Share This:
https://ntp.niehs.nih.gov/go/897

TDMS Study 05109-11 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                                      TRIETHANOLAMINE                                    DATE: 05/19/95       
EXPERIMENT: 05109 TEST: 11                                                                                     TIME: 23:42:56       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85226                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 61621D       
PATHOLOGIST: J. TOFF                                                                                           CAS: 102-71-6        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Columbus                                      TRIETHANOLAMINE                                    DATE: 05/19/95      
EXPERIMENT: 05109 TEST: 11                                                                                     TIME: 23:42:56      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-85226                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 61621D      
PATHOLOGIST: J. TOFF                                                                                           CAS: 102-71-6       

                                  TRIETHANOLAMINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 27     CENSORED DEATHS 12   TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      12    452   535   536   538   550   554   554   577   586                 |
 |      589   591   609   618   621   631   642   654   656   670                 |
 |      670   670   702   705   705   705   710                                   |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |      476   727                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 32 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 39     CENSORED DEATHS 10   TERMINAL 11        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      416   420   443   467   484   507   549   558   558   564                 |
 |      572   573   578   599   604   606   608   613   619   620                 |
 |      621   631   634   635   649   667   677   684   690   694                 |
 |      702   710   718   719   719   724   724   726   727                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 63 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 31     CENSORED DEATHS 10   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      353   365   379   431   500   522   562   574   575   579                 |
 |      584   586   616   617   623   631   631   634   642   649                 |
 |      652   702   702   710   710   710   719   722   724   724                 |
 |      724                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                                  TRIETHANOLAMINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 125     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 31     CENSORED DEATHS 10   TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      404   424   444   459   502   502   535   543   546   558                 |
 |      558   562   563   572   572   579   617   642   642   645                 |
 |      649   664   665   667   670   684   688   690   691   718                 |
 |      722                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                                  TRIETHANOLAMINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |    98.3  98.3  98.3  98.3  98.3  96.7  90.5  76.1  61.7  45.2      |
 |           |                                                                    |
 |           |                                                                    |
 |32 MG/KG   |   100.0 100.0 100.0 100.0  96.7  91.0  88.9  70.7  50.5  22.2      |
 |           |                                                                    |
 |           |                                                                    |
 |63 MG/KG   |   100.0 100.0 100.0  96.6  94.9  93.2  89.1  76.6  58.0  37.3      |
 |           |                                                                    |
 |           |                                                                    |
 |125        |   100.0 100.0 100.0 100.0  96.7  93.0  84.9  68.7  54.6  38.4      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      32 MG/KG     63 MG/KG     125      |
 |                                                                       MG/KG    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       45.2%        22.2%        37.3%        38.4%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.861      P=0.053      P=0.647      P=0.482  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       594.1        615.6        608.1        592.8    |
 |NATURAL DEATHS (C)      |       (25.8)       (14.2)       (19.5)       (15.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       618.6        609.8        619.2        613.1    |
 |(STANDARD ERROR)        |       (17.1)       (14.0)       (15.7)       (14.6)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  TRIETHANOLAMINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 25     CENSORED DEATHS 10   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      338   390   466   542   555   567   582   593   634   636                 |
 |      638   639   663   671   674   674   691   699   710   710                 |
 |      713   718   719   719   728                                               |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 63 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 10   TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      400   434   443   504   536   562   576   579   583   595                 |
 |      600   649   662   664   673   678   691   699   708   715                 |
 |      727                                                                       |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 125     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 25     CENSORED DEATHS 10   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      222   399   477   484   544   544   574   593   600   619                 |
 |      631   639   639   648   670   673   691   700   710   714                 |
 |      718   719   724   725   728                                               |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                  TRIETHANOLAMINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 250     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 32     CENSORED DEATHS 10   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      125   250   353   353   358   389   394   420   429   439                 |
 |      459   463   522   524   556   588   588   610   617   624                 |
 |      631   633   644   649   657   667   670   670   690   700                 |
 |      713   718                                                                 |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                  TRIETHANOLAMINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0  98.3  96.7  94.7  92.6  84.6  74.5  50.3      |
 |           |                                                                    |
 |           |                                                                    |
 |63 MG/KG   |   100.0 100.0 100.0 100.0  98.3  95.0  91.0  78.8  72.8  58.6      |
 |           |                                                                    |
 |           |                                                                    |
 |125        |   100.0 100.0  98.3  98.3  96.7  92.6  88.6  82.6  72.5  50.3      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |250        |   100.0  98.3  96.7  91.7  86.7  79.2  75.0  68.7  52.1  37.5      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      63 MG/KG     125          250      |
 |                                                          MG/KG        MG/KG    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       50.3%        58.6%        50.3%        37.5%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.018      P=0.659N     P=1.000      P=0.057  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       626.8        603.7        615.4        534.5    |
 |NATURAL DEATHS (C)      |       (20.8)       (21.2)       (24.1)       (26.3)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       641.1        639.8        636.3        579.9    |
 |(STANDARD ERROR)        |       (15.0)       (14.9)       (15.9)       (19.2)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                          TRIETHANOLAMINE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        32 MG/KG         = 2
                                                        63 MG/KG         = 3
                                                        125     MG/KG    = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 1                                                     3       4 2
      |   1                                                     3 3  3  4 24  2 1            1
      |                                                              3      3 2  42
      |                                                                     3    42  2 3
   90 +                                                                              2 32  3 1 1 3
      |                                                                                      441133
      |                                                                                         1 31
      |                                                                                       4 22 11
P  80 +                                                                                         42231 1
E     |                                                                                           223    3
R     |                                                                                          442  12131
C     |                                                                                                22
E  70 +                                                                                           44      1 1
N     |                                                                                            4    224 11
T     |                                                                                                  22 31 1
      |                                                                                                      331  1
S  60 +                                                                                                       33
U     |                                                                                                   2 2 43 4     3
R     |                                                                                                          41    13
V     |                                                                                                     2 2
I  50 +                                                                                                       2   2 4
V     |                                                                                                           2224 113
A     |                                                                                                             22  133 1
L     |                                                                                                              22  4
   40 +                                                                                                               22 44
      |                                                                                                                2223 3
      |
      |
   30 +                                                                                                                  22
      |
      |
      |                                                                                                                   2 2
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 39 obs hidden.

                                                          TRIETHANOLAMINE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        63 MG/KG         = 2
                                                        125     MG/KG    = 3
                                                        250     MG/KG    = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

         |
         |
  100.00 +1                   4              3                  1         2
         |                    4              3    4             1       132   2
         |                                        4               4     13    2 2   1 3  2
         |                                                        44                1 33 2     21
   91.67 +                                                         4    4              3       21 11
         |                                                              44                      3  1321
         |                                                               4  4 4                     3 1 1
         |                                                                    44                     22 13    1
P  83.33 +                                                                     4   4                  2 23  3
E        |                                                                         44                   22  3 11
R        |                                                                          4        4           2    332
C        |                                                                                                     12  1
E  75.00 +                                                                                   4    4            33  11
N        |                                                                                        4   4         3  211
T        |                                                                                                          33
         |                                                                                            4    4         1 1
S  66.67 +                                                                                                 44          11
U        |                                                                                                  44          1 1
R        |                                                                                                   44           22
V        |                                                                                                                322
I  58.33 +                                                                                                    44          112 2
V        |                                                                                                     44          33
A        |                                                                                                      44
L        |                                                                                                       4  4      11
   50.00 +                                                                                                                  1 1
         |
         |                                                                                                          4  4
         |                                                                                                             44
   41.67 +                                                                                                              4 4
         |                                                                                                                44
         |                                                                                                                 4  4
         |
   33.33 +
         |
         -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
          0         10         20         30         40         50         60         70         80         90         100       110

                                                                     WEEK

NOTE: 30 obs hidden.