iliac, Lymphoma Malignant            |                                                                          |          5 |
      Inguinal, Lymphoma Malignant         |                                                                          |          3 |
      Lumbar, Lymphoma Malignant           |                                                                          |          1 |
      Pancreatic, Histiocytic Sarcoma      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          5 |
      Pancreatic, Squamous Cell Carcinoma, |                                                                          |            |
           Metastatic, Stomach, Forestomach|                                                                          |          1 |
      Popliteal, Lymphoma Malignant        |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +                                             |  57        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          5 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lymphoma Malignant                   |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  A  +  +                                             |  54        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  +  +  +  M  I  +                                             |  28        |
      Lymphoma Malignant                   |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  26                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |            |
          NOS                              |       X                                                                  |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          6 |
      Teratoma Malignant, Metastatic, Ovary|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  A  +  +                                             |  57        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +                                             |  59        |
      Adenocarcinoma                       |                                                                          |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Keratoacanthoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  I  +  +  +  +  +                                             |  55        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Epithelium, Squamous Cell Carcinoma  |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  27                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X                                                                     |          6 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic,      |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  A  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          6 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
      Teratoma Malignant, Metastatic, Ovary|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +                                             |  55        |
      Lymphoma Malignant                   |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          7 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  28                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  M  A  +  +  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  A  +  A  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  A  +  A  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  A  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X                 X                                            X         |             
      Hepatocellular Adenoma               |       X                 X           X                             X      |             
      Hepatocellular Adenoma, Multiple     |    X                                                                     |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant                   |       X                             X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Histiocytic Sarcoma                  |                                                          X               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Buccal, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
      Sarcoma, Metastatic, Skeletal Muscle |                            X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                      X                                                  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  A  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Polyp Stromal                        |                                                                          |             
      Endometrium, Adenocarcinoma          |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                    +  +     +                                   +|             
      Iliac, Lymphoma Malignant            |       X                             X                                    |             
      Iliac, Sarcoma, Metastatic, Skeletal |                                                                          |             
          Muscle                           |                            X                                             |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Pancreatic, Sarcoma, Metastatic,     |                                                                          |             
           Skeletal Muscle                 |                            X                                             |             
      Renal, Lymphoma Malignant            |       X                             X                                    |             
      Renal, Sarcoma, Metastatic, Skeletal |                                                                          |             
          Muscle                           |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |       X                             X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |       X                             X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |       X                             X                                    |             
      Sarcoma, Metastatic, Skeletal Muscle |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  +  I  M  M  +  +  M  +  +  +  +  M  +  M  +  I  M  +  M  M  M  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                  X                                       |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant                   |       X                             X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
      Pinna, Fibrosarcoma                  |                                                                          |             
      Pinna, Squamous Cell Carcinoma       |                               X                                          |             
      Sebaceous Gland, Squamous Cell       |                                                                          |             
          Carcinoma                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                             X            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Sarcoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
      Lymphoma Malignant                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                     +                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant                   |       X                             X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant                   |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                           X                              |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |    X                                               X                 X   |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                               X              X                 X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Buccal, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                      X                                      X        X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                           X                              |             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        | X                                                                        |             
      Endometrium, Adenocarcinoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  +  +                                +         |             
      Iliac, Lymphoma Malignant            |                               X                                          |             
      Iliac, Sarcoma, Metastatic, Skeletal |                                                                          |             
          Muscle                           |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                         X     X                                X         |             
      Pancreatic, Sarcoma, Metastatic,     |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
      Renal, Lymphoma Malignant            |                               X                                          |             
      Renal, Sarcoma, Metastatic, Skeletal |                                                                          |             
          Muscle                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                               X                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                               X                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  M  M  I  +  +  M  I  +  +  +  +  M  M  M  M  +  M  +  M  +  M  +  M  +|             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                         X     X                                X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant                   |                               X              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                                          X               |             
      Lymphoma Malignant                   |                                                                          |             
      Pinna, Fibrosarcoma                  |                                                                          |             
      Pinna, Squamous Cell Carcinoma       |                                                                          |             
      Sebaceous Gland, Squamous Cell       |                                                                          |             
          Carcinoma                        |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                      X   |             
      Alveolar/Bronchiolar Carcinoma       |          X                 X                                             |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                               X                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                             X            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                               +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                         X     X              X                 X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 5|                                                  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 8|                                                  |            |
                                           | 3| 5| 3| 3| 2| 5| 3| 0|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |     A      |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7|                                                  |     L      |
                                           | 6| 8| 0| 1| 3| 5| 8| 9|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +                                                   |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +                                                   |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  M  +  +                                                   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +                                                   |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +                                                   |  51        |
      Adenoma                              |             X                                                            |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +                                                   |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |       X                                                                  |          4 |
      Hepatocellular Adenoma               |       X     X                                                            |          9 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |   1        |
      Buccal, Squamous Cell Papilloma      |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |  57        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  56        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  58        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Pheochromocytoma Benign              |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  37                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 5|                                                  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 8|                                                  |            |
                                           | 3| 5| 3| 3| 2| 5| 3| 0|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |     A      |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7|                                                  |     L      |
                                           | 6| 8| 0| 1| 3| 5| 8| 9|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Pars Distalis, Adenoma               |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +                                                   |  58        |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +                                                   |  51        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Cystadenoma                          |                      X                                                   |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Fibroma                              |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
      Endometrium, Adenocarcinoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  57        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +                                                      |  11        |
      Iliac, Lymphoma Malignant            |                                                                          |          3 |
      Iliac, Sarcoma, Metastatic, Skeletal |                                                                          |            |
          Muscle                           |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          3 |
      Pancreatic, Sarcoma, Metastatic,     |                                                                          |            |
           Skeletal Muscle                 |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |          3 |
      Renal, Sarcoma, Metastatic, Skeletal |                                                                          |            |
          Muscle                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +                                                   |  58        |
      Lymphoma Malignant                   |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +                                                   |  58        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  38                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 5|                                                  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 8|                                                  |            |
                                           | 3| 5| 3| 3| 2| 5| 3| 0|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |     A      |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7|                                                  |     L      |
                                           | 6| 8| 0| 1| 3| 5| 8| 9|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +                                                   |  55        |
      Lymphoma Malignant                   |                                                                          |          3 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  M                                                   |  29        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +                                                   |  53        |
      Lymphoma Malignant                   |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Fibroma                              |             X                                                            |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Pinna, Fibrosarcoma                  |                      X                                                   |          1 |
      Pinna, Squamous Cell Carcinoma       |                                                                          |          1 |
      Sebaceous Gland, Squamous Cell       |                                                                          |            |
          Carcinoma                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  I  +  +  +  +  I  +                                                   |  51        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  39                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 5|                                                  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 8|                                                  |            |
                                           | 3| 5| 3| 3| 2| 5| 3| 0|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |     A      |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7|                                                  |     L      |
                                           | 6| 8| 0| 1| 3| 5| 8| 9|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  58        |
      Hemangioma                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +                                                   |  56        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   1        |
      Adenoma                              |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  58        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +                                                   |  57        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +                                                   |  58        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  40                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4|                                                                    |            |
                             DAY ON TEST   | 7| 4|                                                                    |            |
                                           | 4| 5|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 4| 4|                                                                    |     A      |
    1.2MG/M3                               | 2| 7|                                                                    |     L      |
    LUNG TOX                               | 6| 4|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |   2        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | I  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  41                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4|                                                                    |            |
                             DAY ON TEST   | 7| 4|                                                                    |            |
                                           | 4| 5|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 4| 4|                                                                    |     A      |
    1.2MG/M3                               | 2| 7|                                                                    |     L      |
    LUNG TOX                               | 6| 4|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |   2        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |   2        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +                                                                     |   2        |
      Histiocytic Sarcoma                  |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  42                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|             
                                           | 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Hepatocellular Carcinoma             |             X                       X                       X            |             
      Hepatocellular Adenoma               |                                  X        X           X        X         |             
      Hepatocellular Adenoma, Multiple     |                                              X                           |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
      Capsule, Adenoma                     |                X                                                     X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|             
                                           | 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Complex             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +  +     +        +        +                          +        +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +                 +              +  +        +           +   |             
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                 X                        |             
      Pancreatic, Fibrous Histiocytoma,    |                                                                          |             
           Metastatic, Liver               |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  M  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hemangioma                           |                         X                                                |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|             
                                           | 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  M  M  M  +  +  M  M  +  M  +  M  M  +  M  M  M  M  +  M  M  M  M|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X           X      |             
      Alveolar/Bronchiolar Adenoma, Two    |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                         X  X              X                              |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Pheochromocytoma Complex, Metastatic,|                                                                          |             
           Adrenal Medulla                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3| 3|             
                                           | 0| 4| 6| 4| 1| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pelvis, Hemangiosarcoma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                         +                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  46                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|             
                                           | 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  M  +  M  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |          X                                                               |             
      Hepatocellular Carcinoma             | X        X                             X           X                     |             
      Hepatocellular Adenoma               |       X     X  X                    X                    X  X            |             
      Hepatocellular Adenoma, Multiple     |                                                                   X      |             
      Hepatocholangiocarcinoma             |       X                                                                  |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +     +              +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
      Capsule, Adenoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  47                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|             
                                           | 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Complex             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                              X     X                    X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |    X                                                                     |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   | +           +        +           +                                      +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +        +  +  +  +                    +     +              +|             
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
      Pancreatic, Fibrous Histiocytoma,    |                                                                          |             
           Metastatic, Liver               |          X                                                               |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +     +  I  M  +  M  +  +  +  M  M  +  +  M  I  I  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  48                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|             
                                           | 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  M  M  +  M  M  +  M  M  M  M  M  M  I  +  M  M  M  M  M  M  M  M  M  M|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  M  +  M  M  M  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |             
      Alveolar/Bronchiolar Adenoma, Two    |                   X                                                      |             
      Alveolar/Bronchiolar Carcinoma       |    X                                   X        X     X                  |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                                                        |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
      Pheochromocytoma Complex, Metastatic,|                                                                          |             
           Adrenal Medulla                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Adenoma                              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Liver                           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4| 1|             
                                           | 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pelvis, Hemangiosarcoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                         +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                      +                             +           +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 5| 7| 7| 6|                                               |            |
                             DAY ON TEST   | 4| 3| 6| 3| 8| 8| 4| 4| 3|                                               |            |
                                           | 0| 7| 3| 7| 8| 5| 1| 1| 1|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |     L      |
                                           | 0| 1| 3| 4| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +                                                |  56        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  M  +                                                |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  56        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +                                                |  55        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Hepatocellular Carcinoma             | X     X           X                                                      |         10 |
      Hepatocellular Adenoma               |                X                                                         |         11 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  51                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 5| 7| 7| 6|                                               |            |
                             DAY ON TEST   | 4| 3| 6| 3| 8| 8| 4| 4| 3|                                               |            |
                                           | 0| 7| 3| 7| 8| 5| 1| 1| 1|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |     L      |
                                           | 0| 1| 3| 4| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |                                                                          |          1 |
      Capsule, Adenoma                     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +                                                |  58        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
      Pheochromocytoma Complex             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  59        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +                                                |  54        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +                                                |  56        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  59        |
      Follicular Cell, Adenoma             |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Thoracic, Alveolar/Bronchiolar       |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |  18        |
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Pancreatic, Fibrous Histiocytoma,    |                                                                          |            |
           Metastatic, Liver               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  52                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 5| 7| 7| 6|                                               |            |
                             DAY ON TEST   | 4| 3| 6| 3| 8| 8| 4| 4| 3|                                               |            |
                                           | 0| 7| 3| 7| 8| 5| 1| 1| 1|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |     L      |
                                           | 0| 1| 3| 4| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Lymphoma Malignant       |                   X                                                      |          1 |
      Renal, Lymphoma Malignant            |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  I  +  M  +                                                |  39        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  M  +  M  +  M                                                |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +                                                |  56        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  M  +  +  M                                                |  12        |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Lymphoma Malignant                   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M                                                |  46        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M                                                |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  M  +  +                                                |  57        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Alveolar/Bronchiolar Adenoma         | X        X                                                               |          5 |
      Alveolar/Bronchiolar Adenoma, Two    |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          7 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X                                                                        |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  53                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 5| 7| 7| 6|                                               |            |
                             DAY ON TEST   | 4| 3| 6| 3| 8| 8| 4| 4| 3|                                               |            |
                                           | 0| 7| 3| 7| 8| 5| 1| 1| 1|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |     L      |
                                           | 0| 1| 3| 4| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Pheochromocytoma Complex, Metastatic,|                                                                          |            |
           Adrenal Medulla                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Liver                           |                                                                          |          1 |
      Pelvis, Hemangiosarcoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Leiomyosarcoma                       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Lymphoma Malignant                   |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  54                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4|                                                                    |            |
                             DAY ON TEST   | 6| 3|                                                                    |            |
                                           | 7| 4|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 0| 0|                                                                    |     A      |
    0.0MG/M3                               | 4| 6|                                                                    |     L      |
    LUNG TOX                               | 2| 6|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  A                                                                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  A                                                                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A                                                                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A                                                                     |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |   2        |
      Hepatocellular Carcinoma             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +                                                                     |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  55                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4|                                                                    |            |
                             DAY ON TEST   | 6| 3|                                                                    |            |
                                           | 7| 4|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 0| 0|                                                                    |     A      |
    0.0MG/M3                               | 4| 6|                                                                    |     L      |
    LUNG TOX                               | 2| 6|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M                                                                     |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M                                                                     |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | I  +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  56                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5| 2|             
                             DAY ON TEST   | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7| 4|             
                                           | 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.6MG/M3                               | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  M  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  A  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  M  +  +  +  +  +  +  +  A  M  M  A  +  +  +  +  +  M  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemangioma                           |                                                       X                  |             
      Hepatocellular Carcinoma             |       X        X  X                 X                    X  X            |             
      Hepatocellular Carcinoma, Multiple   |                               X                                          |             
      Hepatocellular Adenoma               |                                                                X         |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Follicular Cell, Adenoma             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   | +     +                                                  +     +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  57                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5| 2|             
                             DAY ON TEST   | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7| 4|             
                                           | 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.6MG/M3                               | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +                                         +        +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  +  M  +  +  +  I  A|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  +  M  I  I  I  I  M  M  M  I  +  M  +  M  M  M  I  M  I  M  A|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  A|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  A|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Prepuce, Fibrous Histiocytoma        |                                                                          |             
      Tail, Hemangiosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Alveolar/Bronchiolar Adenoma         |                   X                             X                        |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X        X                    X                                    |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  58                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5| 2|             
                             DAY ON TEST   | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7| 4|             
                                           | 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.6MG/M3                               | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +                       +           +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  59                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8| 9| 3|             
                                           | 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  M  +  M  M  +  M  M  +  +  +  M  M  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             | X  X                                      X     X        X  X  X  X      |             
      Hepatocellular Carcinoma, Multiple   |                               X                                          |             
      Hepatocellular Adenoma               |                                  X              X           X     X  X   |             
      Hepatocellular Adenoma, Multiple     |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   | +                 +                             +                    +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  60                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8| 9| 3|             
                                           | 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +                                         +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  I  I  +  I  M  M  +  +  M  M  +  I  +  +  +  +  +  M  M  I  M  +  M|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hemangiosarcoma                      |          X                                                               |             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Fibrous Histiocytoma        |                                     X                                    |             
      Tail, Hemangiosarcoma                |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |    X                                                     X     X         |             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  61                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8| 9| 3|             
                                           | 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                +                    +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  62                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 1| 7|                                                  |            |
                             DAY ON TEST   | 4| 4| 3| 4| 4| 5| 6| 3|                                                  |            |
                                           | 1| 1| 7| 0| 1| 5| 3| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |     A      |
    0.6MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |     L      |
                                           | 1| 2| 3| 4| 6| 7| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  M  +                                                   |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  57        |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |       X                                                                  |         15 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          2 |
      Hepatocellular Adenoma               | X     X                                                                  |          8 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |  57        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  57        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  57        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +                                                   |  57        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  63                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 1| 7|                                                  |            |
                             DAY ON TEST   | 4| 4| 3| 4| 4| 5| 6| 3|                                                  |            |
                                           | 1| 1| 7| 0| 1| 5| 3| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |     A      |
    0.6MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |     L      |
                                           | 1| 2| 3| 4| 6| 7| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +                                                   |  57        |
      Leiomyoma                            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +                                                   |  52        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +                                                   |  55        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  I  M  M  M  M                                                   |  18        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  56        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +                                                   |  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  55        |
      Prepuce, Fibrous Histiocytoma        |                                                                          |          1 |
      Tail, Hemangiosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  64                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 1| 7|                                                  |            |
                             DAY ON TEST   | 4| 4| 3| 4| 4| 5| 6| 3|                                                  |            |
                                           | 1| 1| 7| 0| 1| 5| 3| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2|                                                  |     A      |
    0.6MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |     L      |
                                           | 1| 2| 3| 4| 6| 7| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  57        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          6 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +                                                   |  57        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +                                                   |  57        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  65                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0|                                                                    |            |
                             DAY ON TEST   | 7| 3|                                                                    |            |
                                           | 5| 7|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 1| 2|                                                                    |     A      |
    0.6MG/M3                               | 9| 2|                                                                    |     L      |
    LUNG TOX                               | 3| 3|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |   2        |
      Adenoma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M                                                                     |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  66                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0|                                                                    |            |
                             DAY ON TEST   | 7| 3|                                                                    |            |
                                           | 5| 7|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 1| 2|                                                                    |     A      |
    0.6MG/M3                               | 9| 2|                                                                    |     L      |
    LUNG TOX                               | 3| 3|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | I  M                                                                     |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M                                                                     |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  67                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 3| 0| 4|             
                                           | 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
                                           | 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |             X           X              X        X                    X   |             
      Hepatocellular Adenoma               |          X        X           X                    X           X         |             
      Hepatocellular Adenoma, Multiple     |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Odontoma                             |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic            |                                                                          |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  68                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 3| 0| 4|             
                                           | 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
                                           | 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Interstitium, Granular Cell Tumor NOS|                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                         +           +                 +              +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                             +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | I  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Stomach, |                                                                          |             
           Glandular                       |                                                       X                  |             
      Fibrous Histiocytoma                 |                                                                          |             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  M  M  M  I  +  M  I  +  I  I  +  +  +  +  +  M  I  +  M  I  M  M  M  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  M  I  +  +  M  M  M  +  M  +  +  M  I  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Pinna, Hemangiosarcoma               |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  69                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 3| 0| 4|             
                                           | 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
                                           | 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Hepatoblastoma, Metastatic, Liver    |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatoblastoma, Metastatic, Liver    |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +                                +  +     +        +              +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  70                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 3|             
                             DAY ON TEST   | 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3| 3| 3|             
                                           | 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Hepatoblastoma                       |                                              X                           |             
      Hepatocellular Carcinoma             |       X        X              X              X                    X      |             
      Hepatocellular Adenoma               |       X           X        X     X                       X     X         |             
      Hepatocellular Adenoma, Multiple     |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Odontoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic            | X                                                                        |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic            | X                                                                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  71                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 3|             
                             DAY ON TEST   | 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3| 3| 3|             
                                           | 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Interstitium, Granular Cell Tumor NOS|                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |    +  +           +                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    A                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +     +  +  +              +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Stomach, |                                                                          |             
           Glandular                       |                                                                          |             
      Fibrous Histiocytoma                 |                               X                                          |             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  I  A  M  M  +  M  I  +  M  +  M  I  M  I  +  +  +  +  I  +  I  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemangioma                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  M  +  M  +  I  +  +  +  +  +  +  +  +  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                             X            |             
      Pinna, Hemangiosarcoma               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  72                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 3|             
                             DAY ON TEST   | 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3| 3| 3|             
                                           | 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       | X                                                     X                  |             
      Hepatoblastoma, Metastatic, Liver    |                                              X                           |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatoblastoma, Metastatic, Liver    |                                              X                           |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                       +                                +        +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  73                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7|                                                  |            |
                             DAY ON TEST   | 3| 4| 1| 3| 3| 4| 7| 3|                                                  |            |
                                           | 7| 0| 3| 9| 7| 0| 6| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |     A      |
    1.2MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0|                                                  |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +                                                   |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  +  A  M                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +                                                   |  54        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  A  +                                                   |  57        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |       X  X                                                               |         12 |
      Hepatocellular Adenoma               |                                                                          |         11 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  A  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +                                                   |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +                                                   |  55        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |   4        |
      Odontoma                             |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  58        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  A  +                                                   |  56        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  A  +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +                                                   |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  A  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  A  M                                                   |  53        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  A  +                                                   |  57        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  74                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7|                                                  |            |
                             DAY ON TEST   | 3| 4| 1| 3| 3| 4| 7| 3|                                                  |            |
                                           | 7| 0| 3| 9| 7| 0| 6| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |     A      |
    1.2MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0|                                                  |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic            |                                                                          |          1 |
      Thoracic, Alveolar/Bronchiolar       |                                                                          |            |
          Carcinoma, Metastatic            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |       +                                                                  |   1        |
      Interstitium, Granular Cell Tumor NOS|       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  A  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Penis                                   |          +                                                               |   8        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +                                                   |  58        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  A  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  A  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  A  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  A  +                                                   |  53        |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  A  +                                                   |  55        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +                                                   |  53        |
      Adenocarcinoma, Metastatic, Stomach, |                                                                          |            |
           Glandular                       |                                                                          |          1 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Hemangioma                           |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | I  I  M  +  I  I  A  M                                                   |  17        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +                                                   |  55        |
      Hemangioma                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  A  +                                                   |  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M                                                   |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  A  +                                                   |  57        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Pinna, Hemangiosarcoma               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  75                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 6| 7|                                                  |            |
                             DAY ON TEST   | 3| 4| 1| 3| 3| 4| 7| 3|                                                  |            |
                                           | 7| 0| 3| 9| 7| 0| 6| 7|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4|                                                  |     A      |
    1.2MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0|                                                  |     L      |
                                           | 1| 3| 4| 5| 6| 7| 8| 0|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  A  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  A  +                                                   |  57        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  A  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  A  +                                                   |  56        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |          4 |
      Hepatoblastoma, Metastatic, Liver    |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  A  +                                                   |  57        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  M  +  +  M  +                                                   |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +                                                   |  57        |
      Hepatoblastoma, Metastatic, Liver    |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +                                                   |  56        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +                                                   |  58        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  76                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1|                                                                    |            |
                             DAY ON TEST   | 9| 1|                                                                    |            |
                                           | 1| 8|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 3| 3|                                                                    |     A      |
    1.2MG/M3                               | 5| 9|                                                                    |     L      |
    LUNG TOX                               | 8| 9|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M                                                                     |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  77                                                               
NTP Experiment-Test: 05107-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:10:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1|                                                                    |            |
                             DAY ON TEST   | 9| 1|                                                                    |            |
                                           | 1| 8|                                                                    |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0|                                                                    |     O      |
   B6C3F1 MICE MALE                        | 0| 0|                                                                    |     T      |
                               ANIMAL ID   | 3| 3|                                                                    |     A      |
    1.2MG/M3                               | 5| 9|                                                                    |     L      |
    LUNG TOX                               | 8| 9|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | A  M                                                                     |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M                                                                     |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  78                                                               
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