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TDMS Study 05107-06 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         NICKEL SUBSULFIDE


NTP Experiment-Test: 05107-06                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20           60           20           60           20           
  Scheduled Sacrifice                                  2           18                        20            2           18           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14                        15                        11            2           
    Natural Death                                      8                        11                         9                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                36                        34                        38                        
  Other                                                             2                                                               
  Animals Examined Microscopically                    58           10           60           10           58           12           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (5)          (51)         (5)          (51)         (7)          
   Intestine Large, Colon                             (56)         (5)          (55)         (5)          (52)         (7)          
   Intestine Large, Cecum                             (54)         (5)          (54)         (5)          (53)         (7)          
   Intestine Small, Duodenum                          (53)         (5)          (53)         (5)          (51)         (7)          
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (54)         (5)          (53)         (5)          (51)         (7)          
      Adenoma                                                                                              1 (2%)                   
   Liver                                              (58)         (5)          (60)         (5)          (58)         (7)          
      Hemangioma                                                    1 (20%)                                                         
      Hemangiosarcoma                                  2 (3%)                    1 (2%)                    1 (2%)       1 (14%)     
      Hepatocellular Carcinoma                        11 (19%)                   8 (13%)                   4 (7%)                   
      Hepatocellular Carcinoma, Multiple                                         1 (2%)                                             
      Hepatocellular Adenoma                           9 (16%)      1 (20%)      8 (13%)                   9 (16%)                  
      Hepatocellular Adenoma, Multiple                 4 (7%)                    2 (3%)                    1 (2%)                   
      Histiocytic Sarcoma                                                        2 (3%)                    1 (2%)       1 (14%)     
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Mesentery                                          (3)                       (4)                       (1)                       
      Carcinoma, Metastatic, Islets, Pancreatic        1 (33%)                                                                      
      Histiocytic Sarcoma                                                                                  1 (100%)                 
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (25%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (25%)                                            
   Oral Mucosa                                                                                            (1)                       
      Buccal, Squamous Cell Papilloma                                                                      1 (100%)                 
   Pancreas                                           (58)         (5)          (56)         (5)          (57)         (7)          
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
                                                             Page   2                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
           Forestomach                                                           1 (2%)                                             
   Salivary Glands                                    (58)         (5)          (60)         (5)          (58)         (7)          
   Stomach, Forestomach                               (57)         (5)          (60)         (5)          (56)         (7)          
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (57)         (5)          (58)         (5)          (56)         (7)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (5)          (60)         (5)          (57)         (7)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (5)          (58)         (5)          (58)         (7)          
      Adenoma                                          1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                    1 (2%)                   
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Adrenal Medulla                                    (58)         (5)          (58)         (5)          (58)         (7)          
      Pheochromocytoma Benign                          1 (2%)                                              1 (2%)                   
   Islets, Pancreatic                                 (58)         (5)          (56)         (5)          (57)         (7)          
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (58)         (4)          (57)         (5)          (58)         (7)          
      Pars Distalis, Adenoma                           8 (14%)                   5 (9%)                    3 (5%)                   
   Thyroid Gland                                      (58)         (5)          (60)         (5)          (58)         (7)          
      Follicular Cell, Adenoma                         2 (3%)                    4 (7%)                    3 (5%)                   
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (4)                       (1)          (1)          
      Histiocytic Sarcoma                                                        1 (25%)                                            
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (25%)                                            
      Mediastinum, Hemangiosarcoma                                               1 (25%)                                            
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
                                                             Page   3                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENERAL BODY SYSTEM - cont                                                                                                          
           Metastatic, Lung                                                      1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (58)         (4)          (58)         (5)          (58)         (7)          
      Cystadenoma                                      2 (3%)                                              1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Luteoma                                                                    1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
      Teratoma Benign                                                            1 (2%)                                             
      Teratoma Malignant                                                         1 (2%)                                             
   Uterus                                             (58)         (5)          (60)         (5)          (58)         (8)          
      Fibroma                                                                                              1 (2%)                   
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (3%)                    1 (2%)                    1 (2%)                   
      Polyp Stromal                                    1 (2%)                    1 (2%)                    1 (2%)       1 (13%)     
      Endometrium, Adenocarcinoma                                                                          1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (57)         (5)          (60)         (5)          (57)         (7)          
      Hemangiosarcoma, Metastatic, Tissue NOS                                    1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
   Lymph Node                                         (9)                       (12)         (1)          (11)                      
      Iliac, Hemangiosarcoma                           1 (11%)                                                                      
      Iliac, Sarcoma, Metastatic, Skeletal Muscle                                                          1 (9%)                   
      Pancreatic, Histiocytic Sarcoma                                            1 (8%)                                             
      Pancreatic, Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                                                           1 (9%)                   
      Pancreatic, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach, Forestomach                                       1 (8%)                                             
      Renal, Histiocytic Sarcoma, Metastatic,                                                                                       
          Uterus                                       1 (11%)                                                                      
      Renal, Sarcoma, Metastatic, Skeletal Muscle                                                          1 (9%)                   
   Lymph Node, Bronchial                              (50)         (10)         (57)         (9)          (58)         (11)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (57)         (7)          (59)         (7)          (58)         (10)         
   Lymph Node, Mesenteric                             (55)         (5)          (54)         (5)          (55)         (7)          
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                                                                 1 (2%)                   
   Lymph Node, Mediastinal                            (15)                      (28)                      (29)         (3)          
      Histiocytic Sarcoma, Metastatic, Uterus          1 (7%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (4%)                                             
   Spleen                                             (58)         (5)          (60)         (5)          (58)         (7)          
      Fibrosarcoma                                     1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                    1 (2%)                   
      Hemangiosarcoma, Metastatic, Tissue NOS                                    1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                    1 (2%)                   
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Teratoma Malignant, Metastatic, Ovary                                      1 (2%)                                             
   Thymus                                             (58)         (5)          (57)         (5)          (53)         (6)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (5)          (59)         (5)          (58)         (7)          
      Adenocarcinoma                                   1 (2%)                    3 (5%)                                             
   Skin                                               (58)         (5)          (60)         (5)          (58)         (7)          
      Fibroma                                                                                              1 (2%)                   
      Fibrosarcoma                                                                                         1 (2%)                   
      Keratoacanthoma                                                            1 (2%)                                             
      Pinna, Fibrosarcoma                              2 (3%)                                              1 (2%)                   
      Pinna, Squamous Cell Carcinoma                                                                       1 (2%)                   
      Sebaceous Gland, Squamous Cell Carcinoma                                                             1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (57)         (5)          (60)         (5)          (57)         (7)          
      Hemangiosarcoma                                                                                      1 (2%)                   
   Skeletal Muscle                                    (1)                       (3)                       (1)                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (100%)                                                                     
      Hemangiosarcoma                                                            1 (33%)                                            
      Hemangiosarcoma, Metastatic, Spleen                                        1 (33%)                                            
      Sarcoma                                                                    1 (33%)                   1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (5)          (60)         (5)          (58)         (7)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (54)         (4)          (55)         (4)          (51)         (6)          
      Epithelium, Squamous Cell Carcinoma                                        1 (2%)                                             
   Lung                                               (58)         (10)         (59)         (10)         (58)         (12)         
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     3 (5%)                    1 (2%)                    1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                   7 (12%)                   1 (2%)                    2 (3%)                   
      Hepatocellular Carcinoma, Metastatic             1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                    6 (10%)                   1 (2%)                   
      Histiocytic Sarcoma                                                        1 (2%)                                 1 (8%)      
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Nose                                               (58)         (10)         (59)         (10)         (58)         (12)         
      Hemangioma                                                                                           1 (2%)                   
   Trachea                                            (57)         (5)          (57)         (5)          (56)         (7)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                 (1)                       
      Adenoma                                          1 (100%)                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (10)         (60)         (10)         (58)         (12)         
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                                                               1 (8%)      
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
      Teratoma Malignant, Metastatic, Ovary                                      1 (2%)                                             
   Urinary Bladder                                    (56)         (5)          (55)         (5)          (57)         (7)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(10)        *(60)        *(10)        *(58)        *(12)         
      Histiocytic Sarcoma                              2 (3%)                    2 (3%)                    1 (2%)       1 (8%)      
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(58)        *(10)        *(60)        *(10)        *(58)        *(12)         
      Lymphoma Malignant                               5 (9%)                    7 (12%)                   6 (10%)                  
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42           2          39                      36           3               
     Total Primary Neoplasms                           69           2          55                      48           3               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27           2          22                      20           1               
     Total Benign Neoplasms                            35           2          25                      26           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26                      27                      21           2               
     Total Malignant Neoplasms                         34                      30                      22           2               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7                      12                       2                           
     Total Metastatic Neoplasm                         18                      37                       7                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   8                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20           60           20           60           20           
  Scheduled Sacrifice                                  1           18            2           18            2           18           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27                        25            1           25            1           
    Natural Death                                      6            2            8            1            8            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                26                        25                        25                        
  Animals Examined Microscopically                    59           12           59           11           58           12           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (56)         (6)          (50)         (5)          (53)         (5)          
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
   Intestine Small, Duodenum                          (56)         (5)          (51)         (5)          (53)         (6)          
      Adenoma                                          1 (2%)                                                                       
   Intestine Small, Jejunum                           (56)         (5)          (51)         (5)          (53)         (6)          
   Intestine Small, Ileum                             (55)         (5)          (51)         (5)          (54)         (6)          
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
   Liver                                              (59)         (7)          (58)         (6)          (57)         (7)          
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                                                                      1 (2%)                   
      Hepatoblastoma                                                                                       1 (2%)                   
      Hepatocellular Carcinoma                        10 (17%)      1 (14%)     15 (26%)                  12 (21%)      1 (14%)     
      Hepatocellular Carcinoma, Multiple                                         2 (3%)                                             
      Hepatocellular Adenoma                          11 (19%)      1 (14%)      8 (14%)      2 (33%)     11 (19%)      1 (14%)     
      Hepatocellular Adenoma, Multiple                 2 (3%)                    1 (2%)                    3 (5%)                   
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
   Mesentery                                          (1)                                                                           
      Fibrous Histiocytoma, Metastatic, Liver          1 (100%)                                                                     
   Pancreas                                           (59)         (7)          (58)         (6)          (56)         (7)          
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
   Salivary Glands                                    (59)         (7)          (58)         (6)          (57)         (7)          
   Stomach, Glandular                                 (59)         (7)          (58)         (6)          (55)         (7)          
      Adenocarcinoma                                                                                       1 (2%)                   
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
   Tooth                                              (4)                       (1)                       (4)                       
      Odontoma                                                                                             2 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (7)          (58)         (6)          (58)         (7)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (7)          (58)         (6)          (56)         (7)          
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Capsule, Adenoma                                 2 (3%)                                              1 (2%)                   
   Adrenal Medulla                                    (58)         (7)          (58)         (6)          (54)         (7)          
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Pheochromocytoma Complex                         1 (2%)                                                                       
   Islets, Pancreatic                                 (59)         (7)          (58)         (6)          (56)         (7)          
      Adenoma                                          1 (2%)                                 1 (17%)                               
   Pituitary Gland                                    (56)         (7)          (57)         (6)          (53)         (7)          
      Pars Distalis, Adenoma                                                                               1 (2%)                   
   Thyroid Gland                                      (59)         (7)          (58)         (6)          (57)         (7)          
      Follicular Cell, Adenoma                         4 (7%)                    1 (2%)                    1 (2%)                   
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                 (1)                       
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic                                                                                      1 (100%)                 
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic                                                                                      1 (100%)                 
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic, Lung                            1 (100%)                                                                     
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                                                      (1)                       
      Interstitium, Granular Cell Tumor NOS                                                                1 (100%)                 
   Epididymis                                         (59)         (7)          (58)         (6)          (57)         (7)          
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Leiomyoma                                                                  1 (2%)                                             
   Seminal Vesicle                                    (59)         (7)          (58)         (6)          (57)         (7)          
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
   Testes                                             (59)         (7)          (58)         (6)          (57)         (7)          
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
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                                                             Page  10                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (18)         (1)          (11)         (2)          (10)         (1)          
      Axillary, Fibrosarcoma, Metastatic, Skin         1 (6%)                                                                       
      Pancreatic, Fibrous Histiocytoma, Metastatic,                                                                                 
           Liver                                       1 (6%)                                                                       
   Lymph Node, Bronchial                              (39)         (8)          (53)         (7)          (53)         (11)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic                                                                 1 (2%)                   
   Lymph Node, Mesenteric                             (56)         (7)          (56)         (6)          (53)         (7)          
      Adenocarcinoma, Metastatic, Stomach,                                                                                          
          Glandular                                                                                        1 (2%)                   
      Fibrous Histiocytoma                                                                                 1 (2%)                   
      Hemangioma                                       1 (2%)                                              1 (2%)                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Lymph Node, Mediastinal                            (12)         (3)          (18)         (3)          (17)         (5)          
   Spleen                                             (59)         (7)          (57)         (6)          (55)         (7)          
      Hemangioma                                                                                           1 (2%)                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (46)         (7)          (50)         (5)          (39)         (7)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (7)          (56)         (6)          (57)         (7)          
      Fibrosarcoma                                     1 (2%)                                                                       
      Fibrous Histiocytoma                                                                                 1 (2%)                   
      Pinna, Hemangiosarcoma                                                                               1 (2%)                   
      Prepuce, Fibrous Histiocytoma                                              1 (2%)                                             
      Tail, Hemangiosarcoma                                                      1 (2%)                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
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                                                             Page  11                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (12)         (58)         (11)         (56)         (12)         
      Alveolar/Bronchiolar Adenoma                     5 (8%)                    3 (5%)                    2 (4%)                   
      Alveolar/Bronchiolar Adenoma, Two                1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   7 (12%)                   2 (3%)                    4 (7%)                   
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                                                                    1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                    6 (10%)                   2 (4%)                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Pheochromocytoma Complex, Metastatic,                                                                                         
          Adrenal Medulla                              1 (2%)                                                                       
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                                           
      Adenoma                                          1 (100%)                                                                     
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (12)         (58)         (11)         (57)         (12)         
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                                                                    1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
      Pelvis, Hemangiosarcoma                          1 (2%)                                                                       
   Urinary Bladder                                    (59)         (7)          (58)         (7)          (56)         (7)          
      Leiomyosarcoma                                   1 (2%)                                                                       
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(59)        *(12)        *(59)        *(11)        *(58)        *(12)         
      Lymphoma Malignant                               1 (2%)                    1 (2%)                                             
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05107-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39           2          30           3          35           1               
     Total Primary Neoplasms                           55           2          39           3          46           2               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27           1          14           3          19           1               
     Total Benign Neoplasms                            30           1          15           3          23           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20           1          23                      20           1               
     Total Malignant Neoplasms                         25           1          24                      22           1               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7                       6                       4                           
     Total Metastatic Neoplasm                         20                       6                      10                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                  1                           
     Total Uncertain Neoplasms                                                                          1                           
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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