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TDMS Study 05111-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       1,2,3-TRICHLOROPROPANE


NTP Experiment-Test: 05111-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: GAVAGE                                                                                                     Time: 08:34:18




       Facility:  TSI Mason Research

       Chemical CAS #:  96-18-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                            9            6                                     
  Early Deaths                                                                                                                      
    Moribund                                           8           34           37           48                                     
    Dead                                               1            3            4            1                                     
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           13                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (59)                                   
      Hyperkeratosis                                                                          1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                 1 (2%)       4 (7%)       1 (2%)                                             
      Clear Cell Focus                                 1 (2%)       1 (2%)                    1 (2%)                                
      Cyst                                                          1 (2%)                    1 (2%)                                
      Eosinophilic Focus                                            7 (12%)     10 (17%)     38 (63%)                               
      Eosinophilic Focus, Multiple                                                            1 (2%)                                
      Fatty Change, Diffuse                            1 (2%)       1 (2%)                                                          
      Fatty Change, Focal                                                        1 (2%)       1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation                                                        4 (7%)                                
      Mixed Cell Focus                                 3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
      Necrosis                                         1 (2%)       6 (10%)      5 (8%)      10 (17%)                               
      Thrombosis                                                    1 (2%)                                                          
   Mesentery                                          (3)          (17)         (20)         (10)                                   
      Fat, Necrosis                                    2 (67%)      1 (6%)                                                          
   Pancreas                                           (59)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)                                                                       
      Acinus, Hyperplasia                                                        1 (2%)       2 (3%)                                
      Duct, Ectasia                                                              1 (2%)                                             
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Hyperkeratosis                                   5 (8%)      25 (42%)     23 (38%)     38 (63%)                               
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Hyperplasia, Squamous                           11 (18%)     25 (42%)     23 (38%)     36 (60%)                               
      Necrosis                                                      1 (2%)       2 (3%)                                             
      Ulcer                                            2 (3%)                                 1 (2%)                                
   Stomach, Glandular                                 (59)         (60)         (59)         (59)                                   
      Hyperplasia                                      1 (2%)       4 (7%)       2 (3%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Acute                                                                     1 (2%)                                
   Tongue                                                          (1)          (3)          (1)                                    
      Acanthosis                                                                 1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                   1 (2%)                                                                       
      Mineralization                                                1 (2%)       2 (3%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (57)         (59)         (59)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
   Adrenal Gland, Cortex                              (60)         (57)         (58)         (59)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (59)         (54)         (56)         (59)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (58)         (56)         (54)         (58)                                   
      Pars Distalis, Angiectasis                       1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                      12 (21%)      7 (13%)      2 (4%)       1 (2%)                                
      Pars Intermedia, Hyperplasia                                                            1 (2%)                                
   Thyroid Gland                                      (59)         (58)         (58)         (59)                                   
      Follicular Cell, Hyperplasia                     8 (14%)      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (3)          (5)          (6)          (8)                                    
      Dilatation                                       2 (67%)      3 (60%)      5 (83%)      7 (88%)                               
   Ovary                                              (59)         (59)         (57)         (58)                                   
      Abscess                                          1 (2%)                    1 (2%)                                             
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                            10 (17%)      9 (15%)      6 (11%)      9 (16%)                               
      Degeneration, Cystic                                          1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                       2 (3%)                    1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
   Uterus                                             (60)         (60)         (60)         (59)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Abscess                                          1 (2%)                                                                       
      Cyst                                                                       3 (5%)                                             
      Dilatation                                       6 (10%)      6 (10%)                   1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Thrombosis                                       1 (2%)                                 1 (2%)                                
      Endometrium, Hyperplasia                        43 (72%)     41 (68%)     44 (73%)     57 (97%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Lumbar, Hematopoietic Cell Proliferation         1 (2%)       1 (2%)                                                          
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (2%)       2 (3%)                    1 (2%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (2%)       2 (3%)                                             
      Pancreatic, Infiltration Cellular, Plasma                                                                                     
          Cell                                                                                1 (2%)                                
      Renal, Inflammation, Granulomatous               1 (2%)                                                                       
   Lymph Node, Mandibular                             (56)         (57)         (57)         (57)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Lymph Node, Mesenteric                             (58)         (55)         (59)         (58)                                   
      Angiectasis                                                   2 (4%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (59)         (60)         (60)         (58)                                   
      Hematopoietic Cell Proliferation                 8 (14%)     36 (60%)     45 (75%)     47 (81%)                               
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Erosion                                                       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Hemorrhage                                       3 (5%)       4 (7%)       2 (3%)                                             
      Infiltration Cellular, Histiocyte                2 (3%)       3 (5%)                    1 (2%)                                
      Inflammation, Acute                                           3 (5%)       6 (10%)                                            
      Leukocytosis                                                  1 (2%)       2 (3%)                                             
      Alveolar Epithelium, Hyperplasia                                           2 (3%)       1 (2%)                                
      Bronchiole, Hyperplasia                                                    3 (5%)      43 (72%)                               
   Nose                                               (60)         (59)         (60)         (60)                                   
      Inflammation, Acute                              1 (2%)       1 (2%)       5 (8%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (7)          (8)          (10)                                   
      Hyperplasia                                                                1 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (60)         (60)                                   
      Nephropathy                                                   1 (2%)       2 (3%)       1 (2%)                                
      Cortex, Mineralization                           1 (2%)       1 (2%)                                                          
      Papilla, Mineralization                                                    1 (2%)                                             
      Renal Tubule, Pigmentation                       2 (3%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                           10            9                                     
  Early Deaths                                                                                                                      
    Dead                                               7            7            4            3                                     
    Moribund                                           3           26           40           44                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           18                                                               
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    60           59           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (55)         (58)         (60)         (58)                                   
      Hyperkeratosis                                                                          2 (3%)                                
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
   Gallbladder                                        (55)         (54)         (57)         (59)                                   
      Dilatation                                                                              1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
   Intestine Large, Cecum                             (59)         (57)         (59)         (59)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Liver                                              (60)         (59)         (60)         (60)                                   
      Basophilic Focus                                              7 (12%)      3 (5%)       5 (8%)                                
      Clear Cell Focus                                              1 (2%)       1 (2%)                                             
      Cyst                                                          1 (2%)                    1 (2%)                                
      Eosinophilic Focus                               2 (3%)       3 (5%)       9 (15%)     34 (57%)                               
      Fatty Change, Diffuse                                         1 (2%)                                                          
      Fatty Change, Focal                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Mixed Cell Focus                                 2 (3%)       2 (3%)                                                          
      Necrosis                                         2 (3%)       3 (5%)      14 (23%)      8 (13%)                               
   Mesentery                                          (4)          (15)         (17)         (16)                                   
      Hemorrhage                                       1 (25%)                                                                      
      Fat, Mineralization                                                        2 (12%)                                            
      Fat, Necrosis                                    1 (25%)      1 (7%)                                                          
   Pancreas                                           (60)         (58)         (59)         (59)                                   
      Acinus, Hyperplasia                                                        2 (3%)       1 (2%)                                
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Hyperkeratosis                                   3 (5%)      35 (59%)     32 (53%)     44 (73%)                               
      Hyperplasia, Basal Cell                                                    2 (3%)       2 (3%)                                
      Hyperplasia, Squamous                            8 (13%)     37 (63%)     32 (53%)     38 (63%)                               
      Inflammation, Acute                              1 (2%)                                                                       
      Ulcer                                            5 (8%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (60)         (58)         (59)         (60)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
   Tongue                                             (2)          (1)          (1)          (3)                                    
      Mineralization                                   1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
      Embolus                                                                                 1 (2%)                                
      Mineralization                                                1 (2%)       2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (57)         (58)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Hypertrophy                                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (58)         (59)         (59)                                   
      Hyperplasia                                                                1 (2%)                                             
   Thyroid Gland                                      (57)         (59)         (60)         (60)                                   
      Follicular Cell, Hyperplasia                     1 (2%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (35)         (44)         (42)         (43)                                   
      Abscess                                                                    1 (2%)                                             
      Dilatation                                      30 (86%)     39 (89%)     35 (83%)     28 (65%)                               
   Prostate                                           (59)         (58)         (60)         (57)                                   
      Hyperplasia                                                                2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Bronchial, Infiltration Cellular, Plasma Cell                              1 (2%)                                             
      Bronchial, Infiltration Cellular, Histiocyte                               1 (2%)                                             
      Iliac, Infiltration Cellular, Plasma Cell                     1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hematopoietic Cell Proliferation                 2 (3%)       2 (3%)       1 (2%)                                
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                   2 (3%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (2%)       2 (3%)                                             
   Lymph Node, Mandibular                             (56)         (55)         (57)         (53)                                   
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Lymph Node, Mesenteric                             (56)         (56)         (58)         (58)                                   
      Angiectasis                                      5 (9%)       9 (16%)      4 (7%)       4 (7%)                                
      Hematopoietic Cell Proliferation                              8 (14%)      8 (14%)      1 (2%)                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Depletion Lymphoid                                                                      1 (2%)                                
      Hematopoietic Cell Proliferation                 4 (7%)      36 (61%)     46 (77%)     44 (73%)                               
      Hemorrhage                                                    1 (2%)                                                          
   Thymus                                             (54)         (47)         (53)         (49)                                   
      Epithelial Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (57)         (60)         (59)                                   
      Erosion                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (58)         (60)         (60)                                   
      Inflammation, Acute                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Edema                                            1 (2%)                    1 (2%)                                             
      Embolus Tumor                                                 1 (2%)                                                          
      Hemorrhage                                       3 (5%)                    1 (2%)       1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (3%)       2 (3%)       2 (3%)       4 (7%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Acute                                           1 (2%)       3 (5%)       2 (3%)                                
      Leukocytosis                                                  3 (5%)       5 (8%)       2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       5 (8%)                    2 (3%)                                
      Bronchiole, Hyperplasia                                       1 (2%)       3 (5%)      31 (52%)                               
   Nose                                               (60)         (59)         (60)         (60)                                   
      Inflammation, Acute                                                        1 (2%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)          (3)                                    
      Cornea, Inflammation, Acute                      1 (50%)                                                                      
      Cornea, Necrosis                                 1 (50%)                                                                      
   Harderian Gland                                    (1)          (3)          (11)         (13)                                   
      Hyperplasia                                                                1 (9%)       1 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Nephropathy                                      4 (7%)       3 (5%)                                                          
      Renal Tubule, Regeneration                       1 (2%)                                                                       
   Urinary Bladder                                    (59)         (58)         (59)         (59)                                   
      Calculus Gross Observation                                                 1 (2%)       2 (3%)                                
      Calculus Micro Observation Only                                            1 (2%)       2 (3%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
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