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TDMS Study 05107-05 Pathology Tables

NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  09/30/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|             
                                           | 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +     A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     A  +  +  +  +  +|             
      Inflammation                         |                         2                                                |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     A  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X        X  X  X  X  X        X  X  X  X  X        X  X  X  X  X|             
      Degeneration, Cystic                 |                                                                      1   |             
      Degeneration, Fatty                  |       2                    2  2     2  1           2                     |             
      Eosinophilic Focus                   |                                                 X                        |             
      Hepatodiaphragmatic Nodule           |       X  X                                X  X                           |             
      Inflammation, Focal, Granulomatous   |    1                             1        2  1  2           1     1  1   |             
      Inflammation, Granulomatous          |          1  1                                                            |             
      Mixed Cell Focus                     |                         X                                                |             
      Pigmentation, Hemosiderin            |                                                 3              3         |             
      Bile Duct, Hyperplasia               |       2        2        2           1        1                 2         |             
      Biliary Tract, Hyperplasia           |                                                                      1   |             
      Centrilobular, Atrophy               |                2        1           1                          3         |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Fat, Necrosis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |    2  3                             1  2     2  4                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                 3                        |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                4         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cardiomyopathy                       | 1                       1     1                 3  2     1        1     1|             
      Atrium, Thrombosis                   |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|             
                                           | 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Degeneration, Cystic                 |       2        1                       3           2        3  1         |             
      Hyperplasia, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +     M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     I  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    4  3                       3        4  2                 3  3     3   |             
      Pars Distalis, Cyst                  |       X        X  X                                                      |             
      Pars Distalis, Hyperplasia           | 4  2              3     4                                               2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +     M  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1  3              1           1     1  1              1        1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                        3           2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Endometrium, Hyperplasia, Cystic     |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                 4              2         |             
      Inflammation, Focal, Granulomatous   |    1                                                           3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                    +  +                     |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  I  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  2     2                             1   |             
      Hyperplasia, Macrophage              |          1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  I  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +     +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|             
                                           | 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Macrophage              |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  +  +  +  +  M  +  +  I  +  +  +  +     +  I  +  M  +  +|             
      Hyperplasia, Macrophage              |          1                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Fibrosis                             |                         3                                                |             
      Hemorrhage                           |                            4                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            | 3                                                  3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +     +  +  +  +  +  +|             
      Degeneration                         |                3        3                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2  2        2                 1           1  2              2  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Tail, Hyperkeratosis                 |                                                                          |             
      Tail, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperostosis                         |                               X                 X                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Cerebrum, Compression                |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  I  +  +  +|             
      Hyperplasia, Squamous                |                3                                                         |             
      Inflammation                         |                2           1                                             |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage, Acute                    |          1           1                                                   |             
      Inflammation, Chronic Active         | 1                                                  2                    1|             
      Metaplasia, Osseous                  |                                                             1            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Hyperplasia, Macrophage    |    1        1                 1           1        1        1           1|             
      Alveolus, Proteinosis                |    1                                               1                     |             
      Interstitium, Infiltration Cellular  | 1  1                          1  1     1     1              1        1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|             
                                           | 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3     2  1                                                            |             
      Thrombosis                           |                                                 1                        |             
      Nasolacrimal Duct, Inflammation      |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Cataract                             |                         4                                                |             
      Retina, Degeneration                 |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 3  1  4     1  1  1     4     4  1  2  4  1  1  3  3        1  2  2  2  1|             
      Renal Tubule, Pigmentation           | 3     4        3        2     2  1  3  3  3     3           3  3  1  3  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|             
                                           | 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  I  +  +  M     +  M  I  +  +  +  +  +  I  +  M  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |          X                          X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              2           3              3|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X     X  X  X  X  X  X     X  X     X  X   |             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  |                3     1     3              1  1  1     2              3  3|             
      Eosinophilic Focus                   |                                  X     X                                 |             
      Hepatodiaphragmatic Nodule           |             X        X                                                   |             
      Inflammation, Focal, Granulomatous   | 1     1  1  1                    3           1  1  1  3  2  1     1      |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                       X                  |             
      Pigmentation, Hemosiderin            |                                                                      2   |             
      Bile Duct, Hyperplasia               | 1     1        1           1  1        2           1     2     3     2   |             
      Biliary Tract, Hyperplasia           |                                                                          |             
      Centrilobular, Atrophy               |                1     1                 3                       3     2   |             
      Hepatocyte, Hyperplasia              | 3                                3                 2  3                  |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2        2     2                 2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                       2                  |             
      Ulcer                                |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
      Peridontal Tissue, Inflammation      | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1              1     1     1  1  1  1  1  1  1  1        1  1  1         |             
      Atrium, Thrombosis                   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|             
                                           | 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2        1                             2                    4            |             
      Hyperplasia, Focal                   |                            1                                             |             
      Vacuolization Cytoplasmic            |                2                 3                                   3   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                    1  1        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  4     2  3           2        4     3  4        4        3            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    4  2     3              2           4                       2     4   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     1  1                                         1     1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                             4  2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                             X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3                                               2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      2   |             
      Fibrosis                             |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                   1      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                +         |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2                    2     2  2                       1  2  3     1   |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  I  +  +  +     I  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                       1     2                                          |             
      Hyperplasia, Plasma Cell             |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                               2        1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|             
                                           | 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               3                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                  2                 2  2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                         2                             2     3            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                2         |             
      Inflammation                         |                                                                2         |             
      Tail, Hyperkeratosis                 |                                                                3         |             
      Tail, Inflammation                   |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                     X                 X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                       2                  |             
      Cerebrum, Compression                |                                  X                 X  X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Chronic Active         | 2              1                       1                                 |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           3                              |             
      Alveolus, Hyperplasia, Macrophage    |       1                       1                                          |             
      Alveolus, Proteinosis                |                                                                          |             
      Interstitium, Infiltration Cellular  | 1  1  1  1  1           1     1  1  1        1     1     1  1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|             
                                           | 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1  1           1                    3              1            |             
      Thrombosis                           |                1                                                         |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                        3                                 |             
      Retina, Degeneration                 |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                X         |             
      Nephropathy                          | 3  1  2  3  1  3     3  4  1  4  4  3  4  3  3  3  2  4  4  4  2  1  2  3|             
      Renal Tubule, Pigmentation           | 2  2  3  4  3  3     3  3  4  2     2  3  2  3  3  3  2  4  3  3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 4| 7| 4| 4| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3|                                            |            |
                                           | 9| 9| 4| 9| 1| 7| 1| 9| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 7| 9| 0| 1| 3| 4| 5| 6| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +                                             |  54        |
      Inflammation                         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +                                             |  55        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     | X  X  X     X     X  X  X  X                                             |     47     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Degeneration, Fatty                  |             2                                                            |     16  1.9|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |             X                                                            |      7     |
      Inflammation, Focal, Granulomatous   |    2  1                 1  1                                             |     24  1.3|
      Inflammation, Granulomatous          |          1           1                                                   |      4  1.0|
      Mixed Cell Focus                     |                   X                                                      |      3     |
      Pigmentation, Hemosiderin            |                                                                          |      3  2.7|
      Bile Duct, Hyperplasia               | 1                 1                                                      |     18  1.5|
      Biliary Tract, Hyperplasia           |                                                                          |      1  1.0|
      Centrilobular, Atrophy               |                                                                          |      9  1.9|
      Hepatocyte, Hyperplasia              |                                                                          |      4  2.8|
      Hepatocyte, Necrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |     10  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Squamous                |             3                                                            |      2  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |             4                                                            |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 4| 7| 4| 4| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3|                                            |            |
                                           | 9| 9| 4| 9| 1| 7| 1| 9| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 7| 9| 0| 1| 3| 4| 5| 6| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       | 1           1     1                                                      |     25  1.1|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration, Cystic                 |                            2                                             |     11  2.1|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |             3                                                            |      4  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Pars Distalis, Angiectasis           | 2                 2        3                                             |     21  3.0|
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hyperplasia           |                         2                                                |     13  2.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      C-Cell, Hyperplasia                  |             1     1                                                      |     16  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Cystic                  |    3        3                                                            |      6  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 | X              X                                                         |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |             2                                                            |      2  2.0|
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Focal, Granulomatous   |    1                                                                     |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 4| 7| 4| 4| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3|                                            |            |
                                           | 9| 9| 4| 9| 1| 7| 1| 9| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 7| 9| 0| 1| 3| 4| 5| 6| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   5        |
      Renal, Hyperplasia, Lymphoid         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hyperplasia, Lymphoid                |                                                                          |     11  1.8|
      Hyperplasia, Macrophage              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Hyperplasia, Plasma Cell             |                            2                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Hyperplasia, Macrophage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +                                             |  51        |
      Hyperplasia, Macrophage              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
      Pigmentation, Hemosiderin            |                         2  2                                             |      7  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Degeneration                         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Cystic                  |                                                                          |     11  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Tail, Hyperkeratosis                 |                                                                          |      1  3.0|
      Tail, Inflammation                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperostosis                         |       X                                                                  |      5     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |       X                                                                  |      1     |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 4| 7| 4| 4| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3|                                            |            |
                                           | 9| 9| 4| 9| 1| 7| 1| 9| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 7| 9| 0| 1| 3| 4| 5| 6| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cerebrum, Compression                |                            X                                             |      5     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage, Acute                    |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |       1                                                                  |      7  1.3|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   1                                                      |      2  2.0|
      Alveolus, Hyperplasia, Macrophage    |                                                                          |      9  1.0|
      Alveolus, Proteinosis                |                                                                          |      2  1.0|
      Interstitium, Infiltration Cellular  |    2  2     1     1     1  1                                             |     28  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic Active         |          1                                                               |      9  1.6|
      Thrombosis                           |                                                                          |      2  1.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.5|
      Retina, Degeneration                 |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 3  3  1     4  2  4     1  4                                             |     52  2.5|
      Renal Tubule, Pigmentation           | 4  3           2  2        3                                             |     40  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 7| 8| 0| 0| 0| 1| 2| 3| 3| 3|                                            |      L     |
    LUNG TOX                               | 9| 8| 4| 6| 8| 2| 8| 2| 7| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                      +                                                   |   1        |
      Cyst                                 |                      X                                                   |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     +  +     +  +                                                   |   5        |
      Hyperplasia, Lymphoid                |          1  1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +     +  +     +  +                                                   |   5        |
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +     +  +                                                   |   5        |
      Metaplasia, Osseous                  |                      1                                                   |      1  1.0|
      Interstitium, Infiltration Cellular  |    1                 1                                                   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +  +     +  +                                                   |   5        |
      Inflammation, Chronic Active         |          1                                                               |      1  1.0|
      Olfactory Epithelium, Erosion, Focal |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 7| 8| 0| 0| 0| 1| 2| 3| 3| 3|                                            |      L     |
    LUNG TOX                               | 9| 8| 4| 6| 8| 2| 8| 2| 7| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +     +  +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|             
                                           | 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/M3                                  | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  M  +  M  +  +  +  +  +  I  +  +  +  +  M  +  M  +  +  +  +  +  M  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    3              2                    3     2                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X     X  X  X     X  X  X        X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |          1                                                               |             
      Degeneration, Fatty                  | 1  1                                         4  3     3                  |             
      Eosinophilic Focus                   |                                                                         X|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                  X        X                              |             
      Inflammation, Focal, Granulomatous   | 1           2  1     1     2              1              1  1     1      |             
      Inflammation, Granulomatous          |       1                                                                  |             
      Mixed Cell Focus                     |                                                       X                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Bile Duct, Hyperplasia               |    1                    1              1     2     2     1  1  1         |             
      Centrilobular, Atrophy               |                                  1                                       |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                            2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |    2                                         3        4                  |             
      Ulcer                                |                                                       4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1                          2  1  2  1     1              1  1     1     1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |          3  2        4                             2           3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|             
                                           | 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/M3                                  | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            |                3                             3                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4           2        1        3                          2  1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           | 2                 2     2              2  2        2                     |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                        3        3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1     1  1                 1     1                          1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                   3                 4                                3   |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Hyperplasia, Lymphoid                | 4  2     1  2  2  2  2     2  3     2  2  2     1     2     3  1  1  2  2|             
      Hyperplasia, Macrophage              | 1  1        1  2  1           2     1     1                 1        1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              4  2                        |             
      Hyperplasia, Plasma Cell             |             2                             2           3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|             
                                           | 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/M3                                  | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2        2                    2                       2     2     2   |             
      Hyperplasia, Macrophage              |    1        1                                            1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |    2           2  3  2                                2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Cystic                  |    2                 1                       3        2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Tail, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         | X                       X                    X                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                2                                                         |             
      Cerebrum, Compression                | X              X     X                                X                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration, Secondary Wallerian    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 1  2     2  2  2  2  2     1  2  2  1  1  1  2  2  3  2  1  1  1  2  2  2|             
      Hemorrhage, Acute                    |       2                                                                  |             
      Inflammation, Chronic Active         | 3  3  3  3  3  2  3  2     3  2  2  2  2  2  2  2  3  3  2  3  2  3  4  3|             
      Metaplasia, Osseous                  |             1                                                            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2  1              2        3              2        2                     |             
      Alveolus, Hyperplasia, Macrophage    | 3  3  2  3  3  2  3  2     3  3  2  3  2  3     1  3  2  3  3  3  3  3  3|             
      Alveolus, Proteinosis                | 3  3  2  2  3  1  1  2     2  2  1  2  1  1        2  2  3  1  3  2  1  1|             
      Bronchus, Hyperplasia, Lymphoid      | 1  2        2     1                 2     2                 1     2  2   |             
      Interstitium, Infiltration Cellular  | 1  3  1  2  2     2        2  2     1  2  1        1  2  1  2  2  1  2  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|             
                                           | 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/M3                                  | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          2           1                 1        3                        |             
      Nasolacrimal Duct, Hyperplasia       |       2                                                                  |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Cataract                             |                                                                   3      |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 4  3  1  2  4  3  2  2  2  2  2  1  2  1  2  1  2  4  2  3  4  4  1  1  1|             
      Renal Tubule, Pigmentation           | 2  2        2  3  4  1  4  2        1     2  2  4  4     3  1  4  1  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|             
                                           | 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  M  +  +  A  +  +  M  +  +     +  M  +  +  +  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X  X     X  X        X     X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |          X                                                               |             
      Degeneration, Cystic                 |                   1                             1                        |             
      Degeneration, Fatty                  |             1                                   3        2  2           1|             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hepatodiaphragmatic Nodule           |                      X                          X                        |             
      Inflammation, Focal, Granulomatous   |          1                          1  1        1  2  1  1     1     1  1|             
      Inflammation, Granulomatous          |                      1                                                   |             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Bile Duct, Hyperplasia               |                   1                       1                 2            |             
      Centrilobular, Atrophy               |       3     2                             3                              |             
      Hepatocyte, Hyperplasia              |                                                             3            |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |    2                                                                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                        1                 1  1  1         |             
      Atrium, Thrombosis                   |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2                                               2     3        2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|             
                                           | 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                             3            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +  +  +  +  +  I  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4              1                                      1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Pars Distalis, Angiectasis           |                   3           2                          3        2      |             
      Pars Distalis, Cyst                  |                                        X           X           X         |             
      Pars Distalis, Hyperplasia           |          4                                                     2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2           3                 2           1     3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                      +                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                              4        3                  |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X        X               |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |                                                          2               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |    2                                                                     |             
      Myeloid Cell, Hyperplasia            |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                          +                              |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                      1                                                   |             
      Hyperplasia, Lymphoid                |    2  2  2  2     2  2              1  2     1     2  2     1  2     2  2|             
      Hyperplasia, Macrophage              |       1  1        1        1           1           1                 3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  M  M  +     +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2           2                             2                        |             
      Hyperplasia, Plasma Cell             |          2                                      2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                     1  1        1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|             
                                           | 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |          2                          1        1        2                  |             
      Hyperplasia, Macrophage              |          1           1                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |    2                                                        3            |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Pigmentation, Hemosiderin            |                   3                                      2  2           3|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2                                                                  |             
      Hyperplasia, Cystic                  |                   2                       2     2                       3|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |       4                                                                  |             
      Tail, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Cerebrum, Compression                |       X                                                  X  X           X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration, Secondary Wallerian    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    1  1     1  1  3           1     1  2     1  2  2  2  2  2  2  1  2  2|             
      Hemorrhage, Acute                    |                         1  1                                             |             
      Inflammation, Chronic Active         |    2  2  2  3  2  2  3  2  2  3     2  3     2  2  3  3  2  2  3  2  3  2|             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                       2           2  2   |             
      Alveolus, Hyperplasia, Macrophage    |    3  2  3  2  3  2  2  3  3  3     2  1  2  2  2  2  2  2  3  2  2  3  2|             
      Alveolus, Proteinosis                |    2  2  4  2  2  2  1  2  2  2     1  2     3  2  1  1  2  2  2  2  3  3|             
      Bronchus, Hyperplasia, Lymphoid      |          1                          1                             1  1  1|             
      Interstitium, Infiltration Cellular  |          1  1     1     1  1  1     1        1     1  3  1  1  2  2  3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|             
                                           | 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1        3  1  1           1  1                    2            |             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
      Nasolacrimal Duct, Inflammation      |          2                                            2                  |             
      Olfactory Epithelium, Metaplasia     |                   3                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    2  1  2  1  1  2     2     2     4  2  1  4  2  4  3  3  2  2  4  1  3|             
      Renal Tubule, Pigmentation           |       2  2  2     3           2     1  2  3  3  2  2  3  2  3  4  2  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 4| 5| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3|                                            |            |
                                           | 1| 9| 8| 0| 6| 9| 4| 8| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  M  +  M                                             |  43        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Parasite Metazoan                    |                         X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X                                             |     49     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |    1                                                                     |      4  1.0|
      Degeneration, Fatty                  |       4  4                                                               |     12  2.4|
      Eosinophilic Focus                   |                         X                                                |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Focal, Granulomatous   |    1              1     1                                                |     22  1.1|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Pigmentation, Hemosiderin            |             1                                                            |      1  1.0|
      Bile Duct, Hyperplasia               | 1           1                                                            |     13  1.2|
      Centrilobular, Atrophy               |          3                                                               |      5  2.4|
      Hepatocyte, Hyperplasia              |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |                         2                                                |      4  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Squamous                |          3                                                               |      5  2.8|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       |                   1  1  1                                                |     17  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 4| 5| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3|                                            |            |
                                           | 1| 9| 8| 0| 6| 9| 4| 8| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration, Cystic                 |       4                    2                                             |     11  2.6|
      Vacuolization Cytoplasmic            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +                                             |  56        |
      Hyperplasia                          |       2           1                                                      |     11  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  55        |
      Hyperplasia                          |       2     2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Angiectasis           |                         3                                                |     11  2.3|
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hyperplasia           |                         4                                                |      5  3.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      C-Cell, Hyperplasia                  |                         1                                                |     12  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Cystic                  |                                                                          |      5  3.4|
      Inflammation                         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Erythroid Cell, Hyperplasia          |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   3        |
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 4| 5| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3|                                            |            |
                                           | 1| 9| 8| 0| 6| 9| 4| 8| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  M  +                                             |  54        |
      Hemorrhage, Acute                    |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |          1  2     2                                                      |     37  1.9|
      Hyperplasia, Macrophage              |                1                                                         |     18  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  I  +                                             |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.4|
      Hyperplasia, Plasma Cell             |                            3                                             |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Hyperplasia, Lymphoid                |                            3                                             |      5  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  I  +                                             |  55        |
      Hyperplasia, Lymphoid                |                            2                                             |     11  1.8|
      Hyperplasia, Macrophage              |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     | 3                                                                        |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            | 3  2                    2                                                |     12  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia, Cystic                  | 2     2  3        2  2     2                                             |     14  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ulcer                                |                                                                          |      1  4.0|
      Tail, Inflammation                   |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperostosis                         |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Cerebrum, Compression                | X                 X                                                      |     10     |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
      Degeneration, Secondary Wallerian    |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 4| 5| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3|                                            |            |
                                           | 1| 9| 8| 0| 6| 9| 4| 8| 5| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/M3                                  | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |          3                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             | 3  2  1  2  2     2  2  1  2                                             |     50  1.7|
      Hemorrhage, Acute                    |                                                                          |      3  1.3|
      Inflammation, Chronic Active         | 2  2  2  2  3  2  3  3  2  2                                             |     56  2.4|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 3                                                                        |     10  2.1|
      Alveolus, Hyperplasia, Macrophage    | 3  2  4  2  2  3  3  3  2  3                                             |     56  2.5|
      Alveolus, Proteinosis                | 3  3  2  1  3  2  3  2  3  2                                             |     54  2.0|
      Bronchus, Hyperplasia, Lymphoid      |             1                                                            |     15  1.4|
      Interstitium, Infiltration Cellular  |       1  1     1     2  1  1                                             |     40  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic Active         |                                                                          |     11  1.5|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      2  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   2        |
      Cataract                             |                         3                                                |      2  3.0|
      Retina, Degeneration                 |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Nephropathy                          | 4     4  1  1     2  4  1  4                                             |     54  2.3|
      Renal Tubule, Pigmentation           | 3     2  2  2     2  3     3                                             |     43  2.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 1| 1| 1| 1| 2| 5| 6| 6| 6| 7|                                            |      L     |
    LUNG TOX                               | 3| 4| 5| 7| 4| 9| 1| 4| 6| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +                                                                     |   1        |
      Cyst                                 |    X                                                                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +     +        +     +                                                |   5        |
      Hyperplasia, Lymphoid                | 1        1                                                               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +     +        +     M                                                |   4        |
      Hyperplasia, Lymphoid                | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +        +     +                                                |   5        |
      Inflammation, Chronic Active         | 1  1     1        1     2                                                |      5  1.2|
      Alveolus, Hyperplasia, Macrophage    | 2  2     2        2     2                                                |      5  2.0|
      Alveolus, Proteinosis                |          1              1                                                |      2  1.0|
      Bronchus, Hyperplasia, Lymphoid      |    1                                                                     |      1  1.0|
      Interstitium, Infiltration Cellular  | 1  1     1        1     1                                                |      5  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +        +     +                                                |   5        |
      Inflammation, Chronic Active         | 2                 1                                                      |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 1| 1| 1| 1| 2| 5| 6| 6| 6| 7|                                            |      L     |
    LUNG TOX                               | 3| 4| 5| 7| 4| 9| 1| 4| 6| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Erosion, Focal |    1              1                                                      |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +        +     +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|             
                                           | 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  M     +  M  +  +  +  +  +  M  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X  X  X  X  X        X        X  X  X  X        X     X     X|             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  |                      3              1  1           1  3                  |             
      Eosinophilic Focus                   |                         X                                            X   |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   1      |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Inflammation, Focal, Granulomatous   |                   1     1                          1        1  1  1  1   |             
      Inflammation, Granulomatous          |             2                    1                                       |             
      Mixed Cell Focus                     |                                  X                                       |             
      Pigmentation, Hemosiderin            |          2                                2           2                  |             
      Regeneration                         |                            1                                            4|             
      Bile Duct, Hyperplasia               |          2                 2                          1                 1|             
      Centrilobular, Atrophy               | 2        2                 2              3           2  2        2     1|             
      Hepatocyte, Atrophy                  |                                                    3                     |             
      Hepatocyte, Hyperplasia              |          2                                                               |             
      Vein, Thrombosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Necrosis                             |                2                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2        2     1                             2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                           2                       3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1     1              1           1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|             
                                           | 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 3                          2        2  2     2     3  2                  |             
      Hyperplasia, Focal                   | 3                                      2                             3   |             
      Hyperplasia                          |             3                                3                           |             
      Necrosis                             |    2                                                                     |             
      Vacuolization Cytoplasmic            |                         3                 3                          2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 2     3                 2              1              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          | 2        2                 2                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      3  3              2     3  4     2     4            |             
      Pars Distalis, Hyperplasia           | 3                                                                    3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3                                         2              1  1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                3           3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |          X        X                                                      |             
      Inflammation                         |                                                             3  2         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   3      |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                         4|             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +           +                          +                 +|             
      Pancreatic, Hyperplasia, Lymphoid    |                3                                                         |             
      Pancreatic, Hyperplasia, Macrophage  |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  3     2  1  3  2  2  2        2  4  4  3  2  3  3     2     3  4  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|             
                                           | 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Macrophage              |    1        1     2     1        1        1  1  1  1           1     1   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                3                                                         |             
      Hyperplasia, Macrophage              |    2                                                                    3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                3        3           4           3              2         |             
      Hyperplasia, Macrophage              |                         2                                      1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             2     3      |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          2        2        2           2  1        1  1  2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |    X                 X                                      X            |             
      Cranium, Hyperostosis                |                      3                                      2            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                     2              2                     |             
      Cerebrum, Compression                |                         X           X           X  X        X            |             
      Gray Matter, Necrosis                |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  I  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Inflammation                         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       1                  |             
      Emphysema                            |                                                                          |             
      Fibrosis                             |    1     1     2  1     2  3        1     1  2  2  1  1     2  2        2|             
      Hemorrhage, Acute                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|             
                                           | 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 1  2     2  1  2  3  2  2  4     1  1  2  2  3  2  1  2  2  3  2  2  1  2|             
      Metaplasia, Squamous                 |                                              3                           |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 1              2     1     3        1        1           1     2         |             
      Alveolus, Hyperplasia, Macrophage    | 3  3     2  3  3  3  2  3  3     3  3  3  3  3  2  2  2  4  3  3  3  2  1|             
      Alveolus, Proteinosis                | 4  4     4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  2  4  4  2  3  4|             
      Bronchus, Hyperplasia, Lymphoid      |             1     3        2        1  2     1  2              1         |             
      Interstitium, Infiltration Cellular  |    1        3  1  2     2  2     2     2  1  1  2  2        2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3     4  2     4        1              1                              |             
      Thrombosis                           |                                           1                              |             
      Nasolacrimal Duct, Inflammation      |                            3                                             |             
      Olfactory Epithelium, Atrophy        | 1        1              1  1        1                    1              1|             
      Olfactory Epithelium, Metaplasia     |          3                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Cataract                             |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                              +                           |             
      Metaplasia, Squamous                 |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 2  3     2     1  3  1  4  1     1  2  4  2  4  4  2  2     4  3  1  1  1|             
      Renal Tubule, Pigmentation           | 3  4     4     3  2     2              2  2  2  1  2  4  3  3  2        4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|             
                                           | 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
    MG/M3                                  | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X  X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2              2                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X     X  X  X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X|             
      Degeneration, Cystic                 |                                     1                                    |             
      Degeneration, Fatty                  | 1     2                          1     1     2                           |             
      Eosinophilic Focus                   |                                           X        X                     |             
      Granuloma                            |                   1                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Inflammation, Focal, Granulomatous   | 1                       2     1                 1                 1      |             
      Inflammation, Granulomatous          |                   1                                                  1  1|             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation, Hemosiderin            |                            2                 2           2               |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               | 1        1  2        1  1  1     1  1                                    |             
      Centrilobular, Atrophy               |                                  2           2           2               |             
      Hepatocyte, Atrophy                  |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Vein, Thrombosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                             3     2  2              2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                                                            |             
      Inflammation                         |             3                                                            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     2  1                          2  1     1  1  1     1            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|             
                                           | 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
    MG/M3                                  | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 4                          2     2  3     2              3        4      |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |          2                                                               |             
      Vacuolization Cytoplasmic            |                                              3                 3         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                    2        2                       3  1  2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         3     3        3     3  3  3        3  3         |             
      Pars Distalis, Hyperplasia           | 2  2           3        3     3              2     4     4  4     3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                 1     2                    1        3        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4                                                               |             
      Cyst                                 |       X                                                        X         |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |          4                                                               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  1                       3               |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                         +        +                  |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Hyperplasia, Macrophage  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3              2     2  3     2     2  2  3     2  3     2  2  3  3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|             
                                           | 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
    MG/M3                                  | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Macrophage              |       2        1  1  1  1     1  2  2  2  2        1        1  1  1     1|             
      Hyperplasia, Plasma Cell             |       3                          3                                       |             
      Inflammation                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Plasma Cell             |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             3                 2        2        2                        |             
      Hyperplasia, Macrophage              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  M  +  +  M  +  +  I  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3     2        2  3     2  2     3  3     3        2           2         |             
      Hyperplasia, Macrophage              | 2              1  1     1                                               1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation, Hemosiderin            |       3                    4                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       2                    2           3        2  4                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                          2               |             
      Ulcer                                |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                     X        X     X     X               |             
      Cranium, Hyperostosis                |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Cerebrum, Compression                |                                                                          |             
      Gray Matter, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             3                                                            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Emphysema                            |                                                                          |             
      Fibrosis                             | 2  1  3  1  1  2     2  2  2  2  1  1  1  3  1  2  4     2  3  4  2      |             
      Hemorrhage, Acute                    |                   1                                                  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|             
                                           | 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|             
    1.0                                    | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
    MG/M3                                  | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 2  2  3  1  2  2  2  3  2  3  3  3  2  3  3  2  3  3  1  2  4  3  2  1  1|             
      Metaplasia, Squamous                 |                                                       1                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    2                                                        3            |             
      Alveolus, Hyperplasia, Macrophage    | 3  3  3  3  3  2  2  3  3  3  3  2  3  3  3  3  3  2  3  2  3  3  2  3  2|             
      Alveolus, Proteinosis                | 4  4  2  4  4  4  4  4  4  2  4  1  4  4  4  2  4  4  4  4  4  4  4  4  4|             
      Bronchus, Hyperplasia, Lymphoid      | 2        2     3           2           2  1     2           2            |             
      Interstitium, Infiltration Cellular  | 2     2  2  2  2  1  2  2  1  2  1     1  1  1  1  1     1  2  1  1  1  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  2  2        1     2           3  2  1        1           1  2        1|             
      Thrombosis                           |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Olfactory Epithelium, Atrophy        |                1                 1     1  1  1           1        1     1|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         3|             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 4  2  2  2  2  2     4  3     3     4  4  3  1  4  4  1  1  2  1  1  1   |             
      Renal Tubule, Pigmentation           | 2  4  3     4  1     2  2  3  2  4     2  3  3  1  1     3  3  4         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 5| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2|                                            |            |
                                           | 1| 1| 9| 9| 1| 1| 3| 4| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  I  M  +  M  +  M  M                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Basophilic Focus                     | X     X  X  X  X  X  X     X                                             |     45     |
      Degeneration, Cystic                 |          1                                                               |      2  1.0|
      Degeneration, Fatty                  |                      2                                                   |     11  1.6|
      Eosinophilic Focus                   |                            X                                             |      5     |
      Granuloma                            |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Focal, Granulomatous   |                2                                                         |     13  1.2|
      Inflammation, Granulomatous          |                                                                          |      5  1.2|
      Mixed Cell Focus                     |                                                                          |      1     |
      Pigmentation, Hemosiderin            |                   3                                                      |      7  2.1|
      Regeneration                         |                                                                          |      2  2.5|
      Bile Duct, Hyperplasia               | 1                 2                                                      |     14  1.3|
      Centrilobular, Atrophy               |             1     2  3                                                   |     14  2.0|
      Hepatocyte, Atrophy                  |                                                                          |      1  3.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Vein, Thrombosis                     |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              | 2           2     3  3     3                                             |     14  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Squamous                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 5| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2|                                            |            |
                                           | 1| 1| 9| 9| 1| 1| 3| 4| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       | 1     1  1  1                                                            |     18  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration, Cystic                 | 2        3     2  3  3                                                   |     19  2.6|
      Hyperplasia, Focal                   |                   2     2                                                |      5  2.4|
      Hyperplasia                          |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |       3                                                                  |      6  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |          3     2     2  2                                                |     16  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Angiectasis           |          3                                                               |     16  3.0|
      Pars Distalis, Hyperplasia           |          2              1                                                |     14  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  I  +  +  +  +  +  +  +  +                                             |  57        |
      C-Cell, Hyperplasia                  |             4           3                                                |     12  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +                                             |  57        |
      Hyperplasia, Cystic                  |       4  2     3                                                         |      5  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |             X              X                                             |      6     |
      Inflammation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 5| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2|                                            |            |
                                           | 1| 1| 9| 9| 1| 1| 3| 4| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             |                   2                                                      |      3  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  4.0|
      Necrosis                             |                         4                                                |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +     +                                                |  10        |
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Macrophage  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hyperplasia, Lymphoid                | 3        2     2     2     3                                             |     38  2.5|
      Hyperplasia, Macrophage              | 1              2                                                         |     28  1.3|
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                2           3                                             |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                |                            2                                             |      6  2.3|
      Hyperplasia, Macrophage              |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Hyperplasia, Lymphoid                | 2     3  2           2     2                                             |     21  2.5|
      Hyperplasia, Macrophage              |                                                                          |      7  1.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             |             3     3                                                      |      2  3.0|
      Hematopoietic Cell Proliferation     |                         3                                                |      3  2.7|
      Pigmentation, Hemosiderin            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Cystic                  |             3     2     2                                                |     16  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperostosis                         |                                                                          |      7     |
      Cranium, Hyperostosis                |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 5| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2|                                            |            |
                                           | 1| 1| 9| 9| 1| 1| 3| 4| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hydrocephalus                        |                                                                          |      2  2.0|
      Cerebrum, Compression                |                                                                          |      5     |
      Gray Matter, Necrosis                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Inflammation                         |          2                                                               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1  1.0|
      Emphysema                            | 2                                                                        |      1  2.0|
      Fibrosis                             | 2     2  1  2  2  2  2     3                                             |     44  1.9|
      Hemorrhage, Acute                    |                                                                          |      2  1.0|
      Inflammation, Chronic Active         | 3     2  1  2  3  3  3     4                                             |     56  2.2|
      Metaplasia, Squamous                 |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             1                                                            |     11  1.6|
      Alveolus, Hyperplasia, Macrophage    |    2  2  3  3  2  3  3  3  4                                             |     57  2.7|
      Alveolus, Proteinosis                | 4  4  4  4  4  4  4  4  3  3                                             |     58  3.7|
      Bronchus, Hyperplasia, Lymphoid      | 2           2              2                                             |     19  1.8|
      Interstitium, Infiltration Cellular  | 1  1  1  1  1  2  1  2     2                                             |     48  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic Active         | 1  1        4        3                                                   |     22  2.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation      |                   3                                                      |      2  3.0|
      Olfactory Epithelium, Atrophy        | 1           1                                                            |     17  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 5| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2|                                            |            |
                                           | 1| 1| 9| 9| 1| 1| 3| 4| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|                                            |      L     |
    MG/M3                                  | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydronephrosis                       |                         3                                                |      1  3.0|
      Nephropathy                          | 2  1  2  3  4  1  1  3  1  3                                             |     52  2.3|
      Renal Tubule, Pigmentation           | 3     2  2  4  2  2  4  4  3                                             |     43  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|                                            |      A     |
    1.0                                    | 5| 6| 7| 9| 9| 9| 1| 1| 1| 2|                                            |      L     |
    LUNG TOX                               | 9| 6| 9| 1| 6| 7| 0| 3| 4| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +                                                            |   1        |
      Cyst                                 |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +     +           +  +                                             |   5        |
      Hyperplasia, Lymphoid                |    4  2     2           2  2                                             |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +     +           +  +                                             |   5        |
      Hyperplasia, Lymphoid                |    4  2     2           2  2                                             |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +           +  +                                             |   5        |
      Inflammation, Chronic Active         |    2  1     1           1  1                                             |      5  1.2|
      Alveolus, Hyperplasia, Macrophage    |    4  2     2           2  3                                             |      5  2.6|
      Alveolus, Proteinosis                |    3  3     4           4  4                                             |      5  3.6|
      Bronchus, Hyperplasia, Lymphoid      |    1  1                 1  1                                             |      4  1.0|
      Interstitium, Infiltration Cellular  |    1  1     2           1  2                                             |      5  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +           +  +                                             |   5        |
      Inflammation, Chronic Active         |    1  1                 1  1                                             |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|                                            |      A     |
    1.0                                    | 5| 6| 7| 9| 9| 9| 1| 1| 1| 2|                                            |      L     |
    LUNG TOX                               | 9| 6| 9| 1| 6| 7| 0| 3| 4| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +           +  +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|             
                                           | 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation                         | 2                                                                        |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation                         |                                  2                                       |             
      Parasite Metazoan                    |       X  X           X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         | 2                                2                                       |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               4                                          |             
      Basophilic Focus                     |    X        X        X     X     X     X        X     X  X               |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |          1     2     2           1  1           2              1     1   |             
      Degeneration, Fatty                  |                                                          4               |             
      Eosinophilic Focus                   |                            X                 X                           |             
      Hepatodiaphragmatic Nodule           |                                                    X        X            |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Bile Duct, Hyperplasia               |    1     4  1  1  3  3     3  3  3     2  1  4        3     2  2     2  2|             
      Biliary Tract, Hyperplasia           |                                                                          |             
      Centrilobular, Atrophy               |                                                 3     2     2  2         |             
      Hepatocyte, Hyperplasia              |          3                                                               |             
      Hepatocyte, Necrosis                 |    2                          4                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                    1        2        2                    3        3  2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                   3                                                      |             
      Hyperplasia, Squamous                |          3                                                               |             
      Mineralization                       |                                                                          |             
      Ulcer                                | 4                                                        4               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                               3                                          |             
      Epithelium, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|             
                                           | 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2     1  2        2     1  2  2     2  2  1  3     1  1     1     2   |             
      Embolus                              |                                                 4                        |             
      Inflammation                         |                      3                          3                        |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   | X                 X           X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                        2        3                        |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   | 1                                                                        |             
      Necrosis                             |                   1                                                      |             
      Vacuolization Cytoplasmic            | 3  2        2  2  2        2  1                          4  2  2     1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1        3  1     2  4  4        2     3     2  1  1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +|             
      Hyperplasia                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               2                                          |             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           |                      2     4  1     1  2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1     1           2                    1                              |             
      Follicle, Hyperplasia                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                 +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |          +        +  +        +  +     +  +  +  +     +  +  +  +     +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|             
                                           | 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                3           3                                             |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |    4                    2                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   4                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                   3  3                                                   |             
      Interstitial Cell, Hyperplasia       |    1              1     3  2                                      3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                               2                        |             
      Fibrosis                             |          3                                                               |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis                             |                               2                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Renal, Angiectasis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Hyperplasia, Macrophage              |          1                                                               |             
      Hyperplasia, Plasma Cell             | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                            3              3                              |             
      Inflammation                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                 3                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3  3                     |             
      Fibrosis                             |                                        3        3              3         |             
      Hematopoietic Cell Proliferation     | 3                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         | 3  3              3                       3     3        4  3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|             
                                           | 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                                         |             
      Conjunctiva, Inflammation            |                                                                          |             
      Dermis, Inflammation                 | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            X                                             |             
      Embolus                              |                                                 1                        |             
      Necrosis                             |                                                                          |             
      Cerebrum, Compression                |    X        X  X                                                         |             
      Gray Matter, Necrosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  I  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus                              |                                                 2                        |             
      Fibrosis                             |                                                       2                  |             
      Hemorrhage, Acute                    |                                                                   1      |             
      Inflammation, Chronic Active         |                      1              1  1  1                              |             
      Metaplasia, Osseous                  |                      1                       1                           |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                4         |             
      Alveolus, Hyperplasia, Macrophage    |    1  1        1                                1  1  1  1               |             
      Alveolus, Proteinosis                |                                                                          |             
      Interstitium, Infiltration Cellular  |    2  1     1  1     1  1           1  1        2     2  1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1                 1  1        1                          3           3|             
      Thrombosis                           |                               4                                          |             
      Olfactory Epithelium, Atrophy        |                                        1                    1            |             
      Olfactory Epithelium, Mineralization,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|             
                                           | 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                 +                                             |             
      Cataract                             |                                                                          |             
      Inflammation                         |                            4                                             |             
      Phthisis Bulbi                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         X|             
      Embolus                              |                                                 2                        |             
      Infarct                              |                               4                                          |             
      Inflammation                         |                                                 3                        |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  3  1  4  4  3  1  4  1  2  3  4  1  4  2  2  4  1  4  4  2  4  1  2  4|             
      Renal Tubule, Pigmentation           |          3                       3     2  3  3              3  2        2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |       X                 X                                X               |             
      Calculus Micro Observation Only      |    X                                X                                    |             
      Congestion                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|             
                                           | 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       2                  |             
      Mineralization                       |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  I     +  +  M  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  M  +|             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            3                                3            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                4                                               4         |             
      Basophilic Focus                     | X        X  X  X  X           X     X        X     X  X  X  X     X      |             
      Clear Cell Focus                     |                               X                                          |             
      Degeneration, Cystic                 |                                        1                                 |             
      Degeneration, Fatty                  | 4              2     4  2  1                    3              3         |             
      Eosinophilic Focus                   |    X     X              X                                            X   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Focal, Granulomatous   |                               1                                          |             
      Bile Duct, Hyperplasia               |          3  1  3  1  2  3  1  1        1        1  2  4     1  3  2  2  1|             
      Biliary Tract, Hyperplasia           |                                        4                                 |             
      Centrilobular, Atrophy               |          2                                   2  3     3        3  1     1|             
      Hepatocyte, Hyperplasia              | 1                                                                        |             
      Hepatocyte, Necrosis                 | 1                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                 4           2                 2     2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                2                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
      Epithelium, Mineralization           |                4                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|             
                                           | 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dysplasia                            |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
      Mineralization                       |                4                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1        2  2  3     2  2  2  3  1  2           2  2     2  2  2      |             
      Embolus                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                4                                                         |             
      Atrium, Thrombosis                   |          X           X  X                             X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Diffuse                 |                            3                                             |             
      Hyperplasia, Focal                   |                                                                      3   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                      4                 3        3           2     3  4   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              3        2              2     2  2     2     2     3  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                      3           3  3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                      3   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          3  2  3  4     3           3        1  1     4        3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                         1                     |             
      Follicle, Hyperplasia                |                         4                                                |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +        +  +     +  +  +  +  +  +     +     +     +        +  +     +  +|             
      Inflammation                         |                            3                                             |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|             
                                           | 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                            3                                             |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                2         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                3        4                                      3         |             
      Interstitial Cell, Hyperplasia       |                3                    3  1        2              3  2     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3  2                                                      |             
      Fibrosis                             |                      4                                                   |             
      Inflammation, Focal, Granulomatous   |                            1                                             |             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                +  +      |             
      Renal, Angiectasis                   |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                3         |             
      Hyperplasia, Lymphoid                | 2        2                                                  3            |             
      Hyperplasia, Macrophage              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            3           3     3                           |             
      Hyperplasia, Plasma Cell             |    4                          2                    3                     |             
      Inflammation                         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                4         |             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                            3           3     2     3        1            |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  +  +  +  +  +  +  +  +  +  +     I  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          |                                                                4         |             
      Hyperplasia, Lymphoid                |                                                    3                     |             
      Inflammation                         |                      4                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                                                     |             
      Fibrosis                             |          3              4                    4     3                 3   |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |    4        3  3     2                 3                             4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|             
                                           | 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  I     +  +  M  M  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                        1     2                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                    X                     |             
      Conjunctiva, Inflammation            |                                                                          |             
      Dermis, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                X                                                         |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Embolus                              |                                                                          |             
      Necrosis                             |                                                                          |             
      Cerebrum, Compression                |                                        X                                 |             
      Gray Matter, Necrosis                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | I  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                       2  2              2         |             
      Inflammation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Embolus                              |                                                                          |             
      Fibrosis                             |                                              2                           |             
      Hemorrhage, Acute                    | 1                                1  1        1  1        1               |             
      Inflammation, Chronic Active         | 1              2              1              3                           |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                4                                                         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Hyperplasia, Macrophage    | 1                          1                 2                           |             
      Alveolus, Proteinosis                |                                              1                           |             
      Interstitium, Infiltration Cellular  | 1                          1  1  1                          1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2           2              2  2                 2  2              1   |             
      Thrombosis                           |                                                 1     2                  |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Mineralization,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|             
                                           | 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         3|             
      Inflammation                         |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Embolus                              |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                3                                                         |             
      Nephropathy                          | 4        4  2  4  2  3  4  2  4     1  4     3  1  4  4  1  4  2  4  3  2|             
      Renal Tubule, Pigmentation           |          4           2  2                    4     1  3     1  4  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                    X                     |             
      Calculus Micro Observation Only      |                                     X                                X   |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 7| 5| 7| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3|                                            |            |
                                           | 6| 7| 9| 1| 6| 7| 6| 5| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Inflammation                         |                         1                                                |      3  1.7|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  I  +  +  +  +  +                                             |  51        |
      Inflammation                         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      2  2.0|
      Parasite Metazoan                    |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |    2        3                                                            |      4  2.8|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      3  4.0|
      Basophilic Focus                     | X     X  X  X  X  X  X                                                   |     29     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |          1           1                                                   |     11  1.3|
      Degeneration, Fatty                  |                4                                                         |      9  3.0|
      Eosinophilic Focus                   |                                                                          |      6     |
      Hepatodiaphragmatic Nodule           |       X                                                                  |      3     |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 2  2  2  2  1           2                                                |     40  2.1|
      Biliary Tract, Hyperplasia           |                                                                          |      1  4.0|
      Centrilobular, Atrophy               |       1                                                                  |     12  2.1|
      Hepatocyte, Hyperplasia              |    3                                                                     |      3  2.3|
      Hepatocyte, Necrosis                 |    2                                                                     |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              | 2        3                 2                                             |     15  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                | 3              4                                                         |      4  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 7| 5| 7| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3|                                            |            |
                                           | 6| 7| 9| 1| 6| 7| 6| 5| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Epithelium, Mineralization           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Dysplasia                            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       |    2     1  3  2  2                                                      |     37  1.9|
      Embolus                              |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      2  3.0|
      Mineralization                       |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      7     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Degeneration, Cystic                 |                                                                          |      2  2.5|
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                            2                                             |      3  2.0|
      Necrosis                             | 3                                                                        |      2  2.0|
      Vacuolization Cytoplasmic            | 3        3  3  3     3  2                                                |     23  2.6|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          | 4  2        2     1  2                                                   |     26  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +                                             |  55        |
      Hyperplasia                          | 2           2           3                                                |      8  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Angiectasis           |    2              4                                                      |      4  2.8|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |    4        4                                                            |     17  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      C-Cell, Hyperplasia                  |       1                                                                  |      7  1.1|
      Follicle, Hyperplasia                |                                                                          |      1  4.0|
      Follicular Cell, Hyperplasia         | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 7| 5| 7| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3|                                            |            |
                                           | 6| 7| 9| 1| 6| 7| 6| 5| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +     +  +  +  +     +                                             |  39        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +  +                                             |   2        |
      Concretion                           |                         3  3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectasia                              |                                                                          |      2  3.0|
      Hyperplasia                          |             3           4                                                |      3  3.3|
      Inflammation                         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Germinal Epithelium, Degeneration    | 3                       2                                                |      7  3.0|
      Interstitial Cell, Hyperplasia       |          2                 3                                             |     14  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      4  2.5|
      Fibrosis                             |                                                                          |      2  3.5|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                          +                                             |   5        |
      Renal, Angiectasis                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +                                             |  57        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |       2                                                                  |      5  2.2|
      Hyperplasia, Macrophage              |                                                                          |      1  1.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +                                             |  55        |
      Hyperplasia, Lymphoid                |       2                                                                  |      4  2.8|
      Hyperplasia, Plasma Cell             |                   2                                                      |      6  2.8|
      Inflammation                         |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 7| 5| 7| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3|                                            |            |
                                           | 6| 7| 9| 1| 6| 7| 6| 5| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  4.0|
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.4|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +                                             |  53        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      3  3.3|
      Fibrosis                             |       2     3                                                            |     10  3.1|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  I  +  +  +  +  +                                             |  55        |
      Degeneration                         |                3     3  3  2                                             |     17  3.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Hyperplasia, Cystic                  |       1        1  2  2  1                                                |      8  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Conjunctiva, Inflammation            |                         4                                                |      1  4.0|
      Dermis, Inflammation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrous Osteodystrophy               |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Compression                          |                                                                          |      1     |
      Embolus                              |                                                                          |      1  1.0|
      Necrosis                             |                         4                                                |      1  4.0|
      Cerebrum, Compression                |                X     X                                                   |      6     |
      Gray Matter, Necrosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 7| 5| 7| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3|                                            |            |
                                           | 6| 7| 9| 1| 6| 7| 6| 5| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia                          |                                                                          |      4  2.0|
      Inflammation                         |                            1                                             |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Embolus                              |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      2  2.0|
      Hemorrhage, Acute                    |                                                                          |      7  1.0|
      Inflammation, Chronic Active         |                         1                                                |      9  1.3|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       2                                                                  |      2  3.0|
      Alveolus, Hyperplasia, Macrophage    |                                                                          |     10  1.1|
      Alveolus, Proteinosis                |                                                                          |      1  1.0|
      Interstitium, Infiltration Cellular  |          1  1        1                                                   |     19  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic Active         |                                                                          |     13  1.8|
      Thrombosis                           |                                                                          |      3  2.3|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.0|
      Olfactory Epithelium, Mineralization,|                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   4        |
      Cataract                             |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  4.0|
      Phthisis Bulbi                       |          X                                                               |      1     |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Cyst                                 |                                                                          |      1     |
      Embolus                              |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy                          | 4  4  2  4  4  4  4  4  4  3                                             |     56  2.9|
      Renal Tubule, Pigmentation           |       3           1                                                      |     20  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 7| 5| 7| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3|                                            |            |
                                           | 6| 7| 9| 1| 6| 7| 6| 5| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Calculus Gross Observation           |                                                                          |      4     |
      Calculus Micro Observation Only      |             X                                                            |      5     |
      Congestion                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 0| 0| 1| 2| 2| 3| 5| 5| 5| 6|                                            |      L     |
    LUNG TOX                               | 1| 2| 4| 0| 4| 5| 0| 8| 9| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    I  +  +     +        +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +  +     +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +     +        +                                                |   5        |
      Inflammation, Chronic Active         |    1                                                                     |      1  1.0|
      Interstitium, Infiltration Cellular  |          1     1        1                                                |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +     +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +     +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +              +                                                |   3        |
      Calculus Micro Observation Only      |    X                    X                                                |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|             
                                           | 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                    3                 3   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X        X     X  X        X        X  X           X        X  X     X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 3              1  1  2           2        2     1                       1|             
      Degeneration, Fatty                  |                                                          2               |             
      Eosinophilic Focus                   | X        X              X                 X     X                        |             
      Hepatodiaphragmatic Nodule           |                            X                                             |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Bile Duct, Hyperplasia               | 4  4  4     3     4  2  3  1     3  1  2  3  3  3  1     2  2  2        1|             
      Centrilobular, Atrophy               |    2        2        2                    2                 2            |             
      Hepatocyte, Hyperplasia              |                   1                                                      |             
      Hepatocyte, Necrosis                 |       4     1                                   2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                    2     2        2                          2   |             
      Hyperplasia                          |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Hyperkeratosis                       |                      3           3        3                              |             
      Ulcer                                |                                                          4               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |       2                                                                  |             
      Epithelium, Mineralization           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Dysplasia                            |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  1     1  2  1  3  2     2              2  1     2  2     2  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|             
                                           | 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |       X           X              X                          X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Focal                   |                         3                                                |             
      Vacuolization Cytoplasmic            |    2                                      3     3     3  2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  2  3  1  2                    2           3  2     1     2     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          | 4                                3                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                        3                          3  3   |             
      Pars Distalis, Cyst                  |             X                                                            |             
      Pars Distalis, Hyperplasia           |       4  1                 4                       4                    4|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1           2                    2     1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +     +   |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                         3                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                          4               |             
      Inflammation                         |             2                    2                                2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2     2                                               2         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     2                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |       3        3  2  4              2              3                 4  3|             
      Interstitial Cell, Hyperplasia       |       1     3  3  1        2  3     2           1           2     2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                         2                        |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|             
                                           | 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                             3            |             
      Myeloid Cell, Hyperplasia            |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +     +        +        +  +  +                        |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Ectasia                              |       3                                                                  |             
      Hyperplasia, Lymphoid                | 1  2     3  2  2           2  2     3  3           2     2     3     2  2|             
      Hyperplasia, Macrophage              | 1  1        1                 1                 2                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          3              2|             
      Hyperplasia, Plasma Cell             |          3  3                                         4                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            2        2              3  2                 2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       3                                            2     2              1|             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Fibrosis                             | 3     3  3        3  3  2        3                             4         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                  4                                       |             
      Pigmentation, Hemosiderin            |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Degeneration                         |                                                       2  4  3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +|             
      Hyperplasia, Cystic                  |                2     1                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                      X                                                   |             
      Tail, Hyperkeratosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |    X  X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                |                                                          X               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|             
                                           | 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 1           1            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Emphysema                            |                            1                                             |             
      Fibrosis                             | 3  1  2  2  1  2  2  2  1  2     1  2  2  2  2  1  2     2  2  3  1  3   |             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Chronic Active         | 2  2  3  3  2  3  3  3  2  3  2  2  3  3  3  3  2  3  1  3  3  3  2  3  3|             
      Metaplasia, Osseous                  |                                                                         1|             
      Metaplasia, Squamous                 |                                     1     1                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                     2  2                             4   |             
      Alveolus, Hyperplasia, Macrophage    | 2  1  3  3  3  3  2     1  3  2     3  2        1  3  2  1     3  2  3  2|             
      Alveolus, Proteinosis                |       1  2  2  1           2  2     1  1        1  1  1        1     1  1|             
      Bronchus, Hyperplasia, Lymphoid      |                            2        2  2           2           1         |             
      Interstitium, Infiltration Cellular  | 2        1  1  1     1     2  1     1  2           2  1     2  2     1  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                      1   |             
      Inflammation, Chronic Active         | 1     2                             1  4        4        3              2|             
      Thrombosis                           |                      1                                                   |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Hemorrhage, Chronic|    3                                                                     |             
      Iris, Inflammation                   |                                                                          |             
      Retina, Degeneration                 |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X        X                                                               |             
      Nephropathy                          | 4  3  3  4  2  4  3  2  3  4  1  4  4  4  3  4  3  4  1  2  2  4  2  4  3|             
      Renal Tubule, Pigmentation           |    2  2  2  4  2     2  3        4  2  2  3  4  4           4  1  3      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +               |             
      Calculus Micro Observation Only      |                                                          X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |             X                                                            |             
      Calculus Micro Observation Only      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|             
                                           | 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    MG/M3                                  | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                 X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          2     3     3   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X           X  X     X  X  X  X  X  X  X              X  X  X     X  X|             
      Clear Cell Focus                     |                                     X                                    |             
      Degeneration, Cystic                 |                1                       2                          1      |             
      Degeneration, Fatty                  |             3                                                            |             
      Eosinophilic Focus                   | X                                                                        |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Focal, Granulomatous   |    1           1                                                         |             
      Bile Duct, Hyperplasia               |    1     2  2        2     3  1  2     3  1  2  2        2  2  1  3  1  3|             
      Centrilobular, Atrophy               |          4  4  3     3     1           2                          2     2|             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                      2                       2        3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fat, Necrosis                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                      2     2     3                    2  2        3      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Infarct                              |                               3                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Diverticulum                         |                                  4                                       |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                   2      |             
      Epithelium, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1  2        2     2  2  2     1     1        2  2  1     1  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|             
                                           | 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    MG/M3                                  | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Degeneration, Cystic                 | 2                                2                                       |             
      Hyperplasia, Focal                   |                                        3                                 |             
      Vacuolization Cytoplasmic            |                                        2                    2            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                1              1        2  2  1     2  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2     2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          3                             3                       3  2  3   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  1           4              2                          1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                  2                                   2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +     +  +  +     +     +  +  +     +     +        +  +     +  +  +  +|             
      Inflammation                         |                                                                      3  3|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                 3                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Ectasia                              |                                              3                           |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                   3                                                  1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |          3                                               3        4     3|             
      Interstitial Cell, Hyperplasia       |    2        1     3                 1                 2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                         |             
      Inflammation, Focal, Granulomatous   |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|             
                                           | 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    MG/M3                                  | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +           +                       +  +     +           +      |             
      Iliac, Hyperplasia, Lymphoid         |                                                       3                  |             
      Renal, Pigmentation                  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                | 2  1     1     1  2     1  2  3  3  2     1              2  3  2     2   |             
      Hyperplasia, Macrophage              |                   1     1  1  1  1        1                 1  2     1   |             
      Hyperplasia, Plasma Cell             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          3                    3  4                                       |             
      Hyperplasia, Plasma Cell             |                      3     4           3                    3  3     2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2        2                 2                             2  3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2     2  2        4     2     2     3                 2  2        2   |             
      Hyperplasia, Macrophage              |                                           1                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                            3     3                       4     3         |             
      Hyperplasia, Lymphoid                | 2                                                        3           2   |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  M  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M     +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Tail, Hyperkeratosis                 |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperostosis                         |             X                                         X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cerebrum, Compression                |                                                                         X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|             
                                           | 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    MG/M3                                  | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Emphysema                            |                                                                          |             
      Fibrosis                             | 2  4     1     1     2     2  1  1     2     1        2  2  2  1  2  1  1|             
      Hemorrhage, Acute                    |                                           1                              |             
      Inflammation, Chronic Active         | 3  2     2  2  3  1  3  1  3  3  2  2  3  1  2  1     3  3  2  2  3  1  2|             
      Metaplasia, Osseous                  |                         1                                                |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        2                       1         |             
      Alveolus, Hyperplasia, Macrophage    | 3  3     2  2  3  2  3  2  3  3  2  2  3  2  3  2     2  3  2  2  3  2  2|             
      Alveolus, Proteinosis                |    1     1  1  1  1  2  1     1  1  2  2  2  2  1     2  1  1     1  1  2|             
      Bronchus, Hyperplasia, Lymphoid      | 1  2                                                        2        1   |             
      Interstitium, Infiltration Cellular  | 1  2              2        3  1  1  1     1              2  2  2     2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                   1     1                                      4        2|             
      Thrombosis                           |             1                                1                           |             
      Olfactory Epithelium, Atrophy        |                                                                      1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                 +      |             
      Cataract                             | 4                                                                 4      |             
      Anterior Chamber, Hemorrhage, Chronic|                                                                          |             
      Iris, Inflammation                   |                                                                          |             
      Retina, Degeneration                 | 3                                                                 3      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 4  3     2  2  1  1  2  1  4  4  4  1  4  1  4  1     4  4  4  4  2  4  3|             
      Renal Tubule, Pigmentation           | 2        3  4        2     4     1     2                 2  1     4  1  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                           X                              |             
      Calculus Micro Observation Only      |                         X                             X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 5| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3|                                            |            |
                                           | 3| 1| 6| 3| 7| 3| 4| 0| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/M3                                  | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  M  M  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +                                             |  54        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                         1                                                |      1  1.0|
      Basophilic Focus                     |    X  X  X  X  X        X  X                                             |     35     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 | 1  1        1        1                                                   |     15  1.4|
      Degeneration, Fatty                  |                                                                          |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      6     |
      Hepatodiaphragmatic Nodule           |          X                                                               |      2     |
      Inflammation, Focal, Granulomatous   |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               | 4  3  3  2  3  1  2     2  1                                             |     45  2.3|
      Centrilobular, Atrophy               |    2              2        3                                             |     16  2.4|
      Hepatocyte, Hyperplasia              |                                                                          |      1  1.0|
      Hepatocyte, Necrosis                 |                            1                                             |      7  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              | 3  3     3        3                                                      |     15  2.4|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Infarct                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Diverticulum                         |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      3  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Epithelium, Mineralization           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 5| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3|                                            |            |
                                           | 3| 1| 6| 3| 7| 3| 4| 0| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/M3                                  | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dysplasia                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       | 1  2  1  2  1  1  1        1                                             |     37  1.5|
      Atrium, Thrombosis                   |             X                                                            |      6     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      1  3.0|
      Degeneration, Cystic                 |                            3                                             |      3  2.3|
      Hyperplasia, Focal                   |                                                                          |      2  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +                                             |  57        |
      Hyperplasia                          | 2                       2  3                                             |     22  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +                                             |  55        |
      Hyperplasia                          |       2                    2                                             |      6  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Pars Distalis, Angiectasis           |                            2                                             |      9  2.8|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |    2                    1                                                |     12  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      C-Cell, Hyperplasia                  | 1                                                                        |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Inflammation                         | 2                                                                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Granuloma Sperm                      |                   3                                                      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation                         |                         2                                                |      6  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 5| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3|                                            |            |
                                           | 3| 1| 6| 3| 7| 3| 4| 0| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/M3                                  | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Germinal Epithelium, Degeneration    |                3                                                         |     13  3.1|
      Interstitial Cell, Hyperplasia       |                            1                                             |     16  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  M  +                                             |  57        |
      Atrophy                              |                                                                          |      3  2.3|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +     +                                                      |  16        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |       1  2     2     3  2                                                |     34  2.0|
      Hyperplasia, Macrophage              |       1  1     1        1                                                |     18  1.1|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +                                             |  56        |
      Hyperplasia, Lymphoid                |          2     2                                                         |      7  2.7|
      Hyperplasia, Plasma Cell             |    3                                                                     |     10  3.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                1                                                         |     11  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  M  +  M  +  +                                             |  54        |
      Hyperplasia, Lymphoid                |                         3                                                |     15  2.3|
      Hyperplasia, Macrophage              |                         1                                                |      2  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                            3                                             |      2  3.0|
      Fibrosis                             |                            4                                             |     13  3.2|
      Hyperplasia, Lymphoid                |                3                                                         |      4  2.5|
      Infarct                              |                   4                                                      |      2  4.0|
      Pigmentation, Hemosiderin            |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Degeneration                         |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M                                             |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 5| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3|                                            |            |
                                           | 3| 1| 6| 3| 7| 3| 4| 0| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/M3                                  | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Tail, Hyperkeratosis                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  M  +                                             |  57        |
      Hyperostosis                         |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cerebrum, Compression                | X                    X                                                   |      4     |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Emphysema                            |                                                                          |      1  1.0|
      Fibrosis                             | 1     2  1  2  2  1  2  2  2                                             |     48  1.8|
      Hemorrhage, Acute                    |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 2  2  3  2  2  4  2  2  3  2                                             |     58  2.4|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Metaplasia, Squamous                 |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                2                                                         |      6  2.2|
      Alveolus, Hyperplasia, Macrophage    | 2  3  3  2  2  3  3  3  3  2                                             |     53  2.4|
      Alveolus, Proteinosis                | 2     1  1     1  2  2  1                                                |     41  1.3|
      Bronchus, Hyperplasia, Lymphoid      |                2                                                         |     10  1.7|
      Interstitium, Infiltration Cellular  | 1     1  3     1  1  2  2  1                                             |     35  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                   3                                                      |     12  2.3|
      Thrombosis                           |                                                                          |      3  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 5| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3|                                            |            |
                                           | 3| 1| 6| 3| 7| 3| 4| 0| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.15                                   | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/M3                                  | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                                                                          |      2  4.0|
      Anterior Chamber, Hemorrhage, Chronic|                                                                          |      1  3.0|
      Iris, Inflammation                   |    2                                                                     |      1  2.0|
      Retina, Degeneration                 |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      2     |
      Nephropathy                          | 3  3  4  4  4  4  3  2  4  4                                             |     58  3.0|
      Renal Tubule, Pigmentation           | 2  3  2     2  1     2  2                                                |     35  2.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Calculus Micro Observation Only      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Calculus Gross Observation           |                                                                          |      2     |
      Calculus Micro Observation Only      |                                                                          |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|                                            |      A     |
    0.15                                   | 4| 5| 5| 7| 8| 8| 9| 9| 0| 0|                                            |      L     |
    LUNG TOX                               | 7| 0| 8| 6| 2| 5| 6| 8| 0| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +        +     +  +  +                                                |   5        |
      Hyperplasia, Lymphoid                |    1        1     1  1                                                   |      4  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +        +     +  +  +                                                |   5        |
      Hyperplasia, Lymphoid                |    2        1     1  1  1                                                |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +     +  +  +                                                |   5        |
      Inflammation, Chronic Active         |    1        1     1  1  2                                                |      5  1.2|
      Metaplasia, Osseous                  |                         1                                                |      1  1.0|
      Alveolus, Hyperplasia, Macrophage    |    2        2     2  2  2                                                |      5  2.0|
      Alveolus, Proteinosis                |    1        1     1                                                      |      3  1.0|
      Bronchus, Hyperplasia, Lymphoid      |                         2                                                |      1  2.0|
      Interstitium, Infiltration Cellular  |    1        1     1  1  1                                                |      5  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +     +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|                                            |      A     |
    0.15                                   | 4| 5| 5| 7| 8| 8| 9| 9| 0| 0|                                            |      L     |
    LUNG TOX                               | 7| 0| 8| 6| 2| 5| 6| 8| 0| 4|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +     +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +     +  +  +                                                |   4        |
      Calculus Micro Observation Only      |             X     X  X  X                                                |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|             
                                           | 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X     X     X  X  X        X  X  X  X        X  X        X  X   |             
      Degeneration, Cystic                 |                1  2  1           1           1     2  1  2        1      |             
      Degeneration, Fatty                  |                                                                   1      |             
      Eosinophilic Focus                   |                                                       X  X     X         |             
      Hepatodiaphragmatic Nodule           |             X                                                            |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                 1                        |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Thrombosis                           |                                        X                                 |             
      Bile Duct, Hyperplasia               | 2  2  4     1  1  1  1     2  2  4  3  3        2     2  4  3  3        3|             
      Centrilobular, Atrophy               |                   3                                                     3|             
      Hepatocyte, Hyperplasia              |                                                          3               |             
      Hepatocyte, Necrosis                 |    2              2                 2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  3     1     2        3  2        2  1        2  3  1     3  1      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                   4                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                   1                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|             
                                           | 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2     2        1     2  1  3  2  2  2           2     1  2  2  2   |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   | X                                                        X           X   |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                           2                              |             
      Hyperplasia, Focal                   |                                                             2            |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 1  3  2           1           2  3     3                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 4     1                          3        2            |             
      Bilateral, Thrombosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Pars Distalis, Angiectasis           |                                                                      4  3|             
      Pars Distalis, Cyst                  |                                     X                             X      |             
      Pars Distalis, Hyperplasia           |          1                    3           2              2        2     3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4  3                 1     1                                   1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +     +     +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              3                           |             
      Hyperplasia                          |                      4                                                   |             
      Inflammation                         |             2                                   2                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|             
                                           | 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |       3                             3                                    |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |    4  4                          4     3                       1  3      |             
      Interstitial Cell, Hyperplasia       |                3  2        1  2  2     3  1     1  3        2     1     3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                           |             
      Fibrosis                             |                                                                          |             
      Granuloma                            |                                                 2                        |             
      Inflammation, Suppurative            |                                                                         3|             
      Myeloid Cell, Hyperplasia            |                               3                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +                             +               |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2     3           3  2     2  2     2  3  3     3           3  4  3   |             
      Hyperplasia, Macrophage              |    1     2  2  1     1  1     1  1     2  1  2     1           1  1  1   |             
      Hyperplasia, Plasma Cell             |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                3         |             
      Hyperplasia, Plasma Cell             |    2                                         3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3        3         |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I|             
      Hyperplasia, Lymphoid                |                                        4                       2  3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                                            |             
      Fibrosis                             |             3                    3        4           3                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Degeneration                         | 4           4  4  4           4  4  4  4     3     3                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  I  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Subcutaneous Tissue, Inflammation    |                                                                          |             
      Tail, Hyperkeratosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|             
                                           | 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Mandible, Necrosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Cerebrum, Atrophy, Focal             |                                                                          |             
      Cerebrum, Compression                |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1     1                                                            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Emphysema                            |                                                                          |             
      Fibrosis                             |       2     2        1     1     1     1  2           1     1  1  4  1  2|             
      Inflammation, Chronic Active         | 3  4  3  1  3  3  1  2  1  2  2  2  3  4  2  3  2  3  3  3  2  2  3  3  2|             
      Metaplasia, Osseous                  |                         1                                                |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             3                       3                                    |             
      Alveolus, Emphysema                  |                         2                                                |             
      Alveolus, Hyperplasia, Macrophage    | 2  2  3  2  3  3  3  4  2  2  3  3  3  4  3  3  2  3  3  3  3  3  3  3  3|             
      Alveolus, Proteinosis                | 4  3     4  3  4  4  4  4     4  3  1  4  4  4  4  4  4  3  4  4  3  4  2|             
      Bronchus, Hyperplasia, Lymphoid      |                                           2           3           2  2   |             
      Interstitium, Infiltration Cellular  | 1     2  2     2     3  2     2  1  2  3  3  2  3  2  3  2     3  3  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3           4              3  4                       4  3        1  4|             
      Thrombosis                           |                   1                                                      |             
      Nasolacrimal Duct, Inflammation      |                      2                                                   |             
      Olfactory Epithelium, Atrophy        |    2           1              1  1                                       |             
      Olfactory Epithelium, Mineralization,|                                                                          |             
           Focal                           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                 +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|             
                                           | 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/M3                                  | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  3  4  1  3  2  2  4  1  4  2  3  4  2  4  4  1  2  4  2  3  3  4  4  3|             
      Cortex, Infarct                      |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Pigmentation           | 2     2           1        3  4  3  2  3  2  3        1  4  2  2  1  2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         X                                                |             
      Inflammation                         |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|             
                                           | 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |          2  3                                               1            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                | 3                                                                 3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3  2                       2                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X           X  X     X  X           X     X     X  X  X  X     X   |             
      Degeneration, Cystic                 | 1           3                             2        1           3         |             
      Degeneration, Fatty                  |          2                    1  2                                      2|             
      Eosinophilic Focus                   |    X                                                     X  X            |             
      Hepatodiaphragmatic Nodule           |                                  X                    X           X      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                   2      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 1  3  1  2  3  3  1                 3     2  1  2  3        3  1  2      |             
      Centrilobular, Atrophy               |          4  4  3                    3     2        2                    2|             
      Hepatocyte, Hyperplasia              |    2                                                                     |             
      Hepatocyte, Necrosis                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Inflammation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1           2  3  3  3     2                                3  3  3      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |    3                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |             3  3                          3                             2|             
      Ulcer                                |                               3           4                             4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |             2                                                           2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|             
                                           | 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
      Inflammation                         |                                                                3         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1              1  2     1  1           1  1  1  2     2  2  2  1      |             
      Mineralization                       |                               3                                          |             
      Atrium, Thrombosis                   |                                                                   X      |             
      Valve, Thrombosis                    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2                    1                       2                    1      |             
      Hyperplasia, Focal                   |          2                                                               |             
      Necrosis                             |                1                                                         |             
      Vacuolization Cytoplasmic            |          4                 2     3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                    2     1  2                                    |             
      Bilateral, Thrombosis                |                   4                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                2         |             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           | 1     2     1        2                       1              1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +  +  +  +  +     +  +  +  +     +  +     +     +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3                                                                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                               3                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|             
                                           | 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Epithelium, Hyperplasia              |                               3                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                   2              2              3        2        2      |             
      Interstitial Cell, Hyperplasia       | 3           2     2           1           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      2   |             
      Fibrosis                             |             2                                                            |             
      Granuloma                            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                +         |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3        1  1     1  4     2  2     2     2     4     2  1     4     1  2|             
      Hyperplasia, Macrophage              | 1        1  1  1  1  1     1                    2     1        2        1|             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  M  +  +  +  +  M  +  M  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Hyperplasia, Plasma Cell             |                                  3                       3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   1  2                                                   |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1                    2                                3        2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             | 3  4        3  3                                   2        3     2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                               2  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  M  M  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                              X                           |             
      Subcutaneous Tissue, Inflammation    |                                                                         3|             
      Tail, Hyperkeratosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|             
                                           | 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                    X                     |             
      Mandible, Necrosis                   |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cerebrum, Atrophy, Focal             |                                                                          |             
      Cerebrum, Compression                |                                  X                                   X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Emphysema                            |       2                                                                  |             
      Fibrosis                             | 1  2  1  1  4     1  3     2  3  2  2     2  1  2  3     2  2     1  1  1|             
      Inflammation, Chronic Active         | 3  3  2  2  3     3  4     2  3  3  3     2  2  3  4  1  4  3  2  3  2  3|             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                               2                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          2           3     3                 1  2           1  2  1      |             
      Alveolus, Emphysema                  |                                                                          |             
      Alveolus, Hyperplasia, Macrophage    | 3  2  3  3  3     4  3     3  3  4  3     3  3  3  3  3  4  2  3  3  3  3|             
      Alveolus, Proteinosis                | 4  2  4  4  3  4  4  4     4  4  4  4     3  3  4  2  4  4  4  4  4  4  4|             
      Bronchus, Hyperplasia, Lymphoid      | 2     2           2  2                          3        3     2     2   |             
      Interstitium, Infiltration Cellular  | 2     1  1        2  3     2  3  2  2     1     2     2  2  1  3     2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                             1                                1  1     3|             
      Thrombosis                           |                1                                                  1     1|             
      Nasolacrimal Duct, Inflammation      |                                                                2  2      |             
      Olfactory Epithelium, Atrophy        |                                                          1        1     1|             
      Olfactory Epithelium, Mineralization,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Hydronephrosis                       |                               3                                          |             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|             
                                           | 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                               2                                          |             
      Nephropathy                          | 4  3  4  2  3  3  4  4     2  4  3  2     4  4  4  4  1  4  4  4  4  4  3|             
      Cortex, Infarct                      |    3        2                                                            |             
      Papilla, Necrosis                    |                               4                                          |             
      Renal Tubule, Pigmentation           | 1  3     2  3  3                 2  2     1  2  2                 2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                      X        X                                          |             
      Inflammation                         |                                                             2     2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 4| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6|                                            |            |
                                           | 6| 0| 1| 6| 8| 6| 8| 4| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.0                                    | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/M3                                  | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M                                             |  57        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +                                             |  57        |
      Hyperplasia, Lymphoid                | 4                                                                        |      1  4.0|
      Inflammation                         |    4                                                                     |      4  2.5|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +                                             |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Basophilic Focus                     | X  X     X  X  X        X  X                                             |     35     |
      Degeneration, Cystic                 |          1                                                               |     15  1.5|
      Degeneration, Fatty                  |                1           1                                             |      7  1.4|
      Eosinophilic Focus                   |                                                                          |      6     |
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                            1                                             |      1  1.0|
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2  1  1        1  1     2                                                |     39  2.1|
      Centrilobular, Atrophy               | 1  1  1                 1                                                |     13  2.3|
      Hepatocyte, Hyperplasia              |                                                                          |      2  2.5|
      Hepatocyte, Necrosis                 |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |          2                 3                                             |     25  2.3|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Infarct                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Squamous                |                         3                                                |      5  2.8|
      Ulcer                                |                   3     3                                                |      6  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 4| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6|                                            |            |
                                           | 6| 0| 1| 6| 8| 6| 8| 4| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.0                                    | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/M3                                  | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Necrosis, Focal                      |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       | 1  1  1  1     2     2  2                                                |     36  1.6|
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      4     |
      Valve, Thrombosis                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration, Cystic                 |                                                                          |      5  1.6|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                2  3                                                      |     12  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                      3     2                                             |     11  2.3|
      Bilateral, Thrombosis                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +                                             |  56        |
      Hyperplasia                          |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Angiectasis           |                                                                          |      3  3.0|
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hyperplasia           |                         4                                                |     13  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      C-Cell, Hyperplasia                  |       2                                                                  |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +        +     +  +  +                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 4| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6|                                            |            |
                                           | 6| 0| 1| 6| 8| 6| 8| 4| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.0                                    | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/M3                                  | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectasia                              |                                                                          |      2  3.0|
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation                         |    2                                                                     |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |                                                                          |      2  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Germinal Epithelium, Degeneration    |    3     3                                                               |     13  2.8|
      Interstitial Cell, Hyperplasia       |             2                                                            |     18  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      2  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Granuloma                            |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |       3  3                                                               |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   6        |
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                | 4  3  2  2  1  2     2  1  3                                             |     38  2.3|
      Hyperplasia, Macrophage              | 1  1  1     1  1           1                                             |     32  1.2|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia, Lymphoid                |       3                                                                  |      3  2.7|
      Hyperplasia, Plasma Cell             |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                      1  1                                                |      6  1.8|
      Hyperplasia, Macrophage              |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +                                             |  53        |
      Hyperplasia, Lymphoid                | 2                          2                                             |      9  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 4| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6|                                            |            |
                                           | 6| 0| 1| 6| 8| 6| 8| 4| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.0                                    | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/M3                                  | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |          3                                                               |     12  3.0|
      Hemorrhage                           |                   3                                                      |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                            2                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M                                             |  53        |
      Degeneration                         |                                                                          |     10  3.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  +  +  +  +  +  +                                             |  48        |
      Hyperplasia, Cystic                  |                      2     2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Subcutaneous Tissue, Inflammation    |                                                                          |      1  3.0|
      Tail, Hyperkeratosis                 |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperostosis                         |                                                                          |      1     |
      Mandible, Necrosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
      Cerebrum, Atrophy, Focal             |          4                                                               |      1  4.0|
      Cerebrum, Compression                |                            X                                             |      4     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  I  +  +  +                                             |  57        |
      Inflammation                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Emphysema                            |                                                                          |      1  2.0|
      Fibrosis                             |    2  2  2     2     1  1  1                                             |     40  1.7|
      Inflammation, Chronic Active         | 1  3  2  2  1  2     1  2  2                                             |     56  2.5|
      Metaplasia, Osseous                  |                   1                                                      |      2  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                                                                     |     11  2.1|
      Alveolus, Emphysema                  |                                                                          |      1  2.0|
      Alveolus, Hyperplasia, Macrophage    | 3  3  3  3  2  3  2  3  3  3                                             |     57  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 4| 7| 4| 5| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6|                                            |            |
                                           | 6| 0| 1| 6| 8| 6| 8| 4| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.0                                    | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/M3                                  | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Proteinosis                | 4  4  4  4  4  4  2  4  4  4                                             |     56  3.7|
      Bronchus, Hyperplasia, Lymphoid      | 2                    1                                                   |     14  2.1|
      Interstitium, Infiltration Cellular  | 1  1  1  1     3     1  1  1                                             |     43  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic Active         | 1  2  1        3        1                                                |     18  2.3|
      Thrombosis                           |                                                                          |      4  1.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      3  2.0|
      Olfactory Epithelium, Atrophy        |    1                    1                                                |      9  1.1|
      Olfactory Epithelium, Mineralization,|                                                                          |            |
           Focal                           | 2                    1                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      2     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 3  3  4  4  1  4  1  4  4  4                                             |     58  3.1|
      Cortex, Infarct                      |                                                                          |      2  2.5|
      Papilla, Necrosis                    |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           | 2  4  3  2     1        2  2                                             |     35  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Calculus Micro Observation Only      |                                                                          |      3     |
      Inflammation                         |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.0                                    | 8| 8| 8| 9| 0| 2| 2| 3| 4| 4|                                            |      L     |
    LUNG TOX                               | 1| 5| 7| 3| 6| 2| 4| 1| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +                                                      |   1        |
      Ectasia                              |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +        +  +     +                                             |   5        |
      Hyperplasia, Lymphoid                |       1  1        2  1     3                                             |      5  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +  +        +  +     +                                             |   5        |
      Hyperplasia, Lymphoid                |                   1  2     3                                             |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +        +  +     +                                             |   5        |
      Inflammation, Chronic Active         |       1  3        1  2     3                                             |      5  2.0|
      Alveolus, Hyperplasia, Macrophage    |       3  4        3  3     4                                             |      5  3.4|
      Alveolus, Proteinosis                |       3  2        2  2     2                                             |      5  2.2|
      Bronchus, Hyperplasia, Lymphoid      |       1  1           1     1                                             |      4  1.0|
      Interstitium, Infiltration Cellular  |       1  2        2  2     2                                             |      5  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +        +  +     +                                             |   5        |
      Inflammation, Chronic Active         |          1        1        1                                             |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05107-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:40:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.0                                    | 8| 8| 8| 9| 0| 2| 2| 3| 4| 4|                                            |      L     |
    LUNG TOX                               | 1| 5| 7| 3| 6| 2| 4| 1| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Atrophy        |                            1                                             |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                            X                                             |      1     |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +        +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +        +  +     +                                             |   5        |
      Calculus Micro Observation Only      |       X  X        X  X     X                                             |      5     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
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