Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/949

TDMS Study 05111-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       1,2,3-TRICHLOROPROPANE


NTP Experiment-Test: 05111-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: GAVAGE                                                                                                     Time: 08:34:18




       Facility:  TSI Mason Research

       Chemical CAS #:  96-18-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                            9            6                                     
  Early Deaths                                                                                                                      
    Moribund                                           8           34           37           48                                     
    Dead                                               1            3            4            1                                     
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           13                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (59)                                   
      Hyperkeratosis                                                                          1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                 1 (2%)       4 (7%)       1 (2%)                                             
      Clear Cell Focus                                 1 (2%)       1 (2%)                    1 (2%)                                
      Cyst                                                          1 (2%)                    1 (2%)                                
      Eosinophilic Focus                                            7 (12%)     10 (17%)     38 (63%)                               
      Eosinophilic Focus, Multiple                                                            1 (2%)                                
      Fatty Change, Diffuse                            1 (2%)       1 (2%)                                                          
      Fatty Change, Focal                                                        1 (2%)       1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation                                                        4 (7%)                                
      Mixed Cell Focus                                 3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
      Necrosis                                         1 (2%)       6 (10%)      5 (8%)      10 (17%)                               
      Thrombosis                                                    1 (2%)                                                          
   Mesentery                                          (3)          (17)         (20)         (10)                                   
      Fat, Necrosis                                    2 (67%)      1 (6%)                                                          
   Pancreas                                           (59)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)                                                                       
      Acinus, Hyperplasia                                                        1 (2%)       2 (3%)                                
      Duct, Ectasia                                                              1 (2%)                                             
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Hyperkeratosis                                   5 (8%)      25 (42%)     23 (38%)     38 (63%)                               
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Hyperplasia, Squamous                           11 (18%)     25 (42%)     23 (38%)     36 (60%)                               
      Necrosis                                                      1 (2%)       2 (3%)                                             
      Ulcer                                            2 (3%)                                 1 (2%)                                
   Stomach, Glandular                                 (59)         (60)         (59)         (59)                                   
      Hyperplasia                                      1 (2%)       4 (7%)       2 (3%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Acute                                                                     1 (2%)                                
   Tongue                                                          (1)          (3)          (1)                                    
      Acanthosis                                                                 1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                   1 (2%)                                                                       
      Mineralization                                                1 (2%)       2 (3%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (57)         (59)         (59)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
   Adrenal Gland, Cortex                              (60)         (57)         (58)         (59)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (59)         (54)         (56)         (59)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (58)         (56)         (54)         (58)                                   
      Pars Distalis, Angiectasis                       1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                      12 (21%)      7 (13%)      2 (4%)       1 (2%)                                
      Pars Intermedia, Hyperplasia                                                            1 (2%)                                
   Thyroid Gland                                      (59)         (58)         (58)         (59)                                   
      Follicular Cell, Hyperplasia                     8 (14%)      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (3)          (5)          (6)          (8)                                    
      Dilatation                                       2 (67%)      3 (60%)      5 (83%)      7 (88%)                               
   Ovary                                              (59)         (59)         (57)         (58)                                   
      Abscess                                          1 (2%)                    1 (2%)                                             
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                            10 (17%)      9 (15%)      6 (11%)      9 (16%)                               
      Degeneration, Cystic                                          1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                       2 (3%)                    1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
   Uterus                                             (60)         (60)         (60)         (59)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Abscess                                          1 (2%)                                                                       
      Cyst                                                                       3 (5%)                                             
      Dilatation                                       6 (10%)      6 (10%)                   1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Thrombosis                                       1 (2%)                                 1 (2%)                                
      Endometrium, Hyperplasia                        43 (72%)     41 (68%)     44 (73%)     57 (97%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Lumbar, Hematopoietic Cell Proliferation         1 (2%)       1 (2%)                                                          
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (2%)       2 (3%)                    1 (2%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (2%)       2 (3%)                                             
      Pancreatic, Infiltration Cellular, Plasma                                                                                     
          Cell                                                                                1 (2%)                                
      Renal, Inflammation, Granulomatous               1 (2%)                                                                       
   Lymph Node, Mandibular                             (56)         (57)         (57)         (57)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Lymph Node, Mesenteric                             (58)         (55)         (59)         (58)                                   
      Angiectasis                                                   2 (4%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (59)         (60)         (60)         (58)                                   
      Hematopoietic Cell Proliferation                 8 (14%)     36 (60%)     45 (75%)     47 (81%)                               
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Erosion                                                       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Hemorrhage                                       3 (5%)       4 (7%)       2 (3%)                                             
      Infiltration Cellular, Histiocyte                2 (3%)       3 (5%)                    1 (2%)                                
      Inflammation, Acute                                           3 (5%)       6 (10%)                                            
      Leukocytosis                                                  1 (2%)       2 (3%)                                             
      Alveolar Epithelium, Hyperplasia                                           2 (3%)       1 (2%)                                
      Bronchiole, Hyperplasia                                                    3 (5%)      43 (72%)                               
   Nose                                               (60)         (59)         (60)         (60)                                   
      Inflammation, Acute                              1 (2%)       1 (2%)       5 (8%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (7)          (8)          (10)                                   
      Hyperplasia                                                                1 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (60)         (60)                                   
      Nephropathy                                                   1 (2%)       2 (3%)       1 (2%)                                
      Cortex, Mineralization                           1 (2%)       1 (2%)                                                          
      Papilla, Mineralization                                                    1 (2%)                                             
      Renal Tubule, Pigmentation                       2 (3%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                           10            9                                     
  Early Deaths                                                                                                                      
    Dead                                               7            7            4            3                                     
    Moribund                                           3           26           40           44                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           18                                                               
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    60           59           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (55)         (58)         (60)         (58)                                   
      Hyperkeratosis                                                                          2 (3%)                                
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
   Gallbladder                                        (55)         (54)         (57)         (59)                                   
      Dilatation                                                                              1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
   Intestine Large, Cecum                             (59)         (57)         (59)         (59)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Liver                                              (60)         (59)         (60)         (60)                                   
      Basophilic Focus                                              7 (12%)      3 (5%)       5 (8%)                                
      Clear Cell Focus                                              1 (2%)       1 (2%)                                             
      Cyst                                                          1 (2%)                    1 (2%)                                
      Eosinophilic Focus                               2 (3%)       3 (5%)       9 (15%)     34 (57%)                               
      Fatty Change, Diffuse                                         1 (2%)                                                          
      Fatty Change, Focal                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Mixed Cell Focus                                 2 (3%)       2 (3%)                                                          
      Necrosis                                         2 (3%)       3 (5%)      14 (23%)      8 (13%)                               
   Mesentery                                          (4)          (15)         (17)         (16)                                   
      Hemorrhage                                       1 (25%)                                                                      
      Fat, Mineralization                                                        2 (12%)                                            
      Fat, Necrosis                                    1 (25%)      1 (7%)                                                          
   Pancreas                                           (60)         (58)         (59)         (59)                                   
      Acinus, Hyperplasia                                                        2 (3%)       1 (2%)                                
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Hyperkeratosis                                   3 (5%)      35 (59%)     32 (53%)     44 (73%)                               
      Hyperplasia, Basal Cell                                                    2 (3%)       2 (3%)                                
      Hyperplasia, Squamous                            8 (13%)     37 (63%)     32 (53%)     38 (63%)                               
      Inflammation, Acute                              1 (2%)                                                                       
      Ulcer                                            5 (8%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (60)         (58)         (59)         (60)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
   Tongue                                             (2)          (1)          (1)          (3)                                    
      Mineralization                                   1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
      Embolus                                                                                 1 (2%)                                
      Mineralization                                                1 (2%)       2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (57)         (58)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Hypertrophy                                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (58)         (59)         (59)                                   
      Hyperplasia                                                                1 (2%)                                             
   Thyroid Gland                                      (57)         (59)         (60)         (60)                                   
      Follicular Cell, Hyperplasia                     1 (2%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (35)         (44)         (42)         (43)                                   
      Abscess                                                                    1 (2%)                                             
      Dilatation                                      30 (86%)     39 (89%)     35 (83%)     28 (65%)                               
   Prostate                                           (59)         (58)         (60)         (57)                                   
      Hyperplasia                                                                2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Bronchial, Infiltration Cellular, Plasma Cell                              1 (2%)                                             
      Bronchial, Infiltration Cellular, Histiocyte                               1 (2%)                                             
      Iliac, Infiltration Cellular, Plasma Cell                     1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hematopoietic Cell Proliferation                 2 (3%)       2 (3%)       1 (2%)                                
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                   2 (3%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (2%)       2 (3%)                                             
   Lymph Node, Mandibular                             (56)         (55)         (57)         (53)                                   
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Lymph Node, Mesenteric                             (56)         (56)         (58)         (58)                                   
      Angiectasis                                      5 (9%)       9 (16%)      4 (7%)       4 (7%)                                
      Hematopoietic Cell Proliferation                              8 (14%)      8 (14%)      1 (2%)                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Depletion Lymphoid                                                                      1 (2%)                                
      Hematopoietic Cell Proliferation                 4 (7%)      36 (61%)     46 (77%)     44 (73%)                               
      Hemorrhage                                                    1 (2%)                                                          
   Thymus                                             (54)         (47)         (53)         (49)                                   
      Epithelial Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (57)         (60)         (59)                                   
      Erosion                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (58)         (60)         (60)                                   
      Inflammation, Acute                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Edema                                            1 (2%)                    1 (2%)                                             
      Embolus Tumor                                                 1 (2%)                                                          
      Hemorrhage                                       3 (5%)                    1 (2%)       1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (3%)       2 (3%)       2 (3%)       4 (7%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05111-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:18  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Acute                                           1 (2%)       3 (5%)       2 (3%)                                
      Leukocytosis                                                  3 (5%)       5 (8%)       2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       5 (8%)                    2 (3%)                                
      Bronchiole, Hyperplasia                                       1 (2%)       3 (5%)      31 (52%)                               
   Nose                                               (60)         (59)         (60)         (60)                                   
      Inflammation, Acute                                                        1 (2%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)          (3)                                    
      Cornea, Inflammation, Acute                      1 (50%)                                                                      
      Cornea, Necrosis                                 1 (50%)                                                                      
   Harderian Gland                                    (1)          (3)          (11)         (13)                                   
      Hyperplasia                                                                1 (9%)       1 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Nephropathy                                      4 (7%)       3 (5%)                                                          
      Renal Tubule, Regeneration                       1 (2%)                                                                       
   Urinary Bladder                                    (59)         (58)         (59)         (59)                                   
      Calculus Gross Observation                                                 1 (2%)       2 (3%)                                
      Calculus Micro Observation Only                                            1 (2%)       2 (3%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 57131-57131/57131


--multipart-boundary--