National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/933

TDMS Study 05110-02 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Northwest                                       NAPHTHALENE                                      DATE: 03/06/00       

EXPERIMENT: 05110 TEST: 02                                                                                     TIME: 11:08:58       

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 52904C       

PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 91-20-3         

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                      FINAL#2, CORE STUDY RATS                                                      

                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    

LAB: Battelle Northwest                                       NAPHTHALENE                                      DATE: 03/06/00      

EXPERIMENT: 05110 TEST: 02                                                                                     TIME: 11:08:58      

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       

CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 52904C      

PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 91-20-3        
                                    NAPHTHALENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 49     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 24        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      460   460   469   502   516   572   615   615   624   634                 |

 |      639   657   658   660   660   677   678   692   695   703                 |

 |      708   709   713   721   726                                               |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 10 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 49     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 22        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      390   435   502   505   520   525   551   567   593   600                 |

 |      615   643   643   643   648   665   677   678   680   681                 |

 |      681   684   684   695   700   713   726                                   |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 30 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 48     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 23        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      433   489   523   547   560   563   574   582   600   613                 |

 |      613   615   630   643   643   650   663   677   681   681                 |

 |      685   685   707   710   728                                               |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                    NAPHTHALENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 60 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 49     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 21        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      245   399   419   469   496   526   527   539   552   560                 |

 |      562   572   575   600   608   624   632   639   657   659                 |

 |      660   671   685   685   703   707   712   722                             |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                    NAPHTHALENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   733 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  93.9  89.8  87.8  69.4  49.0      |

 |           |                                                                    |

 |           |                                                                    |

 |10 PPM     |   100.0 100.0 100.0 100.0  98.0  95.9  87.8  79.6  67.3  44.9      |

 |           |                                                                    |

 |           |                                                                    |

 |30 PPM     |   100.0 100.0 100.0 100.0 100.0  97.9  93.7  81.3  64.6  47.9      |

 |           |                                                                    |

 |           |                                                                    |

 |60 PPM     |   100.0 100.0  98.0  98.0  93.9  91.8  83.7  71.4  57.1  42.9      |

 |           |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      10 PPM       30 PPM       60 PPM   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       49.0%        44.9%        47.9%        42.9%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.433      P=0.702      P=0.880      P=0.414  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       630.5        616.4        619.8        585.9    |

 |NATURAL DEATHS (C)      |       (17.1)       (17.0)       (14.6)       (20.7)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       680.7        668.8        674.0        648.9    |

 |(STANDARD ERROR)        |       (11.4)       (12.5)       (11.2)       (15.8)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                    NAPHTHALENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 734 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 49     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 28        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      509   519   572   602   604   625   657   657   671   671                 |

 |      671   676   677   679   684   690   705   707   713   725                 |

 |      727                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 10 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 49     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 21        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      440   471   503   509   518   574   577   581   581   587                 |

 |      602   609   622   625   635   647   663   665   677   677                 |

 |      677   679   679   699   713   721   723   726                             |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 30 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 49     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 28        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      440   440   480   512   581   586   587   587   588   615                 |

 |      624   630   653   653   660   671   685   699   707   715                 |

 |      721                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                    NAPHTHALENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 734 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 60 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 49     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 24        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      111   429   445   478   482   503   536   547   555   579                 |

 |      601   617   624   625   625   642   643   656   667   677                 |

 |      680   684   685   720   722                                               |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                    NAPHTHALENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 734 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   734 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0 100.0 100.0 100.0 100.0 100.0  95.9  89.8  83.7  57.1      |

 |           |                                                                    |

 |           |                                                                    |

 |10 PPM     |   100.0 100.0 100.0 100.0 100.0  95.9  89.8  77.6  63.3  42.9      |

 |           |                                                                    |

 |           |                                                                    |

 |30 PPM     |   100.0 100.0 100.0 100.0 100.0  93.9  91.8  81.6  69.4  57.1      |

 |           |                                                                    |

 |           |                                                                    |

 |60 PPM     |   100.0  98.0  98.0  98.0  98.0  89.8  85.7  77.6  63.3  49.0      |

 |           |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      10 PPM       30 PPM       60 PPM   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       57.1%        42.9%        57.1%        49.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.572      P=0.127      P=0.892      P=0.277  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       654.3        620.7        611.1        581.3    |

 |NATURAL DEATHS (C)      |       (13.5)       (14.9)       (18.5)       (25.8)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       699.9        669.3        681.3        656.1    |

 |(STANDARD ERROR)        |       ( 8.0)       (11.7)       (11.8)       (17.1)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                            NAPHTHALENE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        10 PPM           = 2

                                                        30 PPM           = 3

                                                        60 PPM           = 4



------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                                      4                      2     3    1

      |                                        4                      24    32       3

      |                                                                4  4  2   11  3 12  3   3

      |                                                                           4   4121 2   33

P  90 +                                                                               4  1  4   331

E     |                                                                                    2   2 31      1

R     |                                                                                     44 2 23 3

C     |                                                                                      4 442  3 22 1 11

E  80 +                                                                                         44     2 2  11

N     |                                                                                          44      2   1 1

T     |                                                                                           44     3 3

      |                                                                                            4   44  3 221 1

S  70 +                                                                                                 4  4 32  1 1

U     |                                                                                                    44 3  2 2

R     |                                                                                                     44   3 1 1

V     |                                                                                                      4 4   2211

I  60 +                                                                                                        4 4    111

V     |                                                                                                          44

A     |                                                                                                           4 3  3

L     |                                                                                                             2 2311

   50 +                                                                                                             4 24211 1

      |                                                                                                                42 2 3

      |                                                                                                                 4 2 2

      |                                                                                                                   4 4

   40 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 34 obs hidden.
                                                            NAPHTHALENE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        10 PPM           = 2

                                                        30 PPM           = 3

                                                        60 PPM           = 4



----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                 4                                                  2          1

      |                   4                                                 42     2    1  1

      |                                                                     434    23  223 1      1    1

      |                                                                                 22         3   11

P  90 +                                                                             4  4 2        233   1  1

E     |                                                                                4     4    22       1   1

R     |                                                                                      4 4

C     |                                                                                        44  22    3     1  1

E  80 +                                                                                            42  2 3 3

N     |                                                                                                22 4       11

T     |                                                                                                 2 23   3

      |                                                                                                   222  3 3 11

S  70 +                                                                                                    4242  33 11

U     |                                                                                                       2  23 31 1

R     |                                                                                                      4 4    3 3

V     |                                                                                                        4 242  311

I  60 +                                                                                                           444  3131

V     |                                                                                                                  31 1

A     |

L     |                                                                                                            24 2  4

   50 +                                                                                                               2 224 4

      |                                                                                                                  22

      |

      |                                                                                                                   2 2

   40 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 24 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.