National Toxicology Program

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TDMS Study 05109-14 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                      TRIETHANOLAMINE                                    DATE: 06/06/02       
EXPERIMENT: 05109 TEST: 14                                                                                     TIME: 08:42:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85427                              ROUTE: SKIN APPLICATION                                        NTP C#: 61621E       
PATHOLOGIST: MISSING                                                                                           CAS: 102-71-6        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                      TRIETHANOLAMINE                                    DATE: 06/06/02       
EXPERIMENT: 05109 TEST: 14                                                                                     TIME: 08:42:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85427                              ROUTE: SKIN APPLICATION                                        NTP C#: 61621E       
PATHOLOGIST: MISSING                                                                                           CAS: 102-71-6        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                 TRIETHANOLAMINE                                                                                  
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia Focal                                                                            
                                       Hypertrophy Focal                                                                            
Adrenal Medulla                        Hyperplasia Focal                                                                            
Heart                                  Inflammation Chronic                                                                         
Heart: Artery                          Inflammation Chronic                                                                         
Islets, Pancreatic                     Hyperplasia                                                                                  
Liver                                  Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
Preputial Gland                        Inflammation                                                                                 
Skin: Site of Application - Epidermis  Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Ulcer                                                                                        
Skin: Subcutaneous Tissue, Site of Application - Dermis                                                                             
                                       Inflammation Chronic                                                                         
Spleen                                 Atrophy                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Kidney                                 Metaplasia Osseous                                                                           
Liver                                  Eosinophilic Focus                                                                           
                                       Infiltration Cellular Lymphoid                                                               
                                       Inflammation Chronic                                                                         
                                       Mixed Cell Focus                                                                             
                                       Necrosis Focal                                                                               
                                       Vacuolization Cytoplasmic Focal                                                              
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Skin: Site of Application - Epidermis  Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Ulcer                                                                                        
Skin: Subcutaneous Tissue, Site of Application - Dermis                                                                             
                                       Inflammation Chronic                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                  TRIETHANOLAMINE      
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   4/50 (8%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     8/47.57      4/47.22      3/43.85      1/46.39     |1/44.21      1/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     16.8%        8.5%         6.8%         2.2%        |2.3%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     6/37 (16%)   3/43 (7%)    1/34 (3%)    0/40 (0%)   |1/35 (3%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     664          637          614          628         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028N*    P=0.134N     P=0.142N     P=0.018N*   |P=0.337N     P=0.755      P=0.468N     P=0.518N     | 
|POLY 3             |     P=0.023N*    P=0.181N     P=0.126N     P=0.017N*   |P=0.325N     P=0.758      P=0.498N     P=0.500N     | 
|POLY 1.5           |     P=0.023N*    P=0.182N     P=0.116N     P=0.017N*   |P=0.325N     P=0.757      P=0.501N     P=0.501N     | 
|POLY 6             |     P=0.024N*    P=0.176N     P=0.136N     P=0.018N*   |P=0.326N     P=0.759      P=0.491N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.023N*    P=0.180N     P=0.113N     P=0.017N*   |P=0.337N     P=0.755      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.024N*    P=0.178N     P=0.100N     P=0.015N*   |P=0.325N     P=0.753N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  21/50 (42%)  10/50 (20%)  10/50 (20%) |0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     16/47.21     21/47.29     10/43.43     10/46.04    |0/44.21      2/43.59      1/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     33.9%        44.4%        23.0%        21.7%       |0.0%         4.6%         2.2%         2.3%         | 
|TERMINAL (d)       |     15/37 (41%)  20/43 (47%)  9/34 (27%)   10/40 (25%) |0/35 (0%)    2/34 (6%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     725          615          705          726 (T)     |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026N*    P=0.387      P=0.182N     P=0.080N    |P=0.603      P=0.232      P=0.532      P=0.482      | 
|POLY 3             |     P=0.033N*    P=0.200      P=0.180N     P=0.139N    |P=0.627      P=0.234      P=0.502      P=0.500      | 
|POLY 1.5           |     P=0.032N*    P=0.197      P=0.159N     P=0.135N    |P=0.625      P=0.234      P=0.499      P=0.499      | 
|POLY 6             |     P=0.035N*    P=0.216      P=0.201N     P=0.141N    |P=0.630      P=0.235      P=0.509      P=0.502      | 
|LOGISTIC REGRESSION|     P=0.040N*    P=0.218      P=0.223N     P=0.080N    |(e)          P=0.232      P=0.532      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.033N*    P=0.204      P=0.127N     P=0.127N    |P=0.627      P=0.247      P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     39/50 (78%)  45/50 (90%)  40/50 (80%)  40/50 (80%) |49/50 (98%)  49/50 (98%)  50/50 (100%) 50/50 (100%) | 
|POLY-3 RATE (b)    |     39/48.72     45/49.33     40/48.45     40/48.55    |49/50.00     49/49.83     50/50.00     50/50.00     | 
|POLY-3 PERCENT (g) |     80.1%        91.2%        82.6%        82.4%       |98.0%        98.3%        100.0%       100.0%       | 
|TERMINAL (d)       |     30/37 (81%)  39/43 (91%)  27/34 (79%)  34/40 (85%) |34/35 (97%)  34/34 (100%) 41/41 (100%) 32/32 (100%) | 
|FIRST INCIDENCE    |     580          334          443          399         |329          221          62           70           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381N     P=0.522      P=0.257      P=0.482N    |P=0.235      P=0.507      P=0.208N     P=0.308      | 
|POLY 3             |     P=0.425N     P=0.091      P=0.477      P=0.485     |P=0.341      P=0.739      P=0.500      P=0.500      | 
|POLY 1.5           |     P=0.406N     P=0.086      P=0.478      P=0.493     |P=0.333      P=0.750      P=0.500      P=0.500      | 
|POLY 6             |     P=0.463N     P=0.107      P=0.497      P=0.470     |P=0.357      P=0.717      P=0.500      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.412N     P=0.070      P=0.405      P=0.439     |P=0.324      P=0.760N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.394N     P=0.086      P=0.500      P=0.500     |P=0.325      P=0.753N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Zona Glomerulosa                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      2/47.09      3/43.35      1/46.04     |0/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         6.9%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    3/34 (9%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          676          726 (T)      726 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.635      P=0.256      P=0.106      P=0.516     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.619      P=0.237      P=0.104      P=0.495     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.624      P=0.236      P=0.110      P=0.497     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.613      P=0.240      P=0.099      P=0.494     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.623      P=0.240      P=0.106      P=0.516     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.633      P=0.247      P=0.121      P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/49 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      2/46.04     |0/43.28      1/43.59      1/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.3%        |0.0%         2.3%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    2/40 (5%)   |0/35 (0%)    1/34 (3%)    1/41 (2%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          726 (T)     |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    (e)          (e)          P=0.256     |P=0.559N     P=0.494      P=0.532      (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.232     |P=0.533N     P=0.501      P=0.506      (e)          | 
|POLY 1.5           |     P=0.040 *    (e)          (e)          P=0.234     |P=0.535N     P=0.501      P=0.503      (e)          | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.230     |P=0.532N     P=0.502      P=0.513      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.256     |(e)          P=0.494      P=0.532      (e)          | 
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |P=0.534N     P=0.505      P=0.505      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      1/46.34     |0/44.21      0/43.59      2/45.61      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    1/41 (2%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          644         |---          ---          338          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.216      (e)          (e)          P=0.491     |P=0.686N     (e)          P=0.257      (e)          | 
|POLY 3             |     P=0.216      (e)          (e)          P=0.496     |P=0.673N     (e)          P=0.244      (e)          | 
|POLY 1.5           |     P=0.217      (e)          (e)          P=0.497     |P=0.676N     (e)          P=0.239      (e)          | 
|POLY 6             |     P=0.214      (e)          (e)          P=0.496     |P=0.671N     (e)          P=0.252      (e)          | 
|LOGISTIC REGRESSION|     P=0.216      (e)          (e)          P=0.554     |P=0.651N     (e)          P=0.298      (e)          | 
|COCH-ARM / FISHERS |     P=0.218      (e)          (e)          P=0.500     |P=0.675N     (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta                                                                                                              | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.90      0/43.35      0/46.04     |1/44.45      2/44.69      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |2.3%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          ---         |666          221          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.585N     P=0.530      (e)          (e)         |P=0.224N     P=0.503      P=0.475N     P=0.485N     | 
|POLY 3             |     P=0.590N     P=0.499      (e)          (e)         |P=0.229N     P=0.502      P=0.499N     P=0.501N     | 
|POLY 1.5           |     P=0.590N     P=0.498      (e)          (e)         |P=0.229N     P=0.500      P=0.502N     P=0.502N     | 
|POLY 6             |     P=0.588N     P=0.501      (e)          (e)         |P=0.229N     P=0.504      P=0.493N     P=0.500N     | 
|LOGISTIC REGRESSION|     (e)          P=0.530      (e)          (e)         |P=0.193N     P=0.628      P=0.495N     P=0.495N     | 
|COCH-ARM / FISHERS |     P=0.590N     P=0.500      (e)          (e)         |P=0.228N     P=0.500      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |7/50 (14%)   6/50 (12%)   13/50 (26%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      1/43.35      0/46.04     |7/44.61      6/44.04      13/45.23     10/44.59     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |15.7%        13.6%        28.7%        22.4%        | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    1/34 (3%)    0/40 (0%)   |6/35 (17%)   4/34 (12%)   12/41 (29%)  8/32 (25%)   | 
|FIRST INCIDENCE    |     ---          ---          726 (T)      ---         |617          665          573          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.776N     (e)          P=0.483      (e)         |P=0.170      P=0.509N     P=0.181      P=0.242      | 
|POLY 3             |     P=0.786N     (e)          P=0.483      (e)         |P=0.233      P=0.510N     P=0.107      P=0.295      | 
|POLY 1.5           |     P=0.784N     (e)          P=0.489      (e)         |P=0.230      P=0.512N     P=0.100      P=0.291      | 
|POLY 6             |     P=0.787N     (e)          P=0.477      (e)         |P=0.234      P=0.503N     P=0.122      P=0.299      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.483      (e)         |P=0.237      P=0.509N     P=0.112      P=0.303      | 
|COCH-ARM / FISHERS |     P=0.782N     (e)          P=0.500      (e)         |P=0.233      P=0.500N     P=0.105      P=0.298      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain: Hypothalamus                                                                                                              | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    3/49 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      0/46.04     |0/44.21      0/43.59      3/43.71      1/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         6.9%         2.3%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    3/40 (8%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.391      (e)          P=0.146      P=0.482      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.428      (e)          P=0.116      P=0.500      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.424      (e)          P=0.114      P=0.499      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.433      (e)          P=0.122      P=0.502      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.146      P=0.482      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.424      (e)          P=0.117      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/44.45      0/43.25      0/44.49      1/43.82      | 
|POLY-3 PERCENT (g) |                                                        |4.5%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |666          ---          ---          712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.677N     P=0.237N     P=0.209N     P=0.502N     | 
|POLY 3             |                                                        |P=0.675N     P=0.243N     P=0.237N     P=0.505N     | 
|POLY 1.5           |                                                        |P=0.674N     P=0.244N     P=0.241N     P=0.508N     | 
|POLY 6             |                                                        |P=0.677N     P=0.242N     P=0.230N     P=0.501N     | 
|LOGISTIC REGRESSION|                                                        |P=0.675N     P=0.243N     P=0.242N     P=0.507N     | 
|COCH-ARM / FISHERS |                                                        |P=0.675N     P=0.253N     P=0.253N     P=0.508N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      1/43.35      2/46.20     |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.3%         4.3%        |                                                    | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    1/34 (3%)    1/40 (3%)   |                                                    | 
|FIRST INCIDENCE    |     726 (T)      ---          726 (T)      684         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240      P=0.470N     P=0.743      P=0.510     |                                                    | 
|POLY 3             |     P=0.232      P=0.501N     P=0.741      P=0.493     |                                                    | 
|POLY 1.5           |     P=0.234      P=0.502N     P=0.748      P=0.495     |                                                    | 
|POLY 6             |     P=0.229      P=0.499N     P=0.734      P=0.491     |                                                    | 
|LOGISTIC REGRESSION|     P=0.231      (e)          P=0.743      P=0.494     |                                                    | 
|COCH-ARM / FISHERS |     P=0.235      P=0.500N     P=0.753N     P=0.500     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   6/49 (12%)   7/50 (14%)  |4/49 (8%)    3/50 (6%)    4/50 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     3/47.21      5/47.85      6/43.07      7/46.51     |4/44.06      3/43.59      4/44.71      5/44.82      | 
|POLY-3 PERCENT (g) |     6.4%         10.5%        13.9%        15.1%       |9.1%         6.9%         9.0%         11.2%        | 
|TERMINAL (d)       |     3/37 (8%)    3/43 (7%)    5/34 (15%)   5/40 (13%)  |3/35 (9%)    3/34 (9%)    4/41 (10%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     726 (T)      554          705          644         |619          729 (T)      729 (T)      595          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.182      P=0.418      P=0.200      P=0.184     |P=0.308      P=0.515N     P=0.567N     P=0.462      | 
|POLY 3             |     P=0.160      P=0.364      P=0.199      P=0.151     |P=0.371      P=0.506N     P=0.635N     P=0.511      | 
|POLY 1.5           |     P=0.165      P=0.359      P=0.211      P=0.154     |P=0.367      P=0.503N     P=0.640N     P=0.508      | 
|POLY 6             |     P=0.157      P=0.376      P=0.188      P=0.152     |P=0.375      P=0.509N     P=0.624N     P=0.514      | 
|LOGISTIC REGRESSION|     P=0.167      P=0.377      P=0.177      P=0.150     |P=0.364      P=0.500N     P=0.628N     P=0.509      | 
|COCH-ARM / FISHERS |     P=0.170      P=0.357      P=0.233      P=0.159     |P=0.364      P=0.489N     P=0.631N     P=0.513      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.44      1/47.29      0/43.35      0/46.04     |0/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     6.3%         2.1%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/37 (5%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     664          615          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.110N     P=0.285N     P=0.142N     P=0.118N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.103N     P=0.307N     P=0.136N     P=0.124N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.102N     P=0.308N     P=0.129N     P=0.122N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.104N     P=0.302N     P=0.143N     P=0.126N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.100N     P=0.278N     P=0.127N     P=0.120N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.309N     P=0.121N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      2/46.04     |0/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    2/40 (5%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          726 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    (e)          (e)          P=0.256     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.232     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.040 *    (e)          (e)          P=0.234     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.230     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.256     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Artery                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.90      0/43.35      3/46.04     |3/44.21      1/43.84      2/45.61      1/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         6.5%        |6.8%         2.3%         4.4%         2.3%         | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    3/40 (8%)   |3/35 (9%)    0/34 (0%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          726 (T)     |729 (T)      665          338          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    P=0.530      (e)          P=0.135     |P=0.369N     P=0.303N     P=0.443N     P=0.337N     | 
|POLY 3             |     P=0.039 *    P=0.499      (e)          P=0.114     |P=0.346N     P=0.308N     P=0.486N     P=0.304N     | 
|POLY 1.5           |     P=0.039 *    P=0.498      (e)          P=0.116     |P=0.346N     P=0.310N     P=0.496N     P=0.307N     | 
|POLY 6             |     P=0.038 *    P=0.501      (e)          P=0.113     |P=0.346N     P=0.304N     P=0.470N     P=0.301N     | 
|LOGISTIC REGRESSION|     (e)          P=0.530      (e)          P=0.135     |P=0.344N     P=0.309N     P=0.477N     P=0.337N     | 
|COCH-ARM / FISHERS |     P=0.041 *    P=0.500      (e)          P=0.121     |P=0.347N     P=0.309N     P=0.500N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.44      1/47.09      0/43.35      0/46.04     |2/44.26      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |1/35 (3%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     664          676          ---          ---         |717          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.326N     P=0.758      P=0.528N     P=0.513N    |P=0.267N     P=0.249N     P=0.209N     P=0.253N     | 
|POLY 3             |     P=0.315N     P=0.759      P=0.518N     P=0.506N    |P=0.259N     P=0.240N     P=0.235N     P=0.237N     | 
|POLY 1.5           |     P=0.315N     P=0.758      P=0.511N     P=0.504N    |P=0.258N     P=0.241N     P=0.239N     P=0.238N     | 
|POLY 6             |     P=0.316N     P=0.760N     P=0.525N     P=0.508N    |P=0.260N     P=0.239N     P=0.228N     P=0.235N     | 
|LOGISTIC REGRESSION|     P=0.307N     P=0.742N     P=0.456N     P=0.466N    |P=0.259N     P=0.239N     P=0.222N     P=0.234N     | 
|COCH-ARM / FISHERS |     P=0.315N     P=0.753N     P=0.500N     P=0.500N    |P=0.262N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/47.80      0/43.35      0/46.04     |4/44.66      0/43.59      1/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |9.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |1/35 (3%)    0/34 (0%)    1/41 (2%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          334          ---          ---         |640          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.590N     P=0.500      (e)          (e)         |P=0.105N     P=0.072N     P=0.152N     P=0.072N     | 
|POLY 3             |     P=0.587N     P=0.503      (e)          (e)         |P=0.095N     P=0.063N     P=0.178N     P=0.061N     | 
|POLY 1.5           |     P=0.588N     P=0.501      (e)          (e)         |P=0.096N     P=0.063N     P=0.182N     P=0.062N     | 
|POLY 6             |     P=0.586N     P=0.505      (e)          (e)         |P=0.095N     P=0.063N     P=0.171N     P=0.061N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.101N     P=0.064N     P=0.179N     P=0.063N     | 
|COCH-ARM / FISHERS |     P=0.590N     P=0.500      (e)          (e)         |P=0.101N     P=0.059N     P=0.181N     P=0.059N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      1/43.35      2/46.20     |1/44.61      2/44.69      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.3%         4.3%        |2.2%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    1/34 (3%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     725          ---          726 (T)      684         |617          221          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.239      P=0.481N     P=0.736      P=0.504     |P=0.228N     P=0.489      P=0.513N     P=0.509N     | 
|POLY 3             |     P=0.232      P=0.501N     P=0.741      P=0.493     |P=0.229N     P=0.501      P=0.500N     P=0.501N     | 
|POLY 1.5           |     P=0.234      P=0.502N     P=0.748      P=0.495     |P=0.229N     P=0.500      P=0.502N     P=0.502N     | 
|POLY 6             |     P=0.229      P=0.499N     P=0.734      P=0.491     |P=0.230N     P=0.502      P=0.494N     P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.231      P=0.489N     P=0.731      P=0.494     |P=0.187N     P=0.645      P=0.475N     P=0.477N     | 
|COCH-ARM / FISHERS |     P=0.235      P=0.500N     P=0.753N     P=0.500     |P=0.228N     P=0.500      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  43/50 (86%)  43/50 (86%)  32/50 (64%) |25/50 (50%)  18/50 (36%)  20/50 (40%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     45/48.99     43/49.33     43/49.39     32/49.53    |25/47.37     18/45.44     20/45.76     18/44.62     | 
|POLY-3 PERCENT (g) |     91.9%        87.2%        87.1%        64.6%       |52.8%        39.6%        43.7%        40.3%        | 
|TERMINAL (d)       |     35/37 (95%)  37/43 (86%)  29/34 (85%)  24/40 (60%) |17/35 (49%)  12/34 (35%)  18/41 (44%)  16/32 (50%)  | 
|FIRST INCIDENCE    |     511          334          439          399         |469          594          338          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006N**   P=0.087N     P=0.424      P=0.007N**  |P=0.316N     P=0.161N     P=0.102N     P=0.193N     | 
|POLY 3             |     P<0.001N**   P=0.329N     P=0.323N     P<0.001N**  |P=0.256N     P=0.141N     P=0.251N     P=0.159N     | 
|POLY 1.5           |     P<0.001N**   P=0.357N     P=0.349N     P<0.001N**  |P=0.236N     P=0.136N     P=0.244N     P=0.143N     | 
|POLY 6             |     P<0.001N**   P=0.279N     P=0.282N     P<0.001N**  |P=0.289N     P=0.143N     P=0.250N     P=0.183N     | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.419N     P=0.418N     P=0.002N**  |P=0.204N     P=0.118N     P=0.216N     P=0.113N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.380N     P=0.380N     P=0.002N**  |P=0.209N     P=0.113N     P=0.211N     P=0.113N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/50 (4%)    4/50 (8%)   |1/50 (2%)    5/50 (10%)   3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/47.21      3/46.90      2/43.54      4/46.04     |1/44.21      5/43.97      3/44.71      3/44.34      | 
|POLY-3 PERCENT (g) |     4.2%         6.4%         4.6%         8.7%        |2.3%         11.4%        6.7%         6.8%         | 
|TERMINAL (d)       |     2/37 (5%)    3/43 (7%)    1/34 (3%)    4/40 (10%)  |1/35 (3%)    3/34 (9%)    3/41 (7%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      676          726 (T)     |729 (T)      674          729 (T)      717          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.300      P=0.569      P=0.658      P=0.373     |P=0.511      P=0.105      P=0.363      P=0.281      | 
|POLY 3             |     P=0.282      P=0.497      P=0.664      P=0.326     |P=0.548      P=0.100      P=0.309      P=0.306      | 
|POLY 1.5           |     P=0.286      P=0.496      P=0.675      P=0.330     |P=0.544      P=0.099      P=0.303      P=0.304      | 
|POLY 6             |     P=0.277      P=0.502      P=0.655      P=0.323     |P=0.551      P=0.102      P=0.321      P=0.309      | 
|LOGISTIC REGRESSION|     P=0.275      P=0.569      P=0.661      P=0.373     |P=0.552      P=0.100      P=0.363      P=0.308      | 
|COCH-ARM / FISHERS |     P=0.290      P=0.500      P=0.691N     P=0.339     |P=0.546      P=0.102      P=0.309      P=0.309      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.21      0/46.90      0/43.35      0/46.04     |0/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     725          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.258N     P=0.217N     P=0.269N     P=0.233N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.249N     P=0.239N     P=0.257N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.249N     P=0.239N     P=0.249N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.251N     P=0.236N     P=0.264N     P=0.244N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.260N     P=0.224N     P=0.268N     P=0.240N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.253N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/47.21      4/46.90      2/43.35      2/46.42     |0/44.21      0/43.59      1/44.71      3/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         8.5%         4.6%         4.3%        |0.0%         0.0%         2.2%         6.8%         | 
|TERMINAL (d)       |     1/37 (3%)    4/43 (9%)    2/34 (6%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    1/41 (2%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      726 (T)      618         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.556N     P=0.227      P=0.470      P=0.513     |P=0.015 *    (e)          P=0.532      P=0.105      | 
|POLY 3             |     P=0.570N     P=0.177      P=0.470      P=0.494     |P=0.022 *    (e)          P=0.502      P=0.119      | 
|POLY 1.5           |     P=0.569N     P=0.177      P=0.481      P=0.496     |P=0.022 *    (e)          P=0.499      P=0.118      | 
|POLY 6             |     P=0.571N     P=0.180      P=0.460      P=0.494     |P=0.022 *    (e)          P=0.509      P=0.120      | 
|LOGISTIC REGRESSION|     P=0.575N     P=0.227      P=0.470      P=0.520     |(e)          (e)          P=0.532      P=0.105      | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.181      P=0.500      P=0.500     |P=0.022 *    (e)          P=0.500      P=0.121      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     39/50 (78%)  42/50 (84%)  37/50 (74%)  40/50 (80%) |24/50 (48%)  18/50 (36%)  23/50 (46%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     39/48.50     42/47.78     37/46.82     40/47.96    |24/47.98     18/46.50     23/47.01     20/45.91     | 
|POLY-3 PERCENT (g) |     80.4%        87.9%        79.0%        83.4%       |50.0%        38.7%        48.9%        43.6%        | 
|TERMINAL (d)       |     33/37 (89%)  40/43 (93%)  29/34 (85%)  35/40 (88%) |17/35 (49%)  11/34 (32%)  19/41 (46%)  13/32 (41%)  | 
|FIRST INCIDENCE    |     580          554          439          554         |329          444          338          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.486N     P=0.348N     P=0.463      P=0.461N    |P=0.513N     P=0.207N     P=0.308N     P=0.379N     | 
|POLY 3             |     P=0.559      P=0.224      P=0.536N     P=0.451     |P=0.454N     P=0.183N     P=0.539N     P=0.337N     | 
|POLY 1.5           |     P=0.562      P=0.244      P=0.486N     P=0.465     |P=0.441N     P=0.182N     P=0.543N     P=0.326N     | 
|POLY 6             |     P=0.559      P=0.218      P=0.586N     P=0.446     |P=0.463N     P=0.176N     P=0.518N     P=0.338N     | 
|LOGISTIC REGRESSION|     P=0.509      P=0.239      P=0.568      P=0.391     |P=0.399N     P=0.142N     P=0.494N     P=0.273N     | 
|COCH-ARM / FISHERS |     P=0.554N     P=0.306      P=0.408N     P=0.500     |P=0.399N     P=0.156N     P=0.500N     P=0.273N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Glomerulus                                                                                                               | 
|     Amyloid Deposition                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      0/46.04     |0/44.21      2/45.53      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          221          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.396N     P=0.238      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.387N     P=0.244      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.389N     P=0.242      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.386N     P=0.246      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.201N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.392N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Glomerulus                                                                                                               | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.21      2/46.90      0/43.35      2/46.04     |0/44.21      0/43.59      0/44.71      1/44.36      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         4.3%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/37 (0%)    2/43 (5%)    0/34 (0%)    2/40 (5%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          726 (T)     |---          ---          ---          712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292      P=0.272      (e)          P=0.256     |P=0.220      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.278      P=0.236      (e)          P=0.232     |P=0.223      (e)          (e)          P=0.501      | 
|POLY 1.5           |     P=0.280      P=0.236      (e)          P=0.234     |P=0.222      (e)          (e)          P=0.499      | 
|POLY 6             |     P=0.277      P=0.238      (e)          P=0.230     |P=0.224      (e)          (e)          P=0.503      | 
|LOGISTIC REGRESSION|     (e)          P=0.272      (e)          P=0.256     |P=0.221      (e)          (e)          P=0.501      | 
|COCH-ARM / FISHERS |     P=0.283      P=0.247      (e)          P=0.247     |P=0.221      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.33      2/46.90      0/43.35      4/46.04     |0/44.21      0/43.59      1/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     8.5%         4.3%         0.0%         8.7%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     3/37 (8%)    2/43 (5%)    0/34 (0%)    4/40 (10%)  |0/35 (0%)    0/34 (0%)    1/41 (2%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     694          726 (T)      ---          726 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.403      P=0.279N     P=0.078N     P=0.609N    |P=0.799N     (e)          P=0.532      (e)          | 
|POLY 3             |     P=0.390      P=0.342N     P=0.072N     P=0.628     |P=0.778N     (e)          P=0.502      (e)          | 
|POLY 1.5           |     P=0.393      P=0.342N     P=0.068N     P=0.633     |P=0.779N     (e)          P=0.499      (e)          | 
|POLY 6             |     P=0.386      P=0.338N     P=0.077N     P=0.623     |P=0.777N     (e)          P=0.509      (e)          | 
|LOGISTIC REGRESSION|     P=0.378      P=0.333N     P=0.078N     P=0.627     |(e)          (e)          P=0.532      (e)          | 
|COCH-ARM / FISHERS |     P=0.395      P=0.339N     P=0.059N     P=0.643N    |P=0.779N     (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.90      1/44.04      2/46.39     |0/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.3%         4.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      487          628         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202      P=0.530      P=0.488      P=0.243     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.194      P=0.499      P=0.486      P=0.233     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.196      P=0.498      P=0.491      P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.193      P=0.501      P=0.481      P=0.233     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.199      P=0.530      P=0.922      P=0.258     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.197      P=0.500      P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   3/50 (6%)    2/50 (4%)   |4/50 (8%)    0/50 (0%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/47.21      6/46.90      3/43.45      2/47.40     |4/44.84      0/43.59      3/44.71      3/44.29      | 
|POLY-3 PERCENT (g) |     4.2%         12.8%        6.9%         4.2%        |8.9%         0.0%         6.7%         6.8%         | 
|TERMINAL (d)       |     2/37 (5%)    6/43 (14%)   2/34 (6%)    0/40 (0%)   |2/35 (6%)    0/34 (0%)    3/41 (7%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      699          399         |619          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.298N     P=0.186      P=0.460      P=0.680N    |P=0.447      P=0.067N     P=0.432N     P=0.530N     | 
|POLY 3             |     P=0.294N     P=0.131      P=0.462      P=0.692N    |P=0.488      P=0.064N     P=0.502N     P=0.507N     | 
|POLY 1.5           |     P=0.296N     P=0.131      P=0.476      P=0.693N    |P=0.486      P=0.063N     P=0.507N     P=0.507N     | 
|POLY 6             |     P=0.292N     P=0.134      P=0.450      P=0.691N    |P=0.488      P=0.064N     P=0.490N     P=0.508N     | 
|LOGISTIC REGRESSION|     P=0.292N     P=0.186      P=0.442      P=0.548N    |P=0.486      P=0.062N     P=0.500N     P=0.501N     | 
|COCH-ARM / FISHERS |     P=0.300N     P=0.134      P=0.500      P=0.691N    |P=0.483      P=0.059N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  23/50 (46%)  14/50 (28%)  11/50 (22%) |4/50 (8%)    3/50 (6%)    3/50 (6%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     19/47.57     23/46.90     14/43.35     11/46.34    |4/44.21      3/43.59      3/44.71      5/45.20      | 
|POLY-3 PERCENT (g) |     39.9%        49.0%        32.3%        23.7%       |9.1%         6.9%         6.7%         11.1%        | 
|TERMINAL (d)       |     18/37 (49%)  23/43 (54%)  14/34 (41%)  10/40 (25%) |4/35 (11%)   3/34 (9%)    3/41 (7%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     624          726 (T)      726 (T)      644         |729 (T)      729 (T)      729 (T)      527          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.009N**   P=0.505      P=0.277N     P=0.036N*   |P=0.290      P=0.516N     P=0.414N     P=0.460      | 
|POLY 3             |     P=0.014N*    P=0.246      P=0.294N     P=0.069N    |P=0.357      P=0.508N     P=0.494N     P=0.514      | 
|POLY 1.5           |     P=0.014N*    P=0.251      P=0.255N     P=0.067N    |P=0.349      P=0.509N     P=0.503N     P=0.504      | 
|POLY 6             |     P=0.014N*    P=0.250      P=0.338N     P=0.071N    |P=0.365      P=0.505N     P=0.476N     P=0.526      | 
|LOGISTIC REGRESSION|     P=0.018N*    P=0.301      P=0.345N     P=0.074N    |P=0.343      P=0.516N     P=0.414N     P=0.498      | 
|COCH-ARM / FISHERS |     P=0.015N*    P=0.272      P=0.198N     P=0.063N    |P=0.340      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   20/50 (40%)  31/50 (62%)  30/50 (60%) |16/50 (32%)  22/50 (44%)  28/50 (56%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     9/47.21      20/47.45     31/45.55     30/46.94    |16/44.60     22/44.24     28/46.06     32/46.17     | 
|POLY-3 PERCENT (g) |     19.1%        42.2%        68.1%        63.9%       |35.9%        49.7%        60.8%        69.3%        | 
|TERMINAL (d)       |     9/37 (24%)   19/43 (44%)  25/34 (74%)  27/40 (68%) |15/35 (43%)  19/34 (56%)  24/41 (59%)  21/32 (66%)  | 
|FIRST INCIDENCE    |     726 (T)      554          439          618         |619          665          573          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.036 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.123      P=0.055      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P=0.002 **   P=0.130      P=0.012 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.131      P=0.010 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P=0.002 **   P=0.135      P=0.020 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P=0.002 **   P=0.133      P=0.013 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P=0.002 **   P=0.151      P=0.013 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    1/50 (2%)    2/50 (4%)   |4/50 (8%)    3/50 (6%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     3/47.21      4/46.90      1/43.35      2/46.42     |4/45.41      3/43.84      3/45.63      4/45.22      | 
|POLY-3 PERCENT (g) |     6.4%         8.5%         2.3%         4.3%        |8.8%         6.8%         6.6%         8.9%         | 
|TERMINAL (d)       |     3/37 (8%)    4/43 (9%)    1/34 (3%)    1/40 (3%)   |2/35 (6%)    2/34 (6%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      726 (T)      618         |329          665          444          595          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.339N     P=0.582      P=0.335N     P=0.476N    |P=0.493      P=0.499N     P=0.454N     P=0.618      | 
|POLY 3             |     P=0.347N     P=0.496      P=0.337N     P=0.508N    |P=0.521      P=0.519N     P=0.497N     P=0.641      | 
|POLY 1.5           |     P=0.347N     P=0.496      P=0.325N     P=0.505N    |P=0.516      P=0.517N     P=0.506N     P=0.636      | 
|POLY 6             |     P=0.347N     P=0.502      P=0.348N     P=0.508N    |P=0.528      P=0.518N     P=0.480N     P=0.638N     | 
|LOGISTIC REGRESSION|     P=0.356N     P=0.582      P=0.335N     P=0.498N    |P=0.522      P=0.470N     P=0.438N     P=0.612N     | 
|COCH-ARM / FISHERS |     P=0.345N     P=0.500      P=0.309N     P=0.500N    |P=0.514      P=0.500N     P=0.500N     P=0.643N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      1/43.35      0/46.04     |0/44.21      2/43.84      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.3%         0.0%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    1/34 (3%)    0/40 (0%)   |0/35 (0%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     725          ---          726 (T)      ---         |---          665          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.463N     P=0.481N     P=0.736      P=0.495N    |P=0.399N     P=0.250      (e)          (e)          | 
|POLY 3             |     P=0.467N     P=0.501N     P=0.741      P=0.505N    |P=0.394N     P=0.235      (e)          (e)          | 
|POLY 1.5           |     P=0.465N     P=0.502N     P=0.748      P=0.503N    |P=0.394N     P=0.234      (e)          (e)          | 
|POLY 6             |     P=0.470N     P=0.499N     P=0.734      P=0.506N    |P=0.392N     P=0.237      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.470N     P=0.489N     P=0.731      P=0.503N    |P=0.392N     P=0.235      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.464N     P=0.500N     P=0.753N     P=0.500N    |P=0.392N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    2/50 (4%)    3/50 (6%)   |26/50 (52%)  30/50 (60%)  36/50 (72%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     3/47.21      2/46.90      2/43.35      3/46.42     |26/45.27     30/45.03     36/45.97     20/44.90     | 
|POLY-3 PERCENT (g) |     6.4%         4.3%         4.6%         6.5%        |57.4%        66.6%        78.3%        44.6%        | 
|TERMINAL (d)       |     3/37 (8%)    2/43 (5%)    2/34 (6%)    2/40 (5%)   |23/35 (66%)  25/34 (74%)  33/41 (81%)  16/32 (50%)  | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      726 (T)      618         |619          594          338          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.526      P=0.431N     P=0.539N     P=0.635N    |P=0.074N     P=0.223      P=0.166      P=0.252N     | 
|POLY 3             |     P=0.512      P=0.503N     P=0.539N     P=0.654     |P=0.021N*    P=0.241      P=0.022 *    P=0.150N     | 
|POLY 1.5           |     P=0.514      P=0.504N     P=0.524N     P=0.656     |P=0.025N*    P=0.238      P=0.021 *    P=0.159N     | 
|POLY 6             |     P=0.509      P=0.498N     P=0.552N     P=0.654     |P=0.019N*    P=0.255      P=0.028 *    P=0.141N     | 
|LOGISTIC REGRESSION|     P=0.505      P=0.431N     P=0.539N     P=0.660     |P=0.022N*    P=0.244      P=0.027 *    P=0.129N     | 
|COCH-ARM / FISHERS |     P=0.517      P=0.500N     P=0.500N     P=0.661N    |P=0.033N*    P=0.273      P=0.032 *    P=0.158N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   14/50 (28%)  10/50 (20%)  11/50 (22%) |14/50 (28%)  27/50 (54%)  22/50 (44%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     9/47.35      14/46.90     10/43.35     11/46.04    |14/45.33     27/44.25     22/45.61     15/44.72     | 
|POLY-3 PERCENT (g) |     19.0%        29.9%        23.1%        23.9%       |30.9%        61.0%        48.2%        33.5%        | 
|TERMINAL (d)       |     8/37 (22%)   14/43 (33%)  10/34 (29%)  11/40 (28%) |12/35 (34%)  24/34 (71%)  21/41 (51%)  14/32 (44%)  | 
|FIRST INCIDENCE    |     688          726 (T)      726 (T)      726 (T)     |469          665          338          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.534N     P=0.286      P=0.415      P=0.470     |P=0.249N     P=0.004 **   P=0.171      P=0.392      | 
|POLY 3             |     P=0.537      P=0.161      P=0.415      P=0.374     |P=0.155N     P=0.003 **   P=0.066      P=0.482      | 
|POLY 1.5           |     P=0.547      P=0.163      P=0.447      P=0.384     |P=0.161N     P=0.003 **   P=0.063      P=0.481      | 
|POLY 6             |     P=0.523      P=0.165      P=0.383      P=0.364     |P=0.151N     P=0.002 **   P=0.076      P=0.486      | 
|LOGISTIC REGRESSION|     P=0.524      P=0.195      P=0.366      P=0.375     |P=0.148N     P=0.005 **   P=0.070      P=0.504      | 
|COCH-ARM / FISHERS |     P=0.557N     P=0.171      P=0.500      P=0.402     |P=0.163N     P=0.007 **   P=0.072      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  15/50 (30%)  8/50 (16%)  |5/50 (10%)   8/50 (16%)   14/50 (28%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     13/47.21     11/46.90     15/43.85     8/46.34     |5/44.60      8/43.59      14/44.71     11/44.64     | 
|POLY-3 PERCENT (g) |     27.5%        23.5%        34.2%        17.3%       |11.2%        18.4%        31.3%        24.6%        | 
|TERMINAL (d)       |     13/37 (35%)  11/43 (26%)  13/34 (38%)  7/40 (18%)  |4/35 (11%)   8/34 (24%)   14/41 (34%)  8/32 (25%)   | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      614          644         |619          729 (T)      729 (T)      685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.133N     P=0.248N     P=0.304      P=0.117N    |P=0.088      P=0.256      P=0.044 *    P=0.072      | 
|POLY 3             |     P=0.152N     P=0.414N     P=0.322      P=0.172N    |P=0.139      P=0.259      P=0.017 *    P=0.082      | 
|POLY 1.5           |     P=0.150N     P=0.416N     P=0.354      P=0.170N    |P=0.135      P=0.262      P=0.017 *    P=0.081      | 
|POLY 6             |     P=0.155N     P=0.402N     P=0.296      P=0.172N    |P=0.144      P=0.258      P=0.020 *    P=0.084      | 
|LOGISTIC REGRESSION|     P=0.169N     P=0.248N     P=0.259      P=0.180N    |P=0.140      P=0.269      P=0.026 *    P=0.087      | 
|COCH-ARM / FISHERS |     P=0.147N     P=0.408N     P=0.412      P=0.163N    |P=0.139      P=0.277      P=0.020 *    P=0.086      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    7/50 (14%)   6/50 (12%)  |0/50 (0%)    5/50 (10%)   1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     4/47.72      3/47.22      7/44.85      6/47.34     |0/44.21      5/44.33      1/44.86      3/45.04      | 
|POLY-3 PERCENT (g) |     8.4%         6.4%         15.6%        12.7%       |0.0%         11.3%        2.2%         6.7%         | 
|TERMINAL (d)       |     2/37 (5%)    2/43 (5%)    1/34 (3%)    3/40 (8%)   |0/35 (0%)    2/34 (6%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     628          637          517          399         |---          610          692          595          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.261      P=0.458N     P=0.211      P=0.386     |P=0.391      P=0.036 *    P=0.525      P=0.124      | 
|POLY 3             |     P=0.254      P=0.506N     P=0.227      P=0.365     |P=0.404      P=0.031 *    P=0.503      P=0.122      | 
|POLY 1.5           |     P=0.256      P=0.506N     P=0.239      P=0.367     |P=0.397      P=0.030 *    P=0.499      P=0.119      | 
|POLY 6             |     P=0.249      P=0.502N     P=0.218      P=0.363     |P=0.414      P=0.032 *    P=0.510      P=0.125      | 
|LOGISTIC REGRESSION|     P=0.269      P=0.482N     P=0.344      P=0.457     |P=0.397      P=0.033 *    P=0.500      P=0.125      | 
|COCH-ARM / FISHERS |     P=0.256      P=0.500N     P=0.262      P=0.370     |P=0.397      P=0.028 *    P=0.500      P=0.121      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    3/50 (6%)    5/50 (10%)  |8/50 (16%)   1/50 (2%)    6/50 (12%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/47.35      1/46.90      3/43.35      5/46.70     |8/45.47      1/43.59      6/44.71      6/44.57      | 
|POLY-3 PERCENT (g) |     4.2%         2.1%         6.9%         10.7%       |17.6%        2.3%         13.4%        13.5%        | 
|TERMINAL (d)       |     1/37 (3%)    1/43 (2%)    3/34 (9%)    3/40 (8%)   |5/35 (14%)   1/34 (3%)    6/41 (15%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     688          726 (T)      726 (T)      628         |469          729 (T)      729 (T)      653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.080      P=0.463N     P=0.458      P=0.231     |P=0.398      P=0.021N*    P=0.293N     P=0.431N     | 
|POLY 3             |     P=0.073      P=0.503N     P=0.460      P=0.211     |P=0.460      P=0.018N*    P=0.399N     P=0.402N     | 
|POLY 1.5           |     P=0.074      P=0.503N     P=0.475      P=0.212     |P=0.457      P=0.018N*    P=0.403N     P=0.401N     | 
|POLY 6             |     P=0.072      P=0.501N     P=0.445      P=0.211     |P=0.463      P=0.019N*    P=0.385N     P=0.402N     | 
|LOGISTIC REGRESSION|     P=0.074      P=0.502N     P=0.446      P=0.230     |P=0.455      P=0.018N*    P=0.389N     P=0.388N     | 
|COCH-ARM / FISHERS |     P=0.075      P=0.500N     P=0.500      P=0.218     |P=0.453      P=0.015N*    P=0.387N     P=0.387N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      0/43.35      0/46.04     |2/44.91      0/43.59      3/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |4.5%         0.0%         6.7%         2.3%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    3/41 (7%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          ---          ---         |595          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.485N     P=0.470N     P=0.517N     P=0.484N    |P=0.585N     P=0.239N     P=0.546      P=0.504N     | 
|POLY 3             |     P=0.485N     P=0.501N     P=0.517N     P=0.505N    |P=0.561N     P=0.244N     P=0.498      P=0.505N     | 
|POLY 1.5           |     P=0.485N     P=0.502N     P=0.511N     P=0.503N    |P=0.562N     P=0.243N     P=0.494      P=0.505N     | 
|POLY 6             |     P=0.485N     P=0.499N     P=0.523N     P=0.506N    |P=0.560N     P=0.245N     P=0.508      P=0.506N     | 
|LOGISTIC REGRESSION|     P=0.485N     (e)          (e)          (e)         |P=0.563N     P=0.212N     P=0.500      P=0.490N     | 
|COCH-ARM / FISHERS |     P=0.488N     P=0.500N     P=0.500N     P=0.500N    |P=0.563N     P=0.247N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.25      0/46.90      0/43.35      0/46.04     |1/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         0.0%         0.0%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |1/35 (3%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     714          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.258N     P=0.218N     P=0.270N     P=0.234N    |P=0.515N     P=0.506N     P=0.468N     P=0.518N     | 
|POLY 3             |     P=0.249N     P=0.239N     P=0.257N     P=0.243N    |P=0.499N     P=0.503N     P=0.498N     P=0.500N     | 
|POLY 1.5           |     P=0.249N     P=0.239N     P=0.250N     P=0.241N    |P=0.498N     P=0.503N     P=0.501N     P=0.501N     | 
|POLY 6             |     P=0.251N     P=0.237N     P=0.264N     P=0.245N    |P=0.501N     P=0.502N     P=0.491N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.260N     P=0.236N     P=0.265N     P=0.244N    |P=0.515N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.253N     P=0.247N     P=0.247N     P=0.247N    |P=0.500N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      0/46.04     |0/44.21      2/44.69      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          221          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.389N     P=0.237      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.390N     P=0.239      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.392N     P=0.238      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.389N     P=0.242      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.334N     P=0.353      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.392N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/47.21      2/47.09      1/43.35      2/46.39     |0/44.21      0/43.59      1/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     4.2%         4.3%         2.3%         4.3%        |0.0%         0.0%         2.2%         2.3%         | 
|TERMINAL (d)       |     2/37 (5%)    1/43 (2%)    1/34 (3%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      676          726 (T)      628         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.618      P=0.652N     P=0.530N     P=0.676N    |P=0.299      (e)          P=0.532      P=0.482      | 
|POLY 3             |     P=0.612      P=0.693      P=0.530N     P=0.687     |P=0.328      (e)          P=0.502      P=0.500      | 
|POLY 1.5           |     P=0.614      P=0.691      P=0.519N     P=0.689     |P=0.326      (e)          P=0.499      P=0.499      | 
|POLY 6             |     P=0.610      P=0.690N     P=0.540N     P=0.687     |P=0.331      (e)          P=0.509      P=0.502      | 
|LOGISTIC REGRESSION|     P=0.615      P=0.693      P=0.530N     P=0.691N    |(e)          (e)          P=0.532      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.618      P=0.691N     P=0.500N     P=0.691N    |P=0.325      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/49 (0%)    0/48 (0%)   |1/49 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.25      0/46.57      0/42.35      0/44.04     |1/43.21      0/43.59      2/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/33 (0%)    0/38 (0%)   |1/34 (3%)    0/34 (0%)    2/41 (5%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.460N     P=0.500N     P=0.565      P=0.512N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.434N     P=0.498N     P=0.512      P=0.495N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.436N     P=0.499N     P=0.506      P=0.497N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.432N     P=0.497N     P=0.524      P=0.493N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.460N     (e)          P=0.565      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.438N     P=0.495N     P=0.508      P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     0/1 (0%)     0/1 (0%)    |1/6 (17%)    1/7 (14%)    0/4 (0%)     2/6 (33%)    | 
|POLY-3 RATE (b)    |     0/0.35       0/0.00       0/0.86       0/0.47      |1/5.68       1/5.97       0/3.28       2/5.47       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |17.6%        16.8%        0.0%         36.6%        | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |1/5 (20%)    0/2 (0%)     0/2 (0%)     2/5 (40%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      665          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.426      P=0.681      P=0.682N     P=0.500      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.314      P=0.754N     P=0.606N     P=0.486      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.312      P=0.740N     P=0.594N     P=0.491      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.323      P=0.758      P=0.623N     P=0.483      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.338      P=0.773N     (e)          P=0.500      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.303      P=0.731N     P=0.600N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/3 (100%)   3/3 (100%)   4/5 (80%)    5/7 (71%)   |10/11 (91%)  6/6 (100%)   3/4 (75%)    9/9 (100%)   | 
|POLY-3 RATE (b)    |     3/3.00       3/3.00       4/5.00       5/6.47      |10/11.00     6/6.00       3/3.49       9/9.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       80.0%        77.2%       |90.9%        100.0%       86.1%        100.0%       | 
|TERMINAL (d)       |     3/3 (100%)   3/3 (100%)   4/5 (80%)    4/5 (80%)   |8/9 (89%)    4/4 (100%)   3/3 (100%)   8/8 (100%)   | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      726 (T)      399         |329          610          729 (T)      617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.591      (e)          P=0.602N     P=0.705     |P=0.583N     P=0.554      P=0.378N     P=0.681N     | 
|POLY 3             |     P=0.331N     (e)          P=0.599N     P=0.526N    |P=0.465      P=0.619      P=0.769N     P=0.540      | 
|POLY 1.5           |     P=0.289N     (e)          P=0.599N     P=0.483N    |P=0.460      P=0.619      P=0.664N     P=0.540      | 
|POLY 6             |     P=0.392N     (e)          P=0.599N     P=0.585N    |P=0.473      P=0.619      P=0.833      P=0.540      | 
|LOGISTIC REGRESSION|     P=0.283N     (e)          P=0.602N     P=0.487N    |P=0.508      (e)          P=0.513N     (e)          | 
|COCH-ARM / FISHERS |     P=0.228N     (e)          P=0.625N     P=0.467N    |P=0.453      P=0.647      P=0.476N     P=0.550      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.25      0/46.90      1/43.55      0/46.04     |0/44.21      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     716          ---          673          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.280N     P=0.216N     P=0.542N     P=0.231N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.275N     P=0.239N     P=0.528N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.274N     P=0.239N     P=0.518N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.278N     P=0.237N     P=0.538N     P=0.245N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.275N     P=0.235N     P=0.518N     P=0.244N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.274N     P=0.247N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/31 (100%) 26/26 (100%) 35/35 (100%) 30/30 (100%)|26/26 (100%) 26/26 (100%) 31/31 (100%) 31/31 (100%) | 
|POLY-3 RATE (b)    |     31/31.00     26/26.00     35/35.00     30/30.00    |26/26.00     26/26.00     31/31.00     31/31.00     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |100.0%       100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     25/25 (100%) 26/26 (100%) 28/28 (100%) 27/27 (100%)|23/23 (100%) 22/22 (100%) 30/30 (100%) 25/25 (100%) | 
|FIRST INCIDENCE    |     580          726 (T)      439          566         |532          594          674          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/44.49      0/43.59      2/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |                                                        |4.5%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    0/34 (0%)    2/41 (5%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |653          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.293N     P=0.235N     P=0.644N     P=0.244N     | 
|POLY 3             |                                                        |P=0.276N     P=0.242N     P=0.692N     P=0.238N     | 
|POLY 1.5           |                                                        |P=0.278N     P=0.241N     P=0.691      P=0.239N     | 
|POLY 6             |                                                        |P=0.276N     P=0.241N     P=0.683N     P=0.237N     | 
|LOGISTIC REGRESSION|                                                        |P=0.279N     P=0.238N     P=0.693N     P=0.238N     | 
|COCH-ARM / FISHERS |                                                        |P=0.280N     P=0.247N     P=0.691N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |27/50 (54%)  22/50 (44%)  21/50 (42%)  25/50 (50%)  | 
|POLY-3 RATE (b)    |                                                        |27/45.63     22/45.88     21/47.21     25/45.75     | 
|POLY-3 PERCENT (g) |                                                        |59.2%        48.0%        44.5%        54.7%        | 
|TERMINAL (d)       |                                                        |23/35 (66%)  17/34 (50%)  17/41 (42%)  17/32 (53%)  | 
|FIRST INCIDENCE    |                                                        |532          239          62           567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.383      P=0.240N     P=0.055N     P=0.542N     | 
|POLY 3             |                                                        |P=0.509      P=0.188N     P=0.109N     P=0.409N     | 
|POLY 1.5           |                                                        |P=0.499      P=0.201N     P=0.130N     P=0.428N     | 
|POLY 6             |                                                        |P=0.526      P=0.174N     P=0.083N     P=0.380N     | 
|LOGISTIC REGRESSION|                                                        |P=0.515      P=0.229N     P=0.162N     P=0.408N     | 
|COCH-ARM / FISHERS |                                                        |P=0.514      P=0.212N     P=0.158N     P=0.421N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.21      1/44.25      3/45.98      1/44.29      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.3%         6.5%         2.3%         | 
|TERMINAL (d)       |                                                        |0/35 (0%)    0/34 (0%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |---          510          444          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.533      P=0.496      P=0.129      P=0.482      | 
|POLY 3             |                                                        |P=0.548      P=0.500      P=0.126      P=0.500      | 
|POLY 1.5           |                                                        |P=0.545      P=0.499      P=0.121      P=0.499      | 
|POLY 6             |                                                        |P=0.551      P=0.503      P=0.134      P=0.502      | 
|LOGISTIC REGRESSION|                                                        |P=0.566      P=0.591      P=0.145      P=0.482      | 
|COCH-ARM / FISHERS |                                                        |P=0.546      P=0.500      P=0.121      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.90      0/43.35      0/46.04     |1/44.21      3/43.59      1/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |2.3%         6.9%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    0/40 (0%)   |1/35 (3%)    3/34 (9%)    1/41 (2%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.585N     P=0.530      (e)          (e)         |P=0.189N     P=0.294      P=0.726N     P=0.518N     | 
|POLY 3             |     P=0.590N     P=0.499      (e)          (e)         |P=0.176N     P=0.300      P=0.758N     P=0.500N     | 
|POLY 1.5           |     P=0.590N     P=0.498      (e)          (e)         |P=0.178N     P=0.300      P=0.759      P=0.501N     | 
|POLY 6             |     P=0.588N     P=0.501      (e)          (e)         |P=0.175N     P=0.302      P=0.751N     P=0.498N     | 
|LOGISTIC REGRESSION|     (e)          P=0.530      (e)          (e)         |P=0.189N     P=0.294      P=0.726N     (e)          | 
|COCH-ARM / FISHERS |     P=0.590N     P=0.500      (e)          (e)         |P=0.177N     P=0.309      P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/43.35      1/46.04     |1/44.21      2/43.59      1/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |2.3%         4.6%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    1/40 (3%)   |1/35 (3%)    2/34 (6%)    1/41 (2%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          726 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.224      (e)          (e)          P=0.516     |P=0.253N     P=0.490      P=0.726N     P=0.518N     | 
|POLY 3             |     P=0.215      (e)          (e)          P=0.495     |P=0.239N     P=0.495      P=0.758N     P=0.500N     | 
|POLY 1.5           |     P=0.216      (e)          (e)          P=0.497     |P=0.240N     P=0.494      P=0.759      P=0.501N     | 
|POLY 6             |     P=0.213      (e)          (e)          P=0.494     |P=0.238N     P=0.497      P=0.751N     P=0.498N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.516     |P=0.253N     P=0.490      P=0.726N     (e)          | 
|COCH-ARM / FISHERS |     P=0.218      (e)          (e)          P=0.500     |P=0.238N     P=0.500      P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    0/49 (0%)    1/50 (2%)   |11/50 (22%)  3/50 (6%)    9/50 (18%)   12/50 (24%)  | 
|POLY-3 RATE (b)    |     1/47.21      2/46.22      0/42.35      1/46.04     |11/44.87     3/43.59      9/44.92      12/44.57     | 
|POLY-3 PERCENT (g) |     2.1%         4.3%         0.0%         2.2%        |24.5%        6.9%         20.0%        26.9%        | 
|TERMINAL (d)       |     1/37 (3%)    2/43 (5%)    0/33 (0%)    1/40 (3%)   |9/35 (26%)   3/34 (9%)    8/41 (20%)   11/32 (34%)  | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          726 (T)     |617          729 (T)      674          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.557N     P=0.552      P=0.523N     P=0.744N    |P=0.080      P=0.024N*    P=0.273N     P=0.417      | 
|POLY 3             |     P=0.564N     P=0.493      P=0.522N     P=0.755     |P=0.126      P=0.021N*    P=0.399N     P=0.493      | 
|POLY 1.5           |     P=0.563N     P=0.491      P=0.515N     P=0.757     |P=0.125      P=0.022N*    P=0.411N     P=0.489      | 
|POLY 6             |     P=0.564N     P=0.498      P=0.528N     P=0.754     |P=0.126      P=0.021N*    P=0.374N     P=0.495      | 
|LOGISTIC REGRESSION|     P=0.557N     P=0.552      (e)          P=0.744N    |P=0.128      P=0.022N*    P=0.375N     P=0.511      | 
|COCH-ARM / FISHERS |     P=0.562N     P=0.492      P=0.505N     P=0.753N    |P=0.126      P=0.020N*    P=0.402N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.22      0/42.35      3/46.39     |0/44.21      1/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         6.5%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    0/33 (0%)    2/40 (5%)   |0/35 (0%)    1/34 (3%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          ---          628         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.059      P=0.470N     P=0.523N     P=0.324     |P=0.619N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.054      P=0.504N     P=0.522N     P=0.299     |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 1.5           |     P=0.054      P=0.505N     P=0.515N     P=0.301     |P=0.603N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.053      P=0.501N     P=0.528N     P=0.299     |P=0.604N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.055      (e)          (e)          P=0.309     |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.055      P=0.505N     P=0.505N     P=0.309     |P=0.601N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  14/50 (28%)  11/50 (22%)  15/50 (30%) |                                                    | 
|POLY-3 RATE (b)    |     10/47.33     14/47.29     11/44.90     15/46.95    |                                                    | 
|POLY-3 PERCENT (g) |     21.1%        29.6%        24.5%        32.0%       |                                                    | 
|TERMINAL (d)       |     9/37 (24%)   13/43 (30%)  8/34 (24%)   13/40 (33%) |                                                    | 
|FIRST INCIDENCE    |     694          615          443          554         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.377      P=0.416      P=0.232     |                                                    | 
|POLY 3             |     P=0.213      P=0.239      P=0.446      P=0.169     |                                                    | 
|POLY 1.5           |     P=0.217      P=0.236      P=0.466      P=0.171     |                                                    | 
|POLY 6             |     P=0.211      P=0.250      P=0.425      P=0.168     |                                                    | 
|LOGISTIC REGRESSION|     P=0.213      P=0.241      P=0.487      P=0.160     |                                                    | 
|COCH-ARM / FISHERS |     P=0.221      P=0.241      P=0.500      P=0.178     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     0/47.21      1/46.90      0/43.35      3/46.04     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         6.5%        |                                                    | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    3/40 (8%)   |                                                    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          726 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    P=0.530      (e)          P=0.135     |                                                    | 
|POLY 3             |     P=0.039 *    P=0.499      (e)          P=0.114     |                                                    | 
|POLY 1.5           |     P=0.039 *    P=0.498      (e)          P=0.116     |                                                    | 
|POLY 6             |     P=0.038 *    P=0.501      (e)          P=0.113     |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.530      (e)          P=0.135     |                                                    | 
|COCH-ARM / FISHERS |     P=0.041 *    P=0.500      (e)          P=0.121     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/47.21      0/46.90      0/43.35      2/46.04     |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         4.3%        |                                                    | 
|TERMINAL (d)       |     1/37 (3%)    0/43 (0%)    0/34 (0%)    2/40 (5%)   |                                                    | 
|FIRST INCIDENCE    |     726 (T)      ---          ---          726 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.195      P=0.470N     P=0.517N     P=0.527     |                                                    | 
|POLY 3             |     P=0.185      P=0.501N     P=0.517N     P=0.491     |                                                    | 
|POLY 1.5           |     P=0.186      P=0.502N     P=0.511N     P=0.494     |                                                    | 
|POLY 6             |     P=0.182      P=0.499N     P=0.523N     P=0.489     |                                                    | 
|LOGISTIC REGRESSION|     P=0.195      (e)          (e)          P=0.527     |                                                    | 
|COCH-ARM / FISHERS |     P=0.187      P=0.500N     P=0.500N     P=0.500     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/47.21      2/46.90      2/43.35      0/46.04     |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         4.3%         4.6%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/37 (3%)    2/43 (5%)    2/34 (6%)    0/40 (0%)   |                                                    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      726 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241N     P=0.552      P=0.470      P=0.484N    |                                                    | 
|POLY 3             |     P=0.252N     P=0.498      P=0.470      P=0.505N    |                                                    | 
|POLY 1.5           |     P=0.249N     P=0.497      P=0.481      P=0.503N    |                                                    | 
|POLY 6             |     P=0.254N     P=0.501      P=0.460      P=0.506N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.241N     P=0.552      P=0.470      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.244N     P=0.500      P=0.500      P=0.500N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Epidermis                                                                                            | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/47.21      0/46.90      0/43.35      0/46.04     |3/45.45      0/43.59      0/44.71      0/44.29      | 
|POLY-3 PERCENT (g) |     6.4%         0.0%         0.0%         0.0%        |6.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/37 (5%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     725          ---          ---          ---         |469          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.145N     P=0.101N     P=0.142N     P=0.113N    |P=0.147N     P=0.118N     P=0.115N     P=0.118N     | 
|POLY 3             |     P=0.137N     P=0.120N     P=0.135N     P=0.123N    |P=0.140N     P=0.126N     P=0.122N     P=0.123N     | 
|POLY 1.5           |     P=0.137N     P=0.120N     P=0.129N     P=0.122N    |P=0.141N     P=0.125N     P=0.123N     P=0.123N     | 
|POLY 6             |     P=0.138N     P=0.118N     P=0.141N     P=0.124N    |P=0.139N     P=0.128N     P=0.118N     P=0.124N     | 
|LOGISTIC REGRESSION|     P=0.148N     P=0.106N     P=0.145N     P=0.119N    |P=0.137N     P=0.085N     P=0.086N     P=0.090N     | 
|COCH-ARM / FISHERS |     P=0.142N     P=0.121N     P=0.121N     P=0.121N    |P=0.149N     P=0.121N     P=0.121N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Epidermis                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   44/50 (88%)  45/50 (90%)  49/50 (98%) |14/50 (28%)  50/50 (100%) 46/50 (92%)  50/50 (100%) | 
|POLY-3 RATE (b)    |     5/47.37      44/48.38     45/47.73     49/49.62    |14/44.21     50/50.00     46/48.33     50/50.00     | 
|POLY-3 PERCENT (g) |     10.6%        91.0%        94.3%        98.8%       |31.7%        100.0%       95.2%        100.0%       | 
|TERMINAL (d)       |     4/37 (11%)   40/43 (93%)  34/34 (100%) 40/40 (100%)|14/35 (40%)  34/34 (100%) 39/41 (95%)  32/32 (100%) | 
|FIRST INCIDENCE    |     684          502          439          399         |729 (T)      221          62           70           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Epidermis                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    11/50 (22%)  33/50 (66%)  42/50 (84%) |1/50 (2%)    2/50 (4%)    20/50 (40%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     1/47.21      11/47.16     33/44.68     42/49.10    |1/44.21      2/43.59      20/46.20     32/47.07     | 
|POLY-3 PERCENT (g) |     2.1%         23.3%        73.9%        85.5%       |2.3%         4.6%         43.3%        68.0%        | 
|TERMINAL (d)       |     1/37 (3%)    9/43 (21%)   28/34 (82%)  35/40 (88%) |1/35 (3%)    2/34 (6%)    17/41 (42%)  22/32 (69%)  | 
|FIRST INCIDENCE    |     726 (T)      676          517          399         |729 (T)      729 (T)      573          527          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.490      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.495      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.494      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.497      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.490      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Epidermis                                                                                            | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    20/50 (40%)  47/50 (94%) |1/50 (2%)    1/50 (2%)    6/50 (12%)   17/50 (34%)  | 
|POLY-3 RATE (b)    |     0/47.21      3/46.90      20/43.45     47/49.06    |1/44.21      1/43.59      6/45.19      17/45.04     | 
|POLY-3 PERCENT (g) |     0.0%         6.4%         46.0%        95.8%       |2.3%         2.3%         13.3%        37.7%        | 
|TERMINAL (d)       |     0/37 (0%)    3/43 (7%)    19/34 (56%)  39/40 (98%) |1/35 (3%)    1/34 (3%)    5/41 (12%)   14/32 (44%)  | 
|FIRST INCIDENCE    |     ---          726 (T)      699          399         |729 (T)      729 (T)      586          527          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.149      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.755      P=0.082      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.118      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.758      P=0.059      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.117      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.757      P=0.056      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.119      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.759      P=0.066      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.149      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.755      P=0.059      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.121      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.753N     P=0.056      P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue, Site of Application - Dermis                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    15/50 (30%)  40/50 (80%)  49/50 (98%) |4/50 (8%)    27/50 (54%)  31/50 (62%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     1/47.37      15/47.55     40/46.51     49/49.62    |4/44.26      27/45.28     31/46.56     44/47.32     | 
|POLY-3 PERCENT (g) |     2.1%         31.6%        86.0%        98.8%       |9.0%         59.6%        66.6%        93.0%        | 
|TERMINAL (d)       |     0/37 (0%)    12/43 (28%)  32/34 (94%)  40/40 (100%)|3/35 (9%)    22/34 (65%)  26/41 (63%)  31/32 (97%)  | 
|FIRST INCIDENCE    |     684          615          443          399         |717          510          573          527          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/46.93      1/47.09      0/43.35      1/46.34     |1/44.21      2/44.69      1/45.48      1/44.46      | 
|POLY-3 PERCENT (g) |     8.5%         2.1%         0.0%         2.2%        |2.3%         4.5%         2.2%         2.3%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |1/35 (3%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     628          676          ---          644         |729 (T)      221          447          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.249N     P=0.177N     P=0.087N     P=0.192N    |P=0.543N     P=0.494      P=0.748N     P=0.759N     | 
|POLY 3             |     P=0.228N     P=0.178N     P=0.071N     P=0.183N    |P=0.546N     P=0.504      P=0.754N     P=0.759N     | 
|POLY 1.5           |     P=0.228N     P=0.177N     P=0.066N     P=0.179N    |P=0.548N     P=0.501      P=0.759N     P=0.760      | 
|POLY 6             |     P=0.230N     P=0.177N     P=0.077N     P=0.187N    |P=0.545N     P=0.507      P=0.746N     P=0.757N     | 
|LOGISTIC REGRESSION|     P=0.223N     P=0.153N     P=0.049N*    P=0.141N    |P=0.485N     P=0.607      P=0.765      P=0.762      | 
|COCH-ARM / FISHERS |     P=0.232N     P=0.175N     P=0.056N     P=0.175N    |P=0.545N     P=0.500      P=0.747      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/49 (29%)  20/50 (40%)  17/50 (34%)  19/50 (38%) |32/50 (64%)  24/50 (48%)  30/49 (61%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     14/46.99     20/49.07     17/48.73     19/48.63    |32/48.20     24/45.57     30/46.64     33/49.12     | 
|POLY-3 PERCENT (g) |     29.8%        40.8%        34.9%        39.1%       |66.4%        52.7%        64.3%        67.2%        | 
|TERMINAL (d)       |     11/37 (30%)  16/43 (37%)  5/34 (15%)   13/40 (33%) |22/35 (63%)  18/34 (53%)  26/41 (63%)  19/32 (59%)  | 
|FIRST INCIDENCE    |     580          334          439          399         |329          444          444          70           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347      P=0.278      P=0.255      P=0.264     |P=0.131      P=0.130N     P=0.193N     P=0.384      | 
|POLY 3             |     P=0.342      P=0.181      P=0.377      P=0.230     |P=0.279      P=0.122N     P=0.501N     P=0.553      | 
|POLY 1.5           |     P=0.339      P=0.172      P=0.367      P=0.225     |P=0.249      P=0.110N     P=0.498N     P=0.532      | 
|POLY 6             |     P=0.345      P=0.197      P=0.395      P=0.239     |P=0.313      P=0.136N     P=0.489N     P=0.577      | 
|LOGISTIC REGRESSION|     P=0.380      P=0.175      P=0.562N     P=0.252     |P=0.190      P=0.085N     P=0.462N     P=0.503      | 
|COCH-ARM / FISHERS |     P=0.334      P=0.162      P=0.358      P=0.217     |P=0.191      P=0.079N     P=0.469N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      1/43.42      1/46.04     |0/44.21      1/43.84      2/45.37      0/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         2.2%        |0.0%         2.3%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          708          726 (T)     |---          665          573          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.315      (e)          P=0.468      P=0.516     |P=0.495N     P=0.525      P=0.251      (e)          | 
|POLY 3             |     P=0.307      (e)          P=0.483      P=0.495     |P=0.499N     P=0.498      P=0.243      (e)          | 
|POLY 1.5           |     P=0.311      (e)          P=0.489      P=0.497     |P=0.501N     P=0.497      P=0.238      (e)          | 
|POLY 6             |     P=0.303      (e)          P=0.478      P=0.494     |P=0.496N     P=0.500      P=0.252      (e)          | 
|LOGISTIC REGRESSION|     P=0.311      (e)          P=0.487      P=0.516     |P=0.495N     P=0.506      P=0.253      (e)          | 
|COCH-ARM / FISHERS |     P=0.315      (e)          P=0.500      P=0.500     |P=0.500N     P=0.500      P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/47.21      0/46.90      3/44.18      2/46.88     |0/44.21      1/43.80      0/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     6.4%         0.0%         6.8%         4.3%        |0.0%         2.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     3/37 (8%)    0/43 (0%)    1/34 (3%)    1/40 (3%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          487          399         |---          674          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.584      P=0.096N     P=0.622      P=0.472N    |P=0.460      P=0.516      (e)          P=0.482      | 
|POLY 3             |     P=0.582      P=0.120N     P=0.631      P=0.503N    |P=0.464      P=0.498      (e)          P=0.500      | 
|POLY 1.5           |     P=0.585      P=0.120N     P=0.642      P=0.502N    |P=0.463      P=0.497      (e)          P=0.499      | 
|POLY 6             |     P=0.577      P=0.118N     P=0.622      P=0.504N    |P=0.466      P=0.500      (e)          P=0.502      | 
|LOGISTIC REGRESSION|     P=0.605      (e)          P=0.620N     P=0.419N    |P=0.464      P=0.504      (e)          P=0.482      | 
|COCH-ARM / FISHERS |     P=0.583      P=0.121N     P=0.661N     P=0.500N    |P=0.464      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      2/43.50      0/46.04     |0/44.21      1/43.72      0/44.71      1/44.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.6%         0.0%        |0.0%         2.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          705          ---         |---          698          ---          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.693N     (e)          P=0.209      (e)         |P=0.481      P=0.495      (e)          P=0.520      | 
|POLY 3             |     P=0.695N     (e)          P=0.219      (e)         |P=0.465      P=0.498      (e)          P=0.501      | 
|POLY 1.5           |     P=0.691N     (e)          P=0.226      (e)         |P=0.463      P=0.497      (e)          P=0.499      | 
|POLY 6             |     P=0.699N     (e)          P=0.214      (e)         |P=0.468      P=0.499      (e)          P=0.504      | 
|LOGISTIC REGRESSION|     P=0.687N     (e)          P=0.222      (e)         |P=0.464      P=0.498      (e)          P=0.501      | 
|COCH-ARM / FISHERS |     P=0.685N     (e)          P=0.247      (e)         |P=0.464      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     4/47.21      2/47.29      1/43.35      2/46.04     |                                                    | 
|POLY-3 PERCENT (g) |     8.5%         4.2%         2.3%         4.3%        |                                                    | 
|TERMINAL (d)       |     4/37 (11%)   1/43 (2%)    1/34 (3%)    2/40 (5%)   |                                                    | 
|FIRST INCIDENCE    |     726 (T)      615          726 (T)      726 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.382N     P=0.284N     P=0.205N     P=0.301N    |                                                    | 
|POLY 3             |     P=0.394N     P=0.337N     P=0.206N     P=0.349N    |                                                    | 
|POLY 1.5           |     P=0.391N     P=0.339N     P=0.196N     P=0.345N    |                                                    | 
|POLY 6             |     P=0.399N     P=0.329N     P=0.216N     P=0.352N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.397N     P=0.337N     P=0.205N     P=0.301N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.388N     P=0.339N     P=0.181N     P=0.339N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/47.21      2/47.29      1/43.60      0/46.04     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         2.3%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/37 (0%)    1/43 (2%)    0/34 (0%)    0/40 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          615          659          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.388N     P=0.254      P=0.477      (e)         |                                                    | 
|POLY 3             |     P=0.386N     P=0.238      P=0.484      (e)         |                                                    | 
|POLY 1.5           |     P=0.385N     P=0.237      P=0.490      (e)         |                                                    | 
|POLY 6             |     P=0.387N     P=0.241      P=0.479      (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.371N     P=0.258      P=0.552      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.381N     P=0.247      P=0.500      (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/48 (79%)  37/47 (79%)  37/48 (77%)  38/48 (79%) |13/49 (27%)  17/49 (35%)  19/49 (39%)  16/49 (33%)  | 
|POLY-3 RATE (b)    |     38/48.00     37/46.33     37/44.83     38/46.95    |13/46.80     17/47.65     19/46.49     16/47.01     | 
|POLY-3 PERCENT (g) |     79.2%        79.9%        82.5%        80.9%       |27.8%        35.7%        40.9%        34.0%        | 
|TERMINAL (d)       |     26/36 (72%)  32/41 (78%)  26/32 (81%)  31/38 (82%) |3/34 (9%)    6/34 (18%)   15/40 (38%)  5/31 (16%)   | 
|FIRST INCIDENCE    |     511          334          439          399         |329          221          62           70           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.504      P=0.244N     P=0.339      P=0.484N    |P=0.407      P=0.292      P=0.256      P=0.337      | 
|POLY 3             |     P=0.488      P=0.568      P=0.440      P=0.517     |P=0.451      P=0.274      P=0.132      P=0.333      | 
|POLY 1.5           |     P=0.517      P=0.587      P=0.540      P=0.553     |P=0.450      P=0.268      P=0.133      P=0.331      | 
|POLY 6             |     P=0.439      P=0.550      P=0.344      P=0.465     |P=0.453      P=0.276      P=0.133      P=0.336      | 
|LOGISTIC REGRESSION|     P=0.527      P=0.574N     P=0.565      P=0.581N    |P=0.442      P=0.250      P=0.148      P=0.320      | 
|COCH-ARM / FISHERS |     P=0.545      P=0.578N     P=0.500N     P=0.599N    |P=0.454      P=0.256      P=0.141      P=0.329      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.21      0/46.90      0/42.55      0/46.04     |0/44.21      0/43.59      0/44.71      2/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.5%         | 
|TERMINAL (d)       |     0/37 (0%)    0/43 (0%)    0/34 (0%)    0/40 (0%)   |0/35 (0%)    0/34 (0%)    0/41 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.032 *    (e)          (e)          P=0.219      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.237      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.236      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.239      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.219      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.21      1/46.90      0/42.55      1/46.39     |1/44.21      1/43.59      2/44.71      1/44.29      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         2.2%        |2.3%         2.3%         4.5%         2.3%         | 
|TERMINAL (d)       |     1/37 (3%)    1/43 (2%)    0/34 (0%)    0/40 (0%)   |1/35 (3%)    1/34 (3%)    2/41 (5%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          628         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.673      P=0.728N     P=0.517N     P=0.757N    |P=0.655      P=0.755      P=0.555      P=0.742      | 
|POLY 3             |     P=0.671      P=0.759      P=0.521N     P=0.757     |P=0.633N     P=0.758      P=0.504      P=0.760N     | 
|POLY 1.5           |     P=0.672      P=0.759      P=0.515N     P=0.758     |P=0.635N     P=0.757      P=0.498      P=0.759      | 
|POLY 6             |     P=0.671      P=0.760N     P=0.526N     P=0.756     |P=0.631N     P=0.759      P=0.515      P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.677      P=0.728N     (e)          P=0.742N    |P=0.655      P=0.755      P=0.555      P=0.742      | 
|COCH-ARM / FISHERS |     P=0.675      P=0.753N     P=0.505N     P=0.753N    |P=0.636N     P=0.753N     P=0.500      P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/19 (100%) 18/18 (100%) 14/14 (100%) 13/13 (100%)|0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     19/19.00     18/18.00     14/14.00     13/13.00    |0/0.00       0/0.00       0/1.00       0/0.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     14/14 (100%) 18/18 (100%) 11/11 (100%) 11/11 (100%)|0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     624          726 (T)      603          644         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.21      2/43.59      2/45.19      2/44.31      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         4.6%         4.4%         4.5%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    2/34 (6%)    1/41 (2%)    1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      586          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.469      P=0.490      P=0.529      P=0.476      | 
|POLY 3             |                                                        |P=0.503      P=0.495      P=0.508      P=0.501      | 
|POLY 1.5           |                                                        |P=0.500      P=0.494      P=0.500      P=0.498      | 
|POLY 6             |                                                        |P=0.505      P=0.497      P=0.521      P=0.504      | 
|LOGISTIC REGRESSION|                                                        |P=0.502      P=0.490      P=0.502      P=0.497      | 
|COCH-ARM / FISHERS |                                                        |P=0.500      P=0.500      P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/06/02                           EXPERIMENT: 05109 TEST: 14                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  TRIETHANOLAMINE       
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      200          630          2000        |0 MG/KG      100          300          1000         | 
|                   |                  MG/KG        MG/KG        MG/KG       |             MG/KG        MG/KG        MG/KG        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |49/50 (98%)  48/50 (96%)  47/50 (94%)  47/50 (94%)  | 
|POLY-3 RATE (b)    |                                                        |49/49.68     48/48.57     47/48.23     47/48.60     | 
|POLY-3 PERCENT (g) |                                                        |98.6%        98.8%        97.5%        96.7%        | 
|TERMINAL (d)       |                                                        |35/35 (100%) 34/34 (100%) 40/41 (98%)  32/32 (100%) | 
|FIRST INCIDENCE    |                                                        |329          221          338          410          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.418      P=0.568N     P=0.065N     P=0.506      | 
|POLY 3             |                                                        |P=0.353N     P=0.871      P=0.633N     P=0.517N     | 
|POLY 1.5           |                                                        |P=0.396N     P=0.747N     P=0.582N     P=0.498N     | 
|POLY 6             |                                                        |P=0.322N     P=0.933      P=0.636N     P=0.533N     | 
|LOGISTIC REGRESSION|                                                        |P=0.316N     P=0.625N     P=0.460N     P=0.393N     | 
|COCH-ARM / FISHERS |                                                        |P=0.300N     P=0.500N     P=0.309N     P=0.309N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.