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TDMS Study 05110-02 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Northwest                                  NAPHTHALENE                                              DATE: 03/06/00    
EXPERIMENT: 05110 TEST: 02                                                                                        TIME: 11:18:13    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                        NTP:  C52904C     
CONT: NO1-ES-55392                                                                                                CAS: 91-20-3      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE NORTHWEST                               NAPHTHALENE                                                 DATE: 03/06/00


EXPERIMENT: 05110 TEST: 02                                                                                        TIME: 11:23:33


SPECIES: RATS, FISCHER 344                             


TEST TYPE: TWO YEAR                                 ROUTE: RESPIRATORY EX                                         NTP:  52904C


CONT: NO1-ES-55392                                                                                                CAS: 91-20-3

                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
                               TWO YEAR RESPIRATORY EX STUDY OF NAPHTHALENE

==========================================================================================================
WEEK     CONTROL                10 PPM                   30 PPM                   60 PPM
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B       124.6       49       121.9     97.8    49     122.6     98.4    48*    121.6     97.6    49
  1       124.6       49       121.9     97.8    49     122.6     98.4    48*    121.6     97.6    49
  4       231.1       49       211.1     91.3    49     210.8     91.2    48*    205.6     89.0    49
  8       293.4       49       266.5     90.8    49     266.9     91.0    48     257.1     87.6    49
 12       342.5       49       313.7     91.6    49     312.4     91.2    48     302.0     88.2    49
 16       370.9       49       342.5     92.3    49     338.9     91.4    48     327.6     88.3    49
 20       396.3       49       366.7     92.5    49     360.8     91.0    48     349.6     88.2    49
 24       416.3       49       384.6     92.4    49     378.1     90.8    48     367.9     88.4    49
 28       430.5       49       401.3     93.2    49     395.7     91.9    48     381.1     88.5    49
 32       442.6       49       413.6     93.4    49     405.8     91.7    48     392.5     88.7    49
 36       455.1       49       426.1     93.6    49     419.7     92.2    48     406.6     89.3    48
 40       463.5       49       434.9     93.8    49     426.6     92.0    48     412.4     89.0    48
 44       468.7       49       439.4     93.7    49     433.0     92.4    48     417.6     89.1    48
 48       479.5       49       450.5     94.0    49     443.3     92.5    48     426.5     88.9    48
 52       478.9       49       455.2     95.1    49     448.0     93.5    48     431.6     90.1    48
 56       487.6       49       460.5     94.4    48     453.1     92.9    48     437.5     89.7    48
 60       491.5       49       463.4     94.3    48     458.4     93.3    48     438.4     89.2    47
 64       496.4       49       471.4     95.0    47     465.1     93.7    47     444.4     89.5    46
 68       504.6       46       477.2     94.6    47     471.5     93.4    47     450.2     89.2    45
 72       505.5       45       477.0     94.4    46     475.2     94.0    46     456.7     90.3    44
 76       504.5       44       475.2     94.2    43     473.6     93.9    45     450.1     89.2    42
 80       507.1       44       477.7     94.2    42     475.2     93.7    44     453.1     89.4    40
 84       505.4       43       477.5     94.5    41     485.0     96.0    40     461.5     91.3    36
 88       499.1       43       478.5     95.9    39     477.3     95.6    37     463.3     92.8    34
 92       501.0       38       474.6     94.7    38     467.3     93.3    35     462.4     92.3    31
 94       496.4       38       480.0     96.7    34     468.1     94.3    32     457.2     92.1    31
 96       499.1       34       480.2     96.2    33     470.9     94.3    31     458.9     91.9    28
 98       498.0       32       487.6     97.9    26     470.3     94.4    28     457.2     91.8    27
100       494.0       30       485.4     98.3    25     480.2     97.2    26     463.4     93.8    25
102       487.7       27       482.7     99.0    24     483.1     99.1    24     466.7     95.7    22
104       494.6       24       469.3     94.9    22     468.1     94.6    24     465.6     94.1    21

TERM. SAC.            24                         22                       23                       21


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
                               TWO YEAR RESPIRATORY EX STUDY OF NAPHTHALENE

==========================================================================================================
WEEK     CONTROL                10 PPM                   30 PPM                   60 PPM
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B       100.0       49       100.5    100.5    49     100.0    100.0    49      99.7     99.7    49
  1       100.0       49       100.5    100.5    49     100.0    100.0    49      99.7     99.7    49
  4       148.3       49       140.9     95.0    49     138.5     93.4    49     138.1     93.1    49
  8       168.6       49       161.7     95.9    49     160.3     95.1    49     158.8     94.2    49
 12       186.9       49       179.8     96.2    49     180.2     96.4    49     177.4     94.9    49
 16       195.1       49       191.1     97.9    49     190.4     97.6    49     185.1     94.9    49
 20       204.4       49       203.1     99.4    49     201.5     98.6    49     196.3     96.0    48
 24       211.4       49       211.3    100.0    49     210.1     99.4    49     201.8     95.5    48
 28       215.7       49       219.2    101.6    49     218.3    101.2    49     209.7     97.2    48
 32       217.1       49       226.2    104.2    49     224.4    103.4    49     215.3     99.2    48
 36       230.9       49       237.3    102.8    49     236.5    102.4    49     227.3     98.4    48
 40       235.8       49       241.6    102.5    49     240.7    102.1    49     229.8     97.5    48
 44       239.8       49       249.8    104.2    49     246.2    102.7    49     236.6     98.7    48
 48       253.9       49       262.4    103.3    49     257.0    101.2    49     249.0     98.1    48
 52       262.4       49       269.6    102.7    49     264.3    100.7    49     254.0     96.8    48
 56       271.8       49       280.4    103.2    49     273.4    100.6    49     262.7     96.7    48
 60       278.9       49       286.8    102.8    49     280.9    100.7    49     269.0     96.5    48
 64       287.3       49       293.9    102.3    48     287.8    100.2    47     275.5     95.9    46
 68       295.0       49       301.3    102.1    47     295.9    100.3    47     281.6     95.5    46
 72       303.0       49       307.3    101.4    47     301.7     99.6    46     289.4     95.5    44
 76       306.1       47       307.2    100.4    44     300.9     98.3    45     290.9     95.0    43
 80       313.0       47       310.0     99.0    44     306.1     97.8    45     295.7     94.5    40
 84       319.7       46       314.3     98.3    40     308.8     96.6    43     301.7     94.4    39
 88       321.7       44       313.8     97.5    37     313.8     97.5    40     301.7     93.8    38
 92       325.2       43       322.2     99.1    34     315.3     97.0    37     300.2     92.3    33
 94       318.8       43       318.0     99.7    33     316.9     99.4    35     307.6     96.5    31
 96       318.9       41       318.1     99.7    31     320.2    100.4    34     307.1     96.3    30
 98       324.7       34       328.6    101.2    26     324.3     99.9    33     309.1     95.2    27
100       324.7       33       326.5    100.6    26     324.2     99.8    32     309.4     95.3    26
102       321.1       31       326.4    101.7    25     323.8    100.8    30     305.7     95.2    26
104       320.2       29       329.5    102.9    21     328.7    102.7    28     306.9     95.8    24

TERM. SAC.            28                         21                       28                       24


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.