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TDMS Study 05111-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       1,2,3-TRICHLOROPROPANE


NTP Experiment-Test: 05111-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: GAVAGE                                                                                                     Time: 05:10:27




       Facility:  TSI Mason Research

       Chemical CAS #:  96-18-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            8            8                                     
  Early Deaths                                                                                                                      
    Moribund                                          17           17           42           50                                     
    Dead                                               2            2            2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           30            8                                                  
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    60           59           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)         (57)         (60)         (59)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Intestine Small, Jejunum                           (59)         (57)         (60)         (60)                                   
      Adenocarcinoma                                                             1 (2%)       2 (3%)                                
   Liver                                              (60)         (59)         (60)         (60)                                   
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Sarcoma, Metastatic, Pharynx                                                            1 (2%)                                
   Mesentery                                          (2)          (5)          (4)          (1)                                    
      Nephroblastoma, Metastatic, Kidney                                                      1 (100%)                              
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Acinus, Adenoma                                                            2 (3%)                                             
   Pharynx                                            (1)          (3)          (18)         (23)                                   
      Squamous Cell Carcinoma                                                                 1 (4%)                                
      Palate, Squamous Cell Carcinoma                               1 (33%)     10 (56%)     15 (65%)                               
      Palate, Squamous Cell Papilloma                  1 (100%)     2 (67%)      5 (28%)      3 (13%)                               
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (59)         (59)         (60)                                   
      Squamous Cell Carcinoma                                       3 (5%)       6 (10%)      4 (7%)                                
      Squamous Cell Carcinoma, Multiple                                          3 (5%)       2 (3%)                                
      Squamous Cell Papilloma                                      10 (17%)     30 (51%)     19 (32%)                               
      Squamous Cell Papilloma, Multiple                             4 (7%)       7 (12%)      5 (8%)                                
   Stomach, Glandular                                 (60)         (59)         (60)         (59)                                   
   Tongue                                             (10)         (4)          (21)         (35)                                   
      Squamous Cell Carcinoma                                                   13 (62%)      8 (23%)                               
      Squamous Cell Papilloma                                       3 (75%)      5 (24%)     18 (51%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (58)                                   
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (58)         (60)         (57)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (59)         (56)         (59)         (57)                                   
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)                                                          
      Pheochromocytoma Malignant                       2 (3%)                                                                       
      Pheochromocytoma Benign                          5 (8%)       2 (4%)       1 (2%)                                             
   Islets, Pancreatic                                 (60)         (58)         (60)         (60)                                   
      Adenoma                                          2 (3%)       2 (3%)                    1 (2%)                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (60)         (58)         (59)         (59)                                   
      Pars Distalis, Adenoma                          29 (48%)     30 (52%)     12 (20%)      5 (8%)                                
   Thyroid Gland                                      (60)         (57)         (60)         (60)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  4 (7%)       4 (7%)       4 (7%)                                             
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                                                   3 (5%)       2 (3%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (56)         (56)         (58)         (59)                                   
      Adenoma                                          4 (7%)      11 (20%)     11 (19%)     12 (20%)                               
      Carcinoma                                                                  3 (5%)       5 (8%)                                
      Bilateral, Adenoma                               1 (2%)                    3 (5%)                                             
      Bilateral, Carcinoma                                                       1 (2%)       1 (2%)                                
   Ovary                                              (60)         (58)         (60)         (60)                                   
      Nephroblastoma, Metastatic, Kidney                                                      1 (2%)                                
      Thecoma Benign                                                             1 (2%)                                             
      Bilateral, Hemangioma                                                                   1 (2%)                                
   Uterus                                             (60)         (58)         (60)         (60)                                   
      Hemangioma                                                    1 (2%)                                                          
      Polyp Stromal                                    7 (12%)      4 (7%)       6 (10%)      1 (2%)                                
      Sarcoma                                                       1 (2%)       1 (2%)                                             
      Sarcoma Stromal                                  3 (5%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Bilateral, Polyp Stromal                         2 (3%)       1 (2%)       1 (2%)                                             
      Endometrium, Adenoma                                          1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (5)          (4)          (3)                                                 
   Bone Marrow                                        (60)         (58)         (60)         (60)                                   
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Mediastinal, Sarcoma, Metastatic, Pharynx                                               1 (2%)                                
   Lymph Node, Mandibular                             (58)         (57)         (60)         (58)                                   
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)                                                          
      Sarcoma, Metastatic, Pharynx                                                            1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Pharynx                               1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (58)         (59)         (57)                                   
   Spleen                                             (60)         (57)         (60)         (59)                                   
      Sarcoma, Metastatic, Pharynx                                                            1 (2%)                                
   Thymus                                             (56)         (56)         (59)         (57)                                   
      Epithelial Cell, Thymoma Benign                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (55)         (53)         (50)                                   
      Adenocarcinoma                                   1 (2%)       6 (11%)     11 (21%)     20 (40%)                               
      Adenocarcinoma, Multiple                                                   1 (2%)       2 (4%)                                
      Adenoma                                          1 (2%)                    2 (4%)       1 (2%)                                
      Adenoma, Multiple                                                          1 (2%)                                             
      Fibroadenoma                                    13 (23%)     15 (27%)     12 (23%)      1 (2%)                                
      Fibroadenoma, Multiple                           2 (4%)       8 (15%)      8 (15%)                                            
   Skin                                               (60)         (59)         (59)         (59)                                   
      Squamous Cell Carcinoma                          1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)         (60)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
   Peripheral Nerve                                                                          (2)                                    
      Squamous Cell Carcinoma, Metastatic, Pharynx                                            2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (58)         (59)         (60)                                   
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)       1 (2%)       2 (3%)                                
      Alveolar/Bronchiolar Adenoma                     2 (3%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                                          1 (2%)                                             
      Sarcoma, Metastatic, Pharynx                                                            1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (1)          (2)                                    
      Sarcoma                                                                    1 (100%)                                           
   Eye                                                (4)          (5)          (11)         (19)                                   
      Histiocytic Sarcoma                                                                     1 (5%)                                
   Harderian Gland                                    (1)                       (1)          (9)                                    
      Adenoma                                                                                 1 (11%)                               
   Zymbal's Gland                                                  (1)                       (4)                                    
      Carcinoma                                                     1 (100%)                  4 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (57)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic                                                         1 (2%)                                
      Nephroblastoma                                                                          1 (2%)                                
      Renal Tubule, Adenocarcinoma                                                            1 (2%)                                
   Urinary Bladder                                    (59)         (56)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(59)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            13 (22%)     17 (29%)     14 (23%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          56          56                                       
     Total Primary Neoplasms                           96         135         189         138                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          48          51          40                                       
     Total Benign Neoplasms                            74         102         119          70                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          25          46          48                                       
     Total Malignant Neoplasms                         22          33          70          68                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           3           7                                       
     Total Metastatic Neoplasm                                      5           3          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                                         9                                     
  Early Deaths                                                                                                                      
    Moribund                                          13           16           30           43                                     
    Dead                                               2            2            4                                                  
    Accident                                           1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           14                                                  
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    60           60           59           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (58)         (60)                                   
      Adenocarcinoma, Multiple                                                   1 (2%)                                             
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Large, Rectum                            (59)         (60)         (57)         (60)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Duodenum                          (59)         (60)         (58)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Intestine Small, Ileum                             (59)         (60)         (57)         (59)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Intestine Small, Jejunum                           (59)         (60)         (57)         (60)                                   
      Adenocarcinoma                                                             1 (2%)       1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Liver                                              (60)         (60)         (59)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Hepatocellular Carcinoma                                                   1 (2%)       2 (3%)                                
      Hepatocellular Adenoma                           1 (2%)       1 (2%)       3 (5%)       1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       2 (3%)                                             
   Mesentery                                          (5)          (9)          (12)         (5)                                    
      Sarcoma, Metastatic, Skin                        1 (20%)                                                                      
   Pancreas                                           (60)         (60)         (59)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Mixed Tumor Benign                               1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       1 (2%)                                             
      Acinus, Adenocarcinoma                                                     2 (3%)       1 (2%)                                
      Acinus, Adenoma                                  5 (8%)       7 (12%)      6 (10%)      5 (8%)                                
      Acinus, Adenoma, Multiple                                    14 (23%)     31 (53%)     25 (42%)                               
                                                             Page   7                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Pharynx                                            (1)          (5)          (18)         (16)                                   
      Palate, Squamous Cell Carcinoma                  1 (100%)                 11 (61%)      7 (44%)                               
      Palate, Squamous Cell Papilloma                               2 (40%)      1 (6%)       4 (25%)                               
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
      Squamous Cell Carcinoma                                       9 (15%)     18 (31%)     13 (22%)                               
      Squamous Cell Carcinoma, Multiple                                         10 (17%)      1 (2%)                                
      Squamous Cell Papilloma                                      19 (32%)     27 (46%)     32 (53%)                               
      Squamous Cell Papilloma, Multiple                            12 (20%)      9 (15%)     14 (23%)                               
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
   Tongue                                             (14)         (8)          (13)         (47)                                   
      Squamous Cell Carcinoma                                                                19 (40%)                               
      Squamous Cell Papilloma                                       2 (25%)      9 (69%)     18 (38%)                               
      Squamous Cell Papilloma, Multiple                                                       3 (6%)                                
   Tooth                                              (1)                       (1)                                                 
      Adamantinoma Benign                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (59)         (60)                                   
      Carcinoma, Metastatic, Lung                                                1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (58)         (59)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
      Bilateral, Medulla, Osteosarcoma, Metastatic,                                                                                 
           Bone                                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (59)         (60)         (58)         (59)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       2 (3%)                                             
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          8 (14%)      7 (12%)     12 (21%)                                            
      Bilateral, Pheochromocytoma Benign               2 (3%)                    1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Adenoma                                          9 (15%)      4 (7%)       3 (5%)       1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (58)         (58)         (59)         (59)                                   
      Pars Distalis, Adenoma                           9 (16%)     14 (24%)      8 (14%)      2 (3%)                                
      Pars Distalis, Adenoma, Multiple                              1 (2%)                                                          
      Pars Distalis, Fibrous Histiocytoma,                                                                                          
          Metastatic, Kidney                                                     1 (2%)                                             
   Thyroid Gland                                      (60)         (59)         (59)         (59)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      C-Cell, Adenoma                                  4 (7%)      14 (24%)      4 (7%)       6 (10%)                               
      C-Cell, Adenoma, Multiple                                     1 (2%)                                                          
      C-Cell, Carcinoma                                             1 (2%)       2 (3%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       2 (3%)       2 (3%)                                
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (59)         (59)         (60)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Penis                                                                                     (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Preputial Gland                                    (59)         (57)         (59)         (58)                                   
      Adenoma                                          5 (8%)       3 (5%)       6 (10%)      8 (14%)                               
      Carcinoma                                                     2 (4%)       3 (5%)       5 (9%)                                
      Bilateral, Adenoma                                                                      3 (5%)                                
      Bilateral, Carcinoma                                          1 (2%)                    1 (2%)                                
   Prostate                                           (58)         (60)         (59)         (60)                                   
      Adenoma                                                                    2 (3%)                                             
   Seminal Vesicle                                    (59)         (58)         (58)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       1 (2%)                                             
   Testes                                             (60)         (60)         (59)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)                                                          
      Bilateral, Interstitial Cell, Adenoma           43 (72%)     41 (68%)     42 (71%)     42 (70%)                               
      Interstitial Cell, Adenoma                      12 (20%)     13 (22%)     13 (22%)     10 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (3)          (3)                                                 
   Bone Marrow                                        (60)         (60)         (59)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Lymph Node                                         (60)         (60)         (59)         (60)                                   
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                     1 (2%)                                                          
      Mediastinal, Fibrous Histiocytoma,                                                                                            
                                                             Page   9                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
          Metastatic, Kidney                                                     1 (2%)                                             
      Renal, Fibrous Histiocytoma, Metastatic,                                                                                      
           Kidney                                                                1 (2%)                                             
   Lymph Node, Mandibular                             (60)         (60)         (58)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Sarcoma, Metastatic, Ear                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (59)         (57)         (59)                                   
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Hemangioma                                                                              1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                                            2 (3%)                                
   Spleen                                             (60)         (60)         (59)         (60)                                   
      Fibroma                                          2 (3%)                                                                       
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Hemangioma                                                                              1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Thymus                                             (59)         (58)         (51)         (56)                                   
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Epithelial Cell, Thymoma Benign                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (50)         (41)         (46)                                   
      Fibroadenoma                                     2 (4%)       3 (6%)       1 (2%)                                             
      Fibroadenoma, Multiple                                                     1 (2%)                                             
   Skin                                               (60)         (58)         (58)         (59)                                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Keratoacanthoma                                  2 (3%)       2 (3%)       1 (2%)       2 (3%)                                
      Squamous Cell Carcinoma                                                    1 (2%)       1 (2%)                                
      Squamous Cell Papilloma                                       2 (3%)                    5 (8%)                                
      Trichoepithelioma                                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (3%)       5 (9%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (59)         (60)                                   
      Osteosarcoma                                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (2)          (3)          (5)          (3)                                    
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                                        1 (33%)                               
      Fibrous Histiocytoma, Metastatic                                           1 (20%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (33%)      2 (40%)      1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (59)         (60)                                   
      Astrocytoma Malignant                            1 (2%)                                                                       
      Glioma Malignant                                                           1 (2%)                                             
   Peripheral Nerve                                                             (1)                                                 
      Squamous Cell Carcinoma, Metastatic, Pharynx                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (59)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Kidney                                   1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)       1 (2%)                                             
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach                                                    1 (2%)                                             
   Nose                                               (60)         (60)         (59)         (60)                                   
      Squamous Cell Carcinoma                                       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (2)                                                 
      Sarcoma                                                       1 (100%)     2 (100%)                                           
   Zymbal's Gland                                                                            (4)                                    
      Carcinoma                                                                               3 (75%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (60)                                   
      Fibrous Histiocytoma, Metastatic                                           1 (2%)                                             
      Sarcoma, Metastatic                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
      Renal Tubule, Adenoma                                         2 (3%)      10 (17%)     16 (27%)                               
      Renal Tubule, Adenoma, Multiple                                           10 (17%)     10 (17%)                               
      Renal Tubule, Oncocytoma Benign                                            1 (2%)                                             
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (59)         (60)         (57)         (60)                                   
                                                             Page  11                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Melanoma Malignant, Metastatic, Testes           1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(59)        *(60)                                   
      Leukemia Mononuclear                            16 (27%)     11 (18%)      9 (15%)      6 (10%)                               
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
      Mesothelioma Malignant                           3 (5%)       4 (7%)       4 (7%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05111-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            58          58          57          60                                       
     Total Primary Neoplasms                          138         202         287         286                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 57          58          56          57                                       
     Total Benign Neoplasms                           112         168         212         220                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          28          39          47                                       
     Total Malignant Neoplasms                         26          34          75          66                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           7          10           5                                       
     Total Metastatic Neoplasm                         23          20          45          10                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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