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TDMS Study 05107-05 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         NICKEL SUBSULFIDE


NTP Experiment-Test: 05107-05                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  09/30/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                  2            5            2            5            2            5           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24                        27                        23                        
    Natural Death                                      4                         1                         1                        
    Accidently Killed                                                                                      1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                        25                        28                        
  Animals Examined Microscopically                    58            5           58            5           58            5           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (55)                      (57)                      (58)                      
      Parasite Metazoan                                                                                    1 (2%)                   
   Intestine Large, Rectum                            (46)                      (43)                      (42)                      
      Parasite Metazoan                                                          2 (5%)                                             
   Intestine Large, Cecum                             (54)                      (57)                      (57)                      
      Inflammation                                     1 (2%)                                                                       
      Parasite Metazoan                                2 (4%)                    2 (4%)                    3 (5%)                   
   Intestine Small, Jejunum                           (55)                      (57)                      (57)                      
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Intestine Small, Ileum                             (55)                      (57)                      (58)                      
      Hyperplasia, Lymphoid                            3 (5%)                    5 (9%)                    3 (5%)                   
   Liver                                              (58)                      (58)                      (58)         (1)          
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                47 (81%)                  49 (84%)                  45 (78%)                  
      Clear Cell Focus                                                           1 (2%)                                             
      Degeneration, Cystic                             1 (2%)                    4 (7%)                    2 (3%)                   
      Degeneration, Fatty                             16 (28%)                  12 (21%)                  11 (19%)                  
      Eosinophilic Focus                               3 (5%)                    2 (3%)                    5 (9%)                   
      Granuloma                                                                                            1 (2%)                   
      Hematopoietic Cell Proliferation                                           1 (2%)                    1 (2%)                   
      Hepatodiaphragmatic Nodule                       7 (12%)                   4 (7%)                    2 (3%)                   
      Inflammation, Focal, Granulomatous              24 (41%)                  22 (38%)                  13 (22%)                  
      Inflammation, Granulomatous                      4 (7%)                    2 (3%)                    5 (9%)                   
      Mixed Cell Focus                                 3 (5%)                    1 (2%)                    1 (2%)                   
      Pigmentation, Hemosiderin                        3 (5%)                    1 (2%)                    7 (12%)                  
      Regeneration                                                                                         2 (3%)                   
      Bile Duct, Hyperplasia                          18 (31%)                  13 (22%)                  14 (24%)                  
      Biliary Tract, Hyperplasia                       1 (2%)                                                                       
      Centrilobular, Atrophy                           9 (16%)                   5 (9%)                   14 (24%)                  
      Hepatocyte, Atrophy                                                                                  1 (2%)                   
      Hepatocyte, Hyperplasia                          4 (7%)                    1 (2%)                    1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Necrosis                             1 (2%)                    1 (2%)                                             
      Vein, Thrombosis                                                                                     1 (2%)                   
   Mesentery                                          (1)                                                 (2)                       
      Necrosis                                                                                             1 (50%)                  
      Fat, Necrosis                                    1 (100%)                                                                     
   Pancreas                                           (58)                      (57)                      (58)                      
      Atrophy                                         10 (17%)                   4 (7%)                   14 (24%)                  
   Stomach, Forestomach                               (58)                      (58)                      (58)                      
      Hyperplasia, Squamous                            2 (3%)                    5 (9%)                    2 (3%)                   
      Inflammation                                     1 (2%)                                                                       
      Ulcer                                            3 (5%)                    1 (2%)                                             
   Tooth                                              (1)                       (1)                                                 
      Peridontal Tissue, Inflammation                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                                           (1)                       
      Inflammation                                                                                         1 (100%)                 
   Heart                                              (58)                      (58)                      (58)                      
      Cardiomyopathy                                  25 (43%)                  17 (29%)                  18 (31%)                  
      Atrium, Thrombosis                               2 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)                      (58)                      (58)                      
      Degeneration, Cystic                            11 (19%)                  11 (19%)                  19 (33%)                  
      Hyperplasia                                                                                          2 (3%)                   
      Hyperplasia, Focal                               1 (2%)                                              5 (9%)                   
      Necrosis                                                                                             2 (3%)                   
      Vacuolization Cytoplasmic                        4 (7%)                    3 (5%)                    6 (10%)                  
   Adrenal Medulla                                    (58)                      (56)                      (58)                      
      Hyperplasia                                      5 (9%)                   11 (20%)                  16 (28%)                  
   Islets, Pancreatic                                 (58)                      (58)                      (58)                      
      Hyperplasia                                                                1 (2%)                    1 (2%)                   
   Parathyroid Gland                                  (52)                      (55)                      (54)                      
      Hyperplasia                                      1 (2%)                    2 (4%)                    3 (6%)                   
   Pituitary Gland                                    (57)                      (58)                      (58)                      
      Cyst                                                                       1 (2%)                                             
      Pars Distalis, Angiectasis                      21 (37%)                  11 (19%)                  16 (28%)                  
      Pars Distalis, Cyst                              3 (5%)                    3 (5%)                                             
      Pars Distalis, Hyperplasia                      13 (23%)                   5 (9%)                   14 (24%)                  
   Thyroid Gland                                      (56)                      (58)                      (57)                      
      C-Cell, Hyperplasia                             16 (29%)                  12 (21%)                  12 (21%)                  
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)                      (57)                      (57)                      
      Hyperplasia, Cystic                              6 (11%)                   5 (9%)                    5 (9%)                   
      Inflammation                                                               1 (2%)                                             
   Ovary                                              (58)         (1)          (58)         (1)          (58)         (1)          
      Atrophy                                                                                              1 (2%)                   
      Cyst                                             5 (9%)       1 (100%)     3 (5%)       1 (100%)     6 (10%)      1 (100%)    
      Inflammation                                                                                         2 (3%)                   
   Uterus                                             (58)                      (58)                      (58)                      
      Cyst                                             1 (2%)                                                                       
      Inflammation                                                                                         1 (2%)                   
      Endometrium, Hyperplasia, Cystic                 3 (5%)                    1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)                      (58)                      (58)                      
      Atrophy                                          2 (3%)                                                                       
      Fibrosis                                         2 (3%)                                              3 (5%)                   
      Inflammation, Focal, Granulomatous               4 (7%)                                              1 (2%)                   
      Necrosis                                                                                             1 (2%)                   
      Erythroid Cell, Hyperplasia                                                1 (2%)                                             
      Myeloid Cell, Hyperplasia                                                  2 (3%)                    2 (3%)                   
   Lymph Node                                         (5)                       (3)                       (10)                      
      Pancreatic, Hyperplasia, Lymphoid                                          1 (33%)                   1 (10%)                  
      Pancreatic, Hyperplasia, Macrophage                                                                  1 (10%)                  
      Renal, Hyperplasia, Lymphoid                     1 (20%)                                                                      
   Lymph Node, Bronchial                              (55)         (5)          (54)         (5)          (55)         (5)          
      Hemorrhage, Acute                                                          1 (2%)                                             
      Hyperplasia, Lymphoid                           11 (20%)      2 (40%)     37 (69%)      2 (40%)     38 (69%)      5 (100%)    
      Hyperplasia, Macrophage                          1 (2%)                   18 (33%)                  28 (51%)                  
      Hyperplasia, Plasma Cell                                                                             2 (4%)                   
      Inflammation                                                                                         1 (2%)                   
   Lymph Node, Mandibular                             (49)                      (53)                      (56)                      
      Hyperplasia, Lymphoid                            3 (6%)                    5 (9%)                    1 (2%)                   
      Hyperplasia, Plasma Cell                         3 (6%)                    6 (11%)                   4 (7%)                   
   Lymph Node, Mesenteric                             (57)                      (58)                      (57)                      
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                            3 (5%)                    5 (9%)                    6 (11%)                  
      Hyperplasia, Macrophage                          1 (2%)                                              3 (5%)                   
   Lymph Node, Mediastinal                            (51)         (5)          (55)         (4)          (52)         (5)          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                                         1 (20%)     11 (20%)      1 (25%)     21 (40%)      5 (100%)    
      Hyperplasia, Macrophage                          1 (2%)                    5 (9%)                    7 (13%)                  
   Spleen                                             (58)                      (58)                      (58)                      
      Atrophy                                                                    1 (2%)                                             
      Fibrosis                                         2 (3%)                                              2 (3%)                   
      Hematopoietic Cell Proliferation                                           3 (5%)                    3 (5%)                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                        7 (12%)                  12 (21%)                   2 (3%)                   
   Thymus                                             (54)                      (56)                      (55)                      
      Degeneration                                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)                      (58)                      (58)                      
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia, Cystic                             11 (19%)                  14 (24%)                  16 (28%)                  
   Skin                                               (58)                      (58)                      (58)                      
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation                                     1 (2%)                                              1 (2%)                   
      Ulcer                                                                      1 (2%)                    1 (2%)                   
      Tail, Hyperkeratosis                             1 (2%)                                                                       
      Tail, Inflammation                               1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                      (58)                      (58)                      
      Hyperostosis                                     5 (9%)                    3 (5%)                    7 (12%)                  
      Cranium, Hyperostosis                                                                                3 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)                      (58)                      (58)                      
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                    1 (2%)                    1 (2%)                    2 (3%)                   
      Cerebrum, Compression                            5 (9%)                   10 (17%)                   5 (9%)                   
      Gray Matter, Necrosis                                                                                1 (2%)                   
   Spinal Cord                                                                  (1)                                                 
      Degeneration, Secondary Wallerian                                          1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (57)                      (58)                      (56)                      
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation                                     2 (4%)                    2 (3%)                    3 (5%)                   
   Lung                                               (58)         (5)          (58)         (5)          (58)         (5)          
      Cyst                                                                                                 1 (2%)                   
      Emphysema                                                                                            1 (2%)                   
      Fibrosis                                                                  50 (86%)                  44 (76%)                  
      Hemorrhage, Acute                                2 (3%)                    3 (5%)                    2 (3%)                   
      Inflammation, Chronic Active                     7 (12%)                  56 (97%)      5 (100%)    56 (97%)      5 (100%)    
      Metaplasia, Osseous                              1 (2%)       1 (20%)      1 (2%)                                             
      Metaplasia, Squamous                                                                                 2 (3%)                   
      Alveolar Epithelium, Hyperplasia, Focal          2 (3%)                   10 (17%)                  11 (19%)                  
      Alveolus, Hyperplasia, Macrophage                9 (16%)                  56 (97%)      5 (100%)    57 (98%)      5 (100%)    
      Alveolus, Proteinosis                            2 (3%)                   54 (93%)      2 (40%)     58 (100%)     5 (100%)    
      Bronchus, Hyperplasia, Lymphoid                                           15 (26%)      1 (20%)     19 (33%)      4 (80%)     
      Interstitium, Infiltration Cellular             28 (48%)      2 (40%)     40 (69%)      5 (100%)    48 (83%)      5 (100%)    
   Nose                                               (58)         (5)          (58)         (5)          (57)         (5)          
      Inflammation, Chronic Active                     9 (16%)      1 (20%)     11 (19%)      2 (40%)     22 (39%)      4 (80%)     
      Thrombosis                                       2 (3%)                                              1 (2%)                   
      Nasolacrimal Duct, Hyperplasia                                             1 (2%)                                             
      Nasolacrimal Duct, Inflammation                  1 (2%)                    2 (3%)                    2 (4%)                   
      Olfactory Epithelium, Atrophy                                                                       17 (30%)                  
      Olfactory Epithelium, Erosion, Focal                          1 (20%)                   2 (40%)                               
      Olfactory Epithelium, Metaplasia                                           1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (2)          (1)          (2)                       
      Cataract                                         2 (100%)                  2 (100%)                  2 (100%)                 
      Retina, Degeneration                             2 (100%)                  1 (50%)                                            
   Lacrimal Gland                                                                                         (1)                       
      Metaplasia, Squamous                                                                                 1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (5)          (58)         (5)          (58)         (5)          
      Cyst                                             1 (2%)                                                                       
      Hydronephrosis                                                                                       1 (2%)                   
      Nephropathy                                     52 (90%)                  54 (93%)                  52 (90%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Pigmentation                      40 (69%)                  43 (74%)                  43 (74%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                  5            5            5            5            5            5           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                35                        28                        33                        
    Natural Death                                      5                         4                         2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                13                        21                        18                        
  Animals Examined Microscopically                    58            5           58            5           58            5           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (56)                      (56)                      (58)                      
      Inflammation                                     3 (5%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Parasite Metazoan                                                          1 (2%)                    1 (2%)                   
   Intestine Large, Rectum                            (51)                      (50)                      (57)                      
      Inflammation                                     1 (2%)                                                                       
      Parasite Metazoan                                4 (8%)                    1 (2%)                    2 (4%)                   
   Intestine Large, Cecum                             (56)                      (54)                      (57)                      
      Hyperplasia, Lymphoid                            1 (2%)                                              1 (2%)                   
      Inflammation                                     2 (4%)                                              4 (7%)                   
      Parasite Metazoan                                1 (2%)                    2 (4%)                    1 (2%)                   
   Intestine Small, Duodenum                          (57)                      (57)                      (58)                      
      Ulcer                                                                                                2 (3%)                   
   Intestine Small, Jejunum                           (56)                      (56)                      (57)                      
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Small, Ileum                             (56)                      (56)                      (57)                      
      Hyperplasia, Lymphoid                            4 (7%)                    5 (9%)                    3 (5%)                   
   Liver                                              (58)                      (58)                      (58)                      
      Angiectasis                                      3 (5%)                    1 (2%)                                             
      Basophilic Focus                                29 (50%)                  35 (60%)                  35 (60%)                  
      Clear Cell Focus                                 1 (2%)                    1 (2%)                                             
      Degeneration, Cystic                            11 (19%)                  15 (26%)                  15 (26%)                  
      Degeneration, Fatty                              9 (16%)                   2 (3%)                    7 (12%)                  
      Eosinophilic Focus                               6 (10%)                   6 (10%)                   6 (10%)                  
      Hepatodiaphragmatic Nodule                       3 (5%)                    2 (3%)                    4 (7%)                   
      Infiltration Cellular, Mononuclear Cell                                                              1 (2%)                   
      Inflammation, Focal, Granulomatous               1 (2%)                    2 (3%)                    1 (2%)                   
      Pigmentation, Hemosiderin                                                                            1 (2%)                   
      Thrombosis                                                                                           1 (2%)                   
      Bile Duct, Hyperplasia                          40 (69%)                  45 (78%)                  39 (67%)                  
      Biliary Tract, Hyperplasia                       1 (2%)                                                                       
      Centrilobular, Atrophy                          12 (21%)                  16 (28%)                  13 (22%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hyperplasia                          3 (5%)                    1 (2%)                    2 (3%)                   
      Hepatocyte, Necrosis                             4 (7%)                    7 (12%)                   4 (7%)                   
   Mesentery                                          (1)                       (1)                       (1)                       
      Inflammation                                                                                         1 (100%)                 
      Fat, Necrosis                                                              1 (100%)                                           
   Pancreas                                           (58)                      (58)                      (58)                      
      Atrophy                                         15 (26%)                  15 (26%)                  25 (43%)                  
      Hyperplasia                                                                1 (2%)                                             
   Salivary Glands                                    (58)                      (57)                      (58)                      
      Infarct                                                                    1 (2%)                    1 (2%)                   
   Stomach, Forestomach                               (58)                      (58)                      (58)                      
      Diverticulum                                                               1 (2%)                                             
      Hyperkeratosis                                   1 (2%)                    3 (5%)                                             
      Hyperplasia, Squamous                            1 (2%)                                              5 (9%)                   
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            4 (7%)                    1 (2%)                    6 (10%)                  
   Stomach, Glandular                                 (58)                      (58)                      (58)                      
      Necrosis, Focal                                  1 (2%)                    2 (3%)                    3 (5%)                   
      Epithelium, Mineralization                       1 (2%)                    1 (2%)                                             
   Tooth                                              (1)                       (1)                       (1)                       
      Dysplasia                                        1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                 (1)                       
      Inflammation                                                                                         1 (100%)                 
      Mineralization                                   1 (100%)                                                                     
   Heart                                              (58)                      (58)                      (58)                      
      Cardiomyopathy                                  37 (64%)                  37 (64%)                  36 (62%)                  
      Embolus                                          1 (2%)                                                                       
      Inflammation                                     2 (3%)                                                                       
      Mineralization                                   1 (2%)                                              1 (2%)                   
      Atrium, Thrombosis                               7 (12%)                   6 (10%)                   4 (7%)                   
      Valve, Thrombosis                                                                                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (57)                      (58)                      (58)                      
      Atrophy                                                                    1 (2%)                                             
      Degeneration, Cystic                             2 (4%)                    3 (5%)                    5 (9%)                   
      Hyperplasia, Diffuse                             1 (2%)                                                                       
      Hyperplasia, Focal                               3 (5%)                    2 (3%)                    2 (3%)                   
      Necrosis                                         2 (4%)                                              1 (2%)                   
      Vacuolization Cytoplasmic                       23 (40%)                   7 (12%)                  12 (21%)                  
   Adrenal Medulla                                    (58)                      (57)                      (58)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                     26 (45%)                  22 (39%)                  11 (19%)                  
      Bilateral, Thrombosis                                                                                1 (2%)                   
   Islets, Pancreatic                                 (58)                      (58)                      (58)                      
      Hyperplasia                                      1 (2%)                                              1 (2%)                   
   Parathyroid Gland                                  (55)                      (55)                      (56)                      
      Hyperplasia                                      8 (15%)                   6 (11%)                   1 (2%)                   
   Pituitary Gland                                    (58)                      (57)                      (58)                      
      Cyst                                                                                                 1 (2%)                   
      Pars Distalis, Angiectasis                       4 (7%)                    9 (16%)                   3 (5%)                   
      Pars Distalis, Cyst                              1 (2%)                    1 (2%)                    3 (5%)                   
      Pars Distalis, Hyperplasia                      17 (29%)                  12 (21%)                  13 (22%)                  
   Thyroid Gland                                      (57)                      (58)                      (58)                      
      C-Cell, Hyperplasia                              7 (12%)                   8 (14%)                   7 (12%)                  
      Follicle, Hyperplasia                            1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (39)                      (47)                      (48)                      
      Inflammation                                     1 (3%)                    3 (6%)                    1 (2%)                   
   Epididymis                                         (58)                      (58)                      (58)                      
      Granuloma Sperm                                                            3 (5%)                                             
      Inflammation                                                                                         1 (2%)                   
   Penis                                              (2)                                                 (1)                       
      Concretion                                       2 (100%)                                                                     
   Preputial Gland                                    (58)                      (58)                      (58)         (1)          
      Ectasia                                          2 (3%)                    1 (2%)                    2 (3%)       1 (100%)    
      Hyperplasia                                      3 (5%)                    1 (2%)                    1 (2%)                   
      Inflammation                                     2 (3%)                    6 (10%)                   4 (7%)                   
   Prostate                                           (58)                      (58)                      (58)                      
      Inflammation                                     2 (3%)                    3 (5%)                                             
   Seminal Vesicle                                    (57)                      (58)                      (57)                      
      Atrophy                                          1 (2%)                    2 (3%)                    2 (4%)                   
      Epithelium, Hyperplasia                                                                              1 (2%)                   
   Testes                                             (58)                      (58)                      (58)                      
      Germinal Epithelium, Degeneration                7 (12%)                  13 (22%)                  13 (22%)                  
      Interstitial Cell, Hyperplasia                  14 (24%)                  16 (28%)                  18 (31%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)                      (57)                      (58)                      
      Atrophy                                          4 (7%)                    3 (5%)                    2 (3%)                   
      Fibrosis                                         2 (3%)                                              1 (2%)                   
      Granuloma                                                                                            1 (2%)                   
      Inflammation, Focal, Granulomatous               1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                                                                            1 (2%)                   
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Myeloid Cell, Hyperplasia                        1 (2%)                    1 (2%)                    5 (9%)                   
   Lymph Node                                         (5)                       (16)                      (6)                       
      Iliac, Hyperplasia, Lymphoid                                               1 (6%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                                                    1 (17%)                  
      Renal, Angiectasis                               1 (20%)                                                                      
      Renal, Pigmentation                                                        1 (6%)                                             
   Lymph Node, Bronchial                              (57)         (4)          (56)         (5)          (57)         (5)          
      Angiectasis                                      1 (2%)                                                                       
      Ectasia                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                            5 (9%)                   34 (61%)      4 (80%)     38 (67%)      5 (100%)    
      Hyperplasia, Macrophage                          1 (2%)                   18 (32%)                  32 (56%)                  
      Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                    1 (2%)                   
   Lymph Node, Mandibular                             (55)                      (56)                      (54)                      
      Hyperplasia, Lymphoid                            4 (7%)                    7 (13%)                   3 (6%)                   
      Hyperplasia, Plasma Cell                         6 (11%)                  10 (18%)                   4 (7%)                   
      Inflammation                                     2 (4%)                                                                       
   Lymph Node, Mesenteric                             (58)                      (58)                      (58)                      
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                            5 (9%)                   11 (19%)                   6 (10%)                  
      Hyperplasia, Macrophage                                                                              1 (2%)                   
      Inflammation                                     1 (2%)                                                                       
   Lymph Node, Mediastinal                            (53)         (5)          (54)         (5)          (53)         (5)          
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                   15 (28%)      5 (100%)     9 (17%)      3 (60%)     
      Hyperplasia, Macrophage                                                    2 (4%)                                             
      Inflammation                                     1 (2%)                                                                       
   Spleen                                             (58)                      (58)                      (58)                      
      Atrophy                                          3 (5%)                    2 (3%)                    1 (2%)                   
      Fibrosis                                        10 (17%)                  13 (22%)                  12 (21%)                  
      Hematopoietic Cell Proliferation                 2 (3%)                                                                       
      Hemorrhage                                                                                           1 (2%)                   
      Hyperplasia, Lymphoid                                                      4 (7%)                    1 (2%)                   
      Infarct                                                                    2 (3%)                                             
      Pigmentation, Hemosiderin                                                  2 (3%)                    3 (5%)                   
   Thymus                                             (55)                      (53)                      (53)                      
      Degeneration                                    17 (31%)                   3 (6%)                   10 (19%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)                      (53)                      (48)                      
      Hyperplasia, Cystic                              8 (15%)                   2 (4%)                    2 (4%)                   
   Skin                                               (58)                      (58)                      (58)                      
      Cyst Epithelial Inclusion                        2 (3%)                    1 (2%)                    1 (2%)                   
      Conjunctiva, Inflammation                        1 (2%)                                                                       
      Dermis, Inflammation                             1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation                                                                    1 (2%)                   
      Tail, Hyperkeratosis                                                       1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                      (57)                      (58)                      
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Hyperostosis                                     1 (2%)                    4 (7%)                    1 (2%)                   
      Mandible, Necrosis                                                                                   1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)                      (58)                      (58)                      
      Compression                                      1 (2%)                                                                       
      Cyst                                                                                                 1 (2%)                   
      Embolus                                          1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Cerebrum, Atrophy, Focal                                                                             1 (2%)                   
      Cerebrum, Compression                            6 (10%)                   4 (7%)                    4 (7%)                   
      Gray Matter, Necrosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (54)                      (57)                      (57)                      
      Hyperplasia                                      4 (7%)                                                                       
      Inflammation                                     3 (6%)                    2 (4%)                    2 (4%)                   
   Lung                                               (58)         (5)          (58)         (5)          (58)         (5)          
      Embolus                                          1 (2%)                                                                       
      Emphysema                                                                  1 (2%)                    1 (2%)                   
      Fibrosis                                         2 (3%)                   48 (83%)                  40 (69%)                  
      Hemorrhage, Acute                                7 (12%)                   1 (2%)                                             
      Inflammation, Chronic Active                     9 (16%)      1 (20%)     58 (100%)     5 (100%)    56 (97%)      5 (100%)    
      Metaplasia, Osseous                              2 (3%)                    2 (3%)       1 (20%)      2 (3%)                   
      Metaplasia, Squamous                                                       2 (3%)                                             
      Mineralization                                   1 (2%)                                              1 (2%)                   
      Alveolar Epithelium, Hyperplasia, Focal          2 (3%)                    6 (10%)                  11 (19%)                  
      Alveolus, Emphysema                                                                                  1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolus, Hyperplasia, Macrophage               10 (17%)                  53 (91%)      5 (100%)    57 (98%)      5 (100%)    
      Alveolus, Proteinosis                            1 (2%)                   41 (71%)      3 (60%)     56 (97%)      5 (100%)    
      Bronchus, Hyperplasia, Lymphoid                                           10 (17%)      1 (20%)     14 (24%)      4 (80%)     
      Interstitium, Infiltration Cellular             19 (33%)      3 (60%)     35 (60%)      5 (100%)    43 (74%)      5 (100%)    
   Nose                                               (58)         (5)          (58)         (5)          (57)         (5)          
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                    13 (22%)                  12 (21%)                  18 (32%)      3 (60%)     
      Thrombosis                                       3 (5%)                    3 (5%)                    4 (7%)                   
      Nasolacrimal Duct, Inflammation                                                                      3 (5%)                   
      Olfactory Epithelium, Atrophy                    2 (3%)                    1 (2%)                    9 (16%)      1 (20%)     
      Olfactory Epithelium, Mineralization, Focal      1 (2%)                                              3 (5%)                   
      Respiratory Epithelium, Hyperplasia                                                                               1 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)                       (4)                       (3)                       
      Cataract                                         1 (25%)                   2 (50%)                                            
      Inflammation                                     1 (25%)                                                                      
      Phthisis Bulbi                                   1 (25%)                                                                      
      Anterior Chamber, Hemorrhage, Chronic                                      1 (25%)                                            
      Iris, Inflammation                                                         1 (25%)                                            
      Retina, Degeneration                                                       3 (75%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (5)          (58)         (5)          (58)         (5)          
      Cyst                                             1 (2%)                    2 (3%)                    2 (3%)                   
      Embolus                                          1 (2%)                                                                       
      Hydronephrosis                                                                                       1 (2%)                   
      Infarct                                          1 (2%)                                              1 (2%)                   
      Inflammation                                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                                              1 (2%)                   
      Nephropathy                                     56 (98%)                  58 (100%)                 58 (100%)                 
      Cortex, Infarct                                                                                      2 (3%)                   
      Papilla, Necrosis                                                                                    1 (2%)                   
      Renal Tubule, Pigmentation                      20 (35%)                  35 (60%)                  35 (60%)                  
   Urethra                                                                      (1)                                                 
      Calculus Micro Observation Only                                            1 (100%)                                           
   Urinary Bladder                                    (58)         (3)          (58)         (4)          (58)         (5)          
      Calculus Gross Observation                       4 (7%)                    2 (3%)                                             
      Calculus Micro Observation Only                  5 (9%)       2 (67%)      3 (5%)       4 (100%)     3 (5%)       5 (100%)    
      Congestion                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05107-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation                                                                                         3 (5%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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