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TDMS Study 05110-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       NAPHTHALENE                                      DATE: 08/15/00       
EXPERIMENT: 05110 TEST: 02                                                                                     TIME: 08:28:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 52904C       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 91-20-3         
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                                                      CORE STUDY RATS/FINAL#3                                                       
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       NAPHTHALENE                                      DATE: 08/15/00       
EXPERIMENT: 05110 TEST: 02                                                                                     TIME: 08:28:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 52904C       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 91-20-3         
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Salivary Glands                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       NAPHTHALENE                                      DATE: 08/15/00       
EXPERIMENT: 05110 TEST: 02                                                                                     TIME: 08:28:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 52904C       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 91-20-3         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                   NAPHTHALENE                                                                                    
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Mammary Gland                          Fibroadenoma                                                                                 
Nose                                   Adenoma                                                                                      
                                       Neuroblastoma                                                                                
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Mammary Gland                          Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Nose                                   Neuroblastoma                                                                                
Thyroid Gland: C-Cell                  Carcinoma or Adenoma                                                                         
Uterus                                 Polyp Stromal                                                                                
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                    NAPHTHALENE            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    1/48 (2%)    2/49 (4%)   |1/49 (2%)    2/49 (4%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/41.10      0/38.97      1/38.90      2/37.46     |1/43.24      2/38.97      1/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         2.6%         5.3%        |2.3%         5.1%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    1/21 (5%)   |1/28 (4%)    1/21 (5%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     657          ---          681          419         |734 (T)      663          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.379      P=0.273N     P=0.544N     P=0.636     |P=0.239N     P=0.409      P=0.762      P=0.531N     | 
|POLY 3             |     P=0.405      P=0.249N     P=0.519N     P=0.661     |P=0.250N     P=0.464      P=0.748      P=0.526N     | 
|POLY 1.5           |     P=0.411      P=0.244N     P=0.513N     P=0.674     |P=0.240N     P=0.479      P=0.752      P=0.517N     | 
|POLY 6             |     P=0.398      P=0.256N     P=0.529N     P=0.644     |P=0.260N     P=0.445      P=0.744      P=0.535N     | 
|LOGISTIC REGRESSION|     P=0.457      P=0.240N     P=0.509N     P=0.653N    |P=0.246N     P=0.446      P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.421      P=0.247N     P=0.508N     P=0.691N    |P=0.220N     P=0.500      P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    7/49 (14%)   6/47 (13%)   8/49 (16%)  |3/48 (6%)    0/49 (0%)    1/49 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     4/41.36      7/39.12      6/38.31      8/37.93     |3/42.67      0/38.70      1/41.00      2/37.93      | 
|POLY-3 PERCENT (g) |     9.7%         17.9%        15.7%        21.1%       |7.0%         0.0%         2.4%         5.3%         | 
|TERMINAL (d)       |     1/24 (4%)    6/22 (27%)   4/23 (17%)   4/21 (19%)  |2/28 (7%)    0/21 (0%)    0/28 (0%)    2/24 (8%)    | 
|FIRST INCIDENCE    |     639          695          681          562         |676          ---          671          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.139      P=0.214      P=0.329      P=0.120     |P=0.573      P=0.172N     P=0.337N     P=0.578N     | 
|POLY 3             |     P=0.151      P=0.226      P=0.320      P=0.133     |P=0.598N     P=0.137N     P=0.319N     P=0.554N     | 
|POLY 1.5           |     P=0.167      P=0.242      P=0.332      P=0.148     |P=0.601N     P=0.127N     P=0.311N     P=0.531N     | 
|POLY 6             |     P=0.136      P=0.205      P=0.302      P=0.119     |P=0.592N     P=0.150N     P=0.326N     P=0.578N     | 
|LOGISTIC REGRESSION|     P=0.131      P=0.215      P=0.316      P=0.140     |P=0.569      P=0.148N     P=0.313N     P=0.586N     | 
|COCH-ARM / FISHERS |     P=0.198      P=0.262      P=0.344      P=0.178     |P=0.602N     P=0.117N     P=0.301N     P=0.490N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    3/49 (6%)    1/47 (2%)    1/49 (2%)   |0/48 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.88      3/38.97      1/38.01      1/36.65     |0/42.45      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     2.5%         7.7%         2.6%         2.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    3/22 (14%)   1/23 (4%)    1/21 (5%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     692          733 (T)      733 (T)      733 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.435N     P=0.265      P=0.733      P=0.718     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.431N     P=0.287      P=0.745      P=0.736     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.418N     P=0.295      P=0.748      P=0.746     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.448N     P=0.276      P=0.739      P=0.725     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.447N     P=0.268      P=0.743      P=0.729     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.396N     P=0.309      P=0.742      P=0.753N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   10/49 (20%)  7/47 (15%)   8/49 (16%)  |3/48 (6%)    0/49 (0%)    1/49 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     5/41.52      10/39.12     7/38.31      8/37.93     |3/42.67      0/38.70      1/41.00      2/37.93      | 
|POLY-3 PERCENT (g) |     12.0%        25.6%        18.3%        21.1%       |7.0%         0.0%         2.4%         5.3%         | 
|TERMINAL (d)       |     1/24 (4%)    9/22 (41%)   5/23 (22%)   4/21 (19%)  |2/28 (7%)    0/21 (0%)    0/28 (0%)    2/24 (8%)    | 
|FIRST INCIDENCE    |     639          695          681          562         |676          ---          671          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.310      P=0.094      P=0.329      P=0.189     |P=0.573      P=0.172N     P=0.337N     P=0.578N     | 
|POLY 3             |     P=0.331      P=0.098      P=0.321      P=0.215     |P=0.598N     P=0.137N     P=0.319N     P=0.554N     | 
|POLY 1.5           |     P=0.359      P=0.112      P=0.335      P=0.237     |P=0.601N     P=0.127N     P=0.311N     P=0.531N     | 
|POLY 6             |     P=0.301      P=0.081      P=0.298      P=0.194     |P=0.592N     P=0.150N     P=0.326N     P=0.578N     | 
|LOGISTIC REGRESSION|     P=0.296      P=0.091      P=0.318      P=0.225     |P=0.569      P=0.148N     P=0.313N     P=0.586N     | 
|COCH-ARM / FISHERS |     P=0.409      P=0.131      P=0.350      P=0.276     |P=0.602N     P=0.117N     P=0.301N     P=0.490N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    0/49 (0%)    1/47 (2%)    1/49 (2%)   |4/49 (8%)    7/47 (15%)   4/49 (8%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     3/39.72      0/38.97      1/38.14      1/36.65     |4/43.24      7/38.71      4/41.18      2/38.47      | 
|POLY-3 PERCENT (g) |     7.6%         0.0%         2.6%         2.7%        |9.3%         18.1%        9.7%         5.2%         | 
|TERMINAL (d)       |     3/23 (13%)   0/22 (0%)    0/23 (0%)    1/21 (5%)   |4/28 (14%)   4/21 (19%)   3/28 (11%)   0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          728          733 (T)     |734 (T)      518          615          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.369N     P=0.127N     P=0.306N     P=0.336N    |P=0.161N     P=0.138      P=0.638      P=0.417N     | 
|POLY 3             |     P=0.350N     P=0.121N     P=0.319N     P=0.334N    |P=0.168N     P=0.198      P=0.617      P=0.392N     | 
|POLY 1.5           |     P=0.348N     P=0.119N     P=0.316N     P=0.320N    |P=0.157N     P=0.214      P=0.626      P=0.378N     | 
|POLY 6             |     P=0.351N     P=0.124N     P=0.324N     P=0.349N    |P=0.176N     P=0.181      P=0.611      P=0.405N     | 
|LOGISTIC REGRESSION|     P=0.374N     (e)          P=0.313N     P=0.336N    |P=0.155N     P=0.185      P=0.601      P=0.386N     | 
|COCH-ARM / FISHERS |     P=0.344N     P=0.117N     P=0.316N     P=0.301N    |P=0.135N     P=0.238      P=0.643N     P=0.349N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    1/49 (2%)    1/47 (2%)    1/49 (2%)   |0/49 (0%)    1/47 (2%)    1/49 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     3/40.40      1/39.12      1/38.64      1/37.34     |0/43.24      1/37.64      1/41.55      1/37.73      | 
|POLY-3 PERCENT (g) |     7.4%         2.6%         2.6%         2.7%        |0.0%         2.7%         2.4%         2.7%         | 
|TERMINAL (d)       |     1/23 (4%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    1/21 (5%)    0/28 (0%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     615          695          574          496         |---          734 (T)      440          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.342N     P=0.334N     P=0.359N    |P=0.389      P=0.443      P=0.500      P=0.469      | 
|POLY 3             |     P=0.271N     P=0.316N     P=0.321N     P=0.333N    |P=0.359      P=0.472      P=0.492      P=0.473      | 
|POLY 1.5           |     P=0.268N     P=0.308N     P=0.317N     P=0.320N    |P=0.373      P=0.480      P=0.495      P=0.481      | 
|POLY 6             |     P=0.275N     P=0.327N     P=0.328N     P=0.350N    |P=0.344      P=0.463      P=0.490      P=0.464      | 
|LOGISTIC REGRESSION|     P=0.218N     P=0.298N     P=0.307N     P=0.247N    |P=0.451      P=0.443      (e)          P=0.469      | 
|COCH-ARM / FISHERS |     P=0.261N     P=0.301N     P=0.316N     P=0.301N    |P=0.399      P=0.490      P=0.500      P=0.495      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/48 (13%)   1/49 (2%)    2/47 (4%)    2/49 (4%)   |4/49 (8%)    7/47 (15%)   5/49 (10%)   3/48 (6%)    | 
|POLY-3 RATE (b)    |     6/40.40      1/39.12      2/38.66      2/37.34     |4/43.24      7/38.71      5/41.97      3/38.47      | 
|POLY-3 PERCENT (g) |     14.9%        2.6%         5.2%         5.4%        |9.3%         18.1%        11.9%        7.8%         | 
|TERMINAL (d)       |     4/23 (17%)   0/22 (0%)    0/23 (0%)    1/21 (5%)   |4/28 (14%)   4/21 (19%)   3/28 (11%)   1/24 (4%)    | 
|FIRST INCIDENCE    |     615          695          574          496         |734 (T)      518          440          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.211N     P=0.074N     P=0.152N     P=0.177N    |P=0.304N     P=0.138      P=0.493      P=0.589N     | 
|POLY 3             |     P=0.176N     P=0.059N     P=0.145N     P=0.157N    |P=0.316N     P=0.198      P=0.481      P=0.564N     | 
|POLY 1.5           |     P=0.173N     P=0.056N     P=0.142N     P=0.145N    |P=0.301N     P=0.214      P=0.488      P=0.547N     | 
|POLY 6             |     P=0.178N     P=0.064N     P=0.150N     P=0.172N    |P=0.330N     P=0.181      P=0.478      P=0.579N     | 
|LOGISTIC REGRESSION|     P=0.176N     P=0.061N     P=0.143N     P=0.141N    |P=0.275N     P=0.185      P=0.506      P=0.572N     | 
|COCH-ARM / FISHERS |     P=0.170N     P=0.053N     P=0.141N     P=0.127N    |P=0.265N     P=0.238      P=0.500      P=0.512N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Schwannoma Benign                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/48 (4%)    0/49 (0%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.72      1/38.97      2/38.70      0/36.65     |0/43.24      0/38.70      1/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         5.2%         0.0%        |0.0%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    2/23 (9%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |---          ---          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.628N     P=0.483      P=0.228      (e)         |P=0.664      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.640N     P=0.491      P=0.225      (e)         |P=0.625      (e)          P=0.488      (e)          | 
|POLY 1.5           |     P=0.625N     P=0.495      P=0.229      (e)         |P=0.640      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.620      P=0.486      P=0.220      (e)         |P=0.610      (e)          P=0.485      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.483      P=0.228      (e)         |(e)          (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.601N     P=0.500      P=0.242      (e)         |P=0.669      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    5/49 (10%)   3/48 (6%)    2/49 (4%)   |1/49 (2%)    1/49 (2%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/41.10      5/39.18      3/39.67      2/36.65     |1/43.46      1/38.70      1/41.06      1/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         12.8%        7.6%         5.5%        |2.3%         2.6%         2.4%         2.6%         | 
|TERMINAL (d)       |     1/24 (4%)    4/22 (18%)   1/23 (4%)    2/21 (10%)  |0/28 (0%)    1/21 (5%)    0/28 (0%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     624          680          560          733 (T)     |677          734 (T)      653          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.435N     P=0.187      P=0.467      P=0.641     |P=0.597      P=0.708      P=0.731      P=0.719      | 
|POLY 3             |     P=0.432N     P=0.195      P=0.484      P=0.653     |P=0.592      P=0.734      P=0.748      P=0.730      | 
|POLY 1.5           |     P=0.410N     P=0.204      P=0.488      P=0.669     |P=0.604      P=0.746      P=0.753      P=0.741      | 
|POLY 6             |     P=0.458N     P=0.183      P=0.477      P=0.633     |P=0.580      P=0.719      P=0.745      P=0.717      | 
|LOGISTIC REGRESSION|     P=0.419N     P=0.188      P=0.499      P=0.647     |P=0.606      P=0.737      P=0.743N     P=0.734      | 
|COCH-ARM / FISHERS |     P=0.374N     P=0.218      P=0.490      P=0.691N    |P=0.630      P=0.753N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    4/49 (8%)    4/48 (8%)    4/49 (8%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/41.08      4/38.97      4/39.19      4/36.75     |1/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     9.7%         10.3%        10.2%        10.9%       |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/24 (8%)    4/22 (18%)   2/23 (9%)    3/21 (14%)  |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     677          733 (T)      650          707         |734 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.492      P=0.593      P=0.592      P=0.551     |P=0.336N     P=0.557N     P=0.500N     P=0.531N     | 
|POLY 3             |     P=0.504      P=0.615      P=0.618      P=0.582     |P=0.309N     P=0.522N     P=0.512N     P=0.526N     | 
|POLY 1.5           |     P=0.527      P=0.627      P=0.625      P=0.606     |P=0.318N     P=0.513N     P=0.507N     P=0.517N     | 
|POLY 6             |     P=0.477      P=0.596      P=0.607      P=0.553     |P=0.300N     P=0.534N     P=0.515N     P=0.535N     | 
|LOGISTIC REGRESSION|     P=0.475      P=0.592      P=0.610      P=0.548     |P=0.336N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.566      P=0.643N     P=0.631      P=0.643N    |P=0.331N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/49 (12%)   9/49 (18%)   7/48 (15%)   6/49 (12%)  |2/49 (4%)    1/49 (2%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     6/41.46      9/39.18      7/40.15      6/36.75     |2/43.46      1/38.70      1/41.06      1/37.93      | 
|POLY-3 PERCENT (g) |     14.5%        23.0%        17.4%        16.3%       |4.6%         2.6%         2.4%         2.6%         | 
|TERMINAL (d)       |     3/24 (13%)   8/22 (36%)   3/23 (13%)   5/21 (24%)  |1/28 (4%)    1/21 (5%)    0/28 (0%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     624          680          560          707         |677          734 (T)      653          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.516N     P=0.228      P=0.439      P=0.507     |P=0.454N     P=0.587N     P=0.530N     P=0.560N     | 
|POLY 3             |     P=0.504N     P=0.242      P=0.475      P=0.535     |P=0.437N     P=0.540N     P=0.520N     P=0.547N     | 
|POLY 1.5           |     P=0.470N     P=0.262      P=0.480      P=0.569     |P=0.433N     P=0.523N     P=0.513N     P=0.531N     | 
|POLY 6             |     P=0.546N     P=0.215      P=0.465      P=0.492     |P=0.440N     P=0.563N     P=0.526N     P=0.565N     | 
|LOGISTIC REGRESSION|     P=0.521N     P=0.225      P=0.477      P=0.505     |P=0.456N     P=0.564N     P=0.497N     P=0.562N     | 
|COCH-ARM / FISHERS |     P=0.415N     P=0.288      P=0.484      P=0.620N    |P=0.422N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    0/48 (0%)    3/49 (6%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/41.10      0/38.97      0/38.70      3/36.65     |0/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         8.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    3/21 (14%)  |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     624          ---          ---          733 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062      P=0.515N     P=0.526N     P=0.255     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.070      P=0.511N     P=0.512N     P=0.264     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.072      P=0.506N     P=0.508N     P=0.280     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.068      P=0.517N     P=0.518N     P=0.247     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.061      P=0.483N     P=0.499N     P=0.256     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.076      P=0.500N     P=0.505N     P=0.309     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    0/48 (0%)    4/49 (8%)   |0/49 (0%)    1/49 (2%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/41.10      0/38.97      0/38.70      4/37.00     |0/43.24      1/38.92      1/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         0.0%         10.8%       |0.0%         2.6%         2.5%         0.0%         | 
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    3/21 (14%)  |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     624          ---          ---          632         |---          677          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.068      P=0.258N     P=0.259N     P=0.271     |P=0.582N     P=0.465      P=0.500      (e)          | 
|POLY 3             |     P=0.080      P=0.249N     P=0.250N     P=0.289     |P=0.596N     P=0.479      P=0.488      (e)          | 
|POLY 1.5           |     P=0.082      P=0.244N     P=0.246N     P=0.307     |P=0.584N     P=0.488      P=0.493      (e)          | 
|POLY 6             |     P=0.079      P=0.256N     P=0.257N     P=0.269     |P=0.609N     P=0.468      P=0.485      (e)          | 
|LOGISTIC REGRESSION|     P=0.071      P=0.238N     P=0.242N     P=0.285     |P=0.583N     P=0.509      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.087      P=0.247N     P=0.253N     P=0.339     |P=0.562N     P=0.500      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    0/48 (0%)    4/49 (8%)   |0/49 (0%)    1/49 (2%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/41.10      0/38.97      0/38.70      4/37.00     |0/43.24      1/38.92      1/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         0.0%         10.8%       |0.0%         2.6%         2.5%         0.0%         | 
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    3/21 (14%)  |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     624          ---          ---          632         |---          677          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.068      P=0.258N     P=0.259N     P=0.271     |P=0.582N     P=0.465      P=0.500      (e)          | 
|POLY 3             |     P=0.080      P=0.249N     P=0.250N     P=0.289     |P=0.596N     P=0.479      P=0.488      (e)          | 
|POLY 1.5           |     P=0.082      P=0.244N     P=0.246N     P=0.307     |P=0.584N     P=0.488      P=0.493      (e)          | 
|POLY 6             |     P=0.079      P=0.256N     P=0.257N     P=0.269     |P=0.609N     P=0.468      P=0.485      (e)          | 
|LOGISTIC REGRESSION|     P=0.071      P=0.238N     P=0.242N     P=0.285     |P=0.583N     P=0.509      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.087      P=0.247N     P=0.253N     P=0.339     |P=0.562N     P=0.500      P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    1/48 (2%)    0/49 (0%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/40.72      0/38.97      1/38.70      0/36.65     |1/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         2.6%         0.0%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/24 (8%)    0/22 (0%)    1/23 (4%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      ---         |734 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241N     P=0.257N     P=0.515N     P=0.267N    |P=0.336N     P=0.557N     P=0.500N     P=0.531N     | 
|POLY 3             |     P=0.230N     P=0.247N     P=0.518N     P=0.261N    |P=0.309N     P=0.522N     P=0.512N     P=0.526N     | 
|POLY 1.5           |     P=0.228N     P=0.243N     P=0.512N     P=0.252N    |P=0.318N     P=0.513N     P=0.507N     P=0.517N     | 
|POLY 6             |     P=0.232N     P=0.252N     P=0.526N     P=0.271N    |P=0.300N     P=0.534N     P=0.515N     P=0.535N     | 
|LOGISTIC REGRESSION|     P=0.241N     (e)          P=0.515N     (e)         |P=0.336N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.224N     P=0.247N     P=0.508N     P=0.247N    |P=0.331N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    3/49 (6%)    0/48 (0%)    0/49 (0%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.72      3/39.44      0/38.70      0/36.65     |0/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     0.0%         7.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    2/22 (9%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          593          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.246N     P=0.110      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.242N     P=0.112      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.233N     P=0.115      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.252N     P=0.109      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.234N     P=0.116      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.224N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    3/49 (6%)    1/48 (2%)    0/49 (0%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/40.72      3/39.44      1/38.70      0/36.65     |1/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         7.6%         2.6%         0.0%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/24 (8%)    2/22 (9%)    1/23 (4%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      593          733 (T)      ---         |734 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.102N     P=0.464      P=0.515N     P=0.267N    |P=0.336N     P=0.557N     P=0.500N     P=0.531N     | 
|POLY 3             |     P=0.102N     P=0.485      P=0.518N     P=0.261N    |P=0.309N     P=0.522N     P=0.512N     P=0.526N     | 
|POLY 1.5           |     P=0.097N     P=0.491      P=0.512N     P=0.252N    |P=0.318N     P=0.513N     P=0.507N     P=0.517N     | 
|POLY 6             |     P=0.108N     P=0.478      P=0.526N     P=0.271N    |P=0.300N     P=0.534N     P=0.515N     P=0.535N     | 
|LOGISTIC REGRESSION|     P=0.105N     P=0.474      P=0.515N     (e)         |P=0.336N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.088N     P=0.500      P=0.508N     P=0.247N    |P=0.331N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    1/49 (2%)    0/49 (0%)   |3/49 (6%)    5/49 (10%)   3/49 (6%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     1/40.72      1/38.97      1/38.70      0/36.65     |3/43.24      5/40.17      3/41.44      3/39.01      | 
|POLY-3 PERCENT (g) |     2.5%         2.6%         2.6%         0.0%        |6.9%         12.5%        7.2%         7.7%         | 
|TERMINAL (d)       |     1/24 (4%)    1/22 (5%)    1/23 (4%)    0/21 (0%)   |3/28 (11%)   1/21 (5%)    1/28 (4%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      ---         |734 (T)      577          587          503          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327N     P=0.743      P=0.753      P=0.527N    |P=0.474N     P=0.248      P=0.654      P=0.593      | 
|POLY 3             |     P=0.327N     P=0.751      P=0.750      P=0.521N    |P=0.478N     P=0.315      P=0.643      P=0.614      | 
|POLY 1.5           |     P=0.320N     P=0.755      P=0.753      P=0.513N    |P=0.462N     P=0.332      P=0.649      P=0.630      | 
|POLY 6             |     P=0.335N     P=0.746      P=0.745      P=0.530N    |P=0.490N     P=0.297      P=0.641      P=0.600      | 
|LOGISTIC REGRESSION|     P=0.327N     P=0.743      P=0.753      (e)         |P=0.393N     P=0.370      P=0.647      P=0.663N     | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.753N     P=0.753N     P=0.500N    |P=0.428N     P=0.357      P=0.661N     P=0.661N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/49 (0%)    3/49 (6%)   |17/49 (35%)  20/49 (41%)  18/49 (37%)  14/49 (29%)  | 
|POLY-3 RATE (b)    |     0/40.72      0/38.97      0/38.70      3/36.65     |17/44.18     20/40.73     18/43.72     14/38.74     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         8.2%        |38.5%        49.1%        41.2%        36.1%        | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    3/21 (14%)  |12/28 (43%)  12/21 (57%)  10/28 (36%)  10/24 (42%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |625          581          440          625          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   (e)          (e)          P=0.096     |P=0.302N     P=0.084      P=0.454      P=0.562N     | 
|POLY 3             |     P=0.009 **   (e)          (e)          P=0.100     |P=0.319N     P=0.216      P=0.484      P=0.503N     | 
|POLY 1.5           |     P=0.009 **   (e)          (e)          P=0.107     |P=0.277N     P=0.264      P=0.486      P=0.441N     | 
|POLY 6             |     P=0.009 **   (e)          (e)          P=0.093     |P=0.361N     P=0.166      P=0.496      P=0.570N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.096     |P=0.322N     P=0.133      P=0.446      P=0.590      | 
|COCH-ARM / FISHERS |     P=0.011 *    (e)          (e)          P=0.121     |P=0.198N     P=0.339      P=0.500      P=0.332N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    1/49 (2%)    3/49 (6%)   |18/49 (37%)  24/49 (49%)  19/49 (39%)  17/49 (35%)  | 
|POLY-3 RATE (b)    |     1/40.72      1/38.97      1/38.70      3/36.65     |18/44.18     24/42.19     19/43.72     17/39.82     | 
|POLY-3 PERCENT (g) |     2.5%         2.6%         2.6%         8.2%        |40.7%        56.9%        43.5%        42.7%        | 
|TERMINAL (d)       |     1/24 (4%)    1/22 (5%)    1/23 (4%)    3/21 (14%)  |13/28 (46%)  12/21 (57%)  11/28 (39%)  11/24 (46%)  | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |625          577          440          503          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132      P=0.743      P=0.753      P=0.255     |P=0.380N     P=0.027 *    P=0.455      P=0.418      | 
|POLY 3             |     P=0.140      P=0.751      P=0.750      P=0.267     |P=0.379N     P=0.092      P=0.483      P=0.517      | 
|POLY 1.5           |     P=0.147      P=0.755      P=0.753      P=0.282     |P=0.337N     P=0.113      P=0.485      P=0.566      | 
|POLY 6             |     P=0.132      P=0.746      P=0.745      P=0.252     |P=0.417N     P=0.074      P=0.496      P=0.468      | 
|LOGISTIC REGRESSION|     P=0.132      P=0.743      P=0.753      P=0.255     |P=0.377N     P=0.056      P=0.434      P=0.427      | 
|COCH-ARM / FISHERS |     P=0.160      P=0.753N     P=0.753N     P=0.309     |P=0.252N     P=0.154      P=0.500      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    6/49 (12%)   8/48 (17%)   15/48 (31%) |0/49 (0%)    0/49 (0%)    4/49 (8%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/40.72      6/39.16      8/38.89      15/39.38    |0/43.24      0/38.70      4/40.82      2/38.50      | 
|POLY-3 PERCENT (g) |     0.0%         15.3%        20.6%        38.1%       |0.0%         0.0%         9.8%         5.2%         | 
|TERMINAL (d)       |     0/24 (0%)    5/22 (23%)   7/23 (30%)   7/21 (33%)  |0/28 (0%)    0/21 (0%)    3/28 (11%)   1/24 (4%)    | 
|FIRST INCIDENCE    |     ---          684          685          552         |---          ---          721          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.012 *    P=0.003 **   P<0.001 **  |P=0.078      (e)          P=0.063      P=0.208      | 
|POLY 3             |     P<0.001 **   P=0.013 *    P=0.003 **   P<0.001 **  |P=0.066      (e)          P=0.053      P=0.212      | 
|POLY 1.5           |     P<0.001 **   P=0.014 *    P=0.003 **   P<0.001 **  |P=0.071      (e)          P=0.056      P=0.220      | 
|POLY 6             |     P<0.001 **   P=0.011 *    P=0.002 **   P<0.001 **  |P=0.062      (e)          P=0.050      P=0.204      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.011 *    P=0.003 **   P<0.001 **  |P=0.073      (e)          P=0.054      P=0.262      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.013 *    P=0.003 **   P<0.001 **  |P=0.087      (e)          P=0.059      P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Neuroblastoma                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    4/48 (8%)    3/48 (6%)   |0/49 (0%)    2/49 (4%)    3/49 (6%)    12/49 (24%)  | 
|POLY-3 RATE (b)    |     0/40.72      0/38.97      4/39.71      3/38.79     |0/43.24      2/38.96      3/41.86      12/42.52     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         10.1%        7.7%        |0.0%         5.1%         7.2%         28.2%        | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    2/23 (9%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    1/28 (4%)    3/24 (13%)   | 
|FIRST INCIDENCE    |     ---          ---          433          399         |---          679          480          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    (e)          P=0.060      P=0.119     |P<0.001 **   P=0.185      P=0.114      P<0.001 **   | 
|POLY 3             |     P=0.027 *    (e)          P=0.056      P=0.109     |P<0.001 **   P=0.214      P=0.112      P<0.001 **   | 
|POLY 1.5           |     P=0.028 *    (e)          P=0.057      P=0.112     |P<0.001 **   P=0.224      P=0.115      P<0.001 **   | 
|POLY 6             |     P=0.026 *    (e)          P=0.054      P=0.106     |P<0.001 **   P=0.203      P=0.111      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.051      (e)          P=0.062      P=0.201     |P<0.001 **   P=0.213      P=0.178      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.030 *    (e)          P=0.056      P=0.117     |P<0.001 **   P=0.247      P=0.121      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor Malignant                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    2/49 (4%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/43.46      2/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |                                                        |4.6%         5.2%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |1/28 (4%)    2/21 (10%)   0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |                                                        |677          734 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.083N     P=0.598      P=0.252N     P=0.281N     | 
|POLY 3             |                                                        |P=0.082N     P=0.652      P=0.251N     P=0.269N     | 
|POLY 1.5           |                                                        |P=0.080N     P=0.670      P=0.246N     P=0.257N     | 
|POLY 6             |                                                        |P=0.084N     P=0.627      P=0.257N     P=0.281N     | 
|LOGISTIC REGRESSION|                                                        |P=0.088N     P=0.620      P=0.248N     P=0.266N     | 
|COCH-ARM / FISHERS |                                                        |P=0.076N     P=0.691N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    0/48 (0%)    2/49 (4%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.72      0/38.97      0/38.70      2/36.65     |0/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         5.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    2/21 (10%)  |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          733 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200      P=0.517N     P=0.508N     P=0.453     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.214      P=0.509N     P=0.510N     P=0.463     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.217      P=0.505N     P=0.507N     P=0.477     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.211      P=0.514N     P=0.515N     P=0.448     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.200      (e)          (e)          P=0.453     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.223      P=0.500N     P=0.505N     P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    0/48 (0%)    3/49 (6%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.72      0/38.97      0/38.70      3/36.92     |0/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         8.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    2/21 (10%)  |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          660         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061      P=0.517N     P=0.508N     P=0.252     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.070      P=0.509N     P=0.510N     P=0.270     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.072      P=0.505N     P=0.507N     P=0.283     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.069      P=0.514N     P=0.515N     P=0.257     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.059      (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.076      P=0.500N     P=0.505N     P=0.309     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/49 (63%)  31/49 (63%)  35/47 (74%)  29/49 (59%) |23/49 (47%)  27/49 (55%)  24/49 (49%)  20/48 (42%)  | 
|POLY-3 RATE (b)    |     31/45.41     31/45.26     35/44.33     29/43.25    |23/46.45     27/44.09     24/44.27     20/41.56     | 
|POLY-3 PERCENT (g) |     68.3%        68.5%        79.0%        67.1%       |49.5%        61.2%        54.2%        48.1%        | 
|TERMINAL (d)       |     15/24 (63%)  17/22 (77%)  17/23 (74%)  12/21 (57%) |12/28 (43%)  14/21 (67%)  14/28 (50%)  11/24 (46%)  | 
|FIRST INCIDENCE    |     516          390          489          469         |509          509          581          482          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.374      P=0.415      P=0.222      P=0.409     |P=0.340N     P=0.070      P=0.429      P=0.520      | 
|POLY 3             |     P=0.517      P=0.583      P=0.173      P=0.543N    |P=0.335N     P=0.176      P=0.405      P=0.534N     | 
|POLY 1.5           |     P=0.529N     P=0.581N     P=0.173      P=0.501N    |P=0.293N     P=0.211      P=0.437      P=0.481N     | 
|POLY 6             |     P=0.494      P=0.529      P=0.163      P=0.587N    |P=0.386N     P=0.140      P=0.386      P=0.581      | 
|LOGISTIC REGRESSION|     P=0.495N     P=0.568      P=0.158      P=0.520N    |P=0.239N     P=0.288      P=0.487      P=0.401N     | 
|COCH-ARM / FISHERS |     P=0.426N     P=0.583N     P=0.168      P=0.418N    |P=0.211N     P=0.272      P=0.500      P=0.375N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/49 (63%)  31/49 (63%)  35/47 (74%)  29/49 (59%) |23/49 (47%)  27/49 (55%)  25/49 (51%)  20/48 (42%)  | 
|POLY-3 RATE (b)    |     31/45.41     31/45.26     35/44.33     29/43.25    |23/46.45     27/44.09     25/44.32     20/41.56     | 
|POLY-3 PERCENT (g) |     68.3%        68.5%        79.0%        67.1%       |49.5%        61.2%        56.4%        48.1%        | 
|TERMINAL (d)       |     15/24 (63%)  17/22 (77%)  17/23 (74%)  12/21 (57%) |12/28 (43%)  14/21 (67%)  14/28 (50%)  11/24 (46%)  | 
|FIRST INCIDENCE    |     516          390          489          469         |509          509          581          482          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.374      P=0.415      P=0.222      P=0.409     |P=0.353N     P=0.070      P=0.365      P=0.520      | 
|POLY 3             |     P=0.517      P=0.583      P=0.173      P=0.543N    |P=0.351N     P=0.176      P=0.325      P=0.534N     | 
|POLY 1.5           |     P=0.529N     P=0.581N     P=0.173      P=0.501N    |P=0.307N     P=0.211      P=0.356      P=0.481N     | 
|POLY 6             |     P=0.494      P=0.529      P=0.163      P=0.587N    |P=0.404N     P=0.140      P=0.308      P=0.581      | 
|LOGISTIC REGRESSION|     P=0.495N     P=0.568      P=0.158      P=0.520N    |P=0.252N     P=0.288      P=0.402      P=0.401N     | 
|COCH-ARM / FISHERS |     P=0.426N     P=0.583N     P=0.168      P=0.418N    |P=0.220N     P=0.272      P=0.420      P=0.375N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/49 (4%)    0/49 (0%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.72      1/39.17      2/38.90      0/36.65     |0/43.24      0/38.70      1/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         5.1%         0.0%        |0.0%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    1/23 (4%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          681          681          ---         |---          ---          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.635N     P=0.487      P=0.228      (e)         |P=0.664      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.640N     P=0.492      P=0.227      (e)         |P=0.625      (e)          P=0.488      (e)          | 
|POLY 1.5           |     P=0.625N     P=0.495      P=0.230      (e)         |P=0.640      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.621      P=0.488      P=0.222      (e)         |P=0.610      (e)          P=0.485      (e)          | 
|LOGISTIC REGRESSION|     P=0.627N     P=0.498      P=0.222      (e)         |(e)          (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.600N     P=0.500      P=0.247      (e)         |P=0.669      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    5/49 (10%)   4/49 (8%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/40.98      5/39.91      4/39.10      2/37.04     |1/43.24      0/38.70      1/40.77      1/38.13      | 
|POLY-3 PERCENT (g) |     9.8%         12.5%        10.2%        5.4%        |2.3%         0.0%         2.5%         2.6%         | 
|TERMINAL (d)       |     2/24 (8%)    2/22 (9%)    2/23 (9%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     692          567          681          659         |734 (T)      ---          734 (T)      680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.272N     P=0.440      P=0.596      P=0.427N    |P=0.486      P=0.557N     P=0.762      P=0.722      | 
|POLY 3             |     P=0.251N     P=0.483      P=0.618      P=0.384N    |P=0.479      P=0.522N     P=0.748      P=0.732      | 
|POLY 1.5           |     P=0.235N     P=0.490      P=0.625      P=0.367N    |P=0.485      P=0.513N     P=0.752      P=0.742      | 
|POLY 6             |     P=0.269N     P=0.475      P=0.608      P=0.403N    |P=0.475      P=0.534N     P=0.744      P=0.722      | 
|LOGISTIC REGRESSION|     P=0.246N     P=0.476      P=0.602      P=0.398N    |P=0.468      (e)          P=0.762      P=0.732      | 
|COCH-ARM / FISHERS |     P=0.206N     P=0.500      P=0.643N     P=0.339N    |P=0.500      P=0.500N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   2/49 (4%)    2/49 (4%)    2/49 (4%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     5/41.47      2/38.97      2/38.70      2/36.65     |0/43.24      0/38.70      1/41.15      1/37.93      | 
|POLY-3 PERCENT (g) |     12.1%        5.1%         5.2%         5.5%        |0.0%         0.0%         2.4%         2.6%         | 
|TERMINAL (d)       |     4/24 (17%)   2/22 (9%)    2/23 (9%)    2/21 (10%)  |0/28 (0%)    0/21 (0%)    0/28 (0%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     460          733 (T)      733 (T)      733 (T)     |---          ---          624          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.247N     P=0.231N     P=0.266N    |P=0.208      (e)          P=0.476      P=0.469      | 
|POLY 3             |     P=0.233N     P=0.240N     P=0.243N     P=0.268N    |P=0.195      (e)          P=0.490      P=0.474      | 
|POLY 1.5           |     P=0.224N     P=0.230N     P=0.235N     P=0.248N    |P=0.203      (e)          P=0.494      P=0.483      | 
|POLY 6             |     P=0.242N     P=0.253N     P=0.256N     P=0.290N    |P=0.187      (e)          P=0.488      P=0.465      | 
|LOGISTIC REGRESSION|     P=0.254N     P=0.230N     P=0.233N     P=0.255N    |P=0.215      (e)          P=0.567      P=0.469      | 
|COCH-ARM / FISHERS |     P=0.208N     P=0.218N     P=0.218N     P=0.218N    |P=0.219      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   5/49 (10%)   4/49 (8%)    4/49 (8%)   |1/49 (2%)    0/49 (0%)    1/49 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     7/41.68      5/39.24      4/38.70      4/37.61     |1/43.24      0/38.70      1/41.15      2/38.12      | 
|POLY-3 PERCENT (g) |     16.8%        12.7%        10.3%        10.6%       |2.3%         0.0%         2.4%         5.3%         | 
|TERMINAL (d)       |     5/24 (21%)   3/22 (14%)   4/23 (17%)   2/21 (10%)  |1/28 (4%)    0/21 (0%)    0/28 (0%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     460          684          733 (T)      575         |734 (T)      ---          624          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.283N     P=0.441N     P=0.285N     P=0.348N    |P=0.204      P=0.557N     P=0.747      P=0.439      | 
|POLY 3             |     P=0.258N     P=0.421N     P=0.302N     P=0.320N    |P=0.207      P=0.522N     P=0.750      P=0.456      | 
|POLY 1.5           |     P=0.246N     P=0.404N     P=0.289N     P=0.299N    |P=0.210      P=0.513N     P=0.753      P=0.471      | 
|POLY 6             |     P=0.272N     P=0.442N     P=0.324N     P=0.343N    |P=0.205      P=0.534N     P=0.747      P=0.441      | 
|LOGISTIC REGRESSION|     P=0.273N     P=0.411N     P=0.294N     P=0.282N    |P=0.203      (e)          P=0.755N     P=0.435      | 
|COCH-ARM / FISHERS |     P=0.220N     P=0.380N     P=0.262N     P=0.262N    |P=0.220      P=0.500N     P=0.753N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/49 (4%)    0/49 (0%)    2/49 (4%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/40.93      2/39.24      0/38.70      2/37.61     |0/43.24      0/38.70      0/40.77      1/38.12      | 
|POLY-3 PERCENT (g) |     4.9%         5.1%         0.0%         5.3%        |0.0%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     678          684          ---          575         |---          ---          ---          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.591N     P=0.658      P=0.255N     P=0.632     |P=0.177      (e)          (e)          P=0.455      | 
|POLY 3             |     P=0.551N     P=0.679      P=0.249N     P=0.664     |P=0.181      (e)          (e)          P=0.475      | 
|POLY 1.5           |     P=0.546N     P=0.685      P=0.246N     P=0.674     |P=0.184      (e)          (e)          P=0.483      | 
|POLY 6             |     P=0.558N     P=0.672      P=0.256N     P=0.653     |P=0.178      (e)          (e)          P=0.467      | 
|LOGISTIC REGRESSION|     P=0.535N     P=0.678      P=0.251N     P=0.675N    |P=0.185      (e)          (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.536N     P=0.691N     P=0.247N     P=0.691N    |P=0.191      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    3/49 (6%)    2/49 (4%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/40.93      3/39.24      2/38.70      2/37.61     |1/43.24      0/38.70      0/40.77      1/38.12      | 
|POLY-3 PERCENT (g) |     4.9%         7.7%         5.2%         5.3%        |2.3%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     1/24 (4%)    1/22 (5%)    2/23 (9%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     678          684          733 (T)      575         |734 (T)      ---          ---          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.562N     P=0.459      P=0.674      P=0.632     |P=0.545      P=0.557N     P=0.500N     P=0.718      | 
|POLY 3             |     P=0.535N     P=0.481      P=0.674      P=0.664     |P=0.557      P=0.522N     P=0.512N     P=0.732      | 
|POLY 1.5           |     P=0.523N     P=0.489      P=0.681      P=0.674     |P=0.557      P=0.513N     P=0.507N     P=0.742      | 
|POLY 6             |     P=0.548N     P=0.470      P=0.664      P=0.653     |P=0.558      P=0.534N     P=0.515N     P=0.722      | 
|LOGISTIC REGRESSION|     P=0.531N     P=0.471      P=0.663      P=0.675N    |P=0.539      (e)          (e)          P=0.730      | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.691N     P=0.691N    |P=0.562      P=0.500N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    3/49 (6%)    2/49 (4%)    2/49 (4%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/40.98      3/39.51      2/38.90      2/37.04     |0/43.24      0/38.70      0/40.77      1/38.13      | 
|POLY-3 PERCENT (g) |     9.8%         7.6%         5.1%         5.4%        |0.0%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     2/24 (8%)    2/22 (9%)    1/23 (4%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     692          567          681          659         |---          ---          ---          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.561N     P=0.382N     P=0.427N    |P=0.182      (e)          (e)          P=0.462      | 
|POLY 3             |     P=0.280N     P=0.520N     P=0.360N     P=0.384N    |P=0.181      (e)          (e)          P=0.475      | 
|POLY 1.5           |     P=0.270N     P=0.511N     P=0.354N     P=0.367N    |P=0.184      (e)          (e)          P=0.483      | 
|POLY 6             |     P=0.291N     P=0.533N     P=0.372N     P=0.403N    |P=0.178      (e)          (e)          P=0.467      | 
|LOGISTIC REGRESSION|     P=0.288N     P=0.525N     P=0.373N     P=0.398N    |P=0.187      (e)          (e)          P=0.498      | 
|COCH-ARM / FISHERS |     P=0.249N     P=0.500N     P=0.339N     P=0.339N    |P=0.191      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    3/49 (6%)    0/49 (0%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.81      1/38.97      3/38.79      0/36.65     |0/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     2.5%         2.6%         7.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    2/23 (9%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     709          733 (T)      710          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.461N     P=0.733      P=0.284      P=0.539N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.467N     P=0.751      P=0.286      P=0.521N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.450N     P=0.755      P=0.292      P=0.513N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.486N     P=0.745      P=0.277      P=0.531N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.472N     P=0.742      P=0.270      P=0.529N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.422N     P=0.753N     P=0.309      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/49 (4%)    0/49 (0%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.72      1/38.97      2/38.70      0/36.65     |1/43.24      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         5.2%         0.0%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    2/23 (9%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |734 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.628N     P=0.483      P=0.228      (e)         |P=0.336N     P=0.557N     P=0.500N     P=0.531N     | 
|POLY 3             |     P=0.639N     P=0.491      P=0.225      (e)         |P=0.309N     P=0.522N     P=0.512N     P=0.526N     | 
|POLY 1.5           |     P=0.625N     P=0.495      P=0.229      (e)         |P=0.318N     P=0.513N     P=0.507N     P=0.517N     | 
|POLY 6             |     P=0.622      P=0.486      P=0.220      (e)         |P=0.300N     P=0.534N     P=0.515N     P=0.535N     | 
|LOGISTIC REGRESSION|     (e)          P=0.483      P=0.228      (e)         |P=0.336N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.600N     P=0.500      P=0.247      (e)         |P=0.331N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    4/49 (8%)    2/49 (4%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/40.98      4/39.71      2/38.90      2/37.04     |1/43.24      0/38.70      0/40.77      1/38.13      | 
|POLY-3 PERCENT (g) |     9.8%         10.1%        5.1%         5.4%        |2.3%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     2/24 (8%)    2/22 (9%)    1/23 (4%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     692          567          681          659         |734 (T)      ---          ---          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256N     P=0.584      P=0.382N     P=0.427N    |P=0.549      P=0.557N     P=0.500N     P=0.722      | 
|POLY 3             |     P=0.230N     P=0.627      P=0.360N     P=0.384N    |P=0.557      P=0.522N     P=0.512N     P=0.732      | 
|POLY 1.5           |     P=0.219N     P=0.634      P=0.354N     P=0.367N    |P=0.557      P=0.513N     P=0.507N     P=0.742      | 
|POLY 6             |     P=0.242N     P=0.618      P=0.372N     P=0.403N    |P=0.559      P=0.534N     P=0.515N     P=0.722      | 
|LOGISTIC REGRESSION|     P=0.233N     P=0.622      P=0.373N     P=0.398N    |P=0.540      (e)          (e)          P=0.732      | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.643N     P=0.339N     P=0.339N    |P=0.562      P=0.500N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    3/49 (6%)    2/49 (4%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/40.98      3/39.51      2/38.90      2/37.04     |1/43.24      0/38.70      0/40.77      1/38.13      | 
|POLY-3 PERCENT (g) |     9.8%         7.6%         5.1%         5.4%        |2.3%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     2/24 (8%)    2/22 (9%)    1/23 (4%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     692          567          681          659         |734 (T)      ---          ---          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.561N     P=0.382N     P=0.427N    |P=0.549      P=0.557N     P=0.500N     P=0.722      | 
|POLY 3             |     P=0.280N     P=0.520N     P=0.360N     P=0.384N    |P=0.557      P=0.522N     P=0.512N     P=0.732      | 
|POLY 1.5           |     P=0.270N     P=0.511N     P=0.354N     P=0.367N    |P=0.557      P=0.513N     P=0.507N     P=0.742      | 
|POLY 6             |     P=0.291N     P=0.533N     P=0.372N     P=0.403N    |P=0.559      P=0.534N     P=0.515N     P=0.722      | 
|LOGISTIC REGRESSION|     P=0.288N     P=0.525N     P=0.373N     P=0.398N    |P=0.540      (e)          (e)          P=0.732      | 
|COCH-ARM / FISHERS |     P=0.249N     P=0.500N     P=0.339N     P=0.339N    |P=0.562      P=0.500N     P=0.500N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/49 (78%)  32/49 (65%)  36/48 (75%)  31/49 (63%) |                                                    | 
|POLY-3 RATE (b)    |     38/44.45     32/43.09     36/43.13     31/40.84    |                                                    | 
|POLY-3 PERCENT (g) |     85.5%        74.3%        83.5%        75.9%       |                                                    | 
|TERMINAL (d)       |     24/24 (100%) 17/22 (77%)  20/23 (87%)  18/21 (86%) |                                                    | 
|FIRST INCIDENCE    |     460          520          560          399         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490N     P=0.361N     P=0.542      P=0.430N    |                                                    | 
|POLY 3             |     P=0.284N     P=0.120N     P=0.516N     P=0.162N    |                                                    | 
|POLY 1.5           |     P=0.226N     P=0.128N     P=0.502N     P=0.130N    |                                                    | 
|POLY 6             |     P=0.373N     P=0.100N     P=0.509N     P=0.214N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.405N     P=0.183N     P=0.590N     P=0.281N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.159N     P=0.132N     P=0.477N     P=0.092N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/46 (20%)   6/47 (13%)   4/45 (9%)    4/47 (9%)   |4/47 (9%)    4/46 (9%)    2/48 (4%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     9/39.52      6/39.17      4/37.68      4/36.20     |4/42.47      4/37.19      2/39.88      1/36.99      | 
|POLY-3 PERCENT (g) |     22.8%        15.3%        10.6%        11.1%       |9.4%         10.8%        5.0%         2.7%         | 
|TERMINAL (d)       |     7/24 (29%)   4/22 (18%)   0/22 (0%)    2/20 (10%)  |1/28 (4%)    3/21 (14%)   2/28 (7%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     460          551          615          632         |602          677          734 (T)      734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.148N     P=0.342N     P=0.163N     P=0.197N    |P=0.105N     P=0.507      P=0.362N     P=0.241N     | 
|POLY 3             |     P=0.106N     P=0.289N     P=0.129N     P=0.146N    |P=0.106N     P=0.569      P=0.366N     P=0.223N     | 
|POLY 1.5           |     P=0.097N     P=0.282N     P=0.126N     P=0.128N    |P=0.097N     P=0.595      P=0.351N     P=0.204N     | 
|POLY 6             |     P=0.117N     P=0.299N     P=0.131N     P=0.168N    |P=0.118N     P=0.536      P=0.383N     P=0.247N     | 
|LOGISTIC REGRESSION|     P=0.096N     P=0.279N     P=0.125N     P=0.137N    |P=0.106N     P=0.593      P=0.340N     P=0.190N     | 
|COCH-ARM / FISHERS |     P=0.085N     P=0.272N     P=0.124N     P=0.107N    |P=0.081N     P=0.631      P=0.329N     P=0.174N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/46 (2%)    2/47 (4%)    1/45 (2%)    1/47 (2%)   |3/47 (6%)    2/46 (4%)    2/48 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/38.43      2/38.51      1/36.67      1/35.61     |3/41.89      2/36.97      2/39.88      0/36.99      | 
|POLY-3 PERCENT (g) |     2.6%         5.2%         2.7%         2.8%        |7.2%         5.4%         5.0%         0.0%         | 
|TERMINAL (d)       |     1/24 (4%)    1/22 (5%)    1/22 (5%)    1/20 (5%)   |2/28 (7%)    2/21 (10%)   2/28 (7%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      643          733 (T)      733 (T)     |690          734 (T)      734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.558N     P=0.480      P=0.743      P=0.722     |P=0.097N     P=0.628N     P=0.506N     P=0.159N     | 
|POLY 3             |     P=0.524N     P=0.501      P=0.751      P=0.744     |P=0.102N     P=0.557N     P=0.523N     P=0.142N     | 
|POLY 1.5           |     P=0.512N     P=0.504      P=0.753      P=0.753     |P=0.096N     P=0.537N     P=0.510N     P=0.132N     | 
|POLY 6             |     P=0.540N     P=0.496      P=0.746      P=0.731     |P=0.108N     P=0.581N     P=0.535N     P=0.154N     | 
|LOGISTIC REGRESSION|     P=0.550N     P=0.496      P=0.743      P=0.722     |P=0.107N     P=0.599N     P=0.532N     P=0.154N     | 
|COCH-ARM / FISHERS |     P=0.497N     P=0.508      P=0.747      P=0.747N    |P=0.084N     P=0.510N     P=0.490N     P=0.117N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/46 (22%)  8/47 (17%)   5/45 (11%)   5/47 (11%)  |7/47 (15%)   6/46 (13%)   4/48 (8%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     10/39.52     8/39.50      5/37.68      5/36.20     |7/42.64      6/37.19      4/39.88      1/36.99      | 
|POLY-3 PERCENT (g) |     25.3%        20.3%        13.3%        13.8%       |16.4%        16.1%        10.0%        2.7%         | 
|TERMINAL (d)       |     8/24 (33%)   5/22 (23%)   1/22 (5%)    3/20 (15%)  |3/28 (11%)   5/21 (24%)   4/28 (14%)   1/24 (4%)    | 
|FIRST INCIDENCE    |     460          551          615          632         |602          677          734 (T)      734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.151N     P=0.463N     P=0.182N     P=0.223N    |P=0.023N*    P=0.540      P=0.284N     P=0.062N     | 
|POLY 3             |     P=0.107N     P=0.394N     P=0.145N     P=0.165N    |P=0.024N*    P=0.606N     P=0.299N     P=0.047N*    | 
|POLY 1.5           |     P=0.095N     P=0.388N     P=0.142N     P=0.145N    |P=0.020N*    P=0.568N     P=0.278N     P=0.039N*    | 
|POLY 6             |     P=0.121N     P=0.403N     P=0.148N     P=0.192N    |P=0.029N*    P=0.586      P=0.323N     P=0.058N     | 
|LOGISTIC REGRESSION|     P=0.100N     P=0.390N     P=0.144N     P=0.165N    |P=0.025N*    P=0.612N     P=0.289N     P=0.043N*    | 
|COCH-ARM / FISHERS |     P=0.081N     P=0.377N     P=0.139N     P=0.120N    |P=0.015N*    P=0.517N     P=0.249N     P=0.027N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Papilloma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/49 (0%)    0/48 (0%)    2/49 (4%)   |1/48 (2%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/39.72      0/38.97      0/38.70      2/36.65     |1/42.63      0/38.70      1/40.88      0/37.93      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         5.5%        |2.4%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     1/23 (4%)    0/22 (0%)    0/23 (0%)    2/21 (10%)  |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          733 (T)     |734 (T)      ---          707          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.206      P=0.509N     P=0.500N     P=0.468     |P=0.454N     P=0.557N     P=0.757      P=0.531N     | 
|POLY 3             |     P=0.217      P=0.504N     P=0.505N     P=0.472     |P=0.441N     P=0.519N     P=0.751      P=0.523N     | 
|POLY 1.5           |     P=0.220      P=0.500N     P=0.503N     P=0.485     |P=0.440N     P=0.509N     P=0.756      P=0.514N     | 
|POLY 6             |     P=0.214      P=0.508N     P=0.509N     P=0.457     |P=0.440N     P=0.532N     P=0.747      P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.206      (e)          (e)          P=0.468     |P=0.463N     (e)          P=0.747      (e)          | 
|COCH-ARM / FISHERS |     P=0.226      P=0.495N     P=0.500N     P=0.508     |P=0.435N     P=0.495N     P=0.747N     P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |15/49 (31%)  7/49 (14%)   9/49 (18%)   7/49 (14%)   | 
|POLY-3 RATE (b)    |                                                        |15/45.34     7/39.36      9/41.98      7/38.18      | 
|POLY-3 PERCENT (g) |                                                        |33.1%        17.8%        21.4%        18.3%        | 
|TERMINAL (d)       |                                                        |9/28 (32%)   4/21 (19%)   7/28 (25%)   6/24 (25%)   | 
|FIRST INCIDENCE    |                                                        |519          635          480          667          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.118N     P=0.157N     P=0.148N     P=0.114N     | 
|POLY 3             |                                                        |P=0.118N     P=0.085N     P=0.162N     P=0.099N     | 
|POLY 1.5           |                                                        |P=0.105N     P=0.064N     P=0.144N     P=0.074N     | 
|POLY 6             |                                                        |P=0.135N     P=0.120N     P=0.185N     P=0.136N     | 
|LOGISTIC REGRESSION|                                                        |P=0.120N     P=0.064N     P=0.119N     P=0.080N     | 
|COCH-ARM / FISHERS |                                                        |P=0.084N     P=0.044N*    P=0.120N     P=0.044N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    1/49 (2%)    1/49 (2%)   |2/49 (4%)    1/49 (2%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.72      0/38.97      1/38.70      1/36.83     |2/43.72      1/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.6%         2.7%        |4.6%         2.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    1/23 (4%)    0/21 (0%)   |0/28 (0%)    1/21 (5%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          733 (T)      685         |657          734 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203      (e)          P=0.492      P=0.466     |P=0.118N     P=0.597N     P=0.269N     P=0.302N     | 
|POLY 3             |     P=0.197      (e)          P=0.490      P=0.480     |P=0.102N     P=0.542N     P=0.253N     P=0.270N     | 
|POLY 1.5           |     P=0.205      (e)          P=0.493      P=0.487     |P=0.102N     P=0.524N     P=0.247N     P=0.258N     | 
|POLY 6             |     P=0.189      (e)          P=0.485      P=0.472     |P=0.102N     P=0.566N     P=0.259N     P=0.284N     | 
|LOGISTIC REGRESSION|     P=0.196      (e)          P=0.492      P=0.486     |P=0.107N     P=0.515N     P=0.215N     P=0.222N     | 
|COCH-ARM / FISHERS |     P=0.219      (e)          P=0.500      P=0.500     |P=0.102N     P=0.500N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    0/49 (0%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.72      1/39.12      0/38.70      2/37.61     |1/43.46      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         0.0%         5.3%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    1/21 (5%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          695          ---          245         |677          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.142      P=0.465      (e)          P=0.225     |P=0.351N     P=0.535N     P=0.523N     P=0.542N     | 
|POLY 3             |     P=0.142      P=0.492      (e)          P=0.219     |P=0.309N     P=0.523N     P=0.513N     P=0.527N     | 
|POLY 1.5           |     P=0.147      P=0.495      (e)          P=0.227     |P=0.317N     P=0.513N     P=0.508N     P=0.518N     | 
|POLY 6             |     P=0.137      P=0.488      (e)          P=0.211     |P=0.299N     P=0.536N     P=0.517N     P=0.537N     | 
|LOGISTIC REGRESSION|     P=0.195      P=0.493      (e)          P=0.395     |P=0.329N     P=0.491N     P=0.489N     P=0.499N     | 
|COCH-ARM / FISHERS |     P=0.155      P=0.500      (e)          P=0.247     |P=0.331N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    0/49 (0%)    2/49 (4%)   |2/49 (4%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.72      1/39.12      0/38.70      2/37.61     |2/43.49      0/38.70      0/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         0.0%         5.3%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    1/21 (5%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          695          ---          245         |677          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.142      P=0.465      (e)          P=0.225     |P=0.154N     P=0.295N     P=0.260N     P=0.288N     | 
|POLY 3             |     P=0.142      P=0.492      (e)          P=0.219     |P=0.124N     P=0.264N     P=0.252N     P=0.269N     | 
|POLY 1.5           |     P=0.147      P=0.495      (e)          P=0.227     |P=0.129N     P=0.252N     P=0.246N     P=0.257N     | 
|POLY 6             |     P=0.137      P=0.488      (e)          P=0.211     |P=0.118N     P=0.280N     P=0.257N     P=0.282N     | 
|LOGISTIC REGRESSION|     P=0.195      P=0.493      (e)          P=0.395     |P=0.147N     P=0.256N     P=0.244N     P=0.260N     | 
|COCH-ARM / FISHERS |     P=0.155      P=0.500      (e)          P=0.247     |P=0.139N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/49 (53%)  21/49 (43%)  24/49 (49%)  17/49 (35%) |16/49 (33%)  21/49 (43%)  15/49 (31%)  15/49 (31%)  | 
|POLY-3 RATE (b)    |     26/44.86     21/43.44     24/44.17     17/39.11    |16/46.21     21/43.57     15/42.72     15/41.19     | 
|POLY-3 PERCENT (g) |     58.0%        48.4%        54.3%        43.5%       |34.6%        48.2%        35.1%        36.4%        | 
|TERMINAL (d)       |     12/24 (50%)  6/22 (27%)   7/23 (30%)   7/21 (33%)  |3/28 (11%)   7/21 (33%)   8/28 (29%)   6/24 (25%)   | 
|FIRST INCIDENCE    |     469          502          560          527         |572          471          587          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250N     P=0.362N     P=0.539N     P=0.213N    |P=0.418N     P=0.083      P=0.568      P=0.417      | 
|POLY 3             |     P=0.168N     P=0.240N     P=0.447N     P=0.127N    |P=0.398N     P=0.134      P=0.569      P=0.519      | 
|POLY 1.5           |     P=0.124N     P=0.229N     P=0.455N     P=0.090N    |P=0.347N     P=0.161      P=0.565N     P=0.571      | 
|POLY 6             |     P=0.224N     P=0.249N     P=0.429N     P=0.181N    |P=0.456N     P=0.105      P=0.524      P=0.462      | 
|LOGISTIC REGRESSION|     P=0.096N     P=0.217N     P=0.441N     P=0.091N    |P=0.255N     P=0.290      P=0.496N     P=0.486N     | 
|COCH-ARM / FISHERS |     P=0.070N     P=0.209N     P=0.420N     P=0.051N    |P=0.256N     P=0.202      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    1/49 (2%)    1/49 (2%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/40.72      0/38.97      1/39.41      1/36.65     |0/43.24      0/38.70      1/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         2.5%         2.7%        |0.0%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     2/24 (8%)    0/22 (0%)    0/23 (0%)    1/21 (5%)   |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          489          733 (T)     |---          ---          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570N     P=0.257N     P=0.507N     P=0.547N    |P=0.664      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.553N     P=0.247N     P=0.511N     P=0.537N    |P=0.625      (e)          P=0.488      (e)          | 
|POLY 1.5           |     P=0.550N     P=0.243N     P=0.509N     P=0.523N    |P=0.640      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.555N     P=0.252N     P=0.517N     P=0.552N    |P=0.610      (e)          P=0.485      (e)          | 
|LOGISTIC REGRESSION|     P=0.551N     (e)          P=0.486N     P=0.547N    |(e)          (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.544N     P=0.247N     P=0.500N     P=0.500N    |P=0.669      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    1/49 (2%)    1/49 (2%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/40.72      0/38.97      1/39.41      1/36.65     |0/43.24      0/38.70      1/40.77      0/37.93      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         2.5%         2.7%        |0.0%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     2/24 (8%)    0/22 (0%)    0/23 (0%)    1/21 (5%)   |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          489          733 (T)     |---          ---          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570N     P=0.257N     P=0.507N     P=0.547N    |P=0.664      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.553N     P=0.247N     P=0.511N     P=0.537N    |P=0.625      (e)          P=0.488      (e)          | 
|POLY 1.5           |     P=0.550N     P=0.243N     P=0.509N     P=0.523N    |P=0.640      (e)          P=0.493      (e)          | 
|POLY 6             |     P=0.555N     P=0.252N     P=0.517N     P=0.552N    |P=0.610      (e)          P=0.485      (e)          | 
|LOGISTIC REGRESSION|     P=0.551N     (e)          P=0.486N     P=0.547N    |(e)          (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.544N     P=0.247N     P=0.500N     P=0.500N    |P=0.669      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 26      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/49 (94%)  47/49 (96%)  47/49 (96%)  47/49 (96%) |38/49 (78%)  41/49 (84%)  43/49 (88%)  35/49 (71%)  | 
|POLY-3 RATE (b)    |     46/46.83     47/47.69     47/47.21     47/47.41    |38/47.95     41/46.03     43/47.56     35/43.61     | 
|POLY-3 PERCENT (g) |     98.2%        98.6%        99.6%        99.1%       |79.3%        89.1%        90.4%        80.3%        | 
|TERMINAL (d)       |     24/24 (100%) 22/22 (100%) 23/23 (100%) 21/21 (100%)|22/28 (79%)  19/21 (91%)  24/28 (86%)  19/24 (79%)  | 
|FIRST INCIDENCE    |     460          390          489          399         |509          509          440          482          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.173      P=0.291      P=0.327      P=0.160     |P=0.508N     P=0.042 *    P=0.195      P=0.356      | 
|POLY 3             |     P=0.484      P=0.886      P=0.758      P=0.821     |P=0.507N     P=0.141      P=0.100      P=0.558      | 
|POLY 1.5           |     P=0.367      P=0.680      P=0.457      P=0.578     |P=0.396N     P=0.193      P=0.109      P=0.544N     | 
|POLY 6             |     P=0.960      P=1.000N     P=1.000      P=1.000     |P=0.499      P=0.107      P=0.107      P=0.461      | 
|LOGISTIC REGRESSION|     P=0.092      P=0.362      P=0.517      P=0.125     |P=0.359N     P=0.206      P=0.133      P=0.542N     | 
|COCH-ARM / FISHERS |     P=0.441      P=0.500      P=0.500      P=0.500     |P=0.195N     P=0.305      P=0.143      P=0.322N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/49 (69%)  32/49 (65%)  34/49 (69%)  32/49 (65%) |26/49 (53%)  34/49 (69%)  26/49 (53%)  27/49 (55%)  | 
|POLY-3 RATE (b)    |     34/45.80     32/44.44     34/45.89     32/45.45    |26/46.43     34/46.28     26/45.98     27/45.85     | 
|POLY-3 PERCENT (g) |     74.2%        72.0%        74.1%        70.4%       |56.0%        73.5%        56.6%        58.9%        | 
|TERMINAL (d)       |     16/24 (67%)  13/22 (59%)  13/23 (57%)  11/21 (52%) |12/28 (43%)  12/21 (57%)  12/28 (43%)  9/24 (38%)   | 
|FIRST INCIDENCE    |     469          502          433          245         |572          440          440          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.344      P=0.516      P=0.425      P=0.399     |P=0.513      P=0.022 *    P=0.481      P=0.238      | 
|POLY 3             |     P=0.407N     P=0.499N     P=0.590N     P=0.428N    |P=0.349N     P=0.055      P=0.563      P=0.472      | 
|POLY 1.5           |     P=0.412N     P=0.467N     P=0.573      P=0.416N    |P=0.357N     P=0.062      P=0.569      P=0.468      | 
|POLY 6             |     P=0.415N     P=0.528N     P=0.556N     P=0.453N    |P=0.339N     P=0.050      P=0.556      P=0.479      | 
|LOGISTIC REGRESSION|     P=0.483N     P=0.468N     P=0.539      P=0.409N    |P=0.257N     P=0.092      P=0.543N     P=0.575N     | 
|COCH-ARM / FISHERS |     P=0.434N     P=0.415N     P=0.587N     P=0.415N    |P=0.329N     P=0.073      P=0.580N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/15/00                           EXPERIMENT: 05110 TEST: 02                                            Page 27      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                    NAPHTHALENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/49 (98%)  49/49 (100%) 48/49 (98%)  49/49 (100%)|44/49 (90%)  48/49 (98%)  47/49 (96%)  44/49 (90%)  | 
|POLY-3 RATE (b)    |     48/48.25     49/49.00     48/48.00     49/49.00    |44/48.56     48/49.00     47/48.22     44/48.00     | 
|POLY-3 PERCENT (g) |     99.5%        100.0%       100.0%       100.0%      |90.6%        98.0%        97.5%        91.7%        | 
|TERMINAL (d)       |     24/24 (100%) 22/22 (100%) 23/23 (100%) 21/21 (100%)|24/28 (86%)  20/21 (95%)  27/28 (96%)  20/24 (83%)  | 
|FIRST INCIDENCE    |     460          390          433          245         |509          440          440          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.186      P=0.300      P=0.385      P=0.168     |P=0.371      P=0.028 *    P=0.283      P=0.175      | 
|POLY 3             |     P=0.943      P=0.999      P=0.999      P=0.999     |P=0.479N     P=0.124      P=0.151      P=0.571      | 
|POLY 1.5           |     P=0.595      P=0.842      P=0.848      P=0.842     |P=0.488N     P=0.113      P=0.166      P=0.553      | 
|POLY 6             |     P=1.000      P=1.000      P=1.000      P=1.000     |P=0.450N     P=0.142      P=0.153      P=0.603      | 
|LOGISTIC REGRESSION|     P=0.148      P=0.373      P=0.528      P=0.306     |P=0.411N     P=0.141      P=0.185      P=0.575      | 
|COCH-ARM / FISHERS |     P=0.438      P=0.500      P=0.753N     P=0.500     |P=0.354N     P=0.102      P=0.218      P=0.630N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.