National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1875

TDMS Study 05107-05 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         NICKEL SUBSULFIDE


NTP Experiment-Test: 05107-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  09/30/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                  2            5            2            5            2            5           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24                        27                        23                        
    Natural Death                                      4                         1                         1                        
    Accidently Killed                                                                                      1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                        25                        28                        
  Animals Examined Microscopically                    58            5           58            5           58            5           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (58)                      (58)                      (58)         (1)          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Mesentery                                          (1)                                                 (2)                       
      Histiocytic Sarcoma                                                                                  1 (50%)                  
   Pancreas                                           (58)                      (57)                      (58)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Stomach, Forestomach                               (58)                      (58)                      (58)                      
   Stomach, Glandular                                 (58)                      (58)                      (58)                      
   Tooth                                              (1)                       (1)                                                 
      Gingiva, Squamous Cell Carcinoma                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)                      (58)                      (58)                      
      Schwannoma NOS                                   1 (2%)                    2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)                      (58)                      (58)                      
   Adrenal Medulla                                    (58)                      (56)                      (58)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Pheochromocytoma Malignant                       1 (2%)                                              1 (2%)                   
      Pheochromocytoma Benign                          2 (3%)                    6 (11%)                  12 (21%)                  
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                   24 (41%)                  
   Islets, Pancreatic                                 (58)                      (58)                      (58)                      
      Adenoma                                                                    1 (2%)                    1 (2%)                   
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (52)                      (55)                      (54)                      
                                                             Page   2                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (57)                      (58)                      (58)                      
      Pars Distalis, Adenoma                          24 (42%)                  31 (53%)                  17 (29%)                  
   Thyroid Gland                                      (56)                      (58)                      (57)                      
      C-Cell, Adenoma                                  3 (5%)                    4 (7%)                    4 (7%)                   
      C-Cell, Carcinoma                                                          3 (5%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (2)                       (1)                       
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Lung                                                       1 (50%)                                            
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic, Lung                                                                                1 (100%)                 
      Thoracic, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Lung                                                       1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)                      (57)                      (57)                      
      Adenoma                                                                    2 (4%)                    1 (2%)                   
      Carcinoma                                        2 (4%)                    3 (5%)                    3 (5%)                   
   Ovary                                              (58)         (1)          (58)         (1)          (58)         (1)          
      Cystadenoma                                                                                          1 (2%)                   
      Granulosa Cell Tumor Benign                      2 (3%)                                                                       
      Granulosa-Theca Tumor Benign                                               1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Uterus                                             (58)                      (58)                      (58)                      
      Adenoma                                                                    1 (2%)                                             
      Polyp Stromal                                    2 (3%)                    1 (2%)                    3 (5%)                   
      Sarcoma Stromal                                                                                      1 (2%)                   
   Vagina                                                                       (1)                       (2)                       
      Polyp                                                                                                1 (50%)                  
      Schwannoma Malignant                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)                      (58)                      (58)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Lymph Node                                         (5)                       (3)                       (10)                      
      Iliac, Histiocytic Sarcoma                                                                           1 (10%)                  
      Renal, Histiocytic Sarcoma                                                                           1 (10%)                  
   Lymph Node, Bronchial                              (55)         (5)          (54)         (5)          (55)         (5)          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
                                                             Page   3                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (49)                      (53)                      (56)                      
   Lymph Node, Mesenteric                             (57)                      (58)                      (57)                      
   Lymph Node, Mediastinal                            (51)         (5)          (55)         (4)          (52)         (5)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Spleen                                             (58)                      (58)                      (58)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Thymus                                             (54)                      (56)                      (55)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)                      (58)                      (58)                      
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)                    3 (5%)                                             
      Fibroadenoma                                    22 (38%)                  11 (19%)                  10 (17%)                  
   Skin                                               (58)                      (58)                      (58)                      
      Fibrosarcoma                                                               1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Keratoacanthoma                                                                                      1 (2%)                   
      Pinna, Fibrosarcoma                              1 (2%)                                              1 (2%)                   
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                      (58)                      (58)                      
      Squamous Cell Carcinoma, Metastatic, Tooth                                 1 (2%)                                             
   Skeletal Muscle                                                              (1)                                                 
      Squamous Cell Carcinoma, Metastatic, Tooth                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)                      (58)                      (58)                      
      Astrocytoma NOS                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (5)          (58)         (5)          (58)         (5)          
      Adenoma                                          1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    5 (9%)                    5 (9%)                   
      Alveolar/Bronchiolar Carcinoma                                                                       3 (5%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
                                                             Page   4                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Squamous Cell Carcinoma                                                    1 (2%)                                             
   Nose                                               (58)         (5)          (58)         (5)          (57)         (5)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (5)          (58)         (5)          (58)         (5)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Nephroblastoma                                   1 (2%)                                                                       
   Urinary Bladder                                    (58)                      (58)                      (58)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(5)         *(58)        *(5)         *(58)        *(5)          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Leukemia Mononuclear                            19 (33%)                  18 (31%)                  22 (38%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49                      53                      52                           
     Total Primary Neoplasms                           85                     102                     113                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37                      46                      48                           
     Total Benign Neoplasms                            58                      65                      80                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25                      31                      29                           
     Total Malignant Neoplasms                         26                      34                      33                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      2                       1                           
     Total Metastatic Neoplasm                                                  4                       3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       3                                                   
     Total Uncertain Neoplasms                          1                       3                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                  5            5            5            5            5            5           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                35                        28                        33                        
    Natural Death                                      5                         4                         2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                13                        21                        18                        
  Animals Examined Microscopically                    58            5           58            5           58            5           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (56)                      (56)                      (58)                      
   Intestine Large, Rectum                            (51)                      (50)                      (57)                      
      Fibrosarcoma, Metastatic, Testes                                                                     1 (2%)                   
   Intestine Small, Duodenum                          (57)                      (57)                      (58)                      
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (56)                      (56)                      (57)                      
   Intestine Small, Ileum                             (56)                      (56)                      (57)                      
   Liver                                              (58)                      (58)                      (58)                      
      Hepatocellular Adenoma                           4 (7%)                    1 (2%)                    3 (5%)                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (1)                       (1)                       (1)                       
   Pancreas                                           (58)                      (58)                      (58)                      
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pharynx                                                                                                (1)                       
      Squamous Cell Papilloma                                                                              1 (100%)                 
   Salivary Glands                                    (58)                      (57)                      (58)                      
   Stomach, Forestomach                               (58)                      (58)                      (58)                      
      Squamous Cell Papilloma                                                                              1 (2%)                   
   Stomach, Glandular                                 (58)                      (58)                      (58)                      
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Tooth                                              (1)                       (1)                       (1)                       
      Gingiva, Squamous Cell Carcinoma                                                                     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)                      (58)                      (58)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (57)                      (58)                      (58)                      
   Adrenal Medulla                                    (58)                      (57)                      (58)                      
      Pheochromocytoma Malignant                                                 2 (4%)                    6 (10%)                  
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                         12 (21%)                  23 (40%)                  14 (24%)                  
      Bilateral, Pheochromocytoma Malignant                                                                5 (9%)                   
      Bilateral, Pheochromocytoma Benign               1 (2%)                    7 (12%)                  23 (40%)                  
   Islets, Pancreatic                                 (58)                      (58)                      (58)                      
      Adenoma                                          2 (3%)                    4 (7%)                    4 (7%)                   
      Carcinoma                                                                  1 (2%)                    2 (3%)                   
   Parathyroid Gland                                  (55)                      (55)                      (56)                      
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (58)                      (57)                      (58)                      
      Pars Distalis, Adenoma                          20 (34%)                  17 (30%)                  17 (29%)                  
   Thyroid Gland                                      (57)                      (58)                      (58)                      
      C-Cell, Adenoma                                  4 (7%)                    2 (3%)                    9 (16%)                  
      C-Cell, Carcinoma                                2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                       (1)                       (1)                       
      Abdominal, Fibrosarcoma                                                                              1 (100%)                 
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (100%)                                           
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic, Lung                                                      1 (100%)                                           
      Thoracic, Fibrosarcoma                           1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (58)                      (58)                      (58)         (1)          
      Adenoma                                          1 (2%)                    2 (3%)                                             
      Carcinoma                                        2 (3%)                                                                       
   Prostate                                           (58)                      (58)                      (58)                      
   Seminal Vesicle                                    (57)                      (58)                      (57)                      
   Testes                                             (58)                      (58)                      (58)                      
      Bilateral, Interstitial Cell, Adenoma           28 (48%)                  30 (52%)                  15 (26%)                  
      Interstitial Cell, Adenoma                      15 (26%)                  16 (28%)                  22 (38%)                  
      Tunic, Fibrosarcoma                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)                      (57)                      (58)                      
   Lymph Node                                         (5)                       (16)                      (6)                       
      Iliac, Fibrosarcoma, Metastatic, Testes                                                              1 (17%)                  
   Lymph Node, Bronchial                              (57)         (4)          (56)         (5)          (57)         (5)          
   Lymph Node, Mandibular                             (55)                      (56)                      (54)                      
   Lymph Node, Mesenteric                             (58)                      (58)                      (58)                      
   Lymph Node, Mediastinal                            (53)         (5)          (54)         (5)          (53)         (5)          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (58)                      (58)                      (58)                      
   Thymus                                             (55)                      (53)                      (53)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)                      (53)                      (48)                      
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                                               1 (2%)                                             
   Skin                                               (58)                      (58)                      (58)                      
      Basal Cell Adenoma                                                                                   1 (2%)                   
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Carcinoma, Metastatic, Preputial Gland           1 (2%)                                                                       
      Fibroma                                          2 (3%)                    2 (3%)                    3 (5%)                   
      Keratoacanthoma                                  4 (7%)                    4 (7%)                    1 (2%)                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Nose, Squamous Cell Papilloma                                                                        1 (2%)                   
      Pinna, Keratoacanthoma                           1 (2%)                                                                       
      Pinna, Squamous Cell Papilloma                   1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)                                              1 (2%)                   
      Tail, Fibroma                                    1 (2%)                                                                       
      Tail, Squamous Cell Papilloma                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                      (57)                      (58)                      
      Cranium, Osteosarcoma                            1 (2%)                                                                       
      Maxilla, Osteosarcoma                                                                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)                      (58)                      (58)                      
      Astrocytoma NOS                                                                                      1 (2%)                   
      Oligodendroglioma NOS                                                      1 (2%)                                             
   Spinal Cord                                        (1)                       (1)                                                 
      Astrocytoma Benign                               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (5)          (58)         (5)          (58)         (5)          
      Alveolar/Bronchiolar Adenoma                                               3 (5%)                    5 (9%)                   
      Alveolar/Bronchiolar Adenoma, Multiple                                                               1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                                             3 (5%)                    7 (12%)                  
      Carcinoma, Metastatic, Preputial Gland           1 (2%)                                                                       
      Chordoma, Metastatic, Tissue NOS                                                                     1 (2%)                   
      Fibrosarcoma, Metastatic, Testes                                                                     1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                              1 (2%)                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                                  1 (2%)                   
   Nose                                               (58)         (5)          (58)         (5)          (57)         (5)          
   Trachea                                            (58)                      (58)                      (57)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (5)          (58)         (5)          (58)         (5)          
   Urinary Bladder                                    (58)         (3)          (58)         (4)          (58)         (5)          
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 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(5)         *(58)        *(5)         *(58)        *(5)          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            28 (48%)                  32 (55%)                  36 (62%)                  
      Mesothelioma NOS                                 1 (2%)                    1 (2%)                                             
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05107-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:11:47  
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         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.15         0.15         1.0          1.0             
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            56                      53                      56                           
     Total Primary Neoplasms                          141                     158                     183                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 53                      53                      52                           
     Total Benign Neoplasms                           103                     115                     122                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33                      37                      46                           
     Total Malignant Neoplasms                         37                      41                      60                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2                       4                           
     Total Metastatic Neoplasm                          3                       4                       6                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       2                       1                           
     Total Uncertain Neoplasms                          9                       2                       1                           
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.