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TDMS Study 05111-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/14/94   
EXP: 05111                 1,2,3-TRICHLOROPROPANE              TIME: 05:26:28   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60220B   
CONT: N01-ES-45048                                             CAS: 96-18-4     
PATHOLOGIST: K. MURTHY                       S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/14/94  
EXP: 05111                 1,2,3-TRICHLOROPROPANE              TIME: 05:26:28  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60220B  
CONT: N01-ES-45048                                             CAS: 96-18-4    
PATHOLOGIST: K. MURTHY                       S. EUSTIS                         

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 11   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      340   485   506   589   591   605   614   614   618   628                 |
 |      648   663   663   677   692                                               |
 |  CENSORED DEATHS                                                               |
 |      450   450   450   450   450   452   452   452   452   452                 |
 |      610                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      577   591   600   603   603   621   654   656   663   678                 |
 |      685   685   689   692   692   694   703   710                             |
 |  CENSORED DEATHS                                                               |
 |      450   450   450   450   450   452   452   452   452   452                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 34     CENSORED DEATHS 11   TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      25    404   404   449   472   514   520   524   536   538                 |
 |      540   590   596   612   614   638   641   649   649   655                 |
 |      660   663   668   669   678   684   685   685   686   698                 |
 |      701   709   720   728                                                     |
 |  CENSORED DEATHS                                                               |
 |      225   450   450   450   450   450   450   452   452   452                 |
 |      452                                                                       |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 30 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 43     CENSORED DEATHS 17   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      327   337   361   368   369   369   382   388   395   401                 |
 |      423   424   425   432   432   444   448   452   459   470                 |
 |      470   473   478   479   480   481   484   484   485   487                 |
 |      487   487   493   493   494   495   501   511   512   512                 |
 |      519   520   527                                                           |
 |  CENSORED DEATHS                                                               |
 |      450   450   450   452   452   452   452   452   534   534                 |
 |      534   534   534   534   534   534   534                                   |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0  98.3  98.3  96.3  94.3  88.3  73.9  69.8      |
 |           |                                                                    |
 |           |                                                                    |
 |3 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  90.0  82.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/KG   |    98.3  98.3  98.3  98.3  94.9  91.0  78.3  74.1  55.0  29.6      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/KG   |   100.0 100.0 100.0  95.0  78.3  47.3   0.0   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       69.8%        64.0%        29.6%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.884      P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       595.5        655.3        594.2        452.5    |
 |NATURAL DEATHS (C)      |       (23.5)       (10.4)       (23.2)       ( 8.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       647.3        660.6        595.6        464.6    |
 |(STANDARD ERROR)        |       (14.7)       (13.3)       (18.7)       ( 7.0)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 19     CENSORED DEATHS 10   TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      424   450   474   526   547   550   550   597   601   626                 |
 |      645   647   652   670   683   699   708   714   717                       |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   463   465   465   465   465                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 19     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      434   460   469   510   545   580   589   604   664   670                 |
 |      677   690   695   696   708   713   713   725   729                       |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   465   465   465   465   465                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 44     CENSORED DEATHS 8    TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      255   405   405   424   434   450   451   479   505   510                 |
 |      510   513   520   521   538   538   550   557   561   563                 |
 |      572   581   584   598   604   605   608   608   612   628                 |
 |      634   637   641   642   643   669   676   683   699   701                 |
 |      709   721   725   725                                                     |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   465   465   465                             |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 30 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 52     CENSORED DEATHS 8    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      85    85    184   233   239   251   294   297   307   310                 |
 |      311   325   330   331   331   336   336   336   345   345                 |
 |      345   345   345   352   354   361   367   367   371   371                 |
 |      371   371   381   385   385   397   399   400   402   407                 |
 |      408   412   416   416   422   423   424   434   441   441                 |
 |      451   464                                                                 |
 |  CENSORED DEATHS                                                               |
 |      463   463   465   465   465   465   465   465                             |
 |                                                                                |
 ==================================================================================

                              1,2,3-TRICHLOROPROPANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0 100.0  98.3  94.7  92.6  82.6  74.5  62.4      |
 |           |                                                                    |
 |           |                                                                    |
 |3 MG/KG    |   100.0 100.0 100.0 100.0 100.0  94.6  90.4  84.3  82.2  61.7      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/KG   |   100.0 100.0  98.3  98.3  93.3  86.4  70.7  51.0  33.4  15.7      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/KG   |    96.7  96.7  90.0  56.7  21.7   0.0   0.0   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.4%        61.7%        15.7%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=1.000N     P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       604.2        624.8        572.6        350.8    |
 |NATURAL DEATHS (C)      |       (20.9)       (22.6)       (15.3)       (10.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       648.9        654.1        579.9        365.9    |
 |(STANDARD ERROR)        |       (14.7)       (14.8)       (14.6)       (10.7)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                       1,2,3-TRICHLOROPROPANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        3 MG/KG          = 2
                                                        10 MG/KG         = 3
                                                        30 MG/KG         = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1   3                                               4 1                                    2
      |     3                                               4 1  4      3            1  1          2  2
      |                                                          44     3       3       1             122
      |                                                                         3  3
   90 +                                                           4  4             3     3 3          1 1 2
      |                                                              444                                112    2
      |                                                                44                  3 3           11    2 2
      |                                                                 4  4                              11     2 2
   80 +                                                                                      33            1  1    22
      |                                                                    44                 3       3       1  1
      |                                                                     4 4                       33 3       1 122
      |                                                                       4 4                                  1 1
P  70 +                                                                         44                       3   3       12     1
E     |                                                                          4 4                                  22
R     |                                                                                                      33        22   2
C     |                                                                            44                         33
E  60 +                                                                                                        3 3
N     |
T     |                                                                                                          33
      |                                                                             44
S  50 +                                                                                                           33
U     |                                                                                                            33
R     |
V     |
I  40 +                                                                              44                             3 3
V     |                                                                                                               33
A     |                                                                                                                333
L     |                                                                               44                                 33
   30 +                                                                                444                                3 3
      |
      |                                                                                  4 4
      |
   20 +                                                                                    44
      |                                                                                     44
      |
      |
   10 +
      |
      |
      |
    0 +                                                                                      4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.

                                                       1,2,3-TRICHLOROPROPANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        3 MG/KG          = 2
                                                        10 MG/KG         = 3
                                                        30 MG/KG         = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1             4                          3                         12
      |               4               4          3                      3  12   1221
      |                               4      4                          3  3      21    2   1
      |                                      4 44                          33   3       2   1 21
   90 +                                         4     4                                       2    2
      |                                               444                       3   3   3      1   2  212
      |                                                 4 4                                             2        2
      |                                                   4 4                                          1   1     22
   80 +                                                     44                          33                 1  1   22
      |                                                                                  3 3                  11   2 2
      |                                                                                    3 3                 1  1  22
      |                                                                                                           1 1 2 2
P  70 +                                                      4 4                             3 3                    1 1
E     |                                                                                        333                    1 1
R     |                                                                                                                 112
C     |                                                        44                                33                      12 21
E  60 +                                                                                           333
N     |                                                         444                                 3  3
T     |                                                                                                33
      |
S  50 +
U     |                                                           4  4                                  33
R     |                                                                                                  3 3
V     |                                                              4 4                                   33
I  40 +                                                                                                     33
V     |                                                                44
A     |                                                                 44
L     |                                                                                                      3    33
   30 +                                                                  44                                        33
      |                                                                   44                                        3 3
      |                                                                                                               33
      |                                                                    44                                          333
   20 +                                                                     44                                           33
      |                                                                      4  4
      |                                                                         4 4                                       3  3
      |
   10 +
      |
      |
      |
    0 +                                                                           4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 18 obs hidden.

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