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TDMS Study 05110-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                       NAPHTHALENE                                      DATE: 03/06/00       
EXPERIMENT: 05110 TEST: 02                                                                                     TIME: 11:09:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 52904C       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 91-20-3         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                      FINAL#2, CORE STUDY RATS                                                      
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                       NAPHTHALENE                                      DATE: 03/06/00     
EXPERIMENT: 05110 TEST: 02                                                                                     TIME: 11:09:10     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 52904C     
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 91-20-3       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                   NAPHTHALENE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hyperplasia
Adrenal Medulla                        Hyperplasia
Liver: Bile Duct                       Hyperplasia
Liver: Centrilobular                   Necrosis
Lung                                   Inflammation Chronic
Lung: Alveolar Epithelium              Hyperplasia
Nose: Glands                           Hyperplasia
                                       Metaplasia
Nose: Goblet Cell, Respiratory Epithelium
                                       Hyperplasia
Nose: Olfactory Epithelium             Atrophy
                                       Degeneration Hyaline
                                       Hyperplasia Atypical
                                       Inflammation Chronic
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Hyperplasia
                                       Metaplasia
Skin                                   Inflammation Chronic
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hyperplasia
Adrenal Medulla                        Hyperplasia
Kidney                                 Nephropathy
Liver                                  Clear Cell Focus
                                       Eosinophilic Focus
                                       Fatty Change
Lung                                   Inflammation Chronic
Lung: Alveolar Epithelium              Hyperplasia
Lung: Alveolus                         Infiltration Cellular Histiocyte
Nose: Glands                           Hyperplasia
                                       Metaplasia
Nose: Goblet Cell, Respiratory Epithelium
                                       Hyperplasia
Nose: Olfactory Epithelium             Atrophy
                                       Degeneration Hyaline
                                       Hyperplasia Atypical
                                       Inflammation Chronic
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Hyperplasia
                                       Metaplasia
Pancreas                               Atrophy
Pituitary Gland: Pars Distalis         Hyperplasia
Skin                                   Inflammation Acute
===============================================================
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/48 (0%)    0/49 (0%)   |2/49 (4%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |657          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.159N     P=0.298N     P=0.266N     P=0.300N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.124N     P=0.265N     P=0.252N     P=0.269N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.129N     P=0.253N     P=0.247N     P=0.258N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.281N     P=0.258N     P=0.283N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.139N     P=0.228N     P=0.227N     P=0.236N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.139N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    1/48 (2%)    1/49 (2%)   |4/49 (8%)    4/49 (8%)    3/49 (6%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         2.6%         2.7%        |9.2%         10.2%        7.3%         7.9%         |
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    1/23 (4%)    1/21 (5%)   |3/28 (11%)   3/21 (14%)   1/28 (4%)    2/24 (8%)    |
|FIRST INCIDENCE    |     ---          695          733 (T)      733 (T)     |713          581          586          680          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.508      P=0.211      P=0.492      P=0.473     |P=0.415N     P=0.499      P=0.506N     P=0.587N     |
|POLY 3             |     P=0.497      P=0.228      P=0.490      P=0.479     |P=0.429N     P=0.588      P=0.526N     P=0.569N     |
|POLY 1.5           |     P=0.514      P=0.232      P=0.493      P=0.487     |P=0.414N     P=0.611      P=0.517N     P=0.546N     |
|POLY 6             |     P=0.477      P=0.223      P=0.485      P=0.470     |P=0.442N     P=0.558      P=0.532N     P=0.593N     |
|LOGISTIC REGRESSION|     P=0.498      P=0.220      P=0.492      P=0.473     |P=0.438N     P=0.551      P=0.530N     P=0.612N     |
|COCH-ARM / FISHERS |     P=0.543      P=0.247      P=0.495      P=0.500     |P=0.381N     P=0.643N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/49 (61%)  28/49 (57%)  23/48 (48%)  36/49 (73%) |23/49 (47%)  12/49 (24%)  18/49 (37%)  24/49 (49%)  |
|POLY-3 ADJUSTED (b)|     66.5%        68.5%        56.5%        80.2%       |51.3%        29.5%        42.6%        57.7%        |
|TERMINAL (d)       |     17/24 (71%)  20/22 (91%)  16/23 (70%)  18/21 (86%) |17/28 (61%)  9/21 (43%)   13/28 (46%)  16/24 (67%)  |
|FIRST INCIDENCE    |     460          593          574          399         |602          440          586          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.042 *    P=0.536      P=0.213N     P=0.063     |P=0.098      P=0.116N     P=0.248N     P=0.230      |
|POLY 3             |     P=0.093      P=0.515      P=0.221N     P=0.094     |P=0.105      P=0.029N*    P=0.270N     P=0.347      |
|POLY 1.5           |     P=0.094      P=0.566N     P=0.177N     P=0.104     |P=0.121      P=0.022N*    P=0.245N     P=0.410      |
|POLY 6             |     P=0.097      P=0.381      P=0.295N     P=0.087     |P=0.091      P=0.044N*    P=0.292N     P=0.272      |
|LOGISTIC REGRESSION|     P=0.039 *    P=0.522N     P=0.153N     P=0.105     |P=0.088      P=0.038N*    P=0.296N     P=0.359      |
|COCH-ARM / FISHERS |     P=0.110      P=0.419N     P=0.133N     P=0.141     |P=0.154      P=0.017N*    P=0.206N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   6/49 (12%)   9/48 (19%)   4/49 (8%)   |7/49 (14%)   4/49 (8%)    12/49 (24%)  6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     16.9%        15.0%        22.9%        10.8%       |16.1%        10.2%        28.5%        15.3%        |
|TERMINAL (d)       |     4/24 (17%)   3/22 (14%)   7/23 (30%)   1/21 (5%)   |5/28 (18%)   2/21 (10%)   10/28 (36%)  4/24 (17%)   |
|FIRST INCIDENCE    |     657          593          615          685         |705          622          440          445          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.371N     P=0.551N     P=0.335      P=0.365N    |P=0.383      P=0.439N     P=0.147      P=0.615N     |
|POLY 3             |     P=0.361N     P=0.529N     P=0.344      P=0.328N    |P=0.364      P=0.321N     P=0.129      P=0.578N     |
|POLY 1.5           |     P=0.328N     P=0.517N     P=0.360      P=0.302N    |P=0.382      P=0.296N     P=0.138      P=0.552N     |
|POLY 6             |     P=0.401N     P=0.546N     P=0.318      P=0.360N    |P=0.347      P=0.355N     P=0.121      P=0.605N     |
|LOGISTIC REGRESSION|     P=0.358N     P=0.529N     P=0.329      P=0.343N    |P=0.361      P=0.387N     P=0.119      P=0.574N     |
|COCH-ARM / FISHERS |     P=0.278N     P=0.500N     P=0.375      P=0.262N    |P=0.430      P=0.262N     P=0.153      P=0.500N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/48 (4%)    1/49 (2%)   |4/49 (8%)    2/49 (4%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         5.1%         2.7%        |9.1%         5.1%         0.0%         2.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          695          613          632         |671          577          ---          624          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.316      P=0.465      P=0.223      P=0.462     |P=0.117N     P=0.436N     P=0.083N     P=0.258N     |
|POLY 3             |     P=0.327      P=0.492      P=0.229      P=0.481     |P=0.092N     P=0.388N     P=0.070N     P=0.223N     |
|POLY 1.5           |     P=0.342      P=0.495      P=0.231      P=0.488     |P=0.091N     P=0.366N     P=0.066N     P=0.207N     |
|POLY 6             |     P=0.311      P=0.488      P=0.227      P=0.474     |P=0.093N     P=0.417N     P=0.074N     P=0.241N     |
|LOGISTIC REGRESSION|     P=0.388      P=0.493      P=0.238      P=0.524     |P=0.075N     P=0.284N     P=0.060N     P=0.168N     |
|COCH-ARM / FISHERS |     P=0.370      P=0.500      P=0.242      P=0.500     |P=0.089N     P=0.339N     P=0.059N     P=0.181N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    3/48 (6%)    0/49 (0%)   |0/49 (0%)    2/49 (4%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         7.7%         0.0%        |0.0%         5.1%         0.0%         2.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    2/23 (9%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     639          615          643          ---         |---          679          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.478N     P=0.747      P=0.284      P=0.539N    |P=0.578      P=0.190      (e)          P=0.469      |
|POLY 3             |     P=0.472N     P=0.752      P=0.286      P=0.523N    |P=0.553      P=0.215      (e)          P=0.474      |
|POLY 1.5           |     P=0.453N     P=0.755      P=0.292      P=0.514N    |P=0.570      P=0.224      (e)          P=0.483      |
|POLY 6             |     P=0.494N     P=0.747      P=0.277      P=0.533N    |P=0.535      P=0.204      (e)          P=0.465      |
|LOGISTIC REGRESSION|     P=0.427N     P=0.746N     P=0.293      P=0.482N    |P=0.573      P=0.218      (e)          P=0.469      |
|COCH-ARM / FISHERS |     P=0.423N     P=0.753N     P=0.301      P=0.500N    |P=0.600      P=0.247      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     26/49 (53%)  13/49 (27%)  23/47 (49%)  12/49 (24%) |10/48 (21%)  3/49 (6%)    9/49 (18%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     59.2%        32.0%        57.0%        31.3%       |22.9%        7.6%         21.3%        12.8%        |
|TERMINAL (d)       |     15/24 (63%)  6/22 (27%)   12/23 (52%)  7/21 (33%)  |4/28 (14%)   0/21 (0%)    5/28 (18%)   2/24 (8%)    |
|FIRST INCIDENCE    |     460          593          600          469         |657          625          586          536          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.105N     P=0.028N*    P=0.472N     P=0.026N*   |P=0.386N     P=0.108N     P=0.562N     P=0.258N     |
|POLY 3             |     P=0.053N     P=0.008N**   P=0.508N     P=0.007N**  |P=0.324N     P=0.051N     P=0.534N     P=0.182N     |
|POLY 1.5           |     P=0.041N*    P=0.006N**   P=0.469N     P=0.005N**  |P=0.312N     P=0.042N*    P=0.514N     P=0.159N     |
|POLY 6             |     P=0.074N     P=0.010N*    P=0.552N     P=0.012N*   |P=0.336N     P=0.067N     P=0.554N     P=0.213N     |
|LOGISTIC REGRESSION|     P=0.060N     P=0.009N**   P=0.474N     P=0.008N**  |P=0.314N     P=0.041N*    P=0.497N     P=0.143N     |
|COCH-ARM / FISHERS |     P=0.031N*    P=0.006N**   P=0.421N     P=0.003N**  |P=0.283N     P=0.032N*    P=0.480N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    0/47 (0%)    0/49 (0%)   |2/48 (4%)    1/49 (2%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         0.0%        |4.7%         2.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          700          ---          ---         |677          663          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.520N     P=0.464      (e)          (e)         |P=0.121N     P=0.574N     P=0.256N     P=0.287N     |
|POLY 3             |     P=0.508N     P=0.492      (e)          (e)         |P=0.100N     P=0.532N     P=0.248N     P=0.265N     |
|POLY 1.5           |     P=0.505N     P=0.495      (e)          (e)         |P=0.101N     P=0.516N     P=0.242N     P=0.253N     |
|POLY 6             |     P=0.512N     P=0.488      (e)          (e)         |P=0.100N     P=0.554N     P=0.254N     P=0.279N     |
|LOGISTIC REGRESSION|     P=0.516N     P=0.491      (e)          (e)         |P=0.101N     P=0.488N     P=0.232N     P=0.244N     |
|COCH-ARM / FISHERS |     P=0.501N     P=0.500      (e)          (e)         |P=0.100N     P=0.492N     P=0.242N     P=0.242N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    1/48 (2%)    0/49 (0%)   |10/49 (20%)  4/49 (8%)    7/49 (14%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         0.0%        |22.4%        10.1%        16.9%        12.8%        |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |3/28 (11%)   1/21 (5%)    5/28 (18%)   2/24 (8%)    |
|FIRST INCIDENCE    |     ---          ---          707          ---         |657          574          587          482          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.652      (e)          P=0.478      (e)         |P=0.294N     P=0.189N     P=0.360N     P=0.261N     |
|POLY 3             |     P=0.625      (e)          P=0.490      (e)         |P=0.256N     P=0.109N     P=0.352N     P=0.195N     |
|POLY 1.5           |     P=0.641      (e)          P=0.493      (e)         |P=0.243N     P=0.092N     P=0.330N     P=0.170N     |
|POLY 6             |     P=0.608      (e)          P=0.486      (e)         |P=0.270N     P=0.136N     P=0.379N     P=0.229N     |
|LOGISTIC REGRESSION|     P=0.654      (e)          P=0.487      (e)         |P=0.244N     P=0.079N     P=0.323N     P=0.146N     |
|COCH-ARM / FISHERS |     P=0.668      (e)          P=0.495      (e)         |P=0.217N     P=0.074N     P=0.297N     P=0.131N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/49 (2%)    2/47 (4%)    2/49 (4%)    3/48 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         5.3%         4.9%         8.0%         |
|TERMINAL (d)       |                                                        |1/28 (4%)    1/21 (5%)    1/28 (4%)    3/24 (13%)   |
|FIRST INCIDENCE    |                                                        |734 (T)      663          715          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.217      P=0.409      P=0.500      P=0.250      |
|POLY 3             |                                                        |P=0.203      P=0.454      P=0.480      P=0.258      |
|POLY 1.5           |                                                        |P=0.215      P=0.467      P=0.487      P=0.271      |
|POLY 6             |                                                        |P=0.191      P=0.439      P=0.474      P=0.243      |
|LOGISTIC REGRESSION|                                                        |P=0.196      P=0.441      P=0.476      P=0.250      |
|COCH-ARM / FISHERS |                                                        |P=0.238      P=0.484      P=0.500      P=0.301      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/49 (4%)    0/47 (0%)    1/49 (2%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         0.0%         2.5%         2.6%         |
|TERMINAL (d)       |                                                        |2/28 (7%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE    |                                                        |734 (T)      ---          734 (T)      656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.570N     P=0.303N     P=0.500N     P=0.570N     |
|POLY 3             |                                                        |P=0.545N     P=0.269N     P=0.521N     P=0.545N     |
|POLY 1.5           |                                                        |P=0.546N     P=0.259N     P=0.513N     P=0.532N     |
|POLY 6             |                                                        |P=0.542N     P=0.281N     P=0.527N     P=0.557N     |
|LOGISTIC REGRESSION|                                                        |P=0.579N     (e)          P=0.500N     P=0.552N     |
|COCH-ARM / FISHERS |                                                        |P=0.545N     P=0.258N     P=0.500N     P=0.508N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/48 (8%)    2/48 (4%)    1/48 (2%)    3/48 (6%)   |5/48 (10%)   2/47 (4%)    6/46 (13%)   3/48 (6%)    |
|POLY-3 ADJUSTED (b)|     9.8%         5.3%         2.6%         8.4%        |11.7%        5.4%         15.5%        7.8%         |
|TERMINAL (d)       |     2/24 (8%)    2/22 (9%)    0/23 (0%)    2/20 (10%)  |4/28 (14%)   1/19 (5%)    4/26 (15%)   2/24 (8%)    |
|FIRST INCIDENCE    |     516          733 (T)      677          660         |671          609          587          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.548N     P=0.372N     P=0.203N     P=0.590N    |P=0.512N     P=0.371N     P=0.437      P=0.445N     |
|POLY 3             |     P=0.494N     P=0.368N     P=0.191N     P=0.568N    |P=0.509N     P=0.275N     P=0.431      P=0.414N     |
|POLY 1.5           |     P=0.486N     P=0.355N     P=0.185N     P=0.542N    |P=0.500N     P=0.253N     P=0.445      P=0.394N     |
|POLY 6             |     P=0.503N     P=0.387N     P=0.200N     P=0.597N    |P=0.519N     P=0.305N     P=0.419      P=0.438N     |
|LOGISTIC REGRESSION|     P=0.510N     P=0.345N     P=0.176N     P=0.533N    |P=0.503N     P=0.289N     P=0.421      P=0.374N     |
|COCH-ARM / FISHERS |     P=0.472N     P=0.339N     P=0.181N     P=0.500N    |P=0.476N     P=0.226N     P=0.470      P=0.357N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Cornea                                                                                                                      |
|     Infiltration Cellular Polymorphonuclear                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/48 (0%)    0/48 (0%)   |2/48 (4%)    0/47 (0%)    0/46 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.7%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/20 (0%)   |1/28 (4%)    0/19 (0%)    0/26 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |657          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.156N     P=0.314N     P=0.271N     P=0.294N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.125N     P=0.272N     P=0.264N     P=0.266N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.131N     P=0.259N     P=0.257N     P=0.256N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.291N     P=0.272N     P=0.278N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.146N     P=0.255N     P=0.250N     P=0.251N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.140N     P=0.253N     P=0.258N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    1/48 (2%)    1/48 (2%)    2/48 (4%)   |5/48 (10%)   2/47 (4%)    4/46 (9%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|     5.0%         2.6%         2.6%         5.6%        |11.7%        5.4%         10.4%        5.3%         |
|TERMINAL (d)       |     1/24 (4%)    1/22 (5%)    0/23 (0%)    1/20 (5%)   |4/28 (14%)   1/19 (5%)    3/26 (12%)   2/24 (8%)    |
|FIRST INCIDENCE    |     516          733 (T)      677          657         |671          609          587          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.481      P=0.520N     P=0.513N     P=0.639     |P=0.289N     P=0.371N     P=0.554N     P=0.292N     |
|POLY 3             |     P=0.506      P=0.521N     P=0.513N     P=0.652     |P=0.295N     P=0.275N     P=0.566N     P=0.268N     |
|POLY 1.5           |     P=0.517      P=0.512N     P=0.507N     P=0.668     |P=0.286N     P=0.253N     P=0.551N     P=0.250N     |
|POLY 6             |     P=0.495      P=0.533N     P=0.522N     P=0.634     |P=0.303N     P=0.305N     P=0.581N     P=0.291N     |
|LOGISTIC REGRESSION|     P=0.526      P=0.492N     P=0.494N     P=0.693N    |P=0.307N     P=0.289N     P=0.576N     P=0.298N     |
|COCH-ARM / FISHERS |     P=0.536      P=0.500N     P=0.500N     P=0.692N    |P=0.265N     P=0.226N     P=0.527N     P=0.218N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/49 (86%)  44/49 (90%)  37/48 (77%)  42/49 (86%) |32/49 (65%)  31/49 (63%)  31/49 (63%)  34/49 (69%)  |
|POLY-3 ADJUSTED (b)|     91.3%        92.3%        84.6%        91.7%       |70.4%        68.6%        70.2%        79.2%        |
|TERMINAL (d)       |     23/24 (96%)  21/22 (96%)  22/23 (96%)  21/21 (100%)|22/28 (79%)  15/21 (71%)  22/28 (79%)  21/24 (88%)  |
|FIRST INCIDENCE    |     460          390          433          399         |519          440          440          503          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.313      P=0.253      P=0.405N     P=0.216     |P=0.211      P=0.168      P=0.563N     P=0.116      |
|POLY 3             |     P=0.491N     P=0.590      P=0.223N     P=0.643     |P=0.159      P=0.517N     P=0.585N     P=0.225      |
|POLY 1.5           |     P=0.444N     P=0.501      P=0.199N     P=0.622     |P=0.202      P=0.513N     P=0.554N     P=0.273      |
|POLY 6             |     P=0.579      P=0.675      P=0.326N     P=0.634     |P=0.131      P=0.510N     P=0.598      P=0.198      |
|LOGISTIC REGRESSION|     P=0.522      P=0.306      P=0.217N     P=0.372     |P=0.165      P=0.548      P=0.506      P=0.118      |
|COCH-ARM / FISHERS |     P=0.379N     P=0.380      P=0.203N     P=0.613N    |P=0.335      P=0.500N     P=0.500N     P=0.415      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   2/49 (4%)    3/48 (6%)    2/49 (4%)   |2/49 (4%)    2/49 (4%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     12.1%        5.1%         7.6%         5.4%        |4.6%         5.1%         2.4%         2.6%         |
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    1/23 (4%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     639          643          630          600         |671          663          586          579          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.311N     P=0.261N     P=0.408N     P=0.301N    |P=0.378N     P=0.600      P=0.531N     P=0.574N     |
|POLY 3             |     P=0.267N     P=0.234N     P=0.383N     P=0.261N    |P=0.350N     P=0.656      P=0.519N     P=0.543N     |
|POLY 1.5           |     P=0.257N     P=0.227N     P=0.376N     P=0.243N    |P=0.343N     P=0.672      P=0.512N     P=0.528N     |
|POLY 6             |     P=0.279N     P=0.246N     P=0.397N     P=0.282N    |P=0.357N     P=0.636      P=0.524N     P=0.558N     |
|LOGISTIC REGRESSION|     P=0.249N     P=0.224N     P=0.372N     P=0.240N    |P=0.280N     P=0.699N     P=0.455N     P=0.467N     |
|COCH-ARM / FISHERS |     P=0.239N     P=0.218N     P=0.369N     P=0.218N    |P=0.325N     P=0.691N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/48 (4%)    1/49 (2%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         5.2%         2.7%        |0.0%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    1/23 (4%)    1/21 (5%)   |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      710          733 (T)     |---          ---          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.338      P=0.483      P=0.227      P=0.473     |P=0.664      (e)          P=0.500      (e)          |
|POLY 3             |     P=0.322      P=0.491      P=0.226      P=0.479     |P=0.625      (e)          P=0.488      (e)          |
|POLY 1.5           |     P=0.340      P=0.495      P=0.229      P=0.487     |P=0.640      (e)          P=0.493      (e)          |
|POLY 6             |     P=0.304      P=0.486      P=0.221      P=0.470     |P=0.610      (e)          P=0.485      (e)          |
|LOGISTIC REGRESSION|     P=0.326      P=0.483      P=0.216      P=0.473     |(e)          (e)          P=0.500      (e)          |
|COCH-ARM / FISHERS |     P=0.370      P=0.500      P=0.242      P=0.500     |P=0.669      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    0/49 (0%)    1/48 (2%)    3/49 (6%)   |0/48 (0%)    0/49 (0%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.1%         0.0%         2.6%         8.0%        |0.0%         0.0%         2.4%         2.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     502          ---          600          639         |---          ---          653          624          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.315      P=0.139N     P=0.338N     P=0.581     |P=0.194      (e)          P=0.470      P=0.465      |
|POLY 3             |     P=0.353      P=0.132N     P=0.331N     P=0.608     |P=0.200      (e)          P=0.494      P=0.480      |
|POLY 1.5           |     P=0.357      P=0.126N     P=0.322N     P=0.628     |P=0.207      (e)          P=0.498      P=0.488      |
|POLY 6             |     P=0.350      P=0.141N     P=0.344N     P=0.588     |P=0.195      (e)          P=0.492      P=0.473      |
|LOGISTIC REGRESSION|     P=0.441      P=0.091N     P=0.301N     P=0.599N    |P=0.248      (e)          P=0.537      P=0.555      |
|COCH-ARM / FISHERS |     P=0.368      P=0.121N     P=0.316N     P=0.661N    |P=0.221      (e)          P=0.505      P=0.505      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     43/49 (88%)  44/49 (90%)  45/48 (94%)  43/49 (88%) |41/48 (85%)  38/49 (78%)  34/49 (69%)  31/49 (63%)  |
|POLY-3 ADJUSTED (b)|     93.6%        96.8%        96.5%        92.8%       |88.9%        84.4%        78.2%        74.6%        |
|TERMINAL (d)       |     24/24 (100%) 22/22 (100%) 23/23 (100%) 20/21 (95%) |27/28 (96%)  20/21 (95%)  24/28 (86%)  19/24 (79%)  |
|FIRST INCIDENCE    |     460          520          433          399         |509          503          581          536          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.217      P=0.288      P=0.279      P=0.208     |P=0.098N     P=0.164      P=0.171N     P=0.305N     |
|POLY 3             |     P=0.410N     P=0.377      P=0.409      P=0.624N    |P=0.028N*    P=0.359N     P=0.111N     P=0.049N*    |
|POLY 1.5           |     P=0.513N     P=0.420      P=0.331      P=0.653N    |P=0.018N*    P=0.306N     P=0.080N     P=0.030N*    |
|POLY 6             |     P=0.252N     P=0.397      P=0.538      P=0.548N    |P=0.041N*    P=0.416N     P=0.152N     P=0.076N     |
|LOGISTIC REGRESSION|     P=0.254      P=0.328      P=0.218      P=0.358     |P=0.035N*    P=0.489N     P=0.122N     P=0.090N     |
|COCH-ARM / FISHERS |     P=0.559N     P=0.500      P=0.254      P=0.620N    |P=0.007N**   P=0.232N     P=0.050N     P=0.011N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/48 (4%)    0/49 (0%)   |2/49 (4%)    0/49 (0%)    4/49 (8%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         5.2%         0.0%        |4.6%         0.0%         9.6%         2.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    2/23 (9%)    0/21 (0%)   |2/28 (7%)    0/21 (0%)    2/28 (7%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          726          733 (T)      ---         |734 (T)      ---          586          617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.631N     P=0.483      P=0.228      (e)         |P=0.540      P=0.303N     P=0.328      P=0.553N     |
|POLY 3             |     P=0.640N     P=0.491      P=0.225      (e)         |P=0.525      P=0.262N     P=0.320      P=0.542N     |
|POLY 1.5           |     P=0.626N     P=0.495      P=0.229      (e)         |P=0.536      P=0.252N     P=0.325      P=0.528N     |
|POLY 6             |     P=0.619      P=0.486      P=0.220      (e)         |P=0.517      P=0.277N     P=0.317      P=0.555N     |
|LOGISTIC REGRESSION|     P=0.636N     P=0.478      P=0.228      (e)         |P=0.563      (e)          P=0.337      P=0.530N     |
|COCH-ARM / FISHERS |     P=0.601N     P=0.500      P=0.242      (e)         |P=0.567      P=0.247N     P=0.339      P=0.500N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    1/48 (2%)    0/49 (0%)   |2/49 (4%)    4/49 (8%)    2/49 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.6%         2.6%         0.0%        |4.6%         10.3%        4.9%         2.6%         |
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    1/23 (4%)    0/21 (0%)   |1/28 (4%)    3/21 (14%)   1/28 (4%)    1/24 (4%)    |
|FIRST INCIDENCE    |     634          733 (T)      733 (T)      ---         |509          721          624          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.338N     P=0.745      P=0.741      P=0.545N    |P=0.251N     P=0.236      P=0.676      P=0.551N     |
|POLY 3             |     P=0.329N     P=0.749      P=0.748      P=0.523N    |P=0.278N     P=0.281      P=0.671      P=0.551N     |
|POLY 1.5           |     P=0.321N     P=0.754      P=0.752      P=0.514N    |P=0.261N     P=0.304      P=0.679      P=0.533N     |
|POLY 6             |     P=0.339N     P=0.742      P=0.741      P=0.533N    |P=0.297N     P=0.253      P=0.664      P=0.569N     |
|LOGISTIC REGRESSION|     P=0.328N     P=0.760      P=0.757      P=0.478N    |P=0.252N     P=0.307      P=0.634N     P=0.467N     |
|COCH-ARM / FISHERS |     P=0.307N     P=0.753N     P=0.747      P=0.500N    |P=0.228N     P=0.339      P=0.691N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     34/49 (69%)  31/49 (63%)  28/48 (58%)  32/49 (65%) |46/49 (94%)  44/49 (90%)  46/49 (94%)  44/49 (90%)  |
|POLY-3 ADJUSTED (b)|     77.1%        74.7%        67.8%        78.0%       |95.7%        93.9%        95.4%        96.8%        |
|TERMINAL (d)       |     22/24 (92%)  22/22 (100%) 20/23 (87%)  20/21 (95%) |28/28 (100%) 21/21 (100%) 28/28 (100%) 24/24 (100%) |
|FIRST INCIDENCE    |     469          551          489          245         |509          440          440          482          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.367      P=0.567N     P=0.256N     P=0.378     |P=0.365      P=0.106      P=0.461      P=0.216      |
|POLY 3             |     P=0.536      P=0.500N     P=0.216N     P=0.570     |P=0.400      P=0.524N     P=0.680N     P=0.631      |
|POLY 1.5           |     P=0.486N     P=0.422N     P=0.192N     P=0.545N    |P=0.485      P=0.437N     P=0.665N     P=0.696N     |
|POLY 6             |     P=0.424      P=0.619N     P=0.277N     P=0.433     |P=0.353      P=0.680N     P=0.730N     P=0.570      |
|LOGISTIC REGRESSION|     P=0.349      P=0.480N     P=0.224N     P=0.475     |P=0.382      P=0.619N     P=0.576      P=0.376      |
|COCH-ARM / FISHERS |     P=0.405N     P=0.335N     P=0.178N     P=0.415N    |P=0.388N     P=0.357N     P=0.661N     P=0.357N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/49 (29%)  14/49 (29%)  14/48 (29%)  11/49 (22%) |7/49 (14%)   16/49 (33%)  8/49 (16%)   6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     34.4%        35.9%        35.7%        30.0%       |16.2%        40.9%        19.6%        15.8%        |
|TERMINAL (d)       |     14/24 (58%)  14/22 (64%)  13/23 (57%)  11/21 (52%) |7/28 (25%)   15/21 (71%)  8/28 (29%)   6/24 (25%)   |
|FIRST INCIDENCE    |     733 (T)      733 (T)      574          733 (T)     |734 (T)      609          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.348N     P=0.474      P=0.546      P=0.461N    |P=0.112N     P<0.001 **   P=0.500      P=0.625      |
|POLY 3             |     P=0.362N     P=0.537      P=0.545      P=0.433N    |P=0.181N     P=0.010 *    P=0.450      P=0.601N     |
|POLY 1.5           |     P=0.325N     P=0.560      P=0.555      P=0.388N    |P=0.155N     P=0.015 *    P=0.469      P=0.566N     |
|POLY 6             |     P=0.406N     P=0.503      P=0.526      P=0.487N    |P=0.210N     P=0.005 **   P=0.433      P=0.601      |
|LOGISTIC REGRESSION|     P=0.415N     P=0.474      P=0.454      P=0.461N    |P=0.158N     P=0.002 **   P=0.500      P=0.625      |
|COCH-ARM / FISHERS |     P=0.267N     P=0.588N     P=0.563      P=0.322N    |P=0.116N     P=0.028 *    P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    3/49 (6%)    2/48 (4%)    2/49 (4%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     7.4%         7.7%         5.2%         5.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/24 (13%)   3/22 (14%)   2/23 (9%)    1/21 (5%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      707         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.409N     P=0.626      P=0.520N     P=0.566N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.398N     P=0.643      P=0.523N     P=0.547N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.386N     P=0.651      P=0.516N     P=0.529N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.412N     P=0.632      P=0.535N     P=0.566N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.423N     P=0.626      P=0.520N     P=0.583N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.363N     P=0.661N     P=0.510N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    2/49 (4%)    1/48 (2%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    6/49 (12%)   2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     7.4%         5.1%         2.6%         5.5%        |2.3%         0.0%         14.5%        5.3%         |
|TERMINAL (d)       |     3/24 (13%)   1/22 (5%)    1/23 (4%)    2/21 (10%)  |1/28 (4%)    0/21 (0%)    5/28 (18%)   1/24 (4%)    |
|FIRST INCIDENCE    |     733 (T)      713          733 (T)      733 (T)     |734 (T)      ---          587          722          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.453N     P=0.543N     P=0.318N     P=0.562N    |P=0.168      P=0.557N     P=0.056      P=0.443      |
|POLY 3             |     P=0.431N     P=0.519N     P=0.323N     P=0.548N    |P=0.138      P=0.522N     P=0.048 *    P=0.455      |
|POLY 1.5           |     P=0.423N     P=0.511N     P=0.318N     P=0.530N    |P=0.151      P=0.513N     P=0.051      P=0.470      |
|POLY 6             |     P=0.441N     P=0.530N     P=0.331N     P=0.568N    |P=0.126      P=0.534N     P=0.045 *    P=0.439      |
|LOGISTIC REGRESSION|     P=0.464N     P=0.554N     P=0.318N     P=0.562N    |P=0.147      (e)          P=0.047 *    P=0.429      |
|COCH-ARM / FISHERS |     P=0.408N     P=0.500N     P=0.316N     P=0.500N    |P=0.186      P=0.500N     P=0.056      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fatty Change                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/49 (4%)    4/48 (8%)    5/49 (10%)  |10/49 (20%)  3/49 (6%)    2/49 (4%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     4.9%         5.0%         10.1%        12.8%       |21.9%        7.6%         4.8%         10.0%        |
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    2/23 (9%)    0/21 (0%)   |1/28 (4%)    1/21 (5%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     657          502          560          469         |519          647          624          445          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.084      P=0.665      P=0.303      P=0.175     |P=0.135N     P=0.103N     P=0.030N*    P=0.164N     |
|POLY 3             |     P=0.093      P=0.682      P=0.319      P=0.195     |P=0.084N     P=0.063N     P=0.021N*    P=0.116N     |
|POLY 1.5           |     P=0.097      P=0.687      P=0.324      P=0.202     |P=0.084N     P=0.049N*    P=0.018N*    P=0.099N     |
|POLY 6             |     P=0.092      P=0.673      P=0.310      P=0.190     |P=0.084N     P=0.086N     P=0.026N*    P=0.138N     |
|LOGISTIC REGRESSION|     P=0.151      P=0.682N     P=0.329      P=0.304     |P=0.049N*    P=0.021N*    P=0.008N**   P=0.025N*    |
|COCH-ARM / FISHERS |     P=0.105      P=0.691N     P=0.329      P=0.218     |P=0.085N     P=0.035N*    P=0.014N*    P=0.074N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    3/49 (6%)    2/48 (4%)    2/49 (4%)   |4/49 (8%)    1/49 (2%)    6/49 (12%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     2.4%         7.5%         5.1%         5.3%        |9.1%         2.5%         14.4%        12.8%        |
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    1/23 (4%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    4/28 (14%)   1/24 (4%)    |
|FIRST INCIDENCE    |     692          505          643          600         |602          503          581          503          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.469      P=0.270      P=0.462      P=0.430     |P=0.165      P=0.246N     P=0.341      P=0.399      |
|POLY 3             |     P=0.485      P=0.295      P=0.484      P=0.470     |P=0.163      P=0.214N     P=0.332      P=0.425      |
|POLY 1.5           |     P=0.501      P=0.299      P=0.488      P=0.480     |P=0.172      P=0.199N     P=0.346      P=0.450      |
|POLY 6             |     P=0.470      P=0.288      P=0.476      P=0.459     |P=0.156      P=0.237N     P=0.318      P=0.398      |
|LOGISTIC REGRESSION|     P=0.554      P=0.315      P=0.487      P=0.533     |P=0.215      P=0.094N     P=0.379      P=0.540      |
|COCH-ARM / FISHERS |     P=0.530      P=0.309      P=0.492      P=0.500     |P=0.197      P=0.181N     P=0.370      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/48 (0%)    0/49 (0%)   |2/49 (4%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |713          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.146N     P=0.296N     P=0.243N     P=0.277N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.124N     P=0.263N     P=0.251N     P=0.268N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.130N     P=0.252N     P=0.246N     P=0.257N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.278N     P=0.255N     P=0.280N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.151N     P=0.287N     P=0.254N     P=0.283N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.139N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    2/49 (4%)    2/48 (4%)    2/49 (4%)   |6/49 (12%)   6/49 (12%)   7/49 (14%)   6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     7.3%         5.1%         5.1%         5.4%        |13.5%        15.2%        16.3%        15.1%        |
|TERMINAL (d)       |     1/24 (4%)    2/22 (9%)    1/23 (4%)    1/21 (5%)   |2/28 (7%)    3/21 (14%)   1/28 (4%)    1/24 (4%)    |
|FIRST INCIDENCE    |     660          733 (T)      563          624         |572          647          512          555          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.502N     P=0.546N     P=0.533N     P=0.580N    |P=0.453      P=0.445      P=0.464      P=0.486      |
|POLY 3             |     P=0.472N     P=0.524N     P=0.521N     P=0.547N    |P=0.475      P=0.535      P=0.474      P=0.541      |
|POLY 1.5           |     P=0.461N     P=0.514N     P=0.515N     P=0.530N    |P=0.492      P=0.572      P=0.482      P=0.567      |
|POLY 6             |     P=0.483N     P=0.540N     P=0.532N     P=0.568N    |P=0.464      P=0.490      P=0.471      P=0.518      |
|LOGISTIC REGRESSION|     P=0.476N     P=0.535N     P=0.510N     P=0.541N    |P=0.531N     P=0.604      P=0.612      P=0.566N     |
|COCH-ARM / FISHERS |     P=0.442N     P=0.500N     P=0.510N     P=0.500N    |P=0.537      P=0.620N     P=0.500      P=0.620N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    2/49 (4%)    1/48 (2%)    1/49 (2%)   |1/49 (2%)    2/49 (4%)    2/49 (4%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     2.5%         5.1%         2.6%         2.7%        |2.3%         5.0%         4.8%         5.2%         |
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     733 (T)      615          707          657         |707          471          587          579          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.554N     P=0.475      P=0.743      P=0.723     |P=0.375      P=0.442      P=0.471      P=0.426      |
|POLY 3             |     P=0.528N     P=0.490      P=0.750      P=0.739     |P=0.388      P=0.470      P=0.485      P=0.461      |
|POLY 1.5           |     P=0.518N     P=0.494      P=0.753      P=0.747     |P=0.402      P=0.483      P=0.490      P=0.473      |
|POLY 6             |     P=0.539N     P=0.486      P=0.746      P=0.731     |P=0.376      P=0.453      P=0.483      P=0.449      |
|LOGISTIC REGRESSION|     P=0.513N     P=0.499      P=0.743      P=0.742     |P=0.569      P=0.676      P=0.566      P=0.553      |
|COCH-ARM / FISHERS |     P=0.501N     P=0.500      P=0.747      P=0.753N    |P=0.433      P=0.500      P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     35/49 (71%)  32/49 (65%)  28/48 (58%)  21/49 (43%) |5/49 (10%)   5/49 (10%)   5/49 (10%)   6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     76.6%        71.1%        64.3%        51.0%       |11.3%        12.7%        12.1%        15.0%        |
|TERMINAL (d)       |     19/24 (79%)  14/22 (64%)  14/23 (61%)  8/21 (38%)  |0/28 (0%)    1/21 (5%)    3/28 (11%)   1/24 (4%)    |
|FIRST INCIDENCE    |     460          505          523          469         |602          625          587          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.050N     P=0.537N     P=0.264N     P=0.082N    |P=0.352      P=0.475      P=0.589      P=0.371      |
|POLY 3             |     P=0.004N**   P=0.355N     P=0.136N     P=0.007N**  |P=0.371      P=0.558      P=0.590      P=0.429      |
|POLY 1.5           |     P=0.003N**   P=0.349N     P=0.129N     P=0.005N**  |P=0.385      P=0.589      P=0.605      P=0.451      |
|POLY 6             |     P=0.007N**   P=0.358N     P=0.151N     P=0.012N*   |P=0.359      P=0.519      P=0.575      P=0.407      |
|LOGISTIC REGRESSION|     P=0.003N**   P=0.374N     P=0.138N     P=0.008N**  |P=0.425      P=0.617      P=0.632N     P=0.577      |
|COCH-ARM / FISHERS |     P=0.002N**   P=0.332N     P=0.127N     P=0.004N**  |P=0.420      P=0.630N     P=0.630N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/49 (27%)  11/49 (22%)  7/48 (15%)   4/49 (8%)   |11/49 (22%)  11/49 (22%)  7/49 (14%)   9/49 (18%)   |
|POLY-3 ADJUSTED (b)|     29.1%        26.6%        17.4%        10.5%       |23.9%        26.3%        16.4%        21.9%        |
|TERMINAL (d)       |     2/24 (8%)    1/22 (5%)    1/23 (4%)    0/21 (0%)   |0/28 (0%)    1/21 (5%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     469          567          613          526         |572          471          586          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.029N*    P=0.489N     P=0.177N     P=0.052N    |P=0.418N     P=0.394      P=0.320N     P=0.578      |
|POLY 3             |     P=0.015N*    P=0.492N     P=0.153N     P=0.032N*   |P=0.349N     P=0.494      P=0.268N     P=0.516N     |
|POLY 1.5           |     P=0.011N*    P=0.457N     P=0.134N     P=0.024N*   |P=0.325N     P=0.539      P=0.248N     P=0.476N     |
|POLY 6             |     P=0.021N*    P=0.532N     P=0.182N     P=0.046N*   |P=0.375N     P=0.434      P=0.291N     P=0.560N     |
|LOGISTIC REGRESSION|     P=0.005N**   P=0.367N     P=0.099N     P=0.007N**  |P=0.170N     P=0.401N     P=0.129N     P=0.258N     |
|COCH-ARM / FISHERS |     P=0.008N**   P=0.407N     P=0.114N     P=0.015N*   |P=0.277N     P=0.595N     P=0.217N     P=0.401N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    13/49 (27%)  6/48 (13%)   15/49 (31%) |16/49 (33%)  15/49 (31%)  19/49 (39%)  22/49 (45%)  |
|POLY-3 ADJUSTED (b)|     4.9%         32.5%        15.4%        39.1%       |36.2%        36.5%        44.6%        54.4%        |
|TERMINAL (d)       |     1/24 (4%)    8/22 (36%)   4/23 (17%)   9/21 (43%)  |12/28 (43%)  7/21 (33%)   14/28 (50%)  13/24 (54%)  |
|FIRST INCIDENCE    |     624          643          685          552         |604          574          440          547          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004 **   P=0.002 **   P=0.117      P<0.001 **  |P=0.050      P=0.343      P=0.318      P=0.053      |
|POLY 3             |     P=0.003 **   P<0.001 **   P=0.114      P<0.001 **  |P=0.032 *    P=0.580      P=0.278      P=0.065      |
|POLY 1.5           |     P=0.004 **   P<0.001 **   P=0.120      P<0.001 **  |P=0.042 *    P=0.560N     P=0.301      P=0.087      |
|POLY 6             |     P=0.002 **   P<0.001 **   P=0.105      P<0.001 **  |P=0.026 *    P=0.541      P=0.253      P=0.051      |
|LOGISTIC REGRESSION|     P=0.003 **   P<0.001 **   P=0.109      P<0.001 **  |P=0.028 *    P=0.522      P=0.252      P=0.043 *    |
|COCH-ARM / FISHERS |     P=0.009 **   P=0.002 **   P=0.127      P<0.001 **  |P=0.073      P=0.500N     P=0.337      P=0.150      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     23/49 (47%)  12/49 (24%)  9/48 (19%)   16/49 (33%) |4/49 (8%)    11/49 (22%)  11/49 (22%)  9/49 (18%)   |
|POLY-3 ADJUSTED (b)|     54.5%        29.7%        22.6%        40.1%       |9.2%         27.5%        26.3%        23.6%        |
|TERMINAL (d)       |     18/24 (75%)  8/22 (36%)   6/23 (26%)   8/21 (38%)  |3/28 (11%)   5/21 (24%)   9/28 (32%)   8/24 (33%)   |
|FIRST INCIDENCE    |     516          525          489          419         |671          609          581          677          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.298N     P=0.031N*    P=0.003N**   P=0.248N    |P=0.183      P=0.015 *    P=0.042 *    P=0.060      |
|POLY 3             |     P=0.188N     P=0.015N*    P=0.002N**   P=0.129N    |P=0.132      P=0.026 *    P=0.034 *    P=0.069      |
|POLY 1.5           |     P=0.187N     P=0.015N*    P=0.002N**   P=0.123N    |P=0.163      P=0.033 *    P=0.037 *    P=0.083      |
|POLY 6             |     P=0.187N     P=0.015N*    P=0.002N**   P=0.132N    |P=0.104      P=0.020 *    P=0.031 *    P=0.055      |
|LOGISTIC REGRESSION|     P=0.269N     P=0.024N*    P=0.004N**   P=0.192N    |P=0.146      P=0.022 *    P=0.034 *    P=0.050      |
|COCH-ARM / FISHERS |     P=0.184N     P=0.017N*    P=0.003N**   P=0.108N    |P=0.232      P=0.045 *    P=0.045 *    P=0.116      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/49 (22%)  9/49 (18%)   6/48 (13%)   15/49 (31%) |19/49 (39%)  7/49 (14%)   11/49 (22%)  14/49 (29%)  |
|POLY-3 ADJUSTED (b)|     25.6%        22.4%        15.1%        38.0%       |41.4%        17.2%        25.6%        34.2%        |
|TERMINAL (d)       |     7/24 (29%)   4/22 (18%)   2/23 (9%)    9/21 (43%)  |12/28 (43%)  3/21 (14%)   7/28 (25%)   7/24 (29%)   |
|FIRST INCIDENCE    |     460          643          523          245         |519          440          440          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.107      P=0.473N     P=0.186N     P=0.152     |P=0.533N     P=0.041N*    P=0.091N     P=0.401N     |
|POLY 3             |     P=0.115      P=0.463N     P=0.180N     P=0.162     |P=0.492N     P=0.011N*    P=0.086N     P=0.318N     |
|POLY 1.5           |     P=0.132      P=0.440N     P=0.168N     P=0.194     |P=0.481N     P=0.008N**   P=0.075N     P=0.273N     |
|POLY 6             |     P=0.095      P=0.484N     P=0.198N     P=0.130     |P=0.498N     P=0.017N*    P=0.098N     P=0.370N     |
|LOGISTIC REGRESSION|     P=0.146      P=0.407N     P=0.150N     P=0.250     |P=0.414N     P=0.003N**   P=0.050N     P=0.198N     |
|COCH-ARM / FISHERS |     P=0.158      P=0.401N     P=0.154N     P=0.246     |P=0.443N     P=0.006N**   P=0.062N     P=0.196N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/21 (0%)    0/20 (0%)    1/30 (3%)    0/28 (0%)   |1/49 (2%)    2/49 (4%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.1%         0.0%        |2.3%         5.2%         2.4%         2.6%         |
|TERMINAL (d)       |     0/12 (0%)    0/11 (0%)    0/14 (0%)    0/10 (0%)   |1/28 (4%)    2/21 (10%)   0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     ---          ---          728          ---         |734 (T)      734 (T)      587          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.658      (e)          P=0.500      (e)         |P=0.519N     P=0.399      P=0.753      P=0.728      |
|POLY 3             |     P=0.664      (e)          P=0.566      (e)         |P=0.533N     P=0.461      P=0.750      P=0.731      |
|POLY 1.5           |     P=0.682      (e)          P=0.569      (e)         |P=0.522N     P=0.478      P=0.754      P=0.741      |
|POLY 6             |     P=0.642      (e)          P=0.561      (e)         |P=0.544N     P=0.440      P=0.748      P=0.720      |
|LOGISTIC REGRESSION|     P=0.680      (e)          P=0.545      (e)         |P=0.534N     P=0.399      P=0.739N     P=0.728      |
|COCH-ARM / FISHERS |     P=0.717      (e)          P=0.588      (e)         |P=0.500N     P=0.500      P=0.753N     P=0.753N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/21 (0%)    0/20 (0%)    0/30 (0%)    0/28 (0%)   |2/49 (4%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/11 (0%)    0/14 (0%)    0/10 (0%)   |2/28 (7%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.142N     P=0.303N     P=0.238N     P=0.272N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.125N     P=0.262N     P=0.250N     P=0.267N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.130N     P=0.252N     P=0.245N     P=0.257N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.277N     P=0.254N     P=0.279N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.142N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.139N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/13 (23%)   0/6 (0%)     0/9 (0%)     1/8 (13%)   |0/13 (0%)    0/8 (0%)     0/7 (0%)     0/5 (0%)     |
|POLY-3 ADJUSTED (b)|     27.2%        0.0%         0.0%         13.4%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/7 (14%)    0/4 (0%)     0/5 (0%)     1/6 (17%)   |0/7 (0%)     0/6 (0%)     0/3 (0%)     0/3 (0%)     |
|FIRST INCIDENCE    |     657          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.317N     P=0.173N     P=0.161N     P=0.371N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.375N     P=0.242N     P=0.168N     P=0.450N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.371N     P=0.254N     P=0.170N     P=0.465N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.379N     P=0.234N     P=0.173N     P=0.438N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.344N     P=0.255N     P=0.171N     P=0.443N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.366N     P=0.295N     P=0.186N     P=0.502N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/13 (77%)  4/6 (67%)    8/9 (89%)    6/8 (75%)   |13/13 (100%) 7/8 (88%)    6/7 (86%)    5/5 (100%)   |
|POLY-3 ADJUSTED (b)|     77.9%        69.0%        88.9%        75.0%       |100.0%       87.5%        91.1%        100.0%       |
|TERMINAL (d)       |     5/7 (71%)    3/4 (75%)    4/5 (80%)    4/6 (67%)   |7/7 (100%)   5/6 (83%)    3/3 (100%)   3/3 (100%)   |
|FIRST INCIDENCE    |     502          677          600          659         |509          587          587          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.386N     P=0.175N     P=0.604N     P=0.297N    |P=0.251N     P=0.146N     P=0.304N     (e)          |
|POLY 3             |     P=0.569      P=0.565N     P=0.463      P=0.644N    |P=0.726      P=0.402N     P=0.652N     (e)          |
|POLY 1.5           |     P=0.551      P=0.550N     P=0.452      P=0.651N    |P=0.699N     P=0.402N     P=0.495N     (e)          |
|POLY 6             |     P=0.599      P=0.591N     P=0.483      P=0.631N    |P=0.708      P=0.402N     P=0.946N     (e)          |
|LOGISTIC REGRESSION|     P=0.446      P=0.627N     P=0.411      P=0.625     |P=0.672N     (e)          P=0.379N     (e)          |
|COCH-ARM / FISHERS |     P=0.535      P=0.520N     P=0.450      P=0.656N    |P=0.646N     P=0.381N     P=0.350N     (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/49 (24%)  18/49 (37%)  16/48 (33%)  9/48 (19%)  |2/49 (4%)    5/49 (10%)   5/49 (10%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     28.0%        43.4%        38.1%        23.8%       |4.6%         12.7%        11.8%        12.5%        |
|TERMINAL (d)       |     4/24 (17%)   8/22 (36%)   8/23 (35%)   4/21 (19%)  |2/28 (7%)    2/21 (10%)   1/28 (4%)    1/24 (4%)    |
|FIRST INCIDENCE    |     460          525          489          469         |734 (T)      625          440          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.265N     P=0.111      P=0.213      P=0.467N    |P=0.221      P=0.133      P=0.220      P=0.171      |
|POLY 3             |     P=0.233N     P=0.101      P=0.220      P=0.432N    |P=0.217      P=0.178      P=0.206      P=0.184      |
|POLY 1.5           |     P=0.193N     P=0.113      P=0.226      P=0.387N    |P=0.231      P=0.194      P=0.209      P=0.197      |
|POLY 6             |     P=0.297N     P=0.089      P=0.209      P=0.494N    |P=0.204      P=0.161      P=0.205      P=0.172      |
|LOGISTIC REGRESSION|     P=0.176N     P=0.120      P=0.234      P=0.371N    |P=0.365      P=0.160      P=0.261      P=0.394      |
|COCH-ARM / FISHERS |     P=0.150N     P=0.137      P=0.231      P=0.331N    |P=0.253      P=0.218      P=0.218      P=0.218      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/49 (12%)   7/49 (14%)   6/48 (13%)   3/48 (6%)   |7/49 (14%)   4/49 (8%)    3/49 (6%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     13.9%        16.8%        14.8%        8.0%        |15.6%        10.1%        7.2%         7.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    1/23 (4%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     469          502          560          600         |572          663          586          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.228N     P=0.472      P=0.574      P=0.329N    |P=0.203N     P=0.408N     P=0.219N     P=0.271N     |
|POLY 3             |     P=0.217N     P=0.470      P=0.577      P=0.315N    |P=0.151N     P=0.339N     P=0.186N     P=0.213N     |
|POLY 1.5           |     P=0.193N     P=0.481      P=0.589      P=0.289N    |P=0.146N     P=0.305N     P=0.175N     P=0.192N     |
|POLY 6             |     P=0.247N     P=0.458      P=0.562      P=0.346N    |P=0.158N     P=0.385N     P=0.198N     P=0.240N     |
|LOGISTIC REGRESSION|     P=0.104N     P=0.588      P=0.616N     P=0.164N    |P=0.081N     P=0.217N     P=0.096N     P=0.075N     |
|COCH-ARM / FISHERS |     P=0.160N     P=0.500      P=0.606      P=0.254N    |P=0.134N     P=0.262N     P=0.159N     P=0.159N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Glands                                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    49/49 (100%) 48/48 (100%) 48/48 (100%)|0/49 (0%)    48/49 (98%)  48/49 (98%)  42/49 (86%)  |
|POLY-3 ADJUSTED (b)|     2.5%         100.0%       100.0%       100.0%      |0.0%         98.0%        99.4%        93.2%        |
|TERMINAL (d)       |     1/24 (4%)    22/22 (100%) 23/23 (100%) 21/21 (100%)|0/28 (0%)    21/21 (100%) 28/28 (100%) 24/24 (100%) |
|FIRST INCIDENCE    |     733 (T)      390          433          399         |---          440          440          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Glands                                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    3/49 (6%)    14/48 (29%)  26/48 (54%) |0/49 (0%)    2/49 (4%)    20/49 (41%)  20/49 (41%)  |
|POLY-3 ADJUSTED (b)|     0.0%         7.7%         35.1%        62.3%       |0.0%         5.2%         46.8%        51.2%        |
|TERMINAL (d)       |     0/24 (0%)    3/22 (14%)   8/23 (35%)   9/21 (43%)  |0/28 (0%)    1/21 (5%)    12/28 (43%)  16/24 (67%)  |
|FIRST INCIDENCE    |     ---          733 (T)      643          526         |---          713          587          579          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.104      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.186      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.110      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.213      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.114      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.223      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.105      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.201      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.104      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.188      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.121      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.247      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Goblet Cell, Respiratory Epithelium                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    25/49 (51%)  29/48 (60%)  26/48 (54%) |0/49 (0%)    16/49 (33%)  29/49 (59%)  20/49 (41%)  |
|POLY-3 ADJUSTED (b)|     0.0%         59.8%        70.0%        65.1%       |0.0%         40.8%        67.5%        51.9%        |
|TERMINAL (d)       |     0/24 (0%)    17/22 (77%)  22/23 (96%)  19/21 (91%) |0/28 (0%)    14/21 (67%)  23/28 (82%)  18/24 (75%)  |
|FIRST INCIDENCE    |     ---          520          433          469         |---          581          440          617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    49/49 (100%) 48/48 (100%) 47/48 (98%) |0/49 (0%)    49/49 (100%) 49/49 (100%) 47/49 (96%)  |
|POLY-3 ADJUSTED (b)|     7.2%         100.0%       100.0%       99.4%       |0.0%         100.0%       100.0%       98.7%        |
|TERMINAL (d)       |     1/24 (4%)    22/22 (100%) 23/23 (100%) 21/21 (100%)|0/28 (0%)    21/21 (100%) 28/28 (100%) 24/24 (100%) |
|FIRST INCIDENCE    |     460          390          433          399         |---          440          440          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    45/49 (92%)  40/48 (83%)  38/48 (79%) |13/49 (27%)  46/49 (94%)  49/49 (100%) 45/49 (92%)  |
|POLY-3 ADJUSTED (b)|     7.3%         95.0%        90.7%        87.8%       |29.0%        96.3%        100.0%       97.7%        |
|TERMINAL (d)       |     2/24 (8%)    21/22 (96%)  22/23 (96%)  19/21 (91%) |8/28 (29%)   21/21 (100%) 28/28 (100%) 24/24 (100%) |
|FIRST INCIDENCE    |     703          390          523          469         |509          440          440          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Hyperplasia Atypical                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    48/49 (98%)  45/48 (94%)  46/48 (96%) |0/49 (0%)    48/49 (98%)  48/49 (98%)  43/49 (88%)  |
|POLY-3 ADJUSTED (b)|     0.0%         98.6%        95.8%        99.1%       |0.0%         98.0%        99.4%        94.6%        |
|TERMINAL (d)       |     0/24 (0%)    22/22 (100%) 22/23 (96%)  21/21 (100%)|0/28 (0%)    21/21 (100%) 28/28 (100%) 24/24 (100%) |
|FIRST INCIDENCE    |     ---          390          489          419         |---          440          440          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    49/49 (100%) 48/48 (100%) 48/48 (100%)|0/49 (0%)    47/49 (96%)  47/49 (96%)  45/49 (92%)  |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       100.0%       100.0%      |0.0%         96.3%        99.0%        96.9%        |
|TERMINAL (d)       |     0/24 (0%)    22/22 (100%) 23/23 (100%) 21/21 (100%)|0/28 (0%)    21/21 (100%) 28/28 (100%) 24/24 (100%) |
|FIRST INCIDENCE    |     ---          390          433          399         |---          440          440          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    20/49 (41%)  19/48 (40%)  19/48 (40%) |8/49 (16%)   33/49 (67%)  34/49 (69%)  28/49 (57%)  |
|POLY-3 ADJUSTED (b)|     0.0%         48.2%        45.9%        48.4%       |18.1%        76.1%        74.0%        63.7%        |
|TERMINAL (d)       |     0/24 (0%)    11/22 (50%)  10/23 (44%)  11/21 (52%) |3/28 (11%)   16/21 (76%)  20/28 (71%)  14/24 (58%)  |
|FIRST INCIDENCE    |     ---          567          523          399         |657          581          440          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.004 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.003 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    21/49 (43%)  29/48 (60%)  29/48 (60%) |0/49 (0%)    18/49 (37%)  22/49 (45%)  23/49 (47%)  |
|POLY-3 ADJUSTED (b)|     7.4%         49.8%        64.5%        68.3%       |0.0%         43.9%        49.3%        53.5%        |
|TERMINAL (d)       |     2/24 (8%)    10/22 (46%)  12/23 (52%)  15/21 (71%) |0/28 (0%)    9/21 (43%)   10/28 (36%)  10/24 (42%)  |
|FIRST INCIDENCE    |     713          525          489          399         |---          503          480          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    15/49 (31%)  23/48 (48%)  18/48 (38%) |0/49 (0%)    21/49 (43%)  17/49 (35%)  15/49 (31%)  |
|POLY-3 ADJUSTED (b)|     0.0%         35.3%        51.9%        41.7%       |0.0%         46.9%        36.4%        34.5%        |
|TERMINAL (d)       |     0/24 (0%)    3/22 (14%)   7/23 (30%)   2/21 (10%)  |0/28 (0%)    2/21 (10%)   0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     ---          505          433          469         |---          471          440          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.021 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.017 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.015 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.025 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.074      P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.025 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |7/49 (14%)   9/49 (18%)   11/49 (22%)  8/49 (16%)   |
|POLY-3 ADJUSTED (b)|                                                        |15.9%        22.8%        26.6%        19.7%        |
|TERMINAL (d)       |                                                        |5/28 (18%)   6/21 (29%)   9/28 (32%)   3/24 (13%)   |
|FIRST INCIDENCE    |                                                        |572          574          587          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.406      P=0.211      P=0.204      P=0.379      |
|POLY 3             |                                                        |P=0.407      P=0.301      P=0.169      P=0.432      |
|POLY 1.5           |                                                        |P=0.430      P=0.339      P=0.187      P=0.458      |
|POLY 6             |                                                        |P=0.386      P=0.257      P=0.153      P=0.407      |
|LOGISTIC REGRESSION|                                                        |P=0.444      P=0.294      P=0.170      P=0.574N     |
|COCH-ARM / FISHERS |                                                        |P=0.468      P=0.393      P=0.217      P=0.500      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/49 (2%)    1/49 (2%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         2.6%         0.0%         5.3%         |
|TERMINAL (d)       |                                                        |1/28 (4%)    0/21 (0%)    0/28 (0%)    2/24 (8%)    |
|FIRST INCIDENCE    |                                                        |734 (T)      679          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.352      P=0.699      P=0.500N     P=0.446      |
|POLY 3             |                                                        |P=0.350      P=0.737      P=0.512N     P=0.454      |
|POLY 1.5           |                                                        |P=0.357      P=0.747      P=0.507N     P=0.470      |
|POLY 6             |                                                        |P=0.343      P=0.724      P=0.515N     P=0.438      |
|LOGISTIC REGRESSION|                                                        |P=0.333      P=0.736      (e)          P=0.446      |
|COCH-ARM / FISHERS |                                                        |P=0.370      P=0.753N     P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     19/49 (39%)  17/49 (35%)  17/48 (35%)  14/49 (29%) |18/49 (37%)  9/49 (18%)   11/49 (22%)  10/49 (20%)  |
|POLY-3 ADJUSTED (b)|     43.7%        40.6%        41.3%        34.5%       |40.1%        22.1%        25.6%        25.2%        |
|TERMINAL (d)       |     10/24 (42%)  8/22 (36%)   9/23 (39%)   4/21 (19%)  |14/28 (50%)  4/21 (19%)   6/28 (21%)   5/24 (21%)   |
|FIRST INCIDENCE    |     460          525          523          469         |509          471          586          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.344N     P=0.532N     P=0.503N     P=0.389N    |P=0.174N     P=0.145N     P=0.116N     P=0.151N     |
|POLY 3             |     P=0.231N     P=0.473N     P=0.498N     P=0.258N    |P=0.147N     P=0.056N     P=0.108N     P=0.108N     |
|POLY 1.5           |     P=0.216N     P=0.452N     P=0.473N     P=0.237N    |P=0.139N     P=0.045N*    P=0.104N     P=0.089N     |
|POLY 6             |     P=0.244N     P=0.498N     P=0.537N     P=0.274N    |P=0.149N     P=0.071N     P=0.106N     P=0.126N     |
|LOGISTIC REGRESSION|     P=0.218N     P=0.446N     P=0.468N     P=0.213N    |P=0.135N     P=0.042N*    P=0.096N     P=0.093N     |
|COCH-ARM / FISHERS |     P=0.182N     P=0.417N     P=0.448N     P=0.196N    |P=0.116N     P=0.035N*    P=0.092N     P=0.058N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    3/49 (6%)    2/48 (4%)    1/49 (2%)   |0/49 (0%)    1/49 (2%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.6%         5.2%         2.7%        |0.0%         2.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    2/22 (9%)    2/23 (9%)    1/21 (5%)   |0/28 (0%)    1/21 (5%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     ---          648          733 (T)      733 (T)     |---          734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.565      P=0.108      P=0.228      P=0.473     |P=0.506N     P=0.443      (e)          (e)          |
|POLY 3             |     P=0.547      P=0.111      P=0.225      P=0.479     |P=0.519N     P=0.478      (e)          (e)          |
|POLY 1.5           |     P=0.569      P=0.114      P=0.229      P=0.487     |P=0.511N     P=0.487      (e)          (e)          |
|POLY 6             |     P=0.521      P=0.108      P=0.220      P=0.470     |P=0.527N     P=0.466      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.554      P=0.110      P=0.228      P=0.473     |(e)          P=0.443      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.606      P=0.121      P=0.242      P=0.500     |P=0.500N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    0/47 (0%)    1/49 (2%)   |2/49 (4%)    2/49 (4%)    3/49 (6%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|     2.4%         0.0%         0.0%         2.7%        |4.6%         5.1%         7.3%         5.2%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    1/21 (5%)   |2/28 (7%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE    |     660          ---          ---          733 (T)     |734 (T)      663          587          643          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.529      P=0.511N     P=0.523N     P=0.721     |P=0.508      P=0.595      P=0.491      P=0.620      |
|POLY 3             |     P=0.548      P=0.510N     P=0.514N     P=0.736     |P=0.510      P=0.657      P=0.480      P=0.649      |
|POLY 1.5           |     P=0.552      P=0.506N     P=0.511N     P=0.745     |P=0.522      P=0.672      P=0.487      P=0.661      |
|POLY 6             |     P=0.544      P=0.516N     P=0.519N     P=0.724     |P=0.502      P=0.637      P=0.476      P=0.638      |
|LOGISTIC REGRESSION|     P=0.542      P=0.495N     P=0.507N     P=0.740     |P=0.531      P=0.633      P=0.486      P=0.658      |
|COCH-ARM / FISHERS |     P=0.560      P=0.500N     P=0.510N     P=0.753N    |P=0.550      P=0.691N     P=0.500      P=0.684      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/49 (22%)  12/49 (24%)  10/47 (21%)  15/49 (31%) |24/49 (49%)  13/49 (27%)  18/49 (37%)  15/48 (31%)  |
|POLY-3 ADJUSTED (b)|     26.3%        29.2%        25.2%        37.4%       |52.9%        32.0%        42.1%        36.8%        |
|TERMINAL (d)       |     7/24 (29%)   3/22 (14%)   6/23 (26%)   9/21 (43%)  |15/28 (54%)  6/21 (29%)   14/28 (50%)  7/24 (29%)   |
|FIRST INCIDENCE    |     469          593          600          399         |572          503          440          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.142      P=0.411      P=0.566N     P=0.149     |P=0.237N     P=0.158N     P=0.200N     P=0.201N     |
|POLY 3             |     P=0.178      P=0.482      P=0.553N     P=0.196     |P=0.176N     P=0.036N*    P=0.205N     P=0.094N     |
|POLY 1.5           |     P=0.193      P=0.486      P=0.549N     P=0.214     |P=0.175N     P=0.026N*    P=0.181N     P=0.081N     |
|POLY 6             |     P=0.160      P=0.490      P=0.559N     P=0.179     |P=0.175N     P=0.054N     P=0.240N     P=0.109N     |
|LOGISTIC REGRESSION|     P=0.183      P=0.465      P=0.561N     P=0.215     |P=0.215N     P=0.042N*    P=0.201N     P=0.090N     |
|COCH-ARM / FISHERS |     P=0.219      P=0.500      P=0.543N     P=0.246     |P=0.159N     P=0.018N*    P=0.154N     P=0.058N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    0/49 (0%)    2/47 (4%)    2/49 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         5.2%         5.3%        |                                                    |
|TERMINAL (d)       |     2/23 (9%)    0/22 (0%)    1/23 (4%)    0/21 (0%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      ---          523          552         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.373      P=0.247N     P=0.691N     P=0.661     |                                                    |
|POLY 3             |     P=0.378      P=0.241N     P=0.686      P=0.677     |                                                    |
|POLY 1.5           |     P=0.384      P=0.237N     P=0.687      P=0.685     |                                                    |
|POLY 6             |     P=0.375      P=0.245N     P=0.684      P=0.669     |                                                    |
|LOGISTIC REGRESSION|     P=0.436      (e)          P=0.687      P=0.667N    |                                                    |
|COCH-ARM / FISHERS |     P=0.397      P=0.242N     P=0.684      P=0.684N    |                                                    |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/49 (22%)  8/49 (16%)   16/48 (33%)  8/49 (16%)  |                                                    |
|POLY-3 ADJUSTED (b)|     26.6%        20.2%        40.6%        21.0%       |                                                    |
|TERMINAL (d)       |     7/24 (29%)   6/22 (27%)   13/23 (57%)  4/21 (19%)  |                                                    |
|FIRST INCIDENCE    |     615          600          630          562         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.517      P=0.395N     P=0.134      P=0.449N    |                                                    |
|POLY 3             |     P=0.531N     P=0.338N     P=0.130      P=0.373N    |                                                    |
|POLY 1.5           |     P=0.501N     P=0.324N     P=0.146      P=0.349N    |                                                    |
|POLY 6             |     P=0.534      P=0.359N     P=0.107      P=0.398N    |                                                    |
|LOGISTIC REGRESSION|     P=0.499      P=0.370N     P=0.097      P=0.412N    |                                                    |
|COCH-ARM / FISHERS |     P=0.443N     P=0.305N     P=0.166      P=0.305N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    2/49 (4%)    3/48 (6%)    2/49 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     7.3%         5.0%         7.6%         5.4%        |                                                    |
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    1/23 (4%)    0/21 (0%)   |                                                    |
|FIRST INCIDENCE    |     634          502          643          639         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.545N     P=0.541N     P=0.613      P=0.588N    |                                                    |
|POLY 3             |     P=0.515N     P=0.518N     P=0.641      P=0.549N    |                                                    |
|POLY 1.5           |     P=0.500N     P=0.510N     P=0.647      P=0.530N    |                                                    |
|POLY 6             |     P=0.531N     P=0.532N     P=0.631      P=0.569N    |                                                    |
|LOGISTIC REGRESSION|     P=0.467N     P=0.486N     P=0.653      P=0.521N    |                                                    |
|COCH-ARM / FISHERS |     P=0.473N     P=0.500N     P=0.651      P=0.500N    |                                                    |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    0/47 (0%)    0/49 (0%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         0.0%        |2.3%         0.0%         0.0%         5.2%         |
|TERMINAL (d)       |     0/24 (0%)    1/22 (5%)    0/23 (0%)    0/21 (0%)   |1/28 (4%)    0/21 (0%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |734 (T)      ---          ---          624          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.516N     P=0.483      (e)          (e)         |P=0.211      P=0.557N     P=0.500N     P=0.444      |
|POLY 3             |     P=0.508N     P=0.491      (e)          (e)         |P=0.220      P=0.522N     P=0.512N     P=0.458      |
|POLY 1.5           |     P=0.505N     P=0.495      (e)          (e)         |P=0.220      P=0.513N     P=0.507N     P=0.472      |
|POLY 6             |     P=0.512N     P=0.486      (e)          (e)         |P=0.221      P=0.534N     P=0.515N     P=0.444      |
|LOGISTIC REGRESSION|     (e)          P=0.483      (e)          (e)         |P=0.206      (e)          (e)          P=0.466      |
|COCH-ARM / FISHERS |     P=0.501N     P=0.500      (e)          (e)         |P=0.223      P=0.500N     P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/48 (8%)    2/48 (4%)    0/48 (0%)    1/48 (2%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     9.9%         5.2%         0.0%         2.8%        |0.0%         0.0%         0.0%         2.6%         |
|TERMINAL (d)       |     1/23 (4%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     660          695          ---          639         |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.378N     P=0.077N     P=0.246N    |P=0.186      (e)          (e)          P=0.469      |
|POLY 3             |     P=0.092N     P=0.361N     P=0.065N     P=0.212N    |P=0.180      (e)          (e)          P=0.474      |
|POLY 1.5           |     P=0.091N     P=0.351N     P=0.063N     P=0.199N    |P=0.183      (e)          (e)          P=0.483      |
|POLY 6             |     P=0.094N     P=0.375N     P=0.070N     P=0.228N    |P=0.177      (e)          (e)          P=0.465      |
|LOGISTIC REGRESSION|     P=0.095N     P=0.348N     P=0.063N     P=0.186N    |(e)          (e)          (e)          P=0.469      |
|COCH-ARM / FISHERS |     P=0.089N     P=0.339N     P=0.059N     P=0.181N    |P=0.191      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    1/48 (2%)    0/48 (0%)    0/48 (0%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.2%         |
|TERMINAL (d)       |     0/23 (0%)    1/22 (5%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |---          ---          ---          536          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.511N     P=0.491      (e)          (e)         |P=0.041 *    (e)          (e)          P=0.213      |
|POLY 3             |     P=0.506N     P=0.492      (e)          (e)         |P=0.040 *    (e)          (e)          P=0.212      |
|POLY 1.5           |     P=0.504N     P=0.495      (e)          (e)         |P=0.041 *    (e)          (e)          P=0.220      |
|POLY 6             |     P=0.511N     P=0.488      (e)          (e)         |P=0.040 *    (e)          (e)          P=0.204      |
|LOGISTIC REGRESSION|     (e)          P=0.491      (e)          (e)         |P=0.051      (e)          (e)          P=0.271      |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      (e)          (e)         |P=0.044 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/48 (8%)    1/48 (2%)    0/48 (0%)    0/48 (0%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     10.0%        2.6%         0.0%         0.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/23 (4%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     660          695          ---          ---         |572          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.033N*    P=0.221N     P=0.079N     P=0.093N    |P=0.348N     P=0.513N     P=0.509N     P=0.532N     |
|POLY 3             |     P=0.022N*    P=0.192N     P=0.064N     P=0.075N    |P=0.308N     P=0.524N     P=0.514N     P=0.528N     |
|POLY 1.5           |     P=0.022N*    P=0.186N     P=0.062N     P=0.069N    |P=0.317N     P=0.514N     P=0.509N     P=0.518N     |
|POLY 6             |     P=0.022N*    P=0.200N     P=0.068N     P=0.082N    |P=0.298N     P=0.538N     P=0.519N     P=0.539N     |
|LOGISTIC REGRESSION|     P=0.027N*    P=0.192N     P=0.066N     P=0.077N    |P=0.237N     P=0.341N     P=0.361N     P=0.397N     |
|COCH-ARM / FISHERS |     P=0.024N*    P=0.181N     P=0.059N     P=0.059N    |P=0.331N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   12/49 (24%)  6/48 (13%)   6/49 (12%)  |3/49 (6%)    3/49 (6%)    3/49 (6%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     16.7%        28.8%        15.4%        16.1%       |6.9%         7.6%         7.3%         5.2%         |
|TERMINAL (d)       |     3/24 (13%)   4/22 (18%)   4/23 (17%)   3/21 (14%)  |1/28 (4%)    0/21 (0%)    2/28 (7%)    0/24 (0%)    |
|FIRST INCIDENCE    |     502          502          681          657         |707          663          660          617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.299N     P=0.133      P=0.549N     P=0.611     |P=0.456N     P=0.543      P=0.640      P=0.580N     |
|POLY 3             |     P=0.276N     P=0.143      P=0.555N     P=0.590N    |P=0.435N     P=0.618      P=0.637      P=0.552N     |
|POLY 1.5           |     P=0.245N     P=0.146      P=0.536N     P=0.556N    |P=0.423N     P=0.636      P=0.646      P=0.535N     |
|POLY 6             |     P=0.316N     P=0.142      P=0.583N     P=0.615     |P=0.445N     P=0.597      P=0.630      P=0.567N     |
|LOGISTIC REGRESSION|     P=0.241N     P=0.154      P=0.542N     P=0.573N    |P=0.410N     P=0.636      P=0.630      P=0.508N     |
|COCH-ARM / FISHERS |     P=0.199N     P=0.153      P=0.516N     P=0.500N    |P=0.393N     P=0.661N     P=0.661N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    3/49 (6%)    1/48 (2%)    4/49 (8%)   |2/49 (4%)    4/49 (8%)    1/49 (2%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     9.6%         7.6%         2.6%         10.5%       |4.6%         10.2%        2.4%         10.1%        |
|TERMINAL (d)       |     2/24 (8%)    1/22 (5%)    1/23 (4%)    1/21 (5%)   |1/28 (4%)    1/21 (5%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     460          684          733 (T)      526         |677          602          440          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.515      P=0.551N     P=0.200N     P=0.568     |P=0.356      P=0.243      P=0.513N     P=0.279      |
|POLY 3             |     P=0.545      P=0.533N     P=0.201N     P=0.592     |P=0.359      P=0.292      P=0.516N     P=0.296      |
|POLY 1.5           |     P=0.556      P=0.520N     P=0.194N     P=0.610     |P=0.372      P=0.311      P=0.510N     P=0.312      |
|POLY 6             |     P=0.534      P=0.549N     P=0.213N     P=0.574     |P=0.346      P=0.270      P=0.522N     P=0.280      |
|LOGISTIC REGRESSION|     P=0.568N     P=0.497N     P=0.181N     P=0.594N    |P=0.583N     P=0.314      P=0.371N     P=0.561      |
|COCH-ARM / FISHERS |     P=0.576      P=0.500N     P=0.187N     P=0.643N    |P=0.393      P=0.339      P=0.500N     P=0.339      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    1/49 (2%)    2/48 (4%)    2/49 (4%)   |0/49 (0%)    2/49 (4%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.2%         2.5%         5.0%         5.3%        |0.0%         5.1%         0.0%         2.6%         |
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    1/21 (5%)    0/28 (0%)    1/24 (4%)    |
|FIRST INCIDENCE    |     634          502          560          527         |---          581          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.588N     P=0.321N     P=0.539N     P=0.569N    |P=0.583      P=0.199      (e)          P=0.469      |
|POLY 3             |     P=0.556N     P=0.320N     P=0.520N     P=0.545N    |P=0.553      P=0.216      (e)          P=0.474      |
|POLY 1.5           |     P=0.548N     P=0.314N     P=0.514N     P=0.528N    |P=0.570      P=0.225      (e)          P=0.483      |
|POLY 6             |     P=0.564N     P=0.331N     P=0.529N     P=0.564N    |P=0.535      P=0.205      (e)          P=0.465      |
|LOGISTIC REGRESSION|     P=0.431N     P=0.274N     P=0.498N     P=0.461N    |P=0.594      P=0.267      (e)          P=0.469      |
|COCH-ARM / FISHERS |     P=0.533N     P=0.309N     P=0.510N     P=0.500N    |P=0.600      P=0.247      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    2/49 (4%)    1/48 (2%)    2/49 (4%)   |2/49 (4%)    1/49 (2%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.1%         5.0%         2.6%         5.4%        |4.6%         2.6%         2.4%         2.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     469          643          600          657         |676          581          615          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.474N     P=0.517N     P=0.335N     P=0.570N    |P=0.471N     P=0.569N     P=0.535N     P=0.586N     |
|POLY 3             |     P=0.435N     P=0.527N     P=0.331N     P=0.557N    |P=0.437N     P=0.536N     P=0.519N     P=0.545N     |
|POLY 1.5           |     P=0.425N     P=0.516N     P=0.322N     P=0.536N    |P=0.433N     P=0.521N     P=0.512N     P=0.530N     |
|POLY 6             |     P=0.447N     P=0.541N     P=0.343N     P=0.580N    |P=0.440N     P=0.556N     P=0.525N     P=0.561N     |
|LOGISTIC REGRESSION|     P=0.339N     P=0.451N     P=0.301N     P=0.430N    |P=0.378N     P=0.447N     P=0.473N     P=0.513N     |
|COCH-ARM / FISHERS |     P=0.408N     P=0.500N     P=0.316N     P=0.500N    |P=0.422N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/49 (4%)    2/48 (4%)    1/49 (2%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     4.8%         5.0%         5.0%         2.7%        |0.0%         0.0%         0.0%         2.6%         |
|TERMINAL (d)       |     1/24 (4%)    1/22 (5%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     460          502          547          419         |---          ---          ---          667          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.396N     P=0.675      P=0.686      P=0.527N    |P=0.170      (e)          (e)          P=0.444      |
|POLY 3             |     P=0.402N     P=0.678      P=0.680      P=0.535N    |P=0.181      (e)          (e)          P=0.475      |
|POLY 1.5           |     P=0.390N     P=0.685      P=0.683      P=0.522N    |P=0.184      (e)          (e)          P=0.484      |
|POLY 6             |     P=0.415N     P=0.670      P=0.676      P=0.551N    |P=0.178      (e)          (e)          P=0.467      |
|LOGISTIC REGRESSION|     P=0.211N     P=0.656N     P=0.697      P=0.322N    |P=0.192      (e)          (e)          P=0.511      |
|COCH-ARM / FISHERS |     P=0.370N     P=0.691N     P=0.684      P=0.500N    |P=0.191      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    6/49 (12%)   3/48 (6%)    2/49 (4%)   |3/49 (6%)    2/49 (4%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         14.9%        7.5%         5.4%        |6.8%         5.1%         4.8%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    2/22 (9%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     460          525          560          639         |519          677          615          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.491N     P=0.058      P=0.287      P=0.455     |P=0.115N     P=0.593N     P=0.545N     P=0.158N     |
|POLY 3             |     P=0.491N     P=0.050      P=0.289      P=0.460     |P=0.106N     P=0.556N     P=0.529N     P=0.148N     |
|POLY 1.5           |     P=0.467N     P=0.052      P=0.293      P=0.475     |P=0.101N     P=0.533N     P=0.518N     P=0.137N     |
|POLY 6             |     P=0.516N     P=0.048 *    P=0.285      P=0.446     |P=0.113N     P=0.586N     P=0.537N     P=0.161N     |
|LOGISTIC REGRESSION|     P=0.373N     P=0.067      P=0.296      P=0.575     |P=0.073N     P=0.441N     P=0.397N     P=0.081N     |
|COCH-ARM / FISHERS |     P=0.424N     P=0.056      P=0.301      P=0.500     |P=0.089N     P=0.500N     P=0.500N     P=0.121N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    1/48 (2%)    0/49 (0%)   |2/49 (4%)    2/48 (4%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         2.6%         0.0%        |4.6%         5.2%         0.0%         5.3%         |
|TERMINAL (d)       |     0/24 (0%)    2/22 (9%)    1/23 (4%)    0/21 (0%)   |2/28 (7%)    2/21 (10%)   0/28 (0%)    2/24 (8%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |734 (T)      734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.425N     P=0.218      P=0.492      (e)         |P=0.552N     P=0.588      P=0.238N     P=0.640      |
|POLY 3             |     P=0.435N     P=0.227      P=0.490      (e)         |P=0.549N     P=0.649      P=0.250N     P=0.646      |
|POLY 1.5           |     P=0.422N     P=0.231      P=0.493      (e)         |P=0.544N     P=0.665      P=0.245N     P=0.663      |
|POLY 6             |     P=0.451N     P=0.221      P=0.485      (e)         |P=0.554N     P=0.628      P=0.254N     P=0.628      |
|LOGISTIC REGRESSION|     (e)          P=0.218      P=0.492      (e)         |P=0.552N     P=0.588      (e)          P=0.640      |
|COCH-ARM / FISHERS |     P=0.401N     P=0.247      P=0.495      (e)         |P=0.533N     P=0.684      P=0.247N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   2/49 (4%)    2/48 (4%)    3/49 (6%)   |3/49 (6%)    2/48 (4%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     16.2%        5.1%         5.1%         7.9%        |6.8%         5.2%         2.4%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/22 (0%)    0/23 (0%)    0/21 (0%)   |0/28 (0%)    0/21 (0%)    0/28 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     469          643          643          527         |657          663          707          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.245N     P=0.104N     P=0.108N     P=0.229N    |P=0.087N     P=0.604N     P=0.356N     P=0.179N     |
|POLY 3             |     P=0.198N     P=0.100N     P=0.102N     P=0.214N    |P=0.071N     P=0.559N     P=0.332N     P=0.147N     |
|POLY 1.5           |     P=0.192N     P=0.091N     P=0.094N     P=0.192N    |P=0.067N     P=0.538N     P=0.321N     P=0.137N     |
|POLY 6             |     P=0.205N     P=0.113N     P=0.114N     P=0.241N    |P=0.075N     P=0.585N     P=0.343N     P=0.161N     |
|LOGISTIC REGRESSION|     P=0.123N     P=0.059N     P=0.073N     P=0.087N    |P=0.057N     P=0.458N     P=0.279N     P=0.101N     |
|COCH-ARM / FISHERS |     P=0.184N     P=0.080N     P=0.084N     P=0.159N    |P=0.061N     P=0.510N     P=0.309N     P=0.121N     |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    4/49 (8%)    2/48 (4%)    4/49 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.9%         10.1%        5.2%         10.7%       |                                                    |
|TERMINAL (d)       |     1/24 (4%)    3/22 (14%)   2/23 (9%)    2/21 (10%)  |                                                    |
|FIRST INCIDENCE    |     624          551          733 (T)      572         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.314      P=0.305      P=0.671      P=0.272     |                                                    |
|POLY 3             |     P=0.327      P=0.318      P=0.673      P=0.295     |                                                    |
|POLY 1.5           |     P=0.343      P=0.327      P=0.680      P=0.310     |                                                    |
|POLY 6             |     P=0.310      P=0.307      P=0.662      P=0.279     |                                                    |
|LOGISTIC REGRESSION|     P=0.337      P=0.328      P=0.673      P=0.323     |                                                    |
|COCH-ARM / FISHERS |     P=0.371      P=0.339      P=0.684      P=0.339     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Artery                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    0/48 (0%)    2/49 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         0.0%         5.5%        |                                                    |
|TERMINAL (d)       |     0/24 (0%)    2/22 (9%)    0/23 (0%)    2/21 (10%)  |                                                    |
|FIRST INCIDENCE    |     ---          733 (T)      ---          733 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.261      P=0.218      (e)          P=0.208     |                                                    |
|POLY 3             |     P=0.262      P=0.227      (e)          P=0.214     |                                                    |
|POLY 1.5           |     P=0.273      P=0.231      (e)          P=0.223     |                                                    |
|POLY 6             |     P=0.250      P=0.221      (e)          P=0.204     |                                                    |
|LOGISTIC REGRESSION|     (e)          P=0.218      (e)          P=0.208     |                                                    |
|COCH-ARM / FISHERS |     P=0.290      P=0.247      (e)          P=0.247     |                                                    |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   9/49 (18%)   2/48 (4%)    11/49 (22%) |                                                    |
|POLY-3 ADJUSTED (b)|     11.5%        21.9%        5.0%         26.4%       |                                                    |
|TERMINAL (d)       |     0/24 (0%)    3/22 (14%)   0/23 (0%)    2/21 (10%)  |                                                    |
|FIRST INCIDENCE    |     460          525          433          419         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.106      P=0.182      P=0.248N     P=0.067     |                                                    |
|POLY 3             |     P=0.115      P=0.159      P=0.249N     P=0.067     |                                                    |
|POLY 1.5           |     P=0.122      P=0.172      P=0.238N     P=0.072     |                                                    |
|POLY 6             |     P=0.109      P=0.147      P=0.266N     P=0.064     |                                                    |
|LOGISTIC REGRESSION|     P=0.277      P=0.233      P=0.198N     P=0.214     |                                                    |
|COCH-ARM / FISHERS |     P=0.138      P=0.194      P=0.226N     P=0.085     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/46 (70%)  36/47 (77%)  31/45 (69%)  33/47 (70%) |39/47 (83%)  37/46 (80%)  37/48 (77%)  42/48 (88%)  |
|POLY-3 ADJUSTED (b)|     73.7%        81.9%        76.0%        75.7%       |85.2%        83.3%        81.4%        92.5%        |
|TERMINAL (d)       |     16/24 (67%)  17/22 (77%)  20/22 (91%)  14/20 (70%) |24/28 (86%)  16/21 (76%)  22/28 (79%)  22/24 (92%)  |
|FIRST INCIDENCE    |     460          435          523          419         |509          440          440          445          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.276      P=0.195      P=0.449      P=0.212     |P=0.148      P=0.175      P=0.527N     P=0.079      |
|POLY 3             |     P=0.491N     P=0.244      P=0.502      P=0.513     |P=0.155      P=0.518N     P=0.417N     P=0.205      |
|POLY 1.5           |     P=0.461N     P=0.262      P=0.558      P=0.534     |P=0.177      P=0.505N     P=0.383N     P=0.230      |
|POLY 6             |     P=0.543N     P=0.230      P=0.403      P=0.481     |P=0.152      P=0.524N     P=0.435N     P=0.203      |
|LOGISTIC REGRESSION|     P=0.510N     P=0.277      P=0.584N     P=0.546     |P=0.189      P=0.490N     P=0.396N     P=0.181      |
|COCH-ARM / FISHERS |     P=0.428N     P=0.298      P=0.562N     P=0.563     |P=0.296      P=0.480N     P=0.323N     P=0.370      |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/46 (4%)    0/47 (0%)    3/45 (7%)    0/47 (0%)   |0/47 (0%)    0/46 (0%)    1/48 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     5.2%         0.0%         8.1%         0.0%        |0.0%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     2/24 (8%)    0/22 (0%)    2/22 (9%)    0/20 (0%)   |0/28 (0%)    0/21 (0%)    1/28 (4%)    0/24 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          677          ---         |---          ---          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.400N     P=0.257N     P=0.460      P=0.278N    |P=0.664      (e)          P=0.500      (e)          |
|POLY 3             |     P=0.377N     P=0.238N     P=0.481      P=0.254N    |P=0.624      (e)          P=0.491      (e)          |
|POLY 1.5           |     P=0.362N     P=0.235N     P=0.486      P=0.244N    |P=0.641      (e)          P=0.496      (e)          |
|POLY 6             |     P=0.395N     P=0.242N     P=0.473      P=0.267N    |P=0.605      (e)          P=0.486      (e)          |
|LOGISTIC REGRESSION|     P=0.397N     (e)          P=0.456      (e)         |(e)          (e)          P=0.500      (e)          |
|COCH-ARM / FISHERS |     P=0.344N     P=0.242N     P=0.489      P=0.242N    |P=0.673      (e)          P=0.505      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/1 (100%)   1/2 (50%)    4/4 (100%)   0/2 (0%)    |0/0 (0%)     0/0 (0%)     0/1 (0%)     0/1 (0%)     |
|POLY-3 ADJUSTED (b)|     100.0%       59.7%        100.0%       0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     2/2 (100%)   0/1 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     460          525          650          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.253N     P=0.755      (e)          P=0.504N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.119N     P=0.714N     (e)          P=0.246N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.090N     P=0.660N     (e)          P=0.041N*   |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.162N     P=0.833N     (e)          P=0.418N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.148N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.154N     P=0.667N     (e)          P=0.333N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  03/06/00                           EXPERIMENT: 05110 TEST: 02                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    NAPHTHALENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      10 PPM       30 PPM       60 PPM      |CONTROL      10 PPM       30 PPM       60 PPM       |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Malformation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     1/2 (50%)    0/4 (0%)     2/2 (100%)  |0/0 (0%)     0/0 (0%)     1/1 (100%)   1/1 (100%)   |
|POLY-3 ADJUSTED (b)|     0.0%         73.1%        0.0%         100.0%      |0.0%         0.0%         100.0%       100.0%       |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/2 (0%)     1/1 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          643          ---          560         |---          ---          440          111          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.209      P=0.484      (e)          P=0.466     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.089      P=0.822      (e)          P=1.000N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.084      P=0.709      (e)          P=1.000N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.100      P=0.992      (e)          P=1.000N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.148      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.154      P=0.667      (e)          P=0.333     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).