National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/945

TDMS Study 05110-01 Pathology Tables

NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23




       Facility:  Northrop Services, Inc.

       Chemical CAS #:  91-20-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|             
                                           | 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |             2     3                             2                        |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       2                       2        1  2                 1  1         |             
      Inflammation, Chronic, Multifocal    |                                           2                              |             
      Pigmentation, Focal                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +                                               +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Inflammation, Focal, Granulomatous   |    2                                                                     |             
      Fat, Necrosis                        |                         2                                               2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Atrophy, Multifocal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       | 1                 2                                      1               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2  2                 2                        |             
      Inflammation, Multifocal             |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|             
                                           | 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                   1                                      1               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  2  2  2  2              2  2  2  2  2  2  2  2     2           2  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Valve, Pigmentation, Focal           |                                                                          |             
      Valve, Pigmentation, Multifocal      |                                        2     2                    2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Multifocal     | 3  4  3  3  3  3  3     3  3  3  2  3  3  2  3  3  2  2  3  3  3  3  3  3|             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  X                                       |             
      Congestion, Multifocal               |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Focal                  |                                                                          |             
      Focal Cellular Change                |       2                                   X                              |             
      Pigmentation, Focal                  |       2                                                  2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                               2                                          |             
      Follicle, Dilatation, Focal          |                               2                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|             
                                           | 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |                                                                          |             
      Follicular Cell, Hypertrophy,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X  X        X                    X  X                    3     X      |             
      Cyst, Multifocal                     | X                                                                        |             
      Pigmentation                         |                                                                          |             
      Follicle, Hemorrhage, Focal          |                                              2  3        2               |             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Mucosa, Vacuolization Cytoplasmic,   |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  2  3  3  3  2     3  3  3  3  3  2  3  3     2  3  3  3  3  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrous Osteodystrophy, Multifocal   |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Hyperplasia                          |                   3                                                      |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  M  +  M  +  +  M  +  M|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |             2                          2     2           2        2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                  2     2        2                 2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Erythrophagocytosis                  |                                                                          |             
      Giant Cell, Multifocal               | 2                                                                 2      |             
      Hemorrhage                           |                         3                       2     2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|             
                                           | 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal, Plasma Cell |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3                                                     2|             
      Hyperplasia, Lymphoid                | 3  2                          2                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Angiectasis                          |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Multifocal, Lymphocyte |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                                                                          |             
      Fibrous Osteodystrophy, Multifocal   |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                                                 2                        |             
      Mineralization, Focal                |                                                                   2      |             
      Mineralization, Multifocal           | 2  2     1  2  2  2                 2  2  2     2  2     2     2     2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                            1                                             |             
      Infiltration Cellular, Lymphocyte    | 2        2  2                 2                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                3     2                                                   |             
      Glands, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|             
                                           | 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Multifocal,    |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Pigmentation                         |                                                                          |             
      Bilateral, Lens, Cataract            |                                                                          |             
      Cornea, Degeneration                 |                                                                          |             
      Optic Nerve, Degeneration            |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |                                                                          |             
      Infarct, Focal                       |             2                                                            |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                   2        1                                             |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  2     2                    2  2  2  2  3  2  2     2  2  2  2  2  2  2|             
      Metaplasia, Focal, Osseous           |                            2                                             |             
      Nephropathy                          |                                                                          |             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                     2                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2     2  2  2        2        2  2     2  2  2  2     2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                      X                                                   |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                              1                           |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2                       1              3  2        3  2     3         |             
      Inflammation, Chronic, Multifocal    |                                                                      2   |             
      Pigmentation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                               +                    +   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                      2   |             
      Inflammation, Chronic, Multifocal    | 3                                                                        |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                              4                           |             
      Atrophy, Multifocal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2     2  2  2  2              2  2            |             
      Inflammation, Multifocal             | 3                                            2                           |             
      Duct, Dilatation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |          2                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  2                       1     2  2  2  2  2        3  2  2  3  2     1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                       2                  |             
      Valve, Pigmentation, Focal           |                            2                                             |             
      Valve, Pigmentation, Multifocal      |    2              2                             2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Multifocal     | 3  3     2  2  3  3  3     3  3  3  3  2  3  3  3  2  3  2  3  3  3  3  3|             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Congestion, Multifocal               |             2                                                            |             
      Cyst                                 |                                  X                                       |             
      Degeneration, Focal                  |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
      Follicle, Dilatation, Focal          |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |                         2                                                |             
      Follicular Cell, Hypertrophy,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                          X            |             
      Cyst, Multifocal                     |                                                                          |             
      Pigmentation                         |                      2                                                   |             
      Follicle, Hemorrhage, Focal          |                                                                          |             
      Interstitium, Hyperplasia            |          2                                                               |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +  +                                                         |             
      Mucosa, Vacuolization Cytoplasmic,   |                                                                          |             
           Multifocal                      |                3                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  2     3     3  2  2  3  3  2  2  3  3  3        3  2  2  3  3  3  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           3                              |             
      Fibrous Osteodystrophy, Multifocal   |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                                   3         |             
      Hyperplasia                          |                                              3                           |             
      Myelofibrosis                        | 3                                         2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  M  +  M  +  +  M  M  +  M  M  +  +  M  M  +  +  +  M  +  M  M|             
      Pigmentation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                              3        3                  |             
      Pigmentation                         |          2        2  3           2  2  2                 2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Pigmentation                         |                      3              2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Giant Cell, Multifocal               |          2     2                                      2        2  2     2|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal, Plasma Cell |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                              3                           |             
      Hyperplasia, Lymphoid                |                                           3                    3        3|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M     +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Cyst, Multiple                       |                                                                   X      |             
      Hyperplasia, Lymphoid                |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                      2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Multifocal, Lymphocyte |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                         2                                                |             
      Fibrous Osteodystrophy, Multifocal   |    2                                   2                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Mineralization, Focal                |                                              2           1               |             
      Mineralization, Multifocal           |    1     2           2  2  2  2  2     2  2           2        2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2                       2     2     2              3        2         |             
      Infiltration Cellular, Histiocyte    | 2                                                                        |             
      Inflammation                         |                                              2                           |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Glands, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                                            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                2         |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Multifocal,    |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Pigmentation                         |                                                                          |             
      Bilateral, Lens, Cataract            |             3                                                            |             
      Cornea, Degeneration                 |                                                                          |             
      Optic Nerve, Degeneration            |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |             2                                                            |             
      Infarct, Focal                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1        2        2  2  2        2  2  2  2  2        2     2  2     2  2|             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Nephropathy                          |                                                                          |             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |          2                    2                                   1      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  2              2  2  2  2        2  2  2  2  2     3  2  2  3        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  66        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  65        |
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Basophilic Focus                     |                                                                   X      |      1     |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                2                                                         |      5  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                         2                                                |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                            2        2                                2   |     16  1.9|
      Inflammation, Chronic, Multifocal    |                                                                          |      2  2.0|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Atrophy, Diffuse                     |                                                             4            |      2  4.0|
      Atrophy, Multifocal                  |                                                                      2   |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Lymphocyte                       |                                                                          |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                      2  2        2     2  2  2     2                    2|     18  2.0|
      Inflammation, Multifocal             |                                                                      2   |      3  2.3|
      Duct, Dilatation                     |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                               2  2  2  2  2        2     2     2     2   |     40  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Valve, Pigmentation, Focal           |                                     2           2                        |      3  2.0|
      Valve, Pigmentation, Multifocal      |                                                                          |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Capsule, Hyperplasia, Multifocal     |                3  2  3     3  3  3  2  2  3  3  2  3  3  3  3  3  3  2  2|     66  2.8|
      Capsule, Inflammation, Chronic,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Congestion, Multifocal               |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Focal                  |                                        3                                 |      1  3.0|
      Focal Cellular Change                |                                                                          |      2  2.0|
      Pigmentation, Focal                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|  64        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  68        |
      Cyst, Focal                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  61        |
      Pars Distalis, Angiectasis           |                2                                                         |      1  2.0|
      Pars Distalis, Hyperplasia           |                                  2  2                       2            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Follicle, Dilatation, Focal          |                                        2                                 |      2  2.0|
      Follicular Cell, Hyperplasia, Focal  |                      2                                      2     2      |      3  2.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Follicular Cell, Hypertrophy,        |                                                                          |            |
          Multifocal                       |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Cyst                                 |                                  X                                X      |     11  3.0|
      Cyst, Multifocal                     |                                                                          |      1     |
      Pigmentation                         |                                                                          |      1  2.0|
      Follicle, Hemorrhage, Focal          |                                                                          |      3  2.3|
      Interstitium, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
      Mucosa, Vacuolization Cytoplasmic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Angiectasis, Multifocal              |                                           3                              |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                3     3  4  2  3  3  2  2  3  3  2  2  4  3  3     3  3  4|     61  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fibrous Osteodystrophy, Multifocal   |                            2                                             |      1  2.0|
      Hyperplasia, Lymphoid                |                                              2                           |      4  2.3|
      Hyperplasia                          |                                                                          |      2  3.0|
      Myelofibrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                +  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Pigmentation                         |                                     2                 2                 2|     15  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         |                         2                             2                  |      8  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Erythrophagocytosis                  |                                     2                                2   |      2  2.0|
      Giant Cell, Multifocal               |                2     2        2     2  2     2     2  2  2               |     17  2.0|
      Hemorrhage                           |                      2                                                   |      4  2.3|
      Hyperplasia, Lymphoid                |                                              3                           |      1  3.0|
      Hyperplasia, Multifocal, Plasma Cell |                                           2                              |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hematopoietic Cell Proliferation     |                                                    3                     |      4  2.8|
      Hyperplasia, Lymphoid                |                                  2           3                       3   |      9  2.7|
      Hyperplasia, Plasma Cell             |                                           3                              |      1  3.0|
      Capsule, Inflammation, Chronic,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst, Multiple                       |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Hyperplasia, Focal                   |                                           3                 3            |      2  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Multifocal, Lymphocyte |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Fibrous Osteodystrophy, Focal        |                                                 2  X                     |      3  2.0|
      Fibrous Osteodystrophy, Multifocal   |                                     2                 2     2           3|      7  2.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Metaplasia, Focal, Osseous           |                                                                          |      1  2.0|
      Mineralization, Focal                |                                                                          |      3  1.7|
      Mineralization, Multifocal           |                                  2  2              2        2        2   |     34  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Congestion                           |                   3                                            2         |      2  2.5|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                  3                                       |     11  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation                         |                         1                          2                     |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                                  2                                       |      3  2.3|
      Glands, Inflammation                 |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation                         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Glands, Inflammation, Multifocal,    |                                                                          |            |
           Suppurative                     |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   2        |
      Pigmentation                         |                                                 4                        |      1  4.0|
      Bilateral, Lens, Cataract            |                                                                          |      1  3.0|
      Cornea, Degeneration                 |                                                 4                        |      1  4.0|
      Optic Nerve, Degeneration            |                                                 4                        |      1  4.0|
      Retina, Atrophy                      |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Congestion, Multifocal               |                                                                          |      1  2.0|
      Infarct, Focal                       |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      2  1.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2     2     2     2  2  3  2     2  2     2  2  2        2|     45  2.0|
      Metaplasia, Focal, Osseous           |                                                                          |      1  2.0|
      Nephropathy                          |                                                 2           1        2   |      3  1.7|
      Capsule, Inflammation, Chronic,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  67        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      4  1.8|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                      2  2     2  2  2  3  2  2  2  2  2  2  2            |     47  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|             
                                           | 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                   +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                   +      |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                            +              +                    +         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                +         |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                   +  +                       +                          +|             
      Cyst                                 |                   X  X                       X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|             
                                           | 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst, Multifocal                     |                                                                          |             
      Hematocyst, Focal                    |                                              X                          X|             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                           +                              |             
      Mucosa, Hyperplasia, Cystic          |                                           2                              |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +              +     +  +     +  +        +     +  +  +  +     +  +   |             
      Angiectasis, Multifocal              |                                                                          |             
      Dilatation                           |    2                                         3                           |             
      Endometrium, Hyperplasia, Cystic     |                   2     3  3     3  3        2     3  2  2  2     3  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            +                                             |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +                       +                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Infiltration Cellular, Histiocyte    |          3                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       2           2  2           2                    2  3  2            |             
      Infiltration Cellular, Histiocyte    |                            2                                             |             
      Inflammation, Granulomatous          | 2  2  2  2        2  2  3     2     2     2        2  2  2  2            |             
      Inflammation                         |                            2     2           2                          2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|             
                                           | 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1      |             
      Glands, Inflammation                 |                   2                                                  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  2  2        3  2  4  2  3  2  2     2  2  2  2  2  2  2  2  2  4  2|             
      Olfactory Epithelium, Metaplasia     | 2  3  3  2        3  2  4  2  1  2  2     2  3  3  3  3  3  3  2  3  3  2|             
      Respiratory Epithelium, Hyperplasia  | 2  2  3  3        3  2  4  3  2  2  2     2  2  3  3  2  2  2  2  3  4  2|             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Degeneration                         |                                                                          |             
      Lens, Cataract                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +                                +                              |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                           2                              |             
      Inflammation, Acute, Focal           |          2                                                               |             
      Nephropathy                          |                                                                          |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                     +                 A        +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                     +                 M        A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                     +                 M        +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +     +              +  A        A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +     +              +  A        A         |             
      Hyperplasia, Focal, Lymphoid         |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                     +                 M        A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                     +                 M        A         |             
                                            __________________________________________________________________________|             
   Liver                                   |                                     +        +        +        +         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                     +                 +        +     +   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                     +                 +        +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                     +                 +        +         |             
      Mineralization, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                     +                 +        +         |             
      Capsule, Hyperplasia, Multifocal     |                                     1                 2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                     M                 M        M         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                     +                 M        +         |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                     +                 +        +         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                     +                 M  +     +     +  +|             
      Cyst                                 |                                                          X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst, Multifocal                     |                                                                      X   |             
      Hematocyst, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Mucosa, Hyperplasia, Cystic          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +  +                 +     +     +           M  +  +  +     +  +|             
      Angiectasis, Multifocal              |    3                                                                     |             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    3     3  3                 4     2     4              3  2        4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                   +                 +        +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                     M                 +        M         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                     +                 +        +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +                                   +                 +        +         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                 M        +         |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                     +              +  +        +         |             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                     +                 M        +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                     +           +     +        +         |             
                                            __________________________________________________________________________|             
   Skin                                    |                                     +                 +        +         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                     +                 +        +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                     +                 +        +         |             
      Mineralization, Focal                |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                     +                 +        +         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +                 +     +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                               3           2              2           2   |             
      Infiltration Cellular, Histiocyte    |       2                                                        2         |             
      Inflammation, Granulomatous          | 3     2  2  3                 2           2  2  3  2        2        2  2|             
      Inflammation                         |    2                                                     2        2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           1                              |             
      Glands, Inflammation                 |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +                 +     +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  4  3  3                 3     2     2  3  3  3  2  3  2  2  2  3  2|             
      Olfactory Epithelium, Metaplasia     | 3  2  3  3  3                 3     2     2  2  4  3  2  3  1  1  2  3  2|             
      Respiratory Epithelium, Hyperplasia  | 3  2  4  3  3                 3     2     2  3  2  2  2  3  3  2  2  3  2|             
                                            __________________________________________________________________________|             
   Trachea                                 |                                     +                 +        +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                          +     +     +                              |             
      Degeneration                         |    4                          4           4                              |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                     +                 +        +         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Nephropathy                          |                                                                          |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                     M                 M        +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    A                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A                                                                     |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A                                                                     |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A                                                                     |   4        |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +        +  +     +                                               +   |  12        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                      3                                                   |      1  3.0|
      Necrosis, Multifocal                 |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                                                                     |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                                                                     |   5        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +                                                                     |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +                                                                     |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +                                                                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                                                                     |   4        |
      Mineralization, Multifocal           |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                                                                     |   4        |
      Capsule, Hyperplasia, Multifocal     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M                                                                     |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M                                                                     |   4        |
      Pars Distalis, Hyperplasia           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                                                                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  M        +        +                                +              +   |  14        |
      Cyst                                 | X           X                                         X              X   |      9     |
      Cyst, Multifocal                     |                                                                          |      1     |
      Hematocyst, Focal                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Mucosa, Hyperplasia, Cystic          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    M  +  +  +  +     +  +  +  +     +     +  +     +  +  +     +     +  +|  41        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |       4  2     4     3  2  3  3     2     3  2     3  3  3              3|     36  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                   +                          +      |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    M                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +                                                              +      |   6        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +                                   +                                 |   6        |
      Infiltration Cellular, Histiocyte    |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    M                                                              +      |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    A        +        +  +                 +              +  +     +      |  13        |
      Hematopoietic Cell Proliferation     |             2        2                                                   |      3  2.3|
      Hyperplasia, Lymphoid                |                                           2              2               |      3  2.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M                                   +                                 |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                                                                     |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +                                                                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                                                                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                                                                     |   4        |
      Mineralization, Focal                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Congestion                           |    3                                                                     |      1  3.0|
      Hemorrhage                           |                                           1                              |      1  1.0|
      Infiltration Cellular, Lymphocyte    | 2                             2  1     2  2  2        2  3     2  2      |     21  2.1|
      Infiltration Cellular, Histiocyte    |                      1           1                                       |      5  1.6|
      Inflammation, Granulomatous          | 2     2     2  2  2        2  2     2                 2     3  2     2   |     38  2.1|
      Inflammation                         |          3                             2     2     2     3        2      |     13  2.2|
      Alveolar Epithelium, Hyperplasia     |                2                                2     2        1         |      6  1.5|
      Glands, Inflammation                 |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Inflammation                         | 4  3  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     65  2.3|
      Olfactory Epithelium, Metaplasia     | 4  3  1  2  2  1  4  3  3  2  2  3  2  3  3  2  3  3  3  3  2  3  2  3  3|     65  2.5|
      Respiratory Epithelium, Hyperplasia  | 3  3  2  2  3  2  3  2  3  2  2  2  2  2  3  2  2  3  2  2  2  2  2  4  2|     65  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                                                                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   6        |
      Degeneration                         |                                                                          |      3  4.0|
      Lens, Cataract                       |                                                          2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +           +                                                         |   7        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Nephropathy                          |    4                                                                     |      1  4.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    M                                                                     |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|             
                                           | 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  A  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  A|             
      Hyperplasia, Focal, Lymphoid         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  A|             
      Hyperplasia, Focal, Lymphoid         |                      4                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Clear Cell Focus                     |                                                                         X|             
      Focal Cellular Change, Focal         |                                                       2                  |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                 1                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                            1        1                                    |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                         1                                                |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                2  2                             2  2                    2|             
      Mineralization, Focal                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                      3   |             
      Bile Duct, Cytoplasmic Alteration,   |                                                                          |             
           Multifocal                      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                         +                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Fat, Necrosis                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
      Atrophy, Multifocal                  |                               3                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                     1                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      1  2  1           2        1  2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|             
                                           | 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Multifocal             |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|       2                                                                  |             
      Duct, Dilatation                     |                               3                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2  2  2  2  2     2     2     2  2           2  2        2        2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Adventitia, Inflammation, Multifocal |                                                                          |             
      Media, Hypertrophy, Multifocal       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Valve, Pigmentation, Focal           |                                        2           2                     |             
      Valve, Pigmentation, Multifocal      |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Capsule, Hyperplasia, Multifocal     | 2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  3  3     3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Congestion, Multifocal               | 3                                                                       2|             
      Degeneration, Focal                  |       3                                                                  |             
      Hypertrophy, Focal                   |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Congestion, Multifocal               | 2                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  M|             
      Pars Distalis, Angiectasis           |                                                          2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Follicle, Dilatation, Focal          |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|             
                                           | 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |          2     X     X              X     X                              |             
      Cyst, Multifocal                     |                                                                          |             
      Hematocyst, Focal                    |                                                             3            |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                          +  +           +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Dilatation                           |                3              3  3              3                        |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2  2  3  3  2  2  3        2  2  3  2  2  2     3  3  3  2     3  1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
      Leukocytosis                         |                                              3                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                         2|             
      Hyperplasia                          |       2                                                                  |             
      Myelofibrosis                        |                   2                                                      |             
      Pigmentation, Focal                  |                                                                          |             
      Pigmentation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  M  +  M  M  +  +|             
      Congestion                           |                                                             2            |             
      Hyperplasia, Lymphoid                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |             2  2              2           2     2                 2     2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  M  +  M  +|             
      Erythrophagocytosis                  |                                                             3            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|             
                                           | 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Erythrophagocytosis                  |                                                                          |             
      Giant Cell, Multifocal               |    2                          2     1     2                 2            |             
      Hemorrhage                           |                   2                                         2            |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Congestion                           |                                                             3            |             
      Hematopoietic Cell Proliferation     |          2                                   3                       3   |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Depletion Lymphoid                   |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                 2                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Duct, Galactocele, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                                                                          |             
      Fibrous Osteodystrophy, Multifocal   |             2                       2  2           2  2     2            |             
      Hyperplasia, Multifocal              |                                                                          |             
      Metaplasia, Cartilagenous, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Head, Hemorrhage, Multifocal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Mineralization, Focal                |          2                 1     1        1     1                        |             
      Mineralization, Multifocal           |                2                             2                       2   |             
      Cerebrum, Necrosis, Focal            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                2        2  3     2                                      2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|             
                                           | 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                              2     2                     |             
      Inflammation, Granulomatous          |                      3     2                                             |             
      Inflammation                         |    1     2        3     1     2     3  1  2     2     2     2  2  2  2   |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            1                                   1        1|             
      Glands, Inflammation                 |    2                       2                    2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         | 3  2  3  2  2  2  3  2  2  2  3  2  2  2  2  2  3  2  2  2  3  2  3  2  2|             
      Olfactory Epithelium, Metaplasia     | 2  3  4  2  3  2  3  4  3  3  4  3  4  3  2  2  3  3  3  2  3  1  3  2  2|             
      Respiratory Epithelium, Hyperplasia  | 3  3  4  2  2  3  3  2  2  2  3  3  3  3  3  3  3  3  3  3  3  2  3  3  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Infarct, Focal                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                               2     1                                   2|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2  2  2     2  2  2  2  2     3     2     1  2  1        2            |             
      Nephropathy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                         1|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    3  3  2  3  2  2  2     2  2  2  2  2  2  2  2  2  2     2     2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|             
                                           | 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                         1           2                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |          2                                                               |             
      Clear Cell Focus                     |                                                                          |             
      Focal Cellular Change, Focal         |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                                   1      |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 1              1                 2                          1            |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |    2                                                                 1   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          1              2  2        1           2                        |             
      Mineralization, Focal                |                                                                          |             
      Necrosis, Focal                      |       1                                                                  |             
      Necrosis, Multifocal                 |                                                                          |             
      Bile Duct, Cytoplasmic Alteration,   |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Multifocal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                         1                                                |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2        1     1                             1                 2  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|             
                                           | 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Multifocal             |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                    1                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2        1              1  2  2  2  2        2  2              1     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Adventitia, Inflammation, Multifocal |    3                                                                     |             
      Media, Hypertrophy, Multifocal       |    4                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                  2                                       |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Suppurative                     |    2                                                                     |             
      Valve, Pigmentation, Focal           |          1  1                                2        1                  |             
      Valve, Pigmentation, Multifocal      | 1                       1     1                                1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Multifocal     | 2  3  3  3  3  3  2  3  3  2  3  2  3     3  2  3  2  2  2  3  3  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |                   2                                                      |             
      Degeneration, Focal                  |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  M  +  M  +  +  M     +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                   2                                                      |             
      Inflammation, Acute, Focal           |                1                                                         |             
      Follicle, Dilatation, Focal          |                                              3                           |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|             
                                           | 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                    X     3           X  X           X     X   |             
      Cyst, Multifocal                     |                                                                          |             
      Hematocyst, Focal                    |                      2                                                   |             
      Inflammation, Multifocal, Suppurative|                                                       2                  |             
      Metaplasia, Focal, Osseous           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |    3                                                                     |             
      Dilatation                           |                      3                                   3               |             
      Inflammation, Suppurative            |                                                       2                  |             
      Endometrium, Hyperplasia, Cystic     | 1  4  1  2  4  4        3  3  2     3           2  3  2     2  3  3  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Atrophy                              | 2                                                     2              2   |             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |       2                                               3                  |             
      Pigmentation, Focal                  |          2                                                               |             
      Pigmentation, Multifocal             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  +  +  +  +  M  +  +  +  +     M  +  +  +  +  +  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M|             
      Erythrophagocytosis                  |                                                                          |             
      Hemorrhage                           |                                           2                              |             
      Pigmentation                         |       2                 2                                            2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  M  M  +  +     +  +  M  +  +  +  +  M  +  +  M|             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|             
                                           | 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Erythrophagocytosis                  |                                                                          |             
      Giant Cell, Multifocal               |       2        2        2                       2  1                 2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                         3                                                |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                      2                                               2   |             
      Hyperplasia, Lymphoid                |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2                                                                     |             
      Duct, Galactocele, Multifocal        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                                                                   3      |             
      Fibrous Osteodystrophy, Multifocal   |                2              2                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Metaplasia, Cartilagenous, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
      Head, Hemorrhage, Multifocal         |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |                                                 3                        |             
      Hemorrhage, Multifocal               |                                           2                              |             
      Mineralization, Focal                |          1  2                       2        1     1                     |             
      Mineralization, Multifocal           |                1                                1              1         |             
      Cerebrum, Necrosis, Focal            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                            2                 2     2           2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|             
                                           | 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Granulomatous          |             2  3        3        3  3                 2                  |             
      Inflammation                         | 3  2  2  2           2     2  2  2        2     2           2     3  3   |             
      Metaplasia, Focal, Osseous           |                         1                                                |             
      Alveolar Epithelium, Hyperplasia     |                               1                                      1   |             
      Glands, Inflammation                 |       2  2                                         1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      3                                                   |             
      Inflammation                         | 3  2  3  3  3  2  2  3  2  2  2  2  3     2  2  3  3  3  2  2  2  2  2  2|             
      Olfactory Epithelium, Metaplasia     | 2  2  2  2  3  4  2  3  2  2  3  2  4     3  3  4  3  4  4  3  3  3  3  1|             
      Respiratory Epithelium, Hyperplasia  | 4  3  4  4  3  3  2  3  4  2  4  3  4     2  3  4  3  3  2  2  3  3  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Lens, Cataract                       |          3                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                1         |             
      Hemorrhage, Multifocal               |    2                                                                     |             
      Infarct, Focal                       |                                                          2               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |    2  2                                                                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2        2  2  1        2        1  2     2  2  2  2     1  2     2  2   |             
      Nephropathy                          |                      2                             2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                      2   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                   2  1                             2                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2     2  2  1        1  2  2  2              2           2  2  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +     +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  60        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      2  1.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  60        |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  62        |
      Parasite Metazoan                    |                                     X     X                 X            |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  61        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  61        |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  61        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  61        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Focal Cellular Change, Focal         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                                                                          |      2  1.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                    1                     |      7  1.1|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                      1  2|      5  1.4|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2     1           2        2     2              2         |     16  1.8|
      Mineralization, Focal                |                                              1                           |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                               3                                          |      2  3.0|
      Bile Duct, Cytoplasmic Alteration,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   3        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Mixed Cell                      |                                                       2                  |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy, Multifocal                  |                                                                          |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                            1                                             |      3  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                      2              2           1                    2  2|     17  1.6|
      Inflammation, Multifocal             |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
      Duct, Dilatation                     |                                                       3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                            2                 1                           |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2     2              2     2     2  1     2           3  2|     34  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Adventitia, Inflammation, Multifocal |                                                                          |      1  3.0|
      Media, Hypertrophy, Multifocal       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Myocardium, Inflammation, Focal,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Valve, Pigmentation, Focal           |                                                                          |      6  1.5|
      Valve, Pigmentation, Multifocal      |                                     2           1                        |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Capsule, Hyperplasia, Multifocal     |                3     3  3  3  2  3  3  3  3  2  3  3  3  3  3  2  2  2  2|     67  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Congestion, Multifocal               |                                                                          |      3  2.3|
      Degeneration, Focal                  |                                                                          |      1  3.0|
      Hypertrophy, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Congestion, Multifocal               |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +     +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Inflammation, Acute, Focal           |                                  2                                       |      2  1.5|
      Follicle, Dilatation, Focal          |                            2                                             |      2  2.5|
      Follicular Cell, Hyperplasia, Focal  |                            2     3                                       |      2  2.5|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Cyst                                 |                                        2        2  2                    2|     16  2.2|
      Cyst, Multifocal                     |                                                                3         |      1  3.0|
      Hematocyst, Focal                    |                                                                          |      2  2.5|
      Inflammation, Multifocal, Suppurative|                                                                          |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Dilatation                           |                                                    2                     |      7  2.9|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                4     3           2  3     3     2     2  3  2  3  2  2  3|     49  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukocytosis                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                                  2                                       |      4  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Pigmentation, Multifocal             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                M     +  M  +  M  +  +  +  +  +  +  M  M  M  M  +  M  +  M|  46        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +     M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  62        |
      Erythrophagocytosis                  |                            2                                             |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Pigmentation                         |                                     2                 2                  |     12  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                +     +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  52        |
      Erythrophagocytosis                  |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
      Pigmentation                         |                                     2                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +     +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +|  60        |
      Erythrophagocytosis                  |                            2                                             |      1  2.0|
      Giant Cell, Multifocal               |                      1     2        2                    2           2   |     16  1.8|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                         3                    3                           |      7  2.6|
      Hyperplasia, Lymphoid                |                3                          2        2           3         |      6  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +     +  M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +|  60        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Duct, Galactocele, Multifocal        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Fibrous Osteodystrophy, Focal        |                2                    2                          2         |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy, Multifocal   |                            2                          2  2           2   |     12  2.0|
      Hyperplasia, Multifocal              |                                  2                                       |      1  2.0|
      Metaplasia, Cartilagenous, Focal     |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                    +                           |   3        |
      Head, Hemorrhage, Multifocal         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Fibrosis, Multifocal                 |                                                                          |      1  3.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Mineralization, Focal                |                                              1                           |     11  1.3|
      Mineralization, Multifocal           |                               1                             2            |      8  1.5|
      Cerebrum, Necrosis, Focal            |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Congestion                           |                                        3                                 |      1  3.0|
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                      2     2     2  3     2     2  2  3  2     2        2|     20  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  2.0|
      Inflammation, Granulomatous          |                                  3        2  2        3        2  2      |     14  2.5|
      Inflammation                         |                3     3        2     2              1        2        3   |     35  2.1|
      Metaplasia, Focal, Osseous           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  1.0|
      Glands, Inflammation                 |                                     2                                    |      7  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
      Hemorrhage                           |                                                          2               |      2  2.5|
      Inflammation                         |                3     3  3  3  2  4  2  2  4  2  3  2  3  2  3  2  2  2  2|     68  2.4|
      Olfactory Epithelium, Metaplasia     |                2     3  2  3  3  2  4  3  3  3  2  2  3  2  3  2  3  3  1|     68  2.7|
      Respiratory Epithelium, Hyperplasia  |                2     3  2  4  2  3  3  3  2  3  2  3  3  2  3  2  2  3  2|     68  2.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  68        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   2        |
      Degeneration                         |                            4                                             |      1  4.0|
      Mineralization                       |                            4                                             |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Infarct, Focal                       |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                          2           1   |      7  1.7|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                3     2     2     2  2           3  2  2     2  2        2|     40  2.0|
      Nephropathy                          |                                     2                          2         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +     +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  62        |
      Dilatation                           |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                          2           2   |      6  1.7|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2     2           2  2  2  2     2           2  2  2      |     42  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|             
                                           | 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|             
      Dilatation                           |                2                                                         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  A  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Amyloid Deposition, Multifocal       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |          3                                                               |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                           2     2                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   2  1                 2                       2         |             
      Mineralization, Focal                |                                                                          |             
      Necrosis, Focal                      |                                           2                              |             
      Necrosis, Multifocal                 |    3                                                                     |             
      Pigmentation, Focal                  |                                                    2                     |             
      Hepatocyte, Atrophy, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                               1                                          |             
      Atrophy, Multifocal                  | 3                                                                        |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   2           2        2  2     2                       2|             
      Inflammation, Multifocal             | 2                                                                        |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Duct, Dilatation                     | 3                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|             
                                           | 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Lymphocyte                       |       2              2                          2           2            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2           2  2                 2                 2        2  2     2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                                                         2|             
      Hyperplasia, Focal                   |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                    2                     |             
      Mucosa, Cyst                         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Valve, Pigmentation, Focal           |                                                                          |             
      Valve, Pigmentation, Multifocal      |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Multifocal     | 3  3  3  3     3  3  3     3  3  3  3  3  3  3  3  3  3  3  2  2  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                              2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                3         |             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                        2                                 |             
      Degeneration, Focal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                          2               |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  M  +  +  +     M  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +|             
      Cyst, Multifocal                     |                                                                          |             
      Pars Distalis, Hyperplasia           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                   2                                                     2|             
      Inflammation, Acute, Focal           |                                                                      2   |             
      Follicle, Dilatation, Focal          |                                                                         2|             
      Follicular Cell, Hyperplasia, Focal  |                                                                         1|             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|             
                                           | 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hypertrophy,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                        +                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X              X        X  2|             
      Cyst, Multifocal                     |                                                                          |             
      Giant Cell, Multiple                 |                               2                                          |             
      Hematocyst, Focal                    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                               3                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Follicle, Hemorrhage, Focal          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                             +        +              +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      3     3                          4                  |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  2  4        2  3        2     4     4  3  3  3  3  3  3  4  2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                             +                                       |             
      Leukocytosis                         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                                                                          |             
      Hyperplasia                          |                               3                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  M  M  M     +  M  +  +  M  M  +  +  M  M  M  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                   3                    3                                 |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |          2                                   2                    2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  M  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Pigmentation                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Giant Cell, Multifocal               |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|             
                                           | 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                        4                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4        3                 3                    3                     |             
      Hyperplasia, Lymphoid                |                   3              2     3        3                        |             
      Hyperplasia, Neutrophil              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Multifocal               |          3                                                               |             
      Inflammation, Focal                  |          2                                                               |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Multifocal,            |                                                                          |             
          Polymorphonuclear                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                                     2                                    |             
      Fibrous Osteodystrophy, Multifocal   |                   2              2                    2  3               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
      Hindlimb, Infiltration Cellular,     |                                                                          |             
           Focal, Lymphocyte               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                    3  2                  |             
      Mineralization, Focal                |                                                                   2      |             
      Mineralization, Multifocal           |       2           2  2                       2     2        1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2     2        2  3              2        2     3     1        2        2|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Granulomatous          | 2     2           2  2           2  2     2     2     2                 3|             
      Inflammation                         |    2           2           2                             2           2   |             
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|             
                                           | 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Inflammation                 |                   2              2     2                    2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         | 2  2  2  2  3  2  2  3     2  3  2  2  2  2  3  3  2  2  2  2  3  2  3  3|             
      Olfactory Epithelium, Metaplasia     | 3  2  1  1  2  3  1  2     1  2  2  2  2  2  1  3  2  3  2  2  3  2  2  2|             
      Respiratory Epithelium, Hyperplasia  | 3  3  2  3  2  3  3  3     2  3  3  3  2  2  3  3  2  3  2  2  3  2  3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation, Multifocal       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Inflammation                         |                                                                          |             
      Pigmentation                         |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                              2                           |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2     2  2  2           2  2  2        2  2     2     2     2  2|             
      Nephropathy                          |                               2              2                 2         |             
      Glomerulus, Amyloid Deposition,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |    2           2  2                                                      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2        2  2        3     2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|             
                                           | 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Focal, Lymphoid         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Amyloid Deposition, Multifocal       |    3                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    1                                         1                           |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |    2                                            2                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2     3  2                             3                 2  2           2|             
      Mineralization, Focal                |       2                                                                  |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
      Hepatocyte, Atrophy, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Atrophy, Multifocal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                               2                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  2                                1  2        2  2     2        2  1   |             
      Inflammation, Multifocal             |                                                                          |             
      Acinus, Hyperplasia, Focal           |                               1                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|             
                                           | 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Lymphocyte                       |                      1              1                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2  2  2     2        2              3  2        2     3  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Mucosa, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Valve, Pigmentation, Focal           | 1     1                    2                                             |             
      Valve, Pigmentation, Multifocal      |          1     1                 1              1           2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Multifocal     | 3  3  2  3  3  3     3  2  3  3  3  3  3  3  3  3  3  3  2  3  3  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +     +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                                                          |             
      Degeneration, Focal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                             3            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Bilateral, Hyperplasia               |                               2                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
      Cyst, Multifocal                     |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Acute, Focal           |                                                 1                        |             
      Follicle, Dilatation, Focal          |          2           3                                      2            |             
      Follicular Cell, Hyperplasia, Focal  |                                                    2                     |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|             
                                           | 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hypertrophy,        |                                                                          |             
          Multifocal                       |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |    2                                            2              2         |             
      Cyst, Multifocal                     |                                                                      2   |             
      Giant Cell, Multiple                 |                                                                          |             
      Hematocyst, Focal                    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Mineralization, Multifocal           |                                                    2                     |             
      Follicle, Hemorrhage, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Dilatation                           |       4                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  3  4  4  3  3     3  2  3  3  3  3     3  2  3  3  4  3  4  4  3  4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                        +                                 |             
      Leukocytosis                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  M  +  M     +  +  +  M  +  M  M  +  M  M  M  +  M  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                           2           2           2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +     +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Erythrophagocytosis                  |                                                                          |             
      Giant Cell, Multifocal               |    2                       2              1  1        2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|             
                                           | 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                        2              2                  |             
      Hyperplasia, Lymphoid                |          2                    3                                2  2      |             
      Hyperplasia, Neutrophil              |                                                                          |             
      Hyperplasia, Plasma Cell             |                3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |             2                                                            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Multifocal               |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Multifocal,            |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy, Focal        |                2     1                                               2   |             
      Fibrous Osteodystrophy, Multifocal   |    2                       2                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Hindlimb, Infiltration Cellular,     |                                                                          |             
           Focal, Lymphocyte               |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                                          |             
      Mineralization, Focal                |                                                                         1|             
      Mineralization, Multifocal           | 1                    2                                      1     1  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  M  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2  2              2           2        1  2  2     2  3            |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Granulomatous          |    2  2  2  2              2  2                 2        2        2  3   |             
      Inflammation                         | 2                    2  2                 3  2     2           2        2|             
      Alveolar Epithelium, Hyperplasia     |                            2        1  1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|             
                                           | 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Inflammation                 | 2                                   2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Inflammation                         | 3  2  3  3  2  1     2  2  3  2  2  2  3  3  2  2  2  3  2  3  4  2  2  2|             
      Olfactory Epithelium, Metaplasia     | 3  4  2  3  1  2     2  3  3  2  2  2  4  2  2  2  2  3  2  3  3  3  2  2|             
      Respiratory Epithelium, Hyperplasia  | 3  3  3  3  2  2     3  3  3  2  2  3  3  2  2  2  2  3  2  3  3  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation, Multifocal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Inflammation                         |                                                                          |             
      Pigmentation                         |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 3  1  2  2           1     2        2  2  2  2  2        2  2  2  2  2  2|             
      Nephropathy                          |                                                                          |             
      Glomerulus, Amyloid Deposition,      |                                                                          |             
          Multifocal                       |                2                                                         |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Dilatation                           |                                  2                                       |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2     3  2  2        2  2  3           2  2  2  2  2        2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2|            |
                                           | 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Dilatation                           |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Parasite Metazoan                    |                         X                                         X      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Amyloid Deposition, Multifocal       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                           1           3  1               |      5  1.4|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                  2     2  1                              |      7  1.9|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                         3     1     2           1        1        2      |     17  1.9|
      Mineralization, Focal                |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                       3                  |      2  2.5|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Hepatocyte, Atrophy, Diffuse         |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                      +   |   3        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
      Atrophy, Multifocal                  |                                                                          |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                        2           2                     |     17  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2|            |
                                           | 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Multifocal             |                                                                          |      1  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                            1     2                 1        2            |     10  1.6|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                1  2           2     3  3  2  1  2                    1   |     30  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Mucosa, Cyst                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Valve, Pigmentation, Focal           |                   2                          1  1                        |      6  1.3|
      Valve, Pigmentation, Multifocal      |                                                    1                     |      7  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Capsule, Hyperplasia, Multifocal     |                3  3     3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  2|     66  2.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Focal Cellular Change                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Degeneration                         |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Cyst, Focal                          |                                                                          |      1  2.0|
      Degeneration, Focal                  |                            2                                             |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Bilateral, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +     +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M|  54        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2|            |
                                           | 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst, Multifocal                     |                               2                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      2  2.0|
      Inflammation, Acute, Focal           |                                                                          |      2  1.5|
      Follicle, Dilatation, Focal          |                                                          2               |      5  2.2|
      Follicular Cell, Hyperplasia, Focal  |                   2                             2                        |      4  1.8|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Follicular Cell, Hypertrophy,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Cyst                                 |                         2                 2        2  3                  |     11  2.1|
      Cyst, Multifocal                     |                                              4                           |      2  3.0|
      Giant Cell, Multiple                 |                                                                          |      1  2.0|
      Hematocyst, Focal                    |                            4  2                                          |      2  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Follicle, Hemorrhage, Focal          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Dilatation                           |                            3                                4            |      6  3.5|
      Inflammation, Suppurative            |                                                       3                  |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                3  3     4     4  2  2  2  3  4  4  4  2  2  2  3  3  2   |     56  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                       +                 +|   5        |
      Leukocytosis                         |                                                       4                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Fibrous Osteodystrophy, Focal        |                                                                   2      |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Hyperplasia, Neutrophil              |                                                       4                  |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2|            |
                                           | 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hyperplasia                          |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                +  +     +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M|  40        |
      Hyperplasia, Lymphoid                |                                        3                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +     +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  65        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                     4                                    |      4  3.3|
      Infiltration Cellular, Histiocyte    |                                                                3         |      1  3.0|
      Pigmentation                         |                2  3        2              2        2                    3|     13  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                +  +     +  M  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +|  57        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  62        |
      Erythrophagocytosis                  |                2                                                         |      1  2.0|
      Giant Cell, Multifocal               |                2  2                                                      |      8  1.8|
      Hemorrhage                           |                2                                                         |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hematopoietic Cell Proliferation     |                3                                                  2  3  3|     10  2.8|
      Hyperplasia, Lymphoid                |                         3     2     3  2                                 |     12  2.5|
      Hyperplasia, Neutrophil              |                                                       4                  |      1  4.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M|  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                   2      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Acanthosis, Multifocal               |                                                                          |      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Multifocal,            |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2|            |
                                           | 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy, Focal        |                               2     2                                    |      6  1.8|
      Fibrous Osteodystrophy, Multifocal   |                            2              2  2              3  2         |     11  2.2|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   3        |
      Hindlimb, Infiltration Cellular,     |                                                                          |            |
           Focal, Lymphocyte               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hemorrhage, Multifocal               |                                                                          |      2  2.5|
      Mineralization, Focal                |                                                                   2      |      3  1.7|
      Mineralization, Multifocal           |                         2     2     2  1     1  1  1        2  1        1|     21  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Infiltration Cellular, Lymphocyte    |                            2     3  2  3        2  2           2         |     26  2.1|
      Infiltration Cellular, Histiocyte    |                2  2                                                      |      2  2.0|
      Inflammation, Granulomatous          |                            2     3        2  2  2  2        2  2         |     28  2.1|
      Inflammation                         |                                     2  2              2  1           2   |     18  2.0|
      Alveolar Epithelium, Hyperplasia     |                                        2                       2  1      |      7  1.4|
      Glands, Inflammation                 |                               2        2                                 |      8  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |                2  3     2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2|     67  2.3|
      Olfactory Epithelium, Metaplasia     |                2  2     3  3  2  1  1  2  2  2  2  2  1  2  2  1  2  2  2|     67  2.1|
      Respiratory Epithelium, Hyperplasia  |                3  3     3  4  3  3  2  3  3  3  2  3  3  2  3  2  2  2  2|     67  2.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Glands, Dilatation, Multifocal       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                   +                  |   4        |
      Inflammation                         |                                                       4                  |      1  4.0|
      Pigmentation                         |                   3                                                      |      1  3.0|
      Lens, Cataract                       |                   3                                   3                  |      2  3.0|
      Retina, Atrophy                      |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2|            |
                                           | 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2  2     1     2  2  2  2        2        2  2  2  2      |     42  2.0|
      Nephropathy                          |                                                       2                  |      4  2.0|
      Glomerulus, Amyloid Deposition,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  63        |
      Dilatation                           |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                               3                                   2      |      5  2.2|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2        1           2     2  2  2  2     1  3  2         |     37  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|             
                                           | 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Diffuse                |    4                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Diffuse                |    4                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  A  +  +  M  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  A  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
      Inflammation, Multifocal             |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                           X                       X      |             
      Fatty Change, Focal                  |                                           2     2                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                               1                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Necrosis, Multifocal                 |                                              3                           |             
      Sinusoid, Ectasia, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                                                      |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                        1                                1|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2        2              2     1  2                 2  1        2|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|             
                                           | 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Myocardium, Inflammation, Multifocal |                                                       2                  |             
      Valve, Pigmentation, Focal           |       1                          2     2  1                              |             
      Valve, Pigmentation, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Multifocal     |    2  2  2     2        1     2        2  2  3     2  2     2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Clear Cell Focus                     |                                        X                                 |             
      Focal Cellular Change                |                                                                2         |             
      Hypertrophy, Focal                   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M  +  +  +  M  M  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               2                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Spermatocele, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|             
                                           | 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                M                                         +               |             
      Inflammation                         |                                                                          |             
      Duct, Dilatation                     |                                                          3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                  2                                       |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                  1     1                    1            |             
      Bilateral, Atrophy                   |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +                       +                  |             
      Leukocytosis                         |                               X                       X                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                 4              2                 3         |             
      Thrombosis                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  M  M  +  +  +  +  +  +  M  +  M  M  M  +  +  M  +  +  M  M  +|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Pigmentation                         |                               2                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Pigmentation                         |                            2  2        2        2     2           2      |             
      Lymphocyte, Necrosis, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  +  M  M  +  +  M  +  +  M  +  +  M  +  +  M  +  +  M  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  A  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Erythrophagocytosis                  |                                                             2            |             
      Giant Cell, Multifocal               |                                                    2        2     2     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|             
                                           | 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                               4                                          |             
      Hemorrhage                           |                            4           1                                2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute                  |                         2                    2                 2         |             
      Lymphocyte, Necrosis, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Hematopoietic Cell Proliferation     | 3     4     3                 4              3        3        4  2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  M  +  +  M  M  M  M  +  +  +  +  M  +  +  M  M  +  +  M  +  +|             
      Cyst                                 |                                                    X                     |             
      Depletion Lymphoid, Diffuse          |                4                                                         |             
      Hyperplasia, Lymphoid, Multifocal    |                                  2                                       |             
      Thymocyte, Necrosis                  |                4                                4                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |          2                 2                                             |             
      Cyst Epithelial Inclusion            |                                                    X                     |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Focal                  |                         2                                                |             
      Ulcer                                |                                  3                                       |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Edema, Diffuse  |                                                                          |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |          2                                                               |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
      Tail, Inflammation, Multifocal,      |                                                                          |             
          Necrotizing                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Developmental Malformation |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|             
                                           | 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                | 2                                                                        |             
      Mineralization, Multifocal           |          2              2                                   2  2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                       2                  |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      3   |             
      Hemorrhage                           |    2                                            2                        |             
      Infiltration Cellular, Lymphocyte    |                                  2                                       |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                   3      |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
      Glands, Dilatation                   |                                              3        2                  |             
      Glands, Inflammation                 |                                                                          |             
      Peribronchiolar, Cyst, Multifocal    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |                                                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
      Pinna, Inflammation, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +           +   |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct, Focal                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2              1        2     1  2        2           2        2|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Nephropathy                          |                      4     2                                             |             
      Pelvis, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|             
                                           | 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Dilatation, Focal      |                      3                                                   |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Mineralization, Focal  |                1  1                                                      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Distal, Dilatation                   |                                                                          |             
      Epithelium, Necrosis, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Dilatation                           |                                     2                                    |             
      Hemorrhage                           |                                                          3        3      |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute                  |                3                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|             
                             DAY ON TEST   | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|             
                                           | 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  M  +  +  +  A  +  +  +  +  +  +  +  A  +  +  A  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  M|             
      Inflammation, Diffuse                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  M|             
      Diverticulum                         |                                                                          |             
      Inflammation, Diffuse                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  A  +  A  +  A  +  A  +  +  +  +  +  +  +  A  A  +  A  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  M|             
      Inflammation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  A  +  +  +  A  +  A  +  A  +  +  A  +  +  +  +  +  +  A  A  +  A  M|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Necrosis, Multifocal                 |                               3                                          |             
      Sinusoid, Ectasia, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
      Atrophy                              |                                  3  2                                    |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                           2  1                           |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                 1                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                  2           2        2           2      |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|             
                             DAY ON TEST   | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|             
                                           | 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Myocardium, Inflammation, Multifocal |                                                                          |             
      Valve, Pigmentation, Focal           |                                                                      1   |             
      Valve, Pigmentation, Multifocal      |                   2                             2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Capsule, Hyperplasia, Multifocal     | 2        2  2  3        1  2  1     2  2  2  2  2     2  2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Congestion            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Spermatocele, Focal                  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|             
                             DAY ON TEST   | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|             
                                           | 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                +         |             
      Inflammation                         |                                                                          |             
      Duct, Dilatation                     |                                                                2         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute                  | 2                             3        3                    3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Dilatation                           |                               2                                          |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Mineralization, Focal                |          1                                                               |             
      Bilateral, Atrophy                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                    2  2                    2                           |             
      Thrombosis                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  +  +  +  M  M  M  +  +  +  M  M  M  M  +  +  M  +  +  M  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Pigmentation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Pigmentation                         | 1        2                                   2                           |             
      Lymphocyte, Necrosis, Multifocal     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  M  +  M  M  M  M  M  M  +  M  +  M  +  M  +  +  +  M  M  +  M  M|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Pigmentation                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M|             
      Angiectasis                          |                                                                          |             
      Erythrophagocytosis                  |                                        2           2              2      |             
      Giant Cell, Multifocal               |                            2              2     2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|             
                             DAY ON TEST   | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|             
                                           | 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                   2      |             
      Hemorrhage                           |          3                 2              2              2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Lymphocyte, Necrosis, Multifocal     |             1                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                    2                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Necrosis                 |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  M  M  +  M  +|             
      Cyst                                 |                                              X                           |             
      Depletion Lymphoid, Diffuse          |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |             
      Thymocyte, Necrosis                  | 2           2                 3        3                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Focal                  |       4     2     3                                                      |             
      Ulcer                                |       2  3                                                               |             
      Prepuce, Inflammation, Chronic Active|                      2                                                   |             
      Prepuce, Ulcer                       | 3                                                              4     4   |             
      Subcutaneous Tissue, Edema, Diffuse  |                                                                          |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |             3                                                            |             
      Tail, Inflammation, Multifocal,      |                                                                          |             
          Necrotizing                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Developmental Malformation |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|             
                             DAY ON TEST   | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|             
                                           | 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                                                          |             
      Mineralization, Multifocal           |             1           1  2  1                 2  2  1           2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3     3        3                    3                                   2|             
      Hemorrhage                           |                                        2        2                        |             
      Infiltration Cellular, Lymphocyte    |                                                       2                  |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Glands, Dilatation                   |                                                                          |             
      Glands, Inflammation                 |          2                 2                 1     1                     |             
      Peribronchiolar, Cyst, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |                                                                         3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Inflammation, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Lens, Cataract                       |                                                                         3|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Multifocal               |                                     2                                    |             
      Hydronephrosis                       |                                                                          |             
      Infarct, Focal                       |                                                          2               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2                                            3  2  2  2  2               |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute, Multifocal      |                      3                 2                                 |             
      Nephropathy                          |                                                       2           1      |             
      Pelvis, Inflammation, Acute          |                         2     2                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|             
                             DAY ON TEST   | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|             
                                           | 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Dilatation, Focal      |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Mineralization, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Distal, Dilatation                   |                                                                          |             
      Epithelium, Necrosis, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M|             
      Dilatation                           |                                        3                                 |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Acute                  |                         3                                                |             
      Inflammation, Chronic Active         | 4                    3                                                   |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3|            |
                                           | 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  66        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  56        |
      Inflammation, Diffuse                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  A  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  58        |
      Diverticulum                         |                                                    3                     |      1  3.0|
      Inflammation, Diffuse                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  A  +  A  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  A  +  A  +|  51        |
      Inflammation, Multifocal             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Basophilic Focus                     |                                                                          |      2     |
      Fatty Change, Focal                  |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                         2|      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                  4                                       |      1  4.0|
      Necrosis, Multifocal                 |                            3              2                              |      4  2.8|
      Sinusoid, Ectasia, Focal             |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   1        |
      Fat, Necrosis, Focal                 |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Atrophy                              |                                                                          |      3  2.3|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                         2                                                |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                         1|      3  1.3|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3|            |
                                           | 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Lymphocyte                      |                                                                         2|     13  1.8|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  63        |
      Inflammation, Focal                  |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  62        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Inflammation, Acute, Focal           |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Myocardium, Inflammation, Multifocal |                                                                          |      1  2.0|
      Valve, Pigmentation, Focal           |                                                                          |      5  1.4|
      Valve, Pigmentation, Multifocal      |                                                                   2     1|      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Capsule, Hyperplasia, Multifocal     |                3     2  2        2  2     2  2     2  2  2  2  2  2  2  2|     45  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Atrophy, Focal                       |                                                                         3|      1  3.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Focal Cellular Change                |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Cyst, Focal                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  M  M  M  +  +  M  +  M  +  +  +  M  +  M  +  +  +|  52        |
      Pars Distalis, Congestion            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3|            |
                                           | 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Spermatocele, Focal                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                 +                        |   2        |
      Inflammation, Multifocal             |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                        +                             +   |   4        |
      Inflammation                         |                                                                      4   |      1  4.0|
      Duct, Dilatation                     |                                        3                                 |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Inflammation, Acute                  |                                           3  2     3                 3   |      8  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  66        |
      Dilatation                           |                                        2                 2               |      3  2.0|
      Inflammation, Focal                  |                                              3           2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Mineralization, Focal                |                                                                          |      4  1.0|
      Bilateral, Atrophy                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                       +                  |   3        |
      Leukocytosis                         |                                                       3                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Hyperplasia                          |                                                       2                  |      9  2.4|
      Thrombosis                           |                                                          X               |      1     |
      Myeloid Cell, Hyperplasia            |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                +  M  +  M  +  M  +  +  +  M  +  M  +  +  +  +  M  +  +  M|  38        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Pigmentation                         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M|  61        |
      Angiectasis                          |                                                                      2   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3|            |
                                           | 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Pigmentation                         |                            2           2                             2   |     12  1.9|
      Lymphocyte, Necrosis, Multifocal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                +  M  +  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +|  37        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Pigmentation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  57        |
      Angiectasis                          |                                              3                           |      1  3.0|
      Erythrophagocytosis                  |                                     2                             2     2|      7  2.0|
      Giant Cell, Multifocal               |                      2              2        2              2            |     11  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                       3                  |      3  3.0|
      Hemorrhage                           |                                           3  3        3  2     2         |     12  2.4|
      Hyperplasia, Lymphoid                |                         2                                                |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                      3   |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Lymphocyte, Necrosis, Multifocal     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                2     3  3  4        3     2  3  3     3                 3|     20  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                  4                                       |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Lymphocyte, Necrosis                 |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  M  +  +  +  M  +  M  M  +  +  +  +  M  +  +  +  +  M  +|  47        |
      Cyst                                 |                                                                          |      2     |
      Depletion Lymphoid, Diffuse          |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |      1  2.0|
      Thymocyte, Necrosis                  |                         2                                      3         |      8  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  +|   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Acanthosis, Focal                    |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3|            |
                                           | 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Inflammation, Focal                  |                                           3                              |      5  2.8|
      Ulcer                                |                                              4                           |      4  3.0|
      Prepuce, Inflammation, Chronic Active|                                                                          |      1  2.0|
      Prepuce, Ulcer                       |                                                                          |      3  3.7|
      Subcutaneous Tissue, Edema, Diffuse  |                                           3                              |      1  3.0|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
      Tail, Inflammation, Multifocal,      |                                                                          |            |
          Necrotizing                      |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Vertebra, Developmental Malformation |                                              X                           |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Mineralization, Focal                |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                2     2              3        2           2        2      |     18  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                         2              2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Congestion                           |                               2        3                             3   |      9  2.8|
      Hemorrhage                           |                                                                          |      4  2.0|
      Infiltration Cellular, Lymphocyte    |                                                 1                        |      3  1.7|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                          1               |      2  1.5|
      Glands, Dilatation                   |                                                                          |      2  2.5|
      Glands, Inflammation                 |                            1                                2     1      |      7  1.4|
      Peribronchiolar, Cyst, Multifocal    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3|            |
                                           | 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Congestion, Multifocal               |                               2                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Glands, Dilatation                   |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   2        |
      Pinna, Inflammation, Focal           |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Lens, Cataract                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Congestion, Multifocal               |                                                                          |      1  2.0|
      Hydronephrosis                       |                                              3                           |      1  3.0|
      Infarct, Focal                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                         2                             2     2            |     17  1.9|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Inflammation, Acute, Multifocal      |                                                                          |      2  2.5|
      Nephropathy                          |                                              2                          1|      6  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      3  2.0|
      Renal Tubule, Dilatation, Focal      |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Focal     |                            3                                             |      1  3.0|
      Renal Tubule, Mineralization, Focal  |                                              2     2                     |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                    +                     |   1        |
      Distal, Dilatation                   |                                                    3                     |      1  3.0|
      Epithelium, Necrosis, Multifocal     |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  A  +|  60        |
      Dilatation                           |                      3     2        2     3     2                        |      7  2.4|
      Hemorrhage                           |                                                                          |      2  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                  3                                       |      1  3.0|
      Inflammation, Acute                  |                                              2                           |      3  2.7|
      Inflammation, Chronic Active         |                                                    3                     |      3  3.3|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Multifocal                      |                                                    2                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|             
                                           | 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  M  +  +  M  M                 +                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +     A  +  A  +  +  +  A                 +                           |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +     +  +  A  +  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A     +  +  A  A  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +     +  +  A  +  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  M     +  +  A  A  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A     +  +  A  A  +  +  A                 +                           |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A     A  +  A  A  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  M     +  +  A  A  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  M     +  +  A  A  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +        +     +  +                       +|             
      Degeneration, Focal                  |                                                                          |             
      Necrosis, Focal                      |                                                 2                        |             
      Necrosis, Multifocal                 |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +                    +                           |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +              M                           |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                         2                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +     +  +  +  +  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +     +  +  +  +  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +     +  +  +  +  +  +  A                 +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +  M                 +                    +     +|             
      Capsule, Hyperplasia, Multifocal     |                         2                                         2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  M                 +                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  M                 +                    +     +|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +                    +                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M     +  +  M  M  +  +  M                 +                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +     +  +  M  M  +  M  M                 +                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  M  +  +  +  A                 +                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|             
                                           | 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +  +                 +                           |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +        +                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +  M                 +                           |             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Inflammation, Acute                  |    2           2                                                         |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  M  +  +  +  +                 +                           |             
      Dilatation                           | 2                                                                        |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +  +                 +  +                        |             
      Atrophy                              |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +                 +                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +                 +                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +     M  +  +  M  M  M  M                 M                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Necrosis                 |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M     +  +  +  +  +  +  +                 M                           |             
      Pigmentation                         |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M     M  M  M  M  M  M  +                 +                           |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  M     +  +  M  M  M  +  M                 M                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  A                 +                           |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |          2     2        2                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M     M  +  M  M  M  M  M                 M                           |             
      Thymocyte, Necrosis                  |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M  M  M  M  M  M  M                 M                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +              +  +                        |             
      Inflammation, Focal                  |                2                             4                           |             
      Ulcer                                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|             
                                           | 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +                 +  +                        |             
      Vertebra, Fracture Healed            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                       +                           |             
      Inflammation, Chronic                |                      4                       4                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +                 +                           |             
      Mineralization, Multifocal           |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  A                 +                           |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +|             
      Congestion                           | 3                                                                        |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       2  2     2                 1                                2      |             
      Inflammation, Granulomatous          |             2                          2        2                 3  2  3|             
      Inflammation                         |                   2                 3     3  2                       2   |             
      Alveolar Epithelium, Hyperplasia     |                                           1                              |             
      Glands, Inflammation                 |                                        1                          2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +|             
      Inflammation                         |    2     2  2  1  2  1  2  2  2  3  2  2  2  1  3                 2  3  3|             
      Olfactory Epithelium, Metaplasia     |    2     2  2  2  2  1  3  2  2  4  2  3  2     3                 3  3  3|             
      Respiratory Epithelium, Hyperplasia  |    3     1  3  2  3  1  3  2  3  3  2  3  2     3                 3  3  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  M  +  +  +  +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +                       +                           |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +                 +  +                        |             
      Degeneration                         |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2        2                                                            |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Nephropathy                          |          2                                                               |             
      Renal Tubule, Dilatation, Focal      |                                                                          |             
      Renal Tubule, Mineralization, Focal  |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  A  +  +  +  M                 +                           |             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|             
                                           | 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |          3                                                               |             
      Serosa, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|             
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +                       +                                    |             
      Serosa, Fibrosis                     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +                 +  +        +     +                    +           +   |             
      Degeneration, Focal                  |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                     3                                    |             
      Serosa, Fibrosis                     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|             
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                                     +                                    |             
      Serosa, Inflammation, Chronic        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                     +                                    |             
      Serosa, Inflammation, Chronic        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                                     +                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Serosa, Inflammation, Chronic        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +  +              +                       +            |             
      Dilatation                           |                                                                          |             
      Serosa, Inflammation, Chronic        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Testes                                  |                      +                                                   |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                           +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                             +            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +                 +  +                       +        +   |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             3            |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
      Capsule, Fibrosis                    |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +           +                                      +            |             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|             
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Vertebra, Fracture Healed            |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                           +            |             
      Inflammation, Chronic                | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |          2     2  2  2                                1  2               |             
      Inflammation, Granulomatous          | 3                          2                 2  2        2        2  2   |             
      Inflammation                         |    3        2           2              2                    3  2        2|             
      Alveolar Epithelium, Hyperplasia     | 1                       2        2                             2  2      |             
      Glands, Inflammation                 |                            2                 2  3        3     2  2  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3  2     3  3  2  2  2  2  3  3  3  3  2  3  2  3  2  3  1  3  2  2  2  2|             
      Olfactory Epithelium, Metaplasia     | 3  2     2  3  2  3  3  4  3  3  3  2  3  2  2  3  2  3  3  3  3  2  2  3|             
      Respiratory Epithelium, Hyperplasia  | 3  2     3  3  2  3  3  3  3  3  4  2  3  2  2  3  2  2  2  3  2  3  3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Degeneration                         |                               4                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                   +  +                                                  +|             
      Degeneration                         |                   4                                                      |             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Nephropathy                          |                                                                         3|             
      Renal Tubule, Dilatation, Focal      |                                                                          |             
      Renal Tubule, Mineralization, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                     +                             +      |             
      Dilatation                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|             
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Serosa, Inflammation, Chronic        |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4|            |
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9|      L     |
                                           | 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                   +      |   7        |
      Dilatation                           |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   8        |
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +           +     +     +           +     +           +     +|  33        |
      Degeneration, Focal                  |                                                                         2|      1  2.0|
      Necrosis, Focal                      |                                                                         1|      2  1.5|
      Necrosis, Multifocal                 |                                                 2                        |      2  2.5|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                          +               |  10        |
      Inflammation, Chronic Active, Diffuse|                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                   +      |  11        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                            +                                      +      |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                            +                                      +      |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                            +                                      +      |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  11        |
      Capsule, Hyperplasia, Multifocal     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  11        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4|            |
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9|      L     |
                                           | 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                                                          |   1        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  11        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |   1        |
      Duct, Dilatation                     |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                     +                                    |  11        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                              +           +        +      |  16        |
      Dilatation                           |                                                                   2      |      2  2.0|
      Serosa, Inflammation, Chronic        |                                                          2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  12        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +              +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |             +              +                                             |   5        |
      Hyperplasia, Lymphoid                |                            4                                             |      1  4.0|
      Lymphocyte, Necrosis                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   8        |
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   4        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +                          +              +           +      |  18        |
      Depletion Lymphoid                   |                                                                   2      |      1  2.0|
      Hematopoietic Cell Proliferation     |             3                                                            |      5  2.4|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   1        |
      Thymocyte, Necrosis                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4|            |
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9|      L     |
                                           | 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                         +        +  +     +                              |  21        |
      Inflammation, Focal                  |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  11        |
      Vertebra, Fracture Healed            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  10        |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |       2                                            1                 3   |      3  2.0|
      Infiltration Cellular, Histiocyte    |          2                                                               |     12  1.8|
      Inflammation, Granulomatous          |             3        2  2           3                                1  2|     19  2.2|
      Inflammation                         | 1              3  2        3  2  3        2           2        3         |     21  2.3|
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |      7  1.7|
      Glands, Inflammation                 |       2              2        3              2        2                  |     14  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Inflammation                         | 2  2  2  3  2  3  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  3|     67  2.2|
      Olfactory Epithelium, Metaplasia     | 2  2  3  3  2  3  3  3  3  2  3  3  2  4  2  2  2  2  2  2  2  2  3  3  3|     66  2.5|
      Respiratory Epithelium, Hyperplasia  | 2  2  3  3  2  3  3  4  3  2  2  3  2  3  2  2  2  2  2  2  2  3  3  3  3|     66  2.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Degeneration                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |   1        |
      Cyst, Multiple                       |                                                                X         |      1     |
      Inflammation, Chronic                |                                                                3         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4|            |
                                           | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9|      L     |
                                           | 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                     +                             +      |  16        |
      Degeneration                         |                                                                          |      1  4.0|
      Hydronephrosis                       |                                     3                                    |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
      Inflammation, Acute, Multifocal      |                                                                   3      |      1  3.0|
      Nephropathy                          |                                                                          |      2  2.5|
      Renal Tubule, Dilatation, Focal      |                                     3                                    |      1  3.0|
      Renal Tubule, Mineralization, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                 +  +              +                    +        +      |  16        |
      Dilatation                           | 3                 3  3              3                             3      |      6  3.0|
      Inflammation, Chronic Active         |                                                          2               |      2  2.5|
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|             
                                           | 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  A  +  +  +  M  +  +  M  +  M  +  M  +     +|             
      Epithelium, Hyperplasia, Focal,      |                                                                          |             
          Papillary                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Focal, Lymphoid         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Submucosa, Dilatation, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     |       X                                            X        X            |             
      Basophilic Focus, Multifocal         |                                           X                              |             
      Clear Cell Focus                     |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                     1                                    |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Mixed Cell Focus                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                         2           1                                   2|             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |          2           2              1           2                 2     2|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2                       3        1                          2            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|             
                                           | 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Focal                   |                                           3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Acute, Focal           |                                                                          |             
      Mineralization, Focal                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Valve, Pigmentation, Focal           |    2     2                                                               |             
      Valve, Pigmentation, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Capsule, Hyperplasia, Focal          |                            2                             2               |             
      Capsule, Hyperplasia, Multifocal     | 2  2  2           2  2  2           2  2  3  2  2  2  2     2  2        2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                    X                     |             
      Focal Cellular Change                |                                     X                                    |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst, Focal                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M     +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Granuloma Sperm                      |                                                       3                  |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Duct, Dilatation, Focal              |                   3                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|             
                                           | 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                        3                                 |             
      Mineralization, Focal                |                                                                          |             
      Thrombosis, Focal                    |                                                                          |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis, Focal                   |                                  3                                       |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis, Focal                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +     +|             
      Giant Cell, Multifocal               |                                                                          |             
      Hyperplasia, Lymphoid                |                         3                                                |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  M  +  +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  M     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Erythrophagocytosis                  |          2                                                     2         |             
      Giant Cell, Multifocal               |                                        2              2  2        2      |             
      Hemorrhage                           |                         2                                2               |             
      Hyperplasia, Lymphoid                | 4                       3                                                |             
      Lymphocyte, Necrosis, Multifocal     |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Lymphoid                | 2                                         2                              |             
      Lymphocyte, Necrosis                 |                            2                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Cyst, Multifocal                     |                                                             X            |             
      Thymocyte, Necrosis                  |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acanthosis, Focal                    |                                                                          |             
      Inflammation, Focal                  |                3                                                         |             
      Sweat Gland, Ectasia, Multifocal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|             
                                           | 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mineralization, Focal                |    1                                                                     |             
      Mineralization, Multifocal           | 2        2                                2                 2  2  2     2|             
      Olfactory Lobe, Hemorrhage, Focal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hemorrhage                           |    2        2                                               2            |             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
      Infiltration Cellular, Histiocyte    | 1              1  1  2     2  2                                          |             
      Inflammation, Granulomatous          |       3                          3                                       |             
      Inflammation                         |                2     1           3  3     3  1        1     2  2  3     2|             
      Alveolar Epithelium, Hyperplasia     | 3     3                       1                                1         |             
      Glands, Inflammation                 |                         2                             2                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         | 2  2  3  2  2  2  4  2  4  2  3  3  3  2  2  3  3  2     2  2  3  2     2|             
      Olfactory Epithelium, Metaplasia     | 3  2  2  4  3  3  3  3  3  3  2  2  2  3  2  3  3  2  2  3  3  2  3     3|             
      Respiratory Epithelium, Hyperplasia  | 2  3  3  2  2  2  4  4  3  3  3  3  3  2  2  3  3  3  3  3  2  2  2     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Glands, Dilatation                   |                                                                          |             
      Glands, Infiltration Cellular, Focal,|                                                                          |             
           Lymphocyte                      |                                                                          |             
      Glands, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                    +                                      +|             
      Dysplasia, Multifocal                |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infarct, Focal                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                        2     2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|             
                                           | 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                2     1  2        2  1           2  2           2  1      |             
      Nephropathy                          |       2                                   2                    2         |             
      Renal Tubule, Dilatation, Focal      |       3                                                                  |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Mineralization, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Dilatation                           |                            3                                             |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                        1        2           2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal,      |                                                                          |             
          Papillary                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Dilatation, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                   X      |             
      Basophilic Focus, Multifocal         |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Fibrosis, Focal                      |                3                                                         |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                    2                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                              2                           |             
      Mineralization, Focal                |                3                                                         |             
      Mixed Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                         2                                                |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Focal                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                         2                                                |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2                                               2  1  2  1        1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                1         |             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Valve, Pigmentation, Focal           |    2                          2                       2                  |             
      Valve, Pigmentation, Multifocal      |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 2  2  3     2  3  2  2     2  2  2  2  2  2     2  3  2  2  2  2     3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Focal Cellular Change                |                2                                                         |             
      Hypertrophy, Focal                   |             1                       2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Polymorphonuclear                |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                                                   2     X|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Follicular Cell, Hyperplasia, Focal  |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       | 2                                                                        |             
      Duct, Dilatation, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Thrombosis, Focal                    |                                                                          |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Hemorrhage, Focal                    |                            2                                             |             
      Hyperplasia                          |                                           2                              |             
      Myelofibrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Giant Cell, Multifocal               |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Pigmentation                         |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2                                3                        |             
      Pigmentation                         |                      2  2                                               1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  M  M  +  +  +  +  +  +  M  M  +  M  M  +  +  M  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |       2                       2        2     2     2                 2  2|             
      Giant Cell, Multifocal               |       2     2                 2  2  2  2  2  2     3              2  2  2|             
      Hemorrhage                           |       2     2     2        2  2              1     2                     |             
      Hyperplasia, Lymphoid                |                                                 3  3                     |             
      Lymphocyte, Necrosis, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                            X                  |             
      Cyst, Multifocal                     |                                                                2         |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Sweat Gland, Ectasia, Multifocal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |             1     2                             2                    1   |             
      Mineralization, Multifocal           | 1     2  2     2        1  2        2  2  1           2  2  2  2        2|             
      Olfactory Lobe, Hemorrhage, Focal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1     2                                                            |             
      Infiltration Cellular, Lymphocyte    | 3                                               2                        |             
      Infiltration Cellular, Histiocyte    |       1                 2     2              2              1            |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation                         |          2  2  3  3     2        2                 2           2        3|             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
      Glands, Inflammation                 | 2                    1                 2  2                 1        1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         | 4  4  4  3  3  2  2  4  3  2  2  4  2  3  2  2  3  2  3  2  4  2  2  2  3|             
      Olfactory Epithelium, Metaplasia     | 3  4  3  3  3  3  3  3  2  2  3  2  3  3  3  3  3  3  3  3  2  3  2  2  3|             
      Respiratory Epithelium, Hyperplasia  | 4  4  3  4  3  3  3  4  3  2  3  3  4  4  3  2  3  3  4  3  3  3  2  3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                     2                                    |             
      Glands, Infiltration Cellular, Focal,|                                                                          |             
           Lymphocyte                      |                                                 2                        |             
      Glands, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Dysplasia, Multifocal                |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Focal                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  1  1  2                             1        2  2  2     2     2     2|             
      Nephropathy                          |                                                    2  2                  |             
      Renal Tubule, Dilatation, Focal      |                2                                      2                  |             
      Renal Tubule, Hyperplasia, Focal     |       1        2                    1                                    |             
      Renal Tubule, Mineralization, Focal  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2                                                                 1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  61        |
      Epithelium, Hyperplasia, Focal,      |                                                                          |            |
          Papillary                        |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  65        |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  65        |
      Parasite Metazoan                    |                   X                                                  X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  64        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  M  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  64        |
      Submucosa, Dilatation, Focal         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Basophilic Focus                     |                   X                                                      |      5     |
      Basophilic Focus, Multifocal         |                                                                          |      1     |
      Clear Cell Focus                     |                                                          X               |      1     |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                                  1     1                                 |      2  1.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                1        2|      3  1.7|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                    X                     |      2     |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  66        |
      Atrophy                              |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      3  1.7|
      Inflammation, Focal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                         1                                                |      8  1.8|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                          2     1     2  2|     14  1.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  65        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  65        |
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Mineralization, Focal                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Valve, Pigmentation, Focal           |                                                       2  2               |      7  2.0|
      Valve, Pigmentation, Multifocal      |                2                                               2         |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +  +     +  +  M  +     +  +  +  +  +  +  +  +  +  +|  65        |
      Capsule, Hyperplasia, Focal          |                                  2                                       |      3  2.0|
      Capsule, Hyperplasia, Multifocal     |                2     1  1     2        1        2  2  2  2     2  2  2   |     49  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +  +     +  +  M  +     +  +  +  +  +  +  +  +  +  +|  65        |
      Cyst                                 |                                                                          |      1     |
      Focal Cellular Change                |                                                                2         |      3  2.0|
      Hypertrophy, Focal                   |                                                             2     2      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +  +     +  +  M  +     +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  66        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  M  +  +|  62        |
      Cyst, Focal                          |                   2                                                      |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  +     +  +  +  +     M  +  +  +  +  +  +  +  M  M|  58        |
      Cyst                                 |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  66        |
      Cyst                                 |                                                                          |      1     |
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Granuloma Sperm                      |                                                 3                        |      2  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Duct, Dilatation, Focal              |                                                          2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Angiectasis, Focal                   |                                                 2                        |      1  2.0|
      Atrophy                              |                                                                          |      1  3.0|
      Mineralization, Focal                |                                                          2  2            |      2  2.0|
      Thrombosis, Focal                    |                                                 2                        |      1  2.0|
      Interstitial Cell, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Myelofibrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                +  M  M  M     M  +  +  +     M  +  +  +  +  +  +  +  +  M|  57        |
      Giant Cell, Multifocal               |                                                       2  2               |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Pigmentation                         |                                                             2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +  +  +     +  +  M  +     +  +  +  +  +  +  M  +  +  +|  59        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Pigmentation                         |                                        2           1                     |      5  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                +  +  +  +     +  +  M  M     M  M  +  +  M  M  M  M  +  +|  43        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  66        |
      Erythrophagocytosis                  |                2     2           2                                      3|     13  2.1|
      Giant Cell, Multifocal               |                2              2  1              2  2     2     2        2|     24  2.0|
      Hemorrhage                           |                2  1  2  3                       2                 2     2|     16  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      4  3.3|
      Lymphocyte, Necrosis, Multifocal     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Lymphocyte, Necrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  +     +  +  +  +     +  +  M  +  +  +  +  +  +  +|  63        |
      Cyst                                 |                                                                2     2   |      4  2.0|
      Cyst, Multifocal                     |                                                                          |      2  2.0|
      Thymocyte, Necrosis                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M  M  M  M     M  M  M  +     M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Acanthosis, Focal                    |                                              2                           |      1  2.0|
      Inflammation, Focal                  |                                                                          |      1  3.0|
      Sweat Gland, Ectasia, Multifocal     |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Mineralization, Focal                |                                              1              2            |      7  1.4|
      Mineralization, Multifocal           |                                        2           1     2     1         |     25  1.8|
      Olfactory Lobe, Hemorrhage, Focal    |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  64        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Hemorrhage                           |                                                                          |      5  1.8|
      Infiltration Cellular, Lymphocyte    |                                                                         2|      4  2.3|
      Infiltration Cellular, Histiocyte    |                                                                          |     11  1.5|
      Inflammation, Granulomatous          |                2                                                         |      3  2.7|
      Inflammation                         |                   2  3  1                          1  1  1        2     2|     28  2.0|
      Alveolar Epithelium, Hyperplasia     |                                  1                 1              2      |      8  1.8|
      Glands, Inflammation                 |                   2     2     2  2     2        2                        |     14  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Hemorrhage                           |                               2                                          |      1  2.0|
      Inflammation                         |                2  2  2  3     3  2  2  4     2  2  3  2  2  2  3  2  2  3|     66  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Metaplasia     |                2  3  3  3     3  2  2  3     3  2  3  4  2  2  3  3  2  2|     67  2.7|
      Respiratory Epithelium, Hyperplasia  |                2  2  2  4     3  2  3  4     3  2  2  2  2  2  4  4  3  3|     67  2.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Glands, Dilatation                   |                                                                          |      1  2.0|
      Glands, Infiltration Cellular, Focal,|                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Glands, Inflammation, Focal,         |                                                                          |            |
          Suppurative                      |                                        2                                 |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   4        |
      Dysplasia, Multifocal                |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  67        |
      Infarct, Focal                       |                                                          2               |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                1                                                         |      3  1.7|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                   1  2  1     2  1                 1     2  2  2     1   |     30  1.6|
      Nephropathy                          |                               1        1                                2|      8  1.8|
      Renal Tubule, Dilatation, Focal      |                                                                          |      3  2.3|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      3  1.3|
      Renal Tubule, Mineralization, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|  66        |
      Dilatation                           |                                                                3        3|      3  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                      1   |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Prolapse                             |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multifocal         |                                                                          |             
      Cyst, Focal                          |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                             2            |             
      Degeneration, Focal                  |                                                          3               |             
      Eosinophilic Focus                   |                                                             X            |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                              1                 1         |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Infarct, Focal                       |                                                          4               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                               1                    1                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Thrombosis, Multifocal               |                                                          3               |             
      Hepatocyte, Cytomegaly, Focal        |                                                                          |             
      Sinusoid, Ectasia, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Lymphocyte                      |                                                             1           1|             
      Inflammation, Focal                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Multifocal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                    1  2                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                          1  1           2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Multifocal |                                                                          |             
      Valve, Pigmentation, Focal           |                                                                   1     1|             
      Valve, Pigmentation, Multifocal      |                                                                          |             
      Ventricle, Thrombosis, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |                                                             2            |             
      Capsule, Hyperplasia, Multifocal     | 2  2  2  2        2  2  2  2  2  2     2  2     2  2  2  2     2  2  3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |                                                                          |             
      Giant Cell, Multifocal               |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                                                          |             
      Ectopic Tissue                       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Follicle, Dilatation, Focal          |                                              2                           |             
      Follicular Cell, Hyperplasia, Focal  |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                         3                                                |             
      Inflammation, Focal                  |                                                 1                        |             
      Spermatocele, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +                                      +     +         |             
      Hyperplasia                          |                                                          2               |             
      Inflammation                         |                                                                3         |             
      Duct, Dilatation                     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                                                      |             
      Mineralization, Focal                |                2        2                                                |             
      Bilateral, Atrophy                   |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        2                                 |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia                          | 3     3  2           3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  +  M  M  M  +  +  +  +  M  +  +  M  M  M  +  +  M  +  +  +|             
      Giant Cell, Multifocal               |                                                                          |             
      Pigmentation                         |                                                          1           2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |       2                                                        1     2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |       2                    2  2     2                    2               |             
      Giant Cell, Multifocal               |                               2     2        2  2     1     2        2   |             
      Hemorrhage                           |                               2     2  3                 2               |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Hematopoietic Cell Proliferation     |          3           3                 2     2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cyst, Multifocal                     |                                                                2         |             
      Ectopic Parathyroid Gland, Focal     |                                                                          |             
      Epithelial Cell, Cytoplasmic         |                                                                          |             
          Alteration, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                2         |             
      Lymphatic, Dilatation                |                   3                                            3         |             
      Subcutaneous Tissue, Angiectasis     |                2                                                         |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                              1                           |             
      Mineralization, Multifocal           |                2           2              2                       2  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                               2                       2                  |             
      Infiltration Cellular, Histiocyte    |          1  2                                                     2      |             
      Inflammation, Granulomatous          |                      3                    3  2  2        2               |             
      Inflammation                         |    2           2                       2                    3        1   |             
      Alveolar Epithelium, Hyperplasia     |                                  1     1                                 |             
      Glands, Inflammation                 |                            3                                   3         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3  4  3  2  3  3  4  4  2  4  3  3  2  2  2  3  2  2  3  2  2  2  3  2  3|             
      Olfactory Epithelium, Metaplasia     | 2  2  2  1  2  2  2  2  3  3  3  4  3  3  2  2  2  2  4  2  2  1  3  2  2|             
      Respiratory Epithelium, Hyperplasia  | 2  4  2  3  2  3  3  2  2  3  2  4  4  2  2  3  3  3  3  2  3  2  2  3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Inflammation, Focal          |                                                                          |             
      Iris, Hyperplasia, Multifocal,       |                                                                          |             
          Melanocyte                       |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                      3                                                   |             
      Infarct, Focal                       |                                              2                           |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2                 2     2           1     2     2  2  2               |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Nephropathy                          | 2                                                                       1|             
      Renal Tubule, Giant Cell, Focal      |                                                                          |             
      Renal Tubule, Mineralization, Focal  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                         1|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|             
                                           | 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Prolapse                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                 X                        |             
      Clear Cell Focus, Multifocal         |                                                                          |             
      Cyst, Focal                          |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Focal                  |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                   2                                                      |             
      Hemorrhage, Focal                    |                                                                          |             
      Infarct, Focal                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                               2                                          |             
      Mixed Cell Focus                     |                                                 X                        |             
      Necrosis, Multifocal                 |                                                                          |             
      Thrombosis, Multifocal               |                                                                          |             
      Hepatocyte, Cytomegaly, Focal        |                                                                          |             
      Sinusoid, Ectasia, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   4           4                             2            |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05110-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 04/28/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:51:23  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|             
                                           | 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Lymphocyte                      |                   2                                                      |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Multifocal                  |                                                                         2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                            2                       2                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2                    2        2              2  2              2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Multifocal |                   2                                                      |             
      Valve, Pigmentation, Focal           |                      2                          2                        |             
      Valve, Pigmentation, Multifocal      |                2                                                        2|             
      Ventricle, Thrombosis, Focal         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |    2                                                                     |             
      Capsule, Hyperplasia, Multifocal     | 2     2  3  3  2  2  3  2  2  2  2  2  2  2           2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |    2                                                                     |             
      Giant Cell, Multifocal               |          2                                                               |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst, Focal                          | 2                                                                        |             
      Ectopic Tissue                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Follicle, Dilatation, Focal          |                            2                                             |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |