Share This:
https://ntp.niehs.nih.gov/go/917

TDMS Study 05109-14 Pathology Tables

NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51

                                                         FINAL #1/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  102-71-6

       Lock Date:  05/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                           0 MG/KG      100          300          1000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            6            4            7                                     
    Moribund Sacrifice                                 8           10            5           10                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           34           41           32                                     
    Natural Death                                      1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Serosa, Inflammation, Chronic                                              1 [3.0]                                            
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Epithelium, Necrosis                             1 [1.0]                                                                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Diverticulum                                                                            1 [2.0]                               
      Ulcer                                                         1 [3.0]                                                         
      Peyer's Patch, Hyperplasia                       1 [4.0]                                                                      
      Peyer's Patch, Inflammation, Suppurative                                   1 [3.0]                                            
      Serosa, Inflammation, Granulomatous                                                     1 [2.0]                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                         1 [1.0]                                            
      Basophilic Focus                                 4                         3            3                                     
      Clear Cell Focus                                 4            3            3            5                                     
      Eosinophilic Focus                              16           22           28           32                                     
      Fibrosis, Focal                                  1 [2.0]                                                                      
      Hematopoietic Cell Proliferation                 4 [1.0]      3 [1.7]      3 [1.7]      4 [2.8]                               
      Hepatodiaphragmatic Nodule                                    2 [1.0]                                                         
      Infiltration Cellular, Lymphoid                 26 [1.0]     30 [1.2]     36 [1.2]     20 [1.1]                               
      Inflammation, Chronic                           14 [1.0]     27 [1.0]     22 [1.0]     15 [1.0]                               
      Mixed Cell Focus                                 5            8           14           11                                     
      Necrosis, Focal                                               5 [1.4]      1 [1.0]      3 [2.3]                               
      Vacuolization Cytoplasmic, Focal                 8 [1.3]      1 [1.0]      6 [1.0]      6 [1.2]                               
      Centrilobular, Cytomegaly, Diffuse                                         1 [3.0]                                            
      Centrilobular, Necrosis                          1 [2.0]                   1 [3.0]                                            
   Mesentery                                          (11)         (6)          (4)          (9)                                    
      Inflammation, Chronic                            1 [2.0]                                                                      
      Fat, Necrosis                                   10 [2.5]      6 [2.2]      3 [2.3]      9 [2.3]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                           0 MG/KG      100          300          1000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Lymphatic, Angiectasis                           1 [2.0]                                                                      
   Oral Mucosa                                        (26)         (26)         (31)         (31)                                   
      Inflammation, Chronic                           26 [1.5]     26 [1.7]     31 [1.7]     31 [1.5]                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  1 [4.0]      3 [3.3]      1 [2.0]                                            
      Acinus, Hyperplasia                                           1 [2.0]                                                         
      Duct, Cyst                                       1 [3.0]      2 [3.5]      1 [4.0]                                            
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 [2.0]                                1 [2.0]                               
      Inflammation, Suppurative                                     1 [2.0]                                                         
      Ulcer                                                         1 [1.0]      2 [1.5]                                            
      Epithelium, Cyst                                                                        1 [2.0]                               
      Epithelium, Hyperplasia, Focal                                1 [2.0]                   1 [3.0]                               
      Epithelium, Mineralization                                                 1 [1.0]                                            
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                                                        1 [1.0]                                            
      Ulcer                                                         1 [2.0]                   1 [2.0]                               
      Epithelium, Cyst                                 1 [1.0]                   1 [1.0]                                            
      Epithelium, Hyperplasia, Focal                   1 [2.0]                   1 [2.0]      1 [3.0]                               
      Serosa, Inflammation, Chronic                                                           1 [2.0]                               
   Tooth                                                                        (1)                                                 
      Inflammation, Chronic                                                      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic                                               2 [1.0]                                            
      Aorta, Mineralization                            1 [2.0]      2 [3.0]                                                         
   Heart                                              (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic                    3 [1.0]      1 [1.0]      2 [2.0]      1 [1.0]                               
      Atrium, Thrombosis                               2 [4.0]                                                                      
      Myocardium, Degeneration                         4 [2.0]                   1 [3.0]                                            
      Myocardium, Inflammation, Acute                  1 [1.0]                                                                      
      Myocardium, Inflammation, Chronic                                          1 [1.0]                                            
      Myocardium, Mineralization                       1 [1.0]      2 [2.5]                                                         
      Myocardium, Necrosis                                                       1 [3.0]                                            
      Pericardium, Inflammation, Chronic                                         1 [2.0]                                            
      Valve, Inflammation                                                                     1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                           0 MG/KG      100          300          1000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                 1 [3.0]                                                                      
      Hyperplasia, Focal                               1 [1.0]      1 [1.0]                                                         
      Hypertrophy, Focal                                            2 [2.0]      1 [1.0]      1 [1.0]                               
      Inflammation, Suppurative                                                  1 [1.0]                                            
      Subcapsular, Hyperplasia                        49 [1.7]     49 [2.0]     50 [1.9]     50 [1.9]                               
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                                            1 [2.0]      1 [2.0]                                            
      Infiltration Cellular, Histiocyte                                          1 [2.0]                                            
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     25 [1.3]     18 [1.4]     20 [1.5]     18 [1.3]                               
   Parathyroid Gland                                  (39)         (41)         (45)         (46)                                   
      Cyst                                                                       1 [2.0]                                            
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 [4.0]                                            
      Pars Distalis, Hyperplasia                      11 [1.5]      3 [2.0]      9 [1.8]     12 [1.6]                               
      Pars Intermedia, Hyperplasia                                  1 [2.0]                                                         
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                      1 [1.0]                   1 [1.0]                                            
      C-Cell, Hyperplasia                                                                     2 [2.0]                               
      Follicle, Cyst                                   1 [2.0]      1 [2.0]      2 [1.5]      1 [2.0]                               
      Follicular Cell, Necrosis                        1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (49)         (49)                                   
      Cyst                                             2 [1.0]                                1 [2.0]                               
      Inflammation, Suppurative                        1 [2.0]                                                                      
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 [2.0]                   2 [2.0]                                            
      Cyst                                            27 [1.7]     22 [2.0]     21 [2.0]     25 [2.0]                               
      Mineralization                                                                          1 [2.0]                               
      Thrombosis                                                    1 [2.0]      3 [4.0]      1 [4.0]                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [2.0]      2 [2.5]      2 [3.0]      2 [2.5]                               
      Thrombosis                                                    1 [3.0]      1 [4.0]                                            
      Endometrium, Hyperplasia, Cystic                49 [2.5]     48 [2.3]     47 [2.7]     47 [2.8]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                           0 MG/KG      100          300          1000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                   1 [1.0]                                            
      Myeloid Cell, Hyperplasia                        1 [4.0]                                                                      
   Lymph Node                                         (6)          (7)          (4)          (6)                                    
      Deep Cervical, Hyperplasia, Lymphoid                          1 [4.0]                                                         
      Iliac, Hyperplasia, Lymphoid                                  1 [3.0]      1 [4.0]                                            
      Lumbar, Hyperplasia, Lymphoid                    1 [3.0]                   1 [4.0]                                            
      Lumbar, Inflammation, Acute                      1 [3.0]                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 [2.0]      1 [3.0]                   2 [2.5]                               
      Renal, Hyperplasia, Lymphoid                                                            1 [4.0]                               
   Lymph Node, Mandibular                             (49)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Hyperplasia, Lymphoid                            1 [3.0]                   2 [3.0]                                            
   Lymph Node, Mesenteric                             (50)         (49)         (48)         (48)                                   
      Hyperplasia, Histiocytic                                                   1 [3.0]                                            
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Atrophy                                          1 [2.0]      2 [3.0]      1 [3.0]      1 [4.0]                               
      Hematopoietic Cell Proliferation                32 [1.8]     24 [1.5]     30 [1.5]     33 [1.6]                               
      Hyperplasia, Lymphoid                                                      1 [1.0]                                            
   Thymus                                             (49)         (49)         (49)         (49)                                   
      Atrophy                                         13 [2.5]     17 [2.7]     19 [2.5]     16 [2.6]                               
      Hyperplasia, Focal                               1 [2.0]                                                                      
      Hyperplasia, Histiocytic                         1 [4.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Duct, Dilatation                                 1 [1.0]                   1 [1.0]                                            
   Skin                                               (50)         (50)         (50)         (50)                                   
      Epidermis, Hyperkeratosis                        1 [1.0]                                                                      
      Epidermis, Hyperplasia                           1 [1.0]                                                                      
      Epidermis, Inflammation, Suppurative             1 [2.0]                                                                      
      Epidermis, Ulcer                                 1 [4.0]                                                                      
      Site of Application - Epidermis,                                                                                              
          Hyperkeratosis                               3 [1.0]                                                                      
      Site of Application - Epidermis, Hyperplasia    14 [1.3]     50 [1.9]     46 [2.0]     50 [2.0]                               
      Site of Application - Epidermis,                                                                                              
          Inflammation, Suppurative                    1 [2.0]      2 [2.0]     20 [1.5]     32 [2.2]                               
      Site of Application - Epidermis, Ulcer           1 [3.0]      1 [3.0]      6 [1.5]     17 [1.6]                               
      Subcutaneous Tissue, Edema                                    1 [3.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                           0 MG/KG      100          300          1000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Fibrosis                                                           1 [3.0]                               
      Subcutaneous Tissue, Inflammation, Chronic       1 [4.0]                                                                      
      Subcutaneous Tissue, Necrosis                    1 [2.0]                                                                      
      Subcutaneous Tissue, Site of Application -                                                                                    
          Dermis, Inflammation, Chronic                4 [1.8]     27 [1.1]     31 [1.6]     44 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                         7 [1.1]      6 [2.0]     13 [1.5]     10 [1.1]                               
      Fracture                                                                                1 [1.0]                               
      Hyperostosis                                                  1 [2.0]                                                         
      Cranium, Callus                                                            1 [2.0]                                            
      Femur, Hyperostosis                                           1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 [1.0]                               
      Hydrocephalus                                                              1 [1.0]                                            
      Artery, Inflammation, Chronic                                              1 [2.0]                                            
      Artery, Meninges, Inflammation, Chronic                       1 [2.0]                                                         
      Hypothalamus, Compression                                                  3 [3.7]      1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                              1 [4.0]                                                                      
      Inflammation, Chronic                            2 [1.0]                   3 [1.0]      1 [1.0]                               
      Inflammation, Granulomatous                      1 [1.0]                                                                      
      Mineralization                                                2 [3.0]                                                         
      Alveolar Epithelium, Hyperplasia, Focal                                    1 [1.0]      1 [1.0]                               
      Bronchus, Hyperplasia, Focal                     1 [1.0]                                                                      
      Bronchus, Hyperplasia, Lymphoid                  1 [2.0]                                                                      
      Mediastinum, Inflammation, Chronic                                         1 [3.0]                                            
      Serosa, Inflammation, Chronic                                              1 [3.0]                                            
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                      1 [1.0]                                            
      Sinus, Inflammation, Suppurative                                                        1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 FEMALE                           0 MG/KG      100          300          1000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (50)         (50)         (50)                                   
      Degeneration                                     1 [1.0]                                                                      
      Inflammation, Chronic                                         1 [3.0]                                                         
   Harderian Gland                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      4 [2.0]      3 [3.0]      4 [2.0]      5 [2.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                1 [2.0]                                                         
      Infarct                                          1 [1.0]      5 [1.4]      3 [1.0]      3 [1.0]                               
      Metaplasia, Osseous                                                        1 [1.0]      3 [1.0]                               
      Nephropathy                                     24 [1.0]     18 [1.1]     23 [1.0]     20 [1.1]                               
      Glomerulus, Amyloid Deposition                                2 [3.0]                                                         
      Glomerulus, Cyst                                                                        1 [2.0]                               
      Papilla, Necrosis                                1 [1.0]      1 [2.0]                   1 [2.0]                               
      Papilla, Renal Tubule, Atrophy                                                          1 [1.0]                               
      Pelvis, Inflammation, Granulomatous                                        1 [1.0]                                            
      Renal Tubule, Cyst                                                         1 [1.0]                                            
      Renal Tubule, Cytoplasmic Alteration                          1 [4.0]                                                         
      Renal Tubule, Mineralization                                                            1 [2.0]                               
   Urinary Bladder                                    (50)         (50)         (49)         (49)                                   
      Cyst                                                                                    1 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                             0 MG/KG      200          630          2000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            2            6            8                                     
    Natural Death                                      8            5           10            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           43           34           40                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (49)         (50)         (47)                                   
      Necrosis                                         1 [4.0]                                                                      
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                      1 [3.0]                                            
      Goblet Cell, Hyperplasia                                                   1 [4.0]                                            
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 [4.0]                                            
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Epithelium, Hyperplasia                          1 [2.0]                                                                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Diverticulum                                     1 [1.0]                                                                      
      Epithelium, Hyperplasia                                       1 [2.0]                                                         
      Peyer's Patch, Hyperplasia, Lymphoid             1 [1.0]                                1 [2.0]                               
      Serosa, Inflammation, Granulomatous                           1 [3.0]                                                         
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Muscularis, Infiltration Cellular,                                                                                            
          Mononuclear Cell                                                       1 [2.0]                                            
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 2            6            3            2                                     
      Clear Cell Focus                                19           23           14           11                                     
      Eosinophilic Focus                               9           20           31           30                                     
      Fibrosis                                                      1 [1.0]                                                         
      Hematopoietic Cell Proliferation                 3 [1.0]      4 [1.3]      1 [1.0]      2 [1.5]                               
      Hepatodiaphragmatic Nodule                       1                         1                                                  
      Infiltration Cellular, Lymphoid                  3 [1.0]      2 [1.5]      2 [1.5]      3 [1.0]                               
      Inflammation, Acute                              1 [2.0]                                                                      
      Inflammation, Chronic                            9 [1.0]     14 [1.1]     10 [1.0]     11 [1.0]                               
      Mixed Cell Focus                                13           11           15            8                                     
      Necrosis, Focal                                  4 [1.8]      3 [1.3]      7 [2.0]      6 [1.3]                               
      Vacuolization Cytoplasmic, Focal                 2 [1.0]      1 [1.0]      3 [1.0]      5 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                             0 MG/KG      200          630          2000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis                                       1 [2.0]      1 [3.0]                                            
   Mesentery                                          (3)          (3)          (5)          (7)                                    
      Inflammation, Granulomatous                                                1 [1.0]                                            
      Artery, Inflammation, Chronic                                                           1 [3.0]                               
      Fat, Necrosis                                    3 [2.0]      3 [2.7]      4 [2.3]      5 [1.8]                               
   Oral Mucosa                                        (31)         (26)         (35)         (30)                                   
      Inflammation, Chronic                           31 [1.9]     26 [1.9]     35 [1.8]     30 [1.7]                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                               1 [1.0]                                                         
      Duct, Cyst                                                                              1 [3.0]                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 [2.0]                                                                      
      Ulcer                                                                      1 [2.0]      1 [2.0]                               
      Epithelium, Cyst                                                                        1 [2.0]                               
      Epithelium, Hyperplasia, Focal                   3 [2.0]                   3 [1.7]      2 [1.5]                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                                                   1 [2.0]                               
      Ulcer                                                                      2 [2.0]                                            
      Epithelium, Hyperplasia, Focal                                                          1 [2.0]                               
      Glands, Ectasia                                               1 [1.0]                                                         
   Tooth                                              (19)         (18)         (14)         (13)                                   
      Malformation                                    19 [2.2]     18 [1.8]     14 [2.0]     13 [1.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic                                                            1 [1.0]                               
      Aorta, Mineralization                                         1 [2.0]                                                         
      Pulmonary Vein, Thrombosis                                                              1 [2.0]                               
   Heart                                              (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mononuclear Cell          3 [1.0]      1 [2.0]                                                         
      Inflammation, Acute                              1 [3.0]                                                                      
      Inflammation, Chronic                                                                   2 [1.5]                               
      Artery, Inflammation, Chronic                                 1 [1.0]                   3 [2.0]                               
      Atrium, Thrombosis                               1 [4.0]      1 [4.0]                                                         
      Coronary Artery, Inflammation, Chronic                                                  1 [2.0]                               
      Myocardium, Degeneration                                      1 [2.0]                                                         
      Myocardium, Mineralization                       1 [1.0]                   1 [1.0]      2 [1.0]                               
      Valve, Inflammation, Chronic                                  1 [3.0]                                                         
      Ventricle, Thrombosis                            1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                             0 MG/KG      200          630          2000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                               8 [1.5]      4 [1.5]      3 [1.0]      1 [1.0]                               
      Hypertrophy, Focal                              16 [1.6]     21 [1.3]     10 [1.2]     10 [1.3]                               
      Necrosis                                                                   1 [3.0]                                            
      Subcapsular, Hyperplasia                        39 [1.2]     45 [1.2]     40 [1.5]     40 [1.3]                               
      Zona Glomerulosa, Hyperplasia                                 2 [2.5]      3 [2.0]      1 [1.0]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                                                                      2 [2.0]                               
      Necrosis                                                                   1 [3.0]                                            
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     45 [2.2]     43 [2.0]     43 [1.9]     32 [1.6]                               
   Pituitary Gland                                    (50)         (49)         (49)         (50)                                   
      Pars Distalis, Hyperplasia                       1 [2.0]      2 [1.0]                   1 [3.0]                               
      Pars Intermedia, Hyperplasia                     1 [2.0]                                3 [2.3]                               
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Follicle, Cyst                                   1 [1.0]      1 [1.0]                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (1)          (1)                                    
      Cyst                                                                       1 [1.0]                                            
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 [3.0]                   1 [2.0]      2 [2.0]                               
      Inflammation, Chronic                                         1 [1.0]                                                         
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 [2.0]                                                         
      Cyst                                            10 [1.9]     14 [2.1]     11 [2.1]     15 [2.1]                               
      Inflammation, Chronic                            1 [2.0]                                2 [1.5]                               
      Inflammation, Suppurative                                     1 [2.0]                   3 [2.7]                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 [2.0]                                                         
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 [2.0]                               
      Hyperplasia                                      1 [1.0]      2 [1.0]      2 [2.0]                                            
   Testes                                             (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                                             1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                             0 MG/KG      200          630          2000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Germinal Epithelium, Atrophy                     4 [1.3]      2 [1.0]      1 [1.0]      2 [1.0]                               
      Germinal Epithelium, Mineralization                           2 [1.5]      1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mesenteric                             (50)         (48)         (48)         (50)                                   
      Congestion                                                                 1 [3.0]                                            
      Hyperplasia, Lymphoid                                                      1 [4.0]                                            
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Atrophy                                          4 [3.5]      1 [3.0]                   1 [2.0]                               
      Hematopoietic Cell Proliferation                14 [1.6]     20 [1.5]     17 [1.7]     19 [1.5]                               
      Lymphoid Follicle, Hematopoietic Cell                                                                                         
          Proliferation                                1 [1.0]                   1 [2.0]                                            
      Red Pulp, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         1 [2.0]                                                                      
   Thymus                                             (48)         (47)         (48)         (48)                                   
      Atrophy                                         38 [2.8]     37 [2.3]     37 [2.4]     38 [2.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Dermis, Edema                                                              1 [3.0]                                            
      Epidermis, Hyperkeratosis                        1 [1.0]                                                                      
      Epidermis, Ulcer                                 1 [3.0]                                                                      
      Site of Application - Epidermis,                                                                                              
          Hyperkeratosis                               3 [1.0]                                                                      
      Site of Application - Epidermis, Hyperplasia     5 [1.2]     44 [1.5]     45 [2.0]     49 [2.7]                               
      Site of Application - Epidermis,                                                                                              
          Inflammation, Suppurative                    1 [1.0]     11 [1.5]     33 [1.7]     42 [2.8]                               
      Site of Application - Epidermis, Ulcer                        3 [1.0]     20 [1.4]     47 [2.6]                               
      Subcutaneous Tissue, Site of Application -                                                                                    
          Dermis, Inflammation, Chronic                1 [1.0]     15 [1.1]     40 [1.6]     49 [2.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                   1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                             0 MG/KG      200          630          2000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                                                             1 [3.0]                               
   Spinal Cord                                        (1)                                                                           
      Necrosis                                         1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                                            1 [2.0]                                            
      Inflammation, Acute                                           1 [3.0]                                                         
      Inflammation, Chronic                            1 [2.0]                                                                      
      Inflammation, Granulomatous                      2 [1.0]                                                                      
      Alveolar Epithelium, Hyperplasia, Focal          2 [1.0]      2 [1.5]      1 [1.0]      2 [1.5]                               
      Bronchus, Hyperplasia, Focal                                  1 [2.0]                                                         
      Perivascular, Infiltration Cellular, Lymphoid                                           1 [3.0]                               
      Vein, Thrombosis                                                                        1 [2.0]                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        2 [1.0]                   1 [1.0]                                            
      Polyp, Inflammatory                                           1 [3.0]                                                         
      Respiratory Epithelium, Mineralization                                                  1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Degeneration                                     1 [4.0]                                                                      
      Cornea, Inflammation, Acute                                                             1 [2.0]                               
      Retrobulbar, Inflammation, Suppurative           1 [3.0]                                                                      
   Harderian Gland                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      3 [1.3]      5 [1.6]      6 [1.8]      7 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                1 [2.0]                                                         
      Infarct                                          2 [1.5]      3 [1.0]      2 [1.0]      4 [1.5]                               
      Inflammation, Acute                              2 [2.5]                                                                      
      Metaplasia, Osseous                              1 [1.0]      4 [1.0]      2 [1.0]      2 [1.0]                               
      Nephropathy                                     39 [1.3]     42 [1.2]     37 [1.0]     40 [1.2]                               
      Artery, Thrombosis                                            1 [2.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 05109-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/06/02    
Route: SKIN APPLICATION                                        TRIETHANOLAMINE                                    Time: 08:45:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:B6C3F1 MALE                             0 MG/KG      200          630          2000                                   
                                                                   MG/KG        MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Capsule, Inflammation, Chronic                                             1 [2.0]                                            
      Glomerulus, Cyst                                              2 [2.5]                   2 [2.0]                               
      Papilla, Necrosis                                                          1 [3.0]                                            
      Renal Tubule, Cyst                               4 [2.3]      2 [1.5]                   4 [1.3]                               
      Renal Tubule, Hyperplasia                                     1 [1.0]      1 [1.0]      2 [1.5]                               
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             1 [4.0]                                                                      
      Inflammation, Acute                              1 [2.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------