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TDMS Study 05109-11 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          TRIETHANOLAMINE


NTP Experiment-Test: 05109-11                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  102-71-6

       Lock Date:  07/29/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                     14           17           13           15                                     
    Moribund Sacrifice                                11            4           12           17                                     
  Survivors                                                                                                                         
    Natural Death                                                                             1                                     
    Terminal Sacrifice                                25           29           25           17                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Periesophageal Tissue, Lipoma                                              1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Adenoma                                                                  1 (2%)                                
   Mesentery                                          (3)          (2)          (2)          (2)                                    
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                                           1 (50%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma Benign                                             1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (59)                                   
      Pheochromocytoma Benign                                       1 (2%)                    1 (2%)                                
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                                       2 (3%)                    2 (3%)                                
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (51)         (57)         (57)         (51)                                   
      Adenoma                                          1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Pars Distalis, Adenoma                          32 (53%)     26 (43%)     31 (52%)     27 (45%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (60)         (59)                                   
      C-Cell, Adenoma                                  1 (2%)       2 (3%)       2 (3%)       5 (8%)                                
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenoma                         2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (59)         (60)         (60)                                   
      Adenoma                                          2 (3%)       6 (10%)      2 (3%)       2 (3%)                                
      Carcinoma                                        1 (2%)                                                                       
      Bilateral, Carcinoma                             1 (2%)                                                                       
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Stromal                                    4 (7%)       2 (3%)       8 (13%)      7 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (6)          (5)          (6)          (3)                                    
      Mediastinal, Rhabdomyosarcoma, Metastatic,                                                                                    
           Skeletal Muscle                                                                    1 (33%)                               
      Mediastinal, Schwannoma Malignant,                                                                                            
          Metastatic, Heart                                         1 (20%)                                                         
   Lymph Node, Mandibular                             (59)         (60)         (60)         (60)                                   
   Lymph Node, Mesenteric                             (60)         (60)         (59)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
   Thymus                                             (59)         (57)         (57)         (58)                                   
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                                           1 (2%)                                
      Thymoma Benign                                                             1 (2%)                                             
      Thymoma Malignant                                                                       1 (2%)                                
      Mediastinum, Schwannoma Malignant,                                                                                            
          Metastatic, Heart                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
      Fibroadenoma                                    12 (20%)     13 (22%)      7 (12%)      6 (10%)                               
      Fibroadenoma, Multiple                           1 (2%)                    3 (5%)       2 (3%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Face, Squamous Cell Papilloma                    1 (2%)                                                                       
      Inguinal, Keratoacanthoma                                     1 (2%)                                                          
      Subcutaneous Tissue, Neurofibrosarcoma           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                    (2)                                    
      Hemangiosarcoma                                  1 (100%)                                                                     
      Rhabdomyosarcoma                                                                        1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Medulloblastoma NOS                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Mediastinum, Rhabdomyosarcoma, Metastatic,                                                                                    
           Skeletal Muscle                                                                    1 (2%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (2)          (1)                                    
      Middle Ear, Carcinoma, Metastatic, Zymbal's                                                                                   
          Gland                                                                               1 (100%)                              
      Pinna, Fibrosarcoma                                                        1 (50%)                                            
   Zymbal's Gland                                     (1)          (1)                       (1)                                    
      Carcinoma                                        1 (100%)     1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (59)         (60)         (60)         (60)                                   
      Leiomyoma                                                                  1 (2%)                                             
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            13 (22%)     14 (23%)     13 (22%)     16 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      63 MG/KG     125          250                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          44          47          44                                       
     Total Primary Neoplasms                           79          79          77          76                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          39          42          37                                       
     Total Benign Neoplasms                            59          61          62          55                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          17          13          18                                       
     Total Malignant Neoplasms                         20          18          15          20                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1                       2                                       
     Total Metastatic Neoplasm                                      2                       5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           59           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9           12            6            8                                     
    Moribund Sacrifice                                18           27           25           23                                     
    Accidently Killed                                  2                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           11           18           19                                     
  Animals Examined Microscopically                    60           60           59           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (59)         (60)                                   
      Leiomyosarcoma                                                1 (2%)                                                          
   Intestine Small, Duodenum                          (60)         (60)         (59)         (60)                                   
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                    1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Glandular                                                              1 (2%)                                             
   Intestine Small, Jejunum                           (60)         (60)         (59)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Spleen                                                1 (2%)                                
      Mast Cell Tumor Malignant                                                               1 (2%)                                
   Intestine Small, Ileum                             (60)         (60)         (59)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Spleen                                                1 (2%)                                
   Liver                                              (60)         (60)         (59)         (60)                                   
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                           3 (5%)                                 1 (2%)                                
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                    1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Glandular                                                              1 (2%)                                             
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Mesentery                                          (9)          (10)         (11)         (5)                                    
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                    1 (10%)                                                         
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Glandular                                                              1 (9%)                                             
   Pancreas                                           (60)         (60)         (59)         (60)                                   
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                    1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Glandular                                                              1 (2%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (60)         (60)         (58)         (60)                                   
      Neurofibrosarcoma, Metastatic, Skin                           1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                    1 (2%)                                                          
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (59)         (59)                                   
   Heart                                              (60)         (60)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (59)         (60)                                   
   Adrenal Medulla                                    (60)         (60)         (59)         (60)                                   
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                          2 (3%)       8 (13%)      5 (8%)       3 (5%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Adenoma                                          1 (2%)       3 (5%)       3 (5%)       5 (8%)                                
   Parathyroid Gland                                  (55)         (57)         (53)         (56)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (58)         (60)                                   
      Pars Distalis, Adenoma                          37 (62%)     40 (67%)     35 (60%)     39 (65%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)       1 (2%)       2 (3%)       4 (7%)                                
   Thyroid Gland                                      (60)         (60)         (59)         (60)                                   
      Neurofibrosarcoma, Metastatic, Skin                           1 (2%)                                                          
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  6 (10%)      4 (7%)       8 (14%)      6 (10%)                               
      C-Cell, Carcinoma                                             1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (59)         (60)                                   
   Preputial Gland                                    (60)         (60)         (58)         (60)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Fibrosarcoma                                                  1 (2%)                                                          
   Prostate                                           (60)         (59)         (59)         (60)                                   
      Adenocarcinoma                                   1 (2%)       1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
   Seminal Vesicle                                    (60)         (60)         (59)         (60)                                   
   Testes                                             (60)         (60)         (59)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           16 (27%)     14 (23%)     16 (27%)      9 (15%)                               
      Interstitial Cell, Adenoma                      18 (30%)     26 (43%)     21 (36%)     20 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (59)         (60)                                   
   Lymph Node                                         (15)         (10)         (16)         (9)                                    
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                          1 (6%)                                             
   Lymph Node, Mandibular                             (60)         (60)         (59)         (60)                                   
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (60)         (59)         (59)                                   
   Spleen                                             (60)         (60)         (59)         (60)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Thymus                                             (56)         (59)         (58)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (53)         (54)         (54)                                   
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Fibroadenoma                                     1 (2%)                                                                       
   Skin                                               (60)         (60)         (59)         (60)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Keratoacanthoma                                  1 (2%)                                                                       
      Abdominal, Ventral, Keratoacanthoma                                                     1 (2%)                                
      Dorsal, Keratoacanthoma                                                    1 (2%)                                             
      Face, Basosquamous Tumor Malignant                            1 (2%)                                                          
      Face, Squamous Cell Papilloma                    2 (3%)                    1 (2%)                                             
      Head, Basosquamous Tumor Benign                                                         1 (2%)                                
      Hindlimb, Subcutaneous Tissue, Fibroma           1 (2%)                                                                       
      Inguinal, Keratoacanthoma                        1 (2%)                                                                       
      Inguinal, Subcutaneous Tissue, Fibrosarcoma                                1 (2%)                                             
      Inguinal, Subcutaneous Tissue, Sarcoma                                                  1 (2%)                                
      Neck, Subcutaneous Tissue, Schwannoma                                                                                         
                                                             Page   9                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
          Malignant                                                 1 (2%)                                                          
      Pinna, Sarcoma                                                                          1 (2%)                                
      Pinna, Squamous Cell Papilloma                   1 (2%)                                                                       
      Site of Application-Mass, Basal Cell Adenoma     1 (2%)                                                                       
      Site of Application-Mass, Keratoacanthoma                                               1 (2%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma,                                                                                    
           Metastatic, Spleen                                                                 1 (2%)                                
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Neurofibrosarcoma                        1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Ventral, Fibroma                                      1 (2%)                                             
      Tail, Fibrosarcoma                               1 (2%)                                                                       
      Thoracic, Keratoacanthoma                        2 (3%)                    1 (2%)                                             
      Thoracic, Subcutaneous Tissue, Fibroma                        1 (2%)       1 (2%)                                             
      Ventral, Keratoacanthoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)          (1)                                    
      Neurofibrosarcoma, Metastatic, Skin                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (58)         (60)                                   
      Astrocytoma NOS                                                                         1 (2%)                                
   Spinal Cord                                        (2)                       (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Nose                                               (60)         (60)         (59)         (60)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (2)          (1)                                    
   Zymbal's Gland                                                  (2)          (2)          (1)                                    
      Carcinoma                                                     2 (100%)     1 (50%)      1 (100%)                              
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                                                             Page  10                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                    1 (2%)                                                          
      Renal Tubule, Adenoma                                         1 (2%)       4 (7%)       2 (3%)                                
   Urinary Bladder                                    (60)         (60)         (58)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(59)        *(60)                                   
      Leukemia Mononuclear                            25 (42%)     16 (27%)     21 (36%)     22 (37%)                               
      Mesothelioma NOS                                 3 (5%)                    2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05109-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 05/19/95  
Route: DERMAL,SOLUTION                                                                                            Time: 23:24:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      32 MG/KG     63 MG/KG     125                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53          58          57          55                                       
     Total Primary Neoplasms                          134         131         132         124                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          58          56          53                                       
     Total Benign Neoplasms                           100         101         102          94                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          23          27          26                                       
     Total Malignant Neoplasms                         31          30          28          27                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          5           2           1                                       
     Total Metastatic Neoplasm                                     15           5           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  3                       2           3                                       
     Total Uncertain Neoplasms                         16                       6          12                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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