National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1869

TDMS Study 05107-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: LITRI                                                  NICKEL SUBSULFIDE                                  DATE: 05/19/95       
EXPERIMENT: 05107 TEST: 06                                                                                     TIME: 23:03:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: Y01ES30108                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C61654       
PATHOLOGIST: F. HAHN                                                                                           CAS: 12035722        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: LITRI                                                  NICKEL SUBSULFIDE                                  DATE: 05/19/95      
EXPERIMENT: 05107 TEST: 06                                                                                     TIME: 23:03:13      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: Y01ES30108                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C61654      
PATHOLOGIST: F. HAHN                                                                                           CAS: 12035722       

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 33     CENSORED DEATHS 1    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      212   313   406   463   480   499   508   526   536   544                 |
 |      552   552   557   561   584   584   585   586   588   589                 |
 |      591   605   620   631   641   662   679   681   681   681                 |
 |      694   713   719                                                           |
 |  CENSORED DEATHS                                                               |
 |      476                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 2      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      67    434                                                                 |
 |  CENSORED DEATHS                                                               |
 |      196   196   196   196   196   196   196   196   196   476                 |
 |      476   476   476   476   476   476   476   476                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.6MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 33     CENSORED DEATHS 2    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      20    163   244   355   415   469   469   484   513   521                 |
 |      525   533   549   549   559   563   570   580   581   588                 |
 |      590   592   618   620   636   661   671   674   686   692                 |
 |      704   716   731                                                           |
 |  CENSORED DEATHS                                                               |
 |      476   476                                                                 |
 |                                                                                |
 ==================================================================================

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.6MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 2      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      37    475                                                                 |
 |  CENSORED DEATHS                                                               |
 |      196   196   196   196   196   196   196   196   196   196                 |
 |      476   476   476   476   476   476   476   476                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.2MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 33     CENSORED DEATHS 2    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      144   250   335   374   385   424   450   459   463   469                 |
 |      485   524   532   539   585   607   607   626   642   644                 |
 |      661   661   661   665   665   666   676   695   705   711                 |
 |      713   716   734                                                           |
 |  CENSORED DEATHS                                                               |
 |      476   476                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.2MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 2      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      118   391                                                                 |
 |  CENSORED DEATHS                                                               |
 |      196   196   196   196   196   196   196   196   196   196                 |
 |      476   476   476   476   476   476   476   476                             |
 |                                                                                |
 ==================================================================================

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0MG/M3   |   100.0 100.0  98.3  96.7  95.0  91.6  83.2  62.8  56.0  44.1      |
 |           |                                                                    |
 |           |                                                                    |
 |0.0MG/M3LUN|    95.0  95.0  95.0  95.0  95.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.6MG/M3   |    98.3  96.7  95.0  93.3  91.7  86.6  79.7  62.4  55.4  43.3      |
 |           |                                                                    |
 |           |                                                                    |
 |0.6MG/M3LUN|    95.0  95.0  95.0  95.0  95.0   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |1.2MG/M3   |   100.0  98.3  96.7  95.0  90.0  81.6  76.4  74.7  57.3  43.4      |
 |           |                                                                    |
 |           |                                                                    |
 |1.2MG/M3LUN|   100.0  95.0  95.0  95.0  84.4   0.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                          DOSE                                               |
 |                                                                                                                             |
 |                                0.0MG/M3        0.0MG/M3LUNG    0.6MG/M3        0.6MG/M3LUNG    1.2MG/M3        1.2MG/M3LUNG |
 |                                                TOX                             TOX                             TOX          |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       44.1%            0.0%           43.3%            0.0%           43.4%            0.0%        |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=1.000          -----          P=0.926         P=0.510         P=1.000         P=0.481      |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       570.4           250.5           540.6           256.0           559.8           254.5        |
 |NATURAL DEATHS (C)      |       (19.1)          ( 184)          (27.3)          ( 219)          (25.6)          ( 137)       |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       641.0           327.5           620.3           314.0           630.8           313.9        |
 |(STANDARD ERROR)        |       (15.2)          (33.8)          (19.7)          (34.5)          (18.3)          (32.2)       |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 2    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      288   300   385   419   508   536   552   563   598   600                 |
 |      603   645   649   674   679   680   683   691   694   696                 |
 |      723   727                                                                 |
 |  CENSORED DEATHS                                                               |
 |      477   477                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.0MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 18     UNCENSORED DEATHS 0      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      197   197   197   197   197   197   197   197   197   197                 |
 |      477   477   477   477   477   477   477   477                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.6MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      112   116   206   403   425   520   530   536   552   563                 |
 |      605   623   636   642   652   653   655   655   655   692                 |
 |      694   711   712   717   720   728                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.6MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      197   197   197   197   197   197   197   197   197   197                 |
 |      477   477   477   477   477   477   477   477   477   477                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.2MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 2    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      239   340   499   507   563   580   580   580   588   607                 |
 |      628   630   632   653   672   685   703   729   732   732                 |
 |  CENSORED DEATHS                                                               |
 |      477   477                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.2MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 2      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      74    445                                                                 |
 |  CENSORED DEATHS                                                               |
 |      197   197   197   197   197   197   197   197   197   197                 |
 |      477   477   477   477   477   477   477   477                             |
 |                                                                                |
 ==================================================================================

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0MG/M3   |   100.0 100.0 100.0  96.7  93.3  93.3  89.9  81.2  77.8  62.2      |
 |           |                                                                    |
 |           |                                                                    |
 |0.0MG/M3LUN|   100.0 100.0 100.0 100.0 100.0 100.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |0.6MG/M3   |   100.0  96.7  95.0  95.0  91.7  91.7  86.7  81.7  68.3  56.7      |
 |           |                                                                    |
 |           |                                                                    |
 |0.6MG/M3LUN|   100.0 100.0 100.0 100.0 100.0 100.0   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 |1.2MG/M3   |   100.0 100.0  98.3  96.7  96.7  96.7  93.2  84.6  76.0  65.6      |
 |           |                                                                    |
 |           |                                                                    |
 |1.2MG/M3LUN|    95.0  95.0  95.0  95.0  95.0  84.4   0.0   0.0   0.0   0.0      |
 |TOX        |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 NICKEL SUBSULFIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                          DOSE                                               |
 |                                                                                                                             |
 |                                0.0MG/M3        0.0MG/M3LUNG    0.6MG/M3        0.6MG/M3LUNG    1.2MG/M3        1.2MG/M3LUNG |
 |                                                TOX                             TOX                             TOX          |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.2%            0.0%           56.7%            0.0%           65.6%            0.0%        |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.979N         -----          P=0.643         P=0.905N        P=0.808N        P=0.510      |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       586.0              .            565.9              .            594.0           259.5        |
 |NATURAL DEATHS (C)      |       (28.1)          (  . )          (34.9)          (  . )          (28.0)          ( 186)       |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       670.6           321.4           660.6           337.0           678.1           315.3        |
 |(STANDARD ERROR)        |       (14.4)          (33.7)          (18.4)          (32.1)          (13.4)          (33.4)       |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         NICKEL SUBSULFIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0MG/M3         = 1
                                                        0.0MG/M3LUNG TOX = 2
                                                        0.6MG/M3         = 3
                                                        0.6MG/M3LUNG TOX = 4
                                                        1.2MG/M3         = 5
                                                        1.2MG/M3LUNG TOX = 6

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100 + 1  3   4   2       6   5          1
      |    3                   5  3       1    35         1  5          1
      |        4   2       6                   3             5  3  5  6 1   2     14
      |                                                         3  5 5    35      1 1  1
   90 +                                                                    5    5      11
      |                                                                         553  3  13  11
      |                                                               6     2      42    3 3 11
      |                                                                           5  5     3 311
   80 +                                                                                    553 11
      |                                                                                     55  11  1
      |                                                                                        333  5   5
      |                                                                                          33
P  70 +                                                                                           33    5  5 5
E     |                                                                                            31 1
R     |                                                                                             3 1 1    5   5
C     |                                                                                               3 1 1
E  60 +                                                                                                   1 11
N     |                                                                                                     31   15
T     |                                                                                                          1311 5
      |                                                                                                           333 55
S  50 +                                                                                                             13155
U     |                                                                                                              31313
R     |                                                                                                                 11  31
V     |                                                                                                                     33
I  40 +
V     |
A     |
L     |
   30 +
      |
      |
      |
   20 +
      |
      |
      |
   10 +
      |
      |
      |
    0 +                                                                             2
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 52 obs hidden.

                                                         NICKEL SUBSULFIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0MG/M3         = 1
                                                        0.0MG/M3LUNG TOX = 2
                                                        0.6MG/M3         = 3
                                                        0.6MG/M3LUNG TOX = 4
                                                        1.2MG/M3         = 5
                                                        1.2MG/M3LUNG TOX = 6

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100 + 1           6     3                    5      1                                2
      |                   33             3     5      11      5      1                 5
      |             6                    3                           1  3 1   6        55
      |                                                                 3 13            1  3 1   5 5
   90 +                                                                                    331 1
      |                                                                                     33 1 1 55  1
      |                                                                       6        6       3 3  5   5
      |                                                                                          3     11 35
   80 +                                                                                                 1 353 1
      |                                                                                                     3313   1
      |                                                                                                        5  511
      |                                                                                                             5  5
P  70 +                                                                                                             1115    5
E     |                                                                                                        3     33
R     |                                                                                                               1 3 1 5
C     |                                                                                                                 331 1
E  60 +
N     |                                                                                                                  33 3
T     |
      |
S  50 +
U     |
R     |
V     |
I  40 +
V     |
A     |
L     |
   30 +
      |
      |
      |
   20 +
      |
      |
      |
   10 +
      |
      |
      |
    0 +                                                                                2
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 31 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.