National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/953

TDMS Study 05111-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       1,2,3-TRICHLOROPROPANE


NTP Experiment-Test: 05111-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: GAVAGE                                                                                                     Time: 08:34:20




       Facility:  TSI Mason Research

       Chemical CAS #:  96-18-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                            9            6                                     
  Early Deaths                                                                                                                      
    Moribund                                           8           34           37           48                                     
    Dead                                               1            3            4            1                                     
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           13                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (59)         (56)         (57)         (59)                                   
      Sarcoma, Metastatic, Uterus                                                             1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                  5 (9%)       7 (12%)      1 (2%)                                
   Intestine Large                                    (59)         (60)         (59)         (60)                                   
      Anorectal Junction, Squamous Cell Carcinoma                                1 (2%)       1 (2%)                                
   Intestine Large, Cecum                             (59)         (58)         (56)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                                            1 (2%)                                
   Intestine Small, Duodenum                          (59)         (56)         (57)         (60)                                   
   Intestine Small, Ileum                             (59)         (59)         (59)         (60)                                   
   Intestine Small, Jejunum                           (59)         (57)         (58)         (60)                                   
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                                            1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                         1 (2%)       3 (5%)                    2 (3%)                                
      Hepatocellular Adenoma                           5 (8%)       7 (12%)      4 (7%)      10 (17%)                               
      Hepatocellular Adenoma, Multiple                 2 (3%)       2 (3%)       5 (8%)      26 (43%)                               
      Histiocytic Sarcoma                              2 (3%)       1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Sarcoma, Metastatic, Uterus                                                             1 (2%)                                
      Squamous Cell Carcinoma, Metastatic                           1 (2%)       2 (3%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                 24 (40%)     25 (42%)     14 (23%)                               
   Mesentery                                          (3)          (17)         (20)         (10)                                   
      Sarcoma, Metastatic, Skin                        1 (33%)                                                                      
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (10%)                               
      Sarcoma, Metastatic, Uterus                                                             1 (10%)                               
      Squamous Cell Carcinoma, Metastatic, Stomach                 16 (94%)     19 (95%)      7 (70%)                               
   Pancreas                                           (59)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Sarcoma, Metastatic, Uterus                                                             1 (2%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Carcinoma, Metastatic, Stomach                 17 (28%)     22 (37%)      8 (13%)                               
   Pharynx                                            (1)                       (1)          (5)                                    
      Squamous Cell Carcinoma                                                    1 (100%)     1 (20%)                               
      Palate, Squamous Cell Carcinoma                                                         4 (80%)                               
      Palate, Squamous Cell Papilloma                  1 (100%)                                                                     
   Salivary Glands                                    (59)         (60)         (58)         (59)                                   
   Stomach                                            (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Squamous Cell Carcinoma                                      30 (51%)     29 (48%)     26 (43%)                               
      Squamous Cell Carcinoma, Multiple                            17 (29%)     26 (43%)     25 (42%)                               
      Squamous Cell Papilloma                                      13 (22%)     14 (23%)     13 (22%)                               
      Squamous Cell Papilloma, Multiple                            15 (25%)     13 (22%)     20 (33%)                               
   Stomach, Glandular                                 (59)         (60)         (59)         (59)                                   
   Tongue                                                          (1)          (3)          (1)                                    
      Squamous Cell Papilloma                                                    1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (57)         (58)         (59)                                   
      Adenoma                                                                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       1 (2%)       1 (2%)                                
   Adrenal Gland, Medulla                             (59)         (54)         (56)         (59)                                   
   Islets, Pancreatic                                 (59)         (60)         (59)         (60)                                   
   Pituitary Gland                                    (58)         (56)         (54)         (58)                                   
      Pars Distalis, Adenoma                           4 (7%)       2 (4%)                                                          
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (59)         (58)         (58)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (59)         (57)         (58)                                   
      Adenoma                                                                                 1 (2%)                                
      Cystadenoma                                                                             1 (2%)                                
      Hemangioma                                                    1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  9 (15%)      4 (7%)       3 (5%)                                
      Teratoma Malignant                               1 (2%)                                                                       
   Oviduct                                            (57)         (58)         (59)         (57)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Uterus                                             (60)         (60)         (60)         (59)                                   
      Adenoma                                                                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Polyp Stromal                                                 2 (3%)       2 (3%)       7 (12%)                               
      Sarcoma                                          1 (2%)                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                  2 (3%)       2 (3%)                                             
      Endometrium, Adenocarcinoma                                   4 (7%)       3 (5%)       8 (14%)                               
      Endometrium, Adenoma                                          1 (2%)                    3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (60)         (60)                                   
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach                                       5 (8%)       8 (13%)      4 (7%)                                
      Pancreatic, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach                                       1 (2%)       1 (2%)                                             
      Renal, Squamous Cell Carcinoma, Metastatic,                                                                                   
           Stomach                                                  1 (2%)                                                          
   Lymph Node, Mandibular                             (56)         (57)         (57)         (57)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                                            1 (2%)                                
   Lymph Node, Mesenteric                             (58)         (55)         (59)         (58)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  7 (13%)     16 (27%)      3 (5%)                                
   Spleen                                             (59)         (60)         (60)         (58)                                   
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Uterus                                                             1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                  6 (10%)      6 (10%)      4 (7%)                                
   Thymus                                             (56)         (55)         (57)         (57)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (45)         (59)         (59)                                   
      Adenoacanthoma                                                             1 (2%)       3 (5%)                                
      Adenocarcinoma                                                2 (4%)                    1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Sarcoma                     2 (3%)                                                                       
                                                             Page   4                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (11)         (15)         (5)                                    
      Hemangioma                                                                 1 (7%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                 10 (91%)     15 (100%)     3 (60%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (59)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Adenoacanthoma, Metastatic, Mammary Gland                                  1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma                     3 (5%)       3 (5%)                   10 (17%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                 1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (5%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic                                        2 (3%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                  6 (10%)      9 (15%)      3 (5%)                                
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Intestine Large                                                                     1 (2%)                                
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (7)          (8)          (10)                                   
      Adenoma                                          3 (100%)     6 (86%)      5 (63%)      9 (90%)                               
      Bilateral, Adenoma                                                         2 (25%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Uterus                                                             1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       3 (5%)                                             
   Urinary Bladder                                    (59)         (58)         (60)         (57)                                   
                                                             Page   5                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              2 (3%)       1 (2%)                                                          
      Lymphoma Malignant Histiocytic                   1 (2%)                    2 (3%)                                             
      Lymphoma Malignant Lymphocytic                   2 (3%)       2 (3%)                    2 (3%)                                
      Lymphoma Malignant Mixed                         1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Undifferentiated Cell        11 (18%)      4 (7%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          54          59          60                                       
     Total Primary Neoplasms                           45         115         113         181                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          36          40          53                                       
     Total Benign Neoplasms                            20          52          47         106                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          48          55          58                                       
     Total Malignant Neoplasms                         25          63          66          75                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1          28          36          28                                       
     Total Metastatic Neoplasm                          2         116         147          67                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                           10            9                                     
  Early Deaths                                                                                                                      
    Dead                                               7            7            4            3                                     
    Moribund                                           3           26           40           44                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           18                                                               
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    60           59           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (55)         (54)         (57)         (59)                                   
      Sarcoma, Metastatic, Stomach                                                            1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                               2 (4%)       1 (2%)                                
   Intestine Large, Cecum                             (59)         (57)         (59)         (59)                                   
   Intestine Small, Duodenum                          (57)         (56)         (60)         (57)                                   
   Intestine Small, Ileum                             (58)         (59)         (60)         (59)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                                            1 (2%)                                
      Lymphoid Tissue, Histiocytic Sarcoma                          1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (57)         (56)         (60)         (59)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                                            2 (3%)                                
   Liver                                              (60)         (59)         (60)         (60)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                  3 (5%)                                                                       
      Hepatocellular Carcinoma                         4 (7%)       8 (14%)      6 (10%)      3 (5%)                                
      Hepatocellular Carcinoma, Multiple                            3 (5%)                                                          
      Hepatocellular Adenoma                          10 (17%)     11 (19%)     13 (22%)      6 (10%)                               
      Hepatocellular Adenoma, Multiple                 2 (3%)       7 (12%)      8 (13%)     25 (42%)                               
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Stomach                                                            1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                 13 (22%)     31 (52%)     29 (48%)                               
   Mesentery                                          (4)          (15)         (17)         (16)                                   
      Hemangiosarcoma, Metastatic, Liver               1 (25%)                                                                      
      Histiocytic Sarcoma                                                        1 (6%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (25%)                                                                      
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (6%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                 13 (87%)     14 (82%)     15 (94%)                               
   Pancreas                                           (60)         (58)         (59)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic, Stomach                                                            1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                 12 (21%)     16 (27%)     11 (19%)                               
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
   Stomach                                            (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Sarcoma                                                                                 1 (2%)                                
      Squamous Cell Carcinoma                                      27 (46%)     19 (32%)     36 (60%)                               
      Squamous Cell Carcinoma, Multiple                            14 (24%)     35 (58%)     19 (32%)                               
      Squamous Cell Papilloma                          3 (5%)      17 (29%)     15 (25%)     24 (40%)                               
      Squamous Cell Papilloma, Multiple                            18 (31%)     10 (17%)     11 (18%)                               
   Tongue                                             (2)          (1)          (1)          (3)                                    
      Squamous Cell Papilloma                                                                 2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (57)         (58)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach                  2 (3%)                                                          
   Thyroid Gland                                      (57)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  6 (10%)      5 (8%)       2 (3%)                                
   Prostate                                           (59)         (58)         (60)         (57)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               2 (3%)       2 (4%)                                
                                                             Page   9                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Seminal Vesicle                                    (60)         (59)         (60)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                  6 (10%)      9 (15%)      1 (2%)                                
   Testes                                             (60)         (59)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Axillary, Histiocytic Sarcoma                                              1 (2%)                                             
      Bronchial, Squamous Cell Carcinoma,                                                                                           
          Metastatic, Stomach                                                                 1 (2%)                                
      Iliac, Squamous Cell Carcinoma, Metastatic,                                                                                   
           Stomach                                                  1 (2%)                                                          
      Mediastinal, Histiocytic Sarcoma                              1 (2%)       1 (2%)                                             
      Mediastinal, Sarcoma, Metastatic, Stomach                                               1 (2%)                                
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach                                       8 (14%)      4 (7%)       3 (5%)                                
      Pancreatic, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach                                       1 (2%)                                                          
   Lymph Node, Mandibular                             (56)         (55)         (57)         (53)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (56)         (58)         (58)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  6 (11%)     12 (21%)      5 (9%)                                
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach                                                                 1 (2%)                                
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Hemangioma                                       1 (2%)       1 (2%)                                                          
      Hemangiosarcoma                                  2 (3%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                  3 (5%)       9 (15%)      5 (8%)                                
   Thymus                                             (54)         (47)         (53)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                  3 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (57)         (60)         (59)                                   
      Prepuce, Squamous Cell Papilloma                 1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (59)         (60)         (60)                                   
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)          (13)         (14)         (9)                                    
      Histiocytic Sarcoma                                                        1 (7%)                                             
      Sarcoma                                                                    1 (7%)                                             
      Sarcoma, Metastatic, Stomach                                                            1 (11%)                               
      Squamous Cell Carcinoma, Metastatic, Stomach                 12 (92%)     11 (79%)      7 (78%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (58)         (60)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     6 (10%)     10 (17%)      3 (5%)       6 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       2 (3%)                    3 (5%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    2 (3%)                                             
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   3 (5%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Sarcoma, Metastatic, Stomach                                                            1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                  6 (10%)     12 (20%)      7 (12%)                               
   Nose                                               (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (11)         (13)                                   
      Adenoma                                          1 (100%)     2 (67%)     10 (91%)     11 (85%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                  2 (3%)                                                          
   Urinary Bladder                                    (59)         (58)         (59)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(59)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Undifferentiated Cell         4 (7%)       3 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05111-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 08:34:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          57          59          60                                       
     Total Primary Neoplasms                           45         129         126         149                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          49          46          50                                       
     Total Benign Neoplasms                            27          70          61          89                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          44          56          58                                       
     Total Malignant Neoplasms                         18          59          65          60                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2          23          38          37                                       
     Total Metastatic Neoplasm                          9          99         130         102                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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