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TDMS Study 05111-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/14/94   
EXP: 05111                 1,2,3-TRICHLOROPROPANE              TIME: 08:57:51   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: C60220   
CONT: NO1-ES-45048                                             CAS: 96-18-4     
PATHOLOGIST: K. MURTHY                                                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


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INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/14/94  
EXP: 05111                 1,2,3-TRICHLOROPROPANE              TIME: 08:57:51  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: C60220  
CONT: NO1-ES-45048                                             CAS: 96-18-4    
PATHOLOGIST: K. MURTHY                                                         

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 10     CENSORED DEATHS 8    TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      16    458   458   486   495   533   592   615   655   682                 |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   459   459                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 6 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 33     CENSORED DEATHS 8    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      400   424   451   458   520   520   535   541   541   561                 |
 |      561   571   577   581   583   585   590   620   636   639                 |
 |      639   641   645   652   660   677   678   678   680   688                 |
 |      690   707   710                                                           |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   459   459                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 20 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 44     CENSORED DEATHS 16   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      385   388   410   436   445   445   452   458   458   469                 |
 |      472   473   477   477   477   478   498   498   505   505                 |
 |      514   526   527   535   540   540   542   560   561   561                 |
 |      561   563   576   577   582   582   590   591   592   597                 |
 |      610   611   616   623                                                     |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   459   459   623   623   623   623                 |
 |      623   623   623   623   623   623                                         |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 60 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 47     CENSORED DEATHS 13   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      322   350   366   368   379   388   389   392   393   406                 |
 |      413   417   423   428   429   435   437   437   442   444                 |
 |      445   452   452   455   458   461   465   470   471   471                 |
 |      473   478   488   490   490   497   499   504   507   514                 |
 |      520   532   534   539   541   542   553                                   |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   459   554   554   554   554   554   554                 |
 |      554   554   554                                                           |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |    98.3  98.3  98.3  98.3  98.3  94.6  88.8  86.9  83.0  81.1      |
 |           |                                                                    |
 |           |                                                                    |
 |6 MG/KG    |   100.0 100.0 100.0 100.0  96.6  93.0  83.1  67.3  51.5  35.6      |
 |           |                                                                    |
 |           |                                                                    |
 |20 MG/KG   |   100.0 100.0 100.0 100.0  95.0  71.5  50.8  26.4   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 |60 MG/KG   |   100.0 100.0 100.0  96.7  78.3  45.0  18.8   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       81.1%        35.6%         0.0%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P<0.001      P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       499.0        595.1        520.1        454.4    |
 |NATURAL DEATHS (C)      |       (59.4)       (14.5)       ( 9.6)       ( 8.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       654.5        617.3        531.0        469.6    |
 |(STANDARD ERROR)        |       (17.7)       (13.9)       ( 9.2)       ( 7.8)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 9      CENSORED DEATHS 10   TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      68    480   482   511   631   691   699   699   728                       |
 |  CENSORED DEATHS                                                               |
 |      461   461   461   461   461   461   463   463   463   463                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 6 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 37     CENSORED DEATHS 10   TERMINAL 13        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      160   207   414   448   516   540   557   558   566   571                 |
 |      574   580   582   583   587   600   601   603   607   609                 |
 |      623   624   629   634   643   653   671   676   680   687                 |
 |      687   693   698   705   719   721   728                                   |
 |  CENSORED DEATHS                                                               |
 |      461   461   461   461   461   461   463   463   463   463                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 20 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 41     CENSORED DEATHS 19   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      312   382   441   442   446   454   458   462   465   465                 |
 |      467   469   473   494   494   501   502   502   502   509                 |
 |      511   522   523   532   540   545   551   558   560   565                 |
 |      570   573   573   578   580   582   589   603   608   617                 |
 |      620                                                                       |
 |  CENSORED DEATHS                                                               |
 |      11    461   461   461   461   461   463   463   463   463                 |
 |      620   620   620   620   620   620   620   620   620                       |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 60 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 49     CENSORED DEATHS 11   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      295   341   377   378   379   379   383   383   390   397                 |
 |      405   407   411   419   420   424   427   432   434   439                 |
 |      442   445   445   447   460   466   467   468   469   469                 |
 |      469   473   473   473   480   480   487   487   490   491                 |
 |      494   496   498   501   504   505   506   508   508                       |
 |  CENSORED DEATHS                                                               |
 |      461   461   461   463   463   511   511   511   511   511                 |
 |      511                                                                       |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |    98.3  98.3  98.3  98.3  98.3  94.3  92.3  92.3  90.3  82.3      |
 |           |                                                                    |
 |           |                                                                    |
 |6 MG/KG    |   100.0  98.3  96.7  96.7  95.0  93.3  89.3  64.9  48.7  26.4      |
 |           |                                                                    |
 |           |                                                                    |
 |20 MG/KG   |   100.0 100.0 100.0  98.3  96.6  76.0  49.3  24.6   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 |60 MG/KG   |   100.0 100.0 100.0  96.7  73.3  36.9   0.0   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      6 MG/KG      20 MG/KG     60 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.3%        26.4%         0.0%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P<0.001      P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       554.3        592.8        515.6        445.3    |
 |NATURAL DEATHS (C)      |       (69.3)       (20.1)       (10.3)       ( 7.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       661.0        601.4        514.8        453.3    |
 |(STANDARD ERROR)        |       (17.3)       (16.5)       (12.5)       ( 6.3)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                       1,2,3-TRICHLOROPROPANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        6 MG/KG          = 2
                                                        20 MG/KG         = 3
                                                        60 MG/KG         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1  1                                               4         3  2
      |    1                                               4   4  4  33 23 2    21
      |                                                                  3   3  21   1
      |                                                           4  44      33  2   11    2
   90 +                                                                       3 3     1    2 1        1
      |                                                               44        33           22       1  1
      |                                                                44        33                      1     1
      |                                                                 444       33          2  2             1    1
   80 +                                                                   44       33            22                 1       1
      |                                                                    44                     22
      |                                                                     44
      |                                                                             3  3           22
P  70 +                                                                      44                     2 2
E     |                                                                                33             2   2
R     |                                                                       4 4       33                2 2
C     |                                                                                  3  3               22
E  60 +                                                                         44
N     |                                                                          44         333              22
T     |                                                                           44                          22
      |                                                                                                        2 2 2
S  50 +                                                                                       3 33
U     |                                                                            44
R     |                                                                             44                             22
V     |                                                                                          3 3                22
I  40 +                                                                              44                              2 2
V     |                                                                               44           33                  22
A     |                                                                                44           3 3                 2   2
L     |                                                                                 44
   30 +                                                                                  4 4
      |                                                                                    444        33 3
      |
      |                                                                                      44
   20 +                                                                                       44         33 3
      |                                                                                        44
      |
      |
   10 +
      |
      |
      |
    0 +                                                                                         4           3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 17 obs hidden.

                                                       1,2,3-TRICHLOROPROPANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        6 MG/KG          = 2
                                                        20 MG/KG         = 3
                                                        60 MG/KG         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1          1             2                     4  3
      |            1             2       2             4  3   4    4 3    2  3      1
      |                                                                   2  32     1   1
      |                                                            4 4        2 3       12    2             1
   90 +                                                                         33            2 2           1        1
      |                                                              44          33                                  11
      |                                                               44                        22                    1   1
      |                                                                444                       22                       1 1
   80 +                                                                                           22
      |                                                                  44       33               22
      |                                                                   44       3  3
      |                                                                    44         33
P  70 +                                                                                             2  2
E     |                                                                     444                        22
R     |
C     |                                                                                33
E  60 +                                                                       4  4      3  3            2 22
N     |                                                                          44
T     |                                                                                    33              22
      |                                                                                     3 3             22
S  50 +                                                                                       33             2 2
U     |                                                                           44           33              2  22
R     |                                                                                                            22
V     |                                                                                         33                  22
I  40 +                                                                            44            33
V     |                                                                             44                               22
A     |                                                                                           33                  22
L     |                                                                                                                2 2
   30 +                                                                              44            33 3
      |                                                                                               3 3                22 2
      |                                                                               44
      |                                                                                                 3 3
   20 +                                                                                44
      |
      |
      |                                                                                 44
   10 +
      |
      |
      |
    0 +                                                                                  4                3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.

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