National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/941

TDMS Study 05110-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            NAPHTHALENE


NTP Experiment-Test: 05110-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05




       Facility:  Northrop Services, Inc.

       Chemical CAS #:  91-20-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          75           75           75           75                                     
  Scheduled Sacrifice                                  5            7            6            6                                     
  Early Deaths                                                                                                                      
    Dead                                               8            6           10            7                                     
    Moribund                                           2            1            6           10                                     
    Accident                                           1            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                59           56           51           50                                     
    Dead                                                                         1                                                  
    Accident                                                        1                                                               
  Missing                                                           3            1            2                                     
  Animals Examined Microscopically                    69           65           68           67                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (65)         (2)          (60)         (64)                                   
   Intestine Large, Cecum                             (66)         (1)          (60)         (64)                                   
   Intestine Large, Colon                             (67)         (2)          (62)         (66)                                   
   Intestine Large, Rectum                            (67)         (3)          (63)         (63)                                   
   Intestine Small, Duodenum                          (66)         (4)          (61)         (63)                                   
      Adenocarcinoma                                                1 (25%)                                                         
   Intestine Small, Ileum                             (66)         (1)          (61)         (63)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Intestine Small, Jejunum                           (65)         (1)          (61)         (63)                                   
   Liver                                              (68)         (12)         (67)         (67)                                   
      Hepatocellular Carcinoma                                                   1 (1%)                                             
      Hepatocellular Adenoma                           2 (3%)       2 (17%)                   2 (3%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (1%)                                
      Plasma Cell Tumor Malignant                                                1 (1%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (1%)                                
      Sarcoma Stromal, Metastatic                                   1 (8%)                                                          
   Mesentery                                          (6)                       (3)          (3)                                    
      Fat, Sarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (33%)                               
   Pancreas                                           (69)         (5)          (65)         (67)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (1%)                                
   Salivary Glands                                    (68)         (5)          (64)         (67)                                   
      Fibrosarcoma                                                                            1 (1%)                                
   Stomach, Forestomach                               (67)         (5)          (67)         (67)                                   
      Squamous Cell Carcinoma                                                                 1 (1%)                                
      Squamous Cell Papilloma                          2 (3%)                                                                       
   Stomach, Glandular                                 (67)         (5)          (65)         (67)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (4)          (68)         (67)                                   
      Fibrous Histiocytoma                                                                    1 (1%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (1%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (66)         (4)          (67)         (67)                                   
      Capsule, Adenoma                                 1 (2%)                                                                       
      Capsule, Sarcoma, Metastatic, Uncertain                                                                                       
          Primary Site                                                                        1 (1%)                                
   Adrenal Gland, Cortex                              (66)         (4)          (67)         (67)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (1%)                                             
   Adrenal Gland, Medulla                             (64)         (4)          (66)         (66)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (69)         (4)          (66)         (67)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (1%)                                
   Pituitary Gland                                    (61)         (4)          (50)         (54)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
   Thyroid Gland                                      (69)         (4)          (67)         (66)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (2)                                                 
      Osteosarcoma, Metastatic, Bone                                             1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                                            (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Ovary                                              (69)         (14)         (66)         (65)                                   
      Cystadenocarcinoma, Papillary                    1 (1%)       1 (7%)                                                          
      Cystadenoma, Papillary                           2 (3%)                    4 (6%)                                             
      Granulosa Cell Tumor Benign                      1 (1%)                    1 (2%)                                             
      Granulosa-Theca Tumor Benign                                                            1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma Stromal, Metastatic                                   1 (7%)                                                          
      Teratoma Benign                                                                         1 (2%)                                
      Endothelium, Sarcoma Stromal, Metastatic         1 (1%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Oviduct                                            (2)          (1)          (4)          (4)                                    
   Uterus                                             (69)         (41)         (67)         (66)                                   
      Sarcoma Stromal                                  1 (1%)       2 (5%)                                                          
      Endometrium, Polyp Stromal                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (69)         (4)          (68)         (67)                                   
      Hemangioma                                                                              1 (1%)                                
      Hemangiosarcoma                                                                         1 (1%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (1%)                                             
   Lymph Node                                         (69)         (9)          (67)         (67)                                   
      Iliac, Sarcoma Stromal, Metastatic, Uterus       1 (1%)                                                                       
      Inguinal, Osteosarcoma, Metastatic, Bone                                                1 (1%)                                
      Renal, Sarcoma Stromal, Metastatic, Uterus       1 (1%)                                                                       
   Lymph Node, Bronchial                              (46)         (1)          (46)         (40)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (3%)                                
   Lymph Node, Mandibular                             (66)         (6)          (62)         (65)                                   
      Fibrosarcoma                                                                            1 (2%)                                
   Lymph Node, Mediastinal                            (60)         (6)          (52)         (57)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Lymph Node, Mesenteric                             (67)         (4)          (60)         (62)                                   
   Spleen                                             (67)         (13)         (67)         (67)                                   
      Hemangiosarcoma                                                                         3 (4%)                                
      Plasma Cell Tumor Malignant                                                1 (1%)                                             
      Capsule, Sarcoma, Metastatic, Uncertain                                                                                       
          Primary Site                                                                        1 (1%)                                
   Thymus                                             (64)         (3)          (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (69)         (5)          (66)         (66)                                   
      Adenocarcinoma                                   2 (3%)       1 (20%)      1 (2%)       2 (3%)                                
   Skin                                               (69)         (6)          (67)         (67)                                   
      Squamous Cell Papilloma                                                    1 (1%)                                             
      Subcutaneous Tissue, Fibroma                                                            1 (1%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)       1 (17%)                   2 (3%)                                
      Subcutaneous Tissue, Sarcoma                                  1 (17%)                   1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (69)         (4)          (68)         (67)                                   
      Femur, Osteosarcoma                                                        1 (1%)                                             
      Humerus, Osteosarcoma                                                                   1 (1%)                                
   Skeletal Muscle                                                              (3)          (3)                                    
      Back, Osteosarcoma, Metastatic, Bone                                                    1 (33%)                               
      Hindlimb, Fibrosarcoma                                                     1 (33%)                                            
      Hindlimb, Hemangiosarcoma                                                               1 (33%)                               
      Sternal, Osteosarcoma, Metastatic, Bone                                    1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (69)         (4)          (68)         (67)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (68)         (4)          (64)         (64)                                   
   Lung                                               (69)         (65)         (68)         (67)                                   
      Adenocarcinoma, Metastatic, Mammary Gland                                  1 (1%)       1 (1%)                                
      Alveolar/Bronchiolar Adenoma                     5 (7%)       1 (2%)       9 (13%)     12 (18%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       4 (6%)       3 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                                          1 (1%)                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (1%)       1 (1%)                                
      Sarcoma, Metastatic, Skin                                                               1 (1%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (1%)                                
      Mediastinum, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                                        1 (1%)                                
   Nose                                               (69)         (65)         (68)         (67)                                   
      Adenoma                                                       2 (3%)                                                          
   Trachea                                            (69)         (4)          (68)         (66)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      Pinna, Fibrosarcoma                                           1 (100%)                                                        
   Eye                                                (2)          (6)          (2)          (4)                                    
      Lids, Squamous Cell Papilloma                                                           1 (25%)                               
   Harderian Gland                                    (1)          (2)          (1)          (1)                                    
      Adenocarcinoma                                                2 (100%)                                                        
      Adenoma                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (69)         (7)          (67)         (67)                                   
      Plasma Cell Tumor Malignant                                                1 (1%)                                             
   Urinary Bladder                                    (67)         (1)          (62)         (63)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(69)        *(65)        *(68)        *(67)                                   
      Lymphoma Malignant Histiocytic                   1 (1%)       2 (3%)       1 (1%)       3 (4%)                                
      Lymphoma Malignant Lymphocytic                   6 (9%)       5 (8%)       2 (3%)       2 (3%)                                
      Lymphoma Malignant Mixed                         1 (1%)       1 (2%)       4 (6%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            23          22          28          35                                       
     Total Primary Neoplasms                           28          25          33          48                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15           7          19          22                                       
     Total Benign Neoplasms                            15           7          19          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              12          18          12          19                                       
     Total Malignant Neoplasms                         13          18          14          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           3           4                                       
     Total Metastatic Neoplasm                          3           3          10          19                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          75           75           75           75                                     
  Scheduled Sacrifice                                  5            5            6            7                                     
  Early Deaths                                                                                                                      
    Moribund                                          13            7            3            5                                     
    Dead                                              31           10            2            5                                     
    Accident                                                                     2                                                  
  Survivors                                                                                                                         
    Dead                                                            1            1                                                  
    Terminal Sacrifice                                26           50           59           58                                     
    Accident                                                        1                                                               
  Missing                                                           1            2                                                  
  Animals Examined Microscopically                    70           69           67           68                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (57)         (7)          (61)         (65)                                   
   Intestine Large, Cecum                             (56)         (5)          (65)         (65)                                   
   Intestine Small, Duodenum                          (49)         (5)          (64)         (66)                                   
      Adenocarcinoma                                                             1 (2%)       1 (2%)                                
   Liver                                              (70)         (33)         (67)         (68)                                   
      Hemangiosarcoma                                                                         1 (1%)                                
      Hepatocellular Carcinoma                         6 (9%)       4 (12%)      4 (6%)       3 (4%)                                
      Hepatocellular Adenoma                           3 (4%)       8 (24%)      3 (4%)      12 (18%)                               
      Hepatocellular Adenoma, Multiple                              2 (6%)                    1 (1%)                                
   Mesentery                                          (1)                                    (1)                                    
   Pancreas                                           (67)         (10)         (66)         (68)                                   
   Salivary Glands                                    (69)         (11)         (67)         (68)                                   
   Stomach, Forestomach                               (63)         (10)         (65)         (68)                                   
   Stomach, Glandular                                 (62)         (10)         (65)         (68)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (10)         (67)         (68)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (66)         (9)          (65)         (68)                                   
      Adenoma                                                                    2 (3%)                                             
   Adrenal Gland, Medulla                             (66)         (11)         (64)         (66)                                   
      Pheochromocytoma Benign                          2 (3%)       1 (9%)                    1 (2%)                                
                                                             Page   8                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (67)         (9)          (66)         (68)                                   
   Pituitary Gland                                    (52)         (5)          (58)         (55)                                   
      Pars Distalis, Adenoma                                                     1 (2%)                                             
   Thyroid Gland                                      (67)         (8)          (66)         (68)                                   
      Follicular Cell, Adenoma                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (69)         (11)         (67)         (68)                                   
   Penis                                              (2)          (2)                       (1)                                    
   Prostate                                           (65)         (11)         (67)         (66)                                   
   Testes                                             (69)         (12)         (67)         (68)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (10)         (67)         (68)                                   
   Lymph Node                                         (67)         (14)         (67)         (68)                                   
   Lymph Node, Bronchial                              (38)         (5)          (57)         (43)                                   
   Lymph Node, Mandibular                             (61)         (8)          (59)         (66)                                   
   Lymph Node, Mediastinal                            (37)         (4)          (43)         (47)                                   
   Lymph Node, Mesenteric                             (57)         (4)          (66)         (63)                                   
   Spleen                                             (69)         (18)         (67)         (68)                                   
   Thymus                                             (47)         (1)          (63)         (63)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (69)         (21)         (67)         (68)                                   
      Subcutaneous Tissue, Fibroma                     3 (4%)       3 (14%)                   1 (1%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (1%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma               11 (16%)      6 (29%)                   4 (6%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (1%)                                 1 (1%)                                
      Subcutaneous Tissue, Neurofibrosarcoma           2 (3%)                                 1 (1%)                                
      Subcutaneous Tissue, Sarcoma                     6 (9%)       2 (10%)                   2 (3%)                                
      Subcutaneous Tissue, Sarcoma, Multiple                                                  1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (4)                                                              
      Sarcoma, Metastatic, Skin                                     1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (10)         (67)         (68)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (69)         (67)         (68)                                   
      Alveolar/Bronchiolar Adenoma                     7 (10%)     13 (19%)     12 (18%)      7 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (3%)       3 (4%)       5 (7%)                                
      Alveolar/Bronchiolar Carcinoma                                3 (4%)       4 (6%)       3 (4%)                                
      Fibrosarcoma, Metastatic                                      1 (1%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (1%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (4%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (1%)       1 (1%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (1%)                                             
   Nose                                               (70)         (69)         (67)         (68)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (1)          (1)          (1)                                    
      Adenoma                                          1 (100%)     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (16)         (67)         (68)                                   
      Adenoma                                          1 (1%)                                                                       
      Carcinoma                                                                               1 (1%)                                
   Urinary Bladder                                    (60)         (16)         (66)         (68)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(69)        *(67)        *(68)                                   
      Leukemia Granulocytic                                                                   1 (1%)                                
      Lymphoma Malignant Histiocytic                   1 (1%)       1 (1%)                                                          
      Lymphoma Malignant Lymphocytic                   3 (4%)       2 (3%)       3 (4%)       1 (1%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05110-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 02:12:05  
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         B6C3F1 MICE MALE                          CONTROL      10 PPM       30 PPM       30 PPM                                    
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          36          27          39                                       
     Total Primary Neoplasms                           49          48          34          48                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          24          19          25                                       
     Total Benign Neoplasms                            19          30          22          28                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          16          12          19                                       
     Total Malignant Neoplasms                         30          18          12          20                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           3           1                                                   
     Total Metastatic Neoplasm                          4           5           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.