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TDMS Study 05109-14 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                      TRIETHANOLAMINE                                    DATE: 06/06/02       
EXPERIMENT: 05109 TEST: 14                                                                                     TIME: 08:39:59       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85427                              ROUTE: SKIN APPLICATION                                        NTP C#: 61621E       
PATHOLOGIST: MISSING                                                                                           CAS: 102-71-6        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                      TRIETHANOLAMINE                                    DATE: 06/06/02       
EXPERIMENT: 05109 TEST: 14                                                                                     TIME: 08:39:59       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85427                              ROUTE: SKIN APPLICATION                                        NTP C#: 61621E       
PATHOLOGIST: MISSING                                                                                           CAS: 102-71-6        
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Salivary Glands                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                      TRIETHANOLAMINE                                    DATE: 06/06/02       
EXPERIMENT: 05109 TEST: 14                                                                                     TIME: 08:39:59       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85427                              ROUTE: SKIN APPLICATION                                        NTP C#: 61621E       
PATHOLOGIST: MISSING                                                                                           CAS: 102-71-6        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                 TRIETHANOLAMINE                                                                                  
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hemangiosarcoma                                                                              
All Organs                             Hemangiosarcoma                                                                              
                                       Benign Tumors                                                                                
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Thyroid Gland: Follicular Cell         Adenoma                                                                                      
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                  TRIETHANOLAMINE               
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    6/50 (12%)   5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/47.21      3/46.90      6/43.61      5/46.42     |0/44.21      0/43.59      0/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     6.4%         6.4%         13.8%        10.8%       |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     3/37 (8%)    3/43 (7%)    4/34 (12%)   4/40 (10%)  |0/35 (0%)    0/34 (0%)    0/41 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      676          618         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.305      P=0.592N     P=0.199      P=0.392     |P=0.201      (e)          (e)          P=0.482      | 
|POLY 3             |     P=0.285      P=0.659      P=0.204      P=0.347     |P=0.222      (e)          (e)          P=0.500      | 
|POLY 1.5           |     P=0.289      P=0.658      P=0.218      P=0.350     |P=0.221      (e)          (e)          P=0.499      | 
|POLY 6             |     P=0.281      P=0.660N     P=0.193      P=0.347     |P=0.223      (e)          (e)          P=0.502      | 
|LOGISTIC REGRESSION|     P=0.281      P=0.592N     P=0.186      P=0.346     |(e)          (e)          (e)          P=0.482      | 
|COCH-ARM / FISHERS |     P=0.294      P=0.661N     P=0.243      P=0.357     |P=0.221      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   2/50 (4%)    2/50 (4%)    6/50 (12%)  |5/50 (10%)   5/50 (10%)   3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/47.86      2/46.90      2/43.35      6/46.04     |5/44.45      5/44.29      3/44.71      3/44.92      | 
|POLY-3 PERCENT (g) |     14.6%        4.3%         4.6%         13.0%       |11.3%        11.3%        6.7%         6.7%         | 
|TERMINAL (d)       |     6/37 (16%)   2/43 (5%)    2/34 (6%)    6/40 (15%)  |4/35 (11%)   3/34 (9%)    3/41 (7%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     511          726 (T)      726 (T)      726 (T)     |666          594          729 (T)      527          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.394      P=0.055N     P=0.104N     P=0.446N    |P=0.319N     P=0.625      P=0.276N     P=0.390N     | 
|POLY 3             |     P=0.369      P=0.084N     P=0.105N     P=0.530N    |P=0.279N     P=0.628      P=0.353N     P=0.350N     | 
|POLY 1.5           |     P=0.374      P=0.083N     P=0.095N     P=0.519N    |P=0.283N     P=0.624      P=0.361N     P=0.356N     | 
|POLY 6             |     P=0.361      P=0.082N     P=0.115N     P=0.539N    |P=0.278N     P=0.626N     P=0.337N     P=0.344N     | 
|LOGISTIC REGRESSION|     P=0.367      P=0.078N     P=0.086N     P=0.509N    |P=0.285N     P=0.623      P=0.328N     P=0.358N     | 
|COCH-ARM / FISHERS |     P=0.379      P=0.080N     P=0.080N     P=0.500N    |P=0.285N     P=0.630N     P=0.357N     P=0.357N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.90      0/43.35      1/46.39     |2/45.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         2.2%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          628         |532          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.464      P=0.530      (e)          P=0.491     |P=0.265N     P=0.247N     P=0.247N     P=0.245N     | 
|POLY 3             |     P=0.460      P=0.499      (e)          P=0.497     |P=0.255N     P=0.245N     P=0.240N     P=0.242N     | 
|POLY 1.5           |     P=0.461      P=0.498      (e)          P=0.498     |P=0.256N     P=0.244N     P=0.241N     P=0.241N     | 
|POLY 6             |     P=0.460      P=0.501      (e)          P=0.496     |P=0.255N     P=0.247N     P=0.235N     P=0.243N     | 
|LOGISTIC REGRESSION|     P=0.468      P=0.530      (e)          P=0.572     |P=0.244N     P=0.178N     P=0.181N     P=0.186N     | 
|COCH-ARM / FISHERS |     P=0.464      P=0.500      (e)          P=0.500     |P=0.262N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    2/50 (4%)    7/50 (14%)  |7/50 (14%)   5/50 (10%)   3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/47.86      3/46.90      2/43.35      7/46.39     |7/45.45      5/44.29      3/44.71      3/44.92      | 
|POLY-3 PERCENT (g) |     14.6%        6.4%         4.6%         15.1%       |15.4%        11.3%        6.7%         6.7%         | 
|TERMINAL (d)       |     6/37 (16%)   3/43 (7%)    2/34 (6%)    6/40 (15%)  |4/35 (11%)   3/34 (9%)    3/41 (7%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     511          726 (T)      726 (T)      628         |532          594          729 (T)      527          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311      P=0.112N     P=0.104N     P=0.564N    |P=0.188N     P=0.390N     P=0.121N     P=0.187N     | 
|POLY 3             |     P=0.289      P=0.166N     P=0.105N     P=0.589     |P=0.161N     P=0.397N     P=0.164N     P=0.162N     | 
|POLY 1.5           |     P=0.292      P=0.165N     P=0.095N     P=0.597     |P=0.163N     P=0.395N     P=0.166N     P=0.163N     | 
|POLY 6             |     P=0.285      P=0.163N     P=0.115N     P=0.584     |P=0.162N     P=0.397N     P=0.157N     P=0.162N     | 
|LOGISTIC REGRESSION|     P=0.289      P=0.156N     P=0.086N     P=0.609N    |P=0.163N     P=0.374N     P=0.159N     P=0.151N     | 
|COCH-ARM / FISHERS |     P=0.296      P=0.159N     P=0.080N     P=0.613N    |P=0.163N     P=0.380N     P=0.159N     P=0.159N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.21      1/46.90      0/43.35      1/46.04     |0/44.21      1/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     6.4%         2.1%         0.0%         2.2%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    1/43 (2%)    0/34 (0%)    1/40 (3%)   |0/35 (0%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          726 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347N     P=0.253N     P=0.136N     P=0.278N    |P=0.619N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.352N     P=0.308N     P=0.135N     P=0.314N    |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 1.5           |     P=0.351N     P=0.309N     P=0.129N     P=0.311N    |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.354N     P=0.304N     P=0.141N     P=0.317N    |P=0.604N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.347N     P=0.253N     (e)          P=0.278N    |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.352N     P=0.309N     P=0.121N     P=0.309N    |P=0.601N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.21      1/46.90      0/43.35      1/46.04     |0/44.21      1/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     6.4%         2.1%         0.0%         2.2%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    1/43 (2%)    0/34 (0%)    1/40 (3%)   |0/35 (0%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          726 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347N     P=0.253N     P=0.136N     P=0.278N    |P=0.619N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.352N     P=0.308N     P=0.135N     P=0.314N    |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 1.5           |     P=0.351N     P=0.309N     P=0.129N     P=0.311N    |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.354N     P=0.304N     P=0.141N     P=0.317N    |P=0.604N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.347N     P=0.253N     (e)          P=0.278N    |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.352N     P=0.309N     P=0.121N     P=0.309N    |P=0.601N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.21      1/46.90      0/43.35      2/46.88     |0/44.21      1/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     6.4%         2.1%         0.0%         4.3%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    1/43 (2%)    0/34 (0%)    1/40 (3%)   |0/35 (0%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          399         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.624N     P=0.253N     P=0.136N     P=0.472N    |P=0.619N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.629N     P=0.308N     P=0.135N     P=0.503N    |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 1.5           |     P=0.630N     P=0.309N     P=0.129N     P=0.502N    |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.631N     P=0.304N     P=0.141N     P=0.504N    |P=0.604N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.625N     P=0.253N     (e)          P=0.419N    |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.633N     P=0.309N     P=0.121N     P=0.500N    |P=0.601N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      1/43.35      2/46.21     |0/44.21      0/43.59      0/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.3%         4.3%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    1/34 (3%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          726 (T)      683         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.470N     P=0.743      P=0.513     |P=0.201      (e)          (e)          P=0.482      | 
|POLY 3             |     P=0.232      P=0.501N     P=0.741      P=0.493     |P=0.222      (e)          (e)          P=0.500      | 
|POLY 1.5           |     P=0.234      P=0.502N     P=0.748      P=0.495     |P=0.221      (e)          (e)          P=0.499      | 
|POLY 6             |     P=0.229      P=0.499N     P=0.734      P=0.491     |P=0.223      (e)          (e)          P=0.502      | 
|LOGISTIC REGRESSION|     P=0.231      (e)          P=0.743      P=0.494     |(e)          (e)          (e)          P=0.482      | 
|COCH-ARM / FISHERS |     P=0.235      P=0.500N     P=0.753N     P=0.500     |P=0.221      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.90      0/43.35      2/46.04     |1/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         4.3%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    2/40 (5%)   |1/35 (3%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          726 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157      P=0.530      (e)          P=0.256     |P=0.515N     P=0.506N     P=0.468N     P=0.518N     | 
|POLY 3             |     P=0.146      P=0.499      (e)          P=0.232     |P=0.499N     P=0.503N     P=0.498N     P=0.500N     | 
|POLY 1.5           |     P=0.148      P=0.498      (e)          P=0.234     |P=0.498N     P=0.503N     P=0.501N     P=0.501N     | 
|POLY 6             |     P=0.145      P=0.501      (e)          P=0.230     |P=0.501N     P=0.502N     P=0.491N     P=0.498N     | 
|LOGISTIC REGRESSION|     (e)          P=0.530      (e)          P=0.256     |P=0.515N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.150      P=0.500      (e)          P=0.247     |P=0.500N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    6/50 (12%)   1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      6/44.45      1/46.04     |0/44.21      1/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         13.5%        2.2%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    3/34 (9%)    1/40 (3%)   |0/35 (0%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          517          726 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.603      P=0.470N     P=0.047 *    P=0.744N    |P=0.619N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.587      P=0.501N     P=0.047 *    P=0.755     |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 1.5           |     P=0.595      P=0.502N     P=0.050      P=0.757     |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.578      P=0.499N     P=0.044 *    P=0.754     |P=0.604N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.611      (e)          P=0.071      P=0.744N    |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.603      P=0.500N     P=0.056      P=0.753N    |P=0.601N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.21      1/46.90      2/43.35      3/46.42     |0/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         4.6%         6.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    1/43 (2%)    2/34 (6%)    2/40 (5%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      726 (T)      618         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.193      P=0.728N     P=0.470      P=0.324     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.181      P=0.759      P=0.470      P=0.299     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.183      P=0.759      P=0.481      P=0.301     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.179      P=0.760N     P=0.460      P=0.299     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.181      P=0.728N     P=0.470      P=0.312     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.184      P=0.753N     P=0.500      P=0.309     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  18/50 (36%)  23/50 (46%)  20/50 (40%) |9/50 (18%)   18/50 (36%)  20/50 (40%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     19/47.48     18/46.90     23/43.94     20/46.78    |9/45.13      18/43.96     20/45.98     33/45.59     | 
|POLY-3 PERCENT (g) |     40.0%        38.4%        52.4%        42.8%       |19.9%        41.0%        43.5%        72.4%        | 
|TERMINAL (d)       |     17/37 (46%)  18/43 (42%)  20/34 (59%)  18/40 (45%) |6/35 (17%)   16/34 (47%)  18/41 (44%)  25/32 (78%)  | 
|FIRST INCIDENCE    |     688          726 (T)      659          618         |617          665          444          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.470      P=0.285N     P=0.155      P=0.561N    |P<0.001 **   P=0.033 *    P=0.041 *    P<0.001 **   | 
|POLY 3             |     P=0.425      P=0.519N     P=0.162      P=0.476     |P<0.001 **   P=0.024 *    P=0.012 *    P<0.001 **   | 
|POLY 1.5           |     P=0.431      P=0.517N     P=0.199      P=0.483     |P<0.001 **   P=0.026 *    P=0.011 *    P<0.001 **   | 
|POLY 6             |     P=0.419      P=0.511N     P=0.133      P=0.474     |P<0.001 **   P=0.022 *    P=0.015 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.378      P=0.446N     P=0.111      P=0.446     |P<0.001 **   P=0.031 *    P=0.013 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.441      P=0.500N     P=0.272      P=0.500     |P<0.001 **   P=0.035 *    P=0.013 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  14/50 (28%)  14/50 (28%)  11/50 (22%) |6/50 (12%)   8/50 (16%)   4/50 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     17/49.44     14/48.17     14/47.23     11/46.72    |6/45.00      8/44.74      4/45.19      5/44.40      | 
|POLY-3 PERCENT (g) |     34.4%        29.1%        29.6%        23.6%       |13.3%        17.9%        8.9%         11.3%        | 
|TERMINAL (d)       |     8/37 (22%)   11/43 (26%)  5/34 (15%)   9/40 (23%)  |3/35 (9%)    4/34 (12%)   3/41 (7%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     511          554          439          572         |595          601          586          701          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.167N     P=0.254N     P=0.469N     P=0.136N    |P=0.386N     P=0.377      P=0.315N     P=0.537N     | 
|POLY 3             |     P=0.177N     P=0.365N     P=0.390N     P=0.172N    |P=0.354N     P=0.382      P=0.367N     P=0.509N     | 
|POLY 1.5           |     P=0.162N     P=0.357N     P=0.367N     P=0.156N    |P=0.352N     P=0.378      P=0.375N     P=0.509N     | 
|POLY 6             |     P=0.200N     P=0.368N     P=0.418N     P=0.193N    |P=0.359N     P=0.390      P=0.350N     P=0.511N     | 
|LOGISTIC REGRESSION|     P=0.121N     P=0.303N     P=0.118N     P=0.110N    |P=0.345N     P=0.384      P=0.371N     P=0.501N     | 
|COCH-ARM / FISHERS |     P=0.142N     P=0.333N     P=0.333N     P=0.133N    |P=0.346N     P=0.387      P=0.370N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  15/50 (30%)  15/50 (30%)  13/50 (26%) |6/50 (12%)   8/50 (16%)   4/50 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     18/49.44     15/48.17     15/47.23     13/47.10    |6/45.00      8/44.74      4/45.19      5/44.40      | 
|POLY-3 PERCENT (g) |     36.4%        31.1%        31.8%        27.6%       |13.3%        17.9%        8.9%         11.3%        | 
|TERMINAL (d)       |     9/37 (24%)   12/43 (28%)  6/34 (18%)   10/40 (25%) |3/35 (9%)    4/34 (12%)   3/41 (7%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     511          554          439          572         |595          601          586          701          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238N     P=0.249N     P=0.476N     P=0.192N    |P=0.386N     P=0.377      P=0.315N     P=0.537N     | 
|POLY 3             |     P=0.253N     P=0.369N     P=0.395N     P=0.240N    |P=0.354N     P=0.382      P=0.367N     P=0.509N     | 
|POLY 1.5           |     P=0.237N     P=0.360N     P=0.371N     P=0.222N    |P=0.352N     P=0.378      P=0.375N     P=0.509N     | 
|POLY 6             |     P=0.276N     P=0.373N     P=0.425N     P=0.261N    |P=0.359N     P=0.390      P=0.350N     P=0.511N     | 
|LOGISTIC REGRESSION|     P=0.190N     P=0.308N     P=0.133N     P=0.161N    |P=0.345N     P=0.384      P=0.371N     P=0.501N     | 
|COCH-ARM / FISHERS |     P=0.214N     P=0.335N     P=0.335N     P=0.194N    |P=0.346N     P=0.387      P=0.370N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  27/50 (54%)  33/50 (66%)  25/50 (50%) |12/50 (24%)  23/50 (46%)  24/50 (48%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     33/49.59     27/48.17     33/47.69     25/47.46    |12/45.63     23/45.10     24/46.46     34/45.59     | 
|POLY-3 PERCENT (g) |     66.6%        56.1%        69.2%        52.7%       |26.3%        51.0%        51.7%        74.6%        | 
|TERMINAL (d)       |     23/37 (62%)  24/43 (56%)  22/34 (65%)  21/40 (53%) |7/35 (20%)   17/34 (50%)  21/41 (51%)  26/32 (81%)  | 
|FIRST INCIDENCE    |     511          554          439          572         |595          601          444          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.138N     P=0.067N     P=0.365      P=0.072N    |P<0.001 **   P=0.023 *    P=0.042 *    P<0.001 **   | 
|POLY 3             |     P=0.148N     P=0.195N     P=0.475      P=0.116N    |P<0.001 **   P=0.011 *    P=0.009 **   P<0.001 **   | 
|POLY 1.5           |     P=0.130N     P=0.183N     P=0.518      P=0.099N    |P<0.001 **   P=0.012 *    P=0.008 **   P<0.001 **   | 
|POLY 6             |     P=0.173N     P=0.203N     P=0.425      P=0.136N    |P<0.001 **   P=0.012 *    P=0.012 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.114N     P=0.155N     P=0.544N     P=0.081N    |P<0.001 **   P=0.015 *    P=0.010 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.112N     P=0.154N     P=0.583N     P=0.078N    |P<0.001 **   P=0.018 *    P=0.011 *    P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  27/50 (54%)  34/50 (68%)  26/50 (52%) |12/50 (24%)  23/50 (46%)  24/50 (48%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     33/49.59     27/48.17     34/47.69     26/47.46    |12/45.63     23/45.10     24/46.46     34/45.59     | 
|POLY-3 PERCENT (g) |     66.6%        56.1%        71.3%        54.8%       |26.3%        51.0%        51.7%        74.6%        | 
|TERMINAL (d)       |     23/37 (62%)  24/43 (56%)  23/34 (68%)  22/40 (55%) |7/35 (20%)   17/34 (50%)  21/41 (51%)  26/32 (81%)  | 
|FIRST INCIDENCE    |     511          554          439          572         |595          601          444          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183N     P=0.067N     P=0.303      P=0.097N    |P<0.001 **   P=0.023 *    P=0.042 *    P<0.001 **   | 
|POLY 3             |     P=0.208N     P=0.195N     P=0.386      P=0.162N    |P<0.001 **   P=0.011 *    P=0.009 **   P<0.001 **   | 
|POLY 1.5           |     P=0.185N     P=0.183N     P=0.431      P=0.141N    |P<0.001 **   P=0.012 *    P=0.008 **   P<0.001 **   | 
|POLY 6             |     P=0.240N     P=0.203N     P=0.337      P=0.189N    |P<0.001 **   P=0.012 *    P=0.012 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.163N     P=0.155N     P=0.534      P=0.117N    |P<0.001 **   P=0.015 *    P=0.010 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.159N     P=0.154N     P=0.500      P=0.111N    |P<0.001 **   P=0.018 *    P=0.011 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   7/50 (14%)   12/50 (24%)  9/50 (18%)  |3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/47.21      7/46.90      12/44.82     9/46.04     |3/44.21      1/43.59      2/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     12.7%        14.9%        26.8%        19.6%       |6.8%         2.3%         4.5%         2.3%         | 
|TERMINAL (d)       |     6/37 (16%)   7/43 (16%)   7/34 (21%)   9/40 (23%)  |3/35 (9%)    1/34 (3%)    2/41 (5%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      487          726 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.312      P=0.616      P=0.071      P=0.343     |P=0.378N     P=0.315N     P=0.428N     P=0.337N     | 
|POLY 3             |     P=0.272      P=0.495      P=0.074      P=0.269     |P=0.344N     P=0.310N     P=0.495N     P=0.304N     | 
|POLY 1.5           |     P=0.282      P=0.494      P=0.081      P=0.276     |P=0.345N     P=0.311N     P=0.502N     P=0.307N     | 
|POLY 6             |     P=0.260      P=0.503      P=0.069      P=0.264     |P=0.343N     P=0.308N     P=0.480N     P=0.301N     | 
|LOGISTIC REGRESSION|     P=0.281      P=0.616      P=0.082      P=0.343     |P=0.378N     P=0.315N     P=0.428N     P=0.337N     | 
|COCH-ARM / FISHERS |     P=0.296      P=0.500      P=0.096      P=0.288     |P=0.347N     P=0.309N     P=0.500N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   8/50 (16%)   4/50 (8%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     7/48.09      6/46.90      8/44.97      4/46.04     |2/44.21      2/43.59      3/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     14.6%        12.8%        17.8%        8.7%        |4.5%         4.6%         6.7%         2.3%         | 
|TERMINAL (d)       |     5/37 (14%)   6/43 (14%)   5/34 (15%)   4/40 (10%)  |2/35 (6%)    2/34 (6%)    3/41 (7%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     511          726 (T)      503          726 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.222N     P=0.408N     P=0.425      P=0.233N    |P=0.409N     P=0.685      P=0.572      P=0.531N     | 
|POLY 3             |     P=0.246N     P=0.519N     P=0.444      P=0.287N    |P=0.370N     P=0.689      P=0.505      P=0.499N     | 
|POLY 1.5           |     P=0.237N     P=0.515N     P=0.464      P=0.278N    |P=0.373N     P=0.688      P=0.498      P=0.502N     | 
|POLY 6             |     P=0.257N     P=0.518N     P=0.427      P=0.296N    |P=0.368N     P=0.691      P=0.520      P=0.496N     | 
|LOGISTIC REGRESSION|     P=0.220N     P=0.496N     P=0.609N     P=0.251N    |P=0.409N     P=0.685      P=0.572      P=0.531N     | 
|COCH-ARM / FISHERS |     P=0.225N     P=0.500N     P=0.500      P=0.262N    |P=0.373N     P=0.691N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  13/50 (26%)  19/50 (38%)  13/50 (26%) |5/50 (10%)   3/50 (6%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     12/48.09     13/46.90     19/46.44     13/46.04    |5/44.21      3/43.59      4/44.71      2/44.29      | 
|POLY-3 PERCENT (g) |     25.0%        27.7%        40.9%        28.2%       |11.3%        6.9%         9.0%         4.5%         | 
|TERMINAL (d)       |     10/37 (27%)  13/43 (30%)  11/34 (32%)  13/40 (33%) |5/35 (14%)   3/34 (9%)    4/41 (10%)   2/32 (6%)    | 
|FIRST INCIDENCE    |     511          726 (T)      487          726 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552N     P=0.528N     P=0.068      P=0.579     |P=0.262N     P=0.371N     P=0.401N     P=0.252N     | 
|POLY 3             |     P=0.481      P=0.471      P=0.074      P=0.450     |P=0.224N     P=0.364N     P=0.493N     P=0.215N     | 
|POLY 1.5           |     P=0.504      P=0.478      P=0.080      P=0.468     |P=0.227N     P=0.365N     P=0.503N     P=0.218N     | 
|POLY 6             |     P=0.454      P=0.472      P=0.072      P=0.431     |P=0.222N     P=0.360N     P=0.472N     P=0.211N     | 
|LOGISTIC REGRESSION|     P=0.528      P=0.492      P=0.131      P=0.471     |P=0.262N     P=0.371N     P=0.401N     P=0.252N     | 
|COCH-ARM / FISHERS |     P=0.535      P=0.500      P=0.097      P=0.500     |P=0.228N     P=0.357N     P=0.500N     P=0.218N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)   |8/50 (16%)   5/50 (10%)   5/50 (10%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/47.21      0/46.22      1/42.35      0/46.04     |8/44.88      5/43.59      5/44.71      5/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         0.0%        |17.8%        11.5%        11.2%        11.3%        | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    1/33 (3%)    0/40 (0%)   |6/35 (17%)   5/34 (15%)   5/41 (12%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     ---          ---          726 (T)      ---         |619          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.775N     (e)          P=0.477      (e)         |P=0.406N     P=0.291N     P=0.198N     P=0.327N     | 
|POLY 3             |     P=0.784N     (e)          P=0.478      (e)         |P=0.344N     P=0.294N     P=0.277N     P=0.283N     | 
|POLY 1.5           |     P=0.782N     (e)          P=0.485      (e)         |P=0.345N     P=0.291N     P=0.284N     P=0.284N     | 
|POLY 6             |     P=0.786N     (e)          P=0.472      (e)         |P=0.345N     P=0.297N     P=0.263N     P=0.284N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.477      (e)         |P=0.335N     P=0.281N     P=0.263N     P=0.271N     | 
|COCH-ARM / FISHERS |     P=0.780N     (e)          P=0.495      (e)         |P=0.346N     P=0.277N     P=0.277N     P=0.277N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)   |8/50 (16%)   5/50 (10%)   5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/47.21      0/46.22      1/42.35      0/46.04     |8/44.88      5/43.59      5/44.71      6/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         0.0%        |17.8%        11.5%        11.2%        13.6%        | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    1/33 (3%)    0/40 (0%)   |6/35 (17%)   5/34 (15%)   5/41 (12%)   6/32 (19%)   | 
|FIRST INCIDENCE    |     ---          ---          726 (T)      ---         |619          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.775N     (e)          P=0.477      (e)         |P=0.561N     P=0.291N     P=0.198N     P=0.447N     | 
|POLY 3             |     P=0.784N     (e)          P=0.478      (e)         |P=0.488N     P=0.294N     P=0.277N     P=0.396N     | 
|POLY 1.5           |     P=0.782N     (e)          P=0.485      (e)         |P=0.489N     P=0.291N     P=0.284N     P=0.397N     | 
|POLY 6             |     P=0.786N     (e)          P=0.472      (e)         |P=0.490N     P=0.297N     P=0.263N     P=0.398N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.477      (e)         |P=0.479N     P=0.281N     P=0.263N     P=0.380N     | 
|COCH-ARM / FISHERS |     P=0.780N     (e)          P=0.495      (e)         |P=0.489N     P=0.277N     P=0.277N     P=0.387N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.22      0/42.35      1/46.60     |0/44.21      3/43.59      1/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         2.2%        |0.0%         6.9%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    0/33 (0%)    0/40 (0%)   |0/35 (0%)    3/34 (9%)    1/41 (2%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          ---          554         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540      P=0.470N     P=0.523N     P=0.752N    |P=0.298N     P=0.116      P=0.532      (e)          | 
|POLY 3             |     P=0.537      P=0.504N     P=0.522N     P=0.758     |P=0.280N     P=0.116      P=0.502      (e)          | 
|POLY 1.5           |     P=0.538      P=0.505N     P=0.515N     P=0.758     |P=0.282N     P=0.116      P=0.499      (e)          | 
|POLY 6             |     P=0.534      P=0.501N     P=0.528N     P=0.758     |P=0.278N     P=0.117      P=0.509      (e)          | 
|LOGISTIC REGRESSION|     P=0.550      (e)          (e)          P=0.709N    |(e)          P=0.116      P=0.532      (e)          | 
|COCH-ARM / FISHERS |     P=0.538      P=0.505N     P=0.505N     P=0.753N    |P=0.280N     P=0.121      P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Rhabdomyosarcoma                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      0/46.04     |1/44.21      2/44.05      0/44.71      2/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.5%         0.0%         4.5%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |1/35 (3%)    1/34 (3%)    0/41 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      594          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.426      P=0.491      P=0.468N     P=0.469      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.454      P=0.499      P=0.498N     P=0.501      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.453      P=0.496      P=0.501N     P=0.498      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.455      P=0.503      P=0.491N     P=0.504      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.454      P=0.501      (e)          P=0.469      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.454      P=0.500      P=0.500N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      0/46.04     |1/44.45      1/43.84      2/44.71      1/44.57      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         2.3%         4.5%         2.2%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    2/41 (5%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |666          665          729 (T)      653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.644N     P=0.741N     P=0.551      P=0.746N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.632N     P=0.758      P=0.502      P=0.760N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.634N     P=0.757      P=0.497      P=0.760      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.631N     P=0.759      P=0.512      P=0.758N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.636N     P=0.757N     P=0.501      P=0.757N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.636N     P=0.753N     P=0.500      P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.88      2/46.90      2/43.60      0/46.04     |1/44.21      0/43.59      1/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         4.6%         0.0%        |2.3%         0.0%         2.2%         2.3%         | 
|TERMINAL (d)       |     0/37 (0%)    2/43 (5%)    1/34 (3%)    0/40 (0%)   |1/35 (3%)    0/34 (0%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     624          726 (T)      659          ---         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.166N     P=0.667N     P=0.648      P=0.255N    |P=0.536      P=0.506N     P=0.726N     P=0.742      | 
|POLY 3             |     P=0.161N     P=0.693N     P=0.667      P=0.241N    |P=0.563      P=0.503N     P=0.758N     P=0.760N     | 
|POLY 1.5           |     P=0.158N     P=0.692N     P=0.680      P=0.238N    |P=0.561      P=0.503N     P=0.759      P=0.759      | 
|POLY 6             |     P=0.165N     P=0.694N     P=0.654      P=0.245N    |P=0.564      P=0.502N     P=0.751N     P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.151N     P=0.674N     P=0.642N     P=0.182N    |P=0.536      (e)          P=0.726N     P=0.742      | 
|COCH-ARM / FISHERS |     P=0.154N     P=0.684N     P=0.684N     P=0.242N    |P=0.560      P=0.500N     P=0.747      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/47.21      2/46.90      0/43.35      1/46.04     |2/44.21      0/43.59      3/44.71      4/44.36      | 
|POLY-3 PERCENT (g) |     2.1%         4.3%         0.0%         2.2%        |4.5%         0.0%         6.7%         9.0%         | 
|TERMINAL (d)       |     1/37 (3%)    2/43 (5%)    0/34 (0%)    1/40 (3%)   |2/35 (6%)    0/34 (0%)    3/41 (7%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          726 (T)     |729 (T)      ---          729 (T)      712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.558N     P=0.552      P=0.517N     P=0.744N    |P=0.086      P=0.245N     P=0.572      P=0.304      | 
|POLY 3             |     P=0.567N     P=0.498      P=0.517N     P=0.755     |P=0.113      P=0.240N     P=0.505      P=0.338      | 
|POLY 1.5           |     P=0.566N     P=0.497      P=0.511N     P=0.757     |P=0.111      P=0.241N     P=0.498      P=0.335      | 
|POLY 6             |     P=0.568N     P=0.501      P=0.523N     P=0.754     |P=0.114      P=0.239N     P=0.520      P=0.343      | 
|LOGISTIC REGRESSION|     P=0.558N     P=0.552      (e)          P=0.744N    |P=0.108      (e)          P=0.572      P=0.341      | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.500      P=0.500N     P=0.753N    |P=0.111      P=0.247N     P=0.500      P=0.339      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      1/42.55      0/46.04     |0/44.21      0/43.59      1/44.86      3/44.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.4%         0.0%        |0.0%         0.0%         2.2%         6.7%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    1/34 (3%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          726 (T)      ---         |---          ---          692          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.459N     P=0.470N     P=0.743      P=0.484N    |P=0.022 *    (e)          P=0.525      P=0.122      | 
|POLY 3             |     P=0.467N     P=0.501N     P=0.737      P=0.505N    |P=0.023 *    (e)          P=0.503      P=0.120      | 
|POLY 1.5           |     P=0.465N     P=0.502N     P=0.744      P=0.503N    |P=0.022 *    (e)          P=0.499      P=0.119      | 
|POLY 6             |     P=0.470N     P=0.499N     P=0.731      P=0.506N    |P=0.023 *    (e)          P=0.510      P=0.123      | 
|LOGISTIC REGRESSION|     P=0.459N     (e)          P=0.743      (e)         |P=0.023 *    (e)          P=0.500      P=0.120      | 
|COCH-ARM / FISHERS |     P=0.464N     P=0.500N     P=0.747      P=0.500N    |P=0.022 *    (e)          P=0.500      P=0.121      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      1/42.55      0/46.04     |1/44.21      0/43.59      1/44.86      3/44.64      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.4%         0.0%        |2.3%         0.0%         2.2%         6.7%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    1/34 (3%)    0/40 (0%)   |1/35 (3%)    0/34 (0%)    0/41 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          726 (T)      ---         |729 (T)      ---          692          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.459N     P=0.470N     P=0.743      P=0.484N    |P=0.078      P=0.506N     P=0.728N     P=0.296      | 
|POLY 3             |     P=0.467N     P=0.501N     P=0.737      P=0.505N    |P=0.084      P=0.503N     P=0.757N     P=0.309      | 
|POLY 1.5           |     P=0.465N     P=0.502N     P=0.744      P=0.503N    |P=0.083      P=0.503N     P=0.760      P=0.305      | 
|POLY 6             |     P=0.470N     P=0.499N     P=0.731      P=0.506N    |P=0.085      P=0.502N     P=0.750N     P=0.314      | 
|LOGISTIC REGRESSION|     P=0.459N     (e)          P=0.743      (e)         |P=0.082      (e)          P=0.761N     P=0.304      | 
|COCH-ARM / FISHERS |     P=0.464N     P=0.500N     P=0.747      P=0.500N    |P=0.082      P=0.500N     P=0.753N     P=0.309      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Leiomyosarcoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.21      1/43.59      0/44.71      2/44.76      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.3%         0.0%         4.5%         | 
|TERMINAL (d)       |                                                        |0/35 (0%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          729 (T)      ---          595          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.140      P=0.494      (e)          P=0.234      | 
|POLY 3             |                                                        |P=0.150      P=0.497      (e)          P=0.240      | 
|POLY 1.5           |                                                        |P=0.149      P=0.497      (e)          P=0.237      | 
|POLY 6             |                                                        |P=0.152      P=0.498      (e)          P=0.243      | 
|LOGISTIC REGRESSION|                                                        |P=0.149      P=0.494      (e)          P=0.243      | 
|COCH-ARM / FISHERS |                                                        |P=0.149      P=0.500      (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.21      0/43.59      3/44.71      1/44.68      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         0.0%         6.7%         2.2%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    0/34 (0%)    3/41 (7%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      619          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.567      P=0.506N     P=0.363      P=0.748      | 
|POLY 3             |                                                        |P=0.602      P=0.503N     P=0.309      P=0.758N     | 
|POLY 1.5           |                                                        |P=0.596      P=0.503N     P=0.303      P=0.760      | 
|POLY 6             |                                                        |P=0.609      P=0.502N     P=0.321      P=0.755N     | 
|LOGISTIC REGRESSION|                                                        |P=0.593      (e)          P=0.363      P=0.760N     | 
|COCH-ARM / FISHERS |                                                        |P=0.592      P=0.500N     P=0.309      P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.21      1/46.90      0/43.35      2/46.04     |1/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         4.3%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    1/43 (2%)    0/34 (0%)    2/40 (5%)   |1/35 (3%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          726 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.338      P=0.728N     P=0.517N     P=0.527     |P=0.515N     P=0.506N     P=0.468N     P=0.518N     | 
|POLY 3             |     P=0.325      P=0.759      P=0.517N     P=0.491     |P=0.499N     P=0.503N     P=0.498N     P=0.500N     | 
|POLY 1.5           |     P=0.327      P=0.759      P=0.511N     P=0.494     |P=0.498N     P=0.503N     P=0.501N     P=0.501N     | 
|POLY 6             |     P=0.323      P=0.760N     P=0.523N     P=0.489     |P=0.501N     P=0.502N     P=0.491N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.338      P=0.728N     (e)          P=0.527     |P=0.515N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.329      P=0.753N     P=0.500N     P=0.500     |P=0.500N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    9/50 (18%)   2/50 (4%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/47.72      2/46.90      9/44.70      2/46.42     |3/44.60      1/43.59      1/44.71      2/44.34      | 
|POLY-3 PERCENT (g) |     6.3%         4.3%         20.1%        4.3%        |6.7%         2.3%         2.2%         4.5%         | 
|TERMINAL (d)       |     1/37 (3%)    2/43 (5%)    5/34 (15%)   1/40 (3%)   |2/35 (6%)    1/34 (3%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     624          726 (T)      517          618         |619          729 (T)      729 (T)      717          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430N     P=0.461N     P=0.048 *    P=0.502N    |P=0.628      P=0.316N     P=0.268N     P=0.529N     | 
|POLY 3             |     P=0.442N     P=0.508N     P=0.046 *    P=0.513N    |P=0.613N     P=0.313N     P=0.304N     P=0.503N     | 
|POLY 1.5           |     P=0.434N     P=0.506N     P=0.051      P=0.508N    |P=0.614N     P=0.313N     P=0.309N     P=0.504N     | 
|POLY 6             |     P=0.451N     P=0.507N     P=0.042 *    P=0.517N    |P=0.613N     P=0.313N     P=0.295N     P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.415N     P=0.491N     P=0.080      P=0.449N    |P=0.614N     P=0.309N     P=0.306N     P=0.501N     | 
|COCH-ARM / FISHERS |     P=0.425N     P=0.500N     P=0.061      P=0.500N    |P=0.616N     P=0.309N     P=0.309N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    9/50 (18%)   4/50 (8%)   |4/50 (8%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/47.72      3/46.90      9/44.70      4/46.42     |4/44.60      1/43.59      1/44.71      2/44.34      | 
|POLY-3 PERCENT (g) |     8.4%         6.4%         20.1%        8.6%        |9.0%         2.3%         2.2%         4.5%         | 
|TERMINAL (d)       |     2/37 (5%)    3/43 (7%)    5/34 (15%)   3/40 (8%)   |3/35 (9%)    1/34 (3%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     624          726 (T)      517          618         |619          729 (T)      729 (T)      717          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566      P=0.444N     P=0.092      P=0.626N    |P=0.515N     P=0.190N     P=0.147N     P=0.371N     | 
|POLY 3             |     P=0.550      P=0.509N     P=0.092      P=0.628     |P=0.477N     P=0.185N     P=0.178N     P=0.340N     | 
|POLY 1.5           |     P=0.557      P=0.508N     P=0.100      P=0.633     |P=0.478N     P=0.185N     P=0.182N     P=0.342N     | 
|POLY 6             |     P=0.540      P=0.508N     P=0.085      P=0.623     |P=0.478N     P=0.185N     P=0.169N     P=0.338N     | 
|LOGISTIC REGRESSION|     P=0.573      P=0.499N     P=0.141      P=0.625N    |P=0.478N     P=0.183N     P=0.178N     P=0.336N     | 
|COCH-ARM / FISHERS |     P=0.568      P=0.500N     P=0.117      P=0.643N    |P=0.482N     P=0.181N     P=0.181N     P=0.339N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |4/50 (8%)    5/50 (10%)   0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.96      0/43.35      2/46.20     |4/45.59      5/45.24      0/44.71      3/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         4.3%        |8.8%         11.1%        0.0%         6.7%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    1/40 (3%)   |0/35 (0%)    2/34 (6%)    0/41 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          710          ---          684         |617          444          ---          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.150      P=0.514      (e)          P=0.241     |P=0.409N     P=0.498      P=0.067N     P=0.515N     | 
|POLY 3             |     P=0.147      P=0.499      (e)          P=0.232     |P=0.396N     P=0.495      P=0.063N     P=0.506N     | 
|POLY 1.5           |     P=0.148      P=0.498      (e)          P=0.234     |P=0.396N     P=0.494      P=0.063N     P=0.507N     | 
|POLY 6             |     P=0.146      P=0.501      (e)          P=0.232     |P=0.398N     P=0.494      P=0.061N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.149      P=0.499      (e)          P=0.237     |P=0.381N     P=0.565      P=0.050N     P=0.470N     | 
|COCH-ARM / FISHERS |     P=0.150      P=0.500      (e)          P=0.247     |P=0.395N     P=0.500      P=0.059N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |8/50 (16%)   9/50 (18%)   6/50 (12%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      1/43.35      1/46.04     |8/44.21      9/44.42      6/45.55      8/44.90      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         2.2%        |18.1%        20.3%        13.2%        17.8%        | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    1/34 (3%)    1/40 (3%)   |8/35 (23%)   6/34 (18%)   3/41 (7%)    6/32 (19%)   | 
|FIRST INCIDENCE    |     ---          ---          726 (T)      726 (T)     |729 (T)      610          586          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.322      (e)          P=0.483      P=0.516     |P=0.541      P=0.483      P=0.288N     P=0.541      | 
|POLY 3             |     P=0.307      (e)          P=0.483      P=0.495     |P=0.530N     P=0.504      P=0.363N     P=0.595N     | 
|POLY 1.5           |     P=0.311      (e)          P=0.489      P=0.497     |P=0.536N     P=0.494      P=0.383N     P=0.606N     | 
|POLY 6             |     P=0.303      (e)          P=0.477      P=0.494     |P=0.527N     P=0.523      P=0.329N     P=0.581N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.483      P=0.516     |P=0.536N     P=0.491      P=0.378N     P=0.600N     | 
|COCH-ARM / FISHERS |     P=0.315      (e)          P=0.500      P=0.500     |P=0.540N     P=0.500      P=0.387N     P=0.607N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/50 (60%)  25/50 (50%)  32/50 (64%)  32/50 (64%) |24/50 (48%)  28/50 (56%)  27/50 (54%)  38/50 (76%)  | 
|POLY-3 RATE (b)    |     30/48.13     25/46.90     32/45.49     32/48.33    |24/45.52     28/44.74     27/46.13     38/47.60     | 
|POLY-3 PERCENT (g) |     62.3%        53.3%        70.4%        66.2%       |52.7%        62.6%        58.5%        79.8%        | 
|TERMINAL (d)       |     27/37 (73%)  25/43 (58%)  23/34 (68%)  27/40 (68%) |20/35 (57%)  23/34 (68%)  24/41 (59%)  27/32 (84%)  | 
|FIRST INCIDENCE    |     511          726 (T)      487          399         |617          594          444          70           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.254      P=0.043N*    P=0.231      P=0.578     |P<0.001 **   P=0.241      P=0.536N     P=0.003 **   | 
|POLY 3             |     P=0.241      P=0.245N     P=0.269      P=0.426     |P=0.003 **   P=0.226      P=0.362      P=0.003 **   | 
|POLY 1.5           |     P=0.232      P=0.237N     P=0.317      P=0.421     |P=0.003 **   P=0.232      P=0.335      P=0.003 **   | 
|POLY 6             |     P=0.252      P=0.240N     P=0.247      P=0.440     |P=0.004 **   P=0.225      P=0.410      P=0.004 **   | 
|LOGISTIC REGRESSION|     P=0.179      P=0.199N     P=0.209      P=0.390     |P=0.002 **   P=0.248      P=0.348      P=0.003 **   | 
|COCH-ARM / FISHERS |     P=0.215      P=0.211N     P=0.418      P=0.418     |P=0.003 **   P=0.274      P=0.345      P=0.004 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  TRIETHANOLAMINE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  24/50 (48%)  27/50 (54%)  21/50 (42%) |27/50 (54%)  26/50 (52%)  16/50 (32%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     28/50.00     24/48.24     27/48.83     21/48.31    |27/48.01     26/47.70     16/46.06     21/46.59     | 
|POLY-3 PERCENT (g) |     56.0%        49.8%        55.3%        43.5%       |56.2%        54.5%        34.7%        45.1%        | 
|TERMINAL (d)       |     16/37 (43%)  20/43 (47%)  14/34 (41%)  14/40 (35%) |16/35 (46%)  14/34 (41%)  12/41 (29%)  12/32 (38%)  | 
|FIRST INCIDENCE    |     511          554          439          566         |532          444          573          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.174N     P=0.169N     P=0.454      P=0.135N    |P=0.261N     P=0.521N     P=0.015N*    P=0.270N     | 
|POLY 3             |     P=0.150N     P=0.339N     P=0.552N     P=0.149N    |P=0.179N     P=0.514N     P=0.027N*    P=0.188N     | 
|POLY 1.5           |     P=0.141N     P=0.318N     P=0.532N     P=0.136N    |P=0.170N     P=0.521N     P=0.026N*    P=0.181N     | 
|POLY 6             |     P=0.160N     P=0.357N     P=0.574N     P=0.163N    |P=0.196N     P=0.505N     P=0.028N*    P=0.203N     | 
|LOGISTIC REGRESSION|     P=0.112N     P=0.263N     P=0.291N     P=0.088N    |P=0.159N     P=0.495N     P=0.022N*    P=0.160N     | 
|COCH-ARM / FISHERS |     P=0.128N     P=0.274N     P=0.500N     P=0.115N    |P=0.158N     P=0.500N     P=0.021N*    P=0.158N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  35/50 (70%)  43/50 (86%)  41/50 (82%) |38/50 (76%)  41/50 (82%)  35/50 (70%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     45/50.00     35/48.24     43/49.23     41/49.70    |38/48.01     41/48.06     35/47.33     44/49.06     | 
|POLY-3 PERCENT (g) |     90.0%        72.6%        87.4%        82.5%       |79.2%        85.3%        74.0%        89.7%        | 
|TERMINAL (d)       |     33/37 (89%)  31/43 (72%)  28/34 (82%)  32/40 (80%) |27/35 (77%)  27/34 (79%)  29/41 (71%)  29/32 (91%)  | 
|FIRST INCIDENCE    |     511          554          439          399         |532          444          444          70           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.516N     P=0.005N**   P=0.421      P=0.180N    |P=0.084      P=0.332      P=0.123N     P=0.104      | 
|POLY 3             |     P=0.518N     P=0.022N*    P=0.460N     P=0.212N    |P=0.122      P=0.300      P=0.359N     P=0.119      | 
|POLY 1.5           |     P=0.530N     P=0.017N*    P=0.433N     P=0.204N    |P=0.115      P=0.278      P=0.370N     P=0.109      | 
|POLY 6             |     P=0.518N     P=0.027N*    P=0.479N     P=0.225N    |P=0.125      P=0.337      P=0.339N     P=0.129      | 
|LOGISTIC REGRESSION|     P=0.556      P=0.014N*    P=0.353N     P=0.175N    |P=0.088      P=0.260      P=0.352N     P=0.088      | 
|COCH-ARM / FISHERS |     P=0.559      P=0.011N*    P=0.380N     P=0.194N    |P=0.095      P=0.312      P=0.326N     P=0.096      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).