National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1911

TDMS Study 05109-12 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          TRIETHANOLAMINE


NTP Experiment-Test: 05109-12                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  102-71-6

       Lock Date:  08/21/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            4            5           11                                     
    Natural Death                                      4            6            7            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           40           38           37                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               3 (5%)                                                          
      Hepatocellular Carcinoma                         1 (2%)       4 (7%)       7 (12%)      5 (8%)                                
      Hepatocellular Adenoma                          13 (22%)     15 (25%)     12 (20%)     12 (20%)                               
      Hepatocellular Adenoma, Multiple                11 (18%)      9 (15%)     13 (22%)     29 (48%)                               
      Histiocytic Sarcoma                                           2 (3%)       1 (2%)       3 (5%)                                
      Ito Cell Tumor NOS, Multiple                                  1 (2%)                                                          
   Mesentery                                          (2)          (5)          (5)          (5)                                    
      Histiocytic Sarcoma                                                                     1 (20%)                               
      Fat, Sarcoma, Metastatic, Skin                                1 (20%)                                                         
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (60)                                   
      Capsule, Spindle Cell, Adenoma                   1 (2%)                    1 (2%)       1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (54)         (59)         (59)         (59)                                   
      Adenoma                                                       1 (2%)                                                          
      Pars Distalis, Adenoma                           4 (7%)       5 (8%)       4 (7%)       5 (8%)                                
      Pars Intermedia, Adenoma                                      1 (2%)                    2 (3%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, Follicular Cell, Adenoma                                                     1 (2%)                                
      Follicular Cell, Adenoma                         4 (7%)       2 (3%)       5 (8%)       5 (8%)                                
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (60)         (59)         (60)                                   
      Cystadenoma                                      5 (8%)                    3 (5%)       2 (3%)                                
      Granulosa Cell Tumor Benign                      1 (2%)       1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Luteoma                                          3 (5%)       2 (3%)                                                          
      Teratoma NOS                                                  1 (2%)       1 (2%)                                             
      Follicle, Cystadenoma                                                      1 (2%)                                             
   Uterus                                             (60)         (60)         (59)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
      Polyp Stromal                                    1 (2%)       1 (2%)       1 (2%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (4)          (8)          (6)          (9)                                    
      Bronchial, Hemangiosarcoma, Metastatic,                                                                                       
          Uncertain Primary Site                       1 (25%)                                                                      
      Bronchial, Sarcoma, Metastatic, Skin                                       1 (17%)                                            
      Mediastinal, Sarcoma, Metastatic, Skin                                     1 (17%)                                            
                                                             Page   3                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Teratoma NOS, Metastatic, Ovary                  1 (13%)                                                         
      Pancreatic, Histiocytic Sarcoma                                                         1 (11%)                               
   Lymph Node, Mandibular                             (57)         (59)         (59)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)                    2 (3%)                                
   Lymph Node, Mesenteric                             (54)         (59)         (56)         (59)                                   
      Histiocytic Sarcoma                                                                     2 (3%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                  3 (5%)       1 (2%)                                                          
      Histiocytic Sarcoma                                           2 (3%)       1 (2%)       2 (3%)                                
      Capsule, Sarcoma, Metastatic, Skin                            1 (2%)                                                          
   Thymus                                             (55)         (57)         (58)         (58)                                   
      Histiocytic Sarcoma                                                        1 (2%)       2 (3%)                                
      Sarcoma, Metastatic, Skin                                     1 (2%)       1 (2%)                                             
      Thymoma NOS                                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (57)         (60)         (57)                                   
      Adenoma                                                                    1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Skin                                               (60)         (60)         (60)         (60)                                   
      Inguinal, Subcutaneous Tissue, Osteosarcoma                                1 (2%)                                             
      Neck, Subcutaneous Tissue, Sarcoma                                         1 (2%)                                             
      Pinna, Sarcoma                                                1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                             1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Lumbar, Vertebra, Sarcoma                                                  1 (2%)                                             
      Scapula, Osteosarcoma                                                                   1 (2%)                                
      Vertebra, Osteosarcoma                                                                  1 (2%)                                
   Skeletal Muscle                                                 (2)          (2)                                                 
      Fibrosarcoma                                                  1 (50%)                                                         
      Diaphragm, Sarcoma, Metastatic, Skin                          1 (50%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)       5 (8%)       2 (3%)       5 (8%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)       2 (3%)                                
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Hemangiosarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                 1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       2 (3%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Osteosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Osteosarcoma, Metastatic, Tissue NOS                                                    1 (2%)                                
      Sarcoma, Metastatic, Bone                                                  1 (2%)                                             
      Sarcoma, Metastatic, Skin                                     1 (2%)       1 (2%)                                             
      Mediastinum, Sarcoma, Metastatic, Skin                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (2)          (1)                                                 
      Adenoma                                          1 (100%)     1 (50%)      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                           2 (3%)       2 (3%)       3 (5%)                                
      Leukemia Lymphocytic                                                       1 (2%)       1 (2%)                                
      Lymphoma Malignant                                                                      1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)       5 (8%)       3 (5%)       4 (7%)                                
      Lymphoma Malignant Mixed                         4 (7%)       4 (7%)       1 (2%)       7 (12%)                               
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       1 (2%)       2 (3%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          46          44          52                                       
     Total Primary Neoplasms                           60          73          68          95                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          36          33          46                                       
     Total Benign Neoplasms                            46          46          45          65                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              11          22          21          25                                       
     Total Malignant Neoplasms                         14          25          22          29                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           3           3                                       
     Total Metastatic Neoplasm                          2          10           8           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              2           1           1                                       
     Total Uncertain Neoplasms                                      2           1           1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            5            3            6                                     
    Natural Death                                      2            5            8            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                46           39           39           41                                     
    Natural Death                                                   1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Carcinoma                                                                               1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hemangioma                                                    1 (2%)                    1 (2%)                                
      Hemangiosarcoma                                               3 (5%)       1 (2%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        2 (3%)                                                                       
      Hepatoblastoma                                                                          3 (5%)                                
      Hepatocellular Carcinoma                        10 (17%)     14 (23%)      8 (13%)     10 (17%)                               
      Hepatocellular Carcinoma, Multiple               6 (10%)      8 (13%)      7 (12%)      5 (8%)                                
      Hepatocellular Adenoma                          10 (17%)     11 (18%)     13 (22%)     12 (20%)                               
      Hepatocellular Adenoma, Multiple                18 (30%)     18 (30%)     17 (28%)     29 (48%)                               
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Mesentery                                                       (3)                       (1)                                    
      Carcinoma, Metastatic, Pancreas                               1 (33%)                                                         
      Hepatoblastoma, Metastatic, Liver                                                       1 (100%)                              
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Carcinoma                                                     1 (2%)                                                          
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Carcinoid Tumor NOS                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Capsule, Spindle Cell, Adenoma                   1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, Follicular Cell, Adenoma                                                     1 (2%)                                
      Follicular Cell, Adenoma                         2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Hemangioma                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Sarcoma                                                                    1 (2%)                                             
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
   Testes                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma                         1 (2%)                                                          
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (2)          (2)          (3)          (1)                                    
      Lumbar, Histiocytic Sarcoma                                                1 (33%)                                            
      Mediastinal, Carcinoma, Metastatic, Pancreas                  1 (50%)                                                         
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (50%)                                                         
      Pancreatic, Hepatoblastoma, Metastatic, Liver                                           1 (100%)                              
   Lymph Node, Mandibular                             (57)         (57)         (57)         (57)                                   
   Lymph Node, Mesenteric                             (56)         (57)         (53)         (55)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hepatoblastoma, Metastatic, Liver                                                       1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (53)         (46)         (57)         (52)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Neck, Basal Cell Carcinoma                       1 (2%)                                                                       
      Neck, Subcutaneous Tissue, Hemangiosarcoma                    1 (2%)                                                          
      Neck, Subcutaneous Tissue, Fat, Hemangioma                                              1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Carcinoma, Metastatic, Pancreas                               1 (100%)                                                        
      Hemangiosarcoma                                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    14 (23%)     11 (18%)     14 (23%)      8 (13%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       4 (7%)                    2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       5 (8%)       1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       6 (10%)      3 (5%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (5)          (6)          (1)                                    
      Adenoma                                          4 (100%)     5 (100%)     5 (83%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Renal Tubule, Adenoma                            1 (2%)                                 2 (3%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leukemia Lymphocytic                                                       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                             3 (5%)                                             
      Lymphoma Malignant Mixed                         4 (7%)       1 (2%)       5 (8%)       1 (2%)                                
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05109-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/20/95  
Route: DERMAL,SOLUTION                                                                                            Time: 00:11:45  
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         B6C3F1 MICE MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          49          43          53                                       
     Total Primary Neoplasms                           82          87          80          85                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          40          36          45                                       
     Total Benign Neoplasms                            55          53          51          58                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          30          25          24                                       
     Total Malignant Neoplasms                         27          33          29          27                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           7           3           3                                       
     Total Metastatic Neoplasm                          4          13           3           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.