National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/895

TDMS Study 05109-11 Pathology Tables

NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  102-71-6

       Lock Date:  07/29/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|             
                                           | 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X  X  X        X  X        X  X                       X  X     X   |             
      Clear Cell Focus                     |                                                                   X      |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X              X                          X                           |             
      Inflammation, Chronic                |             2  1        1  1  1  1     1  1           1  1     1         |             
      Inflammation, Necrotizing            |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               | 3     1  1                    1                 3                        |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Fat, Inflammation, Necrotizing       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                        3        1           2            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Duct, Ectasia                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Epithelium, Hyperplasia              |                                                 3                    2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1  1  1           1  2  1  1     1     1        1  1  1  1  1  1  2  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Atrium, Thrombosis                   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|             
                                           | 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |          2                                      1              2  2  2   |             
      Hyperplasia                          |          2              1        1     2                       2         |             
      Hypertrophy                          |                                                                      3   |             
      Necrosis, Coagulative                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                            1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                                                                          |             
      Pars Distalis, Angiectasis           |          2     3     1  2     4  3     2     2  3        3  2  2     3  3|             
      Pars Distalis, Cyst                  | X     X  X  X     X  X  X        X  X     X     X              X  X     X|             
      Pars Distalis, Hyperplasia           |    3  2  2  3        3                    3        2  2     2     2     3|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    2     2  2           2     2  2              2  2     2  2  2  2     2|             
      Pars Intermedia, Cyst                |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         1                                         1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |             1           1     3     3  1                       2  1      |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                          X               |             
      Hematocyst                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Glandular       |                                                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +                                      +                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|             
                                           | 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  2     2  2  4  2     2  2  2  2  2  2  2     2  2  2  2  2  3  2|             
      Inflammation, Chronic Active         |                2                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |                                                                          |             
      Face, Abscess                        |                                                                          |             
      Head, Inflammation, Chronic Active   |                                                                   3      |             
      Inguinal, Acanthosis                 |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                  1                                       |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X  X              X  X           X           X           X   |             
      Hemorrhage                           |    1           2              2                                          |             
      Hydrocephalus                        |                3              2              2           3               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                +                                                  +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1  2              1        1                       1     1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|             
                                           | 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Mononuclear Cell                |    1        1        1  1  1  1     1  1        1     1     1  1     1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2     1  2                                      2        2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 3  3        3  3                    2  2                          3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    2  2  1  2  1  1  2  2     1  2  1  2  1  1  1     1  2  2  2  1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|             
                                           | 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                        X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X        X           X                    X  X              X  X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X                 X                          X  X  X  X         |             
      Inflammation, Chronic                |    2                 1     1  1  1                             1        1|             
      Inflammation, Necrotizing            |                2                                                         |             
      Necrosis, Coagulative                |                         2                                                |             
      Bile Duct, Hyperplasia               | 1        1                 1     1                       1     1         |             
      Hepatocyte, Vacuolization Cytoplasmic|       3     2                       3                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Inflammation, Necrotizing       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                   2                                                      |             
      Artery, Inflammation, Chronic Active |                                              3                           |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |       4           4                                                      |             
      Epithelium, Hyperplasia              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                   2                                                      |             
      Inflammation, Necrotizing            |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |       1  1     1     1     1  2  1  2  2  1     1  1     1  2  2  2  1  1|             
      Inflammation, Chronic Active         |    2                                                                     |             
      Atrium, Thrombosis                   |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|             
                                           | 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2  3     2     3     1                                      1  1      |             
      Hyperplasia                          |       2     2  2                                2              1  2      |             
      Hypertrophy                          |                                                                      2   |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2     1     2                 2           1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |       X                                                                  |             
      Pars Distalis, Angiectasis           |    2  3     3  3        3     2     1  3  3  4  3     3  4  2  4  2     2|             
      Pars Distalis, Cyst                  | X  X              X  X  X  X     X  X     X  X     X                 X   |             
      Pars Distalis, Hyperplasia           |                            2  2     2                             2      |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    2        2  2        2              2  2  2  2     2  2     2  2  2   |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     2        1                    1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                             2  2                                    |             
      Inflammation, Chronic Active         |                1                    3        2                    2      |             
      Duct, Dilatation                     |                                           4  3                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              4                           |             
      Cyst                                 |                                                                      X   |             
      Hematocyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Glandular       |                                              2                           |             
      Lumen, Hemorrhage                    |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +                    +                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|             
                                           | 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     2                                    |             
      Hematopoietic Cell Proliferation     |                               3                                          |             
      Red Pulp, Atrophy                    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    1  2        2  2  2        2  2  2     2  2  2  2  2  4  3  2  4     1|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |                                                 3                        |             
      Face, Abscess                        |                                           4                              |             
      Head, Inflammation, Chronic Active   |                                                                          |             
      Inguinal, Acanthosis                 |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                                                 2     2                  |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     |                                                 2     3                  |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        |                                                 3     4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X  X        X                 X     X     X  X              X|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |             3                             2           2  2               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1                 1     3  1  1     2        1              2      |             
      Alveolar Epithelium, Hyperplasia     |                                                 1              1         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|             
                                           | 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Mononuclear Cell                |    1  1  1           1  1              1  3  1  1  1  1     1  1  1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                2  3     2                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       3        2                                            3        2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                       +                                             |             
      Lens, Cataract                       |    4                       4                                             |             
      Retina, Atrophy                      |    4                       4                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1  3  1  3  2  1  1  1  1  1  1  3  2  2  2  2  1  2  1  2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 6| 7| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5|                                            |            |
                                           | 0| 7| 1| 8| 0| 9| 9| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Perforation                          |       X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                         X                                                |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                         2                                                |      1  2.0|
      Basophilic Focus                     |                X     X  X                                                |     21     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                X        X                                                |      2     |
      Hepatodiaphragmatic Nodule           |    X                 X                                                   |     11     |
      Inflammation, Chronic                |    1           1     1                                                   |     21  1.1|
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                            2                                             |      2  2.0|
      Bile Duct, Hyperplasia               | 2  1     2     1        1                                                |     16  1.4|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   3        |
      Fat, Inflammation, Necrotizing       |             3                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |                         2                                                |      5  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |                                                                          |      2  4.0|
      Epithelium, Hyperplasia              |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 6| 7| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5|                                            |            |
                                           | 0| 7| 1| 8| 0| 9| 9| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy, Chronic              | 1  1        1  1        2                                                |     41  1.2|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Fatty                  | 1        2              2                                                |     15  1.8|
      Hyperplasia                          | 2              1  1     2                                                |     15  1.7|
      Hypertrophy                          |                                                                          |      2  2.5|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |             1  1                                                         |      9  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |            |
           Cyst                            |                                                                          |      1     |
      Pars Distalis, Angiectasis           | 2     4  1  4        2     3                                             |     37  2.6|
      Pars Distalis, Cyst                  | X                 X  X  X                                                |     30     |
      Pars Distalis, Hyperplasia           |          2     2  3                                                      |     18  2.3|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      | 2     2  2  2     2  2  2                                                |     33  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  | 1                    2                                                   |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      3  2.0|
      Inflammation, Chronic Active         |                                                                          |     11  1.8|
      Duct, Dilatation                     |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |    X                                                                     |      3     |
      Hematocyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 6| 7| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5|                                            |            |
                                           | 0| 7| 1| 8| 0| 9| 9| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic, Glandular       |                                                                          |      1  2.0|
      Lumen, Hemorrhage                    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                   3                                                      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                            3                                             |      2  3.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  | 2     2  2  3  2  2  2                                                   |     47  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Epidermis, Site of Application-No    |                                                                          |            |
          Mass, Erosion                    |                                                                          |      1  3.0|
      Face, Abscess                        |                                                                          |      1  4.0|
      Head, Inflammation, Chronic Active   |                                                                          |      1  3.0|
      Inguinal, Acanthosis                 | 1                                                                        |      1  1.0|
      Inguinal, Inflammation, Chronic      |                                                                          |            |
          Active                           | 1                                                                        |      2  1.0|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       |                                                                          |      2  2.0|
      Site of Application-No Mass,         |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      2  2.5|
      Site of Application-No Mass, Ulcer,  |                                                                          |            |
           Multiple                        |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 6| 7| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5|                                            |            |
                                           | 0| 7| 1| 8| 0| 9| 9| 0| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          | X           X        X                                                   |     18     |
      Hemorrhage                           |                                                                          |      3  1.7|
      Hydrocephalus                        | 2           3                                                            |     10  2.4|
      Necrosis                             |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 2           1                                                            |     16  1.4|
      Alveolar Epithelium, Hyperplasia     |                         3                                                |      4  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                | 1              1  1  1  1  1                                             |     34  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 2                                                                        |      9  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |     11  2.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      2  4.0|
      Retina, Atrophy                      |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy, Chronic                 | 2  1  1  1  2  1     2                                                   |     54  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|             
                                           | 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                 X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X  X                                      X                 X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1                 1                                    |             
      Basophilic Focus                     | X     X  X           X           X  X  X  X     X                       X|             
      Clear Cell Focus                     | X                                                                        |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X                                                     X     X      |             
      Inflammation, Chronic                | 1        1        1           1           1  1           1        1      |             
      Inflammation, Necrotizing            |             4                                                            |             
      Mixed Cell Focus                     |          X                                                               |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               |    2                    1     1  1        1                              |             
      Hepatocyte, Vacuolization Cytoplasmic|                      2                                                   |             
      Kupffer Cell, Hypertrophy            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Fat, Inflammation, Necrotizing       |                                        4                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                         1        1        1              1     1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                             3            |             
      Epithelium, Hyperplasia              |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    1        1  1  2        1  1     1        1     1     1        1  2  1|             
      Atrium, Thrombosis                   |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2  1              1              1  1     2        2                 2|             
      Hyperplasia                          |    2  1              2              2  2  1           2        2     1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|             
                                           | 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    1  1                                         1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                                                                          |             
      Pars Distalis, Angiectasis           | 3     4  4     2  3  2  2  2        2  3  2           4     2     1  1  2|             
      Pars Distalis, Cyst                  |    X  X     X                 X     X        X  X  X     X           X  X|             
      Pars Distalis, Hyperplasia           |    2                             2        2  2  2  2     2     2  2  2  3|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2     2  2     2  2  2  2           2  2  2           2     2        2  2|             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                    2                                          |             
      Follicular Cell, Hyperplasia         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        2                                3                    2         |             
      Inflammation, Chronic Active         | 1     1                       1           2     2              3        1|             
      Duct, Dilatation                     |                                                                4         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                                            3  3            |             
      Myelofibrosis                        |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                             3            |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  1     2  2  3  1           2  2  1     2     2  2  2  1        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|             
                                           | 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |                                                                      3   |             
      Inguinal, Acanthosis                 |                   2                                                      |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                   1                                                      |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |    2  2           2                                                  2  1|             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     |    4  2           2                                                  2   |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        |    4  3           2                                                  4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Maxilla, Abscess                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X  X     X  X  X  X                             X     X            |             
      Hydrocephalus                        |          2     2  2  2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1              1     2           1  1     1     1        1               |             
      Inflammation, Necrotizing            |             4                                                            |             
      Metaplasia, Osseous                  |                   1                                                      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |    1  1  1        1  1  1     1  1  1     1     1  1  1  1  3  1     1  1|             
      Perivascular, Edema                  |                                                             3            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2                                1                                      2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2  3              2                                            2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Lens, Cataract                       |                                                    4                     |             
      Retina, Atrophy                      |                                                    4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|             
                                           | 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1  1  2     1  2  2           1  2  2  2  1  1     2  1  3  1  1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|             
                             DAY ON TEST   | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|             
                                           | 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X     X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                    X                    X  X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        1                                 |             
      Basophilic Focus                     |       X  X     X  X        X  X     X  X        X  X     X     X  X      |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                               X     X        X  X              X         |             
      Inflammation, Chronic                | 1     1  1                       2                                1     1|             
      Inflammation, Necrotizing            |                                                                          |             
      Mixed Cell Focus                     |             X                                                            |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               | 1        1  3           2              1     2                          1|             
      Hepatocyte, Vacuolization Cytoplasmic|             3                                                            |             
      Kupffer Cell, Hypertrophy            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Fat, Inflammation, Necrotizing       |                                                          4               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                1                    2  2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |             4           3                                                |             
      Epithelium, Hyperplasia              |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |             2           2                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1  1              1  1  2     1     1        1        1  1  1  1  2   |             
      Atrium, Thrombosis                   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |       3        1     2                    3        1           1         |             
      Hyperplasia                          |          2     2              1     1        1  1  1     2     1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|             
                             DAY ON TEST   | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|             
                                           | 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                     1        1     1     1     1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                                                          X               |             
      Pars Distalis, Angiectasis           |       2  2     3        1  4  2     2     3     2     4  2  2        4   |             
      Pars Distalis, Cyst                  |    X        X           X        X     X                       X        X|             
      Pars Distalis, Hyperplasia           |    2     3              2                       3        2     2  2     2|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       2  2     2           2              2     2     2     2        2   |             
      Pars Intermedia, Cyst                |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1                                2                    3   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                3                           |             
      Inflammation, Chronic Active         |    1  1        4  1        2  1  1  1              2     2               |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +           +                    +                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Lipocyte      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2  2  1  2  2  1  2  2  2  2  2  1     2  2     1  3  2  2  1  2     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|             
                             DAY ON TEST   | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|             
                                           | 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |       3  3           3                             3                 3   |             
      Inguinal, Acanthosis                 |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       | 2     3  3           2                             2                     |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     | 2     2  3           2                             2                 2   |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        | 2        4           3                                               4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                3                       3                                 |             
      Maxilla, Abscess                     |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            X              X           X     X        X   |             
      Hydrocephalus                        |                            2                          3              2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1        1              1  1  1        1  1                     |             
      Inflammation, Necrotizing            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                | 1  1  1  1     1  1           1  1  1  1  1  1  1  1  1  1     1  1      |             
      Perivascular, Edema                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          2                                               3               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2        2           1                                      2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     | +        +                                                               |             
      Lens, Cataract                       | 4        4                                                               |             
      Retina, Atrophy                      | 4        4                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|             
                             DAY ON TEST   | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|             
                                           | 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    63 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1  1  2  1  2  2  2  1  2  1  1  2  2  2     2  1  1  2  1  2  1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 5| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3|                                            |            |
                                           | 0| 6| 1| 9| 9| 1| 3| 7| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    63 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      3  1.0|
      Basophilic Focus                     |             X  X  X     X  X                                             |     28     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |             X                                                            |      1     |
      Hepatodiaphragmatic Nodule           | X        X              X                                                |     11     |
      Inflammation, Chronic                | 1  1     1  2  1  1  1  1                                                |     22  1.1|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis, Coagulative                |       2                                                                  |      1  2.0|
      Bile Duct, Hyperplasia               |                1  1  1                                                   |     15  1.3|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  2.5|
      Kupffer Cell, Hypertrophy            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Inflammation, Necrotizing       |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |    1                                                                     |      9  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |    3                                                                     |      4  3.3|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy, Chronic              | 1  1        2  1  1  1                                                   |     33  1.2|
      Atrium, Thrombosis                   |       X                                                                  |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 5| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3|                                            |            |
                                           | 0| 6| 1| 9| 9| 1| 3| 7| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    63 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Fatty                  |                         2  1                                             |     16  1.6|
      Hyperplasia                          |             1           2  2                                             |     21  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      8  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |            |
           Cyst                            |                                                                          |      1     |
      Pars Distalis, Angiectasis           | 2        4  4  2        3  2                                             |     35  2.5|
      Pars Distalis, Cyst                  | X  X                 X     X                                             |     22     |
      Pars Distalis, Hyperplasia           | 2  3  4        3           2                                             |     24  2.3|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      | 2     2  2     2        2  2                                             |     29  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |                                                                          |      5  1.8|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |          2  2                                                            |      8  2.3|
      Inflammation, Chronic Active         | 1        2                                                               |     19  1.6|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |       X     X  X                                                         |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  3.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                 +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 5| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3|                                            |            |
                                           | 0| 6| 1| 9| 9| 1| 3| 7| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    63 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  | 1  2        2  2  2        2                                             |     44  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Epidermis, Site of Application-No    |                                                                          |            |
          Mass, Erosion                    |                                                                          |      6  3.0|
      Inguinal, Acanthosis                 |                                                                          |      1  2.0|
      Inguinal, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       |       2                                                                  |     11  2.1|
      Site of Application-No Mass,         |                                                                          |            |
          Inflammation, Chronic Active     |       2                                                                  |     11  2.3|
      Site of Application-No Mass, Ulcer,  |                                                                          |            |
           Multiple                        |                                                                          |      8  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Osteopetrosis                        |             3                                                            |      3  3.0|
      Maxilla, Abscess                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |             X           X                                                |     15     |
      Hydrocephalus                        |             3           2                                                |      9  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |          1  1  2                                                         |     18  1.1|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 5| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3|                                            |            |
                                           | 0| 6| 1| 9| 9| 1| 3| 7| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    63 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Mononuclear Cell                | 1     1  1  1  1     1     1                                             |     43  1.0|
      Perivascular, Edema                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      5  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   1                                                      |      9  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   4        |
      Lens, Cataract                       |                                                                          |      3  4.0|
      Retina, Atrophy                      |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy, Chronic                 | 1  1     1  1  1  1  1  2  2                                             |     52  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|             
                                           | 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    125                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                                              3   |             
      Basophilic Focus                     |          X  X  X     X                 X  X  X     X     X     X  X  X  X|             
      Eosinophilic Focus                   |       X  X                                      X                        |             
      Hepatodiaphragmatic Nodule           |             X           X  X                             X              X|             
      Inflammation, Chronic                | 1        1  1  1     2  1        1  1              1              1     1|             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |          1  1     1  1                       1              2     1      |             
      Hepatocyte, Vacuolization Cytoplasmic|    2                                                                 2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1     1     1                       1              2           1      |             
      Artery, Inflammation, Chronic Active |                      3                                                   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Polyarteritis, Chronic        |                                                                          |             
      Mesenteric Artery, Polyarteritis,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1     2  1  1  1  1     1     1     1  1        1     2  1  2  1  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|             
                                           | 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    125                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |             1  1     1                    3  1                 1     2   |             
      Hyperplasia                          |             2  1                       2  1  1                 2     2  2|             
      Hypertrophy                          |                                                                2         |             
      Karyomegaly                          |                                                                         1|             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                         1  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 4  4  3  4  2  2     3     2     3     2  2  2  3     3     4  2  3  4   |             
      Pars Distalis, Cyst                  |             X           X     X     X  X  X  X     X           X        X|             
      Pars Distalis, Hyperplasia           |             2           2  2        2     3  3     3              2     2|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    2  2     2  2                 2        2     2     2           2  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  2              2                                               2   |             
      Follicle, Cyst                       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |             1  1                          1  2     2              1      |             
      Duct, Dilatation                     |                      3           2                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                         X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                       +                                             |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mediastinal, Sinus, Infiltration     |                                                                          |             
          Cellular, Mononuclear Cell       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|             
                                           | 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    125                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Red Pulp, Atrophy                    |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  1  2  2  1  1     3  2  3  2  1  2  3  2  2  2  3  1     2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    | 3        3     3                       3           3  3  3        3      |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |             1                                                     1      |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       | 2  1     1  2  2     2     2  2     2  2  3        3  2  2        2  2   |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     | 2  2     2  2  2     2     2  2     2  2  3        2  2  2        3  2   |             
      Site of Application-No Mass, Ulcer   |          2                    2                                          |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        | 4              3     2              2  4  4        4  4  4        4  2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X  X                 X                          X     X     X        X   |             
      Hydrocephalus                        | 3  2                 2                          3                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                    1              1        1                 1     1  1|             
      Alveolar Epithelium, Hyperplasia     |                                           4                              |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |          1  1  1     1  1        1     1  1  1     1        1  1  1  1  1|             
      Artery, Mediastinum, Polyarteritis,  |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1  2                                                            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                1                                                     3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|             
                                           | 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    125                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Eye                                     |       +              +                                         +         |             
      Lens, Cataract                       |       4              4                                         4         |             
      Retina, Atrophy                      |       4              4                                         4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2  2  2  2  1     2  1  2  1     1     1  2  2  1  2  1     2  1  3  2|             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|             
                                           | 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                             X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X     X        X     X                       X  X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                 4                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X     X     X        X  X  X     X     X  X        X  X  X         |             
      Eosinophilic Focus                   |                               X                                          |             
      Hepatodiaphragmatic Nodule           |          X                                               X  X            |             
      Inflammation, Chronic                | 1  1  1        1              1  1     2  1     1        1     1  2  1   |             
      Mixed Cell Focus                     |                                                 X                        |             
      Bile Duct, Hyperplasia               |    1           1     1  2     1  1                                      2|             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                         3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                1     1  1  1     2     1                 2  2  1         |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                         4                                               3|             
      Epithelium, Hyperplasia              |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Polyarteritis, Chronic        |                                                 2                        |             
      Mesenteric Artery, Polyarteritis,    |                                                                          |             
           Chronic                         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1     1     1  1  1     2  1  1  1  1  1  2  1     2     1     1     1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|             
                                           | 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                2        1  2  2  1  1  1              2     1  1        3|             
      Hyperplasia                          |                2  1        2  1  1                          2  2         |             
      Hypertrophy                          |                                                                         2|             
      Karyomegaly                          |                                                                          |             
      Necrosis, Coagulative                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             1  1  3        2  2           2  2        1  2  2     4     2|             
      Pars Distalis, Cyst                  | X     X        X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X     X   |             
      Pars Distalis, Hyperplasia           |             2        2     3  2  2     2     2  2     2        2        4|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                2     2  2  2  2  2  2     2              2  2     2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1                                   2  3     1         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                 3                                    |             
      Inflammation, Chronic Active         | 1                 2              1  1        1        1     1  3     1   |             
      Duct, Dilatation                     |                                                       3                 3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                               4                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                          +  +                    +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                      2                                                   |             
      Mediastinal, Sinus, Infiltration     |                                                                          |             
          Cellular, Mononuclear Cell       |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|             
                                           | 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1     2     2  2  1     2  2  2  2  2     2  3  2  3     2  2     3  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |                         3  3              3  3           3               |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       | 3  2  2        2     2  1  3  2     3     2  2  2        3        2  2   |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     | 2  2  2        1     3  2  2  2     4     2  2  2        3        2  2   |             
      Site of Application-No Mass, Ulcer   |       1        2                                                     1   |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        | 3  3                 4     4  2     4     4              4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         X                 X        X              X      |             
      Hydrocephalus                        |                                           2        2              2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1     2        1  1        2  1                 1  1         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                | 1  1  1           1        1  1     1        1  1  1     1  1  1  1  1   |             
      Artery, Mediastinum, Polyarteritis,  |                                                                          |             
           Chronic                         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1  2                                      2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             1        2                 1                          3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|             
                                           | 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                +                     |             
      Lens, Cataract                       |                   4                                4                     |             
      Retina, Atrophy                      |                   4                                4                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1     1     2  2  2  1  2  2  1  3  1  1  2  2           2  1  1  2  1  2|             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 6| 7| 4| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7|                                            |            |
                                           | 0| 8| 7| 1| 9| 9| 9| 7| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    125                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                      X                                                   |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |          2                                                               |      3  2.0|
      Basophilic Focus                     | X        X  X     X     X                                                |     31     |
      Eosinophilic Focus                   |                   X                                                      |      5     |
      Hepatodiaphragmatic Nodule           | X                 X  X     X                                             |     12     |
      Inflammation, Chronic                | 1        1  1           1  1                                             |     29  1.1|
      Mixed Cell Focus                     |                                                                          |      1     |
      Bile Duct, Hyperplasia               |          1           1  1  1                                             |     18  1.2|
      Hepatocyte, Vacuolization Cytoplasmic| 2                 1                                                      |      5  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      | 2              1                                                         |     17  1.3|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |                                                                          |      2  3.5|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Aorta, Polyarteritis, Chronic        |                                                                          |      1  2.0|
      Mesenteric Artery, Polyarteritis,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 6| 7| 4| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7|                                            |            |
                                           | 0| 8| 7| 1| 9| 9| 9| 7| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    125                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy, Chronic              |    2  1        1  2  1     1                                             |     41  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Fatty                  |                   1                                                      |     19  1.5|
      Hyperplasia                          |             2     1                                                      |     17  1.6|
      Hypertrophy                          |                                                                          |      2  2.0|
      Karyomegaly                          |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                         2                                                |      4  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  57        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           | 2  4     3        3     4  2                                             |     36  2.6|
      Pars Distalis, Cyst                  |    X  X              X     X                                             |     33     |
      Pars Distalis, Hyperplasia           |                                                                          |     20  2.3|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      | 2  2     2        2     2                                                |     27  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |                   2     1                                                |     10  1.7|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 3                       4                                                |      4  3.0|
      Inflammation, Chronic Active         | 3        1  1     1     2                                                |     20  1.4|
      Duct, Dilatation                     |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                   X                                                      |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 6| 7| 4| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7|                                            |            |
                                           | 0| 8| 7| 1| 9| 9| 9| 7| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    125                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
      Mediastinal, Sinus, Infiltration     |                                                                          |            |
          Cellular, Mononuclear Cell       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sinus, Ectasia                       |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +                                             |  57        |
      Granuloma                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  | 2  2  2  2  1     3  1  2                                                |     50  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Epidermis, Site of Application-No    |                                                                          |            |
          Mass, Erosion                    |    3              3     3                                                |     16  3.0|
      Inguinal, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      2  1.0|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       | 2  2              3  3  2  3                                             |     37  2.2|
      Site of Application-No Mass,         |                                                                          |            |
          Inflammation, Chronic Active     | 2  2              2  3  2  1                                             |     37  2.1|
      Site of Application-No Mass, Ulcer   |                         2  2                                             |      7  1.7|
      Site of Application-No Mass, Ulcer,  |                                                                          |            |
           Multiple                        | 2  4                 3                                                   |     22  3.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Osteopetrosis                        | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |    X     X        X        X                                             |     15     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 6| 7| 4| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7|                                            |            |
                                           | 0| 8| 7| 1| 9| 9| 9| 7| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    125                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrocephalus                        |          2        3        2                                             |     10  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |          1              1                                                |     17  1.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  4.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |    1  1  1  1     1  1  1                                                |     37  1.0|
      Artery, Mediastinum, Polyarteritis,  |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |             2     1     2                                                |      8  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 2           2     2                                                      |      9  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   6        |
      Lens, Cataract                       |                                                                          |      5  4.0|
      Retina, Atrophy                      |                4                                                         |      6  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy, Chronic                 | 3  1  1  1  1     3  1  1                                                |     49  1.6|
      Cortex, Cyst                         | X     X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|             
                             DAY ON TEST   | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|             
                                           | 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                          X     X                              |             
      Eosinophilic Focus                   |                                              X                           |             
      Hepatodiaphragmatic Nodule           |                X                                            X     X      |             
      Inflammation, Chronic                |    1     1  1        1  1     2     1     1           1     1        1   |             
      Mixed Cell Focus                     |                            X                                             |             
      Necrosis, Coagulative                |                                  2  1                                    |             
      Bile Duct, Hyperplasia               | 2  1        1     2  1                          1              2         |             
      Hepatocyte, Vacuolization Cytoplasmic|                   2        1                 1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                    +      |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                              2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                3           1                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            | 4                                                              3         |             
      Epithelium, Hyperplasia              |                                                             2  3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2     1  1  1     1  1  1  1  1  1  1     2  1  1  1     2        1   |             
      Atrium, Thrombosis                   |       X           X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |          1                 3                                1            |             
      Hyperplasia                          |          1                          2        1              1            |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|             
                             DAY ON TEST   | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|             
                                           | 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 4  2     2        2        4           3  2  4              2  3         |             
      Pars Distalis, Cyst                  |                   X     X        X  X                    X  X  X  X      |             
      Pars Distalis, Hyperplasia           |       2  2     2                 2  2                             2      |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2  2              2        2              2                 2  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2           1     1                       3              1     2         |             
      Duct, Dilatation                     |                                           3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Horn, Dilatation                     |                                                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                         +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       4           3  4   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                 +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2                                         3                              |             
      Hematopoietic Cell Proliferation     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  2  2  2     2  1  1     2  2     1  1  2  3     1  2  2     2  2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|             
                             DAY ON TEST   | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|             
                                           | 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |    3  2                    3           3     1                           |             
      Head, Acanthosis                     |                                                                          |             
      Head, Inflammation, Chronic Active   |                                                                          |             
      Head, Ulcer                          |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                       2                  |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       | 2  2  2     2  2           2           2  2  2  3     2  2  2     2     2|             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     | 2  2  2     2  2           2           2  2  2  3     3  1  2     2     2|             
      Site of Application-No Mass, Ulcer   |    2  1     1                          1              4     1            |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        |                3                          4  2  4                 2     2|             
      Tail, Acanthosis                     |                                                       2                  |             
      Tail, Hyperkeratosis                 |                                                       3                  |             
      Tail, Inflammation, Chronic Active   |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X              X        X           X                       X         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |    2              2        3           2     2                 2         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Sciatic, Myelin, Degeneration        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1           2  1           2  1        1     1  2         |             
      Pigmentation, Hemosiderin            |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |    3  1  1  1           1  1  1  1  1  1  1  1        1     1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                                                                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            3                                   2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|             
                             DAY ON TEST   | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|             
                                           | 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2  1  1        2     2  2        1  2  2  3        1  1  2  2  1  1   |             
      Renal Tubule, Hyperplasia            |                                           1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|             
                             DAY ON TEST   | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|             
                                           | 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X     X        X  X              X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X        X     X  X     X        X      |             
      Eosinophilic Focus                   |                                  X              X     X                  |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Chronic                |    1                 2        2  1     2  2           1     1            |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               |    1                                            1        1              2|             
      Hepatocyte, Vacuolization Cytoplasmic|                                              1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                   2                       2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1        1  1  1  1  1  1  1        1  1     2  1  1     2  2     1   |             
      Atrium, Thrombosis                   |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    1                          1  1        2  2           2     2         |             
      Hyperplasia                          |                               2                 2                        |             
      Hypertrophy                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1           1     1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|             
                             DAY ON TEST   | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|             
                                           | 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             3                 4  2           4  3  3  4  3  2     2     2|             
      Pars Distalis, Cyst                  |                X              X        X  X     X  X     X  X  X  X     X|             
      Pars Distalis, Hyperplasia           |       1        2        2  2                                4        2   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                               2  2           2  2     2  2  2     2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      C-Cell, Hyperplasia                  |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
      Inflammation, Chronic Active         | 1                                   2           3                        |             
      Duct, Dilatation                     |                                                                   2     2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Horn, Dilatation                     |                                                    3        3            |             
      Lumen, Hemorrhage                    |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                    3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2     2     2     1  2  2  2  2  2     2  2  4  1  2  2  1  4  2  2  2  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|             
                             DAY ON TEST   | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|             
                                           | 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |    3  3     3     3     3        3                 3                     |             
      Head, Acanthosis                     |                   2                                   2                  |             
      Head, Inflammation, Chronic Active   |                   2                                   2                  |             
      Head, Ulcer                          |                                                       4                  |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       | 2  1  2     2     2  2  2  2  2  2     2  2  2  2  2  2              2   |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     | 2  2  2     2     3  1  3  2  2  2     2  2  3  2  2  2              3   |             
      Site of Application-No Mass, Ulcer   |       4     2                    3                                       |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        | 3  1              3  2  2     4        3  3  4     2  2              3   |             
      Tail, Acanthosis                     |                                                                          |             
      Tail, Hyperkeratosis                 |                                                                          |             
      Tail, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Fibrosis                             |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               X  X           X     X                     |             
      Hemorrhage                           |       2                                                                  |             
      Hydrocephalus                        |                               2  2           3                           |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
      Sciatic, Myelin, Degeneration        |       1                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1              1  1  1     1  1              2  1        1  1     1      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                | 1              1  1  1     1  1  1     1     1  1        1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             3                             2        2           2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|             
                             DAY ON TEST   | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|             
                                           | 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    250                                    | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2  1     1  1     1  1  1  2  2     1  3  2  2  1  1  2  2  1  1     2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 7| 7| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2|                                            |            |
                                           | 8| 6| 9| 9| 1| 0| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    250                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |          X              X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |       X                                                                  |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |             X              X                                             |     11     |
      Eosinophilic Focus                   |                         X                                                |      5     |
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Chronic                | 1                 1  1     1                                             |     23  1.2|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               |                         2  1                                             |     13  1.4|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |       1                 1                                                |      6  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |                   1                                                      |      3  2.7|
      Epithelium, Hyperplasia              |                   2                                                      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy, Chronic              |                   1  1                                                   |     36  1.2|
      Atrium, Thrombosis                   |                         X                                                |      4     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 7| 7| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2|                                            |            |
                                           | 8| 6| 9| 9| 1| 0| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    250                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Fatty                  |          2                                                               |     11  1.6|
      Hyperplasia                          |                                                                          |      6  1.5|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |          1                                                               |      4  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +                                             |  51        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           | 1  1     3  3     4  2  4  4                                             |     29  2.8|
      Pars Distalis, Cyst                  |    X                                                                     |     20     |
      Pars Distalis, Hyperplasia           | 2  3                    3                                                |     15  2.2|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    2     2  2        2  2  2                                             |     22  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Hyperplasia                  |             1                                                            |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                      1                                                   |     10  1.7|
      Duct, Dilatation                     |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Horn, Dilatation                     |                            2                                             |      3  2.7|
      Lumen, Hemorrhage                    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 7| 7| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2|                                            |            |
                                           | 8| 6| 9| 9| 1| 0| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    250                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  |       2     1     2     3                                                |     44  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Epidermis, Site of Application-No    |                                                                          |            |
          Mass, Erosion                    |                2     3                                                   |     14  2.7|
      Head, Acanthosis                     |                                                                          |      2  2.0|
      Head, Inflammation, Chronic Active   |                                                                          |      2  2.0|
      Head, Ulcer                          |                                                                          |      1  4.0|
      Inguinal, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       | 2     2  2  3  1     2                                                   |     38  2.0|
      Site of Application-No Mass,         |                                                                          |            |
          Inflammation, Chronic Active     | 2     2  2  3  2     2                                                   |     38  2.1|
      Site of Application-No Mass, Ulcer   |                                                                          |      9  2.1|
      Site of Application-No Mass, Ulcer,  |                                                                          |            |
           Multiple                        | 4     3  4  4  1     4                                                   |     24  2.9|
      Tail, Acanthosis                     |                                                                          |      1  2.0|
      Tail, Hyperkeratosis                 |                                                                          |      1  3.0|
      Tail, Inflammation, Chronic Active   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Fibrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |             X     X        X                                             |     12     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |          2  3     2        3                                             |     13  2.3|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 7| 7| 4| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2|                                            |            |
                                           | 8| 6| 9| 9| 1| 0| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    250                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Sciatic, Myelin, Degeneration        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |       1  2  1                                                            |     22  1.2|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |    1  1           1     1  1                                             |     34  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    2                    3                                                |      8  2.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Lens, Cataract                       |             4                                                            |      1  4.0|
      Retina, Atrophy                      |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy, Chronic                 | 1  1  2  1  2     2     1  2                                             |     46  1.5|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|             
                                           | 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Parasite Metazoan                    |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                4                                         4               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X                             X                       X            |             
      Clear Cell Focus                     |          X                 X                                             |             
      Eosinophilic Focus                   |                                  X                                   X   |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Inflammation, Chronic                | 1                          1                          2           1     1|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                3                                                         |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  3  1  2  1  1  2  1     1  1  3  1  2  1  3  1  2  1  3  1|             
      Hepatocyte, Degeneration, Cystic     |                2                                               1     2   |             
      Hepatocyte, Vacuolization Cytoplasmic|                2  4                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                          +              +            |             
      Fat, Inflammation, Necrotizing       |                   4                          3              4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1  2  2     4     1     3           1  3                 2            |             
      Artery, Inflammation, Chronic Active |          3                                                               |             
      Artery, Thrombosis                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body, Multiple               |                                                                          |             
      Granuloma                            |                                                                          |             
      Inflammation, Necrotizing            |                2  4                                                      |             
      Epithelium, Hyperplasia              |                2  2           2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Erosion                              |                   2              2                                       |             
      Inflammation, Necrotizing            |                2  3                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Cyst                                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|             
                                           | 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                   2      |             
      Mesenteric Artery, Polyarteritis,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2  2  1  2  2     1  2  2  2     1  2  1  2     1  2  2  2  2  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Atrium, Thrombosis                   |                X                                   X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |          2        1        2  1                             1  2  2  1   |             
      Hyperplasia                          |          2     1                    1              1        2  2  1  1   |             
      Hypertrophy                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2        2              1  2  1     1  2           2  2        1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                         2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 4  4           2  2  4     2  2           2        4     3  1     3  2   |             
      Pars Distalis, Cyst                  |                               X                                   X      |             
      Pars Distalis, Hyperplasia           |       2  2  2           2           2                                    |             
      Pars Distalis, Infarct               |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    2              2        2  2           2                       2  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     1        2                           |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2        2     3  3           3  2  4     4  2           3  4        4   |             
      Mineralization                       |                         1                                                |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  1     2     3  2  3  2  1  1  1  2  2  2  2  2  2  1  2  3  1  3     1|             
      Duct, Dilatation                     |       3        3     3                             4                 3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|             
                                           | 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3  2     2  2  4  2  3  2  2  2  2  1     2  2     1        2  2  3     2|             
      Inflammation, Hemorrhagic            |                                                                          |             
      Epithelium, Hyperplasia              |                               2                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2     2              2  2  3     2  3           3  3        4   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        | X                          X                                             |             
      Interstitial Cell, Hyperplasia       | 2        1           1  1  1     2     1        1  1     1              1|             
      Seminiferous Tubule, Atrophy         | 4        2        2                                      4  4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                 +              +     +     +           +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                                    |             
      Fibrosis                             |       2     2  3                                            2        2   |             
      Necrosis, Coagulative                |                4                                   4                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Cystic                  | 2  2  1  1  2  2  2  2     4  1  1        3  1     4     2  2  1  2  2   |             
      Inflammation, Chronic                |                            4                                             |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Inflammation, Proliferative          |                            4                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-Mass,    |                                                                          |             
           Fibrosis                        |                                  4                                       |             
      Foot, Acanthosis                     |                                                                          |             
      Foot, Hyperkeratosis                 |                                                                          |             
      Foot, Inflammation, Chronic Active   |                                                                          |             
      Inguinal, Acanthosis                 |                                                             1            |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|             
                                           | 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Abscess                     |                                           3                              |             
      Maxilla, Fibrosis                    |                                           4                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X  X              X  X        X                                   X      |             
      Gliosis                              |    3                                                                     |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        | 2  2              2  2        2                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2        1                     |             
      Inflammation, Suppurative            |                                  2                                       |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                1  1           1     1                          1         |             
      Perivascular, Edema                  |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |          X                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |          3                                3  2                       2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2  3        2     2              2              1      |             
      Respiratory Epithelium, Hyperplasia  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia                          |                                                          3               |             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy, Chronic                 | 2  2  3  2  2  3  3  2  2  3  3  2  2  2  2  3  2  2  2  3  2  2  3  3  2|             
      Cortex, Cyst                         |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|             
                                           | 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      4                                                   |             
      Inflammation, Hemorrhagic            |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|             
                             DAY ON TEST   | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|             
                                           | 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                              4                           |             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                 X              X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2                                                           3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Basophilic Focus                     | X                                                  X        X            |             
      Clear Cell Focus                     |             X        X                 X                                 |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X           X                                 |             
      Inflammation, Chronic                |    1                                         1     1              2      |             
      Mixed Cell Focus                     |                   X                                                      |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  1  3  1  2  3  2  3  1     3  2  2  2  2  1  2     1  2  1  1  2  1|             
      Hepatocyte, Degeneration, Cystic     |                2     1                 2                    2            |             
      Hepatocyte, Vacuolization Cytoplasmic|                2                       1        3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +                    +                    +            |             
      Fat, Inflammation, Necrotizing       |                                        4                    3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1  1     1  1                       1  1  1  1     2           2  2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body, Multiple               |                                                                          |             
      Granuloma                            |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                                         |             
      Erosion                              |                3        2                                                |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|             
                             DAY ON TEST   | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|             
                                           | 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Mesenteric Artery, Polyarteritis,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2  1  2  2  2  2  2  2  2  1  2  1  2     2  2  2     2  2  2        2|             
      Inflammation, Chronic Active         |                                                       2                  |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1           1  2  2     2  2           2           2        2           1|             
      Hyperplasia                          |             1     2     2  2           2           2                     |             
      Hypertrophy                          |                2                       2                                1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2           1  2  2  2  2           1  2     1  1  1     4  1           3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  3        2  3           2        2  3  4  1              2  4        2|             
      Pars Distalis, Cyst                  |                   X                          X                           |             
      Pars Distalis, Hyperplasia           |                                     2                    2               |             
      Pars Distalis, Infarct               |                                                                      4   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2        2     2  2        2     2     2        2           2  2     2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2     2           1           3  3        1                        |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  2              3  4  4        2                 4     4  4        4   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2  1  2  2     2  3  2  1  1  2  1     2  1  2  3     2  2  2  1  2  2|             
      Duct, Dilatation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|             
                             DAY ON TEST   | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|             
                                           | 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 4  4  1     1  2  2  2  1  3  3  2  1  1  3  2  2  2     2  3  2  3  4  2|             
      Inflammation, Hemorrhagic            |                                                       4                  |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2              2  2  4        3                 4     3  4        4   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        | X  X        X                                   X                       X|             
      Interstitial Cell, Hyperplasia       |             1           2           1                                1   |             
      Seminiferous Tubule, Atrophy         | 4                 4                                                  4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +        +     +  +  +                       +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |          2           3     3                             4               |             
      Necrosis, Coagulative                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Hyperplasia, Cystic                  | 3  3     2  3  2  4  2  2  2  2  1     4  1     4  1     1  1  2  2  1  3|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Inflammation, Proliferative          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-Mass,    |                                                                          |             
           Fibrosis                        |                                                                          |             
      Foot, Acanthosis                     |                                                                          |             
      Foot, Hyperkeratosis                 |                                                                          |             
      Foot, Inflammation, Chronic Active   |                                                                          |             
      Inguinal, Acanthosis                 |          2                                                               |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|             
                             DAY ON TEST   | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|             
                                           | 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Abscess                     |                                                                          |             
      Maxilla, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X  X           X                          X     X              X         |             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                               3                                          |             
      Hydrocephalus                        | 2  2           2                          3     2              2         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                  +                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                  +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1                                         1        1               |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                  1        1              1  1  1         |             
      Perivascular, Edema                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |       3                                                                  |             
      Inflammation, Chronic Active         |                                                          2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2           3     2                 1  2                    2         |             
      Respiratory Epithelium, Hyperplasia  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                       2                  |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Coagulative                |                                                       2                  |             
      Nephropathy, Chronic                 | 3  2  2  2  3  3  2  4  3  3  2  3  2  3  2  2  3  3     3  3  2  2  2  3|             
      Cortex, Cyst                         |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|             
                             DAY ON TEST   | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|             
                                           | 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Hemorrhagic            |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 5| 7| 6| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3|                                            |            |
                                           | 6| 2| 6| 4| 9| 9| 8| 6| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Parasite Metazoan                    |                   X                                                      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |       X                    X                                             |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |             X                                                            |      7     |
      Clear Cell Focus                     |                                                                          |      5     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |       X                                                                  |      4     |
      Inflammation, Chronic                | 1     1              1                                                   |     12  1.2|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |    2  1  2  2  1  2  2  1  3                                             |     56  1.8|
      Hepatocyte, Degeneration, Cystic     |                            2                                             |      8  1.8|
      Hepatocyte, Vacuolization Cytoplasmic|    3                                                                     |      6  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                                                               |   9        |
      Fat, Inflammation, Necrotizing       |    3                                                                     |      6  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |                1  1        2                                             |     23  1.6|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Artery, Thrombosis                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body, Multiple               |    2                                                                     |      1  2.0|
      Granuloma                            |    3                                                                     |      1  3.0|
      Inflammation, Necrotizing            |    3           4                                                         |      4  3.3|
      Epithelium, Hyperplasia              |    2           2        3                                                |      6  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Erosion                              |          2                                                               |      5  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 5| 7| 6| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3|                                            |            |
                                           | 6| 2| 6| 4| 9| 9| 8| 6| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Necrotizing            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |                                                                          |      1  2.0|
      Mesenteric Artery, Polyarteritis,    |                                                                          |            |
           Chronic                         |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy, Chronic              | 1  1  2  2  2  1  2     2  2                                             |     51  1.8|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Fatty                  |    2                    1  2                                             |     21  1.6|
      Hyperplasia                          |                            2                                             |     15  1.6|
      Hypertrophy                          |                2     2     2                                             |      7  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |    2        1           2  3                                             |     28  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +                                             |  55        |
      Hyperplasia                          |                         2                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |    2        3  4  4        1                                             |     30  2.7|
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           | 2                    2                                                   |      9  2.0|
      Pars Distalis, Infarct               |                                                                          |      1  4.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    2        2  2  2                                                      |     23  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |                                                                          |      8  1.9|
      Follicle, Cyst                       |             X                                                            |      1     |
      Follicular Cell, Hyperplasia         |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 5| 7| 6| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3|                                            |            |
                                           | 6| 2| 6| 4| 9| 9| 8| 6| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    2        4           3  4                                             |     26  3.2|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 2  1  1  2  2  1  2  2  2  3                                             |     54  1.8|
      Duct, Dilatation                     |                                                                          |      5  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 2  3  2  2  4  4  3  1  4  2                                             |     52  2.3|
      Inflammation, Hemorrhagic            |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    3        4           3  4                                             |     24  2.9|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Polyarteritis                        |             X              X                                             |      9     |
      Interstitial Cell, Hyperplasia       | 1  1        1  1     1     1                                             |     21  1.1|
      Seminiferous Tubule, Atrophy         |             4              2                                             |     10  3.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                 +                                             |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             |                            2                                             |     10  2.5|
      Necrosis, Coagulative                |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  M  M                                             |  56        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 5| 7| 6| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3|                                            |            |
                                           | 6| 2| 6| 4| 9| 9| 8| 6| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |    2        2  2  2     3  3                                             |     46  2.1|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Inflammation, Proliferative          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dermis, Site of Application-Mass,    |                                                                          |            |
           Fibrosis                        |                                                                          |      1  4.0|
      Foot, Acanthosis                     |                            4                                             |      1  4.0|
      Foot, Hyperkeratosis                 |                            4                                             |      1  4.0|
      Foot, Inflammation, Chronic Active   |                            2                                             |      1  2.0|
      Inguinal, Acanthosis                 |                                                                          |      2  1.5|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Maxilla, Abscess                     |                                                                          |      1  3.0|
      Maxilla, Fibrosis                    |             4                                                            |      2  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |    X           X  X                                                      |     15     |
      Gliosis                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |    3           3  2                                                      |     14  2.2|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |       1        1  1                                                      |      8  1.1|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                            1                                             |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |    1  1  1     1  1     1  1                                             |     17  1.0|
      Perivascular, Edema                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fungus                               |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 5| 7| 6| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3|                                            |            |
                                           | 6| 2| 6| 4| 9| 9| 8| 6| 0| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      5  2.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |     12  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   3        |
      Lens, Cataract                       |                      4                                                   |      1  4.0|
      Retina, Atrophy                      |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 2  3     2  4  3  2  2  4  3                                             |     58  2.5|
      Cortex, Cyst                         |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Hemorrhagic            |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|             
                                           | 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    32 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X     X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                    X              X                                    |             
      Clear Cell Focus                     | X                                   X                                    |             
      Eosinophilic Focus                   | X                                                     X                  |             
      Hepatodiaphragmatic Nodule           |                                  X                             X         |             
      Hyperplasia, Nodular                 |                                  3                                       |             
      Inflammation, Chronic                | 1  1              1     1  1        2     1  1              2  2        1|             
      Mixed Cell Focus                     | X                                   X                                    |             
      Necrosis, Coagulative                |                                                                      2   |             
      Bile Duct, Hyperplasia               | 2     2  2  3  3  2  1  1  1     3  2     1  1  2  1     1     2  3  2  1|             
      Hepatocyte, Degeneration, Cystic     |                                  2  1                             3      |             
      Hepatocyte, Vacuolization Cytoplasmic|    2     3        2                          1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                       +        +  +        +     +            |             
      Fat, Inflammation, Necrotizing       |       3                                   4  3        4     4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2  1        2  2     1        1  1  1              1              1  1   |             
      Acinus, Hyperplasia, Nodular         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                           2                              |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             2            |             
      Inflammation, Necrotizing            |                                              4                           |             
      Mineralization                       |    4                                                                     |             
      Epithelium, Hyperplasia              |                                              2              2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          2                                                               |             
      Inflammation, Necrotizing            |             3                                         1                  |             
      Mineralization                       |    4                                                                     |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|             
                                           | 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    32 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    4                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  3  3  2  2  2  2  1     1  2           1  1  2  1  2  1  2  2  2  1  2|             
      Inflammation, Suppurative            |             2                                                            |             
      Mineralization                       |    3                                                                     |             
      Atrium, Thrombosis                   |                                                                          |             
      Valve, Bacterium                     |             X                                                            |             
      Valve, Inflammation, Chronic Active  |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |    2           2  1                                   1           2      |             
      Hyperplasia                          |    2  2           2           2     2        2        2                  |             
      Hypertrophy                          |                                                       2           3      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3           1              1              2     1  1           1  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    4                                                        2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3     3  2     2  3  4  4     2  2  2  3        4           3  3     2   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2     2                 2                          2  2              2|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2        2     2  2     2     2              2              2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    3                                                                     |             
      Follicle, Cyst                       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  2  2  2  3     2              4                       4        4  3|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|             
                                           | 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    32 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
      Inflammation, Chronic Active         | 3  1  2  1     3     2  1  1  1  1  2  2  4     2  1  2     2  2     2  1|             
      Duct, Dilatation                     |             3                 3                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2  4  3     2  3  2  2     3     2  3  2  3  2     2  2  3  3  2  2  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  2  2  2  3     2                                3     3        3   |             
      Mineralization                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |       X           X  X                       X                           |             
      Interstitial Cell, Hyperplasia       |    1     2     1  1        1  1  1                 1  1           1  1   |             
      Seminiferous Tubule, Atrophy         |    4  4                                                              4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3  4                                       |             
      Myelofibrosis                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +                 +                                +      |             
      Inguinal, Sinus, Ectasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Red Pulp, Atrophy                    |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  | 2  2  2     1  2  2  2  3        3  1  3  3  3  1     1     4  2     1   |             
      Inflammation, Chronic Active         |                                              3                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-No Mass, |                                                                          |             
           Fibrosis                        |                                                                          |             
      Foot, Ulcer                          |                                                                          |             
      Inguinal, Acanthosis                 |             2                                                            |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |             2                                                            |             
      Inguinal, Ulcer                      |             4                                                            |             
      Site of Application-No Mass,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|             
                                           | 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    32 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Acanthosis                       |             1                                                            |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     |             1                       1                                    |             
      Tail, Inflammation, Chronic Active   |                                        3                                 |             
      Tail, Ulcer                          |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X           X  X  X              X  X  X  X              X         |             
      Hemorrhage                           |             2                                   2                        |             
      Hydrocephalus                        |       2           3  3  2              3  2  2  2              2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      1                    1                              |             
      Mineralization                       |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia     | 3                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                | 1                    1  1           1     1                       1     1|             
      Fat, Mediastinum, Atrophy            |             4                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                 2                             2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   1           2     2           1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
      Cyst Epithelial Inclusion            |    X                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |             3                                                            |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                    2                     |             
      Nephropathy, Chronic                 | 2  4  3  2  3  2  3  3  2  2  2  3  3  2  2  2  2     3  2  4  2  2  3  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|             
                                           | 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                  X     X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                      4                                                   |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                                   X     X        X               |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                 X                        |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic                | 1  1  1        1                    1  1  1        1     1        1      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1     1  1  1  3     2     2  1  1  1  2     2  1  2  2  3  2  1  3   |             
      Hepatocyte, Degeneration, Cystic     |             2                                                            |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +     +              +                                 |             
      Fat, Inflammation, Necrotizing       |                         4              4                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2  1                 1  1     2                          1  2     3   |             
      Acinus, Hyperplasia, Nodular         |                                                 3                        |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Necrotizing            |                      3                                               4   |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                      2                                               2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                   3                                                  1   |             
      Inflammation, Necrotizing            |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|             
                                           | 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1  2  1  2  2     2  2  2  2  2  1     1  2  2  1  2  2  2  1  2  2   |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                      X   |             
      Valve, Bacterium                     |                                                                          |             
      Valve, Inflammation, Chronic Active  |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |       1              1           1     1  1              2              1|             
      Hyperplasia                          |                            2           1        1     1  2     1         |             
      Hypertrophy                          |                      2                    2                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2        2     2  2                 1     1           2  2     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                      2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2     2  4     4     2  2  4  4  2        3  3        3  2     3        3|             
      Pars Distalis, Cyst                  |                                                 X        X               |             
      Pars Distalis, Hyperplasia           | 2     2                             2  2        2                    2   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |          2     2     2  2  2  2           2  2        2  2     2        2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1                          3                          2  2  2         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4              3  3  3              3     4     3     3  2     4  3|             
      Inflammation, Chronic Active         |                                        2                                 |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|             
                                           | 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                             4                                    |             
      Inflammation, Chronic Active         | 1  1  2  1  2  3     1  2  1  2  4  2  1  3  2  2  1  3  2  2  1  1     1|             
      Duct, Dilatation                     |                                  4                    3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  3  1  2  1  2  1     2  2  2  3  1  2  2  3  1  1  2  3  2  2  2     2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4              3  3  3                    3     3     3        3  3|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                                          |             
      Interstitial Cell, Hyperplasia       |          1  1     1           1  1     1  1        2           1         |             
      Seminiferous Tubule, Atrophy         |                      4                                4        2     4  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      4                                                   |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +     +                             +     +        +   |             
      Inguinal, Sinus, Ectasia             |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Necrosis, Coagulative                |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2     2     2  1  3     2     2        2  3        2  3     1     1  3|             
      Inflammation, Chronic Active         |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-No Mass, |                                                                          |             
           Fibrosis                        |       4                                                                  |             
      Foot, Ulcer                          |                                                                          |             
      Inguinal, Acanthosis                 |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           | 1                                                                        |             
      Inguinal, Ulcer                      |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|             
                                           | 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Acanthosis                       |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
      Tail, Inflammation, Chronic Active   |                                                                          |             
      Tail, Ulcer                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X     X     X        X  X           X        X  X               |             
      Hemorrhage                           |          2                       2                                       |             
      Hydrocephalus                        |          2     2     2        3  3           2        2  2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1                                      1              2            |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |    1  1                    1        1     1  1  1     1  1     1     1  1|             
      Fat, Mediastinum, Atrophy            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      4                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2                       2     3                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
      Cyst Epithelial Inclusion            |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                         2                                                |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy, Chronic                 | 2  2  3  3  2  3     3  2  2  2  2  2  1  2  2  3  2  3  3  3  2  2  3  4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3|                                            |            |
                                           | 6| 0| 0| 4| 6| 6| 1| 1| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    32 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    | X     X                                                                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                      X                                                   |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      7     |
      Clear Cell Focus                     |                   X                                                      |      4     |
      Eosinophilic Focus                   |       X                                                                  |      4     |
      Hepatodiaphragmatic Nodule           |       X                    X                                             |      5     |
      Hyperplasia, Nodular                 |                                                                          |      1  3.0|
      Inflammation, Chronic                | 1              1     1                                                   |     24  1.1|
      Mixed Cell Focus                     |    X                                                                     |      3     |
      Necrosis, Coagulative                |          2                                                               |      2  2.0|
      Bile Duct, Hyperplasia               | 1  1  2  3     1  1  1  2  2                                             |     49  1.7|
      Hepatocyte, Degeneration, Cystic     |       1                    1                                             |      6  1.7|
      Hepatocyte, Vacuolization Cytoplasmic|       2              2     2                                             |      7  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Fat, Inflammation, Necrotizing       |                                                                          |      7  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |    3              2                                                      |     21  1.5|
      Acinus, Hyperplasia, Nodular         |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Necrotizing            |                                                                          |      3  3.7|
      Mineralization                       |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |       3        3                                                         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3|                                            |            |
                                           | 6| 0| 0| 4| 6| 6| 1| 1| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    32 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                          |      3  2.0|
      Inflammation, Necrotizing            |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Necrosis, Coagulative                |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy, Chronic              | 1  2  1     2  1  2  2  2  1                                             |     52  1.7|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
      Valve, Bacterium                     |                                                                          |      1     |
      Valve, Inflammation, Chronic Active  |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                   X                                                      |      1     |
      Degeneration, Fatty                  |       2     1     2  1  1                                                |     17  1.4|
      Hyperplasia                          |    2  1              1  1                                                |     17  1.6|
      Hypertrophy                          |          1                                                               |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |    1  2  1           1     2                                             |     22  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                      3                                                   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |       2                                                                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |       2     2  4  1     4  3                                             |     36  2.8|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |    1     2        3  2                                                   |     16  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |       2     2  2        2                                                |     24  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |                   1                                                      |      7  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3|                                            |            |
                                           | 6| 0| 0| 4| 6| 6| 1| 1| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    32 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    4  3              4                                                   |     25  3.2|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  3.0|
      Inflammation, Chronic Active         | 1  1  1  1  2  1  1  2  2  2                                             |     53  1.7|
      Duct, Dilatation                     |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         | 2     2  2  3     2  2  3  2                                             |     52  2.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    4  3              2  2                                                |     22  2.9|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Polyarteritis                        |                                                                          |      4     |
      Interstitial Cell, Hyperplasia       | 1                          1                                             |     22  1.1|
      Seminiferous Tubule, Atrophy         |                                                                          |      8  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  3.7|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |  10        |
      Inguinal, Sinus, Ectasia             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |       4              3                                                   |      3  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Necrosis, Coagulative                |          4                                                               |      1  4.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3|                                            |            |
                                           | 6| 0| 0| 4| 6| 6| 1| 1| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    32 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  +  +  +  +  M  +                                             |  53        |
      Hyperplasia, Cystic                  |          2  2  4  2  2                                                   |     37  2.1|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dermis, Site of Application-No Mass, |                                                                          |            |
           Fibrosis                        |                                                                          |      1  4.0|
      Foot, Ulcer                          |    4                                                                     |      1  4.0|
      Inguinal, Acanthosis                 |                                                                          |      1  2.0|
      Inguinal, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      2  1.5|
      Inguinal, Ulcer                      |                                                                          |      1  4.0|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       |                                                                          |      1  1.0|
      Site of Application-No Mass,         |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      2  1.0|
      Tail, Inflammation, Chronic Active   |                                                                          |      1  3.0|
      Tail, Ulcer                          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                X        X                                                |     19     |
      Hemorrhage                           |                                                                          |      4  2.0|
      Hydrocephalus                        |                2        2                                                |     19  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      5  1.2|
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                            2                                             |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |       1        1  1  1                                                   |     23  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 6| 6| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3|                                            |            |
                                           | 6| 0| 0| 4| 6| 6| 1| 1| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    32 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fat, Mediastinum, Atrophy            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      4  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    2     2  2              2                                             |     11  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |             3                                                            |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 2  3  4  2  2  2  3  3  2  4                                             |     58  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|             
                                           | 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X  X     X                 X     X        X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2     2                                                            |             
      Basophilic Focus                     |                   X                                                      |             
      Clear Cell Focus                     |          X        X        X                                             |             
      Eosinophilic Focus                   |       X                                      X  X                        |             
      Hepatodiaphragmatic Nodule           |    X                                   X  X                              |             
      Inflammation, Chronic                |             1  1                    1     1     1           1  1         |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Coagulative                |                               4                                          |             
      Bile Duct, Hyperplasia               | 2  3  2  2  2  1  2  3  3  2  2  1  1  1  1  3  1  1  2     1  1  2     3|             
      Hepatocyte, Degeneration, Cystic     | 3                    2                                                   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +              +     +     +                             +      |             
      Fat, Inflammation, Necrotizing       | 4        3                          3                             4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  3           1     1                    1           1        1     1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Necrotizing            |                         4                    3                           |             
      Epithelium, Hyperplasia              |                         3                    2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Glandular               |                                                                          |             
      Inflammation, Necrotizing            | 3                                                                        |             
      Necrosis, Coagulative                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2  2  1  3        2  2  2  1  2  1  2  1  2  2  2  1  1  3  1   |             
      Atrium, Thrombosis                   |                      X                                                   |             
      Endocardium, Atrium, Proliferation   |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|             
                                           | 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 2           2     1  2                       2           3               |             
      Hyperplasia                          |       2  1        2     1                             1                  |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        1        2     1  1                 4           1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                                                                          |             
      Pars Distalis, Angiectasis           | 2  4  2     4     4     2  2  2  3                 4  2  4           1   |             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           | 3        2           2        2              2        3              2   |             
      Pars Distalis, Infarct               |                                        4                                 |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2  2  2  2  2     2        2  2  2     2     2     2  2  2           2   |             
      Pars Intermedia, Hyperplasia         |                                              2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      C-Cell, Hyperplasia                  | 2                                      1     2              2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  3  3           3     2     3           3                    2  2  3|             
      Granuloma Sperm                      |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2     2     2  2  1     2  2  1  2  2  1  2  2  2  2  1  3  1     2  2|             
      Duct, Dilatation                     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  3  1  1  3  2  3  2  2  2  1  2  1  2  2  2     3  1  2     1  1      |             
      Inflammation, Hemorrhagic            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  4  2              3  3        3           4                    3     3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |             X     X              X                       X               |             
      Interstitial Cell, Hyperplasia       | 2  1        1  1  1     1           1     1  2              1            |             
      Seminiferous Tubule, Atrophy         | 4  4                             4           4                       4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|             
                                           | 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               4                                      4   |             
      Myelofibrosis                        | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +              +  +     +  +     +     +                          +|             
      Mediastinal, Sinus, Hemorrhage       |                               4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                      X                                                   |             
      Fibrosis                             |                      2                       3                          2|             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  3  2     2  2  1  2     2        2  1     4  2  3        2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-No Mass, |                                                                          |             
           Fibrosis                        |                                                                          |             
      Inguinal, Acanthosis                 |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Abscess                     |                                                                          |             
      Maxilla, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X        X                    X                 X     X               |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |    4              2              2                 3     3               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                         +                          +                     |             
      Sciatic, Myelin, Degeneration        |                         1                                                |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                          +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|             
                                           | 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                         2                                                |             
      White Matter, Degeneration           |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1                          1  1                           |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |    1              1     1  1        1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                            1               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                         2  2              3                             2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Lens, Cataract                       |                                                          4               |             
      Retina, Atrophy                      |                                                          4               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
      Abscess                              |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
      Nephropathy, Chronic                 | 2  2  2  3  3  1  3  3  2  3  1  4  2  2  2  4  2  2  3  3  2  2  2  1  3|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|             
                                           | 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X     X  X                       X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                        X                             X  X|             
      Clear Cell Focus                     |                                                                         X|             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X           X                          X               |             
      Inflammation, Chronic                |          1        1     1  1        1  1     1                 2         |             
      Leukocytosis                         |          2                                                               |             
      Necrosis, Coagulative                |                2                                                         |             
      Bile Duct, Hyperplasia               | 1  3     2  3  1  1  2  3  1  2  1  2  2     2  1  1  3  1  3  1  3     3|             
      Hepatocyte, Degeneration, Cystic     |                                              2  1           1            |             
      Hepatocyte, Vacuolization Cytoplasmic| 3           3                                               1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +                                            +           +      |             
      Fat, Inflammation, Necrotizing       |          4                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             3  2  3  2  2                             2     2     2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               2                                          |             
      Inflammation, Necrotizing            |    4                                            4                    2   |             
      Epithelium, Hyperplasia              |    2                          3     2           3                    2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                       2                  |             
      Hyperplasia, Glandular               |                                                    2                     |             
      Inflammation, Necrotizing            |    4                                                                     |             
      Necrosis, Coagulative                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  1  2  2  2  1  2  2     2  2  2  2  1  2  2     1  2  2  2  2  2  2|             
      Atrium, Thrombosis                   |                                                                          |             
      Endocardium, Atrium, Proliferation   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|             
                                           | 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |          2  2                 2     1  2        2     2     2        2  1|             
      Hyperplasia                          | 2        2     2                 1  1  4  1  1  1           2        2   |             
      Hypertrophy                          |             2     2  1  1                                               1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1     1     1        1     2     1           2           2        2  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                         X                                                |             
      Pars Distalis, Angiectasis           | 2           3        4           2  4        4  2              4     3  3|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2  2           2     3  2                                      2      |             
      Pars Distalis, Infarct               |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2           2  2     2           2  2        2  2              2  2  2  2|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      C-Cell, Hyperplasia                  |             1                 1                 1     2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3     3  4        3  4     3        4        2                 3  2   |             
      Granuloma Sperm                      |                         2                                                |             
      Fat, Necrosis                        |                                                                   4      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2     1  1  4  2  2  2  2  2  3  2  2  1  1  2  2  1  2     3  2  2  1  4|             
      Duct, Dilatation                     |             4     4           3              3                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1           3  2  1  3  2  1  3  1     2  1  3  3  1  2  2  2  4  2  3  2|             
      Inflammation, Hemorrhagic            |                                     4                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3     3  4        3  3     3        3        2                 3  2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                               X                 X                    X   |             
      Interstitial Cell, Hyperplasia       |                1  1        1        1              1        1  1         |             
      Seminiferous Tubule, Atrophy         |    4     4  4        4        3                 2                    3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|             
                                           | 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       4  4     4                                                         |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +                                         +           +     +|             
      Mediastinal, Sinus, Hemorrhage       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        3                                 |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |          2                                      2                        |             
      Hematopoietic Cell Proliferation     |       3                                                                  |             
      Necrosis, Coagulative                |             4                                                            |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  2        2        1        4  1           3  4     1  1  1  2  2  3  4|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-No Mass, |                                                                          |             
           Fibrosis                        |                               4                                          |             
      Inguinal, Acanthosis                 |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Abscess                     |                                                                      2   |             
      Maxilla, Fibrosis                    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Compression                          | X           X                       X        X                 X         |             
      Hemorrhage                           |    2                                                                     |             
      Hydrocephalus                        |             2                       2        2                 3         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Sciatic, Myelin, Degeneration        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|             
                                           | 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    63 MG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              1  1                        |             
      Alveolar Epithelium, Hyperplasia     |                         4     4                                         3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |             1  1  1           1     1        1        1  1  1           1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          3                       3                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     | +                    +                                                   |             
      Lens, Cataract                       | 4                    4                                                   |             
      Retina, Atrophy                      | 4                    4                                                   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Nephropathy, Chronic                 | 2  2  1  3  3  3  2  2  3  2  4  3  2  3  1  2  4  3  2  2  3  2  2  4  2|             
      Pigmentation, Hemosiderin            |          3                                                               |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 4| 5|                                               |            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 1| 1| 5| 8|                                               |            |
                                           | 1| 2| 9| 0| 1| 6| 0| 6| 6|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      A     |
    63 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Parasite Metazoan                    |             X                                                            |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  59        |
      Parasite Metazoan                    |          X                                                               |     11     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |                                                                          |      4     |
      Clear Cell Focus                     |                                                                          |      4     |
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                         X                                                |      7     |
      Inflammation, Chronic                |       1  1           1  1                                                |     19  1.1|
      Leukocytosis                         |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      2  3.0|
      Bile Duct, Hyperplasia               | 2  2  1  2  2  3  1     1                                                |     53  1.8|
      Hepatocyte, Degeneration, Cystic     |    1                                                                     |      6  1.7|
      Hepatocyte, Vacuolization Cytoplasmic|    2                                                                     |      5  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |  11        |
      Fat, Inflammation, Necrotizing       |       4                                                                  |      6  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  59        |
      Acinus, Atrophy                      |             2        1  2                                                |     19  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Necrotizing            |    4           3  4                                                      |      8  3.5|
      Epithelium, Hyperplasia              |    2              2                                                      |      9  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  59        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Glandular               |                                                                          |      1  2.0|
      Inflammation, Necrotizing            |    3                                                                     |      3  3.3|
      Necrosis, Coagulative                |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 4| 5|                                               |            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 1| 1| 5| 8|                                               |            |
                                           | 1| 2| 9| 0| 1| 6| 0| 6| 6|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      A     |
    63 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy, Chronic              | 2  2  2  2  2  1  2                                                      |     52  1.8|
      Atrium, Thrombosis                   |                                                                          |      1     |
      Endocardium, Atrium, Proliferation   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +                                                |  59        |
      Degeneration, Fatty                  |    2           3  2     1                                                |     20  1.9|
      Hyperplasia                          | 1  2                    2                                                |     19  1.6|
      Hypertrophy                          |                   2                                                      |      6  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Hyperplasia                          | 1  2  2  1     1                                                         |     22  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M                                                |  53        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |    2                                                                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |  58        |
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |            |
           Cyst                            |                                                                          |      1     |
      Pars Distalis, Angiectasis           |    2  2  4  2     2     2                                                |     29  2.8|
      Pars Distalis, Cyst                  |    X                 X                                                   |      3     |
      Pars Distalis, Hyperplasia           | 3           2                                                            |     15  2.3|
      Pars Distalis, Infarct               |                                                                          |      1  4.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    2  2  2        2     2                                                |     32  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  59        |
      Hyperplasia                          |       4                                                                  |      1  4.0|
      C-Cell, Hyperplasia                  |                                                                          |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy                              |    2     3  4  2  2     2                                                |     27  2.8|
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  M  +  +                                                |  58        |
      Inflammation, Chronic Active         | 1  1     3  2  1     2  2                                                |     51  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 4| 5|                                               |            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 1| 1| 5| 8|                                               |            |
                                           | 1| 2| 9| 0| 1| 6| 0| 6| 6|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      A     |
    63 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Dilatation                     |                                                                          |      5  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +                                                |  59        |
      Inflammation, Chronic Active         | 1  2  2  2  1     3  2  3                                                |     50  2.0|
      Inflammation, Hemorrhagic            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +                                                |  59        |
      Atrophy                              |             4  2  3     3                                                |     23  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Polyarteritis                        | X                 X                                                      |      9     |
      Interstitial Cell, Hyperplasia       | 1     1                                                                  |     19  1.1|
      Seminiferous Tubule, Atrophy         |    4              3                                                      |     14  3.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  59        |
      Hyperplasia                          |                                                                          |      5  4.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |  16        |
      Mediastinal, Sinus, Hemorrhage       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +                                                |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |                                                                          |      5  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Necrosis, Coagulative                |                4                                                         |      2  4.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +                                                |  58        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  M  +                                                |  54        |
      Hyperplasia, Cystic                  | 1  4  4  4     1  4                                                      |     37  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Dermis, Site of Application-No Mass, |                                                                          |            |
           Fibrosis                        |                                                                          |      1  4.0|
      Inguinal, Acanthosis                 |    2                                                                     |      1  2.0|
      Inguinal, Inflammation, Chronic      |                                                                          |            |
          Active                           |    1                                                                     |      1  1.0|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 4| 5|                                               |            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 1| 1| 5| 8|                                               |            |
                                           | 1| 2| 9| 0| 1| 6| 0| 6| 6|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      A     |
    63 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Maxilla, Abscess                     |                                                                          |      1  2.0|
      Maxilla, Fibrosis                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  58        |
      Compression                          |                                                                          |     10     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      9  2.6|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
      Sciatic, Myelin, Degeneration        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  2.0|
      White Matter, Degeneration           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Inflammation, Chronic Active         |                         1                                                |      6  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  3.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |    1     1  1  1        1                                                |     20  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  59        |
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1           3                                                            |      8  2.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Lens, Cataract                       |                                                                          |      3  4.0|
      Retina, Atrophy                      |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 4| 5|                                               |            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 1| 1| 5| 8|                                               |            |
                                           | 1| 2| 9| 0| 1| 6| 0| 6| 6|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      A     |
    63 MG/KG                               | 7| 7| 7| 7| 7| 7| 7| 7| 8|                                               |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  59        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Nephropathy, Chronic                 | 3  4  2  3  2  3  4  2  3                                                |     59  2.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Cortex, Cyst                         | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +                                                |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|             
                                           | 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    125                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X        X                 X                    X                 X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X        X  X     X     X           X                        |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                2                                                         |             
      Eosinophilic Focus                   |          X                                                               |             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Inflammation, Chronic                |    2           1                       1        1           1     1  1   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  3  1  2  2  2  2  2  1  3  1     3  2  1  1  2  2     2        1|             
      Hepatocyte, Degeneration, Cystic     | 1        3        1  1        1           2                              |             
      Hepatocyte, Vacuolization Cytoplasmic|                         1                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Fat, Inflammation, Necrotizing       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Acinus, Atrophy                      | 2        1           1                       1  2        2  2     1      |             
      Acinus, Hyperplasia, Nodular         |                         2                 2                              |             
      Artery, Inflammation, Chronic Active |                                        3        2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |    4                                                                     |             
      Epithelium, Hyperplasia              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Thrombosis        | X                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  1  2  2  2  2  2  2  2  2  2  1  3  1  2  2  2  2  2  2  1  2  2  1  2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1  1     1  1  1  1  2        2           2  2  2  1                    1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|             
                                           | 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    125                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 1     2  1  2     1     1                 2  2  2              2        1|             
      Hypertrophy                          | 2                             2  2                                       |             
      Karyomegaly                          |          1                                                               |             
      Necrosis, Coagulative                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2  2           1     1  1           2  1                    2     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2  4  3  1  2  3     3  2  2  3           2  4  3     2  3     3  4     4|             
      Pars Distalis, Cyst                  |    X                                                                     |             
      Pars Distalis, Hyperplasia           |                   2     2           3  2           2  2     2        2   |             
      Pars Distalis, Infarct               |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2  2  2  2  2  2     2  2     2           2  2  2        2        2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                  1  1              2                 1  2|             
      Follicle, Cyst                       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4        4  4     3     3  2     3        3     4     4  3               |             
      Fibrosis                             |          2                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                             +                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  1  1  2  2  2     3  2     2  2  1  1  2  2  2  1  3  2  1  1  2  1  1|             
      Duct, Dilatation                     |                                                 3                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic Active         | 2  3  3  2  3  2  2  2     1  3     1  2  1  3  3  2  3  3  1  2  3  1  3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4        4        3     3        3              3     4                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |             X                 X              X                           |             
      Interstitial Cell, Hyperplasia       |          1  1     1  1  1           1  1  1        1           1     1   |             
      Seminiferous Tubule, Atrophy         |          4  4     2     4                 2                          4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|             
                                           | 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    125                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            4                          4                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                      3                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             3                 2  3                                       |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3  2  2  4  4  2  2  1  1  2  2        1  4  2     1  3     2  2     2|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Proliferative          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-No Mass, |                                                                          |             
           Fibrosis                        |                                                                          |             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |                                                                          |             
      Neck, Ventral, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                  3                                       |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                      2              1           1     1        2         |             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     |                      2                          1     2        2         |             
      Site of Application-No Mass, Ulcer   |                      2                                                   |             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        |                                                       4                  |             
      Tail, Acanthosis                     | 3                                                                        |             
      Tail, Hyperkeratosis                 | 4                                                                        |             
      Tail, Inflammation, Chronic Active   | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   X                                                      |             
      Femur, Cyst                          |                                                                          |             
      Maxilla, Abscess                     |                                                                          |             
      Maxilla, Fibrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|             
                                           | 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    125                                    | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X           X                             X  X                 X     X|             
      Hydrocephalus                        |    3           2                             2  2                 3     3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       1              1   |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |    1        1           1              1        1        1  1           1|             
      Mediastinum, Fibrosis                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                1     3           2                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                2  3     2|             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  2  3  3  3  4  3  3  2  3  2  2  1  2  3  3  4  2  2  2  3  3  1  2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Hemorrhagic            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|             
                                           | 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                               X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X  X                             X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X  X        X                          X|             
      Clear Cell Focus                     |                                                                   X      |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |    1        1  1        1     1     2           1                       1|             
      Mixed Cell Focus                     |                                     X                                    |             
      Necrosis, Coagulative                |       1                                2                                 |             
      Bile Duct, Hyperplasia               | 1  1  3  1  1  1  3  2     2  1  2  2     2  2  1  3  1     1  2  2  1  2|             
      Hepatocyte, Degeneration, Cystic     |                      2              2                                    |             
      Hepatocyte, Vacuolization Cytoplasmic|                            2        3  3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +           +         |             
      Fat, Inflammation, Necrotizing       |                                                    4           4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                               1                                          |             
      Acinus, Atrophy                      |    1           1  1              1           1              1            |             
      Acinus, Hyperplasia, Nodular         |                                     3                                    |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |          2                             4                                 |             
      Epithelium, Hyperplasia              |          3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Mesenteric Artery, Thrombosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    1  2  2     1  2  2  1  2  1  1  2  2  1  2     2  1  1  2  1  2  2  2|             
      Atrium, Thrombosis                   |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |       1           2        1        2     1  2     2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|             
                                           | 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |       2     1     2  2     1     1  2        2     2              2      |             
      Hypertrophy                          |                   2                 2                                    |             
      Karyomegaly                          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1        1                       1  1        1                    2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  M  +|             
      Cyst                                 |                                                       X                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             4     2        4     4  2  4  2  2     2     4  3  3     4  3|             
      Pars Distalis, Cyst                  | X        X                                      X                        |             
      Pars Distalis, Hyperplasia           | 2  2  2        2     1  2                 3     2     2                  |             
      Pars Distalis, Infarct               |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |             2     2        2     2  2  2  2  2     2     2  2  2     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      2                                            2      |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                       3        3        3              4  2   |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  2  2  2  1  1  2  2  2  2  1  2  2  2  2  2  1  3  2  1  2  2  2  1  2|             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       3                                                                  |             
      Inflammation, Chronic Active         | 1  1  2  2  3  1  3  2  1  2  1  3  2  4  2  3     1  2  3  3  3  2  4  3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                3        3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                     X  X                                 |             
      Interstitial Cell, Hyperplasia       | 1  1  1        1        1     1                 1     1           1     1|             
      Seminiferous Tubule, Atrophy         |                                                                   3  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|             
                                           | 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       4                 4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +                                +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2           2                 2              2                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Coagulative                | 4                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Developmental Malformation           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +|             
      Hyperplasia, Cystic                  |       2  3  3     2  1     2     4  4     2  3     2     2  2        2  3|             
      Inflammation, Chronic Active         |                                  3                                       |             
      Inflammation, Proliferative          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Site of Application-No Mass, |                                                                          |             
           Fibrosis                        |                                                                          |             
      Epidermis, Site of Application-No    |                                                                          |             
          Mass, Erosion                    |                                                                   3      |             
      Neck, Ventral, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Site of Application-No Mass,         |                                                                          |             
          Acanthosis                       |                1                             1              2     2     2|             
      Site of Application-No Mass,         |                                                                          |             
          Inflammation, Chronic Active     |                                                             2     2     2|             
      Site of Application-No Mass, Ulcer   |                                                             4     2     4|             
      Site of Application-No Mass, Ulcer,  |                                                                          |             
           Multiple                        |                                                                          |             
      Tail, Acanthosis                     |                                                                          |             
      Tail, Hyperkeratosis                 |                                                                          |             
      Tail, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Femur, Cyst                          |                X                                                         |             
      Maxilla, Abscess                     |                                                                          |             
      Maxilla, Fibrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|             
                                           | 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125                                    | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X     X        X     X     X                    X  X     X  X|             
      Hydrocephalus                        |             2     2        3     2     3                    3  4        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1        1                             1                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |    1        1           1                          1                     |             
      Mediastinum, Fibrosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                X         |             
      Inflammation, Chronic Active         |                   2              2                 1           3         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          3                                2                             2|             
      Respiratory Epithelium, Hyperplasia  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Lens, Cataract                       |                                  4                                       |             
      Retina, Atrophy                      |                                  4                                       |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  3  4  2  2  4  2  2  3  2  3  4  3  2  3  1  3  2  2  3  2  2  2  2|             
      Renal Tubule, Hyperplasia            |                   3                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Hemorrhagic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 7| 6| 5| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4|                                            |            |
                                           | 6| 2| 2| 2| 8| 5| 8| 0| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    125                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |     10     |
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                         X                                                |      2     |
      Hepatodiaphragmatic Nodule           |          X     X                                                         |      3     |
      Inflammation, Chronic                |                                                                          |     15  1.1|
      Mixed Cell Focus                     |                            X                                             |      2     |
      Necrosis, Coagulative                |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               |    1  3  2  2  1  1  2  3  2                                             |     52  1.8|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      8  1.6|
      Hepatocyte, Vacuolization Cytoplasmic|                   2        3                                             |      6  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +                                                         |   5        |
      Fat, Inflammation, Necrotizing       |             3  4                                                         |      4  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Acinus, Atrophy                      |       2                 1  2                                             |     17  1.4|
      Acinus, Hyperplasia, Nodular         |                                                                          |      3  2.3|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Necrotizing            |             3  4           3                                             |      6  3.3|
      Epithelium, Hyperplasia              |             3  2           2                                             |      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mesenteric Artery, Thrombosis        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy, Chronic              | 2  2     2  2  1  2     2  2                                             |     55  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 7| 6| 5| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4|                                            |            |
                                           | 6| 2| 2| 2| 8| 5| 8| 0| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    125                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Fatty                  |          1                 1                                             |     22  1.4|
      Hyperplasia                          |          1           2     1                                             |     24  1.6|
      Hypertrophy                          |                                                                          |      5  2.0|
      Karyomegaly                          |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |       1  1        1  1     1                                             |     21  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |    3     3     4  4  4  3  2                                             |     39  3.0|
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           |                      2                                                   |     18  2.1|
      Pars Distalis, Infarct               |             4                                                            |      1  4.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    2     2  2  2  2     2  2                                             |     35  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | X                                                                        |      1     |
      C-Cell, Hyperplasia                  |    2                 1                                                   |      9  1.6|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |             2        3     3                                             |     20  3.1|
      Fibrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 1  1  2  2  2  1  2  2  2  2                                             |     58  1.7|
      Duct, Dilatation                     |             3                                                            |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 7| 6| 5| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4|                                            |            |
                                           | 6| 2| 2| 2| 8| 5| 8| 0| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    125                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1  3     2  2  2  3  2  2  3                                             |     56  2.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |             2        3     3                                             |     13  3.1|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Polyarteritis                        |          X                                                               |      6     |
      Interstitial Cell, Hyperplasia       | 1     1  1        1                                                      |     25  1.0|
      Seminiferous Tubule, Atrophy         |                      4                                                   |      9  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      4  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +           +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      7  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Necrosis, Coagulative                |             4                                                            |      2  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  M  +  +  +  +                                             |  54        |
      Hyperplasia, Cystic                  |    3  1  3        2  3  2  2                                             |     42  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Proliferative          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dermis, Site of Application-No Mass, |                                                                          |            |
           Fibrosis                        |                      4                                                   |      1  4.0|
      Epidermis, Site of Application-No    |                                                                          |            |
          Mass, Erosion                    |                                                                          |      1  3.0|
      Neck, Ventral, Inflammation, Chronic |                                                                          |            |
          Active                           |    3                                                                     |      1  3.0|
      Prepuce, Inflammation, Suppurative   |                                                                          |      1  3.0|
      Site of Application-No Mass,         |                                                                          |            |
          Acanthosis                       |             2                                                            |     11  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 7| 6| 5| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4|                                            |            |
                                           | 6| 2| 2| 2| 8| 5| 8| 0| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    125                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Site of Application-No Mass,         |                                                                          |            |
          Inflammation, Chronic Active     |             2                                                            |      8  1.9|
      Site of Application-No Mass, Ulcer   |                                                                          |      4  3.0|
      Site of Application-No Mass, Ulcer,  |                                                                          |            |
           Multiple                        |                                                                          |      1  4.0|
      Tail, Acanthosis                     |                                                                          |      1  3.0|
      Tail, Hyperkeratosis                 |                                                                          |      1  4.0|
      Tail, Inflammation, Chronic Active   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      1     |
      Femur, Cyst                          |                                                                          |      1     |
      Maxilla, Abscess                     |          3                                                               |      1  3.0|
      Maxilla, Fibrosis                    |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |    X     X     X  X     X  X                                             |     21     |
      Hydrocephalus                        |          2     2  2        4                                             |     18  2.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      5  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                            1                                             |     13  1.0|
      Mediastinum, Fibrosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic Active         |                      4     2                                             |      9  2.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                2           3                                             |      8  2.4|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05109-11                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 04/18/97  
Route: DERMAL,SOLUTION                                                                                            Time: 08:55:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 7| 6| 5| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4|                                            |            |
                                           | 6| 2| 2| 2| 8| 5| 8| 0| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    125                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   2        |
      Lens, Cataract                       |                   4                                                      |      2  4.0|
      Retina, Atrophy                      |                   4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy, Chronic                 | 1  2  2  3  2  2  4  2  3  3                                             |     60  2.5|
      Renal Tubule, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Hemorrhagic            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.