TDMS Study 05107-05 Pathology Tables
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 09/30/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|
| 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + A + + + + +|
Inflammation | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + A + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Degeneration, Cystic | 1 |
Degeneration, Fatty | 2 2 2 2 1 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Focal, Granulomatous | 1 1 2 1 2 1 1 1 |
Inflammation, Granulomatous | 1 1 |
Mixed Cell Focus | X |
Pigmentation, Hemosiderin | 3 3 |
Bile Duct, Hyperplasia | 2 2 2 1 1 2 |
Biliary Tract, Hyperplasia | 1 |
Centrilobular, Atrophy | 2 1 1 3 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 1 2 2 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 3 2 1 1 1|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|
| 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 3 2 3 1 |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + +|
Pars Distalis, Angiectasis | 4 3 3 4 2 3 3 3 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 4 2 3 4 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + M + + + + +|
C-Cell, Hyperplasia | 1 3 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Cystic | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Endometrium, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 4 2 |
Inflammation, Focal, Granulomatous | 1 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + I + + + +|
Hyperplasia, Lymphoid | 2 2 1 |
Hyperplasia, Macrophage | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + + + + + + + + + I +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|
| 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Macrophage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M + + + + M + + I + + + + + I + M + +|
Hyperplasia, Macrophage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 3 3 |
__________________________________________________________________________|
Thymus | I + + + + + + + + M + + + + M + + + + + + + + +|
Degeneration | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation | |
Tail, Hyperkeratosis | |
Tail, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Hydrocephalus | |
Cerebrum, Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + I + + +|
Hyperplasia, Squamous | 3 |
Inflammation | 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 1 1 |
Inflammation, Chronic Active | 1 2 1|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Hyperplasia, Macrophage | 1 1 1 1 1 1 1|
Alveolus, Proteinosis | 1 1 |
Interstitium, Infiltration Cellular | 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 6| 5| 4| 7| 3| 7| 5| 6| 7| 7| 6| 5| 6| 2| 2| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 4| 1| 5| 5| 7| 1| 5| 3| 6| 3| 0| 6| 3| 3| 4| 6| 6| 0| 6| 3| 1| 3| 7| 3|
| 0| 0| 7| 9| 9| 8| 3| 9| 0| 9| 1| 0| 4| 0| 0| 0| 3| 5| 0| 3| 2| 3| 1| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 1 |
Thrombosis | 1 |
Nasolacrimal Duct, Inflammation | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 3 1 4 1 1 1 4 4 1 2 4 1 1 3 3 1 2 2 2 1|
Renal Tubule, Pigmentation | 3 4 3 2 2 1 3 3 3 3 3 3 1 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|
| 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + I + + M + M I + + + + + I + M + + + M + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 3|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X |
Degeneration, Cystic | |
Degeneration, Fatty | 3 1 3 1 1 1 2 3 3|
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 1 1 1 3 1 1 1 3 2 1 1 |
Inflammation, Granulomatous | |
Mixed Cell Focus | X |
Pigmentation, Hemosiderin | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 2 3 2 |
Biliary Tract, Hyperplasia | |
Centrilobular, Atrophy | 1 1 3 3 2 |
Hepatocyte, Hyperplasia | 3 3 2 3 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|
| 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 4 |
Hyperplasia, Focal | 1 |
Vacuolization Cytoplasmic | 2 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 2 3 2 4 3 4 4 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 4 2 3 2 4 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Endometrium, Hyperplasia, Cystic | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | |
Inflammation, Focal, Granulomatous | 1 |
__________________________________________________________________________|
Lymph Node | + |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 1 2 3 1 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + I + + + I + + + + + + M + M + + + M + + + +|
Hyperplasia, Lymphoid | 2 1 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|
| 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + I + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation | 2 |
Tail, Hyperkeratosis | 3 |
Tail, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Hydrocephalus | 2 |
Cerebrum, Compression | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Inflammation, Chronic Active | 2 1 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolus, Hyperplasia, Macrophage | 1 1 |
Alveolus, Proteinosis | |
Interstitium, Infiltration Cellular | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 2| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 3| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 0| 3| 2| 3| 3| 1| 3| 3| 7| 3| 3| 4| 6| 3| 2| 5| 7| 2| 9|
| 0| 0| 5| 0| 0| 1| 0| 1| 9| 8| 2| 6| 1| 1| 7| 2| 2| 2| 7| 0| 9| 7| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 8| 9| 0| 1| 2| 3| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 3 1 |
Thrombosis | 1 |
Nasolacrimal Duct, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 3 1 2 3 1 3 3 4 1 4 4 3 4 3 3 3 2 4 4 4 2 1 2 3|
Renal Tubule, Pigmentation | 2 2 3 4 3 3 3 3 4 2 2 3 2 3 3 3 2 4 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 4| 7| 4| 4| 7| | |
DAY ON TEST | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3| | |
| 9| 9| 4| 9| 1| 7| 1| 9| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 7| 9| 0| 1| 3| 4| 5| 6| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + | 54 |
Inflammation | | 1 2.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 55 |
Hyperplasia, Lymphoid | | 3 2.7|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X | 47 |
Degeneration, Cystic | | 1 1.0|
Degeneration, Fatty | 2 | 16 1.9|
Eosinophilic Focus | | 3 |
Hepatodiaphragmatic Nodule | X | 7 |
Inflammation, Focal, Granulomatous | 2 1 1 1 | 24 1.3|
Inflammation, Granulomatous | 1 1 | 4 1.0|
Mixed Cell Focus | X | 3 |
Pigmentation, Hemosiderin | | 3 2.7|
Bile Duct, Hyperplasia | 1 1 | 18 1.5|
Biliary Tract, Hyperplasia | | 1 1.0|
Centrilobular, Atrophy | | 9 1.9|
Hepatocyte, Hyperplasia | | 4 2.8|
Hepatocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | | 10 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperplasia, Squamous | 3 | 2 3.0|
Inflammation | | 1 2.0|
Ulcer | 4 | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 4| 7| 4| 4| 7| | |
DAY ON TEST | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3| | |
| 9| 9| 4| 9| 1| 7| 1| 9| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 7| 9| 0| 1| 3| 4| 5| 6| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 1 1 1 | 25 1.1|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Degeneration, Cystic | 2 | 11 2.1|
Hyperplasia, Focal | | 1 1.0|
Vacuolization Cytoplasmic | 3 | 4 2.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 52 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Angiectasis | 2 2 3 | 21 3.0|
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | 2 | 13 2.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 56 |
C-Cell, Hyperplasia | 1 1 | 16 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Hyperplasia, Cystic | 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Cyst | X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 58 |
Cyst | | 1 |
Endometrium, Hyperplasia, Cystic | | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Atrophy | 2 | 2 2.0|
Fibrosis | | 2 3.0|
Inflammation, Focal, Granulomatous | 1 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 4| 7| 4| 4| 7| | |
DAY ON TEST | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3| | |
| 9| 9| 4| 9| 1| 7| 1| 9| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 7| 9| 0| 1| 3| 4| 5| 6| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | | 11 1.8|
Hyperplasia, Macrophage | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + | 49 |
Hyperplasia, Lymphoid | | 3 1.7|
Hyperplasia, Plasma Cell | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 3 1.7|
Hyperplasia, Macrophage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + | 51 |
Hyperplasia, Macrophage | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Fibrosis | | 2 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation, Hemosiderin | 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 54 |
Degeneration | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Hyperplasia, Cystic | | 11 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Hyperkeratosis | | 1 2.0|
Inflammation | | 1 2.0|
Tail, Hyperkeratosis | | 1 3.0|
Tail, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
Hyperostosis | X | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Cyst | X | 1 |
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 4| 7| 4| 4| 7| | |
DAY ON TEST | 2| 2| 7| 5| 2| 7| 3| 5| 7| 3| | |
| 9| 9| 4| 9| 1| 7| 1| 9| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 7| 9| 0| 1| 3| 4| 5| 6| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Cerebrum, Compression | X | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 57 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation | | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Hemorrhage, Acute | | 2 1.0|
Inflammation, Chronic Active | 1 | 7 1.3|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 2 2.0|
Alveolus, Hyperplasia, Macrophage | | 9 1.0|
Alveolus, Proteinosis | | 2 1.0|
Interstitium, Infiltration Cellular | 2 2 1 1 1 1 | 28 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Chronic Active | 1 | 9 1.6|
Thrombosis | | 2 1.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.5|
Retina, Degeneration | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Cyst | | 1 |
Nephropathy | 3 3 1 4 2 4 1 4 | 52 2.5|
Renal Tubule, Pigmentation | 4 3 2 2 3 | 40 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 7| 8| 0| 0| 0| 1| 2| 3| 3| 3| | L |
LUNG TOX | 9| 8| 4| 6| 8| 2| 8| 2| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Metaplasia, Osseous | 1 | 1 1.0|
Interstitium, Infiltration Cellular | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation, Chronic Active | 1 | 1 1.0|
Olfactory Epithelium, Erosion, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 7| 8| 0| 0| 0| 1| 2| 3| 3| 3| | L |
LUNG TOX | 9| 8| 4| 6| 8| 2| 8| 2| 7| 8| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|
| 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/M3 | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M M + M + + + + + I + + + + M + M + + + + + M +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 3 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Degeneration, Fatty | 1 1 4 3 3 |
Eosinophilic Focus | X|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 2 1 1 2 1 1 1 1 |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 1 |
Centrilobular, Atrophy | 1 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 4 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 1 1 1 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 4 2 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|
| 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/M3 | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 1 3 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 2 2 2 2 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 3 |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + + I + + + + +|
Hemorrhage, Acute | |
Hyperplasia, Lymphoid | 4 2 1 2 2 2 2 2 3 2 2 2 1 2 3 1 1 2 2|
Hyperplasia, Macrophage | 1 1 1 2 1 2 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 2 |
Hyperplasia, Plasma Cell | 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|
| 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/M3 | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 |
Hyperplasia, Macrophage | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Cystic | 2 1 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Tail, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Cerebrum, Compression | X X X X |
__________________________________________________________________________|
Spinal Cord | |
Degeneration, Secondary Wallerian | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 2 2 2 2 2 1 2 2 1 1 1 2 2 3 2 1 1 1 2 2 2|
Hemorrhage, Acute | 2 |
Inflammation, Chronic Active | 3 3 3 3 3 2 3 2 3 2 2 2 2 2 2 2 3 3 2 3 2 3 4 3|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 2 3 2 2 |
Alveolus, Hyperplasia, Macrophage | 3 3 2 3 3 2 3 2 3 3 2 3 2 3 1 3 2 3 3 3 3 3 3|
Alveolus, Proteinosis | 3 3 2 2 3 1 1 2 2 2 1 2 1 1 2 2 3 1 3 2 1 1|
Bronchus, Hyperplasia, Lymphoid | 1 2 2 1 2 2 1 2 2 |
Interstitium, Infiltration Cellular | 1 3 1 2 2 2 2 2 1 2 1 1 2 1 2 2 1 2 3|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 2| 5| 2| 2| 2| 2| 8| 3| 2| 3| 8| 2| 0| 3| 9| 9| 3| 5| 2| 2| 3| 3| 2| 1|
| 0| 9| 9| 2| 9| 1| 9| 2| 2| 9| 2| 2| 9| 9| 0| 9| 0| 0| 3| 9| 9| 1| 8| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/M3 | 1| 2| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 3 |
Nasolacrimal Duct, Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 3 1 2 4 3 2 2 2 2 2 1 2 1 2 1 2 4 2 3 4 4 1 1 1|
Renal Tubule, Pigmentation | 2 2 2 3 4 1 4 2 1 2 2 4 4 3 1 4 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|
| 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + A + + M + + + M + + + + + M + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 1 1 |
Degeneration, Fatty | 1 3 2 2 1|
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 1 1 1 2 1 1 1 1 1|
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 1 1 2 |
Centrilobular, Atrophy | 3 2 3 |
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|
| 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia | 4 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Angiectasis | 3 2 3 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 3 |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 1 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 2 1 2 2 1 2 2 2|
Hyperplasia, Macrophage | 1 1 1 1 1 1 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|
| 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | 2 1 1 2 |
Hyperplasia, Macrophage | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 3 2 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia, Cystic | 2 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Tail, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Cerebrum, Compression | X X X X|
__________________________________________________________________________|
Spinal Cord | |
Degeneration, Secondary Wallerian | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 1 1 3 1 1 2 1 2 2 2 2 2 2 1 2 2|
Hemorrhage, Acute | 1 1 |
Inflammation, Chronic Active | 2 2 2 3 2 2 3 2 2 3 2 3 2 2 3 3 2 2 3 2 3 2|
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 |
Alveolus, Hyperplasia, Macrophage | 3 2 3 2 3 2 2 3 3 3 2 1 2 2 2 2 2 2 3 2 2 3 2|
Alveolus, Proteinosis | 2 2 4 2 2 2 1 2 2 2 1 2 3 2 1 1 2 2 2 2 3 3|
Bronchus, Hyperplasia, Lymphoid | 1 1 1 1 1|
Interstitium, Infiltration Cellular | 1 1 1 1 1 1 1 1 1 3 1 1 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 4| 7| 4| 4| 4| 7| 2| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 3| 2| 5| 0| 5| 5| 5| 2| 0| 2| 3| 4| 3| 4| 2| 3| 9| 2| 3| 3| 3| 9|
| 0| 6| 9| 1| 7| 2| 6| 9| 9| 9| 9| 0| 9| 1| 2| 1| 0| 9| 1| 4| 0| 0| 2| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 3| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 1 1 1 1 2 |
Nasolacrimal Duct, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 2 2 |
Olfactory Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 1 2 2 2 4 2 1 4 2 4 3 3 2 2 4 1 3|
Renal Tubule, Pigmentation | 2 2 2 3 2 1 2 3 3 2 2 3 2 3 4 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 4| 5| 7| 6| 7| | |
DAY ON TEST | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3| | |
| 1| 9| 8| 0| 6| 9| 4| 8| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + M + M | 43 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 5 2.6|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Basophilic Focus | X X X X X X X X X | 49 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 1 | 4 1.0|
Degeneration, Fatty | 4 4 | 12 2.4|
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Focal, Granulomatous | 1 1 1 | 22 1.1|
Inflammation, Granulomatous | | 2 1.0|
Mixed Cell Focus | | 1 |
Pigmentation, Hemosiderin | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 | 13 1.2|
Centrilobular, Atrophy | 3 | 5 2.4|
Hepatocyte, Hyperplasia | | 1 3.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 57 |
Atrophy | 2 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperplasia, Squamous | 3 | 5 2.8|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 1 1 1 | 17 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 4| 5| 7| 6| 7| | |
DAY ON TEST | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3| | |
| 1| 9| 8| 0| 6| 9| 4| 8| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Degeneration, Cystic | 4 2 | 11 2.6|
Vacuolization Cytoplasmic | | 3 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + | 56 |
Hyperplasia | 2 1 | 11 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 55 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Cyst | | 1 |
Pars Distalis, Angiectasis | 3 | 11 2.3|
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | 4 | 5 3.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
C-Cell, Hyperplasia | 1 | 12 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Hyperplasia, Cystic | | 5 3.4|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 58 |
Endometrium, Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Erythroid Cell, Hyperplasia | | 1 2.0|
Myeloid Cell, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 4| 5| 7| 6| 7| | |
DAY ON TEST | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3| | |
| 1| 9| 8| 0| 6| 9| 4| 8| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M M + | 54 |
Hemorrhage, Acute | | 1 1.0|
Hyperplasia, Lymphoid | 1 2 2 | 37 1.9|
Hyperplasia, Macrophage | 1 | 18 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + I + | 53 |
Hyperplasia, Lymphoid | | 5 2.4|
Hyperplasia, Plasma Cell | 3 | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 5 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + I + | 55 |
Hyperplasia, Lymphoid | 2 | 11 1.8|
Hyperplasia, Macrophage | | 5 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 3 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | 3 2 2 | 12 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Fibrosis | | 1 2.0|
Hyperplasia, Cystic | 2 2 3 2 2 2 | 14 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Ulcer | | 1 4.0|
Tail, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
Hyperostosis | | 3 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Hydrocephalus | | 1 2.0|
Cerebrum, Compression | X X | 10 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration, Secondary Wallerian | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 4| 5| 7| 6| 7| | |
DAY ON TEST | 8| 0| 7| 2| 6| 5| 9| 1| 3| 3| | |
| 1| 9| 8| 0| 6| 9| 4| 8| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
Inflammation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Fibrosis | 3 2 1 2 2 2 2 1 2 | 50 1.7|
Hemorrhage, Acute | | 3 1.3|
Inflammation, Chronic Active | 2 2 2 2 3 2 3 3 2 2 | 56 2.4|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 10 2.1|
Alveolus, Hyperplasia, Macrophage | 3 2 4 2 2 3 3 3 2 3 | 56 2.5|
Alveolus, Proteinosis | 3 3 2 1 3 2 3 2 3 2 | 54 2.0|
Bronchus, Hyperplasia, Lymphoid | 1 | 15 1.4|
Interstitium, Infiltration Cellular | 1 1 1 2 1 1 | 40 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Chronic Active | | 11 1.5|
Nasolacrimal Duct, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation | | 2 2.0|
Olfactory Epithelium, Metaplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 3 | 2 3.0|
Retina, Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Nephropathy | 4 4 1 1 2 4 1 4 | 54 2.3|
Renal Tubule, Pigmentation | 3 2 2 2 2 3 3 | 43 2.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 1| 1| 1| 1| 2| 5| 6| 6| 6| 7| | L |
LUNG TOX | 3| 4| 5| 7| 4| 9| 1| 4| 6| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M | 4 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation, Chronic Active | 1 1 1 1 2 | 5 1.2|
Alveolus, Hyperplasia, Macrophage | 2 2 2 2 2 | 5 2.0|
Alveolus, Proteinosis | 1 1 | 2 1.0|
Bronchus, Hyperplasia, Lymphoid | 1 | 1 1.0|
Interstitium, Infiltration Cellular | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation, Chronic Active | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 1| 1| 1| 1| 2| 5| 6| 6| 6| 7| | L |
LUNG TOX | 3| 4| 5| 7| 4| 9| 1| 4| 6| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Erosion, Focal | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|
| 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + M + + + + + M + M + + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Degeneration, Cystic | |
Degeneration, Fatty | 3 1 1 1 3 |
Eosinophilic Focus | X X |
Granuloma | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 |
Inflammation, Granulomatous | 2 1 |
Mixed Cell Focus | X |
Pigmentation, Hemosiderin | 2 2 2 |
Regeneration | 1 4|
Bile Duct, Hyperplasia | 2 2 1 1|
Centrilobular, Atrophy | 2 2 2 3 2 2 2 1|
Hepatocyte, Atrophy | 3 |
Hepatocyte, Hyperplasia | 2 |
Vein, Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|
| 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 2 2 2 3 2 |
Hyperplasia, Focal | 3 2 3 |
Hyperplasia | 3 3 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + M +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 2 3 4 2 4 |
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X |
Inflammation | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Focal, Granulomatous | 4|
Necrosis | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + +|
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Macrophage | 2|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 2 3 2 1 3 2 2 2 2 4 4 3 2 3 3 2 3 4 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|
| 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Macrophage | 1 1 2 1 1 1 1 1 1 1 1 |
Hyperplasia, Plasma Cell | |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | 2 3|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 4 3 2 |
Hyperplasia, Macrophage | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 1 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X |
Cranium, Hyperostosis | 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 2 |
Cerebrum, Compression | X X X X X |
Gray Matter, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + I + + + + + + I + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Emphysema | |
Fibrosis | 1 1 2 1 2 3 1 1 2 2 1 1 2 2 2|
Hemorrhage, Acute | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 6| 7| 2| 6| 4| 7| 7| 6| 7| 6| 2| 4| 6| 7| 6| 7| 7| 6| 5| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 7| 3| 0| 4| 5| 3| 2| 4| 3| 3| 0| 5| 0| 2| 3| 3| 2| 1| 9| 3| 3| 3| 4| 3| 6|
| 3| 2| 0| 3| 9| 1| 9| 1| 1| 5| 0| 9| 2| 6| 3| 2| 9| 5| 0| 8| 0| 0| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 2 2 1 2 3 2 2 4 1 1 2 2 3 2 1 2 2 3 2 2 1 2|
Metaplasia, Squamous | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 1 3 1 1 1 2 |
Alveolus, Hyperplasia, Macrophage | 3 3 2 3 3 3 2 3 3 3 3 3 3 3 2 2 2 4 3 3 3 2 1|
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 4 4 2 3 4|
Bronchus, Hyperplasia, Lymphoid | 1 3 2 1 2 1 2 1 |
Interstitium, Infiltration Cellular | 1 3 1 2 2 2 2 2 1 1 2 2 2 2 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 4 2 4 1 1 |
Thrombosis | 1 |
Nasolacrimal Duct, Inflammation | 3 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1|
Olfactory Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
__________________________________________________________________________|
Lacrimal Gland | + |
Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy | 2 3 2 1 3 1 4 1 1 2 4 2 4 4 2 2 4 3 1 1 1|
Renal Tubule, Pigmentation | 3 4 4 3 2 2 2 2 2 1 2 4 3 3 2 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|
| 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
1.0 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
MG/M3 | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + M + + M + + M M + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Degeneration, Cystic | 1 |
Degeneration, Fatty | 1 2 1 1 2 |
Eosinophilic Focus | X X |
Granuloma | 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 1 2 1 1 1 |
Inflammation, Granulomatous | 1 1 1|
Mixed Cell Focus | |
Pigmentation, Hemosiderin | 2 2 2 |
Regeneration | |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 |
Centrilobular, Atrophy | 2 2 2 |
Hepatocyte, Atrophy | |
Hepatocyte, Hyperplasia | |
Vein, Thrombosis | |
__________________________________________________________________________|
Mesentery | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|
| 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
1.0 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
MG/M3 | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 4 2 2 3 2 3 4 |
Hyperplasia, Focal | |
Hyperplasia | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia | 2 2 3 3 3 2 4 4 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X X |
Inflammation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Endometrium, Hyperplasia, Cystic | 4 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 3 |
Inflammation, Focal, Granulomatous | |
Necrosis | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 3 2 2 2 3 2 3 2 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|
| 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
1.0 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
MG/M3 | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Macrophage | 2 1 1 1 1 1 2 2 2 2 1 1 1 1 1|
Hyperplasia, Plasma Cell | 3 3 |
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + I + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 2 |
Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + + M + + I + + M + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 3 2 2 3 3 3 2 2 |
Hyperplasia, Macrophage | 2 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Pigmentation, Hemosiderin | 3 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X X |
Cranium, Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Cerebrum, Compression | |
Gray Matter, Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Emphysema | |
Fibrosis | 2 1 3 1 1 2 2 2 2 2 1 1 1 3 1 2 4 2 3 4 2 |
Hemorrhage, Acute | 1 1 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 2| 0| 3| 2| 3| 5| 3| 2| 2| 3| 0| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 4| 5| 5|
| 1| 9| 6| 1| 9| 0| 9| 1| 9| 2| 1| 1| 4| 0| 2| 6| 0| 0| 0| 9| 1| 0| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
1.0 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
MG/M3 | 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 2 3 1 2 2 2 3 2 3 3 3 2 3 3 2 3 3 1 2 4 3 2 1 1|
Metaplasia, Squamous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 |
Alveolus, Hyperplasia, Macrophage | 3 3 3 3 3 2 2 3 3 3 3 2 3 3 3 3 3 2 3 2 3 3 2 3 2|
Alveolus, Proteinosis | 4 4 2 4 4 4 4 4 4 2 4 1 4 4 4 2 4 4 4 4 4 4 4 4 4|
Bronchus, Hyperplasia, Lymphoid | 2 2 3 2 2 1 2 2 |
Interstitium, Infiltration Cellular | 2 2 2 2 2 1 2 2 1 2 1 1 1 1 1 1 1 2 1 1 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 1 2 3 2 1 1 1 2 1|
Thrombosis | |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 3|
__________________________________________________________________________|
Lacrimal Gland | |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy | 4 2 2 2 2 2 4 3 3 4 4 3 1 4 4 1 1 2 1 1 1 |
Renal Tubule, Pigmentation | 2 4 3 4 1 2 2 3 2 4 2 3 3 1 1 3 3 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 5| 5| 5| 7| | |
DAY ON TEST | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2| | |
| 1| 1| 9| 9| 1| 1| 3| 4| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
MG/M3 | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + I M + M + M M | 42 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Basophilic Focus | X X X X X X X X | 45 |
Degeneration, Cystic | 1 | 2 1.0|
Degeneration, Fatty | 2 | 11 1.6|
Eosinophilic Focus | X | 5 |
Granuloma | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Focal, Granulomatous | 2 | 13 1.2|
Inflammation, Granulomatous | | 5 1.2|
Mixed Cell Focus | | 1 |
Pigmentation, Hemosiderin | 3 | 7 2.1|
Regeneration | | 2 2.5|
Bile Duct, Hyperplasia | 1 2 | 14 1.3|
Centrilobular, Atrophy | 1 2 3 | 14 2.0|
Hepatocyte, Atrophy | | 1 3.0|
Hepatocyte, Hyperplasia | | 1 2.0|
Vein, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | 2 2 3 3 3 | 14 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperplasia, Squamous | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 5| 5| 5| 7| | |
DAY ON TEST | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2| | |
| 1| 1| 9| 9| 1| 1| 3| 4| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
MG/M3 | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 1 1 1 1 | 18 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Degeneration, Cystic | 2 3 2 3 3 | 19 2.6|
Hyperplasia, Focal | 2 2 | 5 2.4|
Hyperplasia | | 2 3.0|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | 3 | 6 2.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | 3 2 2 2 | 16 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 54 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 3 | 16 3.0|
Pars Distalis, Hyperplasia | 2 1 | 14 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + I + + + + + + + + | 57 |
C-Cell, Hyperplasia | 4 3 | 12 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 57 |
Hyperplasia, Cystic | 4 2 3 | 5 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Atrophy | | 1 4.0|
Cyst | X X | 6 |
Inflammation | | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 58 |
Inflammation | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 5| 5| 5| 7| | |
DAY ON TEST | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2| | |
| 1| 1| 9| 9| 1| 1| 3| 4| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
MG/M3 | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Fibrosis | 2 | 3 2.0|
Inflammation, Focal, Granulomatous | | 1 4.0|
Necrosis | 4 | 1 4.0|
Myeloid Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | 3 2 2 2 3 | 38 2.5|
Hyperplasia, Macrophage | 1 2 | 28 1.3|
Hyperplasia, Plasma Cell | | 2 3.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 56 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 2 | 6 2.3|
Hyperplasia, Macrophage | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 52 |
Hyperplasia, Lymphoid | 2 3 2 2 2 | 21 2.5|
Hyperplasia, Macrophage | | 7 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Fibrosis | 3 3 | 2 3.0|
Hematopoietic Cell Proliferation | 3 | 3 2.7|
Pigmentation, Hemosiderin | | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Hyperplasia, Cystic | 3 2 2 | 16 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Inflammation | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
Hyperostosis | | 7 |
Cranium, Hyperostosis | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 5| 5| 5| 7| | |
DAY ON TEST | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2| | |
| 1| 1| 9| 9| 1| 1| 3| 4| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
MG/M3 | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Hydrocephalus | | 2 2.0|
Cerebrum, Compression | | 5 |
Gray Matter, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 56 |
Inflammation | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Cyst | | 1 1.0|
Emphysema | 2 | 1 2.0|
Fibrosis | 2 2 1 2 2 2 2 3 | 44 1.9|
Hemorrhage, Acute | | 2 1.0|
Inflammation, Chronic Active | 3 2 1 2 3 3 3 4 | 56 2.2|
Metaplasia, Squamous | | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 11 1.6|
Alveolus, Hyperplasia, Macrophage | 2 2 3 3 2 3 3 3 4 | 57 2.7|
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 3 3 | 58 3.7|
Bronchus, Hyperplasia, Lymphoid | 2 2 2 | 19 1.8|
Interstitium, Infiltration Cellular | 1 1 1 1 1 2 1 2 2 | 48 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 57 |
Inflammation, Chronic Active | 1 1 4 3 | 22 2.0|
Thrombosis | | 1 1.0|
Nasolacrimal Duct, Inflammation | 3 | 2 3.0|
Olfactory Epithelium, Atrophy | 1 1 | 17 1.0|
Olfactory Epithelium, Metaplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.5|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 5| 5| 5| 7| | |
DAY ON TEST | 3| 8| 2| 2| 3| 3| 6| 9| 8| 2| | |
| 1| 1| 9| 9| 1| 1| 3| 4| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
MG/M3 | 7| 8| 9| 1| 2| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | 3 | 1 3.0|
Nephropathy | 2 1 2 3 4 1 1 3 1 3 | 52 2.3|
Renal Tubule, Pigmentation | 3 2 2 4 2 2 4 4 3 | 43 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | A |
1.0 | 5| 6| 7| 9| 9| 9| 1| 1| 1| 2| | L |
LUNG TOX | 9| 6| 9| 1| 6| 7| 0| 3| 4| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 4 2 2 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 4 2 2 2 2 | 5 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation, Chronic Active | 2 1 1 1 1 | 5 1.2|
Alveolus, Hyperplasia, Macrophage | 4 2 2 2 3 | 5 2.6|
Alveolus, Proteinosis | 3 3 4 4 4 | 5 3.6|
Bronchus, Hyperplasia, Lymphoid | 1 1 1 1 | 4 1.0|
Interstitium, Infiltration Cellular | 1 1 2 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation, Chronic Active | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | A |
1.0 | 5| 6| 7| 9| 9| 9| 1| 1| 1| 2| | L |
LUNG TOX | 9| 6| 9| 1| 6| 7| 0| 3| 4| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|
| 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation | 2 |
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation | 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation | 2 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 1 2 2 1 1 2 1 1 |
Degeneration, Fatty | 4 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | |
Bile Duct, Hyperplasia | 1 4 1 1 3 3 3 3 3 2 1 4 3 2 2 2 2|
Biliary Tract, Hyperplasia | |
Centrilobular, Atrophy | 3 2 2 2 |
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Necrosis | 2 4 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 2 3 3 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Hyperplasia, Squamous | 3 |
Mineralization | |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 3 |
Epithelium, Mineralization | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|
| 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 1 2 2 2 2 1 3 1 1 1 2 |
Embolus | 4 |
Inflammation | 3 3 |
Mineralization | |
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 |
Necrosis | 1 |
Vacuolization Cytoplasmic | 3 2 2 2 2 2 1 4 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 1 2 4 4 2 3 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + I + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 4 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 |
Follicle, Hyperplasia | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Concretion | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|
| 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ectasia | 3 3 |
Hyperplasia | |
Inflammation | 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 3 |
Interstitial Cell, Hyperplasia | 1 1 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Fibrosis | 3 |
Inflammation, Focal, Granulomatous | |
Necrosis | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | 1 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 3 |
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Hyperplasia, Lymphoid | |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + I + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Fibrosis | 3 3 3 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + I + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 3 3 3 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|
| 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Conjunctiva, Inflammation | |
Dermis, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Embolus | 1 |
Necrosis | |
Cerebrum, Compression | X X X |
Gray Matter, Necrosis | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + I I + + + + + + + + I + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | 2 |
Fibrosis | 2 |
Hemorrhage, Acute | 1 |
Inflammation, Chronic Active | 1 1 1 1 |
Metaplasia, Osseous | 1 1 |
Mineralization | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 |
Alveolus, Hyperplasia, Macrophage | 1 1 1 1 1 1 1 |
Alveolus, Proteinosis | |
Interstitium, Infiltration Cellular | 2 1 1 1 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 3 3|
Thrombosis | 4 |
Olfactory Epithelium, Atrophy | 1 1 |
Olfactory Epithelium, Mineralization,| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 3| 6| 4| 7| 5| 5| 5| 7| 4| 5| 6| 7| 5| 7| 6| 6| 6| 3| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 6| 0| 5| 3| 7| 9| 6| 3| 5| 5| 9| 3| 7| 3| 2| 6| 9| 7| 3| 0| 1| 3| 5| 5| 8|
| 1| 8| 8| 6| 8| 4| 5| 3| 8| 9| 6| 7| 3| 6| 4| 4| 1| 3| 6| 6| 5| 3| 8| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Inflammation | 4 |
Phthisis Bulbi | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Embolus | 2 |
Infarct | 4 |
Inflammation | 3 |
Mineralization | |
Nephropathy | 1 3 1 4 4 3 1 4 1 2 3 4 1 4 2 2 4 1 4 4 2 4 1 2 4|
Renal Tubule, Pigmentation | 3 3 2 3 3 3 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X X |
Calculus Micro Observation Only | X X |
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|
| 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation | 2 |
Mineralization | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | M I + + M + + + + + A + + + + + + + + + + M +|
Inflammation | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 4 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 1 |
Degeneration, Fatty | 4 2 4 2 1 3 3 |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | |
Inflammation, Focal, Granulomatous | 1 |
Bile Duct, Hyperplasia | 3 1 3 1 2 3 1 1 1 1 2 4 1 3 2 2 1|
Biliary Tract, Hyperplasia | 4 |
Centrilobular, Atrophy | 2 2 3 3 3 1 1|
Hepatocyte, Hyperplasia | 1 |
Hepatocyte, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
Mineralization | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
Epithelium, Mineralization | 4 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|
| 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 3 2 2 2 3 1 2 2 2 2 2 2 |
Embolus | |
Inflammation | |
Mineralization | 4 |
Atrium, Thrombosis | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia, Diffuse | 3 |
Hyperplasia, Focal | 3 |
Necrosis | |
Vacuolization Cytoplasmic | 4 3 3 2 3 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 3 4 3 3 1 1 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
Follicle, Hyperplasia | 4 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + +|
Inflammation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Concretion | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|
| 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ectasia | |
Hyperplasia | 3 |
Inflammation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 4 3 |
Interstitial Cell, Hyperplasia | 3 3 1 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Fibrosis | 4 |
Inflammation, Focal, Granulomatous | 1 |
Necrosis | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Renal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 2 2 3 |
Hyperplasia, Macrophage | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 |
Hyperplasia, Plasma Cell | 4 2 3 |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | |
Hyperplasia, Lymphoid | 3 3 2 3 1 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + I + + + M + + + + +|
Angiectasis | 4 |
Hyperplasia, Lymphoid | 3 |
Inflammation | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Fibrosis | 3 4 4 3 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + +|
Degeneration | 4 3 3 2 3 4 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|
| 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + I + + M M + + + + + + + + + + + M + + + + +|
Hyperplasia, Cystic | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Conjunctiva, Inflammation | |
Dermis, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Embolus | |
Necrosis | |
Cerebrum, Compression | X |
Gray Matter, Necrosis | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | I + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
Inflammation | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | |
Fibrosis | 2 |
Hemorrhage, Acute | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 2 1 3 |
Metaplasia, Osseous | |
Mineralization | 4 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Hyperplasia, Macrophage | 1 1 2 |
Alveolus, Proteinosis | 1 |
Interstitium, Infiltration Cellular | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 2 1 |
Thrombosis | 1 2 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Mineralization,| |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 2| 1| 7| 5| 7| 5| 5| 7| 5| 7| 5| 4| 6| 1| 6| 5| 7| 6| 4| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 5| 9| 0| 5| 1| 9| 2| 1| 7| 3| 5| 5| 3| 9| 7| 4| 3| 7| 5| 3| 9| 0| 3| 7|
| 6| 7| 9| 5| 9| 5| 9| 1| 3| 4| 3| 3| 8| 4| 9| 8| 2| 3| 1| 8| 7| 9| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 3|
Inflammation | |
Phthisis Bulbi | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + +|
Cyst | |
Embolus | |
Infarct | |
Inflammation | |
Mineralization | 3 |
Nephropathy | 4 4 2 4 2 3 4 2 4 1 4 3 1 4 4 1 4 2 4 3 2|
Renal Tubule, Pigmentation | 4 2 2 4 1 3 1 4 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X X |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 5| 7| 5| 7| 5| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3| | |
| 6| 7| 9| 1| 6| 7| 6| 5| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
Inflammation | 1 | 3 1.7|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + + + + + | 51 |
Inflammation | | 1 2.0|
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation | | 2 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | 2 3 | 4 2.8|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Angiectasis | | 3 4.0|
Basophilic Focus | X X X X X X X | 29 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 1 1 | 11 1.3|
Degeneration, Fatty | 4 | 9 3.0|
Eosinophilic Focus | | 6 |
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Focal, Granulomatous | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 2 2 1 2 | 40 2.1|
Biliary Tract, Hyperplasia | | 1 4.0|
Centrilobular, Atrophy | 1 | 12 2.1|
Hepatocyte, Hyperplasia | 3 | 3 2.3|
Hepatocyte, Necrosis | 2 | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | 2 3 2 | 15 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperkeratosis | | 1 3.0|
Hyperplasia, Squamous | | 1 3.0|
Mineralization | | 1 2.0|
Ulcer | 3 4 | 4 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 5| 7| 5| 7| 5| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3| | |
| 6| 7| 9| 1| 6| 7| 6| 5| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Necrosis, Focal | | 1 3.0|
Epithelium, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 2 1 3 2 2 | 37 1.9|
Embolus | | 1 4.0|
Inflammation | | 2 3.0|
Mineralization | | 1 4.0|
Atrium, Thrombosis | | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 57 |
Degeneration, Cystic | | 2 2.5|
Hyperplasia, Diffuse | | 1 3.0|
Hyperplasia, Focal | 2 | 3 2.0|
Necrosis | 3 | 2 2.0|
Vacuolization Cytoplasmic | 3 3 3 3 3 2 | 23 2.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | 4 2 2 1 2 | 26 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 55 |
Hyperplasia | 2 2 3 | 8 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 2 4 | 4 2.8|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 4 4 | 17 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 57 |
C-Cell, Hyperplasia | 1 | 7 1.1|
Follicle, Hyperplasia | | 1 4.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 5| 7| 5| 7| 5| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3| | |
| 6| 7| 9| 1| 6| 7| 6| 5| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + | 39 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Penis | + + | 2 |
Concretion | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Ectasia | | 2 3.0|
Hyperplasia | 3 4 | 3 3.3|
Inflammation | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Inflammation | | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 57 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Germinal Epithelium, Degeneration | 3 2 | 7 3.0|
Interstitial Cell, Hyperplasia | 2 3 | 14 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Atrophy | | 4 2.5|
Fibrosis | | 2 3.5|
Inflammation, Focal, Granulomatous | | 1 1.0|
Necrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Renal, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + | 57 |
Angiectasis | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 5 2.2|
Hyperplasia, Macrophage | | 1 1.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 55 |
Hyperplasia, Lymphoid | 2 | 4 2.8|
Hyperplasia, Plasma Cell | 2 | 6 2.8|
Inflammation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 5| 7| 5| 7| 5| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3| | |
| 6| 7| 9| 1| 6| 7| 6| 5| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Angiectasis | | 1 4.0|
Atrophy | | 1 3.0|
Hyperplasia, Lymphoid | | 5 2.4|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + M + + + | 53 |
Angiectasis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Atrophy | | 3 3.3|
Fibrosis | 2 3 | 10 3.1|
Hematopoietic Cell Proliferation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + I + + + + + | 55 |
Degeneration | 3 3 3 2 | 17 3.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 53 |
Hyperplasia, Cystic | 1 1 2 2 1 | 8 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 2 |
Conjunctiva, Inflammation | 4 | 1 4.0|
Dermis, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
Fibrous Osteodystrophy | | 1 |
Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Compression | | 1 |
Embolus | | 1 1.0|
Necrosis | 4 | 1 4.0|
Cerebrum, Compression | X X | 6 |
Gray Matter, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 5| 7| 5| 7| 5| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3| | |
| 6| 7| 9| 1| 6| 7| 6| 5| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 54 |
Hyperplasia | | 4 2.0|
Inflammation | 1 | 3 1.7|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Embolus | | 1 2.0|
Fibrosis | | 2 2.0|
Hemorrhage, Acute | | 7 1.0|
Inflammation, Chronic Active | 1 | 9 1.3|
Metaplasia, Osseous | | 2 1.0|
Mineralization | | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 3.0|
Alveolus, Hyperplasia, Macrophage | | 10 1.1|
Alveolus, Proteinosis | | 1 1.0|
Interstitium, Infiltration Cellular | 1 1 1 | 19 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Chronic Active | | 13 1.8|
Thrombosis | | 3 2.3|
Olfactory Epithelium, Atrophy | | 2 1.0|
Olfactory Epithelium, Mineralization,| | |
Focal | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | | 1 3.0|
Inflammation | | 1 4.0|
Phthisis Bulbi | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 57 |
Cyst | | 1 |
Embolus | | 1 2.0|
Infarct | | 1 4.0|
Inflammation | | 1 3.0|
Mineralization | | 1 3.0|
Nephropathy | 4 4 2 4 4 4 4 4 4 3 | 56 2.9|
Renal Tubule, Pigmentation | 3 1 | 20 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 5| 7| 5| 7| 5| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 3| 6| 2| 3| | |
| 6| 7| 9| 1| 6| 7| 6| 5| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Calculus Gross Observation | | 4 |
Calculus Micro Observation Only | X | 5 |
Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 0| 1| 2| 2| 3| 5| 5| 5| 6| | L |
LUNG TOX | 1| 2| 4| 0| 4| 5| 0| 8| 9| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation, Chronic Active | 1 | 1 1.0|
Interstitium, Infiltration Cellular | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 3 |
Calculus Micro Observation Only | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|
DAY ON TEST | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|
| 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + M + + + + + + + M + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 3 1 1 2 2 2 1 1|
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | |
Bile Duct, Hyperplasia | 4 4 4 3 4 2 3 1 3 1 2 3 3 3 1 2 2 2 1|
Centrilobular, Atrophy | 2 2 2 2 2 |
Hepatocyte, Hyperplasia | 1 |
Hepatocyte, Necrosis | 4 1 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infarct | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperkeratosis | 3 3 3 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 2 |
Epithelium, Mineralization | 3 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 1 3 2 2 2 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|
DAY ON TEST | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|
| 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration, Cystic | |
Hyperplasia, Focal | 3 |
Vacuolization Cytoplasmic | 2 3 3 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 1 2 2 3 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 4 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 4 1 4 4 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + |
Inflammation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | 4 |
Inflammation | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 3 2 4 2 3 4 3|
Interstitial Cell, Hyperplasia | 1 3 3 1 2 3 2 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Inflammation, Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|
DAY ON TEST | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|
| 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | 3 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + + M + +|
Ectasia | 3 |
Hyperplasia, Lymphoid | 1 2 3 2 2 2 2 3 3 2 2 3 2 2|
Hyperplasia, Macrophage | 1 1 1 1 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2|
Hyperplasia, Plasma Cell | 3 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 2 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 1|
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | 3 3 3 3 3 2 3 4 |
Hyperplasia, Lymphoid | |
Infarct | 4 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | M + M + + + + + + + + + + + + + + + + + + + + + M|
Degeneration | 2 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + I + + + M + +|
Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Tail, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 6| 5| 6| 7| 3| 5| 5| 7| 6| 7| 5|
DAY ON TEST | 2| 3| 9| 3| 9| 3| 9| 1| 2| 3| 5| 0| 3| 3| 0| 9| 3| 3| 9| 6| 5| 3| 2| 3| 9|
| 7| 8| 5| 3| 9| 3| 0| 8| 3| 6| 8| 0| 3| 6| 8| 9| 9| 7| 8| 3| 2| 6| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Emphysema | 1 |
Fibrosis | 3 1 2 2 1 2 2 2 1 2 1 2 2 2 2 1 2 2 2 3 1 3 |
Hemorrhage, Acute | |
Inflammation, Chronic Active | 2 2 3 3 2 3 3 3 2 3 2 2 3 3 3 3 2 3 1 3 3 3 2 3 3|
Metaplasia, Osseous | 1|
Metaplasia, Squamous | 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 4 |
Alveolus, Hyperplasia, Macrophage | 2 1 3 3 3 3 2 1 3 2 3 2 1 3 2 1 3 2 3 2|
Alveolus, Proteinosis | 1 2 2 1 2 2 1 1 1 1 1 1 1 1|
Bronchus, Hyperplasia, Lymphoid | 2 2 2 2 1 |
Interstitium, Infiltration Cellular | 2 1 1 1 1 2 1 1 2 2 1 2 2 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 1 2 1 4 4 3 2|
Thrombosis | 1 |
Olfactory Epithelium, Atrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Anterior Chamber, Hemorrhage, Chronic| 3 |
Iris, Inflammation | |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Nephropathy | 4 3 3 4 2 4 3 2 3 4 1 4 4 4 3 4 3 4 1 2 2 4 2 4 3|
Renal Tubule, Pigmentation | 2 2 2 4 2 2 3 4 2 2 3 4 4 4 1 3 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|
| 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
MG/M3 | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + M + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | 2 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 1 2 1 |
Degeneration, Fatty | 3 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | |
Inflammation, Focal, Granulomatous | 1 1 |
Bile Duct, Hyperplasia | 1 2 2 2 3 1 2 3 1 2 2 2 2 1 3 1 3|
Centrilobular, Atrophy | 4 4 3 3 1 2 2 2|
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 2 2 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 2 2 3 |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 4 |
Hyperkeratosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 2 |
Epithelium, Mineralization | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 2 1 1 2 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|
| 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
MG/M3 | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration, Cystic | 2 2 |
Hyperplasia, Focal | 3 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 4 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + +|
Inflammation | 3 3|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia | |
Inflammation | 3 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 3 4 3|
Interstitial Cell, Hyperplasia | 2 1 3 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Focal, Granulomatous | 1 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|
| 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
MG/M3 | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 2 1 1 1 2 1 2 3 3 2 1 2 3 2 2 |
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 2 1 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 4 |
Hyperplasia, Plasma Cell | 3 4 3 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 4 2 2 3 2 2 2 |
Hyperplasia, Macrophage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 3 3 4 3 |
Hyperplasia, Lymphoid | 2 3 2 |
Infarct | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Tail, Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | X|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 5| 1| 5| 5| 5| 4| 6| 4| 7| 7| 7| 4| 6| 4| 6| 4| 1| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 9| 6| 3| 5| 2| 5| 3| 3| 3| 5| 5| 5| 3| 5| 9| 0| 3| 3| 3| 3| 3| 4|
| 3| 9| 9| 5| 9| 8| 8| 4| 8| 6| 6| 6| 8| 0| 8| 9| 5| 9| 1| 3| 3| 6| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
MG/M3 | 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Emphysema | |
Fibrosis | 2 4 1 1 2 2 1 1 2 1 2 2 2 1 2 1 1|
Hemorrhage, Acute | 1 |
Inflammation, Chronic Active | 3 2 2 2 3 1 3 1 3 3 2 2 3 1 2 1 3 3 2 2 3 1 2|
Metaplasia, Osseous | 1 |
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 |
Alveolus, Hyperplasia, Macrophage | 3 3 2 2 3 2 3 2 3 3 2 2 3 2 3 2 2 3 2 2 3 2 2|
Alveolus, Proteinosis | 1 1 1 1 1 2 1 1 1 2 2 2 2 1 2 1 1 1 1 2|
Bronchus, Hyperplasia, Lymphoid | 1 2 2 1 |
Interstitium, Infiltration Cellular | 1 2 2 3 1 1 1 1 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 4 2|
Thrombosis | 1 1 |
Olfactory Epithelium, Atrophy | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 4 |
Anterior Chamber, Hemorrhage, Chronic| |
Iris, Inflammation | |
Retina, Degeneration | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 4 3 2 2 1 1 2 1 4 4 4 1 4 1 4 1 4 4 4 4 2 4 3|
Renal Tubule, Pigmentation | 2 3 4 2 4 1 2 2 1 4 1 2|
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| | |
DAY ON TEST | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3| | |
| 3| 1| 6| 3| 7| 3| 4| 0| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + M M + + | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + | 54 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 5 2.8|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X | 35 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 1 1 1 1 | 15 1.4|
Degeneration, Fatty | | 2 2.5|
Eosinophilic Focus | | 6 |
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Focal, Granulomatous | | 2 1.0|
Bile Duct, Hyperplasia | 4 3 3 2 3 1 2 2 1 | 45 2.3|
Centrilobular, Atrophy | 2 2 3 | 16 2.4|
Hepatocyte, Hyperplasia | | 1 1.0|
Hepatocyte, Necrosis | 1 | 7 2.1|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | 3 3 3 3 | 15 2.4|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 57 |
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Diverticulum | | 1 4.0|
Hyperkeratosis | | 3 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Necrosis, Focal | | 2 2.0|
Epithelium, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| | |
DAY ON TEST | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3| | |
| 3| 1| 6| 3| 7| 3| 4| 0| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 1 2 1 2 1 1 1 1 | 37 1.5|
Atrium, Thrombosis | X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Atrophy | | 1 3.0|
Degeneration, Cystic | 3 | 3 2.3|
Hyperplasia, Focal | | 2 3.0|
Vacuolization Cytoplasmic | | 7 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + | 57 |
Hyperplasia | 2 2 3 | 22 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M + + | 55 |
Hyperplasia | 2 2 | 6 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Angiectasis | 2 | 9 2.8|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 1 | 12 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
C-Cell, Hyperplasia | 1 | 8 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + | 47 |
Inflammation | 2 | 3 2.7|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
Granuloma Sperm | 3 | 3 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Ectasia | | 1 3.0|
Hyperplasia | | 1 4.0|
Inflammation | 2 | 6 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Inflammation | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| | |
DAY ON TEST | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3| | |
| 3| 1| 6| 3| 7| 3| 4| 0| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
Atrophy | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Germinal Epithelium, Degeneration | 3 | 13 3.1|
Interstitial Cell, Hyperplasia | 1 | 16 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + M + | 57 |
Atrophy | | 3 2.3|
Inflammation, Focal, Granulomatous | | 1 1.0|
Necrosis | | 1 3.0|
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 16 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 56 |
Ectasia | | 1 3.0|
Hyperplasia, Lymphoid | 1 2 2 3 2 | 34 2.0|
Hyperplasia, Macrophage | 1 1 1 1 | 18 1.1|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 56 |
Hyperplasia, Lymphoid | 2 2 | 7 2.7|
Hyperplasia, Plasma Cell | 3 | 10 3.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 1 | 11 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + M + M + + | 54 |
Hyperplasia, Lymphoid | 3 | 15 2.3|
Hyperplasia, Macrophage | 1 | 2 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Atrophy | 3 | 2 3.0|
Fibrosis | 4 | 13 3.2|
Hyperplasia, Lymphoid | 3 | 4 2.5|
Infarct | 4 | 2 4.0|
Pigmentation, Hemosiderin | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 53 |
Degeneration | | 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| | |
DAY ON TEST | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3| | |
| 3| 1| 6| 3| 7| 3| 4| 0| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 1 |
Tail, Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + M + | 57 |
Hyperostosis | | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Cerebrum, Compression | X X | 4 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 57 |
Inflammation | | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Emphysema | | 1 1.0|
Fibrosis | 1 2 1 2 2 1 2 2 2 | 48 1.8|
Hemorrhage, Acute | | 1 1.0|
Inflammation, Chronic Active | 2 2 3 2 2 4 2 2 3 2 | 58 2.4|
Metaplasia, Osseous | | 2 1.0|
Metaplasia, Squamous | | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 6 2.2|
Alveolus, Hyperplasia, Macrophage | 2 3 3 2 2 3 3 3 3 2 | 53 2.4|
Alveolus, Proteinosis | 2 1 1 1 2 2 1 | 41 1.3|
Bronchus, Hyperplasia, Lymphoid | 2 | 10 1.7|
Interstitium, Infiltration Cellular | 1 1 3 1 1 2 2 1 | 35 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | 3 | 12 2.3|
Thrombosis | | 3 1.0|
Olfactory Epithelium, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| | |
DAY ON TEST | 1| 6| 3| 3| 1| 3| 9| 7| 3| 3| | |
| 3| 1| 6| 3| 7| 3| 4| 0| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.15 | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | | 2 4.0|
Anterior Chamber, Hemorrhage, Chronic| | 1 3.0|
Iris, Inflammation | 2 | 1 2.0|
Retina, Degeneration | | 3 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Cyst | | 2 |
Nephropathy | 3 3 4 4 4 4 3 2 4 4 | 58 3.0|
Renal Tubule, Pigmentation | 2 3 2 2 1 2 2 | 35 2.5|
__________________________________________________________________________|____________|
Urethra | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Calculus Gross Observation | | 2 |
Calculus Micro Observation Only | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| | A |
0.15 | 4| 5| 5| 7| 8| 8| 9| 9| 0| 0| | L |
LUNG TOX | 7| 0| 8| 6| 2| 5| 6| 8| 0| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 2 1 1 1 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation, Chronic Active | 1 1 1 1 2 | 5 1.2|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolus, Hyperplasia, Macrophage | 2 2 2 2 2 | 5 2.0|
Alveolus, Proteinosis | 1 1 1 | 3 1.0|
Bronchus, Hyperplasia, Lymphoid | 2 | 1 2.0|
Interstitium, Infiltration Cellular | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| | A |
0.15 | 4| 5| 5| 7| 8| 8| 9| 9| 0| 0| | L |
LUNG TOX | 7| 0| 8| 6| 2| 5| 6| 8| 0| 4| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 4 |
Calculus Micro Observation Only | X X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|
| 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Degeneration, Cystic | 1 2 1 1 1 2 1 2 1 |
Degeneration, Fatty | 1 |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Focal, Granulomatous | |
Pigmentation, Hemosiderin | |
Thrombosis | X |
Bile Duct, Hyperplasia | 2 2 4 1 1 1 1 2 2 4 3 3 2 2 4 3 3 3|
Centrilobular, Atrophy | 3 3|
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Necrosis | 2 2 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 1 2 3 2 2 1 2 3 1 3 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|
| 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 1 3 2 2 2 2 1 2 2 2 |
Mineralization | |
Atrium, Thrombosis | X X X |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia, Focal | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 3 2 1 2 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 3 2 |
Bilateral, Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Angiectasis | 4 3|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 3 2 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 3 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia | 4 |
Inflammation | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|
| 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 4 4 3 1 3 |
Interstitial Cell, Hyperplasia | 3 2 1 2 2 3 1 1 3 2 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | |
Granuloma | 2 |
Inflammation, Suppurative | 3|
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 3 2 2 2 2 3 3 3 3 4 3 |
Hyperplasia, Macrophage | 1 2 2 1 1 1 1 1 2 1 2 1 1 1 1 |
Hyperplasia, Plasma Cell | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + + + + + + + + + + + M + + + + + + + I|
Hyperplasia, Lymphoid | 4 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | 3 3 4 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + M + + + + M + + +|
Degeneration | 4 4 4 4 4 4 4 4 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + I + + M + + + + + + + + M +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Inflammation | |
Tail, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|
| 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Mandible, Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Cerebrum, Atrophy, Focal | |
Cerebrum, Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Emphysema | |
Fibrosis | 2 2 1 1 1 1 2 1 1 1 4 1 2|
Inflammation, Chronic Active | 3 4 3 1 3 3 1 2 1 2 2 2 3 4 2 3 2 3 3 3 2 2 3 3 2|
Metaplasia, Osseous | 1 |
Mineralization | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 3 |
Alveolus, Emphysema | 2 |
Alveolus, Hyperplasia, Macrophage | 2 2 3 2 3 3 3 4 2 2 3 3 3 4 3 3 2 3 3 3 3 3 3 3 3|
Alveolus, Proteinosis | 4 3 4 3 4 4 4 4 4 3 1 4 4 4 4 4 4 3 4 4 3 4 2|
Bronchus, Hyperplasia, Lymphoid | 2 3 2 2 |
Interstitium, Infiltration Cellular | 1 2 2 2 3 2 2 1 2 3 3 2 3 2 3 2 3 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 4 3 4 4 3 1 4|
Thrombosis | 1 |
Nasolacrimal Duct, Inflammation | 2 |
Olfactory Epithelium, Atrophy | 2 1 1 1 |
Olfactory Epithelium, Mineralization,| |
Focal | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | |
Infarct | 3 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 7| 5| 5| 7| 4| 7| 7| 7| 6| 7| 7| 5| 4| 5| 7| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 9| 4| 4| 5| 1| 9| 5| 3| 5| 3| 0| 2| 7| 0| 3| 5| 5| 2| 3| 6| 2| 3| 3| 3| 0|
| 0| 3| 8| 8| 1| 4| 2| 6| 8| 3| 3| 3| 8| 3| 6| 9| 8| 7| 6| 3| 3| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 2| 3| 4| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | |
Nephropathy | 1 3 4 1 3 2 2 4 1 4 2 3 4 2 4 4 1 2 4 2 3 3 4 4 3|
Cortex, Infarct | |
Papilla, Necrosis | |
Renal Tubule, Pigmentation | 2 2 1 3 4 3 2 3 2 3 1 4 2 2 1 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|
| 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation | 2 3 1 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X |
Degeneration, Cystic | 1 3 2 1 3 |
Degeneration, Fatty | 2 1 2 2|
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Focal, Granulomatous | 2 |
Pigmentation, Hemosiderin | |
Thrombosis | |
Bile Duct, Hyperplasia | 1 3 1 2 3 3 1 3 2 1 2 3 3 1 2 |
Centrilobular, Atrophy | 4 4 3 3 2 2 2|
Hepatocyte, Hyperplasia | 2 |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 3 3 3 2 3 3 3 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 3 3 2|
Ulcer | 3 4 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 2 2|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|
| 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 1 1 1 2 2 2 2 1 |
Mineralization | 3 |
Atrium, Thrombosis | X |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 1 |
Hyperplasia, Focal | 2 |
Necrosis | 1 |
Vacuolization Cytoplasmic | 4 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 |
Bilateral, Thrombosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia | |
Inflammation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|
| 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 2 2 3 2 2 |
Interstitial Cell, Hyperplasia | 3 2 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | 2 |
Granuloma | |
Inflammation, Suppurative | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 1 1 1 4 2 2 2 2 4 2 1 4 1 2|
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 2 1 2 1|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + M + M +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 3 4 3 3 2 3 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + + + + + + + + + + + + M M + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Subcutaneous Tissue, Inflammation | 3|
Tail, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|
| 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X |
Mandible, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cerebrum, Atrophy, Focal | |
Cerebrum, Compression | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Emphysema | 2 |
Fibrosis | 1 2 1 1 4 1 3 2 3 2 2 2 1 2 3 2 2 1 1 1|
Inflammation, Chronic Active | 3 3 2 2 3 3 4 2 3 3 3 2 2 3 4 1 4 3 2 3 2 3|
Metaplasia, Osseous | |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 3 1 2 1 2 1 |
Alveolus, Emphysema | |
Alveolus, Hyperplasia, Macrophage | 3 2 3 3 3 4 3 3 3 4 3 3 3 3 3 3 4 2 3 3 3 3|
Alveolus, Proteinosis | 4 2 4 4 3 4 4 4 4 4 4 4 3 3 4 2 4 4 4 4 4 4 4|
Bronchus, Hyperplasia, Lymphoid | 2 2 2 2 3 3 2 2 |
Interstitium, Infiltration Cellular | 2 1 1 2 3 2 3 2 2 1 2 2 2 1 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 3|
Thrombosis | 1 1 1|
Nasolacrimal Duct, Inflammation | 2 2 |
Olfactory Epithelium, Atrophy | 1 1 1|
Olfactory Epithelium, Mineralization,| |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | 3 |
Infarct | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 6| 5| 7| 7| 1| 6| 5| 6| 6| 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 2| 3| 2| 2| 7| 3| 3| 9| 5| 7| 2| 4| 9| 6| 3| 3| 1| 5| 0| 3| 3| 3| 9| 6|
| 3| 9| 3| 4| 1| 8| 6| 3| 9| 0| 7| 1| 2| 9| 3| 7| 3| 6| 8| 7| 7| 6| 7| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 2 |
Nephropathy | 4 3 4 2 3 3 4 4 2 4 3 2 4 4 4 4 1 4 4 4 4 4 3|
Cortex, Infarct | 3 2 |
Papilla, Necrosis | 4 |
Renal Tubule, Pigmentation | 1 3 2 3 3 2 2 1 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
Inflammation | 2 2 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 7| 4| 5| 7| 5| | |
DAY ON TEST | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6| | |
| 6| 0| 1| 6| 8| 6| 8| 4| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.0 | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + M | 57 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + M + + | 57 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Inflammation | 4 | 4 2.5|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + | 57 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Basophilic Focus | X X X X X X X | 35 |
Degeneration, Cystic | 1 | 15 1.5|
Degeneration, Fatty | 1 1 | 7 1.4|
Eosinophilic Focus | | 6 |
Hepatodiaphragmatic Nodule | | 4 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 1 1 1 1 2 | 39 2.1|
Centrilobular, Atrophy | 1 1 1 1 | 13 2.3|
Hepatocyte, Hyperplasia | | 2 2.5|
Hepatocyte, Necrosis | | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | 2 3 | 25 2.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperplasia, Squamous | 3 | 5 2.8|
Ulcer | 3 3 | 6 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 7| 4| 5| 7| 5| | |
DAY ON TEST | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6| | |
| 6| 0| 1| 6| 8| 6| 8| 4| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.0 | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Necrosis, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 1 1 1 1 2 2 2 | 36 1.6|
Mineralization | | 1 3.0|
Atrium, Thrombosis | | 4 |
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Degeneration, Cystic | | 5 1.6|
Hyperplasia, Focal | | 2 2.0|
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | 2 3 | 12 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | 3 2 | 11 2.3|
Bilateral, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 56 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Cyst | | 1 |
Pars Distalis, Angiectasis | | 3 3.0|
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | 4 | 13 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
C-Cell, Hyperplasia | 2 | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 7| 4| 5| 7| 5| | |
DAY ON TEST | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6| | |
| 6| 0| 1| 6| 8| 6| 8| 4| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.0 | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Ectasia | | 2 3.0|
Hyperplasia | | 1 4.0|
Inflammation | 2 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 57 |
Atrophy | | 2 3.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Germinal Epithelium, Degeneration | 3 3 | 13 2.8|
Interstitial Cell, Hyperplasia | 2 | 18 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Atrophy | | 2 2.0|
Fibrosis | | 1 2.0|
Granuloma | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Myeloid Cell, Hyperplasia | 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 6 |
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 4 3 2 2 1 2 2 1 3 | 38 2.3|
Hyperplasia, Macrophage | 1 1 1 1 1 1 | 32 1.2|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 54 |
Hyperplasia, Lymphoid | 3 | 3 2.7|
Hyperplasia, Plasma Cell | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 1 1 | 6 1.8|
Hyperplasia, Macrophage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + | 53 |
Hyperplasia, Lymphoid | 2 2 | 9 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Atrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 7| 4| 5| 7| 5| | |
DAY ON TEST | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6| | |
| 6| 0| 1| 6| 8| 6| 8| 4| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.0 | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | 3 | 12 3.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M | 53 |
Degeneration | | 10 3.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + + + + | 48 |
Hyperplasia, Cystic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 1 |
Subcutaneous Tissue, Inflammation | | 1 3.0|
Tail, Hyperkeratosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
Hyperostosis | | 1 |
Mandible, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Cyst | | 1 |
Cerebrum, Atrophy, Focal | 4 | 1 4.0|
Cerebrum, Compression | X | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + I + + + | 57 |
Inflammation | | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Emphysema | | 1 2.0|
Fibrosis | 2 2 2 2 1 1 1 | 40 1.7|
Inflammation, Chronic Active | 1 3 2 2 1 2 1 2 2 | 56 2.5|
Metaplasia, Osseous | 1 | 2 1.0|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 11 2.1|
Alveolus, Emphysema | | 1 2.0|
Alveolus, Hyperplasia, Macrophage | 3 3 3 3 2 3 2 3 3 3 | 57 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 7| 4| 5| 7| 5| | |
DAY ON TEST | 3| 6| 3| 2| 5| 3| 0| 8| 0| 6| | |
| 6| 0| 1| 6| 8| 6| 8| 4| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.0 | 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Proteinosis | 4 4 4 4 4 4 2 4 4 4 | 56 3.7|
Bronchus, Hyperplasia, Lymphoid | 2 1 | 14 2.1|
Interstitium, Infiltration Cellular | 1 1 1 1 3 1 1 1 | 43 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 57 |
Inflammation, Chronic Active | 1 2 1 3 1 | 18 2.3|
Thrombosis | | 4 1.0|
Nasolacrimal Duct, Inflammation | | 3 2.0|
Olfactory Epithelium, Atrophy | 1 1 | 9 1.1|
Olfactory Epithelium, Mineralization,| | |
Focal | 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Cyst | | 2 |
Hydronephrosis | | 1 3.0|
Infarct | | 1 3.0|
Mineralization | | 1 2.0|
Nephropathy | 3 3 4 4 1 4 1 4 4 4 | 58 3.1|
Cortex, Infarct | | 2 2.5|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Pigmentation | 2 4 3 2 1 2 2 | 35 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Calculus Micro Observation Only | | 3 |
Inflammation | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
1.0 | 8| 8| 8| 9| 0| 2| 2| 3| 4| 4| | L |
LUNG TOX | 1| 5| 7| 3| 6| 2| 4| 1| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Ectasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 2 1 3 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 2 3 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Inflammation, Chronic Active | 1 3 1 2 3 | 5 2.0|
Alveolus, Hyperplasia, Macrophage | 3 4 3 3 4 | 5 3.4|
Alveolus, Proteinosis | 3 2 2 2 2 | 5 2.2|
Bronchus, Hyperplasia, Lymphoid | 1 1 1 1 | 4 1.0|
Interstitium, Infiltration Cellular | 1 2 2 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation, Chronic Active | 1 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05107-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:40:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
1.0 | 8| 8| 8| 9| 0| 2| 2| 3| 4| 4| | L |
LUNG TOX | 1| 5| 7| 3| 6| 2| 4| 1| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
Calculus Micro Observation Only | X X X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
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