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TDMS Study 05109-14 Pathology Tables

NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02
Route: SKIN APPLICATION                                                                                           Time: 08:29:26

                                                         FINAL #1/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  102-71-6

       Lock Date:  05/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            6            4            7                                     
    Moribund Sacrifice                                 8           10            5           10                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           34           41           32                                     
    Natural Death                                      1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Epithelium, Necrosis                             1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Diverticulum                                                                            1 (2%)                                
      Ulcer                                                         1 (2%)                                                          
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
      Peyer's Patch, Inflammation, Suppurative                                   1 (2%)                                             
      Serosa, Inflammation, Granulomatous                                                     1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                         1 (2%)                                             
      Basophilic Focus                                 4 (8%)                    3 (6%)       3 (6%)                                
      Clear Cell Focus                                 4 (8%)       3 (6%)       3 (6%)       5 (10%)                               
      Eosinophilic Focus                              16 (32%)     22 (44%)     28 (56%)     32 (64%)                               
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 4 (8%)       3 (6%)       3 (6%)       4 (8%)                                
      Hepatodiaphragmatic Nodule                                    2 (4%)                                                          
      Infiltration Cellular, Lymphoid                 26 (52%)     30 (60%)     36 (72%)     20 (40%)                               
      Inflammation, Chronic                           14 (28%)     27 (54%)     22 (44%)     15 (30%)                               
      Mixed Cell Focus                                 5 (10%)      8 (16%)     14 (28%)     11 (22%)                               
      Necrosis, Focal                                               5 (10%)      1 (2%)       3 (6%)                                
      Vacuolization Cytoplasmic, Focal                 8 (16%)      1 (2%)       6 (12%)      6 (12%)                               
      Centrilobular, Cytomegaly, Diffuse                                         1 (2%)                                             
      Centrilobular, Necrosis                          1 (2%)                    1 (2%)                                             
   Mesentery                                          (11)         (6)          (4)          (9)                                    
      Inflammation, Chronic                            1 (9%)                                                                       
      Fat, Necrosis                                   10 (91%)      6 (100%)     3 (75%)      9 (100%)                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Lymphatic, Angiectasis                           1 (9%)                                                                       
   Oral Mucosa                                        (26)         (26)         (31)         (31)                                   
      Inflammation, Chronic                           26 (100%)    26 (100%)    31 (100%)    31 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  1 (2%)       3 (6%)       1 (2%)                                             
      Acinus, Hyperplasia                                           1 (2%)                                                          
      Duct, Cyst                                       1 (2%)       2 (4%)       1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
      Ulcer                                                         1 (2%)       2 (4%)                                             
      Epithelium, Cyst                                                                        1 (2%)                                
      Epithelium, Hyperplasia, Focal                                1 (2%)                    1 (2%)                                
      Epithelium, Mineralization                                                 1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Ulcer                                                         1 (2%)                    1 (2%)                                
      Epithelium, Cyst                                 1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   1 (2%)                    1 (2%)       1 (2%)                                
      Serosa, Inflammation, Chronic                                                           1 (2%)                                
   Tooth                                                                        (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic                                               2 (4%)                                             
      Aorta, Mineralization                            1 (2%)       2 (4%)                                                          
   Heart                                              (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic                    3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Atrium, Thrombosis                               2 (4%)                                                                       
      Myocardium, Degeneration                         4 (8%)                    1 (2%)                                             
      Myocardium, Inflammation, Acute                  1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                                          1 (2%)                                             
      Myocardium, Mineralization                       1 (2%)       2 (4%)                                                          
      Myocardium, Necrosis                                                       1 (2%)                                             
      Pericardium, Inflammation, Chronic                                         1 (2%)                                             
      Valve, Inflammation                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
      Hypertrophy, Focal                                            2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Subcapsular, Hyperplasia                        49 (98%)     49 (98%)     50 (100%)    50 (100%)                              
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     25 (50%)     18 (36%)     20 (40%)     18 (36%)                               
   Parathyroid Gland                                  (39)         (41)         (45)         (46)                                   
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Pars Distalis, Hyperplasia                      11 (22%)      3 (6%)       9 (18%)     12 (24%)                               
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                                             
      C-Cell, Hyperplasia                                                                     2 (4%)                                
      Follicle, Cyst                                   1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Follicular Cell, Necrosis                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (49)         (49)                                   
      Cyst                                             2 (4%)                                 1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)                    2 (4%)                                             
      Cyst                                            27 (54%)     22 (44%)     21 (42%)     25 (50%)                               
      Mineralization                                                                          1 (2%)                                
      Thrombosis                                                    1 (2%)       3 (6%)       1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                49 (98%)     48 (96%)     47 (94%)     47 (94%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
      Myeloid Cell, Hyperplasia                        1 (2%)                                                                       
   Lymph Node                                         (6)          (7)          (4)          (6)                                    
      Deep Cervical, Hyperplasia, Lymphoid                          1 (14%)                                                         
      Iliac, Hyperplasia, Lymphoid                                  1 (14%)      1 (25%)                                            
      Lumbar, Hyperplasia, Lymphoid                    1 (17%)                   1 (25%)                                            
      Lumbar, Inflammation, Acute                      1 (17%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 (17%)      1 (14%)                   2 (33%)                               
      Renal, Hyperplasia, Lymphoid                                                            1 (17%)                               
   Lymph Node, Mandibular                             (49)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
   Lymph Node, Mesenteric                             (50)         (49)         (48)         (48)                                   
      Hyperplasia, Histiocytic                                                   1 (2%)                                             
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Atrophy                                          1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                32 (64%)     24 (48%)     30 (61%)     33 (66%)                               
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Thymus                                             (49)         (49)         (49)         (49)                                   
      Atrophy                                         13 (27%)     17 (35%)     19 (39%)     16 (33%)                               
      Hyperplasia, Focal                               1 (2%)                                                                       
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Duct, Dilatation                                 1 (2%)                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Epidermis, Hyperkeratosis                        1 (2%)                                                                       
      Epidermis, Hyperplasia                           1 (2%)                                                                       
      Epidermis, Inflammation, Suppurative             1 (2%)                                                                       
      Epidermis, Ulcer                                 1 (2%)                                                                       
      Site of Application - Epidermis,                                                                                              
          Hyperkeratosis                               3 (6%)                                                                       
      Site of Application - Epidermis, Hyperplasia    14 (28%)     50 (100%)    46 (92%)     50 (100%)                              
      Site of Application - Epidermis,                                                                                              
          Inflammation, Suppurative                    1 (2%)       2 (4%)      20 (40%)     32 (64%)                               
      Site of Application - Epidermis, Ulcer           1 (2%)       1 (2%)       6 (12%)     17 (34%)                               
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Fibrosis                                                           1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                                                       
      Subcutaneous Tissue, Necrosis                    1 (2%)                                                                       
      Subcutaneous Tissue, Site of Application -                                                                                    
          Dermis, Inflammation, Chronic                4 (8%)      27 (54%)     31 (62%)     44 (88%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                         7 (14%)      6 (12%)     13 (26%)     10 (20%)                               
      Fracture                                                                                1 (2%)                                
      Hyperostosis                                                  1 (2%)                                                          
      Cranium, Callus                                                            1 (2%)                                             
      Femur, Hyperostosis                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Hydrocephalus                                                              1 (2%)                                             
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Artery, Meninges, Inflammation, Chronic                       1 (2%)                                                          
      Hypothalamus, Compression                                                  3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            2 (4%)                    3 (6%)       1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Mineralization                                                2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal                                    1 (2%)       1 (2%)                                
      Bronchus, Hyperplasia, Focal                     1 (2%)                                                                       
      Bronchus, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic                                         1 (2%)                                             
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Sinus, Inflammation, Suppurative                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                        0 MG/KG      100          300          1000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (50)         (50)         (50)                                   
      Degeneration                                     1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
   Harderian Gland                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      4 (8%)       3 (6%)       4 (8%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)       5 (10%)      3 (6%)       3 (6%)                                
      Metaplasia, Osseous                                                        1 (2%)       3 (6%)                                
      Nephropathy                                     24 (48%)     18 (36%)     23 (46%)     20 (40%)                               
      Glomerulus, Amyloid Deposition                                2 (4%)                                                          
      Glomerulus, Cyst                                                                        1 (2%)                                
      Papilla, Necrosis                                1 (2%)       1 (2%)                    1 (2%)                                
      Papilla, Renal Tubule, Atrophy                                                          1 (2%)                                
      Pelvis, Inflammation, Granulomatous                                        1 (2%)                                             
      Renal Tubule, Cyst                                                         1 (2%)                                             
      Renal Tubule, Cytoplasmic Alteration                          1 (2%)                                                          
      Renal Tubule, Mineralization                                                            1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (49)                                   
      Cyst                                                                                    1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            2            6            8                                     
    Natural Death                                      8            5           10            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           43           34           40                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (49)         (50)         (47)                                   
      Necrosis                                         1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Goblet Cell, Hyperplasia                                                   1 (2%)                                             
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Diverticulum                                     1 (2%)                                                                       
      Epithelium, Hyperplasia                                       1 (2%)                                                          
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                 1 (2%)                                
      Serosa, Inflammation, Granulomatous                           1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Muscularis, Infiltration Cellular,                                                                                            
          Mononuclear Cell                                                       1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 2 (4%)       6 (12%)      3 (6%)       2 (4%)                                
      Clear Cell Focus                                19 (38%)     23 (46%)     14 (28%)     11 (22%)                               
      Eosinophilic Focus                               9 (18%)     20 (40%)     31 (62%)     30 (60%)                               
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                 3 (6%)       4 (8%)       1 (2%)       2 (4%)                                
      Hepatodiaphragmatic Nodule                       1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Lymphoid                  3 (6%)       2 (4%)       2 (4%)       3 (6%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            9 (18%)     14 (28%)     10 (20%)     11 (22%)                               
      Mixed Cell Focus                                13 (26%)     11 (22%)     15 (30%)      8 (16%)                               
      Necrosis, Focal                                  4 (8%)       3 (6%)       7 (14%)      6 (12%)                               
      Vacuolization Cytoplasmic, Focal                 2 (4%)       1 (2%)       3 (6%)       5 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis                                       1 (2%)       1 (2%)                                             
   Mesentery                                          (3)          (3)          (5)          (7)                                    
      Inflammation, Granulomatous                                                1 (20%)                                            
      Artery, Inflammation, Chronic                                                           1 (14%)                               
      Fat, Necrosis                                    3 (100%)     3 (100%)     4 (80%)      5 (71%)                               
   Oral Mucosa                                        (31)         (26)         (35)         (30)                                   
      Inflammation, Chronic                           31 (100%)    26 (100%)    35 (100%)    30 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                               1 (2%)                                                          
      Duct, Cyst                                                                              1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                                                      1 (2%)       1 (2%)                                
      Epithelium, Cyst                                                                        1 (2%)                                
      Epithelium, Hyperplasia, Focal                   3 (6%)                    3 (6%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Ulcer                                                                      2 (4%)                                             
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
      Glands, Ectasia                                               1 (2%)                                                          
   Tooth                                              (19)         (18)         (14)         (13)                                   
      Malformation                                    19 (100%)    18 (100%)    14 (100%)    13 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic                                                            1 (2%)                                
      Aorta, Mineralization                                         1 (2%)                                                          
      Pulmonary Vein, Thrombosis                                                              1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mononuclear Cell          3 (6%)       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                                                   2 (4%)                                
      Artery, Inflammation, Chronic                                 1 (2%)                    3 (6%)                                
      Atrium, Thrombosis                               1 (2%)       1 (2%)                                                          
      Coronary Artery, Inflammation, Chronic                                                  1 (2%)                                
      Myocardium, Degeneration                                      1 (2%)                                                          
      Myocardium, Mineralization                       1 (2%)                    1 (2%)       2 (4%)                                
      Valve, Inflammation, Chronic                                  1 (2%)                                                          
      Ventricle, Thrombosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                               8 (16%)      4 (8%)       3 (6%)       1 (2%)                                
      Hypertrophy, Focal                              16 (32%)     21 (42%)     10 (20%)     10 (20%)                               
      Necrosis                                                                   1 (2%)                                             
      Subcapsular, Hyperplasia                        39 (78%)     45 (90%)     40 (80%)     40 (80%)                               
      Zona Glomerulosa, Hyperplasia                                 2 (4%)       3 (6%)       1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                                                                      2 (4%)                                
      Necrosis                                                                   1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     45 (90%)     43 (86%)     43 (86%)     32 (64%)                               
   Pituitary Gland                                    (50)         (49)         (49)         (50)                                   
      Pars Distalis, Hyperplasia                       1 (2%)       2 (4%)                    1 (2%)                                
      Pars Intermedia, Hyperplasia                     1 (2%)                                 3 (6%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Follicle, Cyst                                   1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (1)          (1)                                    
      Cyst                                                                       1 (100%)                                           
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Cyst                                            10 (20%)     14 (28%)     11 (22%)     15 (30%)                               
      Inflammation, Chronic                            1 (2%)                                 2 (4%)                                
      Inflammation, Suppurative                                     1 (2%)                    3 (6%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Hyperplasia                                      1 (2%)       2 (4%)       2 (4%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                                             1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Germinal Epithelium, Atrophy                     4 (8%)       2 (4%)       1 (2%)       2 (4%)                                
      Germinal Epithelium, Mineralization                           2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mesenteric                             (50)         (48)         (48)         (50)                                   
      Congestion                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Atrophy                                          4 (8%)       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                14 (29%)     20 (40%)     17 (34%)     19 (38%)                               
      Lymphoid Follicle, Hematopoietic Cell                                                                                         
          Proliferation                                1 (2%)                    1 (2%)                                             
      Red Pulp, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         1 (2%)                                                                       
   Thymus                                             (48)         (47)         (48)         (48)                                   
      Atrophy                                         38 (79%)     37 (79%)     37 (77%)     38 (79%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Dermis, Edema                                                              1 (2%)                                             
      Epidermis, Hyperkeratosis                        1 (2%)                                                                       
      Epidermis, Ulcer                                 1 (2%)                                                                       
      Site of Application - Epidermis,                                                                                              
          Hyperkeratosis                               3 (6%)                                                                       
      Site of Application - Epidermis, Hyperplasia     5 (10%)     44 (88%)     45 (90%)     49 (98%)                               
      Site of Application - Epidermis,                                                                                              
          Inflammation, Suppurative                    1 (2%)      11 (22%)     33 (66%)     42 (84%)                               
      Site of Application - Epidermis, Ulcer                        3 (6%)      20 (40%)     47 (94%)                               
      Subcutaneous Tissue, Site of Application -                                                                                    
          Dermis, Inflammation, Chronic                1 (2%)      15 (30%)     40 (80%)     49 (98%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                                                             1 (2%)                                
   Spinal Cord                                        (1)                                                                           
      Necrosis                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                                            1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Granulomatous                      2 (4%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Bronchus, Hyperplasia, Focal                                  1 (2%)                                                          
      Perivascular, Infiltration Cellular, Lymphoid                                           1 (2%)                                
      Vein, Thrombosis                                                                        1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        2 (4%)                    1 (2%)                                             
      Polyp, Inflammatory                                           1 (2%)                                                          
      Respiratory Epithelium, Mineralization                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Degeneration                                     1 (2%)                                                                       
      Cornea, Inflammation, Acute                                                             1 (2%)                                
      Retrobulbar, Inflammation, Suppurative           1 (2%)                                                                       
   Harderian Gland                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      3 (6%)       5 (10%)      6 (12%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          2 (4%)       3 (6%)       2 (4%)       4 (8%)                                
      Inflammation, Acute                              2 (4%)                                                                       
      Metaplasia, Osseous                              1 (2%)       4 (8%)       2 (4%)       2 (4%)                                
      Nephropathy                                     39 (78%)     42 (84%)     37 (74%)     40 (80%)                               
      Artery, Thrombosis                                            1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                          TRIETHANOLAMINE                                      Date: 06/06/02    
Route: SKIN APPLICATION                                                                                           Time: 08:29:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                          0 MG/KG      200          630          2000                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Capsule, Inflammation, Chronic                                             1 (2%)                                             
      Glomerulus, Cyst                                              2 (4%)                    2 (4%)                                
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Cyst                               4 (8%)       2 (4%)                    4 (8%)                                
      Renal Tubule, Hyperplasia                                     1 (2%)       1 (2%)       2 (4%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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